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Feasibility of a mindfulness app in parents of a child with medical complexity: A pilot study 正念应用程序在有复杂病症儿童的家长中的可行性:试点研究
IF 2.2 4区 医学 Q1 NURSING Pub Date : 2024-02-19 DOI: 10.1016/j.apnr.2024.151767
Cara Gallegos PhD, RN, EBP-C, Ryoko Kausler PhD, MN, RN, Natalie Cacchillo

The prevalence of pediatric chronic conditions is increasing rapidly. Parents of a child with medical complexity (CMC) experience stress, depression which may also impact family functioning. Research has shown that mindfulness applications (apps) have significantly improved stress and depression in other populations, but have not been studied in this population. The purpose of this pilot study was to assess the feasibility and efficacy of a mindfulness app in parents of a CMC. Parents were recruited to participate from a non-profit organization and asked to use a mindfulness app for 4 weeks and fill out questionnaires before and after the intervention. Eight mothers participated in the study for the entire study period. Data analysis showed that using a mindfulness app in this population is feasible and reduces depressive symptoms and improves family functioning.

儿科慢性病的发病率正在迅速上升。有复杂病症(CMC)儿童的父母会感到压力和抑郁,这也会影响家庭功能。研究表明,正念应用程序(Apps)能显著改善其他人群的压力和抑郁状况,但尚未对这一人群进行研究。这项试点研究的目的是评估正念应用程序在儿童疾病防治中心家长中的可行性和有效性。研究人员从一家非营利组织招募家长参与研究,要求他们使用正念应用程序 4 周,并在干预前后填写调查问卷。八位母亲在整个研究期间参与了研究。数据分析显示,在这一人群中使用正念应用程序是可行的,它可以减少抑郁症状,改善家庭功能。
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引用次数: 0
Assessing the readiness to transition to adult care, perceived medication barriers, and glycemic control among teens with type 1 diabetes 评估 1 型糖尿病青少年患者向成人护理过渡的准备情况、感知到的用药障碍以及血糖控制情况
IF 2.2 4区 医学 Q1 NURSING Pub Date : 2024-02-01 DOI: 10.1016/j.apnr.2024.151772
Arwa Alhamed PhD, RN, CPNP

Aim

This study assessed the readiness to transition (RT) from pediatric to adult care, perceived medication barriers (PMB), and glycemic control in teens with type one diabetes (T1D).

Background

During the transition from pediatric to adult care, teens with T1D are at risk of long-term complications related to impaired adherence. With the increasing prevalence of T1D in Saudi Arabia, research is required to identify the challenges facing teens with T1D during their transition.

Methods

This was a cross-sectional study with a convenient sample of 83 adolescents (12–17 years old) diagnosed with T1D for ≥6 months, their parents, and their pediatric endocrinologists from the pediatric endocrinology clinic in a tertiary hospital in Riyadh. The RT Questionnaire was used to measure RT, and the Medication Barriers Scale was used to measure PMB. Glycemic control was measured using hemoglobin A1c (HbA1c).

Results

About 96 % of teens had HbA1c > 7 %. Male teens had higher HbA1c than female teens. Teens and their parents reported high PMB and low RT. PMB (teens), disease duration, family history of diabetes mellitus, and comorbidity were significant predictors of RT (parents). PMB (teens), teens' age, and having a family history of diabetes mellitus were significant predictors of RT (providers). RT (parents) and RT (providers) were the only significant predictors of HbA1c, with RT (providers) being the strongest predictors of HbA1c.

Conclusions

Health policy reform is required to develop national RT programs to prepare teens with T1D to take full responsibility for managing their medical conditions while ensuring adherence.

