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Online educational intervention: Improving maternal knowledge and attitudes in providing developmental stimulation for stunting toddlers 在线教育干预:改善母亲在为发育迟缓的幼儿提供发育刺激方面的知识和态度
Pub Date : 2024-02-26 DOI: 10.52225/narra.v4i1.591
Faridah Faridah, A. Anies, M. Kartasurya, B. Widjanarko
Stunting remains a significant public health concern, impacting physical growth and impeding children's development. Mothers, who play a crucial role in stimulating children's development, often encounter barriers in providing effective stimulation, primarily due to limited access to appropriate resources and information. Online education can bridge this gap by offering easily accessible learning. This aim of this study was to determine the effect of online education on maternal knowledge and attitudes in providing developmental stimulation for stunting toddlers. A quasi-experimental research design was employed, comprising a treatment group and a control group, each consisting of 46 mothers with stunting toddlers, sampled purposively. The treatment group received an online developmental stimulation educational intervention through WhatsApp groups for twelve meetings, each lasting 1.5 to 2 hours. Meanwhile, the control group participated in a stunting assistance program provided by the community health centers (Puskesmas). To compare the knowledge and attitudes between groups, Mann-Whitney and independent Student t-test were used. The assessment of intervention effects on knowledge and attitudes was conducted using Wilcoxon and paired Student t-test within each group. Following the educational intervention on developmental stimulation, there was a significant increase in knowledge; however, there was no significant difference in attitudes. The treatment group (mean score 3.9±1.76) had a higher increase in knowledge scores compared to the control group (2.0±2.25) with a p<0.001. Nonetheless, no significant difference in attitudes was observed between the two groups with the mean change scores was 5.8±15.31 in treatment group and 2.5±18.69 for control group, with a p=0.335. This study suggests that providing online education leads to increased knowledge scores but does not impact attitudes significantly. Additional educational approaches should be considered to enhance maternal attitudes.
发育迟缓仍然是一个重大的公共卫生问题,影响着儿童的身体发育并阻碍其发展。母亲在刺激儿童发育方面发挥着至关重要的作用,但她们在提供有效刺激方面常常遇到障碍,主要原因是获得适当资源和信息的途径有限。在线教育可以通过提供便捷的学习方式来弥补这一差距。本研究旨在确定在线教育对母亲为发育迟缓的幼儿提供发育刺激的知识和态度的影响。本研究采用了准实验研究设计,包括治疗组和对照组,每组由 46 位有发育迟缓幼儿的母亲组成,抽样对象均为特定人群。治疗组通过 WhatsApp 群组接受在线发育刺激教育干预,共 12 次会议,每次会议持续 1.5 至 2 小时。同时,对照组参加了由社区卫生中心(Puskesmas)提供的发育迟缓援助项目。为了比较各组之间的知识和态度,采用了曼-惠特尼检验和独立学生 t 检验。在各组内,采用 Wilcoxon 和配对学生 t 检验对知识和态度的干预效果进行评估。在对儿童进行发育刺激教育干预后,儿童的知识水平有了显著提高,但在态度方面没有明显差异。与对照组(2.0±2.25)相比,治疗组(平均分 3.9±1.76)的知识得分增加较多,P<0.001。然而,两组在态度上没有明显差异,治疗组的平均变化分数为 5.8±15.31,对照组为 2.5±18.69,P=0.335。本研究表明,提供在线教育可提高知识得分,但对态度的影响不大。应考虑采用其他教育方法来提高产妇的态度。
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引用次数: 0
Cryptogenic stroke in a 5-year-old girl with patent foramen ovale: A rare case 一名患有卵圆孔未闭的 5 岁女孩隐源性中风:罕见病例
Pub Date : 2024-02-26 DOI: 10.52225/narra.v4i1.273
H. Dimiati, R. Rasaki, Te Haypheng
Stroke ranks among the prevalent factors contributing to child mortality. Cryptogenic stroke has been linked with patent foramen ovale (PFO), which has been suggested as a possible route for thrombus, gas bubble, or another particulate that comes through systemic venous circulation to the brain artery. Yet, the most effective approach for managing cryptogenic stroke involving a PFO remains uncertain. This case aims to report a PFO patient with complications of stroke. A 5-year-old girl was admitted to the emergency department at Dr. Zainoel Abidin Hospital, Banda Aceh, Indonesia, after experiencing numbness and weakness on her right side and a sudden onset of slurred speech three days before admission. Laboratory findings only showed leukocytosis, while coagulation tests were normal. Non-contrast brain CT revealed an occurrence of cerebral infarction in the left hemisphere. Transcranial Doppler showed no atherosclerosis in cerebral arteries, and carotid Doppler ultrasound results were reported normal. Transthoracic echocardiography showed a PFO with the right-to-left shunt. The patient was treated with an intravenous infusion of citicoline 250 mg twice daily, oral aspirin 80 mg daily, and oral mecobalamin 250 mg daily and was planned to undergo a PFO closure procedure. However, the patient’s parents rejected the plan to perform a PFO closure procedure. PFO has the potential to be a contributing factor to cryptogenic stroke among children. PFO closure followed by antiplatelet therapy for a couple of months has been shown to outperform medical therapy alone. However, additional evaluation should be done to cautiously consider the PFO closure procedure in children.
