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Altered immune response to exercise in patients with chronic fatigue syndrome/myalgic encephalomyelitis: a systematic literature review. 慢性疲劳综合征/肌痛性脑脊髓炎患者运动后免疫反应改变:系统文献综述
IF 7.3 4区 医学 Q1 Medicine Pub Date : 2014-01-01
Jo Nijs, Andrea Nees, Lorna Paul, Margot De Kooning, Kelly Ickmans, Mira Meeus, Jessica Van Oosterwijck

An increasing number of studies have examined how the immune system of patients with Chronic Fatigue Syndrome (CFS), or myalgic encephalomyelitis, responds to exercise. The objective of the present study was to systematically review the scientific literature addressing exercise-induced immunological changes in CFS patients compared to healthy control subjects. A systematic literature search was conducted in the PubMed and Web of science databases using different keyword combinations. We included 23 case control studies that examined whether CFS patients, compared to healthy sedentary controls, have a different immune response to exercise. The included articles were evaluated on their methodological quality. Compared to the normal response of the immune system to exercise as seen in healthy subjects, patients with CFS have a more pronounced response in the complement system (i.e. C4a split product levels), oxidative stress system (i.e. enhanced oxidative stress combined with a delayed and reduced anti-oxidant response), and an alteration in the immune cells' gene expression profile (increases in post-exercise interleukin-10 and toll-like receptor 4 gene expression), but not in circulating pro- or anti-inflammatory cytokines. Many of these immune changes relate to post-exertional malaise in CFS, a major characteristic of the illness. The literature review provides level B evidence for an altered immune response to exercise in patients with CFS.

越来越多的研究调查了慢性疲劳综合征(CFS)或肌痛性脑脊髓炎患者的免疫系统对运动的反应。本研究的目的是系统地回顾有关运动引起的CFS患者免疫变化的科学文献,并与健康对照者进行比较。使用不同的关键词组合在PubMed和Web of science数据库中进行系统的文献检索。我们纳入了23个病例对照研究,这些研究检查了CFS患者与健康的久坐对照组相比,是否对运动有不同的免疫反应。对纳入的文章进行方法学质量评价。与健康受试者的免疫系统对运动的正常反应相比,CFS患者在补体系统(即C4a分裂产物水平)、氧化应激系统(即氧化应激增强合并抗氧化反应延迟和减少)和免疫细胞基因表达谱的改变(运动后白细胞介素-10和toll样受体4基因表达增加)中有更明显的反应。但在促炎细胞因子或抗炎细胞因子循环中不存在。许多这些免疫变化与慢性疲劳综合症的运动后不适有关,这是该疾病的主要特征。文献综述提供了B级证据,证明CFS患者对运动的免疫反应发生了改变。
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引用次数: 0
Exploring the importance of translational regulation in the inflammatory responses by a genome-wide approach. 通过全基因组方法探索炎症反应中翻译调节的重要性。
IF 7.3 4区 医学 Q1 Medicine Pub Date : 2014-01-01
Hiroaki Sako, Katsuhiko Suzuki

It is widely recognized that exercise has an important role in inflammation regulation. To understand inflammatory mechanisms, extensive studies on the transcriptome and proteome have been conducted. However, interpreting these results is difficult, partly due to technical difficulties that impose some restriction on the accuracy and comprehensiveness of measurements. Here we first mention some limitations of studies involving large scale proteomics and high-throughput transcriptomics and further introduce a newly developed genome-wide translational analysis which may overcome some of the limitations and discover novel cellular dynamics. We then show preliminary results obtained by conducting a genome-wide translational analysis of the early inflammatory response of macrophages in response to lipopolysaccharide (LPS), and discuss the potential to identify novel factors by employing a genome-wide translational analysis.

