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An Insidious Comorbidity: Depression and Chronic Heart Failure 一种隐匿的并发症:抑郁症与慢性心力衰竭
Pub Date : 2024-02-06 DOI: 10.18662/brain/15.1/566
A. Petris
Depression and heart failure (HF) are in a close bilateral relationship: the appearance of one is potentiated by the other entity and the effects on the outcome are amplified within this ”dangerous liaison”. Depression is present in about one in five HF patients and is severe in almost half of them. The risk factors for depression in HF are female gender, elderly, the severity of HF symptoms, a history of isolated systolic hypertension or coronary heart disease (CHD), previous hospitalization and previous depressive episodes. Depression in HF patients increases medication non-adherence, is associated with poor outcomes after heart transplantation and is predictive of events and mortality in cardiac resynchronization therapy (CRT). The current assumptions related to the physiopathological mechanisms include a common genetic polymorphisms, inflammation, generalized immune system disturbance, disturbances of platelet function, increased catecholamine levels, deamination of monoamines linked with monoamine oxidase activity, a dysregulation of the autonomic nervous system, increased serotonin levels, ischemia, life-style and medication non-compliance, a poor familial support and social isolation. Assessment of cognitive functioning should be part of routine clinical examination in HF, the diagnosis of depression is based on questionnaires (e.g. Patient Health Questionnaire-2 - PHQ-2) and on clinical interview. There is still no consensus on the best therapy for HF patients with depression (non-pharmacological and pharmacological therapies) but, for sure, depression in HF is harder to treat.
抑郁症和心力衰竭(HF)之间存在着密切的双边关系:一方的出现会因另一方的出现而加剧,对治疗结果的影响也会在这种 "危险的联系 "中放大。每五名高血压患者中就有一人患有抑郁症,其中近一半的患者病情严重。高血压抑郁症的危险因素包括女性、老年人、高血压症状严重程度、孤立的收缩期高血压或冠心病(CHD)病史、既往住院史和既往抑郁发作史。心房颤动患者的抑郁会增加服药的不依从性,与心脏移植术后的不良预后有关,并可预测心脏再同步化治疗(CRT)的事件和死亡率。目前与生理病理机制有关的假设包括常见的基因多态性、炎症、全身免疫系统紊乱、血小板功能紊乱、儿茶酚胺水平升高、与单胺氧化酶活性有关的单胺类物质脱氨、自主神经系统失调、血清素水平升高、缺血、生活方式和不遵医嘱用药、家庭支持不足和社会隔离。对认知功能的评估应作为高血压常规临床检查的一部分,抑郁症的诊断基于问卷调查(如患者健康问卷-2 - PHQ-2)和临床访谈。对于高血压抑郁症患者的最佳疗法(非药物疗法和药物疗法),目前仍未达成共识,但可以肯定的是,高血压抑郁症更难治疗。
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引用次数: 0
Comparison of Educational Development Trends in Ukraine and the World 乌克兰与世界教育发展趋势比较
Pub Date : 2024-02-06 DOI: 10.18662/brain/15.1/542
Anatolii Maksymenko, Olena Otych, Valerii Polishchuk, Yurii Skyba, Nataliia Savchenko, Tetiana Okushko
The article examines the trends in the development of the educational system in recent years in Ukraine and the world in the context of neuropedagogy. Particular attention is paid to the factors that have influenced the strengthening of the role of education in the world, in particular, the strengthening of the state's interest in financing education. The article updates the inextricable connection between the country's economy and the level and quality of education. The author points out the advantages of education support systems in some advanced countries of the world, which can be used as a model experience for domestic educational reform, in particular due to the use of neuropedagogy. The most important trends in the development of education in the world educational space are analyzed. The author notes that the quarter-century experience of the 21st century civilization determines a number of trends according to which it should develop in the future. Among them, for example, the transition of most nations and cultures to market relations is leading in the economy; in politics - to democracy; in social communication - to tolerance; in the general organization of life activities - to an open society and models of sustainable human development, etc. Because education (and science), which prepares a person for independent life, shapes his view on the future development of civilization.