中风是导致儿童死亡的主要因素之一。隐源性卒中与卵圆孔未闭(PFO)有关,有人认为卵圆孔未闭可能是血栓、气泡或其他微粒通过全身静脉循环进入脑动脉的途径。然而,治疗涉及 PFO 的隐源性卒中的最有效方法仍不确定。本病例旨在报告一名并发脑卒中的 PFO 患者。印度尼西亚班达亚齐省扎伊诺尔-阿比丁医生医院急诊科收治了一名5岁女孩,入院前三天她出现右侧肢体麻木和无力,并突然出现言语不清。实验室检查结果仅显示白细胞增多,而凝血测试正常。非对比脑部 CT 显示左半球发生脑梗塞。经颅多普勒显示脑动脉无动脉粥样硬化,颈动脉多普勒超声结果正常。经胸超声心动图显示存在右向左分流的 PFO。患者接受了静脉注射柠檬胆碱 250 毫克,每天两次,口服阿司匹林 80 毫克,每天口服甲钴胺 250 毫克的治疗,并计划接受 PFO 关闭手术。然而,患者的父母拒绝了进行PFO闭合术的计划。PFO 有可能成为儿童隐源性卒中的诱因。事实证明,PFO 关闭术后再进行几个月的抗血小板治疗效果优于单纯的药物治疗。然而,在考虑对儿童进行 PFO 关闭术时,应进行更多的评估以谨慎行事。
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引用次数: 0
Knowledge, attitude, and practices of midwives on premature rupture of membranes (PROM): A cross-sectional study in Samosir and Toba, Indonesia 助产士对胎膜早破(PROM)的认识、态度和做法:印度尼西亚萨莫西尔和多巴的横断面研究
Pub Date : 2024-02-15 DOI: 10.52225/narra.v4i1.335
S. Lumbanraja, Immanuel DL. Tobing, Heru Santosa, Mahyuddin K. M. Nasution, E. Aritonang, Muhammad Ichwan, F. Imelda, Andre MP. Siahaan
Indonesia has a significantly higher maternal mortality ratio (MMR) than other countries in Southeast Asia, and infection is one of the most common causes of maternal deaths, of which premature rupture of membranes (PROM) can be the consequence of the infections. In primary healthcare settings, midwives play an important role in identifying and managing PROM appropriately; however, studies on their knowledge, attitudes, and practices related to PROM are limited. The aim of this study was to determine the midwives' knowledge, attitude and healthcare practice on PROM in Indonesia. A cross-sectional study was conducted among midwives at primary healthcare facilities in Samosir and Toba Regency, North Sumatra, Indonesia, from July to November 2022. The knowledge, attitude and practice towards PROM were assessed. Results showed that 57.5% of midwives had poor knowledge and 35.1% had poor attitude levels. There were 4.9% of midwives referred the patients immediately to the hospital. Our data indicated that aged 31−40 or 41−50 years, having a lower than bachelor degree and having a higher monthly number of referred PROM patients were significantly associated with poor knowledge compared to younger, having a bachelor degree, and lower monthly referral patient number, respectively. Similarly, younger, having higher degree and a having lower monthly referral number of PROM cases were associated with higher chances of having a sufficient-good attitude towards PROM. This study highlights that a significant percentage of midwives had poor levels of knowledge and attitude, and age, educational level and monthly referral number of PROM cases were associated with the level of knowledge and attitude.
