Clinical and Experimental Obstetrics & Gynecology最新文献

{"title":"Value of Three-Dimensional Power Doppler Ultrasound in Quantitative Assessment of Early Diminished Ovarian Reserve During Perimenopause","authors":"Yunfei Ma, Yiyun Wu","doi":"10.31083/j.ceog5102042","DOIUrl":"https://doi.org/10.31083/j.ceog5102042","url":null,"abstract":"Background : To evaluate the value of transvaginal three-dimensional power Doppler ultrasound (3D-PD-US) in quantitative assessment of early diminished ovarian reserve (DOR) among perimenopausal women. Methods : A total of 166 perimenopausal women with DOR were selected from February 2019 to December 2022, including 63 in the early stage and 103 in the mid-to-late stage. Ovarian reserve was assessed by biochemical testing and 3D-PD-US imaging. Biochemical indicators included antimüllerian hormone (AMH), basal serum follicle stimulating hormone (FSH) and estradiol (E 2 ). 3D-PD-US indicators involved ovarian volume (OV), antral follicle number (AFC), vascularization index (VI), blood flow index (FI), and vascularization flow index (VFI). The accuracies of two methods were compared. Results : There were significant differences in OV, AFC, VI, FI, and VFI between the early DOR group and the mid-to-late DOR group (all p < 0.05). FSH had significant negative correlations with OV, AFC, VI, FI and VFI, with correlation coefficients of –0.342, –0.381, –0.179, –0.123, and –0.175, respectively (all p < 0.05). Conclusions : 3D-PD-US may serve as a quantitative method for early detection of DOR in perimenopausal women.","PeriodicalId":505527,"journal":{"name":"Clinical and Experimental Obstetrics &amp; Gynecology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140444286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Effect of Psychological Nursing Combined with Fluoxetine in the Treatment of Postoperative Anxiety in Patients with Endometrial Cancer","authors":"Na Sun, Weijiao Yan, Linlin Wang, Jing Wang, Lin Wang","doi":"10.31083/j.ceog5102044","DOIUrl":"https://doi.org/10.31083/j.ceog5102044","url":null,"abstract":"Background : This study aimed to assess the effectiveness of a combined approach involving psychological nursing and fluoxetine in improving the mental well-being and quality of life in patients undergoing hysterectomy. Methods : Patients were categorized into three groups: control, intervention group A, and intervention group B, based on the nursing plan. The control group received routine nursing care, whereas intervention group A received routine nursing care and psychological support. Intervention B received routine nursing care, psychological support, and fluoxetine treatment. Psychological symptoms, anxiety, depression, quality of life, and nursing satisfaction were compared between the three groups before and after nursing interventions. Results : The outcomes of intervention groups A and B were superior to those of the control group. Furthermore, intervention group B outperformed intervention group A. After the interventions, the nursing satisfaction was higher in both intervention groups, A and B, compared to the control group. In contrast, intervention B exhibited the highest satisfaction scores, surpassing those of intervention group A. Conclusions : The combination of psychological nursing and fluoxetine therapy for patients with endometrial cancer undergoing hysterectomy holds significant promise in alleviating anxiety and depression, improving their overall quality of life, and increasing nursing satisfaction.","PeriodicalId":505527,"journal":{"name":"Clinical and Experimental Obstetrics &amp; Gynecology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140444791","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of the Clinical Outcomes in Women with A or D PCOS Phenotypes versus Single Polycystic Ovary undergoing IVF-ET","authors":"Fangfang Dai, Yasong Geng, Meiyang Du, Shusong Wang, Guozhen Li, Linlin Tao, Bo Zheng","doi":"10.31083/j.ceog5102038","DOIUrl":"https://doi.org/10.31083/j.ceog5102038","url":null,"abstract":"Background : The impact of polycystic ovary syndrome (PCOS) on endometrial receptivity and embryo quality is a subject of debate. Different PCOS patient types may exhibit different effects on these factors. This study aimed to identify causes for low live birth rate by comparing endometrial receptivity and embryo quality among different PCOS types. Methods : Overall, a total of 767 PCOS patients with first in vitro fertilization (IVF)/intracytoplasmic sperm injection (ICSI) treatment classified into phenotype A (n = 167 patients) and phenotype D (n = 600 patients) were eligible for analysis. Patients with single polycystic ovary (n = 406 patients) served as a control group to exclude the advantages of clinical outcome from higher number of oocytes retrieved in women with PCOS. Results : In phenotype A and D, Anti-Müllerian hormone (AMH), antral follicle count (AFC) and basic estradiol were significantly higher compared to single polycystic ovary. However, estradiol, progestin and endometrial thickness on the human chorionic gonadotropin (hCG) day were significantly decreased. In fresh cycles, phenotype A had a significant statistical decrease in the live birth rate compared with single polycystic ovary (35/78 [44.87%] vs. 135/233 [57.94%], p < 0.05), although there was no significant difference in the number of embryo transplants and clinical pregnancy rate among the three groups. It might be associated with the significant reduction of total gonadotropin (Gn) dose, Gn duration, and follicular output rate (FORT) in all the typed PCOS groups. In the first frozen embryo transfer (ET) cycles, no significant difference was observed for estrogen, progestin, or endometrial thickness on the day of ovulation and live birth rate. Women with live birth had a higher estradiol on the hCG day in the phenotype A (3763 [3121, 4752] vs. 2954 [2112, 4036] ng/mL) while a lower estradiol in the single polycystic ovary (3312 [2341, 4465] vs. 3417 [2350, 4638] ng/mL). In multivariate logistic regression analysis, estradiol on the hCG day was a significant independent factor predicting live birth for women with phenotype A (odds ratio (OR) > 1.000, 95% confidence interval (95% CI): 1.000–1.001), p = 0.034) and single polycystic ovary (OR < 1.000, 95% CI: 0.999–1.000, p = 0.013) in fresh ET. Conclusions : The various subtypes of PCOS have no significant adverse effect on embryonic outcome. It was not directly caused by PCOS; however, low levels of estradiol may be the reason for the low live birth rate owing to significant reduction of total Gn dose, Gn duration and FORT as a result to low incidence of ovarian hyperstimulation syndrome (OHSS) in phenotype A.","PeriodicalId":505527,"journal":{"name":"Clinical and Experimental Obstetrics &amp; Gynecology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140442372","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Knowledge, Awareness and Behaviors of Somalian Female University Students regarding Cervical Cancer, HPV and the HPV Vaccine: A Cross-Sectional Study","authors":"Şeyma Zehra Altunkurek, S. H. Mohamed","doi":"10.31083/j.ceog5102041","DOIUrl":"https://doi.org/10.31083/j.ceog5102041","url":null,"abstract":"Background : Awareness and knowledge of cervical cancer and human papillomavirus (HPV) are consistently poor in low-resource settings. In addition, there is insufficient evidence about young people’s knowledge and understanding of cervical cancer, risk factors, screening and HPV vaccination in these countries. This study was conducted to determine the knowledge, attitudes and behaviors of students studying at a university in Somalia regarding cervical cancer and how to prevent it. Methods : This cross-sectional study was conducted among students of the Faculty of Health Sciences at a private university in Mogadishu, Somalia, between January and March 2021. The sample of study consisted of a total of 220 female students. The data of the study were collected using a questionnaire consisting of 32 questions evaluating the knowledge and attitudes of the students regarding cervical cancer, HPV and the HPV vaccine. Results : In the study, 59.1% of the participants stated that they had previously heard of cervical cancer, 69.1% did not know that it was fatal, 49.1% stated that it was preventable, 48.2% did not know the causes of cervical cancer, and 2.7% had a family history of cervical cancer. In addition, it was determined that 75.9% of the participants did not know that HPV caused cervical cancer. When the knowledge of the participants about HPV and the HPV vaccine was examined, it was determined that 55% of them had not previously heard of HPV. When asked about how HPV is transmitted they stated that this occurred through kissing (73.2%), sexual intercourse (58.2%) and using items owned by individuals infected with HPV (41.8%). None of the participants had received the HPV vaccine. Of these, 72.3% stated that they had not been vaccinated because they did not know about the vaccine. According to 40.9% of the participants, both boys and girls should be vaccinated; however, 63.6% stated that they did not know at what age individuals should receive a vaccine. In addition, 71.4% of participants said they did not know that the HPV vaccine protects against HPV-related sexually transmitted diseases. There was a statistically significant relationship only between the participants’ financial status and the awareness variable ( p < 0.05). It was concluded that the awareness of those participants whose economic situation was good was statistically high. Conclusions : This was our first study on the subject in Somalia and it revealed that the level of knowledge of female university students studying in the field of health sciences regarding cervical cancer, the HPV vaccine and prevention methods were insufficient, as were the vaccination rates. In future research, the reasons for these inadequacies should be revealed through more comprehensive studies.","PeriodicalId":505527,"journal":{"name":"Clinical and Experimental Obstetrics &amp; Gynecology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140443944","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retrospective Analysis of Molecular Markers in Endometrial Cancer: Single Center Experience","authors":"Cem Yagmur Ozdemir, D. Arıoz, Nayif Çiçekli, Mariam Chkhikvadze, F. Bilir, Cigdem Ozdemir, Hacer Demir, Evrim Suna Arıkan Soylemez","doi":"10.31083/j.ceog5102043","DOIUrl":"https://doi.org/10.31083/j.ceog5102043","url":null,"abstract":"Background : To emphasize the effect of molecular markers on prognosis in endometrial cancer, in addition to the International Federation of Gynecology and Obstetrics (FIGO) 2009 classification. Methods : The records of 160 patients with endometrial cancer between 2008 and 2022 were retrospectively reviewed. Staging was done according to FIGO 2009 criteria. Patients were divided into 4 groups according to molecular classification. If one had polymerase epsilon ( POLE ) mutation, the patient was included in POLE ultramutated (POLEmut) group. In case of intakt POLE , but abnormal staining of mismatch repair (MMR), the group was diagnosed as mismatch repair defciency (MMRd). If there was only p53 abnormal results detected, that group was p53-abnormal (p53mut). If no mutation at all, that group was categorized as non-specific molecular profile (NSMP). The Kaplan-Meier method was used to evaluate overall survival and progression-free survival. Survival rates were compared for molecular markers. Results : According to the molecular analysis, 4 patients (2.5%) were classifed as POLEmut group, 53 patients (33.1%) in the MMRd group, 18 patients (11.3%) had p53mut, and 85 patients (53.1%) into the NSMP group. 5-year overall survival was 79.4%, 5-year progression-free survival was 90%. 5-year overall survival was 75% in POLEmut group, 84.9% in MMRd group, 38.9% in p53mut group and 84.7% in NSMP group ( p = 0.001). 5-year progression-free survival was 100% in POLEmut group, 96.2% in MMRd group, 77.8% in p53mut group and 88.2% in NSMP group ( p = 0.082). Conclusion : Our study shows the prognostic value of the molecular endometrial cancer classification. Patients with p53mut have a poor progression-free survival, POLEmut endometrial cancer have a good prognosis. In this study, we wanted to demonstrate the importance of molecular markers in endometrium cancer and their contribution to prognosis.","PeriodicalId":505527,"journal":{"name":"Clinical and Experimental Obstetrics &amp; Gynecology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140442577","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Value of CA125 and CA19-9 in the Diagnosis of Stage Ⅲ and Ⅳ Endometriosis","authors":"Wenwen Zhang, H. Tang, Qiucheng Jia, Jiming Chen, Genhai Zhu","doi":"10.31083/j.ceog5102045","DOIUrl":"https://doi.org/10.31083/j.ceog5102045","url":null,"abstract":"Background : To evaluate the effect of carbohydrate antigen 125 (CA125) and CA19-9 in distinguishing stage Ⅲ and Ⅳ endometriosis from benign and malignant tumors, and to explore whether it is related to the clinical features of the disease. Methods : In a retrospective cohort study based on clinical data from hospitals, a total of 183 patients with pathologically confirmed diagnosis of ovarian endometriotic cysts (OEC) in Hainan Provincial People’s Hospital for surgical treatment from January 2019 to August 2022 were selected as the case group, and a total of 276 cases of benign diseases, including 184 cases of benign ovarian tumors, 94 cases of gynecological common diseases, and 102 cases of malignant ovarian tumors were selected as the control group, with a total of 276 cases of benign diseases, including 184 cases of benign ovarian tumors, 94 cases of gynecological common diseases, and 102 cases of malignant ovarian tumors. There were also 23 cases of ruptured ectopic cysts. We compared the clinical characteristics (age of onset, fertility, dysmenorrhea, preoperative CA125 and CA19-9 values) of the patients in the OEC group with those of the other control groups; analyzed the serum CA125 and CA19-9 values in relation to the pathological characteristics of OEC (recurrence, unilateral and bilaterality, multilocularity and unilocularity, rupture, dysmenorrhea, fertility, and staging); and analyzed the CA125 and CA19-9 values by unordered logistic regression, CA19-9 to predict OEC; sensitivity, specificity and cut-off values of CA125, CA19-9 and their combined indexes to diagnose OEC. Results : The symptoms of dysmenorrhea and infertility in OEC group were significantly higher than those in the other three groups. The preoperative CA125 value in OEC group was higher than that in benign tumor and other gynecological diseases group, and significantly lower than that in malignant tumor group. There was no significant difference in the value of CA19-9 and CA125 in the degree of dysmenorrhea, recurrence and infertility. The values of CA19-9 and CA125 of multilocular cysts were higher than those of unicameral cysts, bilateral cysts were higher than unilateral cysts, and ruptured cysts were significantly higher than unruptured cysts. The value of CA125 in the dysmenorrhea group was higher than that in the non-dysmenorrhea group, and that in the fourth stage was higher than that in the third stage, and the difference was statistically significant ( p < 0.05). Unordered multicategorical logistic regression analysis determined that CA125, could be a predictor in the comparison of OEC with benign disease; in the benign control group the cut-off value for CA125 was > 23.","PeriodicalId":505527,"journal":{"name":"Clinical and Experimental Obstetrics &amp; Gynecology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140444546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factors Associated with Abnormal Uterine Bleeding in Perimenopausal Women","authors":"Radenko Ivanović, Bojan Joksimović, Vladimir Čančar, Helena Marić, Draženka Matović, Nenad Lalović, Radiša Pavlović, Miloš Milosavljević, Jovana Milosavljević, Slobodan Janković","doi":"10.31083/j.ceog5102037","DOIUrl":"https://doi.org/10.31083/j.ceog5102037","url":null,"abstract":"Background : Abnormal uterine bleeding (AUB) is one of the most common health problems encountered in women of the peri-menopausal age group. The aim of this study was to investigate the characteristics of functional AUB in perimenopausal women, and to identify predictors of the occurrence of functional AUB in perimenopausal women. Methods : This was a cross-sectional study that included 45 women with complaints of AUB admitted to the gynecology ward in the University Hospital in Foča, and 45 women without AUB who underwent a gynecological examination in the Primary Health Center in Foča, Bosnia and Herzegovina. We included women with AUB who had a normal ultrasound finding without obvious genital or cervical lesions, and who were not on hormonal therapy. The existence of AUB was determined on the basis of a clinical examination by a gynecologist and existing medical documentation. A logistic regression model was used to assess the possible relationship between the occurrence of the functional AUB and the risk factors for its occurrence. Results : The mean patient age was 48.38 ± 2.40 years. There was no significant difference in age, frequency of physical activity, or previous use of oral