Lorena Gutiérrez-Hermoso, Patricia Catalá-Mesón, Carmen Écija-Gallardo, Cecilia Peñacoba-Puente
Background : Pregnancy can be a stressful time that affects a woman’s health, potentially leading to postpartum depression (PPD). Research has highlighted the importance of certain cognitive variables in coping with depressive symptoms. Specifically, among mothers, the perception of maternal competence has been shown to be a protective factor against postpartum depression. Conversely, other variables such as external locus of control (ELoC), have been identified as risk factors, although the research in this area is less abundant. It would be valuable to explore the role of an external locus of control through integrative models that consider its possible interactions throughout pregnancy and postpartum. The aim of the present study was to evaluate the relationship between the external locus of control (at the beginning of pregnancy) and postpartum depression (four months after childbirth), with emotional coping as a mediating variable and maternal competence as a moderating variable. Methods : A prospective cohort study was conducted with 120 pregnant women recruited from a public hospital in Madrid, Spain. External locus of control was assessed by Rotter’s locus of control scale during the first-trimester of pregnancy, non-adaptive emotional coping was assessed by Coping Strategies Questionnaire (CAE) during the third-trimester of pregnancy, and postpartum depression was assessed by Edinburgh Postnatal Depression scale and perceptions of maternal competence were evaluated by Mother and Baby Scale, both during the puerperium. Multivariate regression analyses were conducted using a moderated mediation model, controlling for anxiety and depression. Results : Results showed a significant mediating effect of emotional coping between external locus of control and postpartum depression. The effect of external locus of control on postpartum depression, considering the effect of emotional coping, was statistically significant (direct effect: β = 4.73, t = 1.23, p = 0.006, [95% confidence interval (CI) = 1.24/2.39]). The effect of maternal competence as a moderator within the mediation model was also significant (total effect: c = 0.351, t = 2.37, p = 0.020, [95% CI = 0.057/0.064]). Regarding covariates, a significant effect of depressive symptoms on moderation-mediation model was observed ( β = 5.57, t = 3.49, p = 0.009, [95% CI = 2.38/8.75]). The moderated mediation model, including maternal competence as a moderator, suggested that the relationship between external locus of control on postpartum depression, mediated by emotional coping, varied across different levels of maternal competence ( β = –0.150, [95% CI = –0.0188/–0.241]), indicating buffering effects at medium ( β = –0.195, p = 0.002) and high ( β = –0.258, p < 0.001) levels of maternal competence. Prenatal anxious-depressive symptoms (covariates) did not exhibit significant effects on the proposed moderated mediation model. Conclusions : External locus of control predicts potential risk for
{"title":"Locus of Control and Non-Adaptive Coping in Postpartum Depression: A Prospective Study with Maternal Competence as a Buffer","authors":"Lorena Gutiérrez-Hermoso, Patricia Catalá-Mesón, Carmen Écija-Gallardo, Cecilia Peñacoba-Puente","doi":"10.31083/j.ceog5107157","DOIUrl":"https://doi.org/10.31083/j.ceog5107157","url":null,"abstract":"Background : Pregnancy can be a stressful time that affects a woman’s health, potentially leading to postpartum depression (PPD). Research has highlighted the importance of certain cognitive variables in coping with depressive symptoms. Specifically, among mothers, the perception of maternal competence has been shown to be a protective factor against postpartum depression. Conversely, other variables such as external locus of control (ELoC), have been identified as risk factors, although the research in this area is less abundant. It would be valuable to explore the role of an external locus of control through integrative models that consider its possible interactions throughout pregnancy and postpartum. The aim of the present study was to evaluate the relationship between the external locus of control (at the beginning of pregnancy) and postpartum depression (four months after childbirth), with emotional coping as a mediating variable and maternal competence as a moderating variable. Methods : A prospective cohort study was conducted with 120 pregnant women recruited from a public hospital in Madrid, Spain. External locus of control was assessed by Rotter’s locus of control scale during the first-trimester of pregnancy, non-adaptive emotional coping was assessed by Coping Strategies