印度尼西亚的孕产妇死亡率(MMR)明显高于东南亚其他国家,而感染是孕产妇死亡的最常见原因之一,其中胎膜早破(PROM)可能是感染的后果。在初级医疗保健环境中,助产士在识别和适当管理胎膜早破方面发挥着重要作用;然而,有关助产士对胎膜早破的相关知识、态度和实践的研究却很有限。本研究旨在了解印度尼西亚助产士对 PROM 的认识、态度和医疗实践。这项横断面研究于 2022 年 7 月至 11 月期间在印度尼西亚北苏门答腊省 Samosir 和 Toba 地区的初级医疗保健机构对助产士进行了调查。研究评估了助产士对PROM的认识、态度和实践。结果显示,57.5%的助产士知识水平较低,35.1%的助产士态度较差。有 4.9% 的助产士会立即将患者转至医院。我们的数据显示,年龄在 31-40 岁或 41-50 岁、学历低于学士学位以及每月转诊的 PROM 患者人数较多的助产士分别与知识贫乏、年龄较小、学历为学士学位以及每月转诊患者人数较少明显相关。同样,年龄越小、学历越高、每月转诊的 PROM 患者人数越少,则越有可能对 PROM 持足够好的态度。本研究强调,相当一部分助产士的知识水平和态度不佳,而年龄、教育程度和每月转介的 PROM 个案数与知识水平和态度有关。
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引用次数: 0
Knowledge, attitude, and practices of midwives on premature rupture of membranes (PROM): A cross-sectional study in Samosir and Toba, Indonesia 助产士对胎膜早破(PROM)的认识、态度和做法:印度尼西亚萨莫西尔和多巴的横断面研究
Pub Date : 2024-02-15 DOI: 10.52225/narra.v4i1.335
S. Lumbanraja, Immanuel DL. Tobing, Heru Santosa, Mahyuddin K. M. Nasution, E. Aritonang, Muhammad Ichwan, F. Imelda, Andre MP. Siahaan
Indonesia has a significantly higher maternal mortality ratio (MMR) than other countries in Southeast Asia, and infection is one of the most common causes of maternal deaths, of which premature rupture of membranes (PROM) can be the consequence of the infections. In primary healthcare settings, midwives play an important role in identifying and managing PROM appropriately; however, studies on their knowledge, attitudes, and practices related to PROM are limited. The aim of this study was to determine the midwives' knowledge, attitude and healthcare practice on PROM in Indonesia. A cross-sectional study was conducted among midwives at primary healthcare facilities in Samosir and Toba Regency, North Sumatra, Indonesia, from July to November 2022. The knowledge, attitude and practice towards PROM were assessed. Results showed that 57.5% of midwives had poor knowledge and 35.1% had poor attitude levels. There were 4.9% of midwives referred the patients immediately to the hospital. Our data indicated that aged 31−40 or 41−50 years, having a lower than bachelor degree and having a higher monthly number of referred PROM patients were significantly associated with poor knowledge compared to younger, having a bachelor degree, and lower monthly referral patient number, respectively. Similarly, younger, having higher degree and a having lower monthly referral number of PROM cases were associated with higher chances of having a sufficient-good attitude towards PROM. This study highlights that a significant percentage of midwives had poor levels of knowledge and attitude, and age, educational level and monthly referral number of PROM cases were associated with the level of knowledge and attitude.
