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I saw the swirl sign: Acute extravasation of blood within a hematoma 我看到了漩涡征象:血肿内血液急性外渗
IF 2.1 4区 医学 Q2 Medicine Pub Date : 2024-05-25 DOI: 10.1016/j.clinimag.2024.110195
Mina B. Botros , Ajit S. Puri , Jasmeet Singh , Anna Luisa Kuhn

The swirl sign is a finding on non-contrast computed tomography (CT) scans that represents an acute extravasation of blood into a hematoma filled with clotted blood. In it, a “swirl” of active bleeding within a body of acutely clotted blood is noted as a hypodense accumulation within a hyperdense fluid collection. Here, we describe a case in which a 35-year-old female presents unresponsive with a Glasgow Coma Scale score of 3 and is ultimately found to have a large frontal intraparenchymal hematoma with intraventricular extension and an area of low attenuation within the hyperattenuating fluid collection on CT, otherwise known as the swirl sign. This radiographic sign has been associated with hematoma expansion, worse clinical outcomes as measured by the Glasgow Outcome Scale, and higher mortality rates. As such, all patients suspected to have intracranial bleeds should have CT imaging done as soon as possible. When the swirl sign is identified on CT, providers are clued in to the risk of clinical deterioration and the urgent need for surgical evaluation.

漩涡征是一种非对比计算机断层扫描(CT)发现的征象,代表血液急性外渗到充满凝血的血肿中。在漩涡征中,急性凝血块内的活动性出血 "漩涡 "表现为高密度积液中的低密度积液。在这里,我们描述了这样一个病例:一名 35 岁的女性出现反应迟钝,格拉斯哥昏迷量表评分为 3 分,最终在 CT 上被发现有一个大的额部实质内血肿,并伴有脑室内扩展,在高衰减的液体聚集内有一个低衰减区,也就是所谓的漩涡征。这种影像学征象与血肿扩大、格拉斯哥结果量表(Glasgow Outcome Scale)显示的更差的临床结果和更高的死亡率有关。因此,所有疑似颅内出血的患者都应尽快进行 CT 成像检查。一旦在 CT 上发现漩涡征,医疗人员就会意识到临床恶化的风险和手术评估的紧迫性。
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引用次数: 0
Evaluation of responses to cardiac imaging questions by the artificial intelligence large language model ChatGPT 人工智能大型语言模型 ChatGPT 对心脏成像问题回答的评估
IF 2.1 4区 医学 Q2 Medicine Pub Date : 2024-05-23 DOI: 10.1016/j.clinimag.2024.110193
Cynthia L. Monroe , Yasser G. Abdelhafez , Kwame Atsina , Edris Aman , Lorenzo Nardo , Mohammad H. Madani

Purpose

To assess ChatGPT's ability as a resource for educating patients on various aspects of cardiac imaging, including diagnosis, imaging modalities, indications, interpretation of radiology reports, and management.

Methods

30 questions were posed to ChatGPT-3.5 and ChatGPT-4 three times in three separate chat sessions. Responses were scored as correct, incorrect, or clinically misleading categories by three observers—two board certified cardiologists and one board certified radiologist with cardiac imaging subspecialization. Consistency of responses across the three sessions was also evaluated. Final categorization was based on majority vote between at least two of the three observers.

Results

ChatGPT-3.5 answered seventeen of twenty eight questions correctly (61 %) by majority vote. Twenty one of twenty eight questions were answered correctly (75 %) by ChatGPT-4 by majority vote. Majority vote for correctness was not achieved for two questions. Twenty six of thirty questions were answered consistently by ChatGPT-3.5 (87 %). Twenty nine of thirty questions were answered consistently by ChatGPT-4 (97 %). ChatGPT-3.5 had both consistent and correct responses to seventeen of twenty eight questions (61 %). ChatGPT-4 had both consistent and correct responses to twenty of twenty eight questions (71 %).

Conclusion

ChatGPT-4 had overall better performance than ChatGTP-3.5 when answering cardiac imaging questions with regard to correctness and consistency of responses. While both ChatGPT-3.5 and ChatGPT-4 answers over half of cardiac imaging questions correctly, inaccurate, clinically misleading and inconsistent responses suggest the need for further refinement before its application for educating patients about cardiac imaging.

