Accurate brain tumor segmentation from magnetic resonance imaging (MRI) remains a significant challenge due to early loss of spatial detail, inadequate contextual representation, and ineffective decoder fusion. In this paper, we propose EPSO-Net, a multi-objective evolutionary neural architecture search (NAS) framework that integrates three specialized modules: UTSA for preserving spatial encoding and enhancing low-level feature representation, Astra for capturing semantic abstraction and multi-scale context, and Revo for improving decoder refinement through attention-guided fusion of feature maps. These modules work synergistically within a flexible modular 3D search space, enabling dynamic architecture optimization during the evolutionary process. EPSO-Net utilizes a particle swarm optimization (PSO)-guided mutation fusion mechanism that enables efficient exploration of the search space, adjusting mutation behavior based on performance feedback. To the best of our knowledge, this is the first multi-objective evolutionary NAS framework employing PSO-guided mutation fusion to adapt mutation strategies, driving the search towards optimal solutions in a resource-efficient manner. Experiments on the BraTS 2021, BraTS 2020, and MSD Brain Tumor datasets demonstrate that EPSO-Net outperforms nine state-of-the-art methods, achieving high dice similarity coefficients (DSC) of 93.89%, 95.02%, and 91.25%, low Hausdorff distance (HD95) of 1.14 mm, 1.02 mm, and 1.44 mm, and strong Grad-CAM IoU (GIoU) of 89.32%, 90.12%, and 85.68%, respectively. EPSO-Net also demonstrates reliable generalization to the CHAOS, PROMISE12, and ACDC datasets. Furthermore, it significantly reduces model complexity, lowers FLOPS, accelerates inference, and enhances interpretability. The full code will be publicly available at: https://github.com/Farhana005/EPSO-Net.
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