Questionnaire (CAE) during the third-trimester of pregnancy, and postpartum depression was assessed by Edinburgh Postnatal Depression scale and perceptions of maternal competence were evaluated by Mother and Baby Scale, both during the puerperium. Multivariate regression analyses were conducted using a moderated mediation model, controlling for anxiety and depression. Results : Results showed a significant mediating effect of emotional coping between external locus of control and postpartum depression. The effect of external locus of control on postpartum depression, considering the effect of emotional coping, was statistically significant (direct effect: β = 4.73, t = 1.23, p = 0.006, [95% confidence interval (CI) = 1.24/2.39]). The effect of maternal competence as a moderator within the mediation model was also significant (total effect: c = 0.351, t = 2.37, p = 0.020, [95% CI = 0.057/0.064]). Regarding covariates, a significant effect of depressive symptoms on moderation-mediation model was observed ( β = 5.57, t = 3.49, p = 0.009, [95% CI = 2.38/8.75]). The moderated mediation model, including maternal competence as a moderator, suggested that the relationship between external locus of control on postpartum depression, mediated by emotional coping, varied across different levels of maternal competence ( β = –0.150, [95% CI = –0.0188/–0.241]), indicating buffering effects at medium ( β = –0.195, p = 0.002) and high ( β = –0.258, p < 0.001) levels of maternal competence. Prenatal anxious-depressive symptoms (covariates) did not exhibit significant effects on the proposed moderated mediation model. Conclusions : External locus of control predicts potential risk for ","PeriodicalId":505527,"journal":{"name":"Clinical and Experimental Obstetrics & Gynecology","volume":" 21","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141825962","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Xiaxia Cao, Xu Ding, Huihui Sun, Lihong Zhang, Xiang Li
Background : This study aimed to evaluate whether dexmedetomidine (DEX) can relieve postoperative pain and reduce stress reaction after laparoscopic uterine fibroids (UF) surgery. Methods : This randomized controlled study included 100 patients age range of 40–60 years, American Society of Anesthesiologists (ASA) 1–2 grade, admitted for laparoscopic UF surgery from January 2020 to October 2023. The patients were randomly allocated to the DEX group (n = 50) and non-DEX group (n = 50). The visual analogue scale (VAS), Richmond Agitation-Sedation Scale (RASS) score, anesthesia time, spontaneous breathing recovery time, consciousness recovery time, extubation time, and recovery room time were recorded. Results : The VAS of the DEX group was smaller than that of the non-DEX group at half an hour, but there was no significant difference in VAS at 1 h, 12 h and 24 h. Dex group has a RASS value closer to zero than non-DEX group at half an hour. There was no significant difference in RASS at 1 h, 12 h, or 24 h. There were differences in spontaneous breathing recovery time, consciousness recovery time, extubation time, recovery room time, chills and nausea between the two groups. Conclusion : Application of DEX in perioperative period can relieve postoperative pain, reduce stress reaction after laparoscopic UF surgery. Clinical Trial Registration : The study has been registered on https://classic.clinicaltrials.gov/ (registration number: NCT03524950).
{"title":"Effect of Application of Dexmedetomidine in Perioperative Period on Postoperative Pain, Stress in Patients Undergoing Laparoscopic Uterine Fibroids Surgery: A Randomized Controlled Study","authors":"Xiaxia Cao, Xu Ding, Huihui Sun, Lihong Zhang, Xiang Li","doi":"10.31083/j.ceog5107160","DOIUrl":"https://doi.org/10.31083/j.ceog5107160","url":null,"abstract":"Background : This study aimed to evaluate whether dexmedetomidine (DEX) can relieve postoperative pain and reduce stress reaction after laparoscopic uterine fibroids (UF) surgery. Methods : This randomized controlled study included 100 patients age range of 40–60 years, American Society of Anesthesiologists (ASA) 1–2 grade, admitted for laparoscopic UF surgery from January 2020 to October 2023. The patients were randomly allocated to the DEX group (n = 50) and non-DEX group (n = 50). The visual analogue scale (VAS), Richmond Agitation-Sedation Scale (RASS) score, anesthesia time, spontaneous breathing recovery time, consciousness recovery time, extubation time, and recovery room time were recorded. Results : The VAS of the DEX group was smaller than that of the non-DEX group at half an hour, but there was no significant difference in VAS at 1 h, 12 h and 24 h. Dex group has a RASS value closer to zero than non-DEX