Pub Date : 2024-07-26DOI: 10.58806/ijhmr.2024.v3i07n10
Dr. Zeenath Begum, Dr. Zoya Riyaz Syeda, Dr. Rohit Anil Khare, Dr. Sumaiyya Firdous, Dr. Asra Fatima
The thyroid disorders are diagnosed through ultrasonography and USG guided fine-needle aspiration cytology (FNAC) worldwide with implementation of the Bethesda system of reporting Thyroid cytology as an excellent less invasive primary line of investigation.1 The thyroid is an important and prime endocrine organ. The swelling of the thyroid gland is the commonest manifestation of various disorders affecting the thyroid, including non-neoplastic lesions and neoplastic both benign and malignant disorders.2 Bethesda categorization in FNAC aids in the decision for the management along with thyroid profile and radiological imaging. The Bethesda system of reporting thyroid cytology after FNAC is a uniform reporting system of thyroid cytology. FNAC is cheap, cost-effective, less invasive and less time-consuming.3,4 The thyroid gland composed histologically of 20-40 thyroid follicles, they produce triiodothyronine(T3) and thyroxin (T4) which are in turn regulated by thyroid-stimulating hormone (TSH) which is produced by the anterior pituitary gland. Thyroid lesions can be categorized as euthyroid, hypothyroid or hyperthyroid based on T3, T4, and TSH levels.5 The current goal in thyroid nodule evaluation is to determine whether it is benign or malignant. High resolution ultrasonography (USG) is the first line of investigation in evaluation of thyroid nodules. Thyroid imaging reporting and data system (TIRADS) is an USG-based risk stratification system for classification of thyroid nodules. Subjects with high-risk category of TIRADS undergo USG-guided fine needle aspiration cytology. Conventional FNAC usually yields fewer results compared to USG-guided FNAC.1 Data regarding sonographic classification of thyroid nodule and its cytological association with respect to biochemical findings and final histopathological diagnosis is less studied in the Indian population. Hence, justifying the correlation of various thyroid lesions involving FNAC, biochemical markers, and imaging by USG
{"title":"Cytomorphological Correlational Study of Thyroid Disorders with Imaging and Biochemical Serum Markers","authors":"Dr. Zeenath Begum, Dr. Zoya Riyaz Syeda, Dr. Rohit Anil Khare, Dr. Sumaiyya Firdous, Dr. Asra Fatima","doi":"10.58806/ijhmr.2024.v3i07n10","DOIUrl":"https://doi.org/10.58806/ijhmr.2024.v3i07n10","url":null,"abstract":"The thyroid disorders are diagnosed through ultrasonography and USG guided fine-needle aspiration cytology (FNAC) worldwide with implementation of the Bethesda system of reporting Thyroid cytology as an excellent less invasive primary line of investigation.1 The thyroid is an important and prime endocrine organ. The swelling of the thyroid gland is the commonest manifestation of various disorders affecting the thyroid, including non-neoplastic lesions and neoplastic both benign and malignant disorders.2 Bethesda categorization in FNAC aids in the decision for the management along with thyroid profile and radiological imaging. The Bethesda system of reporting thyroid cytology after FNAC is a uniform reporting system of thyroid cytology. FNAC is cheap, cost-effective, less invasive and less time-consuming.3,4 The thyroid gland composed histologically of 20-40 thyroid follicles, they produce triiodothyronine(T3) and thyroxin (T4) which are in turn regulated by thyroid-stimulating hormone (TSH) which is produced by the anterior pituitary gland. Thyroid lesions can be categorized as euthyroid, hypothyroid or hyperthyroid based on T3, T4, and TSH levels.5 The current goal in thyroid nodule evaluation is to determine whether it is benign or malignant. High resolution ultrasonography (USG) is the first line of investigation in evaluation of thyroid nodules. Thyroid imaging reporting and data system (TIRADS) is an USG-based risk stratification system for classification of thyroid nodules. Subjects with high-risk category of TIRADS undergo USG-guided fine needle aspiration cytology. Conventional FNAC usually yields fewer results compared to USG-guided FNAC.1 Data regarding sonographic classification of thyroid nodule and its cytological association with respect to biochemical findings and final histopathological diagnosis is less studied in the Indian population. Hence, justifying the correlation of various thyroid lesions involving FNAC, biochemical markers, and imaging by USG","PeriodicalId":504355,"journal":{"name":"International Journal Of Health & Medical Research","volume":"53 13","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141799971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-26DOI: 10.58806/ijhmr.2024.v3i07n16
Alexis López Alonso, Hector Gabriel Zamora Valenzuela
Background: currently obesity and overweight are two of the major public health problems worldwide, which haunts the health of more and more young people around the world, as this problem advances so does medicine, treatments and surgical procedures, such is the case of bariatric surgeries, which can have a great positive impact on the lives of patients who undergo these procedures, however, there are also post-surgical complications, such as acute cholestatic syndromes, which are becoming more and more frequent, so finding and describing a treatment to avoid these complications could be a fundamental piece in the management of these patients. Methods: We conducted a purely observational and descriptive study by collecting data and information through a national and international literature review, where we selected control cases and meta-analysis which are detailed and described during this review. Results: During the last years the popularity of the use of ursodeoxycholic acid has grown, since it has been mentioned its use out of indications as a prophylactic treatment after bariatric surgery, this alternative may sound favorable for the treating physician and for the patient, since it is safe and avoids complications according to different studies. Conclusions: Multiple studies, including all those reviewed during this research show a highly positive benefit of the use of ursodeoxycholic acid, it is noteworthy that during this research, the only study that does not mention a positive effect of the use of ursodeoxycholic acid is the study of Muriel Coupaye et al. which mentions that no difference was found between the groups treated and not treated with ursodeoxycholic acid with 500mg/day.
