Pub Date : 2009-05-01DOI: 10.1177/17418267090160s111
F. Sofi, G. Pratesi, R. Pulli, C. Pratesi, T. Suvorava, M. Weber, S. Valcaccia, Thao-Vi Dao, G. Kojda, M. Oppermann
O397 Balance between circulating endothelial progenitor cells (EPCs) and mature circulating endothelial cells (CECs) in relation to the severity of peripheral arterial disease FCesari, F Sofi, RCaporale, G Pratesi, R Pulli, C Pratesi, RAbbate, GFGensini University of Florence, Florence, Italy, Azienda Ospedaliero-Universitaria Careggi, Florence, Italy Topic: Peripheral vascular disease Introduction: the maintenance of endothelial health depends, not only on the local milieu, but also on circulating endothelial progenitor cells (EPCs) derived from the bone marrow. Indeed, EPCs support the integrity of vascular endothelium and promote revascularisation of ischemic areas. On the other hand, circulating mature endothelial cells (CECs) are considered a marker of endothelial injury. Previous studies demonstrated reduced number of EPCs in peripheral arterial disease (PAD) patients, but few data are available on CECs. Aim of our study was to contemporary assess EPCs and CECs in PAD patients in relation to the severity of the disease. Methods: in 30 PAD patients [22 M/ 8 F; median age: 69 (45-86) years] we measured circulating EPCs and CECs by using flow cytometry. EPCs were defined as CD34+KDR+, CD133+KDR+ and CD34+CD133+KDR+, while CECs were defined as CD146+/CD31+/CD45-/CD61-. Results: a significant trend of decrease (p<0.05) in relation to the clinical severity of the disease, as seen by Fontaine’s stages, was observed for CD133+/KDR+ EPCs [stage IIa: 0.093 (0.060.25); stage IIb: 0.049 (0.02-0.16); stage III: 0.03 (0.02-0.05); stage IV: 0.035 (0.02-0.08) cells/ ÿ ÙL]. On the contrary, a significant (p<0.05) increase was showed by CECs [stage IIa: 0.077 (0.02-0.13); stage IIb: 0.084 (0.02-0.19); stage III: 0.15 (0.05-0.19); stage IV: 0.22 (0.08-0.33) cells/ ÿ ÙL]. In order to evaluate the balance existing between EPCs and CECs in relation to the clinical progression of the disease, we calculated the CECs/EPCs ratio. By increasing Fontaine’s stage, a progressive and significant (p<0.05) increase in ratio value was observed, indicating a prominent role of CECs with respect to EPCs number [stage IIa: 0.62 (0.2-2.30); stage IIb: 1.22 (0.23-7.67); stage III: 6.39 (1.43-7.71); stage IV: 6.14 (1-16)] Conclusions: our results demonstrate an inbalance between EPCs and CECs in PAD patients in relation to the progression of the disease, possibly indicating that the endothelial damage observed in these patients is not sufficiently repaired by a concomitant increase of the regenerative capacity of EPCs.
O397循环内皮祖细胞(EPCs)和成熟循环内皮细胞(CECs)之间的平衡与周围动脉疾病严重程度的关系FCesari, F Sofi, RCaporale, G Pratesi, R Pulli, C Pratesi, RAbbate, GFGensini佛罗伦萨大学，佛罗伦萨，意大利，Azienda Ospedaliero-Universitaria Careggi，佛罗伦萨主题:周围血管疾病内皮健康的维持不仅依赖于局部环境，还依赖于来自骨髓的循环内皮祖细胞(EPCs)。事实上，内皮祖细胞支持血管内皮的完整性，促进缺血区域的血运重建。另一方面，循环成熟内皮细胞(CECs)被认为是内皮损伤的标志。先前的研究表明外周动脉疾病(PAD)患者EPCs数量减少，但关于CECs的数据很少。我们研究的目的是评估PAD患者EPCs和CECs与疾病严重程度的关系。方法:30例PAD患者[22 M/ 8 F;中位年龄:69(45-86岁)。我们使用流式细胞术测量循环EPCs和CECs。EPCs定义为CD34+KDR+、CD133+KDR+和CD34+CD133+KDR+， CECs定义为CD146+/CD31+/CD45-/CD61-。结果:从Fontaine分期来看，CD133+/KDR+ EPCs与疾病的临床严重程度有显著的下降趋势(p<0.05) [IIa期:0.093 (0.060.25);IIb期:0.049 (0.02-0.16);III期:0.03 (0.02-0.05);IV期:0.035 (0.02-0.08)cells/¾ÙL]。与此相反，CECs显著升高(p<0.05) [IIa期:0.077 (0.02-0.13);IIb期:0.084 (0.02-0.19);第三阶段:0.15 (0.05-0.19);IV期:0.22(0.08-0.33)个细胞/¾ÙL]。为了评估EPCs和CECs之间存在的平衡与疾病临床进展的关系，我们计算了CECs/EPCs比值。随着Fontaine分期的增加，比值值渐进式显著增加(p<0.05)，表明CECs对EPCs数量的影响显著[分期:0.62 (0.2-2.30);IIb期:1.22 (0.23-7.67);III期:6.39 (1.43-7.71);结论:我们的研究结果表明，PAD患者中EPCs和CECs之间的不平衡与疾病的进展有关，可能表明在这些患者中观察到的内皮损伤并没有通过EPCs再生能力的增加得到充分修复。
{"title":"Oral Session IV. Translational cardiovascular science","authors":"F. Sofi, G. Pratesi, R. Pulli, C. Pratesi, T. Suvorava, M. Weber, S. Valcaccia, Thao-Vi Dao, G. Kojda, M. Oppermann","doi":"10.1177/17418267090160s111","DOIUrl":"https://doi.org/10.1177/17418267090160s111","url":null,"abstract":"O397 Balance between circulating endothelial progenitor cells (EPCs) and mature circulating endothelial cells (CECs) in relation to the severity of peripheral arterial disease FCesari, F Sofi, RCaporale, G Pratesi, R Pulli, C Pratesi, RAbbate, GFGensini University of Florence, Florence, Italy, Azienda Ospedaliero-Universitaria Careggi, Florence, Italy Topic: Peripheral vascular disease Introduction: the maintenance of endothelial health depends, not only on the local milieu, but also on circulating endothelial progenitor cells (EPCs) derived from the bone marrow. Indeed, EPCs support the integrity of vascular endothelium and promote revascularisation of ischemic areas. On the other hand, circulating mature endothelial cells (CECs) are considered a marker of endothelial injury. Previous studies demonstrated reduced number of EPCs in peripheral arterial disease (PAD) patients, but few data are available on CECs. Aim of our study was to contemporary assess EPCs and CECs in PAD patients in relation to the severity of the disease. Methods: in 30 PAD patients [22 M/ 8 F; median age: 69 (45-86) years] we measured circulating EPCs and CECs by using flow cytometry. EPCs were defined as CD34+KDR+, CD133+KDR+ and CD34+CD133+KDR+, while CECs were defined as CD146+/CD31+/CD45-/CD61-. Results: a significant trend of decrease (p<0.05) in relation to the clinical severity of the disease, as seen by Fontaine’s stages, was observed for CD133+/KDR+ EPCs [stage IIa: 0.093 (0.060.25); stage IIb: 0.049 (0.02-0.16); stage III: 0.03 (0.02-0.05); stage IV: 0.035 (0.02-0.08) cells/ ÿ ÙL]. On the contrary, a significant (p<0.05) increase was showed by CECs [stage IIa: 0.077 (0.02-0.13); stage IIb: 0.084 (0.02-0.19); stage III: 0.15 (0.05-0.19); stage IV: 0.22 (0.08-0.33) cells/ ÿ ÙL]. In order to evaluate the balance existing between EPCs and CECs in relation to the clinical progression of the disease, we calculated the CECs/EPCs ratio. By increasing Fontaine’s stage, a progressive and significant (p<0.05) increase in ratio value was observed, indicating a prominent role of CECs with respect to EPCs number [stage IIa: 0.62 (0.2-2.30); stage IIb: 1.22 (0.23-7.67); stage III: 6.39 (1.43-7.71); stage IV: 6.14 (1-16)] Conclusions: our results demonstrate an inbalance between EPCs and CECs in PAD patients in relation to the progression of the disease, possibly indicating that the endothelial damage observed in these patients is not sufficiently repaired by a concomitant increase of the regenerative capacity of EPCs.","PeriodicalId":50492,"journal":{"name":"European Journal of Cardiovascular Prevention & Rehabilitation","volume":"16 1","pages":"S86 - S87"},"PeriodicalIF":0.0,"publicationDate":"2009-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/17418267090160s111","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"65490805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2009-05-01DOI: 10.1177/17418267090160s103