目的本研究评估了患有一型糖尿病(T1D)的青少年从儿科治疗向成人治疗过渡(RT)的准备情况、感知到的用药障碍(PMB)以及血糖控制情况。背景在从儿科治疗向成人治疗过渡期间,患有 T1D 的青少年面临着与依从性受损有关的长期并发症风险。方法这是一项横断面研究,研究对象是利雅得一家三甲医院儿科内分泌诊所的 83 名确诊 T1D≥6 个月的青少年(12-17 岁)、他们的父母和儿科内分泌专家。RT 问卷用于测量 RT,用药障碍量表用于测量 PMB。结果 约 96% 的青少年的 HbA1c 为 7%。男性青少年的 HbA1c 高于女性青少年。青少年及其父母报告的 PMB 较高,RT 较低。PMB(青少年)、病程、糖尿病家族史和合并症是预测 RT(家长)的重要因素。PMB(青少年)、青少年年龄和有糖尿病家族史是预测 RT(提供者)的重要因素。结论 需要进行医疗政策改革,以制定全国性的 RT 计划,帮助患有 T1D 的青少年做好准备,在确保坚持治疗的同时,承担起管理自身病情的全部责任。
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引用次数: 0
Association between social capital and quality of life in older adults with subjective cognitive decline: A cross-sectional study 主观认知能力下降的老年人的社会资本与生活质量之间的关系:横断面研究
IF 2.2 4区 医学 Q1 NURSING Pub Date : 2024-02-01 DOI: 10.1016/j.apnr.2024.151773
Yiping Chen , Wei Li , Xin Zhang , Hui Cheng , Yuling Tian , Hui Yang

Background

Subjective cognitive decline (SCD) is increasingly recognized as a clinical and medical risk factor for mild cognitive impairment (MCI) and dementia. Currently, there is little evidence regarding the quality of life (QoL) in older adults with SCD and the impact of social capital on their QoL.

Aims

To examine the perceptions of social capital and QoL among older adults with SCD.

Methods

A total of 325 participants (92.9 % response rate) with a self-reported diagnosis of SCD completed the Chinese version of the 36-item Short-Form Health Survey, the Chinese Shortened Social Capital Scale and the Generalized Anxiety Disorder Scale. A t-test was used to compare the QoL score of our sample with the Chinese norm. Pearson correlation analysis and multivariate linear regression analysis were used to assess the association of social capital with QoL.

Results

Social capital were strongly correlated with the total QoL, as well as its physical component summary and mental component summary. The QoL score of older adults with SCD was significantly lower than the Chinese norm (P  <  0.001). Multivariate analysis showed that social capital, physical activity, nutrition and anxiety symptoms were factors associated with QoL among older SCD population (P  <  0.05).

Conclusion

The findings of the current study suggest that older adults with SCD may experience lower QoL. Social capital is associated with the QoL in older adults with SCD. These findings have implications for clinicians who work with older adults with SCD.

背景主观认知能力下降(SCD)越来越被认为是轻度认知障碍(MCI)和痴呆症的临床和医学风险因素。方法 共有 325 名自我报告诊断为 SCD 的参与者(应答率为 92.9%)完成了中文版 36 项简式健康调查、中文简式社会资本量表和广泛性焦虑症量表。我们用 t 检验比较了样本的 QoL 得分和中国常模。结果社会资本与QoL总分、身体部分总分和精神部分总分都有很强的相关性。患有 SCD 的老年人的 QoL 得分明显低于中国常模(P < 0.001)。多变量分析表明,社会资本、体力活动、营养和焦虑症状是 SCD 老年人群 QoL 的相关因素(P < 0.05)。社会资本与患有 SCD 的老年人的 QoL 有关。这些研究结果对从事 SCD 老年患者工作的临床医生具有启示意义。
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引用次数: 0
Looking back to move forward: Creating a blueprint for success for nurse scientists in the Veterans Health Administration 回顾过去,展望未来:为退伍军人健康管理局的护士科学家绘制成功蓝图
IF 2.2 4区 医学 Q1 NURSING Pub Date : 2024-02-01 DOI: 10.1016/j.apnr.2024.151764
Ashley C. Mog , Cathy M. St. Pierre , Helene J. Moriarty , Sheila Cox Sullivan , Catherine Battaglia

Aim

The purpose of this manuscript is to report the findings of a qualitative content analysis of interviews with VA Nurse Scientists about work life experiences, barriers, and facilitators across the enterprise.

Background

The VA enterprise is widely variable in terms of size, services, research activity, and budget. For this reason, the roles of nurses with a research-focused doctorate are also quite diverse.