人们普遍认为运动在炎症调节中起着重要作用。为了了解炎症机制,对转录组和蛋白质组进行了广泛的研究。然而,解释这些结果是困难的,部分原因是由于技术上的困难对测量的准确性和全面性施加了一些限制。在这里,我们首先提到了大规模蛋白质组学和高通量转录组学研究的一些局限性,并进一步介绍了一种新开发的全基因组翻译分析,它可能克服一些局限性并发现新的细胞动力学。然后,我们展示了通过对巨噬细胞对脂多糖(LPS)的早期炎症反应进行全基因组翻译分析获得的初步结果,并讨论了通过全基因组翻译分析确定新因素的可能性。
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引用次数: 0
Exercise-induced leukocyte apoptosis. 运动诱导的白细胞凋亡。
IF 7.3 4区 医学 Q1 Medicine Pub Date : 2014-01-01
Karsten Krüger, Frank C Mooren

Physical exercise is well known to affect leukocyte numbers and function. While regular exercise training has been shown to enhance specific immune functions, acute bouts of intensive exercise often lead to a pro-inflammatory response accompanied by a transient lymphocytopenia and neutrophilia. It can be assumed, that lymphocytopenia can be attributed at least partially to an enhanced lymphocyte apoptosis. In contrast, regulation of neutrophil apoptosis after exercise remains controversial since studies demonstrated both an up-regulation as well as a down-regulation of cell death. However, these discrepancies may be due to differences in exercise protocols, subjects' fitness levels, and to different methodological approaches. Two major signalling pathways of exercise induced apoptosis have been identified. First the external receptor mediated pathway using death receptors, and second the internal, oxidative-mediated pathway which encompasses the mitochondria. Potential apoptosis modulating mediators are reactive oxygen species (ROS), glucocorticoids and cytokines which are part of the systemic inflammatory response evoked after acute intensive exercise. Finally, the physiological impact and clinical relevance of leukocyte apoptosis will be discussed. On the one hand, exercise-induced apoptosis might be a mechanism to remove activated and potentially autoreactive immune cells. On the other hand, apoptosis might be a regulatory mechanism which is necessary for tissue reorganization and adaptational training processes.

众所周知,体育锻炼可以影响白细胞的数量和功能。虽然有规律的运动训练已被证明可以增强特定的免疫功能,但急性剧烈运动往往会导致促炎反应,并伴有短暂的淋巴细胞减少和中性粒细胞增多。可以假设,淋巴细胞减少症可以至少部分归因于淋巴细胞凋亡的增强。相比之下,运动后中性粒细胞凋亡的调节仍然存在争议,因为研究表明细胞死亡既有上调也有下调。然而,这些差异可能是由于不同的运动方案,受试者的健康水平和不同的方法方法。已经确定了运动诱导细胞凋亡的两种主要信号通路。首先是使用死亡受体的外部受体介导途径,其次是包含线粒体的内部氧化介导途径。潜在的细胞凋亡调节介质是活性氧(ROS)、糖皮质激素和细胞因子,它们是急性剧烈运动后引起的全身炎症反应的一部分。最后,将讨论白细胞凋亡的生理影响和临床意义。一方面,运动诱导的细胞凋亡可能是一种清除活化和潜在的自身反应性免疫细胞的机制。另一方面,细胞凋亡可能是组织重组和适应性训练过程所必需的调节机制。
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引用次数: 0
Exercise immunology meets MiRNAs. 运动免疫学与MiRNAs。
IF 7.3 4区 医学 Q1 Medicine Pub Date : 2014-01-01
Julia A Makarova, Diana V Maltseva, Vladimir V Galatenko, Asghar Abbasi, Daniil G Maximenko, Anatoly I Grigoriev, Alexander G Tonevitsky, Hinnak Northoff

A large body of evidence indicates modified expression of protein-coding genes in response to different kinds of physical activity. Recent years have exposed another level of regulation of cellular processes mediated by non-coding RNAs. MicroRNAs (miRNAs) are one of the largest families of non-coding RNAs. MiRNAs mediate post-transcriptional regulation of gene expression. The amount of data supporting the key role of miRNAs in the adaptation of the immune and other body systems to exercise steadily grows. MiRNAs change their expression profiles after exercise and seem to be involved in regulation of exercise-responsive genes in immune and other cell types. Here we discuss existing data and future directions in the field.