group at half an hour. There was no significant difference in RASS at 1 h, 12 h, or 24 h. There were differences in spontaneous breathing recovery time, consciousness recovery time, extubation time, recovery room time, chills and nausea between the two groups. Conclusion : Application of DEX in perioperative period can relieve postoperative pain, reduce stress reaction after laparoscopic UF surgery. Clinical Trial Registration : The study has been registered on https://classic.clinicaltrials.gov/ (registration number: NCT03524950).","PeriodicalId":505527,"journal":{"name":"Clinical and Experimental Obstetrics & Gynecology","volume":" January","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141824093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background : Torsion is a condition that affects the adnexa completely or partially and causes circulatory disorders in the ovary. To the best of our knowledge, it is unclear how long it takes for the damage to the ovary during the torsion process to become irreversible. The aim of our study was to evaluate the pathology results and ovarian ischemia status of patients who underwent surgery with the indication of adnexal torsion in our clinic, and to determine the relationship between operation timing, and ovarian viability. Methods : The study was conducted retrospectively in the department of gynecology and obstetrics at Dokuz Eylul University Hospital between April 2023 and October 2023. Cases who presented to our clinic with acute abdominal pain and decided to undergo surgery due to suspicion of torsion were included in the study. Patients who were decided to undergo surgery within 6 hours after the onset of symptoms constituted group 1 (n = 26), and patients who were decided to undergo surgery after 6 hours after the onset of symptoms constituted group 2 (n = 36). Statistical analyses were conducted using IBM SPSS Statistics version 26.0 (IBM Inc., Chicago, IL, USA). Results : The average age of the patients in group 1 was significantly lower than that in group 2 ( p < 0.001). When both groups were compared, the rate of previous torsion history in group 1 was found significantly higher than that in group 2 ( p = 0.04). When both groups were compared in terms of laboratory and imaging findings, no difference was detected between the groups. When both groups were compared in terms of torsion type, ligamentopexy application, torsion area, and torsion direction, no difference was found between the groups. The surgery time in group 2 was found significantly longer than that in group 1 ( p < 0.0001). When both groups were compared in terms of intraoperative necrosis, no significant difference was found between the groups ( p = 0.3). Conclusions : With the current data, there is no definitive time limit for the effect of the timing of surgical intervention on ovarian viability in adnexal torsion.
{"title":"Effect of Surgical Intervention Timing on Ovarian Viability in Adnexal Torsion: A Cross-Sectional Study","authors":"A. Akdöner, O. Yavuz","doi":"10.31083/j.ceog5107159","DOIUrl":"https://doi.org/10.31083/j.ceog5107159","url":null,"abstract":"Background : Torsion is a condition that affects the adnexa completely or partially and causes circulatory disorders in the ovary. To the best of our knowledge, it is unclear how long it takes for the damage to the ovary during the torsion process to become irreversible. The aim of our study was to evaluate the pathology results and ovarian ischemia status of patients who underwent surgery with the indication of adnexal torsion in our clinic, and to determine the relationship between operation timing, and ovarian viability. Methods : The study was conducted retrospectively in the department of gynecology and obstetrics at Dokuz Eylul University Hospital between April 2023 and October 2023. Cases who presented to our clinic with acute abdominal pain and decided to undergo surgery due to suspicion of torsion were included in the study. Patients who were decided to undergo surgery within 6 hours after the onset of symptoms constituted group 1 (n = 26), and patients who were decided to undergo surgery after 6 hours after the onset of symptoms constituted group 2 (n = 36). Statistical analyses were conducted using IBM SPSS Statistics version 26.0 (IBM Inc., Chicago, IL, USA). Results : The average age of the patients in group 1 was significantly lower than that in group 2 ( p < 0.001). When both groups were compared, the rate of previous torsion history in group 1 was found significantly higher than that in group 2 ( p = 0.04). When both groups were compared in terms of laboratory and imaging findings, no difference was detected between the groups. When both groups were