With Alzheimer’s disease affecting approximately 50 million people globally, early detection has emerged as a critical public health priority in aging societies. This paper proposes a novel multi-level information fusion framework for handwriting-based Alzheimer’s disease detection, addressing the fundamental challenges of data scarcity and high-dimensional feature representation. Our approach integrates: (1) structural fusion through tensor representation preserving the multi-dimensional nature of handwriting data, (2) feature-level fusion via Tucker decomposition achieving 80% parameter reduction while maintaining discriminative information, (3) knowledge fusion through our proposed transferable source domain detection algorithm that selectively integrates relevant knowledge from related domains, and (4) decision-level fusion with a two-stage transfer-debias mechanism that mitigates negative transfer risks. Experiments on the DARWIN dataset demonstrate that our transfer learning approach achieves 93.33% accuracy and 99.10% sensitivity, substantially outperforming existing handwriting-based AD detection methods (best reported: 88.29% accuracy, 90.28% sensitivity). The framework exhibits exceptional robustness in small sample scenarios, maintaining 87.50% accuracy with just 10% of the training data. Our comprehensive analysis reveals kinematic features with an importance score of 35.3%, while temporal features collectively contribute 25.7%—among which total time (9.4%) emerges as a key marker within the temporal category. The proposed framework presents a promising non-invasive approach for early Alzheimer’s detection in aging populations, with the potential to facilitate earlier intervention and substantial healthcare cost reductions.
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