Methods

We purposively sampled 18 PhD prepared Nurse Scientists based on a variety geographic locations, titles, and years in the field and who conduct research. We conducted semi-structured interviews over the virtual platform, WebEx. Interviews, averaging 1 h in length, were conducted between April and May 2021. We analyzed interviews using deductive and inductive content analysis.

Results

We found five key factors affecting VA Nurse Scientists. Each factor emerged as an important issue influencing whether Nurse Scientists reported being successful, supported, and productive in their research. These include having: 1) mentorship, 2) supportive leadership 3) available resources, 4) respect and understanding from clinical and research colleagues who understand a Nurse Scientist's role in research, and 5) a career pathway.

Conclusions

VA Nurse Scientists are leaders and innovators who generate evidence to improve health outcomes and promote equity in health and health care of Veterans, their families, and caregivers. Results from this project suggest that many Nurse Scientists need additional mentorship, resources, and networks to advance their development, increase their funding success, and maximize the impact of their role, ultimately enhancing care of Veterans and their families.

背景退伍军人事务部的企业在规模、服务、研究活动和预算方面千差万别。因此,拥有以研究为重点的博士学位的护士的角色也是多种多样的。方法我们根据不同的地理位置、职称和从业年限,有目的地抽取了 18 名准备攻读博士学位并从事研究工作的护士科学家。我们通过 WebEx 虚拟平台进行了半结构化访谈。访谈在 2021 年 4 月至 5 月期间进行,平均时长为 1 小时。我们使用演绎和归纳内容分析法对访谈进行了分析。结果我们发现了影响退伍军人事务部护士科学家的五个关键因素。每个因素都是影响科学家护士是否在研究中取得成功、得到支持和富有成效的重要问题。这些因素包括结论 退伍军人事务部护士科学家是领导者和创新者,他们创造证据来改善退伍军人、其家人和护理人员的健康状况并促进其健康和医疗保健的公平性。本项目的结果表明,许多护士科学家需要更多的指导、资源和网络来促进他们的发展,提高他们的筹资成功率,并最大限度地发挥他们的作用,最终加强对退伍军人及其家人的护理。
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引用次数: 0
The mediation effect of health literacy on social support and health lifestyle of patients with chronic diseases 健康素养对慢性病患者社会支持和健康生活方式的中介效应
IF 2.2 4区 医学 Q1 NURSING Pub Date : 2024-02-01 DOI: 10.1016/j.apnr.2024.151763
Xuemin Zhang , Cuiyun Li , Min Liu , Junfang Sun , Heng Yue , Hugejiletu Bao

Background

Previous studies have identified the antecedents of the lifestyle of many patients with chronic diseases. However, the mechanism of social support affecting the lifestyle of patients with chronic diseases is unclear, and the role of health literacy in social support affecting the lifestyle of patients with chronic diseases has not been found. Therefore, this study aims to explore the status quo of social support, health literacy and healthy lifestyle of patients with chronic diseases in China and the relationship among them.

Methods

Through convenient sampling, 356 patients with chronic diseases were surveyed using a health promoting lifestyle scale, a chronic disease patients' health literacy scale and a social support scale.

Results

There was a pairwise positive correlation between social support, health lifestyle and health literacy (R = 0.397,0.356,0.556, P < 0.01). After controlling gender, age and education level, it is found that social support has a positive impact on health lifestyle, and health literacy plays an intermediary role between social support and health lifestyle, accounting for 45.78 % of the total effect.

Conclusion

To promote the healthy lifestyle of patients with chronic diseases and delay the development of the disease, we should strengthen social support for patients with chronic diseases; We should simultaneously take various measures to improve their health literacy.