{"title":"The Role of Ursodeoxycholic Acid After Bariatric Surgery","authors":"Alexis López Alonso, Hector Gabriel Zamora Valenzuela","doi":"10.58806/ijhmr.2024.v3i07n16","DOIUrl":"https://doi.org/10.58806/ijhmr.2024.v3i07n16","url":null,"abstract":"Background: currently obesity and overweight are two of the major public health problems worldwide, which haunts the health of more and more young people around the world, as this problem advances so does medicine, treatments and surgical procedures, such is the case of bariatric surgeries, which can have a great positive impact on the lives of patients who undergo these procedures, however, there are also post-surgical complications, such as acute cholestatic syndromes, which are becoming more and more frequent, so finding and describing a treatment to avoid these complications could be a fundamental piece in the management of these patients. Methods: We conducted a purely observational and descriptive study by collecting data and information through a national and international literature review, where we selected control cases and meta-analysis which are detailed and described during this review. Results: During the last years the popularity of the use of ursodeoxycholic acid has grown, since it has been mentioned its use out of indications as a prophylactic treatment after bariatric surgery, this alternative may sound favorable for the treating physician and for the patient, since it is safe and avoids complications according to different studies. Conclusions: Multiple studies, including all those reviewed during this research show a highly positive benefit of the use of ursodeoxycholic acid, it is noteworthy that during this research, the only study that does not mention a positive effect of the use of ursodeoxycholic acid is the study of Muriel Coupaye et al. which mentions that no difference was found between the groups treated and not treated with ursodeoxycholic acid with 500mg/day.","PeriodicalId":504355,"journal":{"name":"International Journal Of Health & Medical Research","volume":"32 17","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141800809","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Breast cancer and periodontitis, potentially related conditions affects millions worldwide . Latest research reveals that both the diseases share common pathways and these play a critical role in the development , progression and treatment of both conditions . Periodontitis , a chronic progressive inflammatory disease of the periodontium is being highlighted for its incrimination in causing various systemic diseases . The aim of this article is to put light onto all probable pathways that makes periodontal inflammation a risk factor for Breast cancer .. This article draws attention to the commonalities shared by the two diseases, in the context of chronic inflammation , microbial dysbiosis and immunological pathways in the initiation and progression of breast cancer . It emphasizes the role of multifaceted research to reveal the underlying pathways seen in this association . The inflammatory microenvironment seen in periodontitis mimics the microenvironment that brings about the process of oncogenesis in breast cancer . Crucial bacterial species intertwined in periodontitis, like Fusobacterium nucleatum and Porphyromonas gingivalis, are seen within breast cancer tissues, indicating a possible etiological link through bacteremia and later metastatic colonization . The inflammatory terrain specific of periodontitis, rich in cytokines, prostaglandins, and interleukins, simulates the inflammatory environment that promotes oncogenesis in breast tissue . Inheritable tendencies and hormonal influences, particularly estrogen metabolism intermediated by oral and gut microbiota, further intertwine these conditions . Elevated C- reactive protein situations, a marker of systemic inflammation seen in periodontitis, are also associated with increased breast cancer threat . Research indicates that elevated levels of molecules like RANK and its ligand RANKL may promote progression and metastasis in breast cancer . A comprehension of these pathways that link Periodontitis to breast cancer can offer beneficial awareness for developing preventive and curative strategies, if proven . Such knowledge could lead to innovative interventions targeting inflammatory processes potentially mitigating the risk and progress of the two diseases . After going through various available literature it could be said that periodontal pathogens might influence breast cancer either directly or through systemic inflammatory pathways . While some evidence hints at a possible link between periodontitis and breast cancer . Databases including PubMed , PubMed Central and ResearchGate were searched for articles yielding 32 relevant English articles between 2016 to 2023, which had one of the keywords of “Periodontal Disease” , “Breast cancer” , “Inflammation” and “Myeloid derived Suppressor cells” in their titles . A total of 13 English articles were selected by the researcher for final analysis.
