Pub Date : 2009-05-01DOI: 10.1177/17418267090160s116
{"title":"Oral Session VI. Exercise testing in chronic heart failure. How to treat exercise","authors":"","doi":"10.1177/17418267090160s116","DOIUrl":"https://doi.org/10.1177/17418267090160s116","url":null,"abstract":"","PeriodicalId":50492,"journal":{"name":"European Journal of Cardiovascular Prevention & Rehabilitation","volume":"16 1","pages":"S119 - S120"},"PeriodicalIF":0.0,"publicationDate":"2009-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/17418267090160s116","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"65490946","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2009-02-01DOI: 10.1097/01.01.hjr.0b013e3280128747
A. Rosengren, S. Maugeri
Dr Ugo Corrà Professor Annika Rosengren Salvatore Maugeri Foundation The Cardiovascular Institute IRCCS, Cardiology Department Gr för kardiovascular forskn Medical Centre of Veruno Medicin, plan 2 CK Via Revislate 13 SU/Östra I-28010 Veruno, Italy 416 85 Göteborg, Austria Tel: + 39 0322 884711 Tel: + 46 31 343 4086 Fax: + 32 0322 884816 Fax: + 46 31 259 254 E-mail: ugo.corra@fsm.it E-mail: annika.rosengren@hjl.gu.se
{"title":"News and Notices","authors":"A. Rosengren, S. Maugeri","doi":"10.1097/01.01.hjr.0b013e3280128747","DOIUrl":"https://doi.org/10.1097/01.01.hjr.0b013e3280128747","url":null,"abstract":"Dr Ugo Corrà Professor Annika Rosengren Salvatore Maugeri Foundation The Cardiovascular Institute IRCCS, Cardiology Department Gr för kardiovascular forskn Medical Centre of Veruno Medicin, plan 2 CK Via Revislate 13 SU/Östra I-28010 Veruno, Italy 416 85 Göteborg, Austria Tel: + 39 0322 884711 Tel: + 46 31 343 4086 Fax: + 32 0322 884816 Fax: + 46 31 259 254 E-mail: ugo.corra@fsm.it E-mail: annika.rosengren@hjl.gu.se","PeriodicalId":50492,"journal":{"name":"European Journal of Cardiovascular Prevention & Rehabilitation","volume":"16 1","pages":"117 - 120"},"PeriodicalIF":0.0,"publicationDate":"2009-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"61669337","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2008-05-01DOI: 10.1097/01.hjr.0000316901.20513.db
S. Giampaoli, R. Rielli, C. Donfrancesco, P. S. Caiola, ’. LDematte, G. Laurendi, M. D. Rosa, A. Addis, L. Palmieri, C. Pisinger, C. Glumer, U. Toft, L. V. H. Smith, M. Aadahl, K. Borch-Johnsen, T. Jørgensen, Reg Upshur, H. Lynn, T. Crichton, DE Stewart, DA Alter, PJ Harvey, SL Grace, K. Corace, SM Barry-Bianchi
A sustainable community action for cardiovascular prevention: the CUORE Project experience S Giampaoli; R Rielli; C Donfrancesco; P De Sanctis Caiola; L Dematte’; G Laurendi; M De Rosa; A Addis; L Palmieri Istituto Superiore di Sanita’, Rome, Italy; CINECA Consorzio Interuniversitario, Bologna, Italy; Ministero della Salute, Rome, Italy; Agenzia Italiana del Farmaco, Rome, Italy Purpose: Assessment of global absolute cardiovascular risk (GACR) using the Italian risk score of the CUORE Project was recently introduced in Italy and a plan for primary prevention of cardiovascular disease was implemented involving general practitioners (GPs). GACR function is based on gender, age, diabetes, smoking habit, systolic blood pressure, total and HDL-cholesterol and anti-hypertensive medication; it considers fatal and non fatal first coronary and cerebrovascular events as end-points. The preventive plan aims to reduce/maintain the Italian population at favourable risk profile. Methods: The implementation of the preventive plan includes: 1. website from which GPs may download the cuore.exe software to assess 10year GACR in men and women ages 35-69 years free of cardiovascular diseases; 2. national training course on the assessment of GACR, risk communication, healthy lifestyle counselling, medication treatment; 3. self-training module to collect data using the cuore.exe software; 4. accessible web-site tool--the Observatory of GACR--to pool data collected by GPs, support GPs with quality control, disseminate results in order to monitor GACR by genders, age and geographical area and evaluate its efficacy in primary care. Results: Presently, 2,858 health professionals have downloaded the cuore. exe software, 3,500 GPs attended the training course (1,800 residential; 1,700 e-learning) and used the self-training module. Data were collected and sent to the Observatory of GACR by 219 GPs. GACR was calculated for 13,709 persons: 701 men and 34 women were found at high risk (=20%); 4,089 men and 2,773 women at adverse risk to be kept under control by lifestyle; 1,960 men and 4,152 women at low risk (<3%). Conclusion: The preventive plan launched within the CUORE Project is expected to be feasible thanks to the support by the Ministry of Health, National Institute of Health and Italian Drug Agency and the involvement of GPs, cardiologists and other health professionals. The Observatory of the GACR is expected to become an important tool for encouraging GPs to shift interest from care to prevention, improving the quality of data collected in clinical practice, monitoring cardiovascular risk and risk factors, planning further preventive actions, and supporting policy makers at national and regional level.