目的 评估 ChatGPT 作为向患者讲解心脏成像各方面知识的资源的能力,包括诊断、成像方式、适应症、放射学报告的解释和管理。方法 在三个独立的聊天会话中,向 ChatGPT-3.5 和 ChatGPT-4 提出了 30 个问题。回答分为正确、错误或临床误导三类,由三名观察员进行评分,其中两名是获得医学会认证的心脏病专家,一名是获得医学会认证的放射科专家,他们都拥有心脏成像亚专业资质。此外,还对三个环节中回答的一致性进行了评估。结果 ChatGPT-3.5 以多数票正确回答了二十八个问题中的十七个(61%)。ChatGPT-4 以多数票正确回答了二十八个问题中的二十一个(75%)。有两个问题的正确率没有达到多数票。在 ChatGPT-3.5 中,30 个问题中有 26 个问题得到了一致回答(87%)。ChatGPT-4 对 30 个问题中的 29 个问题进行了一致回答(97%)。ChatGPT-3.5 对 28 个问题中的 17 个问题(61%)的回答既一致又正确。结论在回答心脏成像问题时,ChatGPT-4 在回答的正确性和一致性方面的整体表现优于 ChatGTP-3.5。虽然 ChatGPT-3.5 和 ChatGPT-4 都能正确回答一半以上的心脏成像问题,但不准确、误导临床和不一致的回答表明,在应用 ChatGPT-4 对患者进行心脏成像教育之前,有必要对其进行进一步改进。
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引用次数: 0
More is missed by not looking – incidental findings on FDG-PET 不看就会错过更多--FDG-PET 的偶然发现
IF 2.1 4区 医学 Q2 Medicine Pub Date : 2024-05-16 DOI: 10.1016/j.clinimag.2024.110186
Joseph C. Lee , Jia Wen Chong , Gemma F. Hartnett
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引用次数: 0
Evaluation of radiology resident well-being at a single institution with a dedicated wellness curriculum 在一家设有专门健康课程的机构对放射科住院医师的健康状况进行评估
IF 2.1 4区 医学 Q2 Medicine Pub Date : 2024-05-16 DOI: 10.1016/j.clinimag.2024.110184
Jenifer Pitman , Juliana Atallah , Connie Lu , Zoe Verzani , Andrew Schweitzer , Robert J. Min , Lily Belfi

Introduction

Increasing rates of physician burnout over recent years have resulted in the need for formal tools and programming dedicated to physician well-being. The Accreditation Council for Graduate Medical Education (ACGME) has taken measures to prioritize trainee well-being by revising its common program requirements. Widespread departmental initiatives have been developed in line with these changes. At the authors' institution, a committee was developed to design and implement a holistic wellness curriculum for radiology trainees.

Objective

The objective of this study was to assess overall well-being in a cohort of radiology residents at a training program with a dedicated wellness curriculum.

Methods

A wellness curriculum for radiology residents was developed and implemented. Over a 3-year period, data was collected using the Maslach Burnout Inventory (MBI), Brief Resilience Scale (BRS).

Results

Rates amongst respondents were low, compared to average, for emotional exhaustion (below 17, average 25.2), depersonalization (6, average 10), and of personal accomplishment were moderate to high (37.5, average 32.9). PGY-4 level residents had the highest rates of burnout (p = 0.042 for depersonalization, p = 0.006 for emotional exhaustion). PGY-4 residents also had the lowest rates of resilience based on the BRS, and PGY-3 the highest (p = 0.037). There were no statistically significant differences between gender or differing relationship status for MBI or BRS. The most commonly cited barriers to wellness practices included fatigue, competing responsibilities, and not knowing where to start.

Conclusion

Radiology residents at a single institution with a dedicated wellness curriculum demonstrated overall lower rates of burnout compared to their peers.

