Current methods for evaluating lung function require substantial patient cooperation and rigorous quality control. In contrast, impulse oscillometry (IOS) is a promising alternative that can measure lung mechanics with minimal patient effort and operational ease. IOS applies pressure oscillations to the airways and analyzes the resulting signals. However, previous studies on IOS have been limited to frequency-domain features derived from its response signals, while neglecting valuable time-domain information. To bridge this gap, we developed a deep learning model that fuses time- and frequency-domain IOS data for lung function evaluation. An internal dataset (2,702 cases) and an external dataset (335 cases) were retrospectively collected for model training and validation. Model performance was first evaluated through ablation studies and then tested across different demographic subgroups. Finally, Grad-CAM was employed to improve model interpretability. Results showed that our model accurately predicted lung function parameters, including FEV1/FVC (mean absolute errors [MAEs] of 3.78 and 4.33 %), FEV1 (MAEs of 0.235 and 0.270 L), and FVC (MAEs of 0.264 and 0.315 L), in internal and external validation sets. The model also demonstrated strong performance in respiratory disease prescreening, achieving AUCs of 0.989 and 0.980 with sensitivities of 73.97 % and 71.47 % for detecting airway obstruction, and AUCs of 0.938 and 0.925 with sensitivities of 76.41 % and 66.24 % for classifying four ventilation patterns across the two sets. By fusing time- and frequency-domain IOS data, this study offers a new strategy for pulmonary function evaluation, facilitating more efficient prescreening for pulmonary diseases.
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