预防心血管疾病的可持续社区行动:CUORE项目经验S GiampaoliR Rielli;C Donfrancesco;P De Sanctis Caiola;L Dematte ';G Laurendi;德·罗莎先生;艾迪斯;L Palmieri instituto Superiore di Sanita '，罗马，意大利;意大利博洛尼亚CINECA国际大学联盟;致敬部长，罗马，意大利;目的:意大利最近引入了使用CUORE项目的意大利风险评分来评估全球绝对心血管风险(GACR)，并实施了一项涉及全科医生(gp)的心血管疾病一级预防计划。GACR功能基于性别、年龄、糖尿病、吸烟习惯、收缩压、总胆固醇和高密度脂蛋白胆固醇以及抗高血压药物;它考虑致命和非致命的第一冠状动脉和脑血管事件作为终点。预防计划的目的是减少/保持意大利人口处于有利的风险状况。方法:预防方案的实施包括:1.预防方案的实施。全科医生可从该网站下载cuore.exe软件，评估35-69岁无心血管疾病的男性和女性10年GACR;2. 关于GACR评估、风险沟通、健康生活方式咨询、药物治疗的国家培训课程;3.自我训练模块使用cuore.exe软件采集数据;4. 可访问的网站工具——GACR观察站——汇集全科医生收集的数据，支持全科医生进行质量控制，传播结果，以便按性别、年龄和地理区域监测GACR，并评估其在初级保健中的效果。结果:目前已有2858名卫生专业人员下载了该软件。3500名全科医生参加了培训课程(1800名住校;1700在线学习)，并使用了自我培训模块。数据由219个GPs收集并发送给GACR天文台。计算了13709人的GACR: 701名男性和34名女性处于高风险(=20%);4089名男性和2773名女性存在不良风险，需通过生活方式加以控制;1960名男性和4152名女性处于低风险(<3%)。结论:由于卫生部、国家卫生研究所和意大利药品管理局的支持以及全科医生、心脏病专家和其他卫生专业人员的参与，预计在CUORE项目内启动的预防计划是可行的。预计GACR观察站将成为一个重要工具，鼓励全科医生将兴趣从护理转向预防，提高临床实践中收集的数据质量，监测心血管风险和风险因素，规划进一步的预防行动，并支持国家和区域一级的决策者。
{"title":"ORAL ABSTRACT SESSION: Risk factor intervention. From population to patient: Thursday, 1 May 2008, 13:30–14:30 Location: Bordeaux","authors":"S. Giampaoli, R. Rielli, C. Donfrancesco, P. S. Caiola, ’. LDematte, G. Laurendi, M. D. Rosa, A. Addis, L. Palmieri, C. Pisinger, C. Glumer, U. Toft, L. V. H. Smith, M. Aadahl, K. Borch-Johnsen, T. Jørgensen, Reg Upshur, H. Lynn, T. Crichton, DE Stewart, DA Alter, PJ Harvey, SL Grace, K. Corace, SM Barry-Bianchi","doi":"10.1097/01.hjr.0000316901.20513.db","DOIUrl":"https://doi.org/10.1097/01.hjr.0000316901.20513.db","url":null,"abstract":"A sustainable community action for cardiovascular prevention: the CUORE Project experience S Giampaoli; R Rielli; C Donfrancesco; P De Sanctis Caiola; L Dematte’; G Laurendi; M De Rosa; A Addis; L Palmieri Istituto Superiore di Sanita’, Rome, Italy; CINECA Consorzio Interuniversitario, Bologna, Italy; Ministero della Salute, Rome, Italy; Agenzia Italiana del Farmaco, Rome, Italy Purpose: Assessment of global absolute cardiovascular risk (GACR) using the Italian risk score of the CUORE Project was recently introduced in Italy and a plan for primary prevention of cardiovascular disease was implemented involving general practitioners (GPs). GACR function is based on gender, age, diabetes, smoking habit, systolic blood pressure, total and HDL-cholesterol and anti-hypertensive medication; it considers fatal and non fatal first coronary and cerebrovascular events as end-points. The preventive plan aims to reduce/maintain the Italian population at favourable risk profile. Methods: The implementation of the preventive plan includes: 1. website from which GPs may download the cuore.exe software to assess 10year GACR in men and women ages 35-69 years free of cardiovascular diseases; 2. national training course on the assessment of GACR, risk communication, healthy lifestyle counselling, medication treatment; 3. self-training module to collect data using the cuore.exe software; 4. accessible web-site tool--the Observatory of GACR--to pool data collected by GPs, support GPs with quality control, disseminate results in order to monitor GACR by genders, age and geographical area and evaluate its efficacy in primary care. Results: Presently, 2,858 health professionals have downloaded the cuore. exe software, 3,500 GPs attended the training course (1,800 residential; 1,700 e-learning) and used the self-training module. Data were collected and sent to the Observatory of GACR by 219 GPs. GACR was calculated for 13,709 persons: 701 men and 34 women were found at high risk (=20%); 4,089 men and 2,773 women at adverse risk to be kept