导言近年来,医生职业倦怠率不断上升,因此需要有专门针对医生身心健康的正式工具和计划。美国毕业后医学教育认证委员会(ACGME)已采取措施,通过修订其共同项目要求,优先考虑受训者的身心健康。根据这些变化,各部门已广泛开展了相关活动。在作者所在的机构,成立了一个委员会,负责为放射科学员设计和实施整体健康课程。本研究的目的是评估一个培训项目中放射科住院医师群体的整体健康状况,该培训项目设有专门的健康课程。方法制定并实施了放射科住院医师健康课程。结果与平均水平相比,受访者在情绪衰竭(低于17分,平均25.2分)、人格解体(6分,平均10分)和个人成就感(37.5分,平均32.9分)方面的得分较低,而在中高水平(37.5分,平均32.9分)方面的得分较高。PGY-4 级住院医师的职业倦怠率最高(人格解体 p = 0.042,情感衰竭 p = 0.006)。根据 BRS,PGY-4 级住院医师的抗压能力最低,PGY-3 级最高(p = 0.037)。就 MBI 或 BRS 而言,不同性别或不同关系状况之间的差异在统计学上并不明显。最常提到的健康实践障碍包括疲劳、相互竞争的责任以及不知从何入手。
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引用次数: 0
Image-guided percutaneous strategies to improve the resectability of HCC: Portal vein embolization, liver venous deprivation, or radiation lobectomy? 图像引导下的经皮策略可提高 HCC 的切除率:门静脉栓塞术、肝静脉剥夺术还是放射肝叶切除术?
IF 2.1 4区 医学 Q2 Medicine Pub Date : 2024-05-13 DOI: 10.1016/j.clinimag.2024.110185
Shin Mei Chan , Joshua Cornman-Homonoff , Pierleone Lucatelli , David C. Madoff

Despite considerable advances in surgical technique, many patients with hepatic malignancies are not operative candidates due to projected inadequate hepatic function following resection. Consequently, the size of the future liver remnant (FLR) is an essential consideration when predicting a patient's likelihood of liver insufficiency following hepatectomy. Since its initial description 30 years ago, portal vein embolization has become the standard of care for augmenting the size and function of the FLR preoperatively. However, new minimally invasive techniques have been developed to improve surgical candidacy, chief among them liver venous deprivation and radiation lobectomy. The purpose of this review is to discuss the status of preoperative liver augmentation prior to resection of hepatocellular carcinoma with a focus on these three techniques, highlighting the distinctions between them and suggesting directions for future investigation.

尽管手术技术有了长足的进步,但许多肝脏恶性肿瘤患者由于预计切除术后肝功能不全而无法接受手术。因此,在预测患者肝切除术后肝功能不全的可能性时,未来肝脏残余(FLR)的大小是一个重要的考虑因素。自 30 年前首次提出门静脉栓塞术以来,门静脉栓塞术已成为术前增加残肝大小和功能的标准治疗方法。然而,新的微创技术已经发展起来,以改善手术适应症,其中最主要的是肝静脉剥夺术和放射肝叶切除术。本综述旨在讨论肝细胞癌切除术前肝脏增大术的现状,重点关注这三种技术,强调它们之间的区别,并提出未来的研究方向。
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引用次数: 0
A teleradiology network for the improvement of healthcare and patient management in the developing countries of the African continent 远程放射学网络,改善非洲大陆发展中国家的医疗保健和病人管理
IF 2.1 4区 医学 Q2 Medicine Pub Date : 2024-05-10 DOI: 10.1016/j.clinimag.2024.110188
Katelyn E. Rudisill , Neetika Mathur , Arjun Kalyanpur

Introduction

Africa is the second-largest continent on Earth in terms of both size and population. However, inaccessibility and shortfall of trained radiologists impede the delivery of adequate healthcare to such a large population. Teleradiology holds considerable potential in improving patient outcomes and healthcare delivery in African nations by furnishing timely interpretation of radiological examinations, particularly in those areas where there is a particular scarcity of radiologists. The aim of the present study was to assess the impact of teleradiology in the improvement of healthcare and patient management in the developing countries of the African continent.

Methods

In this retrospective study, from January 2017 and December 2022, the scans of a cohort of patients from eight African countries were uploaded to the teleradiology cloud server and interpreted by board certified radiologists empanelled by a teleradiology service provider.

Results

The telehealth model proposed in the study was seen to provide timely and quality reporting of 58,223 scans of 39,513 patients with a mean turn-around-time (TAT) of 2.46 h 95 % CI (2.44–2.48).

Discussion

A dedicated teleradiology model designed in this study allowed the interpretation and analysis of the scans of the cohort of patients from hospitals in African countries by teleradiologists via high quality DICOM-image transfer over a cloud-based platform. The outcomes of our investigation reflect that teleradiology provides an effective solution for early diagnosis/interpretation of examinations performed in Africa. Further, the currently proposed teleradiology model may be used for other developing countries across the world to improve quality of care.

