Pub Date : 2024-12-01Epub Date: 2024-10-09DOI: 10.2215/CJN.0000000000000563
Michelle Tran, Chun Anna Xu, Jonathan Wilson, Rasheeda Hall, Patti L Ephraim, Tariq Shafi, Daniel E Weiner, Benjamin A Goldstein, Julia J Scialla
{"title":"Breast and Prostate Cancer Screening by Life Expectancy in Patients with Kidney Failure on Dialysis.","authors":"Michelle Tran, Chun Anna Xu, Jonathan Wilson, Rasheeda Hall, Patti L Ephraim, Tariq Shafi, Daniel E Weiner, Benjamin A Goldstein, Julia J Scialla","doi":"10.2215/CJN.0000000000000563","DOIUrl":"10.2215/CJN.0000000000000563","url":null,"abstract":"","PeriodicalId":50681,"journal":{"name":"Clinical Journal of the American Society of Nephrology","volume":" ","pages":"1537-1546"},"PeriodicalIF":8.5,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11637709/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142394955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-12-01Epub Date: 2024-09-20DOI: 10.2215/CJN.0000000593
Ana P Rossi, Goni Katz-Greenberg, Lisa Coscia, Carla W Brady, Christina Doligalski, Roxanna A Irani, Arthur Matas, Silvi Shah, Krista L Lentine
Living kidney donation and living liver donation significantly increases organ supply to make lifesaving transplants possible, offering survival benefits to the recipients and cost savings to society. Of all living donors, 40% are women of childbearing age. However, limited data exist regarding the effect of donation on future pregnancies and of pregnancy-related complications on postdonation outcomes. In February 2023, the American Society of Transplantation Women's Health Community of Practice held a virtual Controversies Conference on reproductive health, contraception, and pregnancy after transplantation and living donation. Experts in the field presented the available data. Smaller breakout sessions were created to discuss findings, identify knowledge gaps, and develop recommendations. We present the conference findings related to living donation. The evidence reviewed shows that gestational hypertension and gestational diabetes mellitus before kidney donation have been associated with an increased risk of developing postdonation hypertension and diabetes mellitus, respectively, without increasing the risk of developing an eGFR <45 ml/min after donation. The risk of preeclampsia in living kidney donors increases to 4%-10%, and low-dose aspirin may help reduce that risk. Little is known about the financial burden for living donors who become pregnant, their risk of postpartum depression, or the optimal time between donation and conception. The data on living liver donors are even scarcer. The creation of a registry of donor candidates may help answer many of these questions and, in turn, educate prospective donors so that they can make an informed choice.
{"title":"Living Donation and Pregnancy-Related Complications: State of the Evidence and Call To Action for Improved Risk Assessment.","authors":"Ana P Rossi, Goni Katz-Greenberg, Lisa Coscia, Carla W Brady, Christina Doligalski, Roxanna A Irani, Arthur Matas, Silvi Shah, Krista L Lentine","doi":"10.2215/CJN.0000000593","DOIUrl":"10.2215/CJN.0000000593","url":null,"abstract":"<p><p>Living kidney donation and living liver donation significantly increases organ supply to make lifesaving transplants possible, offering survival benefits to the recipients and cost savings to society. Of all living donors, 40% are women of childbearing age. However, limited data exist regarding the effect of donation on future pregnancies and of pregnancy-related complications on postdonation outcomes. In February 2023, the American Society of Transplantation Women's Health Community of Practice held a virtual Controversies Conference on reproductive health, contraception, and pregnancy after transplantation and living donation. Experts in the field presented the available data. Smaller breakout sessions were created to discuss findings, identify knowledge gaps, and develop recommendations. We present the conference findings related to living donation. The evidence reviewed shows that gestational hypertension and gestational diabetes mellitus before kidney donation have been associated with an increased risk of developing postdonation hypertension and diabetes mellitus, respectively, without increasing the risk of developing an eGFR <45 ml/min after donation. The risk of preeclampsia in living kidney donors increases to 4%-10%, and low-dose aspirin may help reduce that risk. Little is known about the financial burden for living donors who become pregnant, their risk of postpartum depression, or the optimal time between donation and conception. The data on living liver donors are even scarcer. The creation of a registry of donor candidates may help answer many of these questions and, in turn, educate prospective donors so that they can make an informed choice.</p>","PeriodicalId":50681,"journal":{"name":"Clinical Journal of the American Society of Nephrology","volume":"19 12","pages":"1659-1670"},"PeriodicalIF":8.5,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11637692/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142802993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-12-01Epub Date: 2024-10-11DOI: 10.2215/CJN.0000000000000537