背景以往的研究发现了许多慢性病患者生活方式的前因。然而,社会支持影响慢性病患者生活方式的机制尚不明确,健康素养在社会支持影响慢性病患者生活方式中的作用也尚未发现。方法通过方便抽样,采用健康促进生活方式量表、慢性病患者健康素养量表和社会支持量表对 356 名慢性病患者进行调查。结果社会支持、健康生活方式和健康素养之间存在成对正相关(R=0.397,0.356,0.556, P <0.01)。结论为促进慢性病患者的健康生活方式,延缓疾病的发展,应加强对慢性病患者的社会支持;同时应采取各种措施提高慢性病患者的健康素养。
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引用次数: 0
Nurses' moral courage and related factors: A systematic review 护士的道德勇气及相关因素:系统回顾
IF 2.2 4区 医学 Q1 NURSING Pub Date : 2024-02-01 DOI: 10.1016/j.apnr.2024.151768
Reza Abdollahi , Mohammadrasool Ghasemianrad , Amin Hosseinian-Far , Shabnam Rasoulpoor , Nader Salari , Masoud Mohammadi

Background

Nurses face various ethical conflicts when taking care of patients, and such conflicts require moral courage. This systematic review was conducted with the aim of investigating moral courage and its related factors among nurses.

Methods

To find related studies, the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines were followed. The PubMed, Web of Science, Google Scholar, Scopus, Embase and Science Direct databases were searched using keywords such as Courage, Moral Courage, and Nurses, and no lower time limit was imposed when conducting the searches. The identified studies were published between January 2000 and March 2023. Quality of articles was assessed using the STROBE checklist.

Results

The pooled sample size for the 19 included studies was 7863. All studies were observational and cross-sectional. The results showed that three categories of factors most related to moral courage are individual, moral, and factors related to the organization. Underlying factors of each category are also provided within this paper.

Conclusion

Moral courage is an integral part of nursing, which as a profession, is becoming even more challenging with the advancement of science and technology. Therefore, there is a need for nurses and especially nursing managers to be considerate of factors affecting moral courage of nurses, with a view to strengthening the positive factors and reducing the negative impacts.

背景护士在照顾病人时会面临各种伦理冲突,而这种冲突需要道德勇气。本系统综述旨在调查护士的道德勇气及其相关因素。方法为了寻找相关研究,我们遵循了系统综述和荟萃分析首选报告项目(PRISMA)指南。使用勇气、道德勇气和护士等关键词在 PubMed、Web of Science、Google Scholar、Scopus、Embase 和 Science Direct 数据库中进行检索,检索时间不设下限。确定的研究发表于 2000 年 1 月至 2023 年 3 月之间。文章质量采用 STROBE 检查表进行评估。所有研究均为观察性横断面研究。结果显示,与道德勇气最相关的三类因素分别是个人因素、道德因素和组织相关因素。结论道德勇气是护理工作不可或缺的一部分,随着科学技术的发展,护理作为一种职业正变得更具挑战性。因此,护士尤其是护理管理者有必要考虑影响护士道德勇气的因素,以加强积极因素,减少消极影响。
{"title":"Nurses' moral courage and related factors: A systematic review","authors":"Reza Abdollahi ,&nbsp;Mohammadrasool Ghasemianrad ,&nbsp;Amin Hosseinian-Far ,&nbsp;Shabnam Rasoulpoor ,&nbsp;Nader Salari ,&nbsp;Masoud Mohammadi","doi":"10.1016/j.apnr.2024.151768","DOIUrl":"https://doi.org/10.1016/j.apnr.2024.151768","url":null,"abstract":"<div><h3>Background</h3><p>Nurses face various ethical conflicts when taking care of patients, and such conflicts require moral courage. This systematic review was conducted with the aim of investigating moral courage and its related factors among nurses.</p></div><div><h3>Methods</h3><p>To find related studies, the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines were followed. The PubMed, Web of Science, Google Scholar, Scopus, Embase and Science Direct databases were searched using keywords such as Courage, Moral Courage, and Nurses, and no lower time limit was imposed when conducting the searches. The identified studies were published between January 2000 and March 2023. Quality of articles was assessed using the STROBE checklist.</p></div><div><h3>Results</h3><p>The pooled sample size for the 19 included studies was 7863. All studies were observational and cross-sectional. The results showed that three categories of factors most related to moral courage are individual, moral, and factors related to the organization. Underlying factors of each category are also provided within this paper.</p></div><div><h3>Conclusion</h3><p>Moral courage is an integral part of nursing, which as a profession, is becoming even more challenging with the advancement of science and technology. Therefore, there is a need for nurses and especially nursing managers to be considerate of factors affecting moral courage of nurses, with a view to strengthening the positive factors and reducing the negative impacts.</p></div>","PeriodicalId":50740,"journal":{"name":"Applied Nursing Research","volume":"75 ","pages":"Article 151768"},"PeriodicalIF":2.2,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139915098","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The role of organizational culture and communication skills in predicting the quality of nursing care 组织文化和沟通技巧在预测护理质量中的作用
IF 2.2 4区 医学 Q1 NURSING Pub Date : 2024-02-01 DOI: 10.1016/j.apnr.2024.151769
Wafa'a F. Ta'an PhD., RN , Fadi Allama MSN, RN , Brett Williams PhD., FACP

