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Machine Learning System for the Effective Diagnosis and Survival Prediction of Breast Cancer Patients 用于有效诊断和预测乳腺癌患者生存期的机器学习系统
Pub Date : 2024-02-14 DOI: 10.3991/ijoe.v20i02.42883
Arturo Gago, Jean Marko Aguirre, Lenis Wong
Breast cancer is one of the most significant global health challenges. Effective diagnosis and prognosis prediction are crucial for improving patient outcomes in the case of this disease. As machine learning (ML) has significantly improved prediction models in many disciplines, the goal of this study is to develop a ML system for medical specialists that can accurately predict tumor diagnosis and patient survival for breast cancer patients. For the training of diagnosis and survival prediction, five algorithmic models—decision tree (DT), random forest (RF), naive bayes (NB), support vector machines (SVMs), and gradient boosting—were trained with 569 records from the Breast Cancer Wisconsin dataset and 1,980 records from the Breast Cancer Gene Expression Profiles dataset. The results showed that the NB model exhibited better performance for tumor diagnosis, achieving an accuracy of 95.0%, while RF presented the best results for patient survival, with an accuracy of 76.0%. A survey of medical experts’ experience with the resulting system showed high scores in reliability, performance, satisfaction, usability, and efficiency, confirming that ML systems have the potential to improve breast cancer patient outcomes.
乳腺癌是全球健康面临的最重大挑战之一。有效的诊断和预后预测对于改善这种疾病的患者预后至关重要。由于机器学习(ML)在许多学科中都极大地改进了预测模型,因此本研究的目标是为医学专家开发一种 ML 系统,以准确预测乳腺癌患者的肿瘤诊断和生存期。在诊断和生存预测的训练中,使用了五种算法模型--决策树(DT)、随机森林(RF)、奈夫贝叶斯(NB)、支持向量机(SVM)和梯度提升--对威斯康星乳腺癌数据集的 569 条记录和乳腺癌基因表达谱数据集的 1,980 条记录进行了训练。结果表明,NB 模型在肿瘤诊断方面表现更佳,准确率达到 95.0%,而 RF 模型在患者存活率方面表现最佳,准确率达到 76.0%。对医学专家使用该系统的经验进行的调查显示,该系统在可靠性、性能、满意度、可用性和效率方面都获得了高分,这证实了 ML 系统具有改善乳腺癌患者预后的潜力。
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引用次数: 0
Histopathological Image Classification Using Convolutional Neural Networks for Detection of Metastatic Breast Cancer in Lymph Nodes 利用卷积神经网络进行组织病理学图像分类以检测淋巴结转移性乳腺癌
Pub Date : 2024-02-14 DOI: 10.3991/ijoe.v20i02.46789
Diego Alberto Cadillo-Laurentt, Ernesto Paiva-Peredo
Breast cancer is currently one of the most diagnosed oncological diseases worldwide, with thousands of new cases per year. Early detection and identifying its progression are key to overcoming the mortality rate. A recurrent test, to determine how far the disease has spread throughout the patient’s body, is the histological analysis of the sentinel lymph node near the breast. Although an expert pathologist performs this, it is usually an exhausting and time-consuming task, with a high possibility of error. This work presents a method to detect breast cancer metastasis through histological imaging of sentinel lymph nodes using convolutional neural networks. In this study, the performance of three models DenseNet-121, DenseNet-169 and DenseNet-201 are tested and compared. Experimental results indicated that the accuracy, precision, sensitivity and specificity (97.93%, 97.4%, 97.48% and 98.24%) of DenseNet-201 could reduce pathologist errors during the diagnostic process or serve as a second opinion tool.