{"title":"Periodontal Pathogens and Breast Cancer: Unravelling the Biological Links","authors":"Aashiya yadav, C.S. Baiju, Kalyani Agarwal, Snigdha Singh","doi":"10.58806/ijhmr.2024.v3i07n15","DOIUrl":"https://doi.org/10.58806/ijhmr.2024.v3i07n15","url":null,"abstract":"Breast cancer and periodontitis, potentially related conditions affects millions worldwide . Latest research reveals that both the diseases share common pathways and these play a critical role in the development , progression and treatment of both conditions . Periodontitis , a chronic progressive inflammatory disease of the periodontium is being highlighted for its incrimination in causing various systemic diseases . The aim of this article is to put light onto all probable pathways that makes periodontal inflammation a risk factor for Breast cancer .. This article draws attention to the commonalities shared by the two diseases, in the context of chronic inflammation , microbial dysbiosis and immunological pathways in the initiation and progression of breast cancer . It emphasizes the role of multifaceted research to reveal the underlying pathways seen in this association . The inflammatory microenvironment seen in periodontitis mimics the microenvironment that brings about the process of oncogenesis in breast cancer . Crucial bacterial species intertwined in periodontitis, like Fusobacterium nucleatum and Porphyromonas gingivalis, are seen within breast cancer tissues, indicating a possible etiological link through bacteremia and later metastatic colonization . The inflammatory terrain specific of periodontitis, rich in cytokines, prostaglandins, and interleukins, simulates the inflammatory environment that promotes oncogenesis in breast tissue . Inheritable tendencies and hormonal influences, particularly estrogen metabolism intermediated by oral and gut microbiota, further intertwine these conditions . Elevated C- reactive protein situations, a marker of systemic inflammation seen in periodontitis, are also associated with increased breast cancer threat . Research indicates that elevated levels of molecules like RANK and its ligand RANKL may promote progression and metastasis in breast cancer . A comprehension of these pathways that link Periodontitis to breast cancer can offer beneficial awareness for developing preventive and curative strategies, if proven . Such knowledge could lead to innovative interventions targeting inflammatory processes potentially mitigating the risk and progress of the two diseases . After going through various available literature it could be said that periodontal pathogens might influence breast cancer either directly or through systemic inflammatory pathways . While some evidence hints at a possible link between periodontitis and breast cancer . Databases including PubMed , PubMed Central and ResearchGate were searched for articles yielding 32 relevant English articles between 2016 to 2023, which had one of the keywords of “Periodontal Disease” , “Breast cancer” , “Inflammation” and “Myeloid derived Suppressor cells” in their titles . A total of 13 English articles were selected by the researcher for final analysis.","PeriodicalId":504355,"journal":{"name":"International Journal Of Health & Medical Research","volume":"20 15","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141801068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-22DOI: 10.58806/ijhmr.2024.v3i07n08
lbtihaj H. Ali, Huda Oudah Saheb, Laith S. Alhiti R, Ali A. Al- Fahham
Spectroscopic techniques can be classified based on the types of ray, reaction between the material and the energy, the form of material used and the usages for which the assay is utilized. Several types of spectroscopies have been developed, but the most frequently-used spectrometer utilized for biochemical analyses include nuclear magnetic resonance (NMR), Raman spectroscopy, infrared spectroscopy, ultraviolet and visible spectroscopy, and atomic spectroscopy. This review highlights the main types of spectroscopies and their principle of action and other technical issue. Spectroscopic chemical analysis now plays a vital role in pharmaceutical manufacturing. It is used for medication identification and quality assessment, as well as detecting metal elements and compounds present in solid or water materials — not forgetting its significant value in medical diagnostics
{"title":"Spectroscopy: Types, Principles And Clinical Uses","authors":"lbtihaj H. Ali, Huda Oudah Saheb, Laith S. Alhiti R, Ali A. Al- Fahham","doi":"10.58806/ijhmr.2024.v3i07n08","DOIUrl":"https://doi.org/10.58806/ijhmr.2024.v3i07n08","url":null,"abstract":"Spectroscopic techniques can be classified based on the types of ray, reaction between the material and the energy, the form of material used and the usages for which the assay is utilized. Several types of spectroscopies have been developed, but the most frequently-used spectrometer utilized for biochemical analyses include nuclear magnetic resonance (NMR), Raman spectroscopy, infrared spectroscopy, ultraviolet and visible spectroscopy, and atomic spectroscopy. This review highlights the main types of spectroscopies and their principle of action and other technical issue. Spectroscopic chemical analysis now plays a vital role in pharmaceutical manufacturing. It is used for medication identification and quality assessment, as well as detecting metal elements and compounds present in solid or water materials — not forgetting its significant value in medical diagnostics","PeriodicalId":504355,"journal":{"name":"International Journal Of Health & Medical Research","volume":"43 9","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141815209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-22DOI: 10.58806/ijhmr.2024.v3i07n07
Ahmed M. Amshawee, Maryam A. Hussain, Seenaa Taqi Mansour Al Muhtaser, Ali A. Al- Faham
The deoxyribonucleic acid (DNA) carries hereditary codes which is translated by the cells to synthesize the ribonucleic acid (RNA) and polypeptides which can generate and perform vital function. The double helix structure is the most studied model of the DNA that was proposed by Watson and Crick. The capability of DNA to work as a genetic material can be stored and conducted during cell division to permit this information to be doubled and transmitted to the incoming generation. Any damage in the structure of DNA is an essential direct cause for the progression of cancer and other disorders. The factors for DNA damage can be classified as exogenous and endogenous factors. In this review article, we highlight the evidence-supported information about the structure, functions and clinical significance of DNA.
脱氧核糖核酸（DNA）携带遗传密码，细胞将其翻译成核糖核酸（RNA）和多肽，从而产生并执行重要功能。双螺旋结构是研究最多的 DNA 模型，由沃森和克里克提出。DNA 作为遗传物质的能力可以在细胞分裂过程中储存和传导，以便将信息加倍并传递给下一代。DNA 结构的任何损伤都是导致癌症和其他疾病恶化的重要直接原因。造成 DNA 损伤的因素可分为外源性因素和内源性因素。在这篇综述文章中，我们将重点介绍有关 DNA 结构、功能和临床意义的证据支持信息。
{"title":"Structure, Functions And Clinical Significance Of DNA: A Review Article","authors":"Ahmed M. Amshawee, Maryam A. Hussain, Seenaa Taqi Mansour Al Muhtaser, Ali A. Al- Faham","doi":"10.58806/ijhmr.2024.v3i07n07","DOIUrl":"https://doi.org/10.58806/ijhmr.2024.v3i07n07","url":null,"abstract":"The deoxyribonucleic acid (DNA) carries hereditary codes which is translated by the cells to synthesize the ribonucleic acid (RNA) and polypeptides which can generate and perform vital function. The double helix structure is the most studied model of the DNA that was proposed by Watson and Crick. The capability of DNA to work as a genetic material can be stored and conducted during cell division to permit this information to be doubled and transmitted to the incoming generation. Any damage in the structure of DNA is an essential direct cause for the progression of cancer and other disorders. The factors for DNA damage can be classified as exogenous and endogenous factors. In this review article, we highlight the evidence-supported information about the structure, functions and clinical significance of DNA.","PeriodicalId":504355,"journal":{"name":"International Journal Of Health & Medical Research","volume":"6 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141817428","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-22DOI: 10.58806/ijhmr.2024.v3i07n06
Manar G. Alhussine, Hanan A. Mohammed, Yas A. Khudhair Al-Ameri, Ali A. Al-fahham
This research aimed to establish whether the Aspergillus species identified from bronchitis patients were mycotoxigenic or non-mycotoxigenic fungi in sputum and serum samples. A total sample of 170 subjects with ages ranging from 15 to 72 years— were obtained from Al-Najaf Province (Al-Sadr Medical City) between December 2023 and April 2024, divided into patient (n=176) and healthy groups (n=34). The Aspergillus genera isolated were cultured on coconut agar medium and screened under UV light (360 nm); each sputum and serum sample was also tested using the ELISA technique. All Aspergillus strains exhibited blue fluorescence on Coconut Cream Agar (CCA) media under UV light, confirming positivity. The study identified production of aflatoxins B1 and ochratoxins-A in sputum and serum samples among both patients with bronchitis and control groups. The results showed a significant difference in patient groups by samples (P≤ 0.05) while the healthy groups showed a non-significant (P>0.05) difference. Most Aspergillus spp. Isolated from bronchitis patients were found to produce aflatoxin B1 and ochratoxin-A on coconut agar medium— mycotoxins extracts included sputum (about 68.4% for aflatoxins-B1 and 41.7% for serum samples) and sputum (about 77.6% for ochratoxin-A and 91.7% for serum samples) taken from bronchitis patients, which were identified using ELISA technique.
{"title":"Evaluation Of Some Aspergillus Mycotoxins In Patients With Bronchitis In Al-Najaf City","authors":"Manar G. Alhussine, Hanan A. Mohammed, Yas A. Khudhair Al-Ameri, Ali A. Al-fahham","doi":"10.58806/ijhmr.2024.v3i07n06","DOIUrl":"https://doi.org/10.58806/ijhmr.2024.v3i07n06","url":null,"abstract":"This research aimed to establish whether the Aspergillus species identified from bronchitis patients were mycotoxigenic or non-mycotoxigenic fungi in sputum and serum samples. A total sample of 170 subjects with ages ranging from 15 to 72 years— were obtained from Al-Najaf Province (Al-Sadr Medical City) between December 2023 and April 2024, divided into patient (n=176) and healthy groups (n=34). The Aspergillus genera isolated were cultured on coconut agar medium and screened under UV light (360 nm); each sputum and serum sample was also tested using the ELISA technique. All Aspergillus strains exhibited blue fluorescence on Coconut Cream Agar (CCA) media under UV light, confirming positivity. The study identified production of aflatoxins B1 and ochratoxins-A in sputum and serum samples among both patients with bronchitis and control groups. The results showed a significant difference in patient groups by samples (P≤ 0.05) while the healthy groups showed a non-significant (P>0.05) difference. Most Aspergillus spp. Isolated from bronchitis patients were found to produce aflatoxin B1 and ochratoxin-A on coconut agar medium— mycotoxins extracts included sputum (about 68.4% for aflatoxins-B1 and 41.7% for serum samples) and sputum (about 77.6% for ochratoxin-A and 91.7% for serum samples) taken from bronchitis patients, which were identified using ELISA technique.","PeriodicalId":504355,"journal":{"name":"International Journal Of Health & Medical Research","volume":"28 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141815634","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-19DOI: 10.58806/ijhmr.2024.v3i07n05
Chika Rani Safitri, Yosua Adi Setiawan, A. Krismariono
Gingival recession is a term when the marginal gingiva apically shifts from its normal position to the root surface level beyond the cementoenamel junction. Gingival recession can cause aesthetic and functional problems. Coronally advanced flap combined with Platelet-Rich Fibrin (PRF) is considered a better therapy for the autogenous gingival graft because it doesn’t require a second surgical site. PRF is a potential growth factor for periodontal regeneration. The existence of leukocytes and various cytokines contained in PRF enables the self-modulation of infectious and inflammatory processes. This case report aims to describe the use of PRF for root coverage on the labial surfaces of the mandibular anterior teeth. Case Presentation: A female 42 years old, systemically healthy, non‑smoking patient came with a chief complaint that the mandibular teeth often feel sensitive when exposed to iced or something cold. Clinical examinations revealed Miller’s Class I in #42 and #43. Case Management: The patient said that she doesn’t want a second surgical site. After initial therapy and maintenance, the patient was treated with a coronally advanced flap combined with PRF. Conclusion: The growth factors in PRF are involved in wound healing and is proposed as tissue regeneration promoter. PRF with coronally advanced flap has been shown to be a promising and successful approach for root coverage procedures. It significantly presents a significant gain in clinical attachment and also simultaneously helps with the gingival recession.