compared in terms of torsion type, ligamentopexy application, torsion area, and torsion direction, no difference was found between the groups. The surgery time in group 2 was found significantly longer than that in group 1 ( p < 0.0001). When both groups were compared in terms of intraoperative necrosis, no significant difference was found between the groups ( p = 0.3). Conclusions : With the current data, there is no definitive time limit for the effect of the timing of surgical intervention on ovarian viability in adnexal torsion.","PeriodicalId":505527,"journal":{"name":"Clinical and Experimental Obstetrics & Gynecology","volume":" 46","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141827818","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background : During the embryonic stage, the inferior vena cava (IVC) is an important conduit for the hepatic vein and ductus venosus to drain into the right atrium. For fetuses with IVC abnormalities, the prognosis may be favorable if the condition is not complicated with other malformations, but would be poor if atrial isomerism coexists. In severe cases, edema, intrauterine fetal death, and atrioventricular block may occur. Therefore, comprehensive prenatal ultrasound that provides detailed information about IVC abnormalities may be clinically significant. Methods : A total of 180 fetuses diagnosed with IVC anomalies via prenatal ultrasound at Hospital of Chengdu University of Traditional Chinese Medicine and Sichuan Provincial Maternity and Child Health Care Hospital from January, 2017 to December, 2022 were included in this study. Their ultrasound image characteristics, associated intra-or extracardiac malformations and pregnancy outcomes were retrospectively analyzed. Results : Among the 180 fetuses, 59 cases were diagnosed with interrupted IVC (53 cases with the interruption of the hepatic segment of the right IVC and 6 cases with the interruption of the entire right IVC), 1 case was diagnosed with the stenosis of the hepatic segment of the right IVC, 90 cases were diagnosed with left sided IVC, 29 cases with double IVC, and 1 case with abnormal connection of the IVC to the left atrium. Moreover, 33 cases had intracardiac malformations and 36 cases had extracardiac malformations. Pregnancy outcomes: 160 fetuses were live born, and their prenatal ultrasound diagnoses were confirmed by computed tomography (CT)/magnetic resonance imaging (MRI) or surgery; the remaining 20 fetuses were terminated due to serious malformations, and their prenatal ultrasound diagnoses were confirmed by pathologic examination. Conclusions : Prenatal ultrasound can clearly reveal the fetal IVC abnormalities and the associated intra-or extracardiac malformations. For suspected cases, attention should be focused on prenatal ultrasound examinations in order to obtain valuable information for prenatal consultation and subsequent procedures and care.
{"title":"Prenatal Ultrasound in Fetal Inferior Vena Cava Abnormalities: Image Characteristics and Clinical Relevance","authors":"Huaying Yan, Chunguo Zhang, Yu Kang, Lihong He","doi":"10.31083/j.ceog5107156","DOIUrl":"https://doi.org/10.31083/j.ceog5107156","url":null,"abstract":"Background : During the embryonic stage, the inferior vena cava (IVC) is an important conduit for the hepatic vein and ductus venosus to drain into the right atrium. For fetuses with IVC abnormalities, the prognosis may be favorable if the condition is not complicated with other malformations, but would be poor if atrial isomerism coexists. In severe cases, edema, intrauterine fetal death, and atrioventricular block may occur. Therefore, comprehensive prenatal ultrasound that provides detailed information about IVC abnormalities may be clinically significant. Methods : A total of 180 fetuses diagnosed with IVC anomalies via prenatal ultrasound at Hospital of Chengdu University of Traditional Chinese Medicine and Sichuan Provincial Maternity and Child Health Care Hospital from January, 2017 to December, 2022 were included in this study. Their ultrasound image characteristics, associated intra-or extracardiac malformations and pregnancy outcomes were retrospectively analyzed. Results : Among the 180 fetuses, 59 cases were diagnosed with interrupted IVC (53 cases with the interruption of the hepatic segment of the right IVC and 6 cases with the interruption of the entire right IVC), 1 case was diagnosed with the stenosis of the hepatic segment of the right IVC, 90 cases were diagnosed with left sided IVC, 29 cases with double IVC, and 1 case with abnormal connection of the IVC to the left atrium. Moreover, 33 cases had intracardiac malformations and 36 cases had extracardiac malformations. Pregnancy outcomes: 