Pub Date : 2010-05-01DOI: 10.1177/17418267100170s218
A. Hingorani, A. Jones, M. Charakida, D. Lawlor, Gd Smith, Sattar, J. Deanfield, C. Fischbacher, H. Brown, S. Capewell
295 Prevalence and clinical significance of aortic root dilatation in highly-trained, competitive athletes B Di Giacinto, E De Blasiis, FM Di Paolo, FM Quattrini, C Pisicchio, E Guerra, R Ciardo, A Pelliccia Institute of Sport Medicine and Science, CONI, Rome, Italy Topic: Sports cardiology Purpose: Prevalence, clinical significance, and long-term consequences of aortic root (AoR) dilatation in competitive athletes are not yet investigated. Our aim was to assess the distribution and determinants of AoR size in a large population of competitive athletes. Methods: AoR dimension were assessed by echocardiography in 2,361 athletes participating in 48 different sports. Of them, 44 were excluded because aortic structural abnormalities, such as bicuspid aortic valve, Marfan s Syndrome, aortic prosthesis. The remaining 2,317, including 1,300 (56%) males and 1,017 (44%) females were the study population. Arbitrary cut-off of =40 mm, according to #36th Bethesda Conference, was used as upper normal limits for AoR. Results: In males AoR was 32.2 2.7 mm (range 23-44) and the 95th percentile was 37 mm. In females AoR was 27.5 2.6 mm (20-36) and the 95th percentile was 32 mm.Multiple regression and covariance analysis showed AoR dimension largely explained by body surface area, left ventricular mass and age (R21⁄4 0.61), with type of sports participation having only a modest effect. The AoR was<40 mm in 2,300 athletes (99%), and = 40 mm in only 17 (1%), all male. In this subset, aortic dimension increased over a 8 5 year follow-up (40.9 1.3 to 42.9 3.6 mm; p <0.01), including 3 former athletes in whomAoR become dilated (to 50mm, 50mm and 48mm) after 15-16 years, in the absence of symptoms or evidence of systemic disease. Conclusion:Dilatation of the aortic root ( =40 mm) is rare in highly trained athletes and is not a consistent feature of‘‘athlete s heart’’. Longitudinal assessment in athletes with AoR =40 mm showed further dimensional increase, which occasionally was very marked. Selective restriction from most intense competitive sports may be indicated in these athletes to reduce the risk associated with accelerated aortic enlargement.
295高训练竞技运动员主动脉根扩张的患病率和临床意义B Di Giacinto, E De Blasiis, FM Di Paolo, FM Quattrini, C Pisicchio, E Guerra, R Ciardo, A peliccia运动医学与科学研究所，CONI, Rome, Italy题目:运动心脏病学目的:竞技运动员主动脉根(AoR)扩张的患病率、临床意义和长期后果尚未调查。我们的目的是评估大量竞技运动员AoR大小的分布和决定因素。方法:采用超声心动图对参加48项运动的2361名运动员进行AoR维度评估。其中因二尖瓣主动脉瓣、马凡氏综合征、主动脉假体等主动脉结构异常排除44例。其余2,317人，包括1,300名(56%)男性和1,017名(44%)女性为研究人群。根据#36 Bethesda会议，任意截断=40 mm作为AoR的正常上限。结果:男性AoR为32.2 ~ 2.7 mm(范围23 ~ 44)，第95百分位为37 mm。女性AoR为27.5 - 2.6 mm(20-36)，第95百分位为32 mm。多元回归和协方差分析显示，AoR维度主要由体表面积、左心室质量和年龄解释(R21 / 4 0.61)，运动类型对AoR维度影响不大。2300名运动员(99%)AoR <40 mm，只有17名(1%)运动员AoR = 40 mm，均为男性。在这个亚群中，在85年的随访中，主动脉尺寸增加(40.9 1.3至42.9 3.6 mm;p <0.01)，其中包括3名前运动员，在没有症状或全身性疾病证据的情况下，在15-16年后aor扩张(达到50mm, 50mm和48mm)。结论:主动脉根部扩张(=40 mm)在训练有素的运动员中很少见，并不是“运动员心脏”的一贯特征。AoR =40 mm的运动员的纵向评估显示进一步的尺寸增加，偶尔非常明显。在这些运动员中，选择性地限制最激烈的竞技运动可以减少与主动脉加速扩张相关的风险。
{"title":"Oral Abstract Session: Epidemiology and sports cardiology","authors":"A. Hingorani, A. Jones, M. Charakida, D. Lawlor, Gd Smith, Sattar, J. Deanfield, C. Fischbacher, H. Brown, S. Capewell","doi":"10.1177/17418267100170s218","DOIUrl":"https://doi.org/10.1177/17418267100170s218","url":null,"abstract":"295 Prevalence and clinical significance of aortic root dilatation in highly-trained, competitive athletes B Di Giacinto, E De Blasiis, FM Di Paolo, FM Quattrini, C Pisicchio, E Guerra, R Ciardo, A Pelliccia Institute of Sport Medicine and Science, CONI, Rome, Italy Topic: Sports cardiology Purpose: Prevalence, clinical significance, and long-term consequences of aortic root (AoR) dilatation in competitive athletes are not yet investigated. Our aim was to assess the distribution and determinants of AoR size in a large population of competitive athletes. Methods: AoR dimension were assessed by echocardiography in 2,361 athletes participating in 48 different sports. Of them, 44 were excluded because aortic structural abnormalities, such as bicuspid aortic valve, Marfan s Syndrome, aortic prosthesis. The remaining 2,317, including 1,300 (56%) males and 1,017 (44%) females were the study population. Arbitrary cut-off of =40 mm, according to #36th Bethesda Conference, was used as upper normal limits for AoR. Results: In males AoR was 32.2 2.7 mm (range 23-44) and the 95th percentile was 37 mm. In females AoR was 27.5 2.6 mm (20-36) and the 95th percentile was 32 mm.Multiple regression and covariance analysis showed AoR dimension largely explained by body surface area, left ventricular mass and age (R21⁄4 0.61), with type of sports participation having only a modest effect. The AoR was<40 mm in 2,300 athletes (99%), and = 40 mm in only 17 (1%), all male. In this subset, aortic dimension increased over a 8 5 year follow-up (40.9 1.3 to 42.9 3.6 mm; p <0.01), including 3 former athletes in whomAoR become dilated (to 50mm, 50mm and 48mm) after 15-16 years, in the absence of symptoms or evidence of systemic disease. Conclusion:Dilatation of the aortic root ( =40 mm) is rare in highly trained athletes and is not a consistent feature of‘‘athlete s heart’’. Longitudinal assessment in athletes with AoR =40 mm showed further dimensional increase, which occasionally was very marked. Selective restriction from most intense competitive sports may be indicated in these athletes to reduce the risk associated with accelerated aortic enlargement.","PeriodicalId":50492,"journal":{"name":"European Journal of Cardiovascular Prevention & Rehabilitation","volume":"78 1","pages":"S59 - S60"},"PeriodicalIF":0.0,"publicationDate":"2010-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/17418267100170s218","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"65491270","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2010-05-01DOI: 10.1177/17418267100170s220
S. Ramsay, P. Whincup, S. Hardoon, M. Thomas, R. Morris, -. SGWanna, Methee, P. Wohlfahrt, D. Palouš, M. Ingrischová, A. Krajčoviechová, J. Seidlerová, Adámková, J. Filipovský, R. Cífková
419 Have socioeconomic differences in coronary risk factors changed over 20 years? Results from a population-based study of men between 1978-80 and 1998-2000 SE Ramsay, PH Whincup, SL Hardoon, MC Thomas, RW Morris, SG Wannamethee University College London, London, United Kingdom, St George’s, University of London, London, United Kingdom Topic: Cardiovascular epidemiology Background: Although CHD mortality has declined in the UK population since the late 1970s, the decline has been particularly marked among more affluent subjects. While the decline substantially reflects improvements in established coronary risk factors, little is known about how these have changed in different socioeconomic groups. Aim: To examine whether socioeconomic differences in coronary risk factors in Britain have changed over 20 years between 1978-80 and 1998-2000. Methods: A socioeconomically representative cohort of men aged 40-59 years from 24 British towns was followed-up from 1978-80. Data on blood pressure, cholesterol, body mass index (BMI), cigarette smoking and physical activity were collected at baseline (1978-80) and in 19982000. Social class was based on the longest-held occupation in middle-age. Results: Overall, the prevalence of cigarette smoking declined and mean blood pressure and non-HDL cholesterol levels fell, while mean HDL cholesterol and BMI, and physical activity increased. The higher odds of being a current smoker in manual (lower) compared with nonmanual (higher) social classes in 2000 (age-adjusted odds ratio1⁄42.04; 95%CI 1.68, 2.47) had not changed since 1978-80 (p for interaction social class time 0.51). Men in manual occupations became less likely to be physically inactive compared with non-manual groups (p for interaction 0.04) and more likely to be moderate-vigorously active (p for interaction 0.005). The 20-year increase in mean BMI was 2.34 kg/m2 in the manual compared with 2.01 kg/m2 in the nonmanual group (difference in mean change 0.33 kg/m2; 95%CI 0.14, 0.53; p for interaction 0.001). Mean systolic blood pressure declined more in manual than non-manual groups (difference in mean change 3.6; 95%CI 2.1, 5.3, p for interaction <0.0001). Non-manual groups had a greater mean decline in non-HDL cholesterol (difference in mean change 0.18 mmol/l; 95%CI 0.11, 0.25, p for interaction <0.0001) and a greater mean increase in HDL-cholesterol (difference in mean change 0.04 mmol/l; 95%CI 0.02, 0.06, p for interaction < 0.0001). Conclusions: Since the 1980s, socioeconomic differences in physical activity and blood pressure may have been reduced, while those in cigarette smoking have persisted. Socioeconomic differences in BMI, non-HDL and HDL-cholesterol levels appeared to have worsened, with more unfavourable changes in lower socioeconomic groups. Continuing priority is needed to improve adverse cardiovascular risk profiles in socially disadvantaged groups in the UK.
{"title":"Young Investigators Awards Session","authors":"S. Ramsay, P. Whincup, S. Hardoon, M. Thomas, R. Morris, -. SGWanna, Methee, P. Wohlfahrt, D. Palouš, M. Ingrischová, A. Krajčoviechová, J. Seidlerová, Adámková, J. Filipovský, R. Cífková","doi":"10.1177/17418267100170s220","DOIUrl":"https://doi.org/10.1177/17418267100170s220","url":null,"abstract":"419 Have socioeconomic differences in coronary risk factors changed over 20 years? Results from a population-based study of men between 1978-80 and 1998-2000 SE Ramsay, PH Whincup, SL Hardoon, MC Thomas, RW Morris, SG Wannamethee University College London, London, United Kingdom, St George’s, University of London, London, United Kingdom Topic: Cardiovascular epidemiology Background: Although CHD mortality has declined in the UK population since the late 1970s, the decline has been particularly marked among more affluent subjects. While the decline substantially reflects improvements in established coronary risk factors, little is known about how these have changed in different socioeconomic groups. Aim: To examine whether socioeconomic differences in coronary risk factors in Britain have changed over 20 years between 1978-80 and 1998-2000. Methods: A socioeconomically representative cohort of men aged 40-59 years from 24 British towns was followed-up from 1978-80. Data on blood pressure, cholesterol, body mass index (BMI), cigarette smoking and physical activity were collected at baseline (1978-80) and in 19982000. Social class was based on the longest-held occupation in middle-age. Results: Overall, the prevalence of cigarette smoking declined and mean blood pressure and non-HDL cholesterol levels fell, while mean HDL cholesterol and BMI, and physical activity increased. The higher odds of being a current smoker in manual (lower) compared with nonmanual (higher) social classes in 2000 (age-adjusted odds ratio1⁄42.04; 95%CI 1.68, 2.47) had not changed since 1978-80 (p for interaction social class time 0.51). Men in manual occupations became less likely to be physically inactive compared with non-manual groups (p for interaction 0.04) and more likely to be moderate-vigorously active (p for interaction 0.005). The 20-year increase in mean BMI was 2.34 kg/m2 in the manual compared with 2.01 kg/m2 in the nonmanual group (difference in mean change 0.33 kg/m2; 95%CI 0.14, 0.53; p for interaction 0.001). Mean systolic blood pressure declined more in manual than non-manual groups (difference in mean change 3.6; 95%CI 2.1, 5.3, p for interaction <0.0001). Non-manual groups had a greater mean decline in non-HDL cholesterol (difference in mean change 0.18 mmol/l; 95%CI 0.11, 0.25, p for interaction <0.0001) and a greater mean increase in HDL-cholesterol (difference in mean change 0.04 mmol/l; 95%CI 0.02, 0.06, p for interaction < 0.0001). Conclusions: Since the 1980s, socioeconomic differences in physical activity and blood pressure may have been reduced, while those in cigarette smoking have persisted. Socioeconomic differences in BMI, non-HDL and HDL-cholesterol levels appeared to have worsened, with more unfavourable changes in lower socioeconomic groups. Continuing priority is needed to improve adverse cardiovascular risk profiles in socially disadvantaged groups in the UK.","PeriodicalId":50492,"journal":{"name":"European Journal of Cardiovascular Prevention & Rehabilitation","volume":"17 1","pages":"S63 - S64"},"PeriodicalIF":0.0,"publicationDate":"2010-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/17418267100170s220","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"65491329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2010-05-01DOI: 10.1177/17418267100170s226
Nicole MPanhuyzen-Goedkoop, R. Terink, Jlrm Smeets, A. Kassim, KA Treusch, A. Fruend, C. Beller, M. Vlachojannis, K. Erdsiek, F. Van, Buuren, K.-P. Mellwig
P398 Blood pressure response to exercise in young athletes associated with classification of sports N M Nicole MPanhuyzen-Goedkoop, R Terink, JLRM Smeets Radboud University Nijmegen Medical Centre, Heartlung Centre, Nijmegen, Netherlands, Sports Medical Center Papendal, Arnhem, Netherlands Topic: Sports cardiology Purpose: hemodynamic responses to maximal exercise testing cover the general population. Bloodpressure (BP) responses in athletes are reported at rest and during ambulatory BP monitoring. BP responses associated with different classes of sports are lacking. Purpose: To determine BP responses to exercise related to different classes of sports in young athletes (=35yr). Methods: Young athletes who had pre-participation cardiovascular screening, maximal exerciseECG, and were engaged in regular physical training and competition > previous 6 month were included in this retrospective study during 2000-2008. Bicycle exercise protocol until exertion, 75 watt (men) or 50 watt (women) during 4min, increment 25 watt / 2 min. BP and ECG at rest, each increment, and recovery phase was measured manually. Results: 475 athletes were included, 308 men and 167 women, age 9-35yr (mean 24yr). Number of training hours 1-30/wk. Mean resting BP was 122 mmHg systolic and 73.5 mmHg diastolic. Mean resting heart rate was 61.7 bpm on ECG. Mean BP responses to maximal exertion in different classes of sports (mmHg) are in table. Conclusion: this is the first study that demonstrates different BP responses associated with different classes of sports. The highest systolic and diastolic BP responses were recorded in moderate static-low dynamic sports. The lowest diastolic BP responses were recorded in moderate static-high dynamic sports. Values above the criteria for hypertension on exertion were in moderate static-low dynamic and high static-low dynamic classes of sports. Further studies are warranted to define ‘‘normal’’ blood pressure response to exercise in different classes of sports
{"title":"Poster Session III: Sports cardiology","authors":"Nicole MPanhuyzen-Goedkoop, R. Terink, Jlrm Smeets, A. Kassim, KA Treusch, A. Fruend, C. Beller, M. Vlachojannis, K. Erdsiek, F. Van, Buuren, K.-P. Mellwig","doi":"10.1177/17418267100170s226","DOIUrl":"https://doi.org/10.1177/17418267100170s226","url":null,"abstract":"P398 Blood pressure response to exercise in young athletes associated with classification of sports N M Nicole MPanhuyzen-Goedkoop, R Terink, JLRM Smeets Radboud University Nijmegen Medical Centre, Heartlung Centre, Nijmegen, Netherlands, Sports Medical Center Papendal, Arnhem, Netherlands Topic: Sports cardiology Purpose: hemodynamic responses to maximal exercise testing cover the general population. Bloodpressure (BP) responses in athletes are reported at rest and during ambulatory BP monitoring. BP responses associated with different classes of sports are lacking. Purpose: To determine BP responses to exercise related to different classes of sports in young athletes (=35yr). Methods: Young athletes who had pre-participation cardiovascular screening, maximal exerciseECG, and were engaged in regular physical training and competition > previous 6 month were included in this retrospective study during 2000-2008. Bicycle exercise protocol until exertion, 75 watt (men) or 50 watt (women) during 4min, increment 25 watt / 2 min. BP and ECG at rest, each increment, and recovery phase was measured manually. Results: 475 athletes were included, 308 men and 167 women, age 9-35yr (mean 24yr). Number of training hours 1-30/wk. Mean resting BP was 122 mmHg systolic and 73.5 mmHg diastolic. Mean resting heart rate was 61.7 bpm on ECG. Mean BP responses to maximal exertion in different classes of sports (mmHg) are in table. Conclusion: this is the first study that demonstrates different BP responses associated with different classes of sports. The highest systolic and diastolic BP responses were recorded in moderate static-low dynamic sports. The lowest diastolic BP responses were recorded in moderate static-high dynamic sports. Values above the criteria for hypertension on exertion were in moderate static-low dynamic and high static-low dynamic classes of sports. Further studies are warranted to define ‘‘normal’’ blood pressure response to exercise in different classes of sports","PeriodicalId":50492,"journal":{"name":"European Journal of Cardiovascular Prevention & Rehabilitation","volume":"17 1","pages":"S88 - S88"},"PeriodicalIF":0.0,"publicationDate":"2010-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/17418267100170s226","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"65491543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2010-05-01DOI: 10.1177/17418267100170s205
P85 The effect of high-intensity training on ventilatory efficiency in chronic heart failure MGJ Gademan, J Myers, K Brunner, W Kottman, C Boesch, P Dubach Palo Alto Veterans Affairs Medical Center / Stanford University, Palo Alto, United States of America, Kantosspital, Chur, Switzerland Topic: Cardiovascular rehabilitation Background: The oxygen uptake efficiency slope (OUES) is a relatively new measure of ventilatory efficiency which has prognostic value in chronic heart failure (CHF) patients. The OUES has the advantage that it is independent of exercise capacity achieved. Little is known regarding the effects of exercise training on OUES in CHF. Hypothesis: High-intensity training improves the OUES in patients with CHF. Methods: Fifty CHF patients were randomized to a 2-month high-intensity residential exercise training program (EXTR, N1⁄424) or to a control group (CTRL, N1⁄426). Before and after the study period, maximal cardiopulmonary exercise testing was performed. Peak oxygen uptake (VO2peak), VE/VCO2 slope, OUES, and minute-by-minute lactate responses were measured. Results: Exercise training significantly increased VO2peak (23%), peak minute ventilation (23%), exercise time (29%) andpeakworkload (28%),whereasno improvementswereobserved in controls (p<0.05). These responses also improved at the lactate threshold (VO2peak 44%, minute ventilation 44%, exercise time 71% and workload 69%). The OUES increased by 11% in the EXTR group and 4% in the CTRL group (p1⁄40.46 between groups). However, the within group change in the EXTR group was highly significant (p1⁄40.003). At baseline, EXTR patients had an OUES that was 69% of the predicted value, and this improved to 78% after finishing the program (p within group1⁄40.004). Conversely, no differences were observed in the VE/VCO2 slope. Conclusions: In these relatively healthy CHF patients, high intensity training resulted in marked improvements inVO2peak, exercise time andworkload.Trainingalso improved theOUESbut not the VE/VCO2 slope. Among measures of ventilatory inefficiency, the OUES may respond more favorably to exercise training than the VE/VCO2 slope. Therefore, an improvement in the OUES may be a more achievable outcome from exercise training in relatively healthy CHF patients.
{"title":"Poster Session I: Cardiac rehabilitation and chronic heart failure","authors":"","doi":"10.1177/17418267100170s205","DOIUrl":"https://doi.org/10.1177/17418267100170s205","url":null,"abstract":"P85 The effect of high-intensity training on ventilatory efficiency in chronic heart failure MGJ Gademan, J Myers, K Brunner, W Kottman, C Boesch, P Dubach Palo Alto Veterans Affairs Medical Center / Stanford University, Palo Alto, United States of America, Kantosspital, Chur, Switzerland Topic: Cardiovascular rehabilitation Background: The oxygen uptake efficiency slope (OUES) is a relatively new measure of ventilatory efficiency which has prognostic value in chronic heart failure (CHF) patients. The OUES has the advantage that it is independent of exercise capacity achieved. Little is known regarding the effects of exercise training on OUES in CHF. Hypothesis: High-intensity training improves the OUES in patients with CHF. Methods: Fifty CHF patients were randomized to a 2-month high-intensity residential exercise training program (EXTR, N1⁄424) or to a control group (CTRL, N1⁄426). Before and after the study period, maximal cardiopulmonary exercise testing was performed. Peak oxygen uptake (VO2peak), VE/VCO2 slope, OUES, and minute-by-minute lactate responses were measured. Results: Exercise training significantly increased VO2peak (23%), peak minute ventilation (23%), exercise time (29%) andpeakworkload (28%),whereasno improvementswereobserved in controls (p<0.05). These responses also improved at the lactate threshold (VO2peak 44%, minute ventilation 44%, exercise time 71% and workload 69%). The OUES increased by 11% in the EXTR group and 4% in the CTRL group (p1⁄40.46 between groups). However, the within group change in the EXTR group was highly significant (p1⁄40.003). At baseline, EXTR patients had an OUES that was 69% of the predicted value, and this improved to 78% after finishing the program (p within group1⁄40.004). Conversely, no differences were observed in the VE/VCO2 slope. Conclusions: In these relatively healthy CHF patients, high intensity training resulted in marked improvements inVO2peak, exercise time andworkload.Trainingalso improved theOUESbut not the VE/VCO2 slope. Among measures of ventilatory inefficiency, the OUES may respond more favorably to exercise training than the VE/VCO2 slope. Therefore, an improvement in the OUES may be a more achievable outcome from exercise training in relatively healthy CHF patients.","PeriodicalId":50492,"journal":{"name":"European Journal of Cardiovascular Prevention & Rehabilitation","volume":"17 1","pages":"S19 - S23"},"PeriodicalIF":0.0,"publicationDate":"2010-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/17418267100170s205","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"65491135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2010-05-01DOI: 10.1177/17418267100170s219
V. Dao, M. Oppermann, N. Mangner, G. Schuler, M. Thomis, S. Onkelinx, JJ Prompers, B. Wessels, W. D. Vries, M.L. Zonderland, Nicolay, G. Schep, P. Doevendans
301 Sustained Hypertension Despite Endothelium-Specific Reintroduction of Functionally Active eNOS in eNOS-Deficient Mice T Suvorava, VT Dao, M Oppermann, G Kojda Institute of Pharmacology and Clinical Pharmacology, University Hospital, Duesseldorf, Germany Topic: Hypertension Purpose: Several studies have shown that eNOS-deficient mice (eNOS-/-) have higher blood pressure than wild-type mice. It is frequently assumed that hypertension in eNOS-/is caused by the lack of endothelium-derived nitric oxide and the resulting increase in arterial tone and peripheral resistance. We sought to investigate whether endothelial-specific targeting of eNOS introduced in eNOS-/can normalize aortic reactivity and blood pressure. Methods:Transgenic mice carrying bovine eNOS (eNOSbovþ) have been generated on C57Bl/ 6 background using the endothelium-specific Tie-2 promotor. By breeding these mice with eNOS knockouts (eNOS-/-), mice that only express eNOSbov (eNOS-/-/eNOSbovþ) were obtained. Results: Western blot analysis confirmed eNOS protein expression in aorta (67.7 12.6), myocardium (49.9 5.4), lung (124.5 2.5) and skeletal muscle (87.0 25.1) of eNOS-/-/ eNOSbovþ as compared to C57Bl/6 (100%, n1⁄43-6). Aortas of eNOS-/-/eNOSbovþ showed complete restoration of endothelium-dependent relaxation to acetylcholine. The doseresponse-patterns to acetylcholine did not differ significantly (P1⁄40.562, n1⁄47-11, two-way ANOVA), and the maximal relaxations were similar in eNOS-/-/eNOSbovþ (98.3 2.14 %, n1⁄47) and C57Bl/6 mice (92.4 3.6 %, n1⁄411) while no relaxation was observed in eNOS-/(137.5 12.1, n1⁄411). Hypersensitivity to phenylephrine observed in eNOS-/mice (maximal contraction 15.2 0.7 mN, n1⁄46, P<0.0001) vs C57Bl/6 (4.6 1.1mN, n1⁄45) was blunted by endothelium-targeted reintroduction of eNOS (2.9 0.8, mN, n1⁄46). Likewise, there was a significant increase in aortic sensitivity to NO-donors S-nitroso-N-acetyl-penicillamine and diethylamine/NO in eNOS-/as compared to C57Bl/6 (n1⁄44-5, P<0.05) and this was completely abolished in eNOS-/-/eNOSbovþ (n1⁄44-5, P1⁄4 0.0278). The expression of both sGC-alpha1 and sGC-beta1 did not reveal any significant difference between eNOS-/-, eNOS-/-/eNOSbovþ and C57Bl/6 (n1⁄44, each P>0.05, ANOVA). Despite complete restoration of aortic reactivity, eNOS-/-/eNOSbovþ mice have strongly elevated systolic blood pressure (n1⁄4137.1 2.26 mmHg, n1⁄48) as compared to C57Bl/6 (118.4 3.1 mmHg, n1⁄46, P<0.05), but not to eNOS-/(135.9 2.07, n1⁄48, P1⁄40.7). Conclusions: Endothelium-specific reintroduction of functionally active eNOS in eNOSdeficient mice resulted in complete normalization of aortic reactivity but not blood pressure. These data suggest that eNOS appears to have limited effect on systemic blood pressure.
{"title":"Oral Abstract Session: Translational science","authors":"V. Dao, M. Oppermann, N. Mangner, G. Schuler, M. Thomis, S. Onkelinx, JJ Prompers, B. Wessels, W. D. Vries, M.L. Zonderland, Nicolay, G. Schep, P. Doevendans","doi":"10.1177/17418267100170s219","DOIUrl":"https://doi.org/10.1177/17418267100170s219","url":null,"abstract":"301 Sustained Hypertension Despite Endothelium-Specific Reintroduction of Functionally Active eNOS in eNOS-Deficient Mice T Suvorava, VT Dao, M Oppermann, G Kojda Institute of Pharmacology and Clinical Pharmacology, University Hospital, Duesseldorf, Germany Topic: Hypertension Purpose: Several studies have shown that eNOS-deficient mice (eNOS-/-) have higher blood pressure than wild-type mice. It is frequently assumed that hypertension in eNOS-/is caused by the lack of endothelium-derived nitric oxide and the resulting increase in arterial tone and peripheral resistance. We sought to investigate whether endothelial-specific targeting of eNOS introduced in eNOS-/can normalize aortic reactivity and blood pressure. Methods:Transgenic mice carrying bovine eNOS (eNOSbovþ) have been generated on C57Bl/ 6 background using the endothelium-specific Tie-2 promotor. By breeding these mice with eNOS knockouts (eNOS-/-), mice that only express eNOSbov (eNOS-/-/eNOSbovþ) were obtained. Results: Western blot analysis confirmed eNOS protein expression in aorta (67.7 12.6), myocardium (49.9 5.4), lung (124.5 2.5) and skeletal muscle (87.0 25.1) of eNOS-/-/ eNOSbovþ as compared to C57Bl/6 (100%, n1⁄43-6). Aortas of eNOS-/-/eNOSbovþ showed complete restoration of endothelium-dependent relaxation to acetylcholine. The doseresponse-patterns to acetylcholine did not differ significantly (P1⁄40.562, n1⁄47-11, two-way ANOVA), and the maximal relaxations were similar in eNOS-/-/eNOSbovþ (98.3 2.14 %, n1⁄47) and C57Bl/6 mice (92.4 3.6 %, n1⁄411) while no relaxation was observed in eNOS-/(137.5 12.1, n1⁄411). Hypersensitivity to phenylephrine observed in eNOS-/mice (maximal contraction 15.2 0.7 mN, n1⁄46, P<0.0001) vs C57Bl/6 (4.6 1.1mN, n1⁄45) was blunted by endothelium-targeted reintroduction of eNOS (2.9 0.8, mN, n1⁄46). Likewise, there was a significant increase in aortic sensitivity to NO-donors S-nitroso-N-acetyl-penicillamine and diethylamine/NO in eNOS-/as compared to C57Bl/6 (n1⁄44-5, P<0.05) and this was completely abolished in eNOS-/-/eNOSbovþ (n1⁄44-5, P1⁄4 0.0278). The expression of both sGC-alpha1 and sGC-beta1 did not reveal any significant difference between eNOS-/-, eNOS-/-/eNOSbovþ and C57Bl/6 (n1⁄44, each P>0.05, ANOVA). Despite complete restoration of aortic reactivity, eNOS-/-/eNOSbovþ mice have strongly elevated systolic blood pressure (n1⁄4137.1 2.26 mmHg, n1⁄48) as compared to C57Bl/6 (118.4 3.1 mmHg, n1⁄46, P<0.05), but not to eNOS-/(135.9 2.07, n1⁄48, P1⁄40.7). Conclusions: Endothelium-specific reintroduction of functionally active eNOS in eNOSdeficient mice resulted in complete normalization of aortic reactivity but not blood pressure. These data suggest that eNOS appears to have limited effect on systemic blood pressure.","PeriodicalId":50492,"journal":{"name":"European Journal of Cardiovascular Prevention & Rehabilitation","volume":"17 1","pages":"S61 - S62"},"PeriodicalIF":0.0,"publicationDate":"2010-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/17418267100170s219","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"65491320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2010-05-01DOI: 10.1177/17418267100170s230
Y. Chan, C. Siu, K. Yiu, Sw Li, S. Tam, Th Lam, C. Lau, H. Tse, N. Smeeton, S. Allender, S. Yamada, K. Kamisaka, A. Araki, Y. Fujioka, K. Yasui, Y. Hasegawa, Koike
P475 Secondary prevention of stroke in Czech patients in the EUROASPIRE III Study Stroke Specific Module J Bruthans, O Mayer, J Simon, M Galovcova, J Hrbkova, J Belohoubek, R Cifkova, H Rosolova Institute for Clinical and Experimental Medicine, Prague, Czech Republic, Charles University School of Medicine, Pilsen, Czech Republic Topic: Stroke Aims of study: To assess the prevalence of major risk factors for ischemic stroke, to determine implementation of the secondary prevention of stroke in clinical practice. Methods: A total of 507 consecutive patients aged < 80 years and hospitalized for their first ischemic stroke in the respective district hospital (Praha 4 and Plzen-mesto) were selected retrospectively. Data were obtained from patients hospital medical records and subsequent patients history including the completion of structured questionnaires. Outpatient examination including fasting blood sampling was performed at 636 months post-stroke. The survey was carried out as part of a European study using the protocol of the EUROASPIRE III study Stroke Specific Module. Results: A total of 341 men and women were examined. Of these, at the time of examination, 636 months post stroke, 14.9% were current smokers, 38.8% were obese, 81% had blood pressure levels> 130/80 mmHg, 71.1% had increased LDL-cholesterol (> 2.5 mmol/L), 32.3% had overt diabetes (fasting blood glucose > 7 mmol/L or treatment with oral hypoglycemic agents or insulin), with only 5.5% of patients with diabetes showing satisfactory diabetes control (fasting blood glucose< 6.1 mmol/L). At the time of this examination, 78.9% of patients were receiving antiplatelet drugs or anticoagulants, 52.2% statins, 85.9% antihypertensive medication (43.1% beta-blockers, 68.9% ACE inhibitors or angiotensin II receptor blockers, 39.9% diuretics, and 32.6% calcium-channel blockers). Only a small proportion of patients were compliant with nonpharmacologic measures of secondary prevention (exercise and diet in particular). While signs of depression were possibly or likely present in 33.3% of patients, 21% of patients showed likely or probable anxiety. Conclusion: Secondary preventive lifestyle measures are inadequately implemented, with only a small proportion of patients achieving goal values of risk factors despite widely used drug therapy. The role of post-stroke rehabilitation and psychotherapy is largely underestimated.
J Bruthans, O Mayer, J Simon, M Galovcova, J Hrbkova, J Belohoubek, R Cifkova, H Rosolova临床和实验医学研究所，布拉格，捷克共和国，查尔斯大学医学院，皮尔森，捷克共和国主题:卒中研究目的:评估缺血性脑卒中主要危险因素的患病率，确定临床实践中脑卒中二级预防的实施情况。方法:回顾性分析在Praha 4区医院和Plzen-mesto区医院连续住院的507例年龄< 80岁的首次缺血性脑卒中患者。数据来自患者的医院医疗记录和随后的患者病史，包括完成结构化问卷。中风后636个月进行门诊检查，包括空腹采血。该调查是一项欧洲研究的一部分，使用EUROASPIRE III研究卒中特定模块的协议。结果:共检查了341名男性和女性。其中，在检查时，中风后636个月，14.9%为吸烟者，38.8%为肥胖，81%血压水平为>30 /80 mmHg, 71.1%低密度脂蛋白胆固醇升高(> 2.5 mmol/L)， 32.3%有明显的糖尿病(空腹血糖> 7 mmol/L或口服降糖药或胰岛素治疗)，只有5.5%的糖尿病患者表现出满意的糖尿病控制(空腹血糖< 6.1 mmol/L)。在本次检查时，78.9%的患者正在接受抗血小板药物或抗凝血药物，52.2%的他汀类药物，85.9%的抗高血压药物(43.1%的受体阻滞剂，68.9%的ACE抑制剂或血管紧张素II受体阻滞剂，39.9%的利尿剂和32.6%的钙通道阻滞剂)。只有一小部分患者接受了非药物的二级预防措施(尤其是运动和饮食)。33.3%的患者可能或可能出现抑郁症状，21%的患者可能或可能表现出焦虑。结论:二级预防生活方式措施实施不充分，尽管广泛使用药物治疗，但只有一小部分患者达到危险因素目标值。中风后康复和心理治疗的作用在很大程度上被低估了。
{"title":"Poster Session IV. Epidemiology and public health","authors":"Y. Chan, C. Siu, K. Yiu, Sw Li, S. Tam, Th Lam, C. Lau, H. Tse, N. Smeeton, S. Allender, S. Yamada, K. Kamisaka, A. Araki, Y. Fujioka, K. Yasui, Y. Hasegawa, Koike","doi":"10.1177/17418267100170s230","DOIUrl":"https://doi.org/10.1177/17418267100170s230","url":null,"abstract":"P475 Secondary prevention of stroke in Czech patients in the EUROASPIRE III Study Stroke Specific Module J Bruthans, O Mayer, J Simon, M Galovcova, J Hrbkova, J Belohoubek, R Cifkova, H Rosolova Institute for Clinical and Experimental Medicine, Prague, Czech Republic, Charles University School of Medicine, Pilsen, Czech Republic Topic: Stroke Aims of study: To assess the prevalence of major risk factors for ischemic stroke, to determine implementation of the secondary prevention of stroke in clinical practice. Methods: A total of 507 consecutive patients aged < 80 years and hospitalized for their first ischemic stroke in the respective district hospital (Praha 4 and Plzen-mesto) were selected retrospectively. Data were obtained from patients hospital medical records and subsequent patients history including the completion of structured questionnaires. Outpatient examination including fasting blood sampling was performed at 636 months post-stroke. The survey was carried out as part of a European study using the protocol of the EUROASPIRE III study Stroke Specific Module. Results: A total of 341 men and women were examined. Of these, at the time of examination, 636 months post stroke, 14.9% were current smokers, 38.8% were obese, 81% had blood pressure levels> 130/80 mmHg, 71.1% had increased LDL-cholesterol (> 2.5 mmol/L), 32.3% had overt diabetes (fasting blood glucose > 7 mmol/L or treatment with oral hypoglycemic agents or insulin), with only 5.5% of patients with diabetes showing satisfactory diabetes control (fasting blood glucose< 6.1 mmol/L). At the time of this examination, 78.9% of patients were receiving antiplatelet drugs or anticoagulants, 52.2% statins, 85.9% antihypertensive medication (43.1% beta-blockers, 68.9% ACE inhibitors or angiotensin II receptor blockers, 39.9% diuretics, and 32.6% calcium-channel blockers). Only a small proportion of patients were compliant with nonpharmacologic measures of secondary prevention (exercise and diet in particular). While signs of depression were possibly or likely present in 33.3% of patients, 21% of patients showed likely or probable anxiety. Conclusion: Secondary preventive lifestyle measures are inadequately implemented, with only a small proportion of patients achieving goal values of risk factors despite widely used drug therapy. The role of post-stroke rehabilitation and psychotherapy is largely underestimated.","PeriodicalId":50492,"journal":{"name":"European Journal of Cardiovascular Prevention & Rehabilitation","volume":"17 1","pages":"S105 - S98"},"PeriodicalIF":0.0,"publicationDate":"2010-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/17418267100170s230","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"65491707","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2010-05-01DOI: 10.1177/17418267100170s212
JS Mindell, P. Zaninotto, E. Falaschetti, M. Aresu, N. Poulter, G. Flores-Mateo, M. O’flaherty, K. Nnoaham, F. Lloyd-Williams, M. Rayner, Capewell, S. GWannamethee, L. T. Lennon, M. C. Thomas, P. HWhincup, G. Kopec, B. Sobien, M. Podolec, H. Dziedzic, M. Sobien, M. Brozda, A. Pajak, Podolec
P190 The Italian Health Examination Survey: time trends of CVD risk factors S Giampaoli, C Lo Noce, L Iacoviello, D Vanuzzo, L Palmieri, C Donfrancesco, J Stamler Instituto Superiore di Sanita, Rome, Italy, Catholic University of the Sacred Heart, Campobasso, Italy, Center for Cardiovascular Prevention, Udine, Italy, Northwestern University, Feinberg School of Medicine, Chicago, United States of America Topic: Risk factors and risk prediction Purpose: A periodic Health Examination Survey (HES)-Osservatorio Epidemiologico Cardiovascolare (OEC) has been implemented in Italy. The aim of this analysis is to present initial results for 2008-09 and compare them with those collected in 1998, the previous HES. Methods: Randomized population samples stratified by age and sex were examined (participation rate 63%). Risk factor data were collected using MONICA Project standardized methodologies; biochemical levels were assayed in a central laboratory. In 1998, about 10,000 men and women ages 35-74 years were enrolled throughout the country (200 persons from each 1,5 million of resident population). The new screening is enrolling the same sample size, age range 35-79 years. All data are age-standardized using the European standard population. Results: Data here are from 7 regions, for a total of 1,454 men and women in 1998 and 1,864 persons in 2008-09. Data comparison shows a decrease for systolic blood pressure (men: from 139 to 135 mmHg; women: from 130 to 125 mmHg) and diastolic blood pressure (men: from 87 to 82 mmHg; women: from 82 to 78 mmHg); an increase for serum total cholesterol (men: from 209 to 217 mg/dl; women: from 206 to 218 mg/dl), while HDL-cholesterol remained stable (men: 52 and 51 mg/dl; women: 59 and 60 mg/dl); body mass index also was stable for men and women (average 28 kg/m2 and 27 kg/m2); glycemia increased in both genders (men: from 92 to 97mg/dl; women: from 87 to 89 mg/dl). Prevalence of obesity increased from 21% to 26% in men, and did not change in women (26%); prevalence of diabetes did not change in men (12%) and decreased slightly in women (from 8% to 7%); smoking habit decreased in men (from 33% to 26%) but not in women (22% in both surveys). Conclusions: Although these are only preliminary results, HES trends show troublesome increases in total cholesterol, glycemia, and obesity; improvements in blood pressure. In combination with other information sources, the OEC can contribute greatly to evaluation of the efficacy of community actions (the Italian smoking ban regulation, introduction of risk assessment in clinical practice) and to elaboration of needed next efforts.
P190意大利健康检查调查:心血管疾病危险因素的时间趋势S Giampaoli, C Lo Noce, L Iacoviello, D Vanuzzo, L Palmieri, C Donfrancesco，意大利罗马Stamler高等卫生研究所，意大利坎波巴索天主教圣心大学，意大利乌迪内心血管预防中心，美国芝加哥西北大学Feinberg医学院意大利实施了定期健康检查调查——心血管流行病学观察(OEC)。这一分析的目的是提出2008-09年的初步结果，并将其与1998年的统计数据进行比较。方法:按年龄和性别分层随机抽样(参与率63%)。采用MONICA项目标准化方法收集风险因素数据;生化水平在中心实验室检测。1998年，全国约有1万名年龄在35-74岁之间的男女参加了登记(每150万常住人口中有200人参加)。新的筛查纳入了相同的样本量，年龄在35-79岁之间。所有数据均使用欧洲标准人口进行年龄标准化。结果:这里的数据来自7个地区，1998年共有1454名男性和女性，2008-09年共有1864人。数据比较显示收缩压降低(男性:从139 mmHg降至135 mmHg;女性:从130到125 mmHg)和舒张压(男性:从87到82 mmHg;女性:从82到78毫米汞柱);血清总胆固醇升高(男性:从209毫克/分升到217毫克/分升;女性:从206到218毫克/分升)，而高密度脂蛋白胆固醇保持稳定(男性:52和51毫克/分升;女性:59和60毫克/分升);男性和女性的身体质量指数也很稳定(平均28 kg/m2和27 kg/m2);男女血糖均升高(男性:从92毫克/分升到97mg/分升;女性:从87到89毫克/分升)。男性的肥胖患病率从21%上升到26%，而女性没有变化(26%);糖尿病患病率在男性中没有变化(12%)，在女性中略有下降(从8%降至7%);男性吸烟习惯下降(从33%降至26%)，但女性没有下降(两项调查均为22%)。结论:虽然这些只是初步结果，但HES趋势显示总胆固醇、血糖和肥胖的增加令人担忧;改善血压。与其他信息来源相结合，经合组织可以大大有助于评价社区行动的效力(意大利的禁烟条例、在临床实践中采用风险评估)，并有助于拟订今后需要作出的努力。
{"title":"Poster Session II: Epidemiology and public health","authors":"JS Mindell, P. Zaninotto, E. Falaschetti, M. Aresu, N. Poulter, G. Flores-Mateo, M. O’flaherty, K. Nnoaham, F. Lloyd-Williams, M. Rayner, Capewell, S. GWannamethee, L. T. Lennon, M. C. Thomas, P. HWhincup, G. Kopec, B. Sobien, M. Podolec, H. Dziedzic, M. Sobien, M. Brozda, A. Pajak, Podolec","doi":"10.1177/17418267100170s212","DOIUrl":"https://doi.org/10.1177/17418267100170s212","url":null,"abstract":"P190 The Italian Health Examination Survey: time trends of CVD risk factors S Giampaoli, C Lo Noce, L Iacoviello, D Vanuzzo, L Palmieri, C Donfrancesco, J Stamler Instituto Superiore di Sanita, Rome, Italy, Catholic University of the Sacred Heart, Campobasso, Italy, Center for Cardiovascular Prevention, Udine, Italy, Northwestern University, Feinberg School of Medicine, Chicago, United States of America Topic: Risk factors and risk prediction Purpose: A periodic Health Examination Survey (HES)-Osservatorio Epidemiologico Cardiovascolare (OEC) has been implemented in Italy. The aim of this analysis is to present initial results for 2008-09 and compare them with those collected in 1998, the previous HES. Methods: Randomized population samples stratified by age and sex were examined (participation rate 63%). Risk factor data were collected using MONICA Project standardized methodologies; biochemical levels were assayed in a central laboratory. In 1998, about 10,000 men and women ages 35-74 years were enrolled throughout the country (200 persons from each 1,5 million of resident population). The new screening is enrolling the same sample size, age range 35-79 years. All data are age-standardized using the European standard population. Results: Data here are from 7 regions, for a total of 1,454 men and women in 1998 and 1,864 persons in 2008-09. Data comparison shows a decrease for systolic blood pressure (men: from 139 to 135 mmHg; women: from 130 to 125 mmHg) and diastolic blood pressure (men: from 87 to 82 mmHg; women: from 82 to 78 mmHg); an increase for serum total cholesterol (men: from 209 to 217 mg/dl; women: from 206 to 218 mg/dl), while HDL-cholesterol remained stable (men: 52 and 51 mg/dl; women: 59 and 60 mg/dl); body mass index also was stable for men and women (average 28 kg/m2 and 27 kg/m2); glycemia increased in both genders (men: from 92 to 97mg/dl; women: from 87 to 89 mg/dl). Prevalence of obesity increased from 21% to 26% in men, and did not change in women (26%); prevalence of diabetes did not change in men (12%) and decreased slightly in women (from 8% to 7%); smoking habit decreased in men (from 33% to 26%) but not in women (22% in both surveys). Conclusions: Although these are only preliminary results, HES trends show troublesome increases in total cholesterol, glycemia, and obesity; improvements in blood pressure. In combination with other information sources, the OEC can contribute greatly to evaluation of the efficacy of community actions (the Italian smoking ban regulation, introduction of risk assessment in clinical practice) and to elaboration of needed next efforts.","PeriodicalId":50492,"journal":{"name":"European Journal of Cardiovascular Prevention & Rehabilitation","volume":"17 1","pages":"S38 - S46"},"PeriodicalIF":0.0,"publicationDate":"2010-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/17418267100170s212","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"65490884","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2010-05-01DOI: 10.1177/17418267100170s202
K. Ueshima, K. Oba, A. Fujimoto, T. Ogihara, T. Saruta, K. Nakao, F. Farahati
P22 C-reactive protein in prepubertal children with abdominal obesity as a marker of cardiovascular and metabolic risk S Galcheva, Y Yotov, V Iotova Medical University, Varna, Bulgaria Topic: Risk factors and risk prediction High sensitivity C-reactive protein (hsCRP) is a marker of inflammation and is found to be a significant predictor of cardiovascular diseases (CVD). Metabolic syndrome and abdominal obesity are associated with earlier and more severe presentation of atherosclerosis. Aim: To evaluate the level of hsCRP in children aged below 10 years according to overweight/ obesity status and in relation to cardiovascular parameters and other risk factors. Participants and methods:We evaluated 168 healthy children (78 boys and 90 girls) at the mean age 8.1 1.2 years divided in three groups normal (NW, 31.5%), overweight (OW, 27.4%) or obese (OB, 41.1%) according to bodymass index (BMI) international reference (Cole, 2000) and waist circumference (WC). Their blood pressure (BP) and heart rate (HR) were measured and blood tests for fasting blood glucose (BG), immunoreactive insulin (IRI), lipids, liver enzymes, hsCRP, and other proinflammatory and hormonal markers were drawn. HOMA-IR was calculated according to the standard formula. Log transformation of data for the hsCRP, BMI and other variables was performed where appropriate because of skewed distribution. Results: The hsCRP was significantly higher in the OB 7.53 0.91 (mean SE) compared with the OW 4.11 0.9 (p1⁄40.029) and NW 3.17 0.88 mg/l (p1⁄40.001) children, without important gender differences. The inflammation marker