{"title":"PRF As An Alternative Membrane To Autogenous Gingival Graft In The Treatment For Gingival Recession","authors":"Chika Rani Safitri, Yosua Adi Setiawan, A. Krismariono","doi":"10.58806/ijhmr.2024.v3i07n05","DOIUrl":"https://doi.org/10.58806/ijhmr.2024.v3i07n05","url":null,"abstract":"Gingival recession is a term when the marginal gingiva apically shifts from its normal position to the root surface level beyond the cementoenamel junction. Gingival recession can cause aesthetic and functional problems. Coronally advanced flap combined with Platelet-Rich Fibrin (PRF) is considered a better therapy for the autogenous gingival graft because it doesn’t require a second surgical site. PRF is a potential growth factor for periodontal regeneration. The existence of leukocytes and various cytokines contained in PRF enables the self-modulation of infectious and inflammatory processes. This case report aims to describe the use of PRF for root coverage on the labial surfaces of the mandibular anterior teeth. Case Presentation: A female 42 years old, systemically healthy, non‑smoking patient came with a chief complaint that the mandibular teeth often feel sensitive when exposed to iced or something cold. Clinical examinations revealed Miller’s Class I in #42 and #43. Case Management: The patient said that she doesn’t want a second surgical site. After initial therapy and maintenance, the patient was treated with a coronally advanced flap combined with PRF. Conclusion: The growth factors in PRF are involved in wound healing and is proposed as tissue regeneration promoter. PRF with coronally advanced flap has been shown to be a promising and successful approach for root coverage procedures. It significantly presents a significant gain in clinical attachment and also simultaneously helps with the gingival recession.","PeriodicalId":504355,"journal":{"name":"International Journal Of Health & Medical Research","volume":"124 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141821631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-17DOI: 10.58806/ijhmr.2024.v3i07n03
Filka Georgieva, Zhenya Stoyanova
Psoriatic arthritis (PA) is a chronic autoimmune inflammatory disease characterized by persistent joint inflammation and severe erythemo-squamous plaques on the skin. In recent decades, biological agents such as IL-17 drugs have been applied in the treatment of PA with very good results. The treatment has its adverse effects, but severe pancytopenia is extremely rare. We report a case of а patient who was treated with secukinumab for 3 years and in the background of this treatment unlocked urticaria vasculitis and severe pancytopenia. In relation to psoriatic arthritis, there is almost complete clearing of the skin, but the joint pains are remitting in nature.
银屑病关节炎（PA）是一种慢性自身免疫性炎症疾病，以持续性关节炎症和严重的皮肤红斑鳞屑为特征。近几十年来，IL-17 等生物制剂被用于治疗银屑病，并取得了很好的疗效。治疗有其不良反应，但严重的全血细胞减少症极为罕见。我们报告了一例使用 secukinumab 治疗 3 年的 а 患者，在治疗过程中出现了荨麻疹性血管炎和严重的全血细胞减少。在银屑病关节炎方面，皮肤几乎完全消退，但关节疼痛却在缓解。
{"title":"Severe Pancytopenia And Urticaria Vasculitis Induced By Secukinumab In Psoriatic Arthritis: A Case Report","authors":"Filka Georgieva, Zhenya Stoyanova","doi":"10.58806/ijhmr.2024.v3i07n03","DOIUrl":"https://doi.org/10.58806/ijhmr.2024.v3i07n03","url":null,"abstract":"Psoriatic arthritis (PA) is a chronic autoimmune inflammatory disease characterized by persistent joint inflammation and severe erythemo-squamous plaques on the skin. In recent decades, biological agents such as IL-17 drugs have been applied in the treatment of PA with very good results. The treatment has its adverse effects, but severe pancytopenia is extremely rare. We report a case of а patient who was treated with secukinumab for 3 years and in the background of this treatment unlocked urticaria vasculitis and severe pancytopenia. In relation to psoriatic arthritis, there is almost complete clearing of the skin, but the joint pains are remitting in nature.","PeriodicalId":504355,"journal":{"name":"International Journal Of Health & Medical Research","volume":" 14","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141827795","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-17DOI: 10.58806/ijhmr.2024.v3i07n02
Mohammed Hasan Barrak, Farah Ali Dawood, Safa Nihad Abed Shubar, Ali A. Al-fahham
Lactate dehydrogenase (LDH) is a family of enzymes that catalyzes oxidation-reduction enzymes, the interconversion between pyruvic acid and lactic acid. It is an enzyme that terminates the final catabolic reaction in which glucose id hydrolyzes anaerobically (glycolysis) resulting in lactate from pyruvate. These varied biochemical characteristics significantly influence its specificity to cells, tissues, and organs. Although LDH is mainly found in the cytoplasm, it is also located in multiple organelles. The presence of blood LDH implies an enzyme marker, and it may be a sign of death for many conditions such as ARDS, severe COVID-19, and some cancers. When LDH levels in the blood are increased they can reflect liver disease or anemia plus heart attack in addition to bone fracture — and muscle trauma. This also includes cancerous formations; infections like encephalitis or meningitis — along with HIV.