J. Skoumas, K. Aznaouridis, VMetaxa, F. Platsouka, L. Papadimitriou, C. Pitsavos, C. Stefanadis, M. Lorgeril, P. Salen, F. Laporte, A. Castelnuovo, V. Krogh, M. Donati, A. Tverdal, F. Visseren, A. Algra
M135 Metabolic syndrome is a predictor of outcome in patients with familial combined hyperlipidemia CMasoura, J Skoumas, K Aznaouridis, VMetaxa, F Platsouka, L Papadimitriou, C Pitsavos, C Stefanadis Athens, Greece Topic: Lipids and atherosclerosis Purpose: Familial combined hyperlipidemia (FCH) is a polygenic lipid disorder associated with premature cardiovascular disease. It is unknown whether metabolic syndrome (MetS) modulates cardiovascular risk in FCH patients. Methods: We studied prospectively 644 FCH patients (421 men) for 9.2 3.6 years. Demographic characteristics and biochemical parameters were evaluated at enrolment, before the initiation of treatment. The diagnosis of MetS was based on the modified ATP III criteria (glucose >100 mg/dl). Hard cardiovascular end-points, like acute myocardial infarction (AMI) and cardiovascular death, were recorded during the follow-up. Results: The 323 patients with MetS were older (50.8 10.2 vs. 46.7 11.0 years, öÀ<0.001) and had higher triglyceride and glucose levels, but they had lower HDL-C levels compared with patients without MetS (all öÀ<0.001). There was no difference in total cholesterol. The combined endpoint (AMI/death) occurred in 29 patients with MetS and in 9 patients without MetS (9.0% vs. 2.8%, P=0.001). Kaplan-Meier analysis showed a significant difference in the event-free survival between the 2 groups (P=0.005, figure). Multivariate analysis (Cox regression) showed that MetS at enrolment predicts AMI/death independent of age, sex or previous cardiovascular disease (adjusted odds ratio 2.25, 95% CI 1.06-4.75, P=0.034). Conclusions: MetS represents an independent predictor of major cardiovascular events in FCH patients.
M135代谢综合征是家族性合并高脂血症患者预后的预测因子CMasoura, J Skoumas, K Aznaouridis, VMetaxa, F Platsouka, L Papadimitriou, C Pitsavos, C Stefanadis主题:脂质与动脉粥样硬化目的:家族性合并高脂血症(FCH)是一种与早发心血管疾病相关的多基因脂质疾病。目前尚不清楚代谢综合征(MetS)是否调节FCH患者的心血管风险。方法:我们对644例FCH患者(421例男性)进行了9.2 3.6年的前瞻性研究。在开始治疗前，在入组时评估人口统计学特征和生化参数。MetS的诊断基于改进的ATP III标准(葡萄糖> 100mg /dl)。在随访期间记录硬心血管终点，如急性心肌梗死(AMI)和心血管死亡。结果:323例MetS患者年龄较大(50.8 - 10.2岁vs. 46.7 - 11.0岁，öÀ<0.001)，甘油三酯和葡萄糖水平较高，但与没有MetS的患者相比，他们的HDL-C水平较低(均öÀ<0.001)。总胆固醇没有差异。合并终点(AMI/死亡)发生在29例MetS患者和9例无MetS患者中(9.0% vs. 2.8%， P=0.001)。Kaplan-Meier分析显示，两组无事件生存率差异有统计学意义(P=0.005，图)。多因素分析(Cox回归)显示，入组时met预测AMI/死亡与年龄、性别或既往心血管疾病无关(校正优势比2.25,95% CI 1.06-4.75, P=0.034)。结论:MetS是FCH患者主要心血管事件的独立预测因子。
{"title":"Moderated Poster Session II: Prevention and health policy","authors":"J. Skoumas, K. Aznaouridis, VMetaxa, F. Platsouka, L. Papadimitriou, C. Pitsavos, C. Stefanadis, M. Lorgeril, P. Salen, F. Laporte, A. Castelnuovo, V. Krogh, M. Donati, A. Tverdal, F. Visseren, A. Algra","doi":"10.1177/17418267090160s103","DOIUrl":"https://doi.org/10.1177/17418267090160s103","url":null,"abstract":"M135 Metabolic syndrome is a predictor of outcome in patients with familial combined hyperlipidemia CMasoura, J Skoumas, K Aznaouridis, VMetaxa, F Platsouka, L Papadimitriou, C Pitsavos, C Stefanadis Athens, Greece Topic: Lipids and atherosclerosis Purpose: Familial combined hyperlipidemia (FCH) is a polygenic lipid disorder associated with premature cardiovascular disease. It is unknown whether metabolic syndrome (MetS) modulates cardiovascular risk in FCH patients. Methods: We studied prospectively 644 FCH patients (421 men) for 9.2 3.6 years. Demographic characteristics and biochemical parameters were evaluated at enrolment, before the initiation of treatment. The diagnosis of MetS was based on the modified ATP III criteria (glucose >100 mg/dl). Hard cardiovascular end-points, like acute myocardial infarction (AMI) and cardiovascular death, were recorded during the follow-up. Results: The 323 patients with MetS were older (50.8 10.2 vs. 46.7 11.0 years, öÀ<0.001) and had higher triglyceride and glucose levels, but they had lower HDL-C levels compared with patients without MetS (all öÀ<0.001). There was no difference in total cholesterol. The combined endpoint (AMI/death) occurred in 29 patients with MetS and in 9 patients without MetS (9.0% vs. 2.8%, P=0.001). Kaplan-Meier analysis showed a significant difference in the event-free survival between the 2 groups (P=0.005, figure). Multivariate analysis (Cox regression) showed that MetS at enrolment predicts AMI/death independent of age, sex or previous cardiovascular disease (adjusted odds ratio 2.25, 95% CI 1.06-4.75, P=0.034). Conclusions: MetS represents an independent predictor of major cardiovascular events in FCH patients.","PeriodicalId":50492,"journal":{"name":"European Journal of Cardiovascular Prevention & Rehabilitation","volume":"11 1","pages":"S26 - S28"},"PeriodicalIF":0.0,"publicationDate":"2009-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/17418267090160s103","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"65491031","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2009-05-01DOI: 10.1177/17418267090160s109
S. Dimopoulos, V. Anagnostakou, E. Chatzimichail, L. Karatzanos, K. Malliaras, N. Diakos, A. Tasoulis, S. Nanas, M. Bilińska, M. Kosydar-Piechna, A. Gąsiorowska, T. Mikulski, K. Nazar, R. Piotrowicz, G. Caminiti, M. Volterrani, A. Cerrito, R. Massaro, S. Bovone, M. Beato, A. Mancuso, M. Rosano, E. Roelleke, B. Zoller, M. Schneider, U. Wirtz, A. Radzewitz
O385 Randomised comparison of the effects of interval aerobic plus strength training versus interval aerobic training alone on endothelium function in chronic heart failure ST Dimopoulos, V Anagnostakou, E Chatzimichail, L Karatzanos, K Malliaras, N Diakos, A Tasoulis, S Nanas Cardiopulmonary Rehabilitation Centre, ‘Evgenidio’ Hospital, University of Athens, Greece, 3rd Clinic of Cardiology, ‘Alexandra’ Hospital, University of Athens, Greece Topic: Cardiovascular rehabilitation Purpose: Exercise training confers beneficial effects on endothelial function in patients with chronic heart failure (CHF). However the optimal form of training remains debated. This randomised study compared the effects of interval aerobic combined with strength training versus aerobic training alone on endothelial function in CHF patients. Methods: We studied 28 consecutive patients in optimally treated, stable CHF who were randomly assigned to 3 times weekly training sessions for 3 months, consisting of a) 40 min of aerobic interval training (30 sec effort 60 sec rest at intensity 100% VO2peak) (n=14), versus b) 20 min of similar aerobic, interval training plus 20 min of strength training of various muscle groups (quadriceps, hamstrings, muscles of the shoulder zone, biceps) (n=14). All patients underwent maximal, symptom-limited cardiopulmonary exercise testing and ultrasound evaluation of endothelial function by flow-mediated vasodilation (FMD) before and after the programme. Results: Peak oxygen uptake increased significantly and similarly in both groups, from 15.7 4.0 to 17.2 3.7 ml/kg/min in the aerobic training alone group (p=0.03), and from 15.7 6.0 to 18.3 6.3 ml/kg/min in the combined training group (p=0.006). A significant improvement in FMD (p=0.002) was observed in the combined training group, in contrast to the aerobic training alone group (p=ns); the improvement was significantly greater in the combined training than in the aerobic training alone group (p <0.05). Conclusions: A 3-month exercise-training programme improved endothelial function and physical performance in CHF patients. Combining high-intensity, interval aerobic exercise with strength training had a greater beneficial effect on endothelial function than interval, aerobic exercise alone.
O385:间歇有氧加力量训练与间歇有氧单独训练对慢性心力衰竭患者内皮功能的随机比较:ST Dimopoulos, V Anagnostakou, E Chatzimichail, L Karatzanos, K Malliaras, N Diakos, A Tasoulis, S Nanas心肺康复中心，希腊雅典大学Evgenidio医院，希腊雅典大学亚历山德拉医院心脏病学第三诊所，主题:心血管康复运动训练对慢性心力衰竭(CHF)患者的内皮功能有有益的影响。然而，最佳的训练形式仍然存在争议。这项随机研究比较了间歇有氧联合力量训练与单独有氧训练对心力衰竭患者内皮功能的影响。方法:我们研究了28例连续治疗的稳定CHF患者，他们被随机分配到每周3次训练，持续3个月，包括a) 40分钟的有氧间歇训练(30秒努力，60秒休息，强度100% VO2peak) (n=14)， b) 20分钟类似的有氧间歇训练加上20分钟不同肌肉群(股四头肌，腘绳肌，肩带肌肉，二头肌)的力量训练(n=14)。所有患者在项目前后均进行了最大限度、症状受限的心肺运动试验和超声血流介导的血管舒张(FMD)内皮功能评估。结果:两组的峰值摄氧量均有相似的显著增加，单有氧训练组从15.7 4.0 ml/kg/min增加到17.2 3.7 ml/kg/min (p=0.03)，联合训练组从15.7 6.0 ml/kg/min增加到18.3 6.3 ml/kg/min (p=0.006)。与单独有氧训练组相比，联合训练组FMD有显著改善(p=0.002);联合训练组的改善明显大于单独有氧训练组(p <0.05)。结论:3个月的运动训练计划改善了CHF患者的内皮功能和身体表现。高强度间歇有氧运动与力量训练相结合比单独间歇有氧运动对内皮功能有更大的有益作用。
{"title":"Oral Session II. Exercise training in coronary artery disease: what is good for whom","authors":"S. Dimopoulos, V. Anagnostakou, E. Chatzimichail, L. Karatzanos, K. Malliaras, N. Diakos, A. Tasoulis, S. Nanas, M. Bilińska, M. Kosydar-Piechna, A. Gąsiorowska, T. Mikulski, K. Nazar, R. Piotrowicz, G. Caminiti, M. Volterrani, A. Cerrito, R. Massaro, S. Bovone, M. Beato, A. Mancuso, M. Rosano, E. Roelleke, B. Zoller, M. Schneider, U. Wirtz, A. Radzewitz","doi":"10.1177/17418267090160s109","DOIUrl":"https://doi.org/10.1177/17418267090160s109","url":null,"abstract":"O385 Randomised comparison of the effects of interval aerobic plus strength training versus interval aerobic training alone on endothelium function in chronic heart failure ST Dimopoulos, V Anagnostakou, E Chatzimichail, L Karatzanos, K Malliaras, N Diakos, A Tasoulis, S Nanas Cardiopulmonary Rehabilitation Centre, ‘Evgenidio’ Hospital, University of Athens, Greece, 3rd Clinic of Cardiology, ‘Alexandra’ Hospital, University of Athens, Greece Topic: Cardiovascular rehabilitation Purpose: Exercise training confers beneficial effects on endothelial function in patients with chronic heart failure (CHF). However the optimal form of training remains debated. This randomised study compared the effects of interval aerobic combined with strength training versus aerobic training alone on endothelial function in CHF patients. Methods: We studied 28 consecutive patients in optimally treated, stable CHF who were randomly assigned to 3 times weekly training sessions for 3 months, consisting of a) 40 min of aerobic interval training (30 sec effort 60 sec rest at intensity 100% VO2peak) (n=14), versus b) 20 min of similar aerobic, interval training plus 20 min of strength training of various muscle groups (quadriceps, hamstrings, muscles of the shoulder zone, biceps) (n=14). All patients underwent maximal, symptom-limited cardiopulmonary exercise testing and ultrasound evaluation of endothelial function by flow-mediated vasodilation (FMD) before and after the programme. Results: Peak oxygen uptake increased significantly and similarly in both groups, from 15.7 4.0 to 17.2 3.7 ml/kg/min in the aerobic training alone group (p=0.03), and from 15.7 6.0 to 18.3 6.3 ml/kg/min in the combined training group (p=0.006). A significant improvement in FMD (p=0.002) was observed in the combined training group, in contrast to the aerobic training alone group (p=ns); the improvement was significantly greater in the combined training than in the aerobic training alone group (p <0.05). Conclusions: A 3-month exercise-training programme improved endothelial function and physical performance in CHF patients. Combining high-intensity, interval aerobic exercise with strength training had a greater beneficial effect on endothelial function than interval, aerobic exercise alone.","PeriodicalId":50492,"journal":{"name":"European Journal of Cardiovascular Prevention & Rehabilitation","volume":"16 1","pages":"S82 - S83"},"PeriodicalIF":0.0,"publicationDate":"2009-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/17418267090160s109","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"65491215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2009-05-01DOI: 10.1177/17418267090160s110
{"title":"Oral Session III. Is now the time for universal preparticipation screening?","authors":"","doi":"10.1177/17418267090160s110","DOIUrl":"https://doi.org/10.1177/17418267090160s110","url":null,"abstract":"","PeriodicalId":50492,"journal":{"name":"European Journal of Cardiovascular Prevention & Rehabilitation","volume":"16 1","pages":"S84 - S85"},"PeriodicalIF":0.0,"publicationDate":"2009-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/17418267090160s110","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"65491228","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2009-05-01DOI: 10.1177/17418267090160s106
D. Niederseer, A. Egger, J. Niebauer, Z. Pagava, G. Saatashvili, D. Trapaidze, B. Tsinamdzgvrishvili, R. Agladze, C. Beller, K. Deyerling, G. Tenderich, D. Horstkotte, R. Koerfer, K. Mellwig, F. Trujillo, J. Fernández-Armenta, C. Fernández‐Vivancos, V. Pedrosa, B. Prado, M. Borbolla, A. Castro, J. Cruz
M280 Cardiovascular events during FIFA Soccer World Cup 2006 D Niederseer, A Egger, J Niebauer Paracelsus Medical University, Salzburg, Austria Topic: Sports cardiology Objectives: Recently, an increase in the incidence of cardiovascular events in Bavaria during FIFA Soccer World Cup 2006 (WC) has been reported. A significant pooling of cardiovascular events on days the German team played as well as on the day of the final game was shown. However, in this excellent report only a limited number of cardiac diagnoses were analysed. Methods: In order to assess further acute cardiac disorders we requested data for the period of the WC (June 9-July 9, 2006) but also for control periods (May 1-July 31, 2003 and 2005; May 1June 8, 2006 i.e. before WC and July 10-31, 2006 i.e. after WC) from the Bavarian Council for Statistics and Data Management on diagnoses. The following diagnoses were assessed: myocardial infarction (ICD-10; I 21); cardiac arrest (I 46); paroxysmal tachycardia (I 47); atrial fibrillation, atrial flutter (I 48); all remaining tachyarrhythmias (I 49). Results: Despite an increase in cardiac events among Bavarians on the days the German team played, there was no overall increase during the WC or respective control periods (Table 1). Conclusion: Whereas the original analysis by Wilbert-Lampen et al. urges organisers of largescale events to be especially prepared on days on which local teams play, our data somewhat assure us that watching such enjoyable events does not lead to an overall increase in cardiac events beyond that seen during control periods. We rather hypothesise that emotional stress induced by watching soccer pools cardiovascular events to one specific moment i.e. a soccer game, but would have likely occurred anyway within the control period and thus within the very near future.