导言就面积和人口而言,非洲是地球上第二大洲。然而,交通不便和训练有素的放射科医生短缺阻碍了为如此庞大的人口提供充分的医疗保健服务。远程放射学通过及时解读放射检查结果,在改善非洲国家患者的治疗效果和医疗服务方面具有相当大的潜力,尤其是在那些放射科医生特别缺乏的地区。本研究旨在评估远程放射学在改善非洲大陆发展中国家医疗保健和患者管理方面的影响。方法在这项回顾性研究中,从 2017 年 1 月到 2022 年 12 月,来自 8 个非洲国家的一组患者的扫描结果被上传到远程放射学云服务器,并由远程放射学服务提供商授权的经认证的放射科医师进行解读。讨论本研究中设计的专用远程放射学模式允许远程放射学专家通过云平台上的高质量 DICOM 图像传输,对来自非洲国家医院的一组患者的扫描结果进行解读和分析。我们的调查结果表明,远程放射学为在非洲进行的早期诊断/解释检查提供了有效的解决方案。此外,目前提出的远程放射学模式也可用于全球其他发展中国家,以提高医疗质量。
{"title":"A teleradiology network for the improvement of healthcare and patient management in the developing countries of the African continent","authors":"Katelyn E. Rudisill ,&nbsp;Neetika Mathur ,&nbsp;Arjun Kalyanpur","doi":"10.1016/j.clinimag.2024.110188","DOIUrl":"https://doi.org/10.1016/j.clinimag.2024.110188","url":null,"abstract":"<div><h3>Introduction</h3><p>Africa is the second-largest continent on Earth in terms of both size and population. However, inaccessibility and shortfall of trained radiologists impede the delivery of adequate healthcare to such a large population. Teleradiology holds considerable potential in improving patient outcomes and healthcare delivery in African nations by furnishing timely interpretation of radiological examinations, particularly in those areas where there is a particular scarcity of radiologists. The aim of the present study was to assess the impact of teleradiology in the improvement of healthcare and patient management in the developing countries of the African continent.</p></div><div><h3>Methods</h3><p>In this retrospective study, from January 2017 and December 2022, the scans of a cohort of patients from eight African countries were uploaded to the teleradiology cloud server and interpreted by board certified radiologists empanelled by a teleradiology service provider.</p></div><div><h3>Results</h3><p>The telehealth model proposed in the study was seen to provide timely and quality reporting of 58,223 scans of 39,513 patients with a mean turn-around-time (TAT) of 2.46 h 95 % CI (2.44–2.48).</p></div><div><h3>Discussion</h3><p>A dedicated teleradiology model designed in this study allowed the interpretation and analysis of the scans of the cohort of patients from hospitals in African countries by teleradiologists via high quality DICOM-image transfer over a cloud-based platform. The outcomes of our investigation reflect that teleradiology provides an effective solution for early diagnosis/interpretation of examinations performed in Africa. Further, the currently proposed teleradiology model may be used for other developing countries across the world to improve quality of care.</p></div>","PeriodicalId":50680,"journal":{"name":"Clinical Imaging","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2024-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140952279","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Partial visualization of appendix on ultrasound: What does it mean in the child with suspected appendicitis? 超声波可看到部分阑尾:对疑似阑尾炎患儿意味着什么?
IF 2.1 4区 医学 Q2 Medicine Pub Date : 2024-05-10 DOI: 10.1016/j.clinimag.2024.110187
Pradipta Debnath , Andrew T. Trout , Rama S. Ayyala

Background

Visualization of the entire appendix, including the tip, is thought, but has not been demonstrated, to be important for exclusion of appendicitis by ultrasound.

Objective

To determine if incomplete visualization of the appendix has negative clinical ramifications including missed appendicitis.

Methods

Under IRB approval we retrospectively reviewed right lower quadrant ultrasound reports from January 2017 to December 2020 to identify examinations with impressions of full visualization of the normal appendix, non-visualization of the appendix with and without secondary findings of appendicitis, and partial visualization of the appendix. Electronic health records were reviewed for follow-up imaging within 48 h, and surgery with pathology reports (if available).

Results

12,193 examinations were included. 4171 (34.2 %) had full visualization of a normal appendix, 5369 (44.0 %) had non-visualization with no secondary findings, and 234 (1.9 %) had non-visualization with secondary findings, The frequencies of appendicitis in these three groups were 34 (0.8 %), 283 (5.3 %), and 127 (54.3 %) respectively.