under control by lifestyle; 1,960 men and 4,152 women at low risk (<3%). Conclusion: The preventive plan launched within the CUORE Project is expected to be feasible thanks to the support by the Ministry of Health, National Institute of Health and Italian Drug Agency and the involvement of GPs, cardiologists and other health professionals. The Observatory of the GACR is expected to become an important tool for encouraging GPs to shift interest from care to prevention, improving the quality of data collected in clinical practice, monitoring cardiovascular risk and risk factors, planning further preventive actions, and supporting policy makers at national and regional level.","PeriodicalId":50492,"journal":{"name":"European Journal of Cardiovascular Prevention & Rehabilitation","volume":"15 1","pages":"S32 - S33"},"PeriodicalIF":0.0,"publicationDate":"2008-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1097/01.hjr.0000316901.20513.db","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"61597552","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2008-05-01DOI: 10.1097/01.hjr.0000317041.24143.8d
M. Santos, Eca, Veiga, El, Antonio, Ds, Bocalini, A. Santos, S. Palomino, P. Tucci, M. Higuchi, R. Maranhão, B. Giusti
Previous exercise training is associated with lower local levels of apoptosis and inflammatory markers after myocardial infarction in rats M Santos; ECA Veiga; EL Antonio; DS Bocalini; AA Santos; SA Palomino; PJF Tucci; ML Higuchi; RC Maranhao INCOR-HCFMUSP Pathology, Sao Paulo, Brazil; EPM-UNIFESP Cardiac Physiology Lab, Sao Paulo, Brazil; InCor-HC FMUSP Pathology Lab, Sao Paulo, Brazil Apoptosis, and inflammatory modulators, such as NF-kB and TNF-alpha participate in cardiovascular remodeling after myocardial infarction (MI) and are associated with heart failure. Physical exercise reduces cardiovascular morbidity and mortality. The cardioprotective effects of exercise training include higher myocardial tolerance to ischemiareperfusion, improved cardiac performance and higher cell defense capacity against stress. Here we evaluated the effects of previous exercise training on myocardial levels of apoptosis, NF-kB and TNF-alpha 4 weeks after MI. Methods: 20 Wistar rats were randomly distributed in groups: Sedentary (S); Exercise (E); Sedentary plus MI (SI); Exercise plus MI (EI). Exercise training consisted in 8 wks of swimming; 1h/day, 5d/wk. MI was performed through surgical ligation of the left coronary artery. 4 wks after MI animals were submitted to echocardiographic study and sacrificed and the heart was excised and prepared for histological studies. Apoptosis was detected by TUNEL. Rabbit polyclonal antibody antiNFkB p65 and anti-TNF alpha were used for immunohistochemistry. Quantification of % positive area for each antigen was performed through an Automatic Color Detector Analysis System. Results: The number of apoptotic cells/20x field was higher in SI comparing to EI, in both infarcted myocardium and infarct border zone (3.97±0.27 vs 1.9±0.81, P=0.04 and 3.67±0.33 vs1.56±0.48, P=0.007, respectively). Comparing to EI, SI group had higher % positive area for NF-kB and TNF-alpha antigen at myocardium infarcted area (0.53±0.12 vs 0.26±0.06, P=0.08 and 1.72±0.24 vs 0.62±0.18, P=0.01). Conclusion:MI in previously trained animals was associated with lower levels of apoptosis, TNF-alpha and NF-kB. Physical exercise training promotes a better immune response against myocardial infarction that can lead to better functional outcomes. These results reinforce the need to develop cardiovascular prevention programs with exercise.
