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Molecular Therapy - Nucleic Acids最新文献

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Secondary follicles enable efficient germline mitochondrial DNA base editing at hard-to-edit site 次级卵泡可在难以编辑的部位进行高效的种系线粒体 DNA 碱基编辑
Molecular Therapy - Nucleic Acids
Pub Date : 2024-03-01 DOI: 10.1016/j.omtn.2024.102170
Qin Xie, Haibo Wu, Hui Long, Caiwen Xiao, Jiaxin Qiu, Weina Yu, Xueyi Jiang, Junbo Liu, Shuo Zhang, Q. Lyu, Lun Suo, Yanping Kuang
{"title":"Secondary follicles enable efficient germline mitochondrial DNA base editing at hard-to-edit site","authors":"Qin Xie, Haibo Wu, Hui Long, Caiwen Xiao, Jiaxin Qiu, Weina Yu, Xueyi Jiang, Junbo Liu, Shuo Zhang, Q. Lyu, Lun Suo, Yanping Kuang","doi":"10.1016/j.omtn.2024.102170","DOIUrl":"https://doi.org/10.1016/j.omtn.2024.102170","url":null,"abstract":"","PeriodicalId":503104,"journal":{"name":"Molecular Therapy - Nucleic Acids","volume":"354 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140279705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Anti-miR-141-3p maintains homeostasis between autophagy and apoptosis by targeting Yy1 in the fetal lumbosacral defecation center of rats 抗miR-141-3p通过靶向大鼠胎儿腰骶部排便中枢的Yy1维持自噬和凋亡之间的平衡
Molecular Therapy - Nucleic Acids
Pub Date : 2024-03-01 DOI: 10.1016/j.omtn.2024.102163
Yue Li, Peiqi Liu, Yifan Yao, Weilin Wang, Huimin Jia, Yuzuo Bai, Zhengwei Yuan, Zhonghua Yang
{"title":"Anti-miR-141-3p maintains homeostasis between autophagy and apoptosis by targeting Yy1 in the fetal lumbosacral defecation center of rats","authors":"Yue Li, Peiqi Liu, Yifan Yao, Weilin Wang, Huimin Jia, Yuzuo Bai, Zhengwei Yuan, Zhonghua Yang","doi":"10.1016/j.omtn.2024.102163","DOIUrl":"https://doi.org/10.1016/j.omtn.2024.102163","url":null,"abstract":"","PeriodicalId":503104,"journal":{"name":"Molecular Therapy - Nucleic Acids","volume":"124 12","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140090676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Synthetic mRNA delivered to human cells leads to expression of Cpl-1 bacteriophage-endolysin with activity against Streptococcus pneumoniae 将合成的 mRNA 运送到人体细胞后，可表达具有抗肺炎链球菌活性的 Cpl-1 噬菌体内溶素
Molecular Therapy - Nucleic Acids
Pub Date : 2024-02-01 DOI: 10.1016/j.omtn.2024.102145
Moritz K. Jansson, Dat Tien Nguyen, Stefan Mikkat, Carolin Warnke, Marc Benjamin Janssen, Philipp Warnke, Bernd Kreikemeyer, N. Patenge
{"title":"Synthetic mRNA delivered to human cells leads to expression of Cpl-1 bacteriophage-endolysin with activity against Streptococcus pneumoniae","authors":"Moritz K. Jansson, Dat Tien Nguyen, Stefan Mikkat, Carolin Warnke, Marc Benjamin Janssen, Philipp Warnke, Bernd Kreikemeyer, N. Patenge","doi":"10.1016/j.omtn.2024.102145","DOIUrl":"https://doi.org/10.1016/j.omtn.2024.102145","url":null,"abstract":"","PeriodicalId":503104,"journal":{"name":"Molecular Therapy - Nucleic Acids","volume":"21 10","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139881224","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
MiR-449a ANTAGONIZES EMT THROUGH IL-6-MEDIATED TRANS- SIGNALING IN LARYNGEAL SQUAMOUS CANCER MiR-449a通过IL-6介导的信号转导抑制喉癌中的EMT
Molecular Therapy - Nucleic Acids
Pub Date : 2024-02-01 DOI: 10.1016/j.omtn.2024.102140
A. Cossu, Federica Melisi, Teresa Maria Rosaria Noviello, Lucia Stefania Pasquale, P. Grisolia, Carla Reale, Marco Bocchetti, Michela Falco, Chiara Tammaro, Nunzio Accardo, Francesco Longo, Salvatore Allosso, Massimo Mesolella, Raffaele Addeo, Francesco Perri, A. Ottaiano, Filippo Ricciardiello, Evžen Amler, C. Ambrosino, G. Misso, Michele Ceccarelli, M. Caraglia, M. Scrima
{"title":"MiR-449a ANTAGONIZES EMT THROUGH IL-6-MEDIATED TRANS- SIGNALING IN LARYNGEAL SQUAMOUS CANCER","authors":"A. Cossu, Federica Melisi, Teresa Maria Rosaria Noviello, Lucia Stefania Pasquale, P. Grisolia, Carla Reale, Marco Bocchetti, Michela Falco, Chiara Tammaro, Nunzio Accardo, Francesco Longo, Salvatore Allosso, Massimo Mesolella, Raffaele Addeo, Francesco Perri, A. Ottaiano, Filippo Ricciardiello, Evžen Amler, C. Ambrosino, G. Misso, Michele Ceccarelli, M. Caraglia, M. Scrima","doi":"10.1016/j.omtn.2024.102140","DOIUrl":"https://doi.org/10.1016/j.omtn.2024.102140","url":null,"abstract":"","PeriodicalId":503104,"journal":{"name":"Molecular Therapy - Nucleic Acids","volume":"11 8","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139817390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
STAT6-targeting Antisense Oligonucleotides against Solitary Fibrous Tumor 针对孤立性纤维瘤的 STAT6 靶向反义寡核苷酸
Molecular Therapy - Nucleic Acids
Pub Date : 2024-02-01 DOI: 10.1016/j.omtn.2024.102154
Yi Li, J. L. Mondaza-Hernandez, D. Moura, Alexey S. Revenko, Angelica Tolentino, John T. Nguyen, Nam Tran, Clark A. Meyer, J. Merino-Garcia, Rafael Ramos, Davide Di Lernia, J. Martín-Broto, Heather N. Hayenga, L. Bleris
{"title":"STAT6-targeting Antisense Oligonucleotides against Solitary Fibrous Tumor","authors":"Yi Li, J. L. Mondaza-Hernandez, D. Moura, Alexey S. Revenko, Angelica Tolentino, John T. Nguyen, Nam Tran, Clark A. Meyer, J. Merino-Garcia, Rafael Ramos, Davide Di Lernia, J. Martín-Broto, Heather N. Hayenga, L. Bleris","doi":"10.1016/j.omtn.2024.102154","DOIUrl":"https://doi.org/10.1016/j.omtn.2024.102154","url":null,"abstract":"","PeriodicalId":503104,"journal":{"name":"Molecular Therapy - Nucleic Acids","volume":"55 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139819997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Unique quinoline orientations shape the molecular recognition of modified aptamer to sclerostin to facilitate enhancing its binding affinity and bone anabolic potential 独特的喹啉取向形成了修饰过的适配体对硬骨蛋白的分子识别，有助于增强其结合亲和力和骨同化潜力
Molecular Therapy - Nucleic Acids
Pub Date : 2024-02-01 DOI: 10.1016/j.omtn.2024.102146
Amu Gubu, Yuan Ma, Sifan Yu, Huarui Zhang, Zefeng Chen, Shuaijian Ni, Razack Abdullah, Huan Xiao, Yihao Zhang, Hong Dai, Hang Luo, Yuanyuan Yu, Luyao Wang, Hewen Jiang, Ning Zhang, Yuan Tian, Haitian Li, Aiping Lu, Baoting Zhang, Ge Zhang
{"title":"Unique quinoline orientations shape the molecular recognition of modified aptamer to sclerostin to facilitate enhancing its binding affinity and bone anabolic potential","authors":"Amu Gubu, Yuan Ma, Sifan Yu, Huarui Zhang, Zefeng Chen, Shuaijian Ni, Razack Abdullah, Huan Xiao, Yihao Zhang, Hong Dai, Hang Luo, Yuanyuan Yu, Luyao Wang, Hewen Jiang, Ning Zhang, Yuan Tian, Haitian Li, Aiping Lu, Baoting Zhang, Ge Zhang","doi":"10.1016/j.omtn.2024.102146","DOIUrl":"https://doi.org/10.1016/j.omtn.2024.102146","url":null,"abstract":"","PeriodicalId":503104,"journal":{"name":"Molecular Therapy - Nucleic Acids","volume":"11 3-4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139892975","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Unique quinoline orientations shape the molecular recognition of modified aptamer to sclerostin to facilitate enhancing its binding affinity and bone anabolic potential 独特的喹啉取向形成了修饰过的适配体对硬骨蛋白的分子识别，有助于增强其结合亲和力和骨同化潜力
Molecular Therapy - Nucleic Acids
Pub Date : 2024-02-01 DOI: 10.1016/j.omtn.2024.102146
Amu Gubu, Yuan Ma, Sifan Yu, Huarui Zhang, Zefeng Chen, Shuaijian Ni, Razack Abdullah, Huan Xiao, Yihao Zhang, Hong Dai, Hang Luo, Yuanyuan Yu, Luyao Wang, Hewen Jiang, Ning Zhang, Yuan Tian, Haitian Li, Aiping Lu, Baoting Zhang, Ge Zhang