The appendix was partially visualized in 338 (2.8 %) patients with secondary findings present in 53 (15.6 %). Partial visualization without secondary findings had a similar frequency (4.9 %, 14/285) of appendicitis to non-visualized appendix without secondary findings (p = 0.797) and a higher frequency than full visualization of a normal appendix (p < 0.0001). Partial visualization with secondary findings had similar rates (54.7 %, 29/53) to non-visualized appendix with secondary findings (p = 0.953).

Conclusion

Partial visualization of the appendix with ultrasound (with and without secondary findings) is associated with similar frequencies of appendicitis as non-visualization of appendix (with and without secondary findings).

背景人们认为,包括阑尾顶端在内的整个阑尾的可视化对于通过超声排除阑尾炎非常重要,但尚未得到证实。目的确定阑尾的不完全可视化是否会产生负面的临床影响,包括漏诊阑尾炎。方法 经 IRB 批准,我们回顾性审查了 2017 年 1 月至 2020 年 12 月期间的右下腹超声波报告,以确定正常阑尾完全显影、阑尾未显影且有或无阑尾炎继发结果以及阑尾部分显影的检查印象。对 48 小时内的后续成像和手术病理报告(如有)的电子健康记录进行了审查。4171例(34.2%)阑尾完全显影正常,5369例(44.0%)阑尾未显影且无继发性发现,234例(1.9%)阑尾未显影且有继发性发现,这三类患者中阑尾炎的发生率分别为34例(0.8%)、283例(5.3%)和127例(54.3%)。部分显示阑尾但无继发性发现的阑尾炎发病率(4.9%,14/285)与未显示阑尾但无继发性发现的阑尾炎发病率相似(p = 0.797),但高于完全显示正常阑尾的阑尾炎发病率(p <0.0001)。结论超声部分显示阑尾(显示或未显示阑尾)与未显示阑尾(显示或未显示阑尾)发生阑尾炎的频率相似。
{"title":"Partial visualization of appendix on ultrasound: What does it mean in the child with suspected appendicitis?","authors":"Pradipta Debnath ,&nbsp;Andrew T. Trout ,&nbsp;Rama S. Ayyala","doi":"10.1016/j.clinimag.2024.110187","DOIUrl":"https://doi.org/10.1016/j.clinimag.2024.110187","url":null,"abstract":"<div><h3>Background</h3><p>Visualization of the entire appendix, including the tip, is thought, but has not been demonstrated, to be important for exclusion of appendicitis by ultrasound.</p></div><div><h3>Objective</h3><p>To determine if incomplete visualization of the appendix has negative clinical ramifications including missed appendicitis.</p></div><div><h3>Methods</h3><p>Under IRB approval we retrospectively reviewed right lower quadrant ultrasound reports from January 2017 to December 2020 to identify examinations with impressions of full visualization of the normal appendix, non-visualization of the appendix with and without secondary findings of appendicitis, and partial visualization of the appendix. Electronic health records were reviewed for follow-up imaging within 48 h, and surgery with pathology reports (if available).</p></div><div><h3>Results</h3><p>12,193 examinations were included. 4171 (34.2 %) had full visualization of a normal appendix, 5369 (44.0 %) had non-visualization with no secondary findings, and 234 (1.9 %) had non-visualization with secondary findings, The frequencies of appendicitis in these three groups were 34 (0.8 %), 283 (5.3 %), and 127 (54.3 %) respectively.</p><p>The appendix was partially visualized in 338 (2.8 %) patients with secondary findings present in 53 (15.6 %). Partial visualization without secondary findings had a similar frequency (4.9 %, 14/285) of appendicitis to non-visualized appendix without secondary findings (<em>p</em> = 0.797) and a higher frequency than full visualization of a normal appendix (<em>p</em> &lt; 0.0001). Partial visualization with secondary findings had similar rates (54.7 %, 29/53) to non-visualized appendix with secondary findings (<em>p</em> = 0.953).</p></div><div><h3>Conclusion</h3><p>Partial visualization of the appendix with ultrasound (with and without secondary findings) is associated with similar frequencies of appendicitis as non-visualization of appendix (with and without secondary findings).</p></div>","PeriodicalId":50680,"journal":{"name":"Clinical Imaging","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2024-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140947870","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Breast cancer screening in BRCA1/2 pathogenic sequence variant carriers during pregnancy and lactation 孕期和哺乳期 BRCA1/2 致病序列变异携带者的乳腺癌筛查
IF 2.1 4区 医学 Q2 Medicine Pub Date : 2024-05-10 DOI: 10.1016/j.clinimag.2024.110189
Vera Sorin , Hila Bufman , Rinat Bernstein-Molho , Renata Faermann , Eitan Friedman , Daniel Raskin , Nora Balint Lahat , Miri Sklair-Levy