先前的运动训练与大鼠心肌梗死后较低的局部细胞凋亡和炎症标志物水平有关。ECA Veiga;EL安东尼奥;DS Bocalini;AA桑托斯;SA帕洛米诺马;PJF Tucci;毫升Higuchi;RC Maranhao INCOR-HCFMUSP病理学，巴西圣保罗;EPM-UNIFESP心脏生理实验室，巴西圣保罗;细胞凋亡和炎症调节剂，如NF-kB和tnf - α参与心肌梗死(MI)后的心血管重塑，并与心力衰竭相关。体育锻炼可以降低心血管疾病的发病率和死亡率。运动训练的心脏保护作用包括提高心肌对缺血再灌注的耐受性，改善心脏性能和提高细胞对应激的防御能力。在这里，我们评估了先前的运动训练对心肌梗死后4周心肌细胞凋亡、NF-kB和tnf - α水平的影响。方法:20只Wistar大鼠随机分为两组:久坐(S);运动(E);久坐加心肌梗死(SI);运动加MI (EI)。运动训练包括8周的游泳;1小时/天,5 d /周。心肌梗死通过手术结扎左冠状动脉。心肌梗死后4周，动物接受超声心动图研究并处死，切除心脏，准备进行组织学研究。TUNEL法检测细胞凋亡。免疫组化采用兔抗infkb p65和抗tnf α多克隆抗体。通过自动颜色检测器分析系统对每种抗原的%阳性面积进行定量。结果:梗死心肌及梗死边界区凋亡细胞数(3.97±0.27 vs 1.9±0.81,P=0.04)均高于EI(3.67±0.33 vs1.56±0.48,P=0.007)。与EI组相比，SI组心肌梗死区NF-kB和tnf - α抗原%阳性面积(0.53±0.12 vs 0.26±0.06,P=0.08)和(1.72±0.24 vs 0.62±0.18,P=0.01)高于EI组。结论:先前训练动物的心肌梗死与较低水平的细胞凋亡、tnf - α和NF-kB有关。体育锻炼可以促进对心肌梗死的更好的免疫反应，从而导致更好的功能结果。这些结果加强了通过锻炼来制定心血管预防计划的必要性。
{"title":"ORAL ABSTRACT SESSION: Mechanisms of exercise in heart failure: news from translational research: Friday, 2 May 2008, 9:00–10:30 Location: Room 352","authors":"M. Santos, Eca, Veiga, El, Antonio, Ds, Bocalini, A. Santos, S. Palomino, P. Tucci, M. Higuchi, R. Maranhão, B. Giusti","doi":"10.1097/01.hjr.0000317041.24143.8d","DOIUrl":"https://doi.org/10.1097/01.hjr.0000317041.24143.8d","url":null,"abstract":"Previous exercise training is associated with lower local levels of apoptosis and inflammatory markers after myocardial infarction in rats M Santos; ECA Veiga; EL Antonio; DS Bocalini; AA Santos; SA Palomino; PJF Tucci; ML Higuchi; RC Maranhao INCOR-HCFMUSP Pathology, Sao Paulo, Brazil; EPM-UNIFESP Cardiac Physiology Lab, Sao Paulo, Brazil; InCor-HC FMUSP Pathology Lab, Sao Paulo, Brazil Apoptosis, and inflammatory modulators, such as NF-kB and TNF-alpha participate in cardiovascular remodeling after myocardial infarction (MI) and are associated with heart failure. Physical exercise reduces cardiovascular morbidity and mortality. The cardioprotective effects of exercise training include higher myocardial tolerance to ischemiareperfusion, improved cardiac performance and higher cell defense capacity against stress. Here we evaluated the effects of previous exercise training on myocardial levels of apoptosis, NF-kB and TNF-alpha 4 weeks after MI. Methods: 20 Wistar rats were randomly distributed in groups: Sedentary (S); Exercise (E); Sedentary plus MI (SI); Exercise plus MI (EI). Exercise training consisted in 8 wks of swimming; 1h/day, 5d/wk. MI was performed through surgical ligation of the left coronary artery. 