160 fetuses were live born, and their prenatal ultrasound diagnoses were confirmed by computed tomography (CT)/magnetic resonance imaging (MRI) or surgery; the remaining 20 fetuses were terminated due to serious malformations, and their prenatal ultrasound diagnoses were confirmed by pathologic examination. Conclusions : Prenatal ultrasound can clearly reveal the fetal IVC abnormalities and the associated intra-or extracardiac malformations. For suspected cases, attention should be focused on prenatal ultrasound examinations in order to obtain valuable information for prenatal consultation and subsequent procedures and care.","PeriodicalId":505527,"journal":{"name":"Clinical and Experimental Obstetrics & Gynecology","volume":" 11","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141831384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objectives : This review aims to summarize the current literature on recurrent and metastatic (r/m) cervical cancer, especially first-line and second-line immunotherapy. Clinical benefits including efficacy and safety of new therapeutic options are also reviewed. Mechanism : The published relevant articles were searched from multiple databases, including PubMed, Ovid, and Scopus. The key terms included recurrent cervical cancer, advanced cervical cancer, metastatic cervical cancer, and immunotherapy. The data of the latest clinical trials was retrieved from ClinicalTrials.gov (https://clinicaltrials.gov). Findings in Brief : In late 2021, pembrolizumab in combination with chemotherapy with or without bevacizumab was approved as the first-line treatment for recurrent and metastatic cervical cancer. Also tisotumab vedotin was approved as the second-line immunotherapy for r/m cervical cancer. Moreover, a plethora of clinical immunotherapy trials were approved in different countries, and some received as breakthrough therapy designations. Pembrolizumab, cemiplimab, atezolizumab, cadonilimab, zimberelimab, balstilimab and zalifrelimab, nivolumab, and tisotumab vedotin were reviewed with overall survival, progression-free survival, rate of objective response and adverse effects in order to review the efficacy and safety of different therapeutic option. Conclusions : The majority of trials indicated that immunotherapy can significantly improve the overall survival (OS) and progression-free survival (PFS) of r/m cervical cancer patients without negatively affecting health-related quality-of-life (HRQoL), and demonstrated that immunotherapy is an effective and safe treatment for r/m cervical cancer.
{"title":"Immunotherapy for Recurrent and Metastatic Cervical Cancer: A Review","authors":"Yuke Wu, Xiang He","doi":"10.31083/j.ceog5107155","DOIUrl":"https://doi.org/10.31083/j.ceog5107155","url":null,"abstract":"Objectives : This review aims to summarize the current literature on recurrent and metastatic (r/m) cervical cancer, especially first-line and second-line immunotherapy. Clinical benefits including efficacy and safety of new therapeutic options are also reviewed. Mechanism : The published relevant articles were searched from multiple databases, including PubMed, Ovid, and Scopus. The key terms included recurrent cervical cancer, advanced cervical cancer, metastatic cervical cancer, and immunotherapy. The data of the latest clinical trials was retrieved from ClinicalTrials.gov (https://clinicaltrials.gov). Findings in Brief : In late 2021, pembrolizumab in combination with chemotherapy with or without bevacizumab was approved as the first-line treatment for recurrent and metastatic cervical cancer. Also tisotumab vedotin was approved as the second-line immunotherapy for r/m cervical cancer. Moreover, a plethora of clinical immunotherapy trials were approved in different countries, and some received as breakthrough therapy designations. Pembrolizumab, cemiplimab, atezolizumab, cadonilimab, zimberelimab, balstilimab and zalifrelimab, nivolumab, and tisotumab vedotin were reviewed with overall survival, progression-free survival, rate of objective response and adverse effects in order to review the efficacy and safety of different therapeutic option. Conclusions : The majority of trials indicated that immunotherapy can significantly improve the overall survival (OS) and progression-free survival (PFS) of r/m cervical cancer patients without negatively affecting health-related quality-of-life (HRQoL), and demonstrated that immunotherapy is an effective and safe treatment for r/m cervical cancer.","PeriodicalId":505527,"journal":{"name":"Clinical and Experimental Obstetrics & Gynecology","volume":"123 13","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141656868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The Role