Objectives

Women harboring germline BRCA1/BRCA2 pathogenic sequence variants (PSVs) are at an increased risk for breast cancer. There are no established guidelines for screening during pregnancy and lactation in BRCA carriers. The aim of this study was to evaluate the utility of whole-breast ultrasound (US) screening in pregnant and lactating BRCA PSV carriers.

Methods

Data were retrospectively collected from medical records of BRCA PSV carriers between 2014 and 2020, with follow-up until 2021. Associations between imaging intervals, number of examinations performed and pregnancy-associated breast cancers (PABCs) were examined. PABCs and cancers diagnosed at follow-up were evaluated and characteristics were compared between the two groups.

Results

Overall 212 BRCA PSV carriers were included. Mean age was 33.6 years (SD 3.93, range 25–43 years). During 274 screening periods at pregnancy and lactation, eight (2.9 %) PABCs were diagnosed. An additional eight cancers were diagnosed at follow-up. Three out of eight (37.5 %) PABCs were diagnosed by US, whereas clinical breast examination (n = 3), mammography (n = 1) and MRI (n = 1) accounted for the other PACB diagnoses. One PABC was missed by US. The interval from negative imaging to cancer diagnosis was significantly shorter for PABCs compared with cancers diagnosed at follow-up (3.96 ± 2.14 vs. 11.2 ± 4.46 months, P = 0.002).

Conclusion

In conclusion, pregnant BRCA PSV carriers should not delay screening despite challenges like altered breast tissue and hesitancy towards mammography. If no alternatives exist, whole-breast ultrasound can be used. For lactating and postpartum women, a regular screening routine alternating between mammography and MRI is recommended.

目标携带种系 BRCA1/BRCA2 致病序列变异(PSV)的妇女罹患乳腺癌的风险增加。目前尚无针对 BRCA 携带者孕期和哺乳期筛查的既定指南。本研究旨在评估对妊娠期和哺乳期 BRCA PSV 携带者进行全乳腺超声(US)筛查的效用。方法回顾性收集 2014 年至 2020 年期间 BRCA PSV 携带者的病历数据,随访至 2021 年。研究了成像间隔、检查次数和妊娠相关乳腺癌(PABC)之间的关联。对随访期间确诊的 PABC 和癌症进行了评估,并对两组患者的特征进行了比较。平均年龄为 33.6 岁(SD 3.93,范围为 25-43 岁)。在怀孕和哺乳期的 274 次筛查中,有 8 例(2.9%)被诊断为 PABC。另有 8 例癌症是在随访时确诊的。在 8 例 PABC 中,有 3 例(37.5%)是通过 US 诊断出来的,而其他 PACB 的诊断方法包括临床乳房检查(3 例)、乳房 X 光检查(1 例)和核磁共振成像(1 例)。US 检查漏诊了 1 例 PABC。总之,尽管存在乳腺组织改变和对乳房 X 光检查犹豫不决等挑战,但 BRCA PSV 携带者孕妇不应推迟筛查。如果没有其他选择,可以采用全乳腺超声检查。对于哺乳期和产后妇女,建议定期进行乳房 X 线照相术和磁共振成像交替筛查。
{"title":"Breast cancer screening in BRCA1/2 pathogenic sequence variant carriers during pregnancy and lactation","authors":"Vera Sorin ,&nbsp;Hila Bufman ,&nbsp;Rinat Bernstein-Molho ,&nbsp;Renata Faermann ,&nbsp;Eitan Friedman ,&nbsp;Daniel Raskin ,&nbsp;Nora Balint Lahat ,&nbsp;Miri Sklair-Levy","doi":"10.1016/j.clinimag.2024.110189","DOIUrl":"https://doi.org/10.1016/j.clinimag.2024.110189","url":null,"abstract":"<div><h3>Objectives</h3><p>Women harboring germline BRCA1/BRCA2 pathogenic sequence variants (PSVs) are at an increased risk for breast cancer. There are no established guidelines for screening during pregnancy and lactation in BRCA carriers. The aim of this study was to evaluate the utility of whole-breast ultrasound (US) screening in pregnant and lactating BRCA PSV carriers.</p></div><div><h3>Methods</h3><p>Data were retrospectively collected from medical records of BRCA PSV carriers between 2014 and 2020, with follow-up until 2021. Associations between imaging intervals, number of examinations performed and pregnancy-associated breast cancers (PABCs) were examined. PABCs and cancers diagnosed at follow-up were evaluated and characteristics were compared between the two groups.</p></div><div><h3>Results</h3><p>Overall 212 BRCA PSV carriers were included. Mean age was 33.6 years (SD 3.93, range 25–43 years). During 274 screening periods at pregnancy and lactation, eight (2.9 %) PABCs were diagnosed. An additional eight cancers were diagnosed at follow-up. Three out of eight (37.5 %) PABCs were diagnosed by US, whereas clinical breast examination (<em>n</em> = 3), mammography (<em>n</em> = 1) and MRI (n = 1) accounted for the other PACB diagnoses. One PABC was missed by US. The interval from negative imaging to cancer diagnosis was significantly shorter for PABCs compared with cancers diagnosed at follow-up (3.96 ± 2.14 vs. 11.2 ± 4.46 months, <em>P</em> = 0.002).</p></div><div><h3>Conclusion</h3><p>In conclusion, pregnant BRCA PSV carriers should not delay screening despite challenges like altered breast tissue and hesitancy towards mammography. If no alternatives exist, whole-breast ultrasound can be used. For lactating and postpartum women, a regular screening routine alternating between mammography and MRI is recommended.</p></div>","PeriodicalId":50680,"journal":{"name":"Clinical Imaging","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2024-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140952280","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
I saw the ‘puff of smoke’ sign before it vanished into thin air 我看到了 "一阵烟 "的标志,然后它就消失得无影无踪了
IF 2.1 4区 医学 Q2 Medicine Pub Date : 2024-05-10 DOI: 10.1016/j.clinimag.2024.110190
Lyle Suh , Ajit S. Puri , Jasmeet Singh , Anna Luisa Kuhn