大量证据表明,不同类型的身体活动会改变蛋白质编码基因的表达。近年来揭示了非编码rna介导的细胞过程的另一个水平的调节。MicroRNAs (miRNAs)是最大的非编码rna家族之一。MiRNAs介导基因表达的转录后调控。支持mirna在免疫和其他身体系统适应运动中的关键作用的数据量稳步增长。mirna在运动后改变其表达谱,似乎参与了免疫细胞和其他细胞类型中运动反应基因的调节。在这里,我们讨论现有的数据和未来的方向。
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引用次数: 0
Sex differences in upper respiratory symptoms prevalence and oral-respiratory mucosal immunity in endurance athletes. 耐力运动员上呼吸道症状患病率及口腔-呼吸道黏膜免疫的性别差异。
IF 7.3 4区 医学 Q1 Medicine Pub Date : 2014-01-01
Cheng-Shiun He, Nicolette C Bishop, Michal K Handzlik, Ayu S Muhamad, Michael Gleeson

The purpose of this study was to examine sex differences in oral-respiratory mucosal immunity and the incidence, severity and duration of upper respiratory symptoms (URS) episodes in endurance athletes during a 16-week winter training period. Blood was collected from 210 subjects (147 men and 63 women) at the start and end of the study for determination of differential leukocyte counts. Timed collections of unstimulated saliva were obtained at the start and at 4-week intervals during the study period. Saliva samples were analysed for salivary antimicrobial peptides and proteins (AMPs). Weekly training and daily illness logs were kept using validated questionnaires. Training loads averaged 11 h/week of moderate-vigorous physical activity and were not different for males and females. The salivary concentration of lysozyme and lactoferrin (both P < 0.04) but not salivary immunoglobulin A (SIgA) or amylase were higher in males than females. Saliva flow rates were significantly higher in males than females (P < 0.03) and consequently so were the salivary secretion rates of lysozyme, lactoferrin and amylase (all P < 0.01) but not SIgA (P = 0.097). Total blood leukocyte, monocyte and lymphocyte counts were not different between the sexes but females had higher numbers of circulating neutrophils (P = 0.040). The average number of URS episodes was 0.6 +/- 0.8 (mean +/- SD) in males and 0.8 +/- 1.0 in females (P = 0.103) and the number of URS days was higher in females (4.7 vs 6.8 days, P < 0.02). The duration of URS episodes was longer in females (11.6 vs 15.5 days, P < 0.03). The findings of this study concur with recent reports of illness incidence at major competitive games indicating that female athletes may be more susceptible than their male counterparts to URS and that lower oral-respiratory mucosal immunity may, in part, account for this.

本研究的目的是研究在为期16周的冬季训练期间,耐力运动员口腔-呼吸粘膜免疫的性别差异以及上呼吸道症状(URS)发作的发生率、严重程度和持续时间。在研究开始和结束时收集了210名受试者(147名男性和63名女性)的血液,以确定白细胞计数的差异。在研究开始时和研究期间每隔4周采集一次未受刺激的唾液。分析唾液样本中的抗菌肽和抗菌蛋白(AMPs)。每周培训和每日疾病记录使用有效的问卷。训练负荷平均为11小时/周的中等强度体力活动,在男性和女性之间没有差异。男性唾液溶菌酶和乳铁蛋白浓度显著高于女性(P均< 0.04),而唾液免疫球蛋白A (SIgA)和淀粉酶浓度不显著高于女性。雄鼠唾液流量显著高于雌鼠(P < 0.03),溶菌酶、乳铁蛋白和淀粉酶分泌率显著高于雌鼠(P < 0.01), SIgA分泌率不显著(P = 0.097)。血液白细胞总数、单核细胞总数和淋巴细胞总数在两性之间无显著差异,但女性的循环中性粒细胞数量较高(P = 0.040)。男性平均尿路发作次数为0.6 +/- 0.8次(平均+/- SD),女性平均尿路发作次数为0.8 +/- 1.0次(P = 0.103),女性尿路发作天数较高(4.7 vs 6.8天,P < 0.02)。女性尿潴留发作时间更长(11.6天vs 15.5天,P < 0.03)。这项研究的结果与最近关于大型竞技比赛中疾病发病率的报告一致,表明女运动员可能比男运动员更容易患尿路综合征,而较低的口腔呼吸粘膜免疫力可能是部分原因。
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引用次数: 0
The effects of exercise, sex, and menstrual phase on salivary antimicrobial proteins. 运动、性和月经期对唾液抗菌蛋白的影响。
IF 7.3 4区 医学 Q1 Medicine Pub Date : 2014-01-01
Trevor Gillum, Matthew Kuennen, Tara Miller, Layla Riley