contraceptives between the two groups of patients divided by the presence of the functional AUB in perimenopause. The logistic regression model showed that age ( p = 0.008), high values of body mass index (BMI) ( p = 0.001), consumption of alcohol and cigarettes on a daily basis ( p = 0.001), and hypertension ( p = 0.046) represented significant risk factors associated with functional AUB in perimenopausal women. Conclusions : During routine exams of women approaching menopause, gynecolo-gists should emphasize the harms of smoking and alcohol use, as well as the significance of non-pharmacological and pharmacological methods for the treatment of obesity and hypertension.","PeriodicalId":505527,"journal":{"name":"Clinical and Experimental Obstetrics &amp; Gynecology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140452538","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adverse Pregnancy Outcomes and Prognostic Factors in Hepatitis B Virus Patients with Intrahepatic Cholestasis During Pregnancy","authors":"Chong Zhang, Hong Wei, Zhiqiang Zhao, Yunxia Zhu","doi":"10.31083/j.ceog5102036","DOIUrl":"https://doi.org/10.31083/j.ceog5102036","url":null,"abstract":"Background : We conducted this study to investigate adverse pregnancy outcomes of hepatitis B virus infection coexistng with intra-hepatic cholestasis in pregnant women, along with identifying associated risk factors. Methods : We retrospectively collected study data from Beijing Youan Hospital in China spanning January 2014 to December 2021. The study included 220 patients, divided into two groups: Group I consisted of 110 patients with hepatitis B virus infection and intrahepatic cholestasis during pregnancy, while Group II comprised 110 patients with hepatitis B virus infection alone. Maternal demographics, laboratory values, obstetric complications, and adverse pregnancy outcomes were collected and analyzed between Groups I and II. To investigate the features of hepatitis B virus infection with intrahepatic cholestasis in pregnancy patients further, we also evaluated risk factors of adverse pregnancy outcomes in Group I. Results : Adverse pregnancy outcomes, including preterm birth ( < 37 weeks (w)), postpartum hemorrhage, meconium-stained amniotic fluid, neonatal asphyxia, neonate intensive care unit admission and small for gestational age rates were significantly increased for Group I compared with Group II ( p < 0.05). In hepatitis B virus infection patients with intrahepatic cholestasis during pregnancy, elevated total serum bile acids independently correlated with six adverse pregnancy outcomes. Conclusions : Pregnant patients with both hepatitis B virus infection and intrahepatic cholestasis experienced a higher occurrence of adverse pregnancy outcomes compared to those with Hepatitis B virus infection alone. Total serum bile acids were an independent risk factor for adverse pregnancy outcomes in Hepatitis B virus infection with intrahepatic cholestasis during pregnancy. Clinical Trial Registration : The study was registered with https://classic.clinicaltrials.gov/ (no.: zx10201201).","PeriodicalId":505527,"journal":{"name":"Clinical and Experimental Obstetrics &amp; Gynecology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140452710","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between Pre-Pregnancy Body Mass Index, Gestational Weight Gain, and Birth Defects, a Retrospective Study","authors":"Zhou Chu, Mingming Qi, Zaili Yu, Li Mi, Jin Long, Guohong Hu","doi":"10.31083/j.ceog5102034","DOIUrl":"https://doi.org/10.31083/j.ceog5102034","url":null,"abstract":"","PeriodicalId":505527,"journal":{"name":"Clinical and Experimental Obstetrics &amp; Gynecology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139806318","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness, Tolerability and Safety of a Compound Based on D-chiro-inositol + Myo-inositol, Melatonin, Folic Acid, and Vitamin D in Patients with Menstrual Cycle Disorders","authors":"Silvia P. González, María del Mar Rubio, Helena Losa","doi":"10.31083/j.ceog5102035","DOIUrl":"https://doi.org/10.31083/j.ceog5102035","url":null,"abstract":"","PeriodicalId":505527,"journal":{"name":"Clinical and Experimental Obstetrics &amp; Gynecology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139807186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}