D Niederseer, A Egger, J Niebauer Paracelsus医科大学，萨尔茨堡，题目:运动心脏病学目的:最近，据报道，2006年世界杯(WC)期间巴伐利亚州心血管事件的发生率有所增加。研究显示，在德国队比赛当天和决赛当天，心血管事件的发生率显著增加。然而，在这篇优秀的报告中，只分析了有限数量的心脏诊断。方法:为了进一步评估急性心脏疾病，我们收集了世界卫生大会期间(2006年6月9日至7月9日)以及对照期(2003年5月1日至7月31日)的数据;巴伐利亚统计和数据管理委员会关于诊断的报告(2006年5月1日至6月8日，即WC之前，2006年7月10日至31日，即WC之后)。评估以下诊断:心肌梗死(ICD-10);我21);心脏骤停(I 46);阵发性心动过速(I 47);心房颤动，心房扑动(I 48);所有剩余的心动过速(I 49)。结果:尽管在德国队比赛的日子里，巴伐利亚人的心脏事件有所增加，但在世界杯期间或各自的控制期间，总体上没有增加(表1)。尽管Wilbert-Lampen等人的原始分析敦促大型赛事的组织者在当地球队比赛的日子里特别做好准备，但我们的数据在一定程度上向我们保证，观看这种令人愉快的赛事并不会导致心脏事件的总体增加，而不是在控制期间看到的。我们更愿意假设，观看足球引起的情绪压力将心血管事件推到一个特定的时刻，比如一场足球比赛，但无论如何都可能在控制期内发生，因此在不久的将来发生。
{"title":"Moderated Poster Session IV: Sport cardiology","authors":"D. Niederseer, A. Egger, J. Niebauer, Z. Pagava, G. Saatashvili, D. Trapaidze, B. Tsinamdzgvrishvili, R. Agladze, C. Beller, K. Deyerling, G. Tenderich, D. Horstkotte, R. Koerfer, K. Mellwig, F. Trujillo, J. Fernández-Armenta, C. Fernández‐Vivancos, V. Pedrosa, B. Prado, M. Borbolla, A. Castro, J. Cruz","doi":"10.1177/17418267090160s106","DOIUrl":"https://doi.org/10.1177/17418267090160s106","url":null,"abstract":"M280 Cardiovascular events during FIFA Soccer World Cup 2006 D Niederseer, A Egger, J Niebauer Paracelsus Medical University, Salzburg, Austria Topic: Sports cardiology Objectives: Recently, an increase in the incidence of cardiovascular events in Bavaria during FIFA Soccer World Cup 2006 (WC) has been reported. A significant pooling of cardiovascular events on days the German team played as well as on the day of the final game was shown. However, in this excellent report only a limited number of cardiac diagnoses were analysed. Methods: In order to assess further acute cardiac disorders we requested data for the period of the WC (June 9-July 9, 2006) but also for control periods (May 1-July 31, 2003 and 2005; May 1June 8, 2006 i.e. before WC and July 10-31, 2006 i.e. after WC) from the Bavarian Council for Statistics and Data Management on diagnoses. The following diagnoses were assessed: myocardial infarction (ICD-10; I 21); cardiac arrest (I 46); paroxysmal tachycardia (I 47); atrial fibrillation, atrial flutter (I 48); all remaining tachyarrhythmias (I 49). Results: Despite an increase in cardiac events among Bavarians on the days the German team played, there was no overall increase during the WC or respective control periods (Table 1). Conclusion: Whereas the original analysis by Wilbert-Lampen et al. urges organisers of largescale events to be especially prepared on days on which local teams play, our data somewhat assure us that watching such enjoyable events does not lead to an overall increase in cardiac events beyond that seen during control periods. We rather hypothesise that emotional stress induced by watching soccer pools cardiovascular events to one specific moment i.e. a soccer game, but would have likely occurred anyway within the control period and thus within the very near future.","PeriodicalId":50492,"journal":{"name":"European Journal of Cardiovascular Prevention & Rehabilitation","volume":"16 1","pages":"S54 - S56"},"PeriodicalIF":0.0,"publicationDate":"2009-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/17418267090160s106","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"65491110","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2009-05-01DOI: 10.1177/17418267090160s112
M. Sandri, S. Gielen, V. Adams, N. Mangner, R. Hoellriegel, S. Erbs, A. Linke, G. Schuler, L. Bruyndonckx, C. V. Berckelaer, G. Frederix, P. Beckers, C. Vrints, V. Conraads, V. Vargová, M. Pytliak, V. Mechírová, T. Thomaes
M418 Age related alterations of endothelial function in patients with chronic heart failure and healthy subjects Effects of exercise training M Sandri, S Gielen, V Adams, N Mangner, R Hoellriegel, S Erbs, A Linke, G Schuler University of Leipzig Heart Centre, Leipzig, Germany Topic: Exercise physiology, testing and training Background: Impairment of endothelial function may occur in both physiologic aging and chronic heart failure (CHF). It has, however, never been assessed, whether the degree of endothelial dysfunction in CHF patients is influenced by age and if the well established beneficial effects of endurance exercise training on endothelial function are diminished in old age. Methods: In this study we randomised 50 pts. with stable CHF (age 61.4 2.7 years, EF 26.3 1.5%, VO2max 13.8 2.3ml/kg*min) and 50 healthy subjects (HS) (age 59.8 3.1 years, EF 60 1%, VO2max 21.1 3.1 ml/kg*min) to a training (T) or a control group (C). To detect possible aging effects we included subjects below 55 (young) and above 65 years (old). Subjects in the T-group exercised 4 times daily at 60 to 70% of VO2max for 4 weeks under supervision. At baseline and after the intervention, flow-mediated dilatation (FMD) was assessed by a highresolution radial ultrasound (NIUS2). Results: As compared to young HS, old HS showed at baseline a reduced FMD (young: 16.7 1.1%; old: 12.1 1.6%; p<0.05). In CHF patients, endothelial function was impaired (young 9.3 0.9%; old: 9.1 1.2%). No difference of these baseline parameters between the age groups was observed (p=0.72) in this subgroup. As a result of ET, FMD improved from 12.2 0.9% to 15.9 1.2% in old HS (p<0.05), while it remained unchanged in young training HS and C respectively. In young and old patients with CHF four weeks of ET resulted in a significant change in FMD (young: from 9.2 0.8 to 13.1 1.2; p<0.05; old: from 9.0 1.1 to 12.4 1.0 p<0.05). In C no effect was detectable. Conclusions: The present trial provides new insight into the age-dependency of cardiovascular training effects: Among HS aging is associated with the development of endothelial dysfunction. In CHF both young and old patients exhibit a similar degree of endothelial dysfunction. Four weeks of ET are effective in improving endothelial dysfunction in old HS and in all age groups of CHF patients. The training effect was not significantly diminished among older patients with underlining the potentials of rehabilitation interventions in this patient group, where CHF is most prevalent.
M Sandri, S Gielen, V Adams, N manner, R Hoellriegel, S Erbs, A Linke, G Schuler University of Leipzig心脏中心，德国题目:运动生理学，测试和训练背景:内皮功能损伤可能发生在生理性衰老和慢性心力衰竭(CHF)中。然而，CHF患者的内皮功能障碍程度是否受年龄的影响，以及耐力训练对内皮功能的有益作用是否在老年时减弱，这一点从未被评估过。方法:在这项研究中，我们随机选取了50例患者。稳定CHF(年龄61.4 - 2.7岁，EF 26.3 1.5%， VO2max 13.8 - 2.3ml/kg*min)和50名健康受试者(HS)(年龄59.8 - 3.1岁，EF 601%， VO2max 21.1 - 3.1 ml/kg*min)分为训练组(T)和对照组(C)。为了检测可能的衰老影响，我们将55岁以下(年轻)和65岁以上(老年)的受试者纳入其中。t组受试者在监督下每天运动4次，以最大摄氧量的60 - 70%运动4周。在基线和干预后，通过高分辨率径向超声(NIUS2)评估血流介导扩张(FMD)。结果:与年轻HS相比，老年HS在基线时FMD降低(年轻:16.7 1.1%;老年:12.1.6%;p < 0.05)。在CHF患者中，内皮功能受损(年轻9.3 0.9%;老年:9.1 1.2%)。在这个亚组中，这些基线参数在年龄组之间没有差异(p=0.72)。ET的作用使老HS的FMD由12.2 0.9%提高到15.9 1.2% (p<0.05)，而年轻HS和C的FMD则保持不变。在年轻和老年CHF患者中，四周的ET导致FMD的显著变化(年轻:从9.2 0.8到13.1 1.2;p < 0.05;年龄:9.0 1.1 ~ 12.4 1.0 p<0.05)。在C中没有检测到影响。结论:本试验为心血管训练效应的年龄依赖性提供了新的见解:在HS中，衰老与内皮功能障碍的发生有关。在慢性心力衰竭中，年轻和老年患者都表现出相似程度的内皮功能障碍。4周的ET治疗可有效改善老年HS患者和所有年龄组的CHF患者的内皮功能障碍。训练效果在老年患者中没有明显减弱，这表明在该患者组中，康复干预的潜力是最普遍的。
{"title":"Moderated Poster Session V. Basic science","authors":"M. Sandri, S. Gielen, V. Adams, N. Mangner, R. Hoellriegel, S. Erbs, A. Linke, G. Schuler, L. Bruyndonckx, C. V. Berckelaer, G. Frederix, P. Beckers, C. Vrints, V. Conraads, V. Vargová, M. Pytliak, V. Mechírová, T. Thomaes","doi":"10.1177/17418267090160s112","DOIUrl":"https://doi.org/10.1177/17418267090160s112","url":null,"abstract":"M418 Age related alterations of endothelial function in patients with chronic heart failure and healthy subjects Effects of exercise training M Sandri, S Gielen, V Adams, N Mangner, R Hoellriegel, S Erbs, A Linke, G Schuler University of Leipzig Heart Centre, Leipzig, Germany Topic: Exercise physiology, testing and training Background: Impairment of endothelial function may occur in both physiologic aging and chronic heart failure (CHF). It has, however, never been assessed, whether the degree of endothelial dysfunction in CHF patients is influenced by age and if the well established beneficial effects of endurance exercise training on endothelial function are diminished in old age. Methods: In this study we randomised 50 pts. with stable CHF (age 61.4 2.7 years, EF 26.3 1.5%, VO2max 13.8 2.3ml/kg*min) and 50 healthy subjects (HS) (age 59.8 3.1 years, EF 60 1%, VO2max 21.1 3.1 ml/kg*min) to a training (T) or a control group (C). To detect possible aging effects we included subjects below 55 (young) and above 65 years (old). Subjects in the T-group exercised 4 times daily at 60 to 70% of VO2max for 4 weeks under supervision. At baseline and after the intervention, flow-mediated dilatation (FMD) was assessed by a highresolution radial ultrasound (NIUS2). Results: As compared to young HS, old HS showed at baseline a reduced FMD (young: 16.7 1.1%; old: 12.1 1.6%; p<0.05). In CHF patients, endothelial function was impaired (young 9.3 0.9%; old: 9.1 1.2%). No difference of these baseline parameters between the age groups was observed (p=0.72) in this subgroup. As a result of ET, FMD improved from 12.2 0.9% to 15.9 1.2% in old HS (p<0.05), while it remained unchanged in young training HS and C respectively. In young and old patients with CHF four weeks of ET resulted in a significant change in FMD (young: from 9.2 0.8 to 13.1 1.2; p<0.05; old: from 9.0 1.1 to 12.4 1.0 p<0.05). In C no effect was detectable. Conclusions: The present trial provides new insight into the age-dependency of cardiovascular training effects: Among HS aging is associated with the development of endothelial dysfunction. In CHF both young and old patients exhibit a similar degree of endothelial dysfunction. Four weeks of ET are effective in improving endothelial dysfunction in old HS and in all age groups of CHF patients. The training effect was not significantly diminished among older patients with underlining the potentials of rehabilitation interventions in this patient group, where CHF is most prevalent.","PeriodicalId":50492,"journal":{"name":"European Journal of Cardiovascular Prevention & Rehabilitation","volume":"16 1","pages":"S88 - S90"},"PeriodicalIF":0.0,"publicationDate":"2009-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/17418267090160s112","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"65490814","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2009-05-01DOI: 10.1177/17418267090160s105
G. Silva, O. Sousa, N. Ferreira, N. Bettencourt, F. Miranda, M. Teixeira, V. Ribeiro, F. Cacciatore, F. Mazzella, D. Acanfora, G. Longobardi, A. Nicolino, L. Odierna, G. Furgi, F. Rengo, D. Bacquer, F. Kittel, M. Kornitzer, G. Backer, S. Dimopoulos, G. Tzanis, V. Agapitou, H. Pozios, A. Bouchla, E. Zerva
M270 Can a short cardiac rehabilitation programme influence novel markers of cardiovascular risk evaluated by computed tomography imaging? Preliminary results of a randomised clinical study R P Lima, G Silva, O Sousa, N Dias Ferreira, N Bettencourt, F Miranda, M Teixeira, V Gama Ribeiro Gaia, Portugal Topic: Cardiovascular rehabilitation Purpose: To evaluate the impact of a short course (8 weeks), moderate intensity cardiac rehabilitation programme (CRP) on markers of systemic inflammation and cardiovascular risk (total adipose tissue (TAP), subcutaneous adipose tissue (SAT), visceral adipose tissue (VAT) at abdominal level) by computed tomography imaging (CT-scan) in postinfarction patients. Methods: Fifty-four postinfarction patients were randomised into two groups: group R composed of 31 patients (27 males; mean age 53.9 years 11.4; mean LV ejection fraction (EF) 54.2% 8.9%) entered a 8 weeks CRP, whereas group NR, composed of 23 patients (18 males; mean age 57.7 years; mean EF 49.8% 10.8%) did not enter any CRP being only followed in an outpatient basis. CT-scan was performed before and after the programme and the evolution of the different parameters of CT-scan in the two groups was analysed. Results: After the CRP, group R patients did not show any significant improvement in total adipose tissue when compared with group NR patients (4 TAT -12.8 43.7 vs -11.34 47.57 respectively; p = 0.9). Equally, there were no significant differences between the groups on subcutaneous adipose tissue (4 SAT -3.85 in group R vs -10.5 in group NR; p = 0.79). Visceral adipose tissue has decreased in group R (-8.94) while has increased in group NR (+2.31), but this difference was not statistically significant (p=0.64). Conclusions: In our population an 8 week CRP did not significantly affect the adipose tissue. However, at 3-month, we can observe a slight trend toward reduction in visceral adipose tissue. The limited duration of the programme and the "low" exercise loads applied may have accounted for these results. More intense and prolonged comprehensive CR programmes are probably needed to obtain an impact, mainly in the visceral adipose tissue.
M270短期心脏康复计划能影响计算机断层成像评估心血管风险的新标志物吗?随机临床研究R P Lima, G Silva, O Sousa, N Dias Ferreira, N Bettencourt, F Miranda, M Teixeira, V Gama Ribeiro Gaia，葡萄牙通过计算机断层成像(ct扫描)评估短疗程(8周)、中等强度心脏康复计划(CRP)对梗死后患者全身炎症和心血管风险标志物(总脂肪组织(TAP)、皮下脂肪组织(SAT)、腹部内脏脂肪组织(VAT))的影响。方法:54例梗死后患者随机分为两组:R组31例，其中男性27例;平均年龄53.9岁，11.4岁;平均左室射血分数(EF) 54.2% 8.9%)进入8周CRP，而NR组由23例患者组成(18例男性;平均年龄57.7岁;平均EF为49.8%(10.8%)，未输入任何CRP，仅在门诊进行随访。在节目前后进行ct扫描，分析两组ct扫描不同参数的演变。结果:CRP治疗后，R组患者总脂肪组织较NR组患者无明显改善(4 TAT分别为-12.8 43.7 vs -11.34 47.57;P = 0.9)。同样，各组间皮下脂肪组织也无显著差异(R组4 SAT -3.85 vs NR组-10.5;P = 0.79)。R组内脏脂肪组织减少(-8.94)，NR组增加(+2.31)，但差异无统计学意义(p=0.64)。结论:在我们的人群中，8周的CRP对脂肪组织没有显著影响。然而，在3个月时，我们可以观察到内脏脂肪组织有轻微减少的趋势。该计划持续时间有限和所施加的“低”运动负荷可能是造成这些结果的原因。可能需要更大强度和更长时间的全面CR计划来获得影响，主要是在内脏脂肪组织中。
{"title":"Moderated Poster Session III: Cardiac rehabilitation","authors":"G. Silva, O. Sousa, N. Ferreira, N. Bettencourt, F. Miranda, M. Teixeira, V. Ribeiro, F. Cacciatore, F. Mazzella, D. Acanfora, G. Longobardi, A. Nicolino, L. Odierna, G. Furgi, F. Rengo, D. Bacquer, F. Kittel, M. Kornitzer, G. Backer, S. Dimopoulos, G. Tzanis, V. Agapitou, H. Pozios, A. Bouchla, E. Zerva","doi":"10.1177/17418267090160s105","DOIUrl":"https://doi.org/10.1177/17418267090160s105","url":null,"abstract":"M270 Can a short cardiac rehabilitation programme influence novel markers of cardiovascular risk evaluated by computed tomography imaging? Preliminary results of a randomised clinical study R P Lima, G Silva, O Sousa, N Dias Ferreira, N Bettencourt, F Miranda, M Teixeira, V Gama Ribeiro Gaia, Portugal Topic: Cardiovascular rehabilitation Purpose: To evaluate the impact of a short course (8 weeks), moderate intensity cardiac rehabilitation programme (CRP) on markers of systemic inflammation and cardiovascular risk (total adipose tissue (TAP), subcutaneous adipose tissue (SAT), visceral adipose tissue (VAT) at abdominal level) by computed tomography imaging (CT-scan) in postinfarction patients. Methods: Fifty-four postinfarction patients were randomised into two groups: group R composed of 31 patients (27 males; mean age 53.9 years 11.4; mean LV ejection fraction (EF) 54.2% 8.9%) entered a 8 weeks CRP, whereas group NR, composed of 23 patients (18 males; mean age 57.7 years; mean EF 49.8% 10.8%) did not enter any CRP being only followed in an outpatient basis. CT-scan was performed before and after the programme and the evolution of the different parameters of CT-scan in the two groups was analysed. Results: After the CRP, group R patients did not show any significant improvement in total adipose tissue when compared with group NR patients (4 TAT -12.8 43.7 vs -11.34 47.57 respectively; p = 0.9). Equally, there were no significant differences between the groups on subcutaneous adipose tissue (4 SAT -3.85 in group R vs -10.5 in group NR; p = 0.79). Visceral adipose tissue has decreased in group R (-8.94) while has increased in group NR (+2.31), but this difference was not statistically significant (p=0.64). Conclusions: In our population an 8 week CRP did not significantly affect the adipose tissue. However, at 3-month, we can observe a slight trend toward reduction in visceral adipose tissue. The limited duration of the programme and the \"low\" exercise loads applied may have accounted for these results. More intense and prolonged comprehensive CR programmes are probably needed to obtain an impact, mainly in the visceral adipose tissue.","PeriodicalId":50492,"journal":{"name":"European Journal of Cardiovascular Prevention & Rehabilitation","volume":"16 1","pages":"S51 - S53"},"PeriodicalIF":0.0,"publicationDate":"2009-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/17418267090160s105","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"65491101","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2009-05-01DOI: 10.1177/17418267090160s114
A. Jurko, I. Tonhajzerova, Z. Havlicekova, P. Wandell, M. Hellénius, M. Markus, J. Stritzke, W. Lieb, A. Luchner, A. Doering, U. Keil, H. Hense, H. Schunkert, H. Neuhauser, U. Ellert, M. Thamm, A. S. Rosario
P438 Systolic blood pressure amplification. The Czech post-MONICA study P Wohlfahrt, D Palous, M Ingrischova, R Cifkova IKEM, Prague, Czech Republic, VFN, Prague, Czech Republic Topic: Hypertension Background: Central (cSBP) and brachial (bSBP) systolic blood pressures usually differ substantially. Recent studies have shown cSBP to be a better cardiovascular risk predictor than bSBP. On the other hand, brachial blood pressure measurement is more readily accessible in clinical practice. The aim of our study was to identify factors affecting the difference between cSBP and bSBP expressed as systolic blood pressure amplification [(bSBP-cSBP)/bSBP]. Methods: A subgroup of 299 patients aged 47.7 11.2 years (52% of men) from the Czech postMONICA study dealing with a randomly selected representative population sample were examined. After 10 minutes of rest in the recumbent position, peripheral blood pressure measurement and central blood pressure approximation were performed using an Omron HEM 9000 AI. Results: Systolicbloodpressureamplificationcorrelatedwithage(r=-0.47,p<0.001),height(r=0.47, p<0.001), weight (r= 0.22, p<0.001), mean arterial blood pressure (r= -0.23, p<0.001), heart rate (r= 0.127, p<0.05), triglyceride logarithm (r= -0.13, p<0.05), total (r= -0.165, p<0.01) and LDLcholesterol (r= -0.15, p<0.01), arterial hypertension (r= -0.22, p<0.001), and smoking status expressed as cigarette-years (r= -0.28, p<0.05). In multiple stepwise regression analysis, only age, height, heart rate, mean arterial blood pressure, waist-to-hip ratio, triglyceride logarithm, and arterial hypertension remained to be associated significantly with systolic blood pressure amplification. Conclusion: Our results suggest that the difference between central and brachial systolic blood pressure is affected by age and cardiovascular risk factors. This is probably due to large vessel stiffening by atherosclerosis.
P438收缩压放大。P Wohlfahrt, D Palous, M Ingrischova, R Cifkova IKEM，布拉格，捷克共和国，VFN，布拉格，捷克共和国主题:高血压背景:中央(cSBP)和肱(bSBP)收缩压通常差异很大。最近的研究表明，cSBP是比bSBP更好的心血管风险预测指标。另一方面，臂膀血压测量在临床实践中更容易获得。本研究的目的是确定影响收缩压扩增[(bSBP-cSBP)/bSBP]表达的cSBP和bSBP差异的因素。方法:对捷克postMONICA研究中299例年龄47.7 - 11.2岁的患者(52%为男性)进行亚组研究，随机选择代表性人群样本。平卧休息10分钟后，使用欧姆龙HEM 9000 AI测量外周血压和中心血压近似。结果:收缩压放大与年龄(r=-0.47,p<0.001)、身高(r=0.47, p<0.001)、体重(r= 0.22, p<0.001)、平均动脉血压(r= -0.23, p<0.001)、心率(r= 0.127, p<0.05)、甘油三酯对数(r= -0.13, p<0.05)、总血压(r= -0.165, p<0.01)、低密度脂蛋白胆固醇(r= -0.15, p<0.01)、动脉高血压(r= -0.22, p<0.001)、吸烟状况(r= -0.28, p<0.05)相关。在多元逐步回归分析中，只有年龄、身高、心率、平均动脉血压、腰臀比、甘油三酯对数和动脉高血压与收缩压放大存在显著相关。结论:中央收缩压和肱收缩压的差异受年龄和心血管危险因素的影响。这可能是由于动脉粥样硬化引起的大血管硬化。
{"title":"Poster Session IV","authors":"A. Jurko, I. Tonhajzerova, Z. Havlicekova, P. Wandell, M. Hellénius, M. Markus, J. Stritzke, W. Lieb, A. Luchner, A. Doering, U. Keil, H. Hense, H. Schunkert, H. Neuhauser, U. Ellert, M. Thamm, A. S. Rosario","doi":"10.1177/17418267090160s114","DOIUrl":"https://doi.org/10.1177/17418267090160s114","url":null,"abstract":"P438 Systolic blood pressure amplification. The Czech post-MONICA study P Wohlfahrt, D Palous, M Ingrischova, R Cifkova IKEM, Prague, Czech Republic, VFN, Prague, Czech Republic Topic: Hypertension Background: Central (cSBP) and brachial (bSBP) systolic blood pressures usually differ substantially. Recent studies have shown cSBP to be a better cardiovascular risk predictor than bSBP. On the other hand, brachial blood pressure measurement is more readily accessible in clinical practice. The aim of our study was to identify factors affecting the difference between cSBP and bSBP expressed as systolic blood pressure amplification [(bSBP-cSBP)/bSBP]. Methods: A subgroup of 299 patients aged 47.7 11.2 years (52% of men) from the Czech postMONICA study dealing with a randomly selected representative population sample were examined. After 10 minutes of rest in the recumbent position, peripheral blood pressure measurement and central blood pressure approximation were performed using an Omron HEM 9000 AI. Results: Systolicbloodpressureamplificationcorrelatedwithage(r=-0.47,p<0.001),height(r=0.47, p<0.001), weight (r= 0.22, p<0.001), mean arterial blood pressure (r= -0.23, p<0.001), heart rate (r= 0.127, p<0.05), triglyceride logarithm (r= -0.13, p<0.05), total (r= -0.165, p<0.01) and LDLcholesterol (r= -0.15, p<0.01), arterial hypertension (r= -0.22, p<0.001), and smoking status expressed as cigarette-years (r= -0.28, p<0.05). In multiple stepwise regression analysis, only age, height, heart rate, mean arterial blood pressure, waist-to-hip ratio, triglyceride logarithm, and arterial hypertension remained to be associated significantly with systolic blood pressure amplification. Conclusion: Our results suggest that the difference between central and brachial systolic blood pressure is affected by age and cardiovascular risk factors. This is probably due to large vessel stiffening by atherosclerosis.","PeriodicalId":50492,"journal":{"name":"European Journal of Cardiovascular Prevention & Rehabilitation","volume":"16 1","pages":"S116 - S94"},"PeriodicalIF":0.0,"publicationDate":"2009-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/17418267090160s114","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"65490924","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2009-05-01DOI: 10.1177/17418267090160s101
K. Bennett, I. Perry, H. Mcgee, K. Morgan, E. Shelley, S. Jennings, S. Capewell, P. Whincup, S. Wannamethee, O. Papacosta, A. Thomson, L. Lennon, R. Morris, V. Regecová, E. Kellerová, EC Cizmarova, A. Jurko, EO Ondriskova, U. Keil, D. Bacquer, G. Ambrosio, Ž. Reiner, D. Gaita
M12 Explaining the continuing decrease in CHD mortality in Ireland: comparing population health behaviour and health service contributions from 1985-2000 with 2000-2006 K Bennett, I Perry, H Mcgee, K Morgan, E Shelley, S Jennings, S Capewell St James Hospital, Dublin, Ireland, University College Cork, Cork, Ireland, Royal College Surgeons of Ireland, Dublin, Ireland, HSE, Dublin, Ireland, University of Liverpool, Liverpool, United Kingdom Topic: Cardiovascular epidemiology Mortality from cardiovascular disease has been falling in several countries with previously high rates. Irish CHD mortality rates fell dramatically from 1985 to 2000. Between 2000 and 2006 there was a further 45% decrease in CHD mortality rates amongst both men and women aged 2584 years (44% men; 46% women) in Ireland, i.e. 2315 fewer deaths than expected or ‘deaths prevented or postponed (DPPs)’ between 2000 and 2006. Objective: the aim of this study was to use the validated IMPACT CHD mortality model to examine the CHD mortality fall in Ireland between 2000 and 2006; to determine the contribution of risk factor changes and "evidence based" treatments to this decline; and to compare with similar analyses for 1985-2000. Methods: the cell-based IMPACT CHD mortality model in Microsoft Excel has been described in detail elsewhere. Data on risk factors was obtained from the SLû N 1998, 2002 and 2007 health and lifestyle surveys. Medical treatment data was available from the national prescribing databases, the Heartwatch programme for secondary prevention therapy in primary care, as well as the EUROASPIRE II and III (2001) and EUROHeart Failure I and II surveys. Results: approximately half of the decrease in CHD deaths between 2000 and 2006 were attributed to improvements in uptake of treatments (48%), particularly secondary prevention (15%), and treatments for chronic angina (11%) and for heart failure in the community and hospital (12%). For risk factors, the largest contribution came from reductions in population cholesterol (25%). Reduction in smoking contributed a disappointing 6% (compared with 26% in 1985-2000 comparisons); reflecting little progress in smoking cessation since 2000. There was little evidence of an improvement in population blood pressure reduction, or physical activity levels. There was further deterioration in the rates of diabetes and obesity since 2000, which is contributing to increased deaths from CHD. Conclusion: the substantial decrease in CHD mortality in Ireland continues in both men and women. Important contributors include reductions in total cholesterol levels in the population, a slight reduction in smoking prevalence, and increased medical and surgical interventions. Despite these positive changes, the continued increase in levels of obesity and diabetes could result in the adverse trends recently observed in other countries such as the UK, US and Australia, with a reversal of the mortality decline, particularly among the youngest groups.