of Hysteroscopic Treatment in Cesarean Scar Pregnancy Management: An Advancement in Care","authors":"F. Gulino, Stefano Cianci, G. G. Incognito","doi":"10.31083/j.ceog5107154","DOIUrl":"https://doi.org/10.31083/j.ceog5107154","url":null,"abstract":"","PeriodicalId":505527,"journal":{"name":"Clinical and Experimental Obstetrics & Gynecology","volume":"40 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141658426","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background : Pregnant women exhibit an increased demand for nutrients, including vitamins, and a deficiency in vitamins can increase the risk of various pregnancy-related diseases. This study aims to evaluate the vitamin levels in women of different age groups and gestational stages in order to provide targeted dietary guidance and vitamin supplementation strategies. Methods : Pregnant women who registered and attended regular prenatal check-ups at Hangzhou Women’s Hospital from January to December 2021 were selected as study participants. Ultrahigh-performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS) was used to quantitatively determine the concentrations of vitamins A, D, E, K, B1, B2, B9 (folic acid), and B12 in the serum. Results : The serum vitamin A, B1, and B9 levels decreased with gestational age in the age-matched group, while the vitamin E level increased slightly ( p < 0.05). In the advanced-aged group, the levels of vitamins A, B1, B2, and B9 decreased with gestational age, but the levels of vitamins D3, E, K, and B12 slightly increased ( p < 0.05). In mid-pregnancy, age-matched women had slightly greater serum levels of vitamins E and K than did women in the advanced-aged group (Z = –2.67, p = 0.008; Z = –2.46, p = 0.014). In late pregnancy, significant differences existed in the serum levels of vitamins B2 and B12 between the two age groups (Z = –2.67, p = 0.008; Z = –2.50, p = 0.013). Conclusions : Vitamin levels varied by gestational stage and age during pregnancy, suggesting that vitamin supplementation should be individualized and stage-adjusted to improve maternal and child health.
{"title":"Analysis of Differences in the Serum Levels of Various Vitamins During Pregnancy: Effects of Gestational Stage and Age","authors":"Fangyuan Zheng, Pei He","doi":"10.31083/j.ceog5107152","DOIUrl":"https://doi.org/10.31083/j.ceog5107152","url":null,"abstract":"Background : Pregnant women exhibit an increased demand for nutrients, including vitamins, and a deficiency in vitamins can increase the risk of various pregnancy-related diseases. This study aims to evaluate the vitamin levels in women of different age groups and gestational stages in order to provide targeted dietary guidance and vitamin supplementation strategies. Methods : Pregnant women who registered and attended regular prenatal check-ups at Hangzhou Women’s Hospital from January to December 2021 were selected as study participants. Ultrahigh-performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS) was used to quantitatively determine the concentrations of vitamins A, D, E, K, B1, B2, B9 (folic acid), and B12 in the serum. Results : The serum vitamin A, B1, and B9 levels decreased with gestational age in the age-matched group, while the vitamin E level increased slightly ( p < 0.05). In the advanced-aged group, the levels of vitamins A, B1, B2, and B9 decreased with gestational age, but the levels of vitamins D3, E, K, and B12 slightly increased ( p < 0.05). In mid-pregnancy, age-matched women had slightly greater serum levels of vitamins E and K than did women in the advanced-aged group (Z = –2.67, p = 0.008; Z = –2.46, p = 0.014). In late pregnancy, significant differences existed in the serum levels of vitamins B2 and B12 between the two age groups (Z = –2.67, p = 0.008; Z = –2.50, p = 0.013). Conclusions : Vitamin levels varied by gestational stage and age during pregnancy, suggesting that vitamin supplementation should be individualized and stage-adjusted to improve maternal and child health.","PeriodicalId":505527,"journal":{"name":"Clinical and Experimental Obstetrics & Gynecology","volume":"95 15","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141657980","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background : To comprehensively investigate the diagnostic effect of intraoperative indocyanine green (ICG) imaging for endometriosis (EMs). Methods : We systematically retrieved relevant literature from a series of databases (Embase, Web of Science, PubMed, Clinical Trials, Cochrane Library, Chinese National Knowledge Infrastructure (CNKI), and WanFang Database) up to January 2024. We also performed manual searches using the reference lists from selected articles, along with reports from