Moyamoya is characterized as a non-atherosclerotic and non-inflammatory vasculopathy that leads to progressive stenosis of the intracranial internal carotid arteries as well as the Circle of Willis. While it can be idiopathic (Moyamoya disease) or associated with another condition (Moyamoya syndrome), there is a characteristic ‘puff of smoke’ sign that can be appreciated on cerebral angiography.

莫亚莫亚症是一种非动脉粥样硬化性和非炎症性血管病变,会导致颅内颈内动脉和威利斯环进行性狭窄。虽然它可能是特发性的(Moyamoya 病),也可能与其他疾病(Moyamoya 综合征)相关,但在脑血管造影术中可以看到一种特征性的 "烟雾状 "征象。
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引用次数: 0
Yield of MR-directed US for MRI-detected breast findings: how often can we avoid MR biopsy? 针对磁共振成像检测到的乳腺结果进行磁共振定向 US 的收益率:多长时间可以避免磁共振活检?
IF 2.1 4区 医学 Q2 Medicine Pub Date : 2024-05-08 DOI: 10.1016/j.clinimag.2024.110174
Melissa Reichman , Xiaoxuan Chen , Annabel Lee , Julia Losner , Charlene Thomas , Janine Katzen

Purpose

To evaluate the yield of MR-directed ultrasound for MRI detected breast findings.

Methods

This retrospective study included 857 consecutive patients who had a breast MRI between January 2017–December 2020 and received a BI-RADS 4 assessment. Only exams recommended for MR-directed ultrasound were included in the study, yielding 765 patients. Findings were characterized by presence or absence of a sonographic correlate. Utilizing the electronic medical record, for those with a sonographic correlate, the size, location, and morphology were noted. Imaging guided (Ultrasound and MRI) pathology results as well as excisional pathology results were recorded. A multivariable logistical regression analysis was used to investigate the clinical utility of MR-directed ultrasound.