displayed significant linear increase with both BMI andWC. The hsCRP was positively correlated with IRI (r1⁄40.237, p1⁄4 0.004), with HOMAIR (r1⁄40.279, p1⁄40.001), with systolic BP (r1⁄40.396, p<0.0001) and diastolic BP (r1⁄40.299, p <0.0001), and negatively with HDL-cholesterol (r1⁄4-0.202, p1⁄40.013). In multivariable linear regression model, the hsCRP increased with 1.84 mg/l (95%CI1⁄41.50-2.26, p<0.0001) per WC quartile after adjustment for age, gender, BMI, birth weight, BG, HOMA-IR. For BMI, the significance of the relation with hsCRP which was present in the univariate analysis disappeared after adjusting for WC in the multivariate model. Conclusions: The hsCRP is elevated in healthy overweight and obese children already in prepuberty. It correlates with higher BP and other important risk factors for CVD. At this age, waist circumference is a better predictor of the hsCRP levels than is BMI. The prevention of CVD through weight control has to start early in life.
{"title":"Moderated Poster Session II: Epidemiology and public health","authors":"K. Ueshima, K. Oba, A. Fujimoto, T. Ogihara, T. Saruta, K. Nakao, F. Farahati","doi":"10.1177/17418267100170s202","DOIUrl":"https://doi.org/10.1177/17418267100170s202","url":null,"abstract":"P22 C-reactive protein in prepubertal children with abdominal obesity as a marker of cardiovascular and metabolic risk S Galcheva, Y Yotov, V Iotova Medical University, Varna, Bulgaria Topic: Risk factors and risk prediction High sensitivity C-reactive protein (hsCRP) is a marker of inflammation and is found to be a significant predictor of cardiovascular diseases (CVD). Metabolic syndrome and abdominal obesity are associated with earlier and more severe presentation of atherosclerosis. Aim: To evaluate the level of hsCRP in children aged below 10 years according to overweight/ obesity status and in relation to cardiovascular parameters and other risk factors. Participants and methods:We evaluated 168 healthy children (78 boys and 90 girls) at the mean age 8.1 1.2 years divided in three groups normal (NW, 31.5%), overweight (OW, 27.4%) or obese (OB, 41.1%) according to bodymass index (BMI) international reference (Cole, 2000) and waist circumference (WC). Their blood pressure (BP) and heart rate (HR) were measured and blood tests for fasting blood glucose (BG), immunoreactive insulin (IRI), lipids, liver enzymes, hsCRP, and other proinflammatory and hormonal markers were drawn. HOMA-IR was calculated according to the standard formula. Log transformation of data for the hsCRP, BMI and other variables was performed where appropriate because of skewed distribution. Results: The hsCRP was significantly higher in the OB 7.53 0.91 (mean SE) compared with the OW 4.11 0.9 (p1⁄40.029) and NW 3.17 0.88 mg/l (p1⁄40.001) children, without important gender differences. The inflammation marker displayed significant linear increase with both BMI andWC. The hsCRP was positively correlated with IRI (r1⁄40.237, p1⁄4 0.004), with HOMAIR (r1⁄40.279, p1⁄40.001), with systolic BP (r1⁄40.396, p<0.0001) and diastolic BP (r1⁄40.299, p <0.0001), and negatively with HDL-cholesterol (r1⁄4-0.202, p1⁄40.013). In multivariable linear regression model, the hsCRP increased with 1.84 mg/l (95%CI1⁄41.50-2.26, p<0.0001) per WC quartile after adjustment for age, gender, BMI, birth weight, BG, HOMA-IR. For BMI, the significance of the relation with hsCRP which was present in the univariate analysis disappeared after adjusting for WC in the multivariate model. Conclusions: The hsCRP is elevated in healthy overweight and obese children already in prepuberty. It correlates with higher BP and other important risk factors for CVD. At this age, waist circumference is a better predictor of the hsCRP levels than is BMI. The prevention of CVD through weight control has to start early in life.","PeriodicalId":50492,"journal":{"name":"European Journal of Cardiovascular Prevention & Rehabilitation","volume":"17 1","pages":"S3 - S4"},"PeriodicalIF":0.0,"publicationDate":"2010-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/17418267100170s202","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"65491084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2010-05-01DOI: 10.1177/17418267100170s222
F. Cesari, R. Marcucci, F. Sofi, C. Burgisser, S. Luly, R. Abbate, G. Gensini, Fattirolli
P316 Endothelial progenitor cells mobilization and inflammation after cardiac rehabilitation on patients undergoing percutaneous coronary intervention after acute coronary sindrome F Cesari, R Marcucci, F Sofi, C Burgisser, S Luly, R Abbate, GF Gensini, F Fattirolli Department of Medical and Surgical Critical Care, Thrombosis Centre, University of Florence, Florence, Italy, Cardiac Rehabilitation Center , Unit of Gerontology and Geriatrics , University of Florence, Florence, Italy Topic: Cardiovascular rehabilitation Background: Endothelial progenitor cells (EPCs) are bone marrow-derived progenitor cells which support vascular endothelium, so playing a crucial role in the beginning and progression of atherosclerosis. It has been previously demonstrated that a potent trigger for EPCs mobilization is regular physical exercise. However, few data regarding the possible effect of cardiac rehabilitation (CR) program after primary percutaneous coronary intervention (PCI) on EPCs are available. We performed this study in order to assess the variations of EPCs in relation to inflammatory markers in patients who performed a four weeks CR after PCI. Methods: 55 patients [45 M/10 F; mean age 58 (41-74) years] were admitted in an four weeks execise-based CR program after acute coronary syndrome and PCI. The numbers of EPCs and the sera levels of NT-ProBNP and high sensitivity C-reactive protein (CRP) were determined at the beginning (T1) and at the end (T2) of the CR program. All patients were under HMG-CoA reductase inhibitor therapy and performed a cardiopulmonary exercise test at T1 and at T2. Peripheral blood EPCs were measured by using flow cytometry and were defined as CD34þKDRþ, CD133þKDRþ and CD34þCD133þKDRþ. CRP and NT-ProBNP were measured by using a nephelometric and an immunometric