relevant meetings and Google Scholar. Data were stored and analyzed by Review Manager version 5.3 and Stata/MP version 14.0. Results : Systematic searches of the literature identified six articles comparing the diagnostic effect of ICG imaging to white light (WL) imaging for EMs during laparoscopic surgery. Two of these studies found that ICG imaging improved the diagnostic rate of EMs while the remaining four studies reported that the diagnostic value of ICG imaging was minimal. Cumulative analysis determined that the sensitivity was 0.88 (95% confidence interval [95% CI]: 0.81–0.93) for WL and 0.64 (95% CI: 0.36–0.84) for ICG. The specificity was 0.85 (95% CI: 0.49–0.97) for WL and 0.88 (95% CI: 0.66–0.97) for ICG. The positive likelihood ratio (LR+) was 5.8 (95% CI: 1.4–24.5) for WL and 5.4 (95% CI: 1.2–24.1) for ICG. The negative likelihood ratio (LR–) was 0.14 (95% CI: 0.09–0.20) for WL and 0.41 (95% CI: 0.18–0.94) for ICG, while the diagnostic odds ratio (DOR) was 42 (95% CI: 10–182) for WL and 13 (95% CI: 1–124) for ICG. Conclusions : Although we only analyzed a limited number of publications, our analysis demonstrated that ICG may be helpful for the visualization of occult EMs, although the diagnostic effect of ICG is not superior to WL. Our findings need to be confirmed by additional studies involving larger sample sizes from multiple centers.
{"title":"The Diagnostic Effect of Intraoperative Indocyanine Green Imaging for Endometriosis: A Systematic Review and Meta-Analysis","authors":"Zhuang Yuan, Honghui Ou, Yue Xu, Hua Yang","doi":"10.31083/j.ceog5107153","DOIUrl":"https://doi.org/10.31083/j.ceog5107153","url":null,"abstract":"Background : To comprehensively investigate the diagnostic effect of intraoperative indocyanine green (ICG) imaging for endometriosis (EMs). Methods : We systematically retrieved relevant literature from a series of databases (Embase, Web of Science, PubMed, Clinical Trials, Cochrane Library, Chinese National Knowledge Infrastructure (CNKI), and WanFang Database) up to January 2024. We also performed manual searches using the reference lists from selected articles, along with reports from relevant meetings and Google Scholar. Data were stored and analyzed by Review Manager version 5.3 and Stata/MP version 14.0. Results : Systematic searches of the literature identified six articles comparing the diagnostic effect of ICG imaging to white light (WL) imaging for EMs during laparoscopic surgery. Two of these studies found that ICG imaging improved the diagnostic rate of EMs while the remaining four studies reported that the diagnostic value of ICG imaging was minimal. Cumulative analysis determined that the sensitivity was 0.88 (95% confidence interval [95% CI]: 0.81–0.93) for WL and 0.64 (95% CI: 0.36–0.84) for ICG. The specificity was 0.85 (95% CI: 0.49–0.97) for WL and 0.88 (95% CI: 0.66–0.97) for ICG. The positive likelihood ratio (LR+) was 5.8 (95% CI: 1.4–24.5) for WL and 5.4 (95% CI: 1.2–24.1) for ICG. The negative likelihood ratio (LR–) was 0.14 (95% CI: 0.09–0.20) for WL and 0.41 (95% CI: 0.18–0.94) for ICG, while the diagnostic odds ratio (DOR) was 42 (95% CI: 10–182) for WL and 13 (95% CI: 1–124) for ICG. Conclusions : Although we only analyzed a limited number of publications, our analysis demonstrated that ICG may be helpful for the visualization of occult EMs, although the diagnostic effect of ICG is not superior to WL. Our findings need to be confirmed by additional studies involving larger sample sizes from multiple centers.","PeriodicalId":505527,"journal":{"name":"Clinical and Experimental Obstetrics & Gynecology","volume":"109 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141657401","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Karima Moumane, Ali Idri, Fatiha El Aouni, Jihad Laghnimi, N. C. Benabdellah, Oussama Hamal
Background : Mobile applications play a crucial role in postnatal, contraception, and prenatal care, offering vital monitoring and resources for mothers and infants. This study assessed the software product quality (SPQ) (the degree to which a software product meets specified requirements and user expectations) of three reproductive health monitoring mobile applications, employing ISO/IEC 25010 and ISO/IEC 25023 standards. The objective was to analyze the strengths and weaknesses of each app, thereby providing valuable information for potential users. By identifying areas requiring enhancement, this study improves the overall quality and usability of these applications. Methods : We implemented a three-step analysis process, examining the sub-features and features outlined in the ISO/IEC 25010 standard for software product quality, encompassing functionality, reliability, usability, efficiency, and