Results

There were 1262 MRI-detected BI-RADS category 4 findings in 765 patients. Of the 1262 findings, MR-directed ultrasound was performed on 852 (68 %). Of these, 291/852 (34 %) had an ultrasound correlate, including 143/291 (49 %) benign lesions, 81/291 (28 %) malignant lesions, 16/291 (5 %) with high-risk pathology and 51/291 (18 %) unknown due to lost to follow-up. Of those findings with ultrasound correlates, 173/291 (59 %) represented masses, 69/291 (24 %) were regions of non-mass enhancement, 22/291 (7.6 %) were foci and 27/291 (9.3 %) fell into the category of other which included lymph node, cysts, and scar tissue. Masses were significantly more likely to be identified on MR-directed ultrasound (p < 0.0001) compared to foci.

Conclusion

The yield of MR-directed ultrasound is significantly higher for masses, than foci and non-mass enhancement, which should be taken into consideration when recommending an MR-directed ultrasound.

目的评估磁共振成像检测到的乳腺结果的磁共振定向超声检查率。方法这项回顾性研究纳入了在 2017 年 1 月至 2020 年 12 月期间接受乳腺磁共振成像检查并接受 BI-RADS 4 评估的 857 名连续患者。只有建议进行磁共振引导超声检查的患者才被纳入研究,共纳入 765 名患者。检查结果以是否存在超声相关性为特征。利用电子病历,对有声像图相关结果的患者记录其大小、位置和形态。记录了成像引导(超声波和核磁共振成像)病理结果以及切除病理结果。结果765名患者中共有1262个MRI检测到的BI-RADS第4类结果。在这 1262 项检查结果中,有 852 项(68%)进行了磁共振定向超声检查。其中,291/852(34%)有超声相关性,包括143/291(49%)个良性病变、81/291(28%)个恶性病变、16/291(5%)个高危病变和51/291(18%)个因失去随访而未知的病变。在有超声相关性的检查结果中,173/291(59%)例为肿块,69/291(24%)例为非肿块强化区域,22/291(7.6%)例为病灶,27/291(9.3%)例为其他类别,包括淋巴结、囊肿和疤痕组织。结论 MR 导向超声检查发现肿块的几率明显高于病灶和非肿块增强,在建议进行 MR 导向超声检查时应考虑到这一点。
{"title":"Yield of MR-directed US for MRI-detected breast findings: how often can we avoid MR biopsy?","authors":"Melissa Reichman ,&nbsp;Xiaoxuan Chen ,&nbsp;Annabel Lee ,&nbsp;Julia Losner ,&nbsp;Charlene Thomas ,&nbsp;Janine Katzen","doi":"10.1016/j.clinimag.2024.110174","DOIUrl":"10.1016/j.clinimag.2024.110174","url":null,"abstract":"<div><h3>Purpose</h3><p>To evaluate the yield of MR-directed ultrasound for MRI detected breast findings.</p></div><div><h3>Methods</h3><p>This retrospective study included 857 consecutive patients who had a breast MRI between January 2017–December 2020 and received a BI-RADS 4 assessment. Only exams recommended for MR-directed ultrasound were included in the study, yielding 765 patients. Findings were characterized by presence or absence of a sonographic correlate. Utilizing the electronic medical record, for those with a sonographic correlate, the size, location, and morphology were noted. Imaging guided (Ultrasound and MRI) pathology results as well as excisional pathology results were recorded. A multivariable logistical regression analysis was used to investigate the clinical utility of MR-directed ultrasound.</p></div><div><h3>Results</h3><p>There were 1262 MRI-detected BI-RADS category 4 findings in 765 patients. Of the 1262 findings, MR-directed ultrasound was performed on 852 (68 %). Of these, 291/852 (34 %) had an ultrasound correlate, including 143/291 (49 %) benign lesions, 81/291 (28 %) malignant lesions, 16/291 (5 %) with high-risk pathology and 51/291 (18 %) unknown due to lost to follow-up. Of those findings with ultrasound correlates, 173/291 (59 %) represented masses, 69/291 (24 %) were regions of non-mass enhancement, 22/291 (7.6 %) were foci and 27/291 (9.3 %) fell into the category of other which included lymph node, cysts, and scar tissue. Masses were significantly more likely to be identified on MR-directed ultrasound (<em>p</em> &lt; 0.0001) compared to foci.</p></div><div><h3>Conclusion</h3><p>The yield of MR-directed ultrasound is significantly higher for masses, than foci and non-mass enhancement, which should be taken into consideration when recommending an MR-directed ultrasound.</p></div>","PeriodicalId":50680,"journal":{"name":"Clinical Imaging","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2024-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141024560","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
Clinical Imaging
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