4 wks after MI animals were submitted to echocardiographic study and sacrificed and the heart was excised and prepared for histological studies. Apoptosis was detected by TUNEL. Rabbit polyclonal antibody antiNFkB p65 and anti-TNF alpha were used for immunohistochemistry. Quantification of % positive area for each antigen was performed through an Automatic Color Detector Analysis System. Results: The number of apoptotic cells/20x field was higher in SI comparing to EI, in both infarcted myocardium and infarct border zone (3.97±0.27 vs 1.9±0.81, P=0.04 and 3.67±0.33 vs1.56±0.48, P=0.007, respectively). Comparing to EI, SI group had higher % positive area for NF-kB and TNF-alpha antigen at myocardium infarcted area (0.53±0.12 vs 0.26±0.06, P=0.08 and 1.72±0.24 vs 0.62±0.18, P=0.01). Conclusion:MI in previously trained animals was associated with lower levels of apoptosis, TNF-alpha and NF-kB. Physical exercise training promotes a better immune response against myocardial infarction that can lead to better functional outcomes. These results reinforce the need to develop cardiovascular prevention programs with exercise.","PeriodicalId":50492,"journal":{"name":"European Journal of Cardiovascular Prevention & Rehabilitation","volume":"15 1","pages":"S70 - S71"},"PeriodicalIF":0.0,"publicationDate":"2008-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1097/01.hjr.0000317041.24143.8d","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"61597618","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2008-05-01DOI: 10.1097/01.hjr.0000316905.73878.86
T. Suvorava, S. Kumpf, V. Adams, G. Kojda, F. Canoui-Poitrine, G. Luc, D. Arveiler, J. Ferrières, A. Bingham, A. Evans
R Mitsutake; S Miura; B Zhang; K Saku Fukuoka University Hospital Cardiology, Fukuoka, Japan Background: A relationship has been noted between lower levels of HDL-associated phospholipid and atherosclerotic coronary artery disease (CAD). The aim of this study was to assess the relationship between numerous lipidemic factors and severity of CAD as evaluated by multi-detector row computed tomography (MDCT). Methods and Results: Subjects included 195 consecutive patients who underwent coronary angiography using MDCT because of suspected CAD. Coronary artery calcification (CAC) score and Gensini’s score (GS) as evaluated by MDCT, platelet-activating factor acetylhydrolase (PAF-AH), free cholesterol (FC), phospholipid (PL), remnant-like lipoprotein particle-cholesterol (RLP-C), apolipoprotein (apo)-C, apo-B, apo-C3, apo-E, highly-sensitive CRP were determined. The number of the significant coronary vessel disease (VD) was determined using MDCT. The number of VD was significantly associated with HDL-C, HDL-associated HDL-C, HDL-associated PL, HDL-associated FC and RLP-C. Logistic regression analysis revealed that the number of VD was most closely correlated with HDL-C levels (p=0.02). GS was significantly associated with age, HDL cholesterol, hemoglobin A1c, HDLassociated PAF-AH, HDL-associated FC and HDL-associated phospholipid. Multivariate analysis revealed that GS was most closely correlated with HDL-associated phospholipid (p=0.02). Conclusion: Lower levels of HDL-associated phospholipid may be an indicator and provide additional information regarding the severity of CAD compared with other lipidemic factors.