印度尼西亚的孕产妇死亡率(MMR)明显高于东南亚其他国家,而感染是孕产妇死亡的最常见原因之一,其中胎膜早破(PROM)可能是感染的后果。在初级医疗保健环境中,助产士在识别和适当管理胎膜早破方面发挥着重要作用;然而,有关助产士对胎膜早破的相关知识、态度和实践的研究却很有限。本研究旨在了解印度尼西亚助产士对 PROM 的认识、态度和医疗实践。这项横断面研究于 2022 年 7 月至 11 月期间在印度尼西亚北苏门答腊省 Samosir 和 Toba 地区的初级医疗保健机构对助产士进行了调查。研究评估了助产士对PROM的认识、态度和实践。结果显示,57.5%的助产士知识水平较低,35.1%的助产士态度较差。有 4.9% 的助产士会立即将患者转至医院。我们的数据显示,年龄在 31-40 岁或 41-50 岁、学历低于学士学位以及每月转诊的 PROM 患者人数较多的助产士分别与知识贫乏、年龄较小、学历为学士学位以及每月转诊患者人数较少明显相关。同样,年龄越小、学历越高、每月转诊的 PROM 患者人数越少,则越有可能对 PROM 持足够好的态度。本研究强调,相当一部分助产士的知识水平和态度不佳,而年龄、教育程度和每月转介的 PROM 个案数与知识水平和态度有关。
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引用次数: 0
Exploring the therapeutic potential of functional foods for diabetes: A bibliometric analysis and scientific mapping 探索功能性食品对糖尿病的治疗潜力:文献计量分析和科学绘图
Pub Date : 2024-01-27 DOI: 10.52225/narra.v4i1.382
N. Wiyono, R. D. Yudhani, Brian Wasita, Suyatmi Suyatmi, Lusi O. Wardhani, R. Pesik, K. Yarsa, R. F. Rahayu
The incidence of diabetes is increasingly becoming a global health burden. Meanwhile, in recent years, functional foods have been intensively investigated for diabetes management. These foods provide health benefits due to their bioactive compounds that enhance the metabolism and lower the risk of chronic diseases, such as diabetes. The aim of this study was to explore the keywords, countries/territories, publication numbers, institutions, authors, and journals associated with functional foods for the management of diabetes using a comprehensive bibliometric analysis method. Scopus database was used to compile the information, followed by VOSviewer for comprehensive bibliometric data analysis. A total of 1,226 Scopus articles that met the inclusion criteria were analyzed. The results showed that the greatest expansion in research occurred in 2012, and China was identified as the most productive nation in this field. In addition, Food and Function was found as the most recognized journal in this area, and Singh, R.B. as well as Zengin, G. made the greatest contribution. The bibliometric data also illustrated several mechanisms of functional foods for diabetes management, including antioxidant activity, effect on the gastrointestinal microbiomes, and inhibitor α-amylase. These results underscore the immense potential of functional foods in the diabetes management and provide guidance for future research on this subject.
糖尿病的发病率正日益成为全球健康的负担。与此同时,近年来,人们对功能性食品在糖尿病管理方面的作用进行了深入研究。这些食品中的生物活性化合物能促进新陈代谢,降低患糖尿病等慢性疾病的风险,从而为健康带来益处。本研究的目的是采用文献计量学综合分析方法,探讨与用于糖尿病管理的功能性食品相关的关键词、国家/地区、出版号、机构、作者和期刊。我们使用 Scopus 数据库汇编信息,然后使用 VOSviewer 进行综合文献计量数据分析。共分析了 1,226 篇符合纳入标准的 Scopus 文章。结果表明,2012 年的研究规模最大,中国被认为是该领域最有成果的国家。此外,《食品与功能》被认为是该领域最受认可的期刊,辛格(Singh, R.B.)和曾金(Zengin, G.)做出了最大贡献。文献计量学数据还说明了功能食品治疗糖尿病的几种机制,包括抗氧化活性、对胃肠道微生物群的影响以及抑制α-淀粉酶。这些结果凸显了功能食品在糖尿病管理方面的巨大潜力,并为今后这方面的研究提供了指导。
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引用次数: 0
Effectiveness of upper arm and breathing exercises to improve inflammatory markers in severe COVID-19 patients 上臂和呼吸运动对改善严重 COVID-19 患者炎症指标的效果
Pub Date : 2024-01-01 DOI: 10.52225/narra.v4i1.417
A. P. Tarigan, Ruby Firdaus, P. Pandia, Andika Pradana, Muntasir Abdullah, S. P. Sinaga, Wahyu Wijanarko, Bibit Triwahyudi, Yeni Vera, Maryaningsih Maryaningsih, Putri C. Eyanoer, Aditya S. Listyoko
Studies have suggested associations between inflammatory markers with the severity of coronavirus disease 2019 (COVID-19). Therefore, exercises that could reduce the level of inflammatory markers might be beneficial. The aim of this study was to determine the effect of upper arms and breathing exercises on inflammatory markers such as ferritin, lactate dehydrogenase (LDH), and C-reactive protein (CRP) in severe COVID-19 patients. A quasi-experimental with pre-test and post-test control group design was conducted among severe COVID-19 aged 18–70 years old, with or without comorbidities. Baseline data of inflammatory markers (ferritin, LDH, and CRP) were measured before the exercises and repeated post-exercise. The upper arm and breathing exercises were performed for ten days, twice a day (morning and evening) for ten minutes. A paired Student t-test was used to assess the changes in the inflammatory markers’ levels. Our data indicated that levels of ferritin and CRP were not significantly different between pre- and post-exercise. However, the level of LDH decreased significantly from 481.35 U/L to 331.80 U/L (p=0.001). This study highlights that pulmonary rehabilitation exercises might be beneficial to enhance the recovery process in severe COVID-19 patients.