文章从神经教育学的角度探讨了近年来乌克兰和世界教育体系的发展趋势。文章特别关注了影响世界教育作用加强的因素,尤其是国家对教育经费投入兴趣的加强。文章更新了国家经济与教育水平和质量之间密不可分的联系。作者指出了世界上一些先进国家的教育支持系统的优势,这些系统可以作为国内教育改革的示范经验,特别是由于使用了神经教育学。作者分析了世界教育领域最重要的教育发展趋势。作者指出,21 世纪文明四分之一世纪的经验决定了其未来发展应遵循的若干趋势。例如,在经济领域,大多数国家和文化都在向市场关系过渡;在政治领域,向民主过渡;在社会交流领域,向宽容过渡;在生活活动的总体组织领域,向开放社会和人类可持续发展模式过渡,等等。因为教育(和科学)是培养人独立生活的工具,它决定了人对未来文明发展的看法。
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引用次数: 0
The Role of Current Computer Technologies in Developing Professional Competence of Music Teachers: A Model of a Personalized Educational Environment 当前计算机技术在培养音乐教师专业能力中的作用:个性化教育环境模式
Pub Date : 2024-02-06 DOI: 10.18662/brain/15.1/554
Oleksii Pavlenko, T. Rastruba, Larysa Huseinova, Leonid Khomenko, Khrystyna Pelekh, Olena Koval
The importance of the article lies in the fact that the profession of school music teacher today needs to create its own updated competence model of personal educational environment taking into account digital transformation and computerization of general education. The information competence of the music teacher, the issues of his professional development in working with music and computer technologies are taken into account. Analyzed the possibility of building a personal educational environment in the era of postmodern (including electronic) and their application in further professional activities. The author analyzes the possibility of introducing modern computer technology as a resource for the formation of musical needs of the teacher of the educational institution. In addition to professional competencies, some general requirements for music teachers today, which can be grouped into four groups: general professional, communicative, behavioral and analytical. The article presents a model of university music education in the postmodern era; ways of acquiring professional competence of a music teacher are considered; the stages of creating a model of personal educational environment of a music teacher in the postmodern era are described; the role of professional competence of a music teacher in the postmodern personal educational environment model is defined; the role of current music and computer technologies (MCT) in creating a model of personal educational environment of a music teacher was determined.
文章的重要性在于,当今的学校音乐教师职业需要结合普通教育的数字化转型和计算机化,创建自己最新的个人教育环境能力模型。文章考虑了音乐教师的信息能力、他在音乐和计算机技术工作中的专业发展问题。分析了在后现代(包括电子)时代建立个人教育环境的可能性及其在进一步专业活动中的应用。作者分析了引入现代计算机技术作为教育机构教师音乐需求形成资源的可能性。除专业能力外,当今对音乐教师的一些一般要求可分为四类:一般专业能力、交际能力、行为能力和分析能力。文章介绍了后现代大学音乐教育模式;考虑了音乐教师获得专业能力的途径;描述了创建后现代音乐教师个人教育环境模式的阶段;界定了音乐教师专业能力在后现代个人教育环境模式中的作用;确定了当前音乐和计算机技术(MCT)在创建音乐教师个人教育环境模式中的作用。
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引用次数: 0
Reading Neurocognitive Disorder 阅读神经认知障碍
Pub Date : 2024-02-06 DOI: 10.18662/brain/15.1/546
Liliana Mihailov, I. Diaconu, Vlad Ichim, Mihai Mutică, Bogdan Pîrvu, Vladimir Poroch
The multiple uses of Humanities in teaching Medicine need hardly detailing; suffice to say that a number of top Medical Schools have included Medical Humanities in their curricula. In this context we will consider the way Eugène Ionesco can be put to good use when it comes to teaching neurocognitive disorder; his theatre, come to think of “The Bald Soprano,” focuses on non-sequiturs, dislocated language and distorted logic – all of these being unfailing expressions of a cognitive impairment or even demise.