{"title":"Pathophysiology, The Biochemical And Clinical Significance Of Lactate Dehydrogenase","authors":"Mohammed Hasan Barrak, Farah Ali Dawood, Safa Nihad Abed Shubar, Ali A. Al-fahham","doi":"10.58806/ijhmr.2024.v3i07n02","DOIUrl":"https://doi.org/10.58806/ijhmr.2024.v3i07n02","url":null,"abstract":"Lactate dehydrogenase (LDH) is a family of enzymes that catalyzes oxidation-reduction enzymes, the interconversion between pyruvic acid and lactic acid. It is an enzyme that terminates the final catabolic reaction in which glucose id hydrolyzes anaerobically (glycolysis) resulting in lactate from pyruvate. These varied biochemical characteristics significantly influence its specificity to cells, tissues, and organs. Although LDH is mainly found in the cytoplasm, it is also located in multiple organelles. The presence of blood LDH implies an enzyme marker, and it may be a sign of death for many conditions such as ARDS, severe COVID-19, and some cancers. When LDH levels in the blood are increased they can reflect liver disease or anemia plus heart attack in addition to bone fracture — and muscle trauma. This also includes cancerous formations; infections like encephalitis or meningitis — along with HIV.","PeriodicalId":504355,"journal":{"name":"International Journal Of Health & Medical Research","volume":" 7","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141829185","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-17DOI: 10.58806/ijhmr.2024.v3i07n04
Hayder Neamah Hassan, Maryam Falih Hasan, Ali Hussein Abbas, Ali A. Al-fahham
Congenital malformation of the heart stands as one of the most common congenital anomalies at birth. However, with the advancement in cardiovascular medicine and surgery, a majority of the children can nowadays still live for about 20 years. Unfortunately, the prolonged survival has its own consequences and many children face late complications among which heart failure and arrhythmias are predominant. The burden of congenital heart pathology looms large on the pediatric population mortality and morbidity statistics. While a number of endovascular procedures have been conceived as a substitute for surgical correction, percutaneous interventions have shown positive outcomes in many cases — all this without the stress and trauma associated with surgery especially for frail children. Our aim was to provide a review to look into possibility and effectiveness of endovascular procedures plus Internal prosthetics for managing pediatric patients with congenital malformation of the heart.
{"title":"Surgical Interventions In Children With Congenital Heart Disease: A Review Article","authors":"Hayder Neamah Hassan, Maryam Falih Hasan, Ali Hussein Abbas, Ali A. Al-fahham","doi":"10.58806/ijhmr.2024.v3i07n04","DOIUrl":"https://doi.org/10.58806/ijhmr.2024.v3i07n04","url":null,"abstract":"Congenital malformation of the heart stands as one of the most common congenital anomalies at birth. However, with the advancement in cardiovascular medicine and surgery, a majority of the children can nowadays still live for about 20 years. Unfortunately, the prolonged survival has its own consequences and many children face late complications among which heart failure and arrhythmias are predominant. The burden of congenital heart pathology looms large on the pediatric population mortality and morbidity statistics. While a number of endovascular procedures have been conceived as a substitute for surgical correction, percutaneous interventions have shown positive outcomes in many cases — all this without the stress and trauma associated with surgery especially for frail children. Our aim was to provide a review to look into possibility and effectiveness of endovascular procedures plus Internal prosthetics for managing pediatric patients with congenital malformation of the heart.","PeriodicalId":504355,"journal":{"name":"International Journal Of Health & Medical Research","volume":" 12","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141831024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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