乳腺癌是目前全球诊断率最高的肿瘤疾病之一,每年新增病例数以千计。早期发现并确定其进展是降低死亡率的关键。为了确定疾病在患者全身的扩散程度,一项经常性检查是对乳房附近的前哨淋巴结进行组织学分析。虽然这项工作由病理专家完成,但通常是一项耗时耗力的工作,而且极有可能出错。本研究提出了一种利用卷积神经网络通过前哨淋巴结组织学成像检测乳腺癌转移的方法。本研究测试并比较了 DenseNet-121、DenseNet-169 和 DenseNet-201 三种模型的性能。实验结果表明,DenseNet-201 的准确度、精确度、灵敏度和特异性(分别为 97.93%、97.4%、97.48% 和 98.24%)可以减少病理学家在诊断过程中的错误,或作为第二意见工具。
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引用次数: 0
An Integrated Multimodal Deep Learning Framework for Accurate Skin Disease Classification 用于准确皮肤病分类的多模态深度学习综合框架
Pub Date : 2024-02-14 DOI: 10.3991/ijoe.v20i02.43795
S. Hamida, Driss Lamrani, Mohammed Amine Bouqentar, Oussama El Gannour, B. Cherradi
In order to effectively treat skin diseases, an accurate and prompt diagnosis is required. In this article, a novel method for classifying skin disorders using a multimodal classifier is presented. The proposed classifier utilizes multiple information sources to enhance the accuracy of disease classification. It incorporates images of skin lesions and patient-specific data. The multimodal classifier simultaneously classifies diseases by combining image and structured data inputs. The effectiveness of the proposed classifier was evaluated using the ISIC 2018 dataset, which includes images and clinical data for seven categories of skin diseases. The results indicate that the proposed model outperforms conventional single-modal and single-task classifiers, achieving an accuracy of 98.66% for image classification and 94.40% for clinical data classification. In addition, we compare the performance of the proposed model with that of other methodologies, demonstrating its superiority. Despite yielding promising results, the proposed method has limitations in terms of data requirements and generalizability. Future research directions include incorporating additional information sources, investigating genetic data integration, and applying the method to various medical conditions. This study illustrates the potential of integrating multimodal techniques with transfer learning in deep neural networks to enhance the classification accuracy of cutaneous diseases.
为了有效治疗皮肤病,需要准确及时的诊断。本文介绍了一种利用多模态分类器对皮肤病进行分类的新方法。所提出的分类器利用多种信息源来提高疾病分类的准确性。它结合了皮肤病变的图像和病人的具体数据。多模态分类器通过结合图像和结构化数据输入,同时对疾病进行分类。使用 ISIC 2018 数据集对所提议的分类器的有效性进行了评估,该数据集包括七类皮肤病的图像和临床数据。结果表明,所提出的模型优于传统的单模态和单任务分类器,其图像分类准确率达到 98.66%,临床数据分类准确率达到 94.40%。此外,我们还将所提模型的性能与其他方法进行了比较,证明了其优越性。尽管提出的方法取得了可喜的成果,但在数据要求和通用性方面仍有局限。未来的研究方向包括纳入更多信息源、研究基因数据整合以及将该方法应用于各种医疗状况。本研究说明了在深度神经网络中将多模态技术与迁移学习相结合以提高皮肤疾病分类准确性的潜力。
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引用次数: 0
An Integrated Multimodal Deep Learning Framework for Accurate Skin Disease Classification 用于准确皮肤病分类的多模态深度学习综合框架
Pub Date : 2024-02-14 DOI: 10.3991/ijoe.v20i02.43795
S. Hamida, Driss Lamrani, Mohammed Amine Bouqentar, Oussama El Gannour, B. Cherradi
In order to effectively treat skin diseases, an accurate and prompt diagnosis is required. In this article, a novel method for classifying skin disorders using a multimodal classifier is presented. The proposed classifier utilizes multiple information sources to enhance the accuracy of disease classification. It incorporates images of skin lesions and patient-specific data. The multimodal classifier simultaneously classifies diseases by combining image and structured data inputs. The effectiveness of the proposed classifier was evaluated using the ISIC 2018 dataset, which includes images and clinical data for seven categories of skin diseases. The results indicate that the proposed model outperforms conventional single-modal and single-task classifiers, achieving an accuracy of 98.66% for image classification and 94.40% for clinical data classification. In addition, we compare the performance of the proposed model with that of other methodologies, demonstrating its superiority. Despite yielding promising results, the proposed method has limitations in terms of data requirements and generalizability. Future research directions include incorporating additional information sources, investigating genetic data integration, and applying the method to various medical conditions. This study illustrates the potential of integrating multimodal techniques with transfer learning in deep neural networks to enhance the classification accuracy of cutaneous diseases.