Aims

This study aims to identify the level of nursing care quality and examine its predictors considering nurses' demographic data, organizational culture, and communication skills.

Background

Quality of care is a determinant of the sustainability of any healthcare organization. Therefore, it is imperative to understand how factors may contribute to the quality of nursing care. Limited research is available on the interaction between the concepts of quality of nursing care, communication skills, and organizational culture.

Methods

A cross-sectional multi-site correlational design was used in this study. A convenience sample of 200 nurses from four Jordanian hospitals was recruited. Data was collected using self-reported questionnaires. Descriptive statistics, Pearson correlations, and multiple regression were performed to achieve the study's aims.

Results

The majority of the nurses in this study were females with bachelor's degrees. Age ranged between 22 and 53 years whereas experience ranged from 1 to 30 years. Communication skills significantly predicted the quality of nursing care; however, organizational culture was not a significant predictor of the quality of nursing care. Nevertheless, Pearson r correlation results revealed a significant correlation between organizational culture and communication skills (r = 0.57, p < 0.05).

Conclusion

Nurses and organizational managers can increase the level of quality of nursing care by investing in programs that target improving nurses' communication skills. Providing a good environment in the hospital can increase communication skills between staff members, ultimately increasing the quality of nursing care. Further studies are recommended to elaborate and further uncover concerns related to the current research.

背景护理质量是任何医疗机构可持续发展的决定性因素。因此,当务之急是了解各种因素是如何影响护理质量的。关于护理质量、沟通技巧和组织文化这三个概念之间相互作用的研究十分有限。本研究采用横断面多站点相关性设计,从约旦四家医院的 200 名护士中方便地抽取样本。数据通过自我报告问卷收集。为达到研究目的,进行了描述性统计、皮尔逊相关分析和多元回归分析。年龄在 22 至 53 岁之间,工作经验在 1 至 30 年之间。沟通技巧对护理质量有明显的预测作用,但组织文化对护理质量的预测作用不明显。尽管如此,Pearson r 相关性结果显示,组织文化与沟通技能之间存在显著相关性(r = 0.57,p < 0.05)。医院提供良好的环境可以提高员工之间的沟通技巧,最终提高护理质量。建议进一步开展研究,以阐述和进一步揭示与当前研究相关的问题。
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引用次数: 0
Barriers to initiate a discussion about advance care planning among older Taiwanese residents of nursing homes and their families: A qualitative study 台湾老年疗养院居民及其家人在开始讨论预先护理计划时遇到的障碍:定性研究
IF 2.2 4区 医学 Q1 NURSING Pub Date : 2024-02-01 DOI: 10.1016/j.apnr.2024.151766
Hsin-Tzu Sophie Lee PhD , Chia-Ling Yang PhD , Sei-Ven Leu PhD , Wen-Yu Hu PhD

Background

In Taiwan, the Patients' Right to Autonomy Act was enacted in 2019. However, advance care planning (ACP) implementation rates remain low in long-term care facilities. Aim: This study explored the barriers to initiate a discussion about ACP among older Taiwanese residents of nursing homes and their families.

Methods

A descriptive qualitative design was used. Face-to-face interviews were individually conducted with 38 participants (residents: 18; family members: 20), and data were analyzed through content analysis.

Results

Five themes were identified: (1) having cultural or spiritual concerns (both groups), (2) prioritizing the bigger picture (family) (both groups), (3) waiting for the right time (both groups), (4) feeling unsure (residents), and (5) following the pace of the residents (family members).

Conclusion

The results indicate that discussing ACP with Chinese people and their families clashes with traditional Chinese culture. To implement ACP in long-term care facilities based in regions with ethnically Chinese populations, medical professionals must ensure that the residents and their family members understand advance directives and their role in ensuring a good death and must act as a bridge between residents and their family members to assist them in making consensual end-of-life-care decisions with residents.

背景台湾于2019年颁布了《病人自主权法》。然而,在长期护理机构中,预先护理计划(ACP)的实施率仍然很低。目的:本研究探讨了台湾老年疗养院住户及其家属在启动关于 ACP 的讨论时遇到的障碍。方法:本研究采用了描述性定性设计。对 38 名参与者(住院者:18 人;家庭成员:20 人)进行了面对面访谈,并通过内容分析对数据进行了分析:(结果确定了五个主题:(1)有文化或精神方面的顾虑(两组均有);(2)以大局为重(家属)(两组均有);(3)等待合适的时机(两组均有);(4)感觉不确定(住院患者);(5)跟随住院患者的步伐(家属)。要在华人聚居地区的长期护理机构中实施 ACP,医务人员必须确保住院者及其家属了解预先医疗指示及其在确保良好死亡中的作用,并且必须成为住院者及其家属之间的桥梁,协助他们与住院者一起做出双方同意的临终关怀决定。
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引用次数: 0
Dehumanization in intensive care units and standard wards: A survey for a comparative cross-sectional study 重症监护室和标准病房中的非人化现象:横断面对比研究调查
IF 2.2 4区 医学 Q1 NURSING Pub Date : 2024-02-01 DOI: 10.1016/j.apnr.2024.151774
Cappellini Iacopo, Nuti Chiara, Di Stefano Matteo, Zamidei Lucia, Campiglia Laura, Consales Guglielmo

Objectives

Dehumanization refers to the practice of treating patients as objects rather than individuals with dignity and respect.

Methods

This study explores dehumanization in healthcare, specifically mechanistic dehumanization and self-dehumanization, which can result in poor care and negative outcomes. A cross-sectional observational study was conducted using a dehumanization questionnaire given to 324 nurses in various departments. The study took place at ANONYMIZED, from September to November 2022. The questionnaire analyzed emotions like anger, impatience, and apathy, identified as key dehumanizing factors.

Results

Results indicated that these emotions were prevalent in nurses' perceptions of patients. Interestingly, while Intensive Care nurses often involved families in patient care, leading to higher satisfaction, ward department nurses sometimes viewed patient or family relationships as obstacles. Despite this, 66 % of nurses reported satisfaction with the care provided, while 12 % were indifferent.

Conclusions

The study concludes that the root of dehumanization lies in nurses' inability to feel emotions, the impersonality of care, and the sterility of assistance, leading to self-dehumanization. To combat this, the study suggests strengthening nursing autonomy and education and fostering a positive work environment. The way nurses perceive themselves directly impacts their treatment of patients.

方法 本研究探讨了医疗保健中的非人性化问题,特别是机械性非人性化和自我非人性化,它们可能会导致护理质量低下和不良后果。本研究采用非人性化调查问卷的形式,对不同科室的 324 名护士进行了横断面观察研究。研究于 2022 年 9 月至 11 月在 ANONYMIZED 进行。问卷分析了愤怒、不耐烦和冷漠等情绪,这些情绪被认为是关键的非人化因素。结果结果表明,这些情绪在护士对患者的认知中普遍存在。有趣的是,虽然重症监护室的护士经常让家属参与病人护理,从而提高了满意度,但病房部门的护士有时却认为病人或家属的关系是障碍。尽管如此,仍有 66% 的护士对所提供的护理表示满意,而 12% 的护士对所提供的护理漠不关心。为解决这一问题,研究建议加强护理自主权和教育,营造积极的工作环境。护士对自己的看法直接影响到他们对病人的治疗。
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引用次数: 0
Ketogenic therapies in Parkinson's disease, Alzheimer's disease, and mild cognitive impairment: An integrative review 生酮疗法治疗帕金森病、阿尔茨海默病和轻度认知障碍:一项综合综述
IF 2.2 4区 医学 Q1 NURSING Pub Date : 2023-10-28 DOI: 10.1016/j.apnr.2023.151745
Susan Price MSN, RN, FNP-BC , Todd M. Ruppar PhD, RN, FAAN

Background

Ketogenic therapies have shown benefit for seizure reduction in epilepsy but their impact on other neurologic conditions is less known. In this literature review, the efficacy of ketogenic therapies were assessed in Parkinson's disease (PD), Alzheimer's disease (AD), and mild cognitive impairment (MCI).

Methods

A literature search was conducted using PubMed, Scopus, and Google Scholar focusing on ketogenic therapies in PD, AD, and MCI.

Results

A total of 2565 records were identified with a total of 15 studies (3 for PD and 12 for MCI/AD) meeting criteria for analysis. The ketogenic diet was used in all the PD studies and did show significant improvement in motor function either through vocal quality, gait, freezing, tremor, and/or balance. A variety of ketogenic therapies were utilized in the MCI and AD groups including a ketogenic diet, low-carbohydrate diet, modified Adkins diet, Mediterranean diet with coconut oil supplementation, a ketogenic diet with a ketogenic medium chain triglyceride (kMCT) supplement, as well as ketogenic supplements including a ketogenic drink with kMCT, oral ketogenic compounds (Axona and AC-1202), and MCT oil or emulsion. The ketogenic diet independently showed a non-significant trend towards improvement in cognition. The Mediterranean diet, modified Adkins diet, and low-carbohydrate diet showed statistically significant improvements in some, although not all, of their cognitive measures. Use of ketogenic supplements, drinks, or compounds showed variable results in the AD and MCI groups. The Axona and AC-1202 compounds showed no significant improvement in cognition at the end of their respective 90-day trials. Most MCT supplements did show cognitive improvements, although only after 6 months of adherence. Adherence to the intervention was problematic in most of the diet studies.

Conclusion

Ketogenic therapies have promise in PD, AD, and MCI for symptom improvement although larger studies are needed to support their implementation in clinical practice.

生酮疗法对减少癫痫发作有好处,但对其他神经系统疾病的影响尚不清楚。在这篇文献综述中,我们评估了生酮疗法在帕金森病(PD)、阿尔茨海默病(AD)和轻度认知障碍(MCI)中的疗效。方法通过PubMed、Scopus和Google Scholar检索PD、AD和MCI的生酮疗法相关文献。结果共获得2565份记录,其中符合分析标准的研究15份(PD 3份,MCI/AD 12份)。在所有PD研究中都使用了生酮饮食,并且通过声音质量,步态,冻结,震颤和/或平衡确实显示出运动功能的显着改善。在MCI和AD组中使用了各种生酮疗法,包括生酮饮食、低碳水化合物饮食、改良阿德金斯饮食、地中海饮食加椰子油补充剂、生酮饮食加生酮中链甘油三酯(kMCT)补充剂,以及生酮补充剂,包括含kMCT的生酮饮料、口服生酮化合物(Axona和AC-1202)和MCT油或乳剂。生酮饮食对认知的改善没有明显的趋势。地中海饮食、改良阿德金斯饮食和低碳水化合物饮食在某些(尽管不是全部)认知测量方面显示出统计学上显著的改善。在AD组和MCI组中,使用生酮补充剂、饮料或化合物显示出不同的结果。Axona和AC-1202化合物在各自90天的试验结束时,对认知能力没有显着改善。大多数MCT补充剂确实显示出认知能力的改善,尽管只是在坚持服用6个月之后。在大多数饮食研究中,坚持干预是有问题的。结论生酮疗法在PD、AD和MCI中有改善症状的希望,尽管需要更大规模的研究来支持其在临床实践中的实施。
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引用次数: 0
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Applied Nursing Research
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