人文科学在医学教学中的多重用途无需赘述,只需指出一些顶级医学院已将医学人文科学纳入其课程即可。在此背景下,我们将考虑欧仁-尤涅斯库(Eugène Ionesco)在神经认知障碍教学中的妙用;他的戏剧《秃头女高音》(The Bald Soprano)侧重于无序、错位的语言和扭曲的逻辑--所有这些都是认知障碍甚至消亡的不二表现。
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引用次数: 0
The Role of Computer Technologies in Music Teacher Training: Implementing the Humane Education Strategy 计算机技术在音乐教师培训中的作用:实施人性化教育战略
Pub Date : 2024-02-06 DOI: 10.18662/brain/15.1/557
Olena Priadko, Olena Aliksiichuk, Tetiana Borysova, Svitlana Chaban-Chayka, L. Onofriichuk, Viktoriia Fedorchuk
The ever-evolving nature of society dictates educational policies, which is mirrored in the challenges of training music teachers in higher education. Pedagogical universities are constantly investigating ways to revolutionize education and introduce new pedagogical tools. This article analyzes the experiences, difficulties and directions of music teacher training in the scope of the humane education strategy. Surveying the condition of music education, its current status and potential for progress has demonstrated that the career of a musician-educator is and will remain in high demand as long as it is augmented with new professional content. This can be used to broaden the role of a music teacher in both regular and extra schooling, such as designing and implementing numerous musical and creative progression programmes. Importantly, the article delves into the issue of developing a model for teaching information technologies to future music teachers, which follows an interdisciplinary and context-oriented content selection principle. It advocates for a comprehensive approach to shaping a continuous sequence of educational subjects throughout the entire period of university education. It also highlights the integration of music and computer technologies as a means of teaching information technology and as a subject for study. Finally, the article highlights the significance of computer technologies in training future music teachers as there is a growing demand for music education specialists who are proficient in the technological processes associated with music software and can effectively employ computer technologies in their professional duties.
社会的不断发展决定了教育政策的不断变化,这也反映在高等教育中音乐教师培训所面临的挑战上。师范大学不断研究如何革新教育和引入新的教学工具。本文分析了人性化教育战略范围内音乐教师培训的经验、困难和方向。对音乐教育的状况、现状和发展潜力的调查表明,只要增加新的专业内容,音乐教育工作者的职业现在和将来都会有很大的需求。这可用于拓宽音乐教师在正规和非正规学校教育中的作用,如设计和实施众多音乐和创造性进步计划。重要的是,文章深入探讨了为未来音乐教师开发信息技术教学模式的问题,该模式遵循跨学科和以情境为导向的内容选择原则。文章主张在整个大学教育期间,采用综合方法塑造连续的教育科目序列。文章还强调了音乐与计算机技术的整合,将其作为信息技术教学的一种手段和一门研究课题。最后,文章强调了计算机技术对培养未来音乐教师的重要意义,因为对精通与音乐软件相关的技术流程并能在其专业职责中有效运用计算机技术的音乐教育专家的需求日益增长。
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引用次数: 0
Resilience and Emotional Comfort in a Pandemic Through Philosophical Counselling. Experimental Study. 通过哲学咨询提高大流行病中的复原力和情感慰藉。实验研究。
Pub Date : 2024-02-06 DOI: 10.18662/brain/15.1/548
Adela Moldovan, D. Sîmbotin
By undertaking “theōría-práxis” research, this paper aims to: define the key concepts involved in philosophical counselling and examine the effectiveness of philosophical approaches in the context of implementing a philosophical counselling program to reduce the level of emotional distress felt in the context of the Sars pandemic-Cov2. In this sense, I have made a lexicography of the articulations of thought, which are philosophical approaches and philosophical resources, used as therapeutic prescriptions, which have proven their effectiveness in the path of wisdom.