Salivary antimicrobial protein (AMP) expression is a primary determinant of mucosal immunity. This expression can be altered by exercise. While salivary IgA has been extensively studied, less is known about Lysozyme (Lys) and Lactoferrin (Lac). Knowledge on how sex and menstrual phase affect mucosal immunity is also limited. The purpose of this study was to examine how sex, menstrual phase, and exercise impact IgA, Lys, and Lac expression. Men (n = 9) and women (n = 9) ran for 45 min at 75% VO2(peak). Women were tested in the follicular and luteal phase. Saliva was collected pre-exercise, immediately post-exercise and 1 h postexercise. Pre-exercise, women had higher secretion rates of IgA compared to men (154 +/- 106 vs 85 +/- 44 microg/min) (p < 0.05). Lac secretion rate increased with exercise in both sexes and remained above baseline 1 h after exercise in men (7460 +/- 4839 ng/min), but had returned to pre-exercise levels at 1 h post-exercise in women (5720 +/- 4661 ng/min) (time * sex interaction, p < 0.05). Men had higher secretion rates of Lys (p < 0.05) at each time point compared to women (Men pre-exercise: 31042 +/- 23132, post-exercise: 29521 +/- 13205, 1 h post-exercise: 41229 +/- 31270 ng/min vs Women pre-exercise: 11585 +/- 10367, post-exercise: 22719 +/- 19452, 1 h post-exercise: 17303 +/- 11419 ng/min). Both sexes increased the secretion rate of Lys and Lac with exercise, whereas IgA was unchanged. Menstrual phase did not affect IgA, Lys, or Lac and men and women did not differ in saliva flow rates. In conclusion, regularly menstruating women who are not taking hormonal contraceptives differently express AMPs compared to men.

唾液抗菌蛋白(AMP)的表达是黏膜免疫的主要决定因素。这种表达可以通过锻炼而改变。虽然唾液IgA已被广泛研究,但对溶菌酶(Lys)和乳铁蛋白(Lac)知之甚少。关于性别和月经期如何影响粘膜免疫的知识也很有限。本研究的目的是研究性别、经期和运动对IgA、Lys和Lac表达的影响。男性(n = 9)和女性(n = 9)以75%的VO2(峰值)跑45分钟。女性在卵泡期和黄体期进行测试。分别在运动前、运动后立即和运动后1小时采集唾液。运动前,女性的IgA分泌率高于男性(154 +/- 106 vs 85 +/- 44 μ g/min) (p < 0.05)。Lac分泌率随运动而增加,男性运动后1小时仍高于基线水平(7460 +/- 4839 ng/min),而女性运动后1小时恢复到运动前水平(5720 +/- 4661 ng/min)(时间*性别交互作用,p < 0.05)。男性在各时间点的赖氨酸分泌率均高于女性(男性运动前:31042 +/- 23132,运动后:29521 +/- 13205,运动后1小时:41229 +/- 31270 ng/min,女性运动前:11585 +/- 10367,运动后:22719 +/- 19452,运动后1小时:17303 +/- 11419 ng/min)。随着运动的进行,两种性别的Lys和Lac的分泌率均有所增加,而IgA的分泌率则保持不变。月经期对IgA、Lys和Lac没有影响,男性和女性的唾液流率也没有差异。总之,不服用激素避孕药的定期来月经的女性与男性表达amp的方式不同。
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引用次数: 0
Alkaloids and athlete immune function: caffeine, theophylline, gingerol, ephedrine, and their congeners. 生物碱与运动员免疫功能:咖啡因、茶碱、姜辣素、麻黄碱及其同系物。
IF 7.3 4区 医学 Q1 Medicine Pub Date : 2014-01-01
David S Senchina, Justus E Hallam, Marian L Kohut, Norah A Nguyen, M Ann d N Perera