Karthik K Tennankore, Keith McCullough, Brian Bieber, Yeoungjee Cho, David W Johnson, Talerngsak Kanjanabuch, Hideki Kawanishi, Yong-Lim Kim, Mark Lambie, Claudio Rigatto, Jenny Shen, Martin Schreiber, Jeffrey Perl, Ronald L Pisoni
{"title":"Prevalence and Outcomes of Chronic Kidney Disease-Associated Pruritus: International Results from Peritoneal Dialysis Outcomes and Practice Patterns Study.","authors":"Karthik K Tennankore, Keith McCullough, Brian Bieber, Yeoungjee Cho, David W Johnson, Talerngsak Kanjanabuch, Hideki Kawanishi, Yong-Lim Kim, Mark Lambie, Claudio Rigatto, Jenny Shen, Martin Schreiber, Jeffrey Perl, Ronald L Pisoni","doi":"10.2215/CJN.0000000000000537","DOIUrl":"10.2215/CJN.0000000000000537","url":null,"abstract":"","PeriodicalId":50681,"journal":{"name":"Clinical Journal of the American Society of Nephrology","volume":"19 12","pages":"1622-1634"},"PeriodicalIF":8.5,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11637705/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142802996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-12-01Epub Date: 2024-11-01DOI: 10.2215/CJN.0000000610
Marcelle Tuttle, Mark J Sarnak
{"title":"Cardiopulmonary Exercise Testing in Patients with Chronic Kidney Disease.","authors":"Marcelle Tuttle, Mark J Sarnak","doi":"10.2215/CJN.0000000610","DOIUrl":"10.2215/CJN.0000000610","url":null,"abstract":"","PeriodicalId":50681,"journal":{"name":"Clinical Journal of the American Society of Nephrology","volume":" ","pages":"1524-1526"},"PeriodicalIF":8.5,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11637704/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142559303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-12-01Epub Date: 2024-11-01DOI: 10.2215/CJN.0000000608
{"title":"Correction: BNT162b2 versus mRNA-1273 Third Dose COVID-19 Vaccine in Patients with CKD and Maintenance Dialysis Patients.","authors":"","doi":"10.2215/CJN.0000000608","DOIUrl":"10.2215/CJN.0000000608","url":null,"abstract":"","PeriodicalId":50681,"journal":{"name":"Clinical Journal of the American Society of Nephrology","volume":" ","pages":"1671-1672"},"PeriodicalIF":8.5,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11637706/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142407171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-12-01Epub Date: 2024-10-21DOI: 10.2215/CJN.0000000000000559
Laura Pyle, Ye Ji Choi, Phoom Narongkiatikhun, Kumar Sharma, Sushrut Waikar, Anita Layton, Kalie L Tommerdahl, Ian de Boer, Timothy Vigers, Robert G Nelson, Jane Lynch, Frank Brosius, Pierre J Saulnier, Jesse A Goodrich, Jeanie B Tryggestad, Elvira Isganaitis, Fida Bacha, Kristen J Nadeau, Daniel van Raalte, Matthias Kretzler, Hiddo Heerspink, Petter Bjornstad
{"title":"Proteomic Analysis Uncovers Multiprotein Signatures Associated with Early Diabetic Kidney Disease in Youth with Type 2 Diabetes Mellitus.","authors":"Laura Pyle, Ye Ji Choi, Phoom Narongkiatikhun, Kumar Sharma, Sushrut Waikar, Anita Layton, Kalie L Tommerdahl, Ian de Boer, Timothy Vigers, Robert G Nelson, Jane Lynch, Frank Brosius, Pierre J Saulnier, Jesse A Goodrich, Jeanie B Tryggestad, Elvira Isganaitis, Fida Bacha, Kristen J Nadeau, Daniel van Raalte, Matthias Kretzler, Hiddo Heerspink, Petter Bjornstad","doi":"10.2215/CJN.0000000000000559","DOIUrl":"10.2215/CJN.0000000000000559","url":null,"abstract":"","PeriodicalId":50681,"journal":{"name":"Clinical Journal of the American Society of Nephrology","volume":" ","pages":"1603-1612"},"PeriodicalIF":8.5,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11637700/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142479854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Standardized Long-Term Care for Living Kidney Donors.","authors":"Kelly L Helm","doi":"10.2215/CJN.0000000614","DOIUrl":"10.2215/CJN.0000000614","url":null,"abstract":"","PeriodicalId":50681,"journal":{"name":"Clinical Journal of the American Society of Nephrology","volume":"19 12","pages":"1513-1514"},"PeriodicalIF":8.5,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11637696/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142803026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-12-01Epub Date: 2024-11-07DOI: 10.2215/CJN.0000000613
Connie M Rhee