为了有效治疗皮肤病,需要准确及时的诊断。本文介绍了一种利用多模态分类器对皮肤病进行分类的新方法。所提出的分类器利用多种信息源来提高疾病分类的准确性。它结合了皮肤病变的图像和病人的具体数据。多模态分类器通过结合图像和结构化数据输入,同时对疾病进行分类。使用 ISIC 2018 数据集对所提议的分类器的有效性进行了评估,该数据集包括七类皮肤病的图像和临床数据。结果表明,所提出的模型优于传统的单模态和单任务分类器,其图像分类准确率达到 98.66%,临床数据分类准确率达到 94.40%。此外,我们还将所提模型的性能与其他方法进行了比较,证明了其优越性。尽管提出的方法取得了可喜的成果,但在数据要求和通用性方面仍有局限。未来的研究方向包括纳入更多信息源、研究基因数据整合以及将该方法应用于各种医疗状况。本研究说明了在深度神经网络中将多模态技术与迁移学习相结合以提高皮肤疾病分类准确性的潜力。
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引用次数: 0
Assessing Subjective Visual Vertical Reliability: A Comparison of the “Bucket Test,” a Mobile App, and a Virtual System 评估主观视觉垂直可靠性:水桶测试"、移动应用程序和虚拟系统的比较
Pub Date : 2024-02-14 DOI: 10.3991/ijoe.v20i02.45981
Mohammed Waly, Fahad Alshammari, Maryam E. Alshammari, Mohammed Algahtany
The subjective visual vertical (SVV) is a potential indicator of vestibular dysfunction as it assesses an individual’s perception of a vertical line. Despite this, and as a result of specific logistical impediments, SVV has not entered standard clinical practice. Dizziness is the third most common clinical complaint by patients (20%) in outpatient offices. It adversely affects the patient’s life and is often accompanied by intensive healthcare. This study aims to determine whether the bucket test and mobile phone app are as reliable as the Virtual SVV system in assessing the SVV. This study involves four types of investigation to determine the relationship or difference among three tests, including their performance comparison, descriptive analysis, one-way ANOVA test, receiver operating characteristic (ROC) curve, and correlation analysis. After organizing the raw data from 207 healthy volunteer participants for 8 trials, it was found that 59% were female and 41% were male. The data was analyzed utilizing the SPSS program. The test performance is measured using the ROC curve, and the results indicate that the bucket with the highest ROC coefficient is 0.72.
主观视觉垂直度(SVV)是前庭功能障碍的一个潜在指标,因为它评估的是个人对垂直线的感知。尽管如此,由于特定的后勤障碍,SVV 尚未进入标准临床实践。头晕是门诊患者第三大常见的临床主诉(20%)。它对患者的生活造成了不利影响,而且往往伴随着密集的医疗服务。本研究旨在确定水桶测试和手机应用在评估 SVV 方面是否与虚拟 SVV 系统一样可靠。本研究通过四种类型的调查来确定三种测试之间的关系或差异,包括它们的性能比较、描述性分析、单因素方差分析、接收者操作特征曲线(ROC)和相关性分析。在整理了 207 名健康志愿者参加 8 次试验的原始数据后,发现 59% 为女性,41% 为男性。数据使用 SPSS 程序进行分析。使用 ROC 曲线衡量测试性能,结果表明 ROC 系数最高的桶为 0.72。
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引用次数: 0
Histopathological Image Classification Using Convolutional Neural Networks for Detection of Metastatic Breast Cancer in Lymph Nodes 利用卷积神经网络进行组织病理学图像分类以检测淋巴结转移性乳腺癌
Pub Date : 2024-02-14 DOI: 10.3991/ijoe.v20i02.46789
Diego Alberto Cadillo-Laurentt, Ernesto Paiva-Peredo
Breast cancer is currently one of the most diagnosed oncological diseases worldwide, with thousands of new cases per year. Early detection and identifying its progression are key to overcoming the mortality rate. A recurrent test, to determine how far the disease has spread throughout the patient’s body, is the histological analysis of the sentinel lymph node near the breast. Although an expert pathologist performs this, it is usually an exhausting and time-consuming task, with a high possibility of error. This work presents a method to detect breast cancer metastasis through histological imaging of sentinel lymph nodes using convolutional neural networks. In this study, the performance of three models DenseNet-121, DenseNet-169 and DenseNet-201 are tested and compared. Experimