Electromagnetic Biology and Medicine最新文献

The advantages of Magnetic Coupling Resonant Wireless Power Transfer (MCR-WPT) technology include long transmission distance, high efficiency, and high power. Therefore, it shows great potential in the field of smart home. This study aims to explore the specific impacts on the cognitive functions and neuronal excitation of mice exposed to the electromagnetic fields (EMF) emitted by the MCR-WPT platform, thereby providing biological solid experimental evidence for developing Wireless Power Transfer (WPT) technology. The research employed a frequency of 90 kHz, which is suitable for wireless charging of household appliances. Mice were exposed to EMF emitted by the WPT biosafety experimental platform for various durations. And they were divided into four groups (control group, 2-week exposure group, 4-week exposure group, and 8-week exposure group). Upon completion of the exposure period, the study employed the Novel Object Recognition (NOR) test to evaluate the learning and memory capabilities of the animals. Following this, whole-cell patch-clamp experiments were conducted to record the action potentials (AP) and potassium currents. It was revealed by our observations that, in comparison to mice without electromagnetic exposure, long-term exposure to WPT-emitted EMF resulted in accelerated release of action potentials, inhibited the activation of Voltage-Gated Potassium Channels (VGKCs) current, accelerated the deactivation of K⁺ channel current, and thus significantly improved the excitability of neurons in the dentate gyrus (DG) of the hippocampus of mice, but did not significantly affect cognitive function.

Biomagnetic fluid dynamics (BFD) is an emerging and promising field within fluid mechanics, focusing on the dynamics of bio-fluids like blood in the presence of magnetic fields. This research is crucial in the medical arena for applications such as medication delivery, diagnostic and therapeutic procedures, prevention of excessive bleeding, and treatment of malignant tumors using magnetic particles. This study delves into the intricacies of blood flow induced by cilia, carrying trihybrid nanoparticles (gold, copper, and titania), within a catheterized arterial annulus under a robust magnetic field. The model incorporates factors like Hall and ion-slip currents (electromagnetic effects on charged particles), metachronal propulsion (movement of cilia for propulsion), viscous dissipation, and entropy. The physical equations in the model are transformed from the laboratory frame to a wave frame and then simplified using conditions like low Reynolds number and long wavelength. Optimal series solutions are obtained through the homotopy perturbation method (HPM). The research explores how various physical parameters shape the bloodstream's features, presenting and analyzing these visually. A notable finding is that an intensification in Hall and ion-slip parameters results in higher blood velocity within the catheterized annulus. Blood cooling is observed with a higher loading of suspended nanoparticles. Entropy generation increases with growing values of Hall and ion-slip parameters, while the reverse trend is noted for the Bejan number. The wall shearing stress (WSS) reduces by 2.84% for 1% increase in Hall parameter. The study also provides a brief overview of how blood boluses (or clumps of blood) are structured under the influence of operating parameters. The modified hybrid nano-blood (MHNB) forms smaller and fewer boluses compared to pure blood (PB). Additionally, longer cilia length results in enhanced trapping of boluses due to stronger recovery motions of the cilia. This research holds potential benefits for practitioners and researchers in diagnosing and assessing conditions such as coronary artery disease, valvular heart disease, and congenital heart abnormalities, as well as for understanding traumatic brain injury and neurological surgeries.

Epidemiological studies have found an association between occupational exposure to low frequency magnetic fields and the occurrence of motor neuron disease and Alzheimer's disease. No association has been found for Parkinson's disease and the evidence for multiple sclerosis is insufficient. Animal models studying the effects of low frequency magnetic fields on neurodegenerative disease induction or progression could provide more evidence on causation and the underlying mechanisms. A systematic search and review was conducted of peer-reviewed research articles involving animal experiments on the effects of low frequency magnetic field exposure on behavioural and neuroanatomical outcomes relevant for neurodegenerative diseases in humans. Firstly, experimental studies in naive animals do not support a causal relationship between exposure to low frequency magnetic fields and the induction of neuropathology relevant for Alzheimer's disease, but the number of studies relevant for motor neuron disease, multiple sclerosis and Parkinson's disease is too limited to draw conclusions. Secondly, experimental studies in existing animal models for neurodegenerative disease support a therapeutic (beneficial) effect of low frequency magnetic field treatment on behavioural and neuroanatomical abnormalities relevant for dementia (including Alzheimer's disease), multiple sclerosis and Parkinson's disease and no effect on disease progression in models relevant for motor neuron disease.

Given the ubiquitous presence of radiofrequency (RF) radiation sources in modern environments, concerns have been raised regarding their cytotoxic effects on osteoblasts and potential implications for skeletal health. This study investigated the molecular mechanisms underlying these effects, focusing on ferroptosis, a form of regulated cell death implicated in bone pathologies, and the role of Activating Transcription Factor 4 (ATF4). Through comprehensive bioinformatic analyses of public gene expression databases, we identified significant correlations between differentially expressed genes and biological processes associated with lipid metabolism and ferroptosis. MC3T3-E1 osteoblasts were subjected to systematic evaluation under four distinct experimental conditions: a sham-exposed control group and three treatment groups exposed to calibrated RF radiation intensities - low (LRF, 50μW/cm²), moderate (MRF, 150μW/cm²), and high (HRF,450μW/cm²). To elucidate the molecular mechanisms underlying RF-induced ferroptosis, both ATF4 knockdown and overexpression experiments were performed. The findings indicated that RF radiation at 150μW/cm² elicited the most pronounced effects, characterized by reduced osteoblast viability, elevated lipid peroxidation, disrupted redox balance, impaired mitochondrial function, and disturbances in iron homeostasis. Notably, Atf4 knockdown exacerbated these deleterious effects, while its overexpression conferred protection against RF radiation-induced cellular damage. This study demonstrates the crucial role of ATF4 modulation in RF radiation-induced ferroptosis in osteoblasts, a process potentially contributing to bone disorders such as osteoporosis and impaired fracture healing. These findings suggest that targeting ATF4 may represent a promising therapeutic approach to mitigate the effects of RF radiation on bone health, thereby opening new avenues for intervention in environmentally influenced skeletal disorders.

Electromagnetic transduction therapy (EMTT) is a non-invasive magnetic therapy with high oscillating electromagnetic field power. This pilot randomised controlled trial (ChiCTR1900021031) evaluated EMTT's potential efficacy in relieving pain and other non-symptomatic aspects of chronic myofascial pain (CMP). Forty patients with moderate-to-severe CMP were randomised into treatment (real-EMTT) or control (sham-EMTT) group, and received eight sessions of 20-minute real or sham EMTT over four weeks. Generalised estimating equation was used to estimate changes in outcomes, including Numerical Rating Scale (NRS), Brief Pain Inventory Interference Scale (BPI-IS), Beck Depression Inventory (BDI), and Patient Global Impression of Change scale (PGIC) before and up to 6 months after treatment. Recruitment and compliance rates (95% confidence interval) were 39.6% (30.0%-49.8%) and 87.5% (73.2%-95.8%), respectively. There were no significant changes in NRS, BPI-IS and BDI over time (group*time p = 0.929, p = 0.949 and p = 0.608, respectively), and PGIC also did not differ between groups over time (all p > 0.050). Based on the variability of the NRS and non-compliance rate of the patients included in this pilot trial, a total sample size of 148 is required to achieve 80% power if a clinically meaningful reduction in NRS after EMTT treatment is 1.0 (with a superiority margin of 0.3).

Recent studies have demonstrated that radiofrequency (RF) radiation emanating from devices such as mobile phones and Wi-Fi may have adverse effects on male reproductive health. This radiation can elevate testicular temperature, potentially compromising sperm quality and DNA integrity, and influence the specific absorption rate (SAR) across different body regions, leading to detrimental reproductive outcomes. Furthermore, exposure to RF radiation has been linked to conditions that could affect male reproductive function, such as oxidative stress, alterations in ion transitions across cell membranes, and inflammation. The article reviews research conducted on both humans and animal models regarding the effects of electromagnetic radiation on sperm quality, DNA damage, oxidative stress, hormone levels, and testicular function, suggesting that exposure to electromagnetic radiation could have harmful implications for male reproductive health. However, further research is necessary to fully understand the mechanisms and implications of non-ionizing electromagnetic radiation on male infertility.

To better understand the developments and trends of studies on the health impacts of 5th Generation (5 G) antennas, a bibliometric analysis of the literature published in the Web of Science database from 2012 to 2025 was conducted. Before the analysis, the dosimetric quantities "specific absorption rate (SAR)" and "power density (Sab)" used in the examination of the health impacts of antennas were thoroughly defined, and their required limits were provided. Subsequently, information visualization technology was utilized to investigate the yearly distribution of literature, author contributions and collaboration, productive and influential institutions and countries/territories, co-citation analysis, and keyword co-occurrence. However, anticipated publication and citation numbers for the coming years (2025-2029) were predicted regarding the potential health impacts of 5 G antennas using artificial intelligence-assisted forecasting methods. There has been a considerable increase in studies related to health impacts measured by SAR and Sab dosimetric quantities over the last five years, in line with the number of articles published on 5 G antennas. Despite this, no bibliometric analysis has been done so far on the health impact of 5 G antennas below and above 6 GHz. The data presented in this bibliometric study to fill the gap on this subject will provide a better understanding of the health impacts and unique insights to offer good research guidance on 5 G antennas and their attributed adverse health impacts.

This study investigates radiofrequency ablation (RFA) parameters for varicose vein treatment using a three-dimensional mathematical model operating at 470 kHz. The model evaluates how power settings, temperature thresholds, blood flow velocity, and electrode spacing influence therapeutic efficacy and tissue safety. Findings demonstrate that higher power and temperature settings, combined with lower blood flow rates, enhance venous wall heating while minimizing extraluminal tissue damage. Stagnant blood flow optimizes thermal energy delivery, and adjusting electrode spacing reduces the required number of ablations. Temperature-controlled radiofrequency ablation has a controlled electrode temperature for better temperature delivery. This study provides actionable guidance for clinicians to tailor RFA protocols that emphasize management and electrode configuration adjustments for safer and more efficient outcomes in varicose vein treatment.

Terahertz (THz) waves can overcome the side effects of traditional cancer treatment methods with their high absorption by water molecules and provide a new opportunity for the development of cancer treatment. In this study, the effect of a THz ablation system operating at 1.65 THz, recommended for use in cancer treatment, in the treatment of various cancers has been investigated. The proposed system includes three components to ensure high treatment achievement drive and electromagnetic compatibility. The first is a high-performance antenna that will generate radiation at 1.65 THz; the second is a rectangular waveguide that will direct the antenna radiation without loss; and the third is a compact pyramid-structure beam focusing apparatus that will increase focus. In silico studies were carried out for the treatment effects of the proposed system on breast, colon, and skin cancers. For terahertz ablation, treatment effects were examined using voxel data from eight people. Achievement drive parameters such as electric field, magnetic field, specific absorption rate, temperature, and tissue damage rate on healthy and diseased tissues were examined in detail. Our findings show that treatment temperature values have been reached with the THz ablation system depending on the exposure time and cancerous tissue location, and it has been determined that a high rate of tissue damage occurred. No unwanted secondary hotspots have been encountered during the treatment. Consequently, the therapeutic potential of the proposed THz wave ablation system on different cancers encourages further studies to determine the sensitivity and specificity of the system.

Members of the scientific community and the general public are raising concerns about the potential health and environmental effects of radio-frequency electromagnetic fields (RF-EMF) for those living nearby mobile phone base stations (MPBS). This study examined the impact of RF-EMF (900-1900 MHz) on symptoms spanning four health categories: mood-energy, cognitive-sensory, inflammatory, and anatomical issues. A questionnaire identifying health symptoms within these categories, was given to 183 highly exposed and 126 reference residents, matched on demographics. While years of residing near the MPBS influenced the prevalence of some symptoms, proximity to the base station and higher levels of exposure (measured using power density) influenced the prevalence of many of the symptoms. A higher proportion of symptoms was found in residents who were either living within 50 meters of a MPBS or who were exposed to power densities of 5-8 mW/m², for all four health categories. This relationship between exposure level and symptom prevalence was further influenced by age, daily mobile phone use (over 5 h per day), and lifestyle factors, for certain symptoms. Hierarchical regression analysis revealed that level of exposure (power density) was the only factor contributing to the number of symptoms experienced by residents, for all four health categories. An unexpected finding was that among the more highly exposed residents, the younger individuals (under 40 years) reported more inflammation related issues than older individuals. These results underscore the need to inform policymakers regarding the benefits of adopting a precautionary approach to potential risks associated with RF-EMF exposures from MPBS.