maintainability. Subsequently, we formulated a checklist summarizing the influence of the three mobile applications on SPQ. Finally, we calculated the impact of each requirement block on both SPQ and quality in use (QIU) models. Results : The results show that the functional suitability SPQ characteristic is greatly influenced by the predefined requirements, with subsequent impacts on the operability, performance efficiency, reliability, and security SPQ characteristics. Thus, developers, designers, and testers must integrate these requirements across the developmental stages of health mobile applications to create a high-quality, patient-centered product with substantial added value. Conclusions : This study has produced a range of requirements tailored for pregnancy monitoring and childcare applications, serving as a valuable reference for developers aiming to create high-quality applications and evaluate their quality effectively. It underscores the importance of integrating SPQ characteristics into the software development process to ensure the creation of high-quality products with essential key performance indicators (KPIs). Such considerations facilitate better evaluations in application stores and increase user adoption and satisfaction levels.
{"title":"ISO/IEC 25010-based Quality Evaluation of Three Mobile Applications for Reproductive Health Services in Morocco","authors":"Karima Moumane, Ali Idri, Fatiha El Aouni, Jihad Laghnimi, N. C. Benabdellah, Oussama Hamal","doi":"10.31083/j.ceog5104088","DOIUrl":"https://doi.org/10.31083/j.ceog5104088","url":null,"abstract":"Background : Mobile applications play a crucial role in postnatal, contraception, and prenatal care, offering vital monitoring and resources for mothers and infants. This study assessed the software product quality (SPQ) (the degree to which a software product meets specified requirements and user expectations) of three reproductive health monitoring mobile applications, employing ISO/IEC 25010 and ISO/IEC 25023 standards. The objective was to analyze the strengths and weaknesses of each app, thereby providing valuable information for potential users. By identifying areas requiring enhancement, this study improves the overall quality and usability of these applications. Methods : We implemented a three-step analysis process, examining the sub-features and features outlined in the ISO/IEC 25010 standard for software product quality, encompassing functionality, reliability, usability, efficiency, and maintainability. Subsequently, we formulated a checklist summarizing the influence of the three mobile applications on SPQ. Finally, we calculated the impact of each requirement block on both SPQ and quality in use (QIU) models. Results : The results show that the functional suitability SPQ characteristic is greatly influenced by the predefined requirements, with subsequent impacts on the operability, performance efficiency, reliability, and security SPQ characteristics. Thus, developers, designers, and testers must integrate these requirements across the developmental stages of health mobile applications to create a high-quality, patient-centered product with substantial added value. Conclusions : This study has produced a range of requirements tailored for pregnancy monitoring and childcare applications, serving as a valuable reference for developers aiming to create high-quality applications and evaluate their quality effectively. It underscores the importance of integrating SPQ characteristics into the software development process to ensure the creation of high-quality products with essential key performance indicators (KPIs). Such considerations facilitate better evaluations in application stores and increase user adoption and satisfaction levels.","PeriodicalId":505527,"journal":{"name":"Clinical and Experimental Obstetrics & Gynecology","volume":"10 11","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140366788","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Geoffrey D Towers, Dani G. Zoorob, Rose A. Maxwell, Ashley N. Reid, J. Yaklic, Jason C. Massengill
{"title":"Objective Assessment of Rupture Parameters in Intact and Acute Post-Cystorrhaphy Cadaveric Bladders","authors":"Geoffrey D Towers, Dani G. Zoorob, Rose A. Maxwell, Ashley N. Reid, J. Yaklic, Jason C. Massengill","doi":"10.31083/j.ceog5104085","DOIUrl":"https://doi.org/10.31083/j.ceog5104085","url":null,"abstract":"","PeriodicalId":505527,"journal":{"name":"Clinical and Experimental Obstetrics & Gynecology","volume":"21 7","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140375833","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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