研究表明,炎症标志物与冠状病毒疾病 2019(COVID-19)的严重程度有关。因此,能降低炎症标志物水平的运动可能是有益的。本研究旨在确定上臂和呼吸运动对严重COVID-19患者的铁蛋白、乳酸脱氢酶(LDH)和C反应蛋白(CRP)等炎症指标的影响。研究人员在 18-70 岁、有或没有合并症的重度 COVID-19 患者中进行了前测和后测对照组的准实验设计。在运动前测量炎症指标(铁蛋白、低密度脂蛋白胆固醇和 CRP)的基线数据,并在运动后重复测量。上臂和呼吸练习为期十天,每天两次(早晚),每次十分钟。采用配对学生 t 检验来评估炎症标志物水平的变化。我们的数据表明,铁蛋白和 CRP 水平在运动前和运动后没有明显差异。然而,LDH 水平从 481.35 U/L显著下降至 331.80 U/L(P=0.001)。本研究强调,肺康复运动可能有益于促进严重 COVID-19 患者的康复进程。
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引用次数: 0
Physical exercise and chicken egg white supplementation increase muscle mass of stable COPD patients 体育锻炼和补充鸡蛋白可增加慢性阻塞性肺病稳定期患者的肌肉质量
Pub Date : 2024-01-01 DOI: 10.52225/narra.v4i1.406
Mona N. Amin, A. P. Tarigan, Andika Pradana, Taufik Ashar, Osakue E. Osareniro
Patients with chronic obstructive pulmonary disease (COPD) commonly exhibit muscle atrophy and dysfunction due to a reduction in muscle mass; and protein supplements such as chicken egg whites have been reported to improve muscle mass. The aim of this study was to evaluate the impact of physical exercise and egg white supplementation on the muscle mass of COPD patients. An experimental study was conducted among stable COPD patients at Universitas Sumatra Utara Hospital Medan, Indonesia, between August and October 2022. The patients were divided into two groups, control and interventional groups, with each patient subjected to a pre- and post-muscle mass assessment. All the patients performed respiratory endurance and upper extremity muscle strength training three times/week for a total of 12 weeks. In addition, the patients in the intervention group were also given egg white supplementation (10 eggs/day) during the period of intervention in addition to the physical training. The Wilcoxon and Mann-Whitney tests were performed to identify the significance of the difference between pre- and post-intervention and between the control and intervention groups, respectively. A total of 38 COPD patients were included in the study, 19 from each group. Our data suggested no significant difference in muscle mass of the patients in the control group before and after 12 weeks of physical exercise (pre-intervention 27.37±4.54% and post-intervention 27.68±4.5% with p=0.174). However, there was a significant muscle mass increment of patients in the intervention group upon 12 weeks of physical training and egg white supplementation (pre-intervention 27.18±4.15%, post-intervention 29.95±3.76%, p<0.001). A significant difference in muscle mass was observed between patients in the control and the intervention groups (p=0.046) after the intervention. The study highlights that physical exercise in combination with egg white supplementation may serve as potential and effective non-pharmacological treatment for muscle mass restoration in COPD patients as compared to physical exercise alone.
慢性阻塞性肺病(COPD)患者通常会因肌肉质量下降而出现肌肉萎缩和功能障碍;据报道,鸡蛋白等蛋白质补充剂可提高肌肉质量。本研究旨在评估体育锻炼和补充鸡蛋清对慢性阻塞性肺病患者肌肉质量的影响。2022 年 8 月至 10 月期间,印度尼西亚棉兰苏门答腊大学医院对病情稳定的慢性阻塞性肺病患者进行了一项实验研究。患者被分为两组,即对照组和干预组,每名患者都接受了前和后肌肉质量评估。所有患者均进行呼吸耐力和上肢肌力训练,每周三次,共12周。此外,在干预期间,干预组患者除了接受体能训练外,还补充蛋白(每天 10 个鸡蛋)。研究人员分别用 Wilcoxon 检验和 Mann-Whitney 检验来确定干预前与干预后、对照组与干预组之间差异的显著性。研究共纳入了 38 名慢性阻塞性肺病患者,每组 19 人。我们的数据表明,对照组患者的肌肉质量在体育锻炼 12 周前后无明显差异(干预前为 27.37±4.54%,干预后为 27.68±4.5%,P=0.174)。然而,干预组患者在进行为期 12 周的体育锻炼并补充蛋白后,肌肉质量明显增加(干预前 27.18±4.15%,干预后 29.95±3.76%,P<0.001)。干预后,对照组和干预组患者的肌肉质量有明显差异(P=0.046)。该研究强调,与单独进行体育锻炼相比,体育锻炼与补充蛋白相结合可作为恢复慢性阻塞性肺病患者肌肉质量的潜在、有效的非药物疗法。
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引用次数: 0
Psoriasis vulgaris patient with psoriatic arthritis managed with interleukin-17A inhibitor: Balancing benefits and adverse effects 使用白细胞介素-17A抑制剂治疗伴有银屑病关节炎的寻常型银屑病患者:平衡益处与不良反应
Pub Date : 2024-01-01 DOI: 10.52225/narra.v4i1.207
Wina S. Utama, Wahyu Lestari, Sitti Hajar, Mahriani Sylvawani, F. D. Ismida, R. Akele
Psoriasis vulgaris is a significant health problem and up to 30% of the patients are most likely to develop psoriatic arthritis. Secukinumab, an interleukin-17A (IL-17A) inhibitor, is used to treat patients with moderate-to-severe plaques associated with psoriatic arthritis. The aim of this case report was to highlight the efficacy of secukinumab treatment in a patient with both psoriasis vulgaris and psoriatic arthritis focusing the how to balance the benefits and adverse effects. A 36-year-old female came to Dr. Zainoel Abidin Hospital, Banda Aceh, Indonesia with chief complaint of itchy and scaly red plaques almost all over the body. The patient also experienced pain in both knees, both ankle joints and index finger as well as thumb in the right hand in the last year. The patient was diagnosed with psoriasis vulgaris and psoriatic arthritis, then treated with phototherapy and 15 mg of oral methotrexate each week for four weeks. Due to no improvement of the initial treatment, the patient received emollient and secukinumab at a dose of 300 mg/week subcutaneously for five weeks. The lesions began to disappear and the joint pain began to relieve. Secukinumab therapy was continued with a dose of 300 mg/month for six months. However, after six months, the patient complained of acnes appeared on the face. Therefore, the maintenance dose of secukinumab was decreased to 150 mg/month. After the reduced maintenance therapy was given, the patient came back with no complained of acnes. The erythematous plaques on trunk, back, arms and legs have subsided, as well as the joint pain. This case highlights that in a moderate-to-severe psoriasis associated with psoriatic arthritis, secukinumab is highly effective. However, since the potential adverse effects, education and regular follow-up are needed to analyze the success of the treatment and to be able to manage the adverse effects.