method, respectively. Results: With regards to EPCs, we observed a significantly increase at T2 with respect to T1 [CD34þKDRþ: 7 (0-27) vs. 13 (0-37) cells/106 events p1⁄40.010; CD133þKDRþ: 7(0-27 vs. 10 (0-33) ) cells/106 events p1⁄40.018; CD34þCD133þKDRþ: 7 (0-27) vs. 10 (0-33) cells/106 events p1⁄40.014]. As expected, a significantly increase at T2 was observed for cardiopulmonary parameters (VO2max andWatt) whereas hsCRP andNT-ProBNP levels significantly decreased at T2 with respect to T1 values. By diving our patients populations in relation to the increase of EPCs, patients with an increase of EPCs were significantly younger with respect to the others [56 (42-74) vs. 61 (41-74) p<0.05], showed significantly lower baseline levels of CRP [2.5 (0.4-9.0) vs. 6.3 (0.3-9.1) mg/L p<0.05] and a better exercise tolerance with higher basal VO2max [21.0 (10.0-30.7) vs. 17.9 (10.0-28.0) ml/Kg/min]. Moreover, among cardiovascular risk factors the presence of smoking habit and obesity negatively influenced the increase of EPCs. Conclusion: A four weeks exercise-based CR program after ACS and PCI, is able to determine an increase of EPCs number with a contemporary decrease of CRP
P316急性冠状动脉综合征经皮冠状动脉介入治疗患者心脏康复后内皮祖细胞的动员和炎症F Cesari, R Marcucci, F Sofi, C Burgisser, S Luly, R Abbate, GF Gensini, F Fattirolli意大利佛罗伦萨佛罗伦萨大学内科和外科重症监护中心血栓形成中心，佛罗伦萨佛罗伦萨大学老年医学和老年医学单元心脏康复中心，意大利佛罗伦萨背景:内皮祖细胞(Endothelial progenitor cells, EPCs)是支持血管内皮的骨髓源性祖细胞，在动脉粥样硬化的发生和发展中起着至关重要的作用。以前已经证明，有规律的体育锻炼是EPCs动员的有效触发因素。然而，关于经皮冠状动脉介入治疗(PCI)后心脏康复(CR)计划对EPCs可能产生的影响的数据很少。我们进行这项研究是为了评估在PCI术后进行4周CR的患者中EPCs与炎症标志物的变化。方法:55例患者[45 M/10 F;平均年龄58(41-74)岁)，在急性冠状动脉综合征和PCI术后接受为期四周的运动CR治疗。在CR项目开始(T1)和结束(T2)时测定EPCs数量、NT-ProBNP和高敏c反应蛋白(CRP)水平。所有患者均接受HMG-CoA还原酶抑制剂治疗，并在T1和T2进行心肺运动试验。采用流式细胞术检测外周血EPCs，定义为cd34 ~ kdr þ、cd133 ~ kdr þ和cd34 ~ cd133 ~ kdr þ。CRP和NT-ProBNP分别采用浊度法和免疫法测定。结果:关于EPCs，我们观察到T2时EPCs相对于T1显著增加[CD34þKDRþ: 7 (0-27) vs 13(0-37)个细胞/106事件p1 / 40.010;cd133 - þ: 7(0-27 vs. 10(0-33))个细胞/106个事件p1 / 40.018;cd34 - þ cd133 - þ: 7 (0-27) vs. 10 (0-33) cells/106 events [p1 / 40.014]。正如预期的那样，在T2时观察到心肺参数(VO2max和watt)显着增加，而hsCRP和nt - probnp水平在T2时相对于T1值显着降低。通过对EPCs升高的患者群体进行分析，EPCs升高的患者明显比其他患者年轻[56 (42-74)vs. 61 (41-74) p<0.05]， CRP基线水平显著降低[2.5 (0.4-9.0)vs. 6.3 (0.3-9.1) mg/L p<0.05]，运动耐受性更好，基础VO2max更高[21.0 (10.0-30.7)vs. 17.9 (10.0-28.0) ml/Kg/min]。此外，在心血管危险因素中，吸烟习惯和肥胖的存在对EPCs的增加有负面影响。结论:在ACS和PCI术后进行为期四周的运动CR计划，能够确定EPCs数量的增加与CRP和NT-ProBNP的同时降低。然而，在年龄、肥胖、吸烟习惯、CRP水平和运动耐受性方面，EPCs的行为不同。
{"title":"Moderated Poster Session VI: Cardiac rehabilitation","authors":"F. Cesari, R. Marcucci, F. Sofi, C. Burgisser, S. Luly, R. Abbate, G. Gensini, Fattirolli","doi":"10.1177/17418267100170s222","DOIUrl":"https://doi.org/10.1177/17418267100170s222","url":null,"abstract":"P316 Endothelial progenitor cells mobilization and inflammation after cardiac rehabilitation on patients undergoing percutaneous coronary intervention after acute coronary sindrome F Cesari, R Marcucci, F Sofi, C Burgisser, S Luly, R Abbate, GF Gensini, F Fattirolli Department of Medical and Surgical Critical Care, Thrombosis Centre, University of Florence, Florence, Italy, Cardiac Rehabilitation Center , Unit of Gerontology and Geriatrics , University of Florence, Florence, Italy Topic: Cardiovascular rehabilitation Background: Endothelial progenitor cells (EPCs) are bone marrow-derived progenitor cells which support vascular endothelium, so playing a crucial role in the beginning and progression of atherosclerosis. It has been previously demonstrated that a potent trigger for EPCs mobilization is regular physical exercise. However, few data regarding the possible effect of cardiac rehabilitation (CR) program after primary percutaneous coronary intervention (PCI) on EPCs are available. We performed this study in order to assess the variations of EPCs in relation to inflammatory markers in patients who performed a four weeks CR after PCI. Methods: 55 patients [45 M/10 F; mean age 58 (41-74) years] were admitted in an four weeks execise-based CR program after acute coronary syndrome and PCI. The numbers of EPCs and the sera levels of NT-ProBNP and high sensitivity C-reactive protein (CRP) were determined at the beginning (T1) and at the end (T2) of the CR program. All patients were under HMG-CoA reductase inhibitor therapy and performed a cardiopulmonary exercise test at T1 and at T2. Peripheral blood EPCs were measured by using flow cytometry and were defined as CD34þKDRþ, CD133þKDRþ and CD34þCD133þKDRþ. CRP and NT-ProBNP were measured by using a nephelometric and an immunometric method, respectively. Results: With regards to EPCs, we observed a significantly increase at T2 with respect to T1 [CD34þKDRþ: 7 (0-27) vs. 13 (0-37) cells/106 events p1⁄40.010; CD133þKDRþ: 7(0-27 vs. 10 (0-33) ) cells/106 events p1⁄40.018; CD34þCD133þKDRþ: 7 (0-27) vs. 10 (0-33) cells/106 events p1⁄40.014]. As expected, a significantly increase at T2 was observed for cardiopulmonary parameters (VO2max andWatt) whereas hsCRP andNT-ProBNP levels significantly decreased at T2 with respect to T1 values. By diving our patients populations in relation to the increase of EPCs, patients with an increase of EPCs were significantly younger with respect to the others [56 (42-74) vs. 61 (41-74) p<0.05], showed significantly lower baseline levels of CRP [2.5 (0.4-9.0) vs. 6.3 (0.3-9.1) mg/L p<0.05] and a better exercise tolerance with higher basal VO2max [21.0 (10.0-30.7) vs. 17.9 (10.0-28.0) ml/Kg/min]. Moreover, among cardiovascular risk factors the presence of smoking habit and obesity negatively influenced the increase of EPCs. Conclusion: A four weeks exercise-based CR program after ACS and PCI, is able to determine an increase of EPCs number with a contemporary decrease of CRP","PeriodicalId":50492,"journal":{"name":"European Journal of Cardiovascular Prevention & Rehabilitation","volume":"17 1","pages":"S67 - S68"},"PeriodicalIF":0.0,"publicationDate":"2010-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/17418267100170s222","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"65491439","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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