Plant alkaloids are found in foods, beverages, and supplements consumed by athletes for daily nutrition, performance enhancement, and immune function improvement. This paper examined possible immunomodulatory roles of alkaloids in exercise contexts, with a focus on human studies. Four representative groups were scrutinized: (a) caffeine (guaranine, mateine); (b) theophylline and its isomers, theobromine and paraxanthine; (c) ginger alkaloids including gingerols and shogaol; and (d) ephedra alkaloids such as ephedrine and pseudoephedrine. Emerging or prospective alkaloid sources (Goji berry, Noni berry, and bloodroot) were also considered. Human in vitro and in vivo studies on alkaloids and immune function were often conflicting. Caffeine may be immunomodulatory in vivo depending on subject characteristics, exercise characteristics, and immune parameters measured. Caffeine may exhibit antioxidant capacities. Ginger may exert in vivo anti-inflammatory effects in certain populations, but it is unclear whether these effects are due to alkaloids or other biochemicals. Evidence for an immunomodulatory role of alkaloids in energy drinks, cocoa, or ephedra products in vivo is weak to nonexistent. For alkaloid sources derived from plants, variability in the reviewed studies may be due to the presence of unrecognized alkaloids or non-alkaloid compounds (which may themselves be immunomodulatory), and pre-experimental factors such as agricultural or manufacturing differences. Athletes should not look to alkaloids or alkaloid-rich sources as a means of improving immune function given their inconsistent activities, safety concerns, and lack of commercial regulation.

植物生物碱存在于食品、饮料和运动员日常营养、提高表现和改善免疫功能的补品中。本文研究了生物碱在运动环境中可能的免疫调节作用,重点是人体研究。四组有代表性的组被仔细审查:(a)咖啡因(瓜拉宁,马泰因);(b)茶碱及其异构体,可可碱和副黄嘌呤;(c)姜生物碱,包括姜辣素和姜酚;(四)麻黄碱、伪麻黄碱等麻黄生物碱。新兴或潜在的生物碱来源(枸杞、诺丽莓和血根)也被考虑在内。生物碱与人体免疫功能的体外和体内研究常常相互矛盾。咖啡因在体内可能具有免疫调节作用,这取决于受试者的特征、运动特征和测量的免疫参数。咖啡因可能具有抗氧化能力。生姜可能在某些人群中发挥体内抗炎作用,但尚不清楚这些作用是由于生物碱还是其他生物化学物质。生物碱在能量饮料、可可或麻黄制品中的免疫调节作用在体内的证据很弱,甚至不存在。对于来自植物的生物碱来源,所审查的研究中的差异可能是由于存在未被识别的生物碱或非生物碱化合物(它们本身可能具有免疫调节作用),以及农业或生产差异等实验前因素。运动员不应该指望生物碱或富含生物碱的来源作为提高免疫功能的手段,因为它们的活动不一致,安全问题,缺乏商业监管。
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引用次数: 0
Spinal cord injury: known and possible influences on the immune response to exercise. 脊髓损伤:已知和可能对运动免疫反应的影响。
IF 7.3 4区 医学 Q1 Medicine Pub Date : 2013-01-01
C A Leicht, V L Goosey-Tolfrey, N C Bishop

A spinal cord injury (SCI) can increase the risk of infection by impacting on many aspects of immune function; one particularly well-documented observation is a reduction in lymphocyte numbers. The vast majority of lymphoid cells express adrenergic receptors. Therefore, autonomic function loss and concomitant alterations in resting and post-exercise catecholamine concentrations, particularly so in individuals with a tetraplegia, may impact directly on immune cells and depress immunity. Other factors are further likely to contribute, examples including altered muscular, endocrine and cardiovascular function following SCI. However, some alterations, such as increases in natural killer cell cytotoxicity following exercise in those with a tetraplegia, are unrelated to the catecholamine response. Likewise, mucosal immunity in individuals with a tetraplegia appears to be similarly influenced by exercise as in the able-bodied population. Indeed, rehabilitation therapy and exercise can increase some measures of immunity and autonomic function in those with an SCI. It is therefore possible that compensatory mechanisms offset disability-related detriments. This may be by way of sympathetic reflex activity, receptor hypersensitivity, or parasympathetic and neuroendocrine adjustments. Future work needs to explore these mechanisms further to clarify the implications of an SCI on the immune response to exercise and susceptibility to infection. In this article, we review the impacts of an SCI on immune, and specifically, exercise immune function. The relevant anatomical and physiological foundations of the immune system are first briefly laid out in order to understand the potential impacts of neural and neuroendocrine dysfunction on the immune system. With the limited number of human studies available, we have then aimed specifically to gather all relevant existing literature on exercise immunology in individuals with an SCI in patient, recreationally active and athlete populations. We believe that an understanding of the impacts of exercise can provide a tool to help maintain or improve health in individuals with an SCI. A comprehensive literature search was conducted using the search engines PubMed, SPORTDiscus, Web of Science and Zetoc, search period June 2012-February 2013. Key words employed included spinal cord injury, immunology, exercise, paraplegic, tetraplegic, upper body exercise, interleukin, immunoglobulin, sympathetic, and parasympathetic. All articles and articles derived from their reference lists were checked for their suitability.