{"title":"CJASN: A Prelude to the Future.","authors":"Connie M Rhee","doi":"10.2215/CJN.0000000613","DOIUrl":"10.2215/CJN.0000000613","url":null,"abstract":"","PeriodicalId":50681,"journal":{"name":"Clinical Journal of the American Society of Nephrology","volume":" ","pages":"1515-1517"},"PeriodicalIF":8.5,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11637698/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142605085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Comparison of Obinutuzumab and Rituximab for Treating Primary Membranous Nephropathy.","authors":"Xiaofan Hu, Muyin Zhang, Jing Xu, Chenni Gao, Xialian Yu, Xiao Li, Hong Ren, Weiming Wang, Jingyuan Xie","doi":"10.2215/CJN.0000000000000555","DOIUrl":"10.2215/CJN.0000000000000555","url":null,"abstract":"","PeriodicalId":50681,"journal":{"name":"Clinical Journal of the American Society of Nephrology","volume":" ","pages":"1594-1602"},"PeriodicalIF":8.5,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11637703/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142114426","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-12-01Epub Date: 2024-02-06DOI: 10.2215/CJN.0000000000000410
Allison C Reaves, Daniel E Weiner, Mark J Sarnak
Kidney failure with replacement therapy and cardiovascular disease are frequently comorbid. In patients with kidney failure with replacement therapy, cardiovascular disease is a major contributor to morbidity and mortality. Conventional thrice-weekly in-center dialysis confers risk factors for cardiovascular disease, including acute hemodynamic fluctuations and rapid shifts in volume and solute concentration. Home hemodialysis and peritoneal dialysis (PD) may offer benefits in attenuation of cardiovascular disease risk factors primarily through improved volume and BP control, reduction (or slowing progression) of left ventricular mass, decreased myocardial stunning, and improved bone and mineral metabolism. Importantly, although trial data are available for several of these risk factors for home hemodialysis, evidence for PD is limited. Among patients with prevalent cardiovascular disease, home hemodialysis and PD may also have potential benefits. PD may offer particular advantages in heart failure given it removes volume directly from the splanchnic circulation, thus offering an efficient method of relieving intravascular congestion. PD also avoids the risk of blood stream infections in patients with cardiac devices or venous wires. We recognize that both home hemodialysis and PD are also associated with potential risks, and these are described in more detail. We conclude with a discussion of barriers to home dialysis and the critical importance of interdisciplinary care models as one component of advancing health equity with respect to home dialysis.
肾衰竭替代疗法和心血管疾病经常并发。在接受替代治疗的肾衰竭患者中，心血管疾病是发病率和死亡率的主要因素。传统的每周三次中心内透析是心血管疾病的危险因素，包括急性血液动力学波动以及容量和溶质浓度的快速变化。家庭血液透析（HD）和腹膜透析（PD）主要通过改善容量和血压控制、减少（或减缓）左心室肿块、减少心肌损伤以及改善骨骼和矿物质代谢来减少心血管疾病风险因素。重要的是，虽然针对居家 HD 的其中几个风险因素已有试验数据，但针对腹膜透析的证据却很有限。在心血管疾病流行的患者中，居家 HD 和腹膜透析也可能具有潜在的益处。腹膜透析可直接从脾脏循环中抽出血容量，从而提供一种有效的方法来缓解血管内充血，因此对心力衰竭患者具有特别的优势。腹腔透析还可避免使用心脏设备或静脉导线的患者发生血流感染的风险。我们认识到，家庭 HD 和腹腔透析都存在潜在风险，下文将对此进行详细介绍。最后，我们讨论了家庭透析的障碍以及跨学科护理模式作为促进家庭透析健康公平的一个组成部分的重要性。
{"title":"Home Dialysis in Patients with Cardiovascular Diseases.","authors":"Allison C Reaves, Daniel E Weiner, Mark J Sarnak","doi":"10.2215/CJN.0000000000000410","DOIUrl":"10.2215/CJN.0000000000000410","url":null,"abstract":"<p><p>Kidney failure with replacement therapy and cardiovascular disease are frequently comorbid. In patients with kidney failure with replacement therapy, cardiovascular disease is a major contributor to morbidity and mortality. Conventional thrice-weekly in-center dialysis confers risk factors for cardiovascular disease, including acute hemodynamic fluctuations and rapid shifts in volume and solute concentration. Home hemodialysis and peritoneal dialysis (PD) may offer benefits in attenuation of cardiovascular disease risk factors primarily through improved volume and BP control, reduction (or slowing progression) of left ventricular mass, decreased myocardial stunning, and improved bone and mineral metabolism. Importantly, although trial data are available for several of these risk factors for home hemodialysis, evidence for PD is limited. Among patients with prevalent cardiovascular disease, home hemodialysis and PD may also have potential benefits. PD may offer particular advantages in heart failure given it removes volume directly from the splanchnic circulation, thus offering an efficient method of relieving intravascular congestion. PD also avoids the risk of blood stream infections in patients with cardiac devices or venous wires. We recognize that both home hemodialysis and PD are also associated with potential risks, and these are described in more detail. We conclude with a discussion of barriers to home dialysis and the critical importance of interdisciplinary care models as one component of advancing health equity with respect to home dialysis.</p>","PeriodicalId":50681,"journal":{"name":"Clinical Journal of the American Society of Nephrology","volume":" ","pages":"1646-1655"},"PeriodicalIF":8.5,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11637708/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139405114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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