{"title":"Unique quinoline orientations shape the molecular recognition of modified aptamer to sclerostin to facilitate enhancing its binding affinity and bone anabolic potential","authors":"Amu Gubu, Yuan Ma, Sifan Yu, Huarui Zhang, Zefeng Chen, Shuaijian Ni, Razack Abdullah, Huan Xiao, Yihao Zhang, Hong Dai, Hang Luo, Yuanyuan Yu, Luyao Wang, Hewen Jiang, Ning Zhang, Yuan Tian, Haitian Li, Aiping Lu, Baoting Zhang, Ge Zhang","doi":"10.1016/j.omtn.2024.102146","DOIUrl":"https://doi.org/10.1016/j.omtn.2024.102146","url":null,"abstract":"","PeriodicalId":503104,"journal":{"name":"Molecular Therapy - Nucleic Acids","volume":"15 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139833185","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Therapeutic role of miR-19a/19b protection from influenza virus infection in patients with coronary heart disease miR-19a/19b 保护冠心病患者免受流感病毒感染的治疗作用
Molecular Therapy - Nucleic Acids
Pub Date : 2024-02-01 DOI: 10.1016/j.omtn.2024.102149
Yanan Xing, Lin Chen, Bin Hu, Yi Li, Huan Mai, Gaojian Li, Shuyi Han, Ye Wang, Yanyi Huang, Ying Tian, Wei Zhang, Yan Gao, Hongxuan He
{"title":"Therapeutic role of miR-19a/19b protection from influenza virus infection in patients with coronary heart disease","authors":"Yanan Xing, Lin Chen, Bin Hu, Yi Li, Huan Mai, Gaojian Li, Shuyi Han, Ye Wang, Yanyi Huang, Ying Tian, Wei Zhang, Yan Gao, Hongxuan He","doi":"10.1016/j.omtn.2024.102149","DOIUrl":"https://doi.org/10.1016/j.omtn.2024.102149","url":null,"abstract":"","PeriodicalId":503104,"journal":{"name":"Molecular Therapy - Nucleic Acids","volume":"5 12","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139818148","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Therapeutic role of miR-19a/19b protection from influenza virus infection in patients with coronary heart disease miR-19a/19b 保护冠心病患者免受流感病毒感染的治疗作用
Molecular Therapy - Nucleic Acids
Pub Date : 2024-02-01 DOI: 10.1016/j.omtn.2024.102149
Yanan Xing, Lin Chen, Bin Hu, Yi Li, Huan Mai, Gaojian Li, Shuyi Han, Ye Wang, Yanyi Huang, Ying Tian, Wei Zhang, Yan Gao, Hongxuan He
{"title":"Therapeutic role of miR-19a/19b protection from influenza virus infection in patients with coronary heart disease","authors":"Yanan Xing, Lin Chen, Bin Hu, Yi Li, Huan Mai, Gaojian Li, Shuyi Han, Ye Wang, Yanyi Huang, Ying Tian, Wei Zhang, Yan Gao, Hongxuan He","doi":"10.1016/j.omtn.2024.102149","DOIUrl":"https://doi.org/10.1016/j.omtn.2024.102149","url":null,"abstract":"","PeriodicalId":503104,"journal":{"name":"Molecular Therapy - Nucleic Acids","volume":"18 1-3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139877931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
STAT6-targeting Antisense Oligonucleotides against Solitary Fibrous Tumor 针对孤立性纤维瘤的 STAT6 靶向反义寡核苷酸
Molecular Therapy - Nucleic Acids
Pub Date : 2024-02-01 DOI: 10.1016/j.omtn.2024.102154
Yi Li, J. L. Mondaza-Hernandez, D. Moura, Alexey S. Revenko, Angelica Tolentino, John T. Nguyen, Nam Tran, Clark A. Meyer, J. Merino-Garcia, Rafael Ramos, Davide Di Lernia, J. Martín-Broto, Heather N. Hayenga, L. Bleris
{"title":"STAT6-targeting Antisense Oligonucleotides against Solitary Fibrous Tumor","authors":"Yi Li, J. L. Mondaza-Hernandez, D. Moura, Alexey S. Revenko, Angelica Tolentino, John T. Nguyen, Nam Tran, Clark A. Meyer, J. Merino-Garcia, Rafael Ramos, Davide Di Lernia, J. Martín-Broto, Heather N. Hayenga, L. Bleris","doi":"10.1016/j.omtn.2024.102154","DOIUrl":"https://doi.org/10.1016/j.omtn.2024.102154","url":null,"abstract":"","PeriodicalId":503104,"journal":{"name":"Molecular Therapy - Nucleic Acids","volume":"17 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139879766","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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