脊髓损伤(SCI)可通过影响免疫功能的许多方面而增加感染的风险;一个特别有证据的观察结果是淋巴细胞数量减少。绝大多数淋巴样细胞表达肾上腺素能受体。因此,自主神经功能丧失和伴随的静息和运动后儿茶酚胺浓度的改变,特别是在四肢瘫痪患者中,可能直接影响免疫细胞并抑制免疫力。其他因素也可能有影响,例如脊髓损伤后肌肉、内分泌和心血管功能的改变。然而,一些改变,如在四肢瘫痪者运动后自然杀伤细胞毒性的增加,与儿茶酚胺反应无关。同样,四肢瘫痪患者的粘膜免疫似乎与健康人一样受到运动的影响。事实上,康复治疗和锻炼可以提高脊髓损伤患者的免疫和自主神经功能。因此,补偿机制有可能抵消与残疾有关的损害。这可能是通过交感反射活动,受体超敏,或副交感神经和神经内分泌调节的方式。未来的工作需要进一步探索这些机制,以阐明脊髓损伤对运动免疫反应和感染易感性的影响。在本文中,我们综述了脊髓损伤对免疫的影响,特别是对运动免疫功能的影响。为了了解神经和神经内分泌功能障碍对免疫系统的潜在影响,本文首先简述了免疫系统的相关解剖学和生理学基础。由于可用的人体研究数量有限,我们的目标是专门收集所有与脊髓损伤患者、娱乐活动人群和运动员人群的运动免疫学相关的现有文献。我们相信,了解运动的影响可以提供一种工具,帮助维持或改善脊髓损伤患者的健康。利用PubMed、SPORTDiscus、Web of Science和Zetoc等搜索引擎进行全面的文献检索,检索期为2012年6月至2013年2月。关键词:脊髓损伤、免疫学、运动、截瘫、四肢瘫痪、上肢运动、白细胞介素、免疫球蛋白、交感神经和副交感神经。检查所有文章及其参考文献列表中的文章的适用性。
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引用次数: 0
Cytokine kinetics in nasal mucosa and sera: new insights in understanding upper-airway disease of marathon runners. 鼻黏膜和血清中的细胞因子动力学:了解马拉松运动员上呼吸道疾病的新见解。
IF 7.3 4区 医学 Q1 Medicine Pub Date : 2013-01-01
Mauro Vaisberg, Vinicius M Suguri, Luiz C Gregorio, Jose D Lopes, André L L Bachi

Recently, many authors have proposed that mechanisms such as inflammation and/or allergies could be partly responsible for cases of upper respiratory tract illnesses that affect athletes after exhaustive exercise. Here we studied the kinetics of cytokines in the serum and nasal mucosa of athletes after a marathon. We were able to demonstrate an increase in serum levels of all interleukins studied immediately after the marathon in athletes that present or not with upper airways symptoms followed by a return to basal levels 72 hours after the race, as described in the literature. Interleukin (IL)-10 behaviour differed in the group of asymptomatic athletes. Measurement of this cytokine in protein extract of nasal mucosal cells showed increase 72 hours after the marathon. Levels of this cytokine in sera were increased at rest in athletes that did not present symptoms. These fin- dings suggest that the maintenance of a non-inflammatory environment in the mucosal airways is an active process that requires participation of the systemic and mucosal immune systems. We propose that the understanding of the upper airway disease of the athlete involves the study of mucosal and systemic immune systems.