寻常型银屑病是一个严重的健康问题,多达 30% 的患者最有可能患上银屑病关节炎。赛库单抗是一种白细胞介素-17A(IL-17A)抑制剂,用于治疗与银屑病关节炎相关的中重度斑块患者。本病例报告旨在强调 secukinumab 对同时患有寻常型银屑病和银屑病关节炎的患者的疗效,重点是如何平衡益处和不良反应。印度尼西亚班达亚齐的扎伊努埃尔-阿比丁医生医院收治了一名36岁的女性患者,主诉全身几乎都有瘙痒和鳞状红色斑块。去年,患者的双膝、双踝关节、右手食指和拇指也出现疼痛。患者被诊断为寻常型银屑病和银屑病关节炎,随后接受了光疗和每周口服 15 毫克甲氨蝶呤的治疗,连续四周。由于最初的治疗效果不佳,患者接受了润肤剂和每周 300 毫克剂量的 secukinumab 皮下注射,持续了五周。皮损开始消失,关节疼痛也开始缓解。塞库单抗以每月 300 毫克的剂量持续治疗了 6 个月。然而,六个月后,患者抱怨脸上出现了痤疮。因此,塞库单抗的维持剂量降至每月 150 毫克。在减少维持治疗剂量后,患者复诊时没有再出现痤疮。躯干、背部、手臂和腿部的红斑以及关节疼痛均已消退。本病例表明,对于伴有银屑病关节炎的中重度银屑病,secukinumab 具有很好的疗效。然而,由于存在潜在的不良反应,因此需要通过教育和定期随访来分析治疗的成功与否,并能够控制不良反应。
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引用次数: 0
Factors influencing histoplasmosis incidence in multidrug-resistant pulmonary tuberculosis patients: A cross-sectional study in Indonesia 影响耐多药肺结核患者组织胞浆菌病发病率的因素:印度尼西亚横断面研究
Pub Date : 2023-12-31 DOI: 10.52225/narra.v3i3.403
Selfi Khairunnisa, N.N. Soeroso, Muntasir Abdullah, Lambok Siahaan, Putri C. Eyanoer, E. R. Daulay, Retno Wahyuningsih, David W Denning
Histoplasmosis is an infectious disease caused by the dimorphic fungus Histoplasma capsulatum, which, in chronic conditions, is generally difficult to distinguish from pulmonary tuberculosis based on its clinical appearance; therefore, diagnostic errors can occur. Meanwhile, the prevalence of multidrug-resistant pulmonary tuberculosis (MDR-TB) in Indonesia remains high. Study determining the incidence of histoplasmosis in MDR-TB is unavailable worldwide. The aim of this study was to determine the risk factors of histoplasmosis incidence in MDR-TB patients in Indonesia. A cross-sectional was conducted at H. Adam Malik General Hospital, Medan, Indonesia and the ELISA platform (semi-quantitative) was used to detect histoplasma antibodies. Factors associated with histoplasmosis incidence among MDR-TB were determined using a Chi-squared test. A total of 50 MDR-TB patients were included this study of which 14 of them (28%) had histoplasmosis. The majority of histoplasmosis occurred in males, in MDR-TB patients with a history of TB treatment and among who had chest x-rays with far-advanced lesions. However, statistical analyses indicated none of those factors (sex, TB treatment history, status of the lung) as well as age group, acid-fast bacillus result, Mycobacterium tuberculosis culture result, having pet, living in damp house, working in the field or plantation, having HIV infection and smoking status were associated with histoplasmosis incidence. This study highlights that the incidence of histoplasmosis is relatively high and therefore further studies are important to be conducted in Indonesia that has a high MDR-TB cases.
组织胞浆菌病是由二形真菌荚膜组织胞浆菌(Histoplasma capsulatum)引起的一种传染病,在慢性病患者中,根据其临床表现一般很难与肺结核区分开来,因此会出现诊断错误。同时,耐多药肺结核(MDR-TB)在印度尼西亚的发病率仍然很高。世界范围内还没有关于组织胞浆菌病在耐多药肺结核中发病率的研究。本研究旨在确定印度尼西亚 MDR-TB 患者中组织胞浆菌病发病率的风险因素。研究在印度尼西亚棉兰的 H. Adam Malik 综合医院进行,采用 ELISA 平台(半定量)检测组织胞浆菌抗体。使用Chi-squared检验确定了与MDR-TB中组织胞浆菌病发病率相关的因素。本研究共纳入 50 名 MDR-TB 患者,其中 14 人(28%)患有组织胞浆菌病。大多数组织胞浆菌病发生在男性、有结核病治疗史的 MDR-TB 患者和胸部 X 光片显示病变较深的患者身上。然而,统计分析表明,这些因素(性别、结核病治疗史、肺部状况)以及年龄组、酸性无菌杆菌结果、结核分枝杆菌培养结果、饲养宠物、居住在潮湿的房屋中、在田间或种植园工作、感染艾滋病毒和吸烟状况均与组织胞浆菌病的发病率无关。这项研究表明,组织胞浆菌病的发病率相对较高,因此在耐多药结核病例较多的印度尼西亚开展进一步研究非常重要。