通过开展 "theōría-práxis "研究,本文旨在:定义哲学咨询所涉及的关键概念,并在实施哲学咨询计划以降低萨斯大流行病(Cov2)背景下的情绪困扰程度的背景下,研究哲学方法的有效性。 从这个意义上说,我已经编制了一份思想表述词典,这些思想表述是哲学方法和哲学资源,用作治疗处方,已被证明在智慧的道路上行之有效。
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引用次数: 0
The Power of Religious Faith as a Predictor of Autonomy, Community, and Divinity Ethical Values 宗教信仰对自主性、社区性和神性伦理价值观的影响
Pub Date : 2024-02-06 DOI: 10.18662/brain/15.1/553
R. Nicoară, Nicoară Ana-Maria, Popescu Codruța Alina
This article investigates the influence of religious faith on ethical values (autonomy, community, and divinity), and specifically considers the predictive role in shaping individuals' orientations toward autonomy, community, and divinity. Study examines the ways in which adherence to religious beliefs molds ethical perspectives. The research employs a multidimensional framework to assess the correlation between religious faith and values associated with personal autonomy, communal responsibility, and the sacred. Understanding the power of religious faith as a predictor of ethical values has implications for fostering a deeper comprehension of diverse moral frameworks and facilitating interfaith dialogue. The article underscores the importance of recognizing and respecting the role of religious beliefs in shaping ethical convictions, thereby contributing to a more inclusive and informed discourse on morality in a pluralistic society.
本文探讨了宗教信仰对伦理价值观(自主性、群体性和神性)的影响,并特别考虑了宗教信仰在塑造个人的自主性、群体性和神性取向方面的预测作用。研究探讨了宗教信仰如何塑造伦理观。研究采用多维框架来评估宗教信仰与个人自主、社区责任和神圣等相关价值观之间的关联。了解宗教信仰作为伦理价值观预测因素的力量,对于促进深入理解不同的道德框架和促进不同信仰间的对话具有重要意义。文章强调了承认和尊重宗教信仰在塑造道德信念方面所起作用的重要性,从而有助于在多元化社会中就道德问题展开更具包容性和知情的讨论。
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引用次数: 0
Resilience and Emotional Comfort in a Pandemic Through Philosophical Counselling. Experimental Study. 通过哲学咨询提高大流行病中的复原力和情感慰藉。实验研究。
Pub Date : 2024-02-06 DOI: 10.18662/brain/15.1/548
Adela Moldovan, D. Sîmbotin
By undertaking “theōría-práxis” research, this paper aims to: define the key concepts involved in philosophical counselling and examine the effectiveness of philosophical approaches in the context of implementing a philosophical counselling program to reduce the level of emotional distress felt in the context of the Sars pandemic-Cov2. In this sense, I have made a lexicography of the articulations of thought, which are philosophical approaches and philosophical resources, used as therapeutic prescriptions, which have proven their effectiveness in the path of wisdom.
通过开展 "theōría-práxis "研究,本文旨在:定义哲学咨询所涉及的关键概念,并在实施哲学咨询计划以降低萨斯大流行病(Cov2)背景下的情绪困扰程度的背景下,研究哲学方法的有效性。 从这个意义上说,我已经编制了一份思想表述词典,这些思想表述是哲学方法和哲学资源,用作治疗处方,已被证明在智慧的道路上行之有效。
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引用次数: 0
Etiological Factors and Parental Coping in Congenital Heart Malformations 先天性心脏畸形的病因和父母的应对措施
Pub Date : 2024-02-06 DOI: 10.18662/brain/15.1/547
Ș. Moisa, L. Butnariu, C. Rîpă, R. Cobzaru, Laura Trandafir
The etiology of congenital heart malformations is still insufficiently known. Many genetic mutations exert their action through various mechanisms on neural crest signaling, acting on neural cell migration and altering bulboconal region formation or resorbtion. Some studies evaluate the role of punctual or noncoding mutations, while others highlight the teratogen effect of retinoic acid or ethanol, or discuss the role of maternal diabetes or pregnancy rubella. The etiology of congenital heart malformations is complex and multifactorial and requires further studies. The impact on the family of a child with a congenital heart malformation is significant and various coping mechanisms are employed by parents to address the issue.