M12解释爱尔兰冠心病死亡率的持续下降:比较1985-2000年与2000-2006年人口健康行为和卫生服务的贡献:K Bennett, I Perry, H Mcgee, K Morgan, E Shelley, S Jennings, S Capewell圣詹姆斯医院，爱尔兰都柏林，科克大学，爱尔兰科克，爱尔兰都柏林，爱尔兰皇家外科学院，爱尔兰都柏林，HSE，爱尔兰都柏林，利物浦大学，英国心血管流行病学心血管疾病死亡率在一些以前发病率很高的国家已经下降。从1985年到2000年，爱尔兰冠心病死亡率急剧下降。2000年至2006年期间，2584岁男女冠心病死亡率进一步下降45%(男性44%;在2000年至2006年期间，爱尔兰(46%妇女)的死亡人数比预期的少2315人，或"预防或推迟死亡"。目的:本研究的目的是使用经过验证的IMPACT冠心病死亡率模型来检查爱尔兰2000年至2006年间冠心病死亡率的下降;确定风险因素变化和“循证”治疗对这一下降的贡献;并与1985-2000年的类似分析进行比较。方法:microsoftexcel中基于细胞的IMPACT冠心病死亡率模型已在其他地方详细描述。关于风险因素的数据来自1998年、2002年和2007年的SLû健康和生活方式调查。医疗数据可从国家处方数据库、初级保健二级预防治疗心脏观察方案、EUROASPIRE II和III(2001年)以及欧洲心力衰竭I和II调查中获得。结果:2000年至2006年期间，冠心病死亡人数减少的大约一半归因于治疗的改善(48%)，特别是二级预防(15%)，慢性心绞痛治疗(11%)和社区和医院心力衰竭治疗(12%)。对于风险因素，最大的贡献来自于人群胆固醇的降低(25%)。吸烟减少的贡献仅为令人失望的6%(与1985-2000年的26%相比);反映自2000年以来在戒烟方面进展甚微。几乎没有证据表明在人口血压降低或身体活动水平方面有所改善。自2000年以来，糖尿病和肥胖症的发病率进一步恶化，这导致冠心病死亡人数增加。结论:爱尔兰男性和女性冠心病死亡率持续大幅下降。重要的贡献包括人口中总胆固醇水平的降低、吸烟率的轻微下降以及医疗和外科干预措施的增加。尽管有这些积极的变化，但肥胖和糖尿病水平的持续增加可能导致最近在英国、美国和澳大利亚等其他国家观察到的不利趋势，即死亡率下降的趋势出现逆转，特别是在最年轻的群体中。
{"title":"Moderated Poster Session I Epidemiology","authors":"K. Bennett, I. Perry, H. Mcgee, K. Morgan, E. Shelley, S. Jennings, S. Capewell, P. Whincup, S. Wannamethee, O. Papacosta, A. Thomson, L. Lennon, R. Morris, V. Regecová, E. Kellerová, EC Cizmarova, A. Jurko, EO Ondriskova, U. Keil, D. Bacquer, G. Ambrosio, Ž. Reiner, D. Gaita","doi":"10.1177/17418267090160s101","DOIUrl":"https://doi.org/10.1177/17418267090160s101","url":null,"abstract":"M12 Explaining the continuing decrease in CHD mortality in Ireland: comparing population health behaviour and health service contributions from 1985-2000 with 2000-2006 K Bennett, I Perry, H Mcgee, K Morgan, E Shelley, S Jennings, S Capewell St James Hospital, Dublin, Ireland, University College Cork, Cork, Ireland, Royal College Surgeons of Ireland, Dublin, Ireland, HSE, Dublin, Ireland, University of Liverpool, Liverpool, United Kingdom Topic: Cardiovascular epidemiology Mortality from cardiovascular disease has been falling in several countries with previously high rates. Irish CHD mortality rates fell dramatically from 1985 to 2000. Between 2000 and 2006 there was a further 45% decrease in CHD mortality rates amongst both men and women aged 2584 years (44% men; 46% women) in Ireland, i.e. 2315 fewer deaths than expected or ‘deaths prevented or postponed (DPPs)’ between 2000 and 2006. Objective: the aim of this study was to use the validated IMPACT CHD mortality model to examine the CHD mortality fall in Ireland between 2000 and 2006; to determine the contribution of risk factor changes and \"evidence based\" treatments to this decline; and to compare with similar analyses for 1985-2000. Methods: the cell-based IMPACT CHD mortality model in Microsoft Excel has been described in detail elsewhere. Data on risk factors was obtained from the SLû N 1998, 2002 and 2007 health and lifestyle surveys. Medical treatment data was available from the national prescribing databases, the Heartwatch programme for secondary prevention therapy in primary care, as well as the EUROASPIRE II and III (2001) and EUROHeart Failure I and II surveys. Results: approximately half of the decrease in CHD deaths between 2000 and 2006 were attributed to improvements in uptake of treatments (48%), particularly secondary prevention (15%), and treatments for chronic angina (11%) and for heart failure in the community and hospital (12%). For risk factors, the largest contribution came from reductions in population cholesterol (25%). Reduction in smoking contributed a disappointing 6% (compared with 26% in 1985-2000 comparisons); reflecting little progress in smoking cessation since 2000. There was little evidence of an improvement in population blood pressure reduction, or physical activity levels. There was further deterioration in the rates of diabetes and obesity since 2000, which is contributing to increased deaths from CHD. Conclusion: the substantial decrease in CHD mortality in Ireland continues in both men and women. Important contributors include reductions in total cholesterol levels in the population, a slight reduction in smoking prevalence, and increased medical and surgical interventions. Despite these positive changes, the continued increase in levels of obesity and diabetes could result in the adverse trends recently observed in other countries such as the UK, US and Australia, with a reversal of the mortality decline, particularly among the youngest groups.","PeriodicalId":50492,"journal":{"name":"European Journal of Cardiovascular Prevention & Rehabilitation","volume":"16 1","pages":"S1 - S3"},"PeriodicalIF":0.0,"publicationDate":"2009-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/17418267090160s101","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"65490976","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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