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引用次数: 0
Characteristics and susceptibility pattern of catheter-associated urinary tract infections (CAUTI) bacteria in Indonesia: A study in a national reference hospital of Sumatra region 2020–2021 印度尼西亚导尿管相关尿路感染 (CAUTI) 细菌的特征和易感性模式:苏门答腊地区一家国家参考医院的研究 2020-2021 年
Pub Date : 2023-12-29 DOI: 10.52225/narra.v3i3.436
Muhammad A. Perdana, Dian D. Wahyuni, Rina Yunita
Catheter-associated urinary tract infection (CAUTI) is defined as a urinary tract infection associated with catheter placement for more than two consecutive days. Hence, antibiotic resistance in the context of CAUTIs represents a substantial challenge. The aim of this study was to present the characteristics of patients with CAUTI and the susceptibility pattern of CAUTI bacteria in the national reference hospital of the Sumatra region of Indonesia. A cross-sectional study was conducted at H. Adam Malik General Hospital, Medan, Indonesia, from 2020 to 2021, using a total sampling. All CAUTI patients included were on catheterization and diagnosed based on the Centers for Disease Control and Prevention (CDC) guidelines. The patient’s urine culture and antibiotic susceptibility test were carried out on the patient’s admitted urine sample for further assessment. Identification of bacteria, antibiotic susceptibility test, and the extended-spectrum beta-lactamase (ESBL) test for Escherichia coli and Klebsiella pneumoniae were conducted using the VITEK-2 Compact. A total of 74 CAUTI patients were included in the study, 59.5% were female, 54.1% were 46–65 years old, and a third had cardiovascular disease comorbidities (33.8%). A total of 83 CAUTI-associated bacteria were isolated. The majority were Gram-negative bacteria (74.7%), and the most bacteria isolated was E. coli (31.3%), followed by K. pneumoniae, Enterococcus faecalis, Acinetobacter baumannii, and Enterococcus faecium. The ESBL test was positive mostly in K. pneumoniae (100%) and E. coli (76.9%). CAUTI-associated E. coli was susceptible to tigecycline, meropenem, ertapenem, nitrofurantoin, and gentamicin. The isolated K. pneumoniae was susceptible to tigecycline, meropenem, ertapenem, and amikacin. While E. faecalis showed susceptibility to tigecycline, nitrofurantoin, vancomycin, imipenem, linezolid, ampicillin, piperacillin/tazobactam, amoxicillin/clavulanic acid, ampicillin/sulbactam, and piperacillin.
导尿管相关性尿路感染(CAUTI)是指连续两天以上放置导尿管引起的尿路感染。因此,CAUTIs 的抗生素耐药性是一个巨大的挑战。本研究旨在介绍印度尼西亚苏门答腊地区国家参考医院中 CAUTI 患者的特征和 CAUTI 细菌的药敏模式。这项横断面研究于 2020 年至 2021 年在印度尼西亚棉兰的 H. Adam Malik 综合医院进行,采用的是总体抽样法。所有CAUTI患者均接受导尿治疗,并根据美国疾病控制和预防中心(CDC)的指南进行诊断。对患者的尿液样本进行尿液培养和抗生素药敏试验,以便进一步评估。使用 VITEK-2 Compact 对大肠埃希菌和肺炎克雷伯菌进行细菌鉴定、抗生素药敏试验和扩谱β-内酰胺酶(ESBL)试验。研究共纳入了 74 名 CAUTI 患者,其中 59.5% 为女性,54.1% 年龄在 46-65 岁之间,三分之一的患者合并有心血管疾病(33.8%)。共分离出 83 种 CAUTI 相关细菌。大多数是革兰氏阴性菌(74.7%),分离出最多的细菌是大肠杆菌(31.3%),其次是肺炎双球菌、粪肠球菌、鲍曼不动杆菌和粪肠球菌。ESBL检测结果呈阳性的主要是肺炎双球菌(100%)和大肠杆菌(76.9%)。CAUTI 相关大肠杆菌对替加环素、美罗培南、厄他培南、硝基呋喃妥因和庆大霉素敏感。分离出的肺炎双球菌对替加环素、美罗培南、厄他培南和阿米卡星均敏感。而粪肠球菌则对替加环素、硝基呋喃妥因、万古霉素、亚胺培南、利奈唑胺、氨苄西林、哌拉西林/他唑巴坦、阿莫西林/克拉维酸、氨苄西林/舒巴坦和哌拉西林敏感。
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引用次数: 0
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