最近,许多作者提出,炎症和/或过敏等机制可能是导致运动员在剧烈运动后出现上呼吸道疾病的部分原因。在这里,我们研究了马拉松运动员血清和鼻黏膜细胞因子的动力学。正如文献所述,我们能够证明,在马拉松比赛后,无论是否出现上呼吸道症状,运动员的血清中所有白细胞介素水平都会立即升高,并在比赛后72小时恢复到基础水平。白细胞介素(IL)-10的行为在无症状运动员组中有所不同。这种细胞因子在鼻粘膜细胞蛋白提取物中的测量显示,马拉松后72小时增加。在没有出现症状的运动员休息时,血清中这种细胞因子的水平升高。这些发现表明,维持粘膜气道的非炎症环境是一个主动的过程,需要全身和粘膜免疫系统的参与。我们建议对运动员上呼吸道疾病的了解包括对粘膜和全身免疫系统的研究。
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引用次数: 0
Influence of vitamin D status on respiratory infection incidence and immune function during 4 months of winter training in endurance sport athletes. 耐力运动运动员冬训4个月期间维生素D水平对呼吸道感染发生率和免疫功能的影响
IF 7.3 4区 医学 Q1 Medicine Pub Date : 2013-01-01
Cheng-Shiun He, Michal Handzlik, William D Fraser, Ayu Muhamad, Hannah Preston, Andrew Richardson, Michael Gleeson

The purpose of this study was to examine the influence of vitamin D status on mucosal and systemic immunity and the incidence, severity and duration of upper respiratory tract illness (URTI) episodes in endurance athletes during a 16-week winter training period. Blood was collected from 225 subjects at the start of the study and plasma was analysed for total 25-hydroxy vitamin D (25(OH)D) and cathelicidin concentration. Blood was also collected at the end of the study and analysed for 25(OH)D and antigen-stimulated cytokine production. Unstimulated saliva samples were obtained at the start and at 4-week intervals during the study period. Saliva samples were analysed for salivary antimicrobial peptides and proteins (AMPs). Weekly training and daily illness logs were kept. At the start and end of the study 38% and 55%, respectively, of the athlete cohort had inadequate (plasma 25(OH)D 30-50 nmol/L) or deficient (plasma 25(OH)D < 30 nmol/L) vitamin D status. There was a significantly higher proportion of subjects who presented with symptoms of URTI in the vitamin D deficient status group (initial plasma 25(OH)D < 30 nmol/L) during the study period than in the optimal vitamin D group (> 120 nmol/L) and the total number of URTI symptom days and the median symptom-severity score in the vitamin D deficient group was signifi- cantly higher than in the other groups. The plasma cathelicidin concentration positively correlated with the plasma 25(OH)D concentration and the saliva secretory immunoglobulin A (SIgA) secretion rate in the optimal vitamin D status group was significantly higher than in the other groups. Low vitamin D status was associated with lower pro-inflammatory cytokine production by monocytes and lymphocytes. Low vitamin D status could be an important determinant of URTI risk in endurance athletes and mucosal as well as systemic immunity may be modified via vitamin D-dependent mechanisms.

本研究的目的是检查维生素D状态对粘膜和全身免疫的影响,以及耐力运动员在16周冬季训练期间上呼吸道疾病(URTI)发作的发生率、严重程度和持续时间。在研究开始时收集了225名受试者的血液,并分析了血浆中25-羟基维生素D (25(OH)D)和抗菌肽的浓度。在研究结束时还收集了血液,并分析了25(OH)D和抗原刺激的细胞因子的产生。在研究开始时和研究期间每隔4周采集一次未受刺激的唾液样本。分析唾液样本中的抗菌肽和抗菌蛋白(AMPs)。每周培训和每日疾病记录。在研究开始和结束时,分别有38%和55%的运动员队列维生素D不足(血浆25(OH)D 30-50 nmol/L)或缺乏(血浆25(OH)D < 30 nmol/L)。在研究期间,维生素D缺乏组(初始血浆25(OH)D < 30 nmol/L)出现尿路感染症状的受试者比例明显高于最佳维生素D组(> 120 nmol/L),维生素D缺乏组尿路感染症状总天数和中位症状严重程度评分显著高于其他组。维生素D最佳状态组血浆抗菌肽浓度与血浆25(OH)D浓度、唾液分泌免疫球蛋白A (SIgA)分泌率呈正相关,显著高于其他各组。低维生素D状态与单核细胞和淋巴细胞产生的促炎细胞因子降低有关。低维生素D状态可能是耐力运动员尿路感染风险的重要决定因素,粘膜和全身免疫可能通过维生素D依赖机制被改变。
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Exercise Immunology Review
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