先天性心脏畸形的病因尚不十分清楚。许多基因突变通过各种机制对神经嵴信号转导、神经细胞迁移、球冠区形成或吸收产生作用。一些研究评估了点状突变或非编码突变的作用,另一些研究则强调了维甲酸或乙醇的致畸作用,或讨论了母体糖尿病或妊娠风疹的作用。先天性心脏畸形的病因复杂且多因素,需要进一步研究。先天性心脏畸形患儿对家庭的影响是巨大的,家长会采用各种应对机制来解决这一问题。
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引用次数: 0
Study on the Impact of Depression on the Quality of Life of Patients With Psoriasis 抑郁症对银屑病患者生活质量影响的研究
Pub Date : 2024-02-06 DOI: 10.18662/brain/15.1/568
Roxana-Cristina Oltenacu, Gabriela Stoleriu, Lucreţia Anghel, I. Chiscop, Anamaria Ciubara
Introduction: Psoriasis is a chronic condition with a strong impact on the daily life of patients, especially on relationship life. This paper aims to clarify the impact of depression on the quality of life of patients with moderate psoriasis. Methods: A cross-sectional study was conducted on 16 participants with psoriasis from April to May 2023. Patients with psoriasis vulgaris completed self-administered questionnaires which include demographic characteristics, Hamilton Depression Rating Scale (HAM-D) and Dermatological Life Quality Index (DLQI). Data were collected both physically, during periodic checks and online by email. Only 16 patients met the eligibility criteria for study entry. All patients included in the study had moderate psoriasis vulgaris. Exclusion criteria for participation in the study was: current use of psychotropic medications. severe comorbidities or chronic medical conditions and visual, auditory, linguistic, or cognitive impairments. Results: After completed the Hamilton Depression Rating Scale (HAM-D) half of them 8 (50%) had a score lower than 8 (minimal depression) and the other half  8 (50%) between 8-16 (mild depression). 14 (87.5%) of the participants had a DLQI score of more than 10, indicating severe impairment in their quality of life. The results obtained showed a positive correlation between Dermatological Life Quality Index (DLQI) andHamilton Depression Rating Scale (HAM-D). Conclusions: Depressive manifestations significantly influence the quality of life of psoriasis patients analyzed. A multidisciplinary approach in treating the patient with psoriasis is indispensable because it is not only necessary to manage a disease or a "case", but also to manage a patient.  
导言银屑病是一种慢性疾病,对患者的日常生活,尤其是感情生活有很大影响。本文旨在阐明抑郁症对中度银屑病患者生活质量的影响。研究方法于 2023 年 4 月至 5 月对 16 名银屑病患者进行了横断面研究。寻常型银屑病患者填写了自填问卷,其中包括人口统计学特征、汉密尔顿抑郁量表(HAM-D)和皮肤病生活质量指数(DLQI)。数据收集方式有两种,一种是通过身体检查,另一种是通过电子邮件在线收集。只有 16 名患者符合研究入选标准。所有参与研究的患者均患有中度寻常型银屑病。参加研究的排除标准是:目前正在使用精神药物;严重的合并症或慢性疾病;视觉、听觉、语言或认知障碍。研究结果完成汉密尔顿抑郁评定量表(HAM-D)后,其中一半 8 人(50%)的得分低于 8 分(轻度抑郁),另一半 8 人(50%)的得分在 8-16 分之间(轻度抑郁)。有 14 人(87.5%)的 DLQI 得分超过 10 分,表明他们的生活质量受到严重影响。结果显示,皮肤病生活质量指数(DLQI)与汉密尔顿抑郁量表(HAM-D)之间存在正相关。结论是抑郁表现严重影响了银屑病患者的生活质量。治疗银屑病患者的多学科方法是不可或缺的,因为这不仅是管理疾病或 "病例 "的需要,也是管理患者的需要。
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引用次数: 0
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BRAIN. Broad Research in Artificial Intelligence and Neuroscience
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