R Mitsutake;三浦;B张;背景:低水平的高密度脂蛋白相关磷脂与动脉粥样硬化性冠状动脉疾病(CAD)之间存在关系。本研究的目的是通过多检测器行计算机断层扫描(MDCT)评估多种血脂因素与CAD严重程度之间的关系。方法和结果:研究对象包括195例因疑似冠心病而连续行冠状动脉造影的患者。采用MDCT评价冠状动脉钙化(CAC)评分和Gensini评分(GS)，测定血小板活化因子乙酰水解酶(PAF-AH)、游离胆固醇(FC)、磷脂(PL)、残余样脂蛋白颗粒-胆固醇(RLP-C)、载脂蛋白(apo)-C、载脂蛋白b、载脂蛋白c3、载脂蛋白e、高敏感CRP。采用多层螺旋ct检测显著性冠状动脉病变(VD)的数量。VD数量与HDL-C、HDL-C、hdl - PL、hdl - FC和RLP-C显著相关。Logistic回归分析显示，VD数量与HDL-C水平关系最为密切(p=0.02)。GS与年龄、HDL胆固醇、血红蛋白A1c、HDL相关PAF-AH、HDL相关FC和HDL相关磷脂显著相关。多因素分析显示，GS与hdl相关磷脂最密切相关(p=0.02)。结论:与其他血脂因子相比，较低的高密度脂蛋白相关磷脂水平可能是一个指标，并提供有关冠心病严重程度的额外信息。
{"title":"POSTER SESSION 2: Thursday, 1 May 2008, 13:30–18:00 Location: Poster Area","authors":"T. Suvorava, S. Kumpf, V. Adams, G. Kojda, F. Canoui-Poitrine, G. Luc, D. Arveiler, J. Ferrières, A. Bingham, A. Evans","doi":"10.1097/01.hjr.0000316905.73878.86","DOIUrl":"https://doi.org/10.1097/01.hjr.0000316905.73878.86","url":null,"abstract":"R Mitsutake; S Miura; B Zhang; K Saku Fukuoka University Hospital Cardiology, Fukuoka, Japan Background: A relationship has been noted between lower levels of HDL-associated phospholipid and atherosclerotic coronary artery disease (CAD). The aim of this study was to assess the relationship between numerous lipidemic factors and severity of CAD as evaluated by multi-detector row computed tomography (MDCT). Methods and Results: Subjects included 195 consecutive patients who underwent coronary angiography using MDCT because of suspected CAD. Coronary artery calcification (CAC) score and Gensini’s score (GS) as evaluated by MDCT, platelet-activating factor acetylhydrolase (PAF-AH), free cholesterol (FC), phospholipid (PL), remnant-like lipoprotein particle-cholesterol (RLP-C), apolipoprotein (apo)-C, apo-B, apo-C3, apo-E, highly-sensitive CRP were determined. The number of the significant coronary vessel disease (VD) was determined using MDCT. The number of VD was significantly associated with HDL-C, HDL-associated HDL-C, HDL-associated PL, HDL-associated FC and RLP-C. Logistic regression analysis revealed that the number of VD was most closely correlated with HDL-C levels (p=0.02). GS was significantly associated with age, HDL cholesterol, hemoglobin A1c, HDLassociated PAF-AH, HDL-associated FC and HDL-associated phospholipid. Multivariate analysis revealed that GS was most closely correlated with HDL-associated phospholipid (p=0.02). Conclusion: Lower levels of HDL-associated phospholipid may be an indicator and provide additional information regarding the severity of CAD compared with other lipidemic factors.","PeriodicalId":50492,"journal":{"name":"European Journal of Cardiovascular Prevention & Rehabilitation","volume":"15 1","pages":"S40 - S67"},"PeriodicalIF":0.0,"publicationDate":"2008-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1097/01.hjr.0000316905.73878.86","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"61597606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2008-05-01DOI: 10.1097/01.hjr.0000317043.01272.df
M Zurek; RK Binder; H Saner; J-P Schmid Swiss Cardiovascular Centre Bern, Bern, Switzerland Purpose: Exercise oscillatory ventilation (EOV) is a respiratory pattern associated with severe chronic heart failure (CHF) and a predictor of poor prognosis. Cardiac rehabilitation (CR) is known to improve maximal exercise capacity and ventilatory efficiency in CHF patients (pts). However, the effect of CR on EOV is unknown. Methods: 20 CHF pts with EOV (mean age 59±9.3 years, LVEF 28.2 ±8.4%, peak VO2 16.3±3.4ml/min/kg) and 40 CHF pts without EOV (mean age 59±8.6 years, LVEF 27.2±8.8 %, peak VO2 18.6±4.6ml/min/ kg) underwent symptom limited cardiopulmonary exercise testing (CPET) on an upright bicycle ergometer before and after a 3 months outpatient CR programme. For the definition of EOV all of the following criteria had to be fulfilled: (1) 2 or more regular oscillatory fluctuations in VE; (2) minimal average amplitude of ventilatory oscillation of 5L; (3) a regular oscillation as defined by a standard deviation of 3 consecutive cycle lengths within 20% of the average. Magnitude of EOV was measured by the variation coefficient of minute ventilation (MV) during unloaded cycling and during incremental exercise by the correlation coefficient of MV. Results: Variation and correlation coefficient of MV significantly differed between pts with and without EOV before and after training (p<0.001). In pts with EOV both coefficients improved after CR (p<0.001 and p=0.004, respectively) whereas in the control group it remained unchanged (p=0.592 and p=0.617, respectively). In EOV pts VE/VCO2-slope significantly decreased from 36.6±6.9 to 30.7±5.9 (p=0.002) while PETCO2 significantly improved from 31.8±3.1 to 37.9 ±5.5 (p=0.001). The change in VE/VCO2-slope was significantly higher (p<0.019) than in the control group (change of PETCO2: p=0.063). The changes in the amplitude of EOV correlated significantly with changes in PETCO2 (r=0.667, p=0.007) and changes in VE/VCO2slope (r=0.591, p=0.02). Conclusion: EOV is sensitive to regular physical exercise training and improves after a 3 months CR programme. The amelioration of EOV correlates significantly with VE/VCO2 and PETCO2 . The impact of this amelioration on prognosis however remains to be shown.
{"title":"POSTER SESSION 3: Friday, 2 May 2008, 8:00–13:00 Location: Poster Area","authors":"","doi":"10.1097/01.hjr.0000317043.01272.df","DOIUrl":"https://doi.org/10.1097/01.hjr.0000317043.01272.df","url":null,"abstract":"M Zurek; RK Binder; H Saner; J-P Schmid Swiss Cardiovascular Centre Bern, Bern, Switzerland Purpose: Exercise oscillatory ventilation (EOV) is a respiratory pattern associated with severe chronic heart failure (CHF) and a predictor of poor prognosis. Cardiac rehabilitation (CR) is known to improve maximal exercise capacity and ventilatory efficiency in CHF patients (pts). However, the effect of CR on EOV is unknown. Methods: 20 CHF pts with EOV (mean age 59±9.3 years, LVEF 28.2 ±8.4%, peak VO2 16.3±3.4ml/min/kg) and 40 CHF pts without EOV (mean age 59±8.6 years, LVEF 27.2±8.8 %, peak VO2 18.6±4.6ml/min/ kg) underwent symptom limited cardiopulmonary exercise testing (CPET) on an upright bicycle ergometer before and after a 3 months outpatient CR programme. For the definition of EOV all of the following criteria had to be fulfilled: (1) 2 or more regular oscillatory fluctuations in VE; (2) minimal average amplitude of ventilatory oscillation of 5L; (3) a regular oscillation as defined by a standard deviation of 3 consecutive cycle lengths within 20% of the average. Magnitude of EOV was measured by the variation coefficient of minute ventilation (MV) during unloaded cycling and during incremental exercise by the correlation coefficient of MV. Results: Variation and correlation coefficient of MV significantly differed between pts with and without EOV before and after training (p<0.001). In pts with EOV both coefficients improved after CR (p<0.001 and p=0.004, respectively) whereas in the control group it remained unchanged (p=0.592 and p=0.617, respectively). In EOV pts VE/VCO2-slope significantly decreased from 36.6±6.9 to 30.7±5.9 (p=0.002) while PETCO2 significantly improved from 31.8±3.1 to 37.9 ±5.5 (p=0.001). The change in VE/VCO2-slope was significantly higher (p<0.019) than in the control group (change of PETCO2: p=0.063). The changes in the amplitude of EOV correlated significantly with changes in PETCO2 (r=0.667, p=0.007) and changes in VE/VCO2slope (r=0.591, p=0.02). Conclusion: EOV is sensitive to regular physical exercise training and improves after a 3 months CR programme. The amelioration of EOV correlates significantly with VE/VCO2 and PETCO2 . The impact of this amelioration on prognosis however remains to be shown.","PeriodicalId":50492,"journal":{"name":"European Journal of Cardiovascular Prevention & Rehabilitation","volume":"1 1","pages":"S102 - S74"},"PeriodicalIF":0.0,"publicationDate":"2008-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1097/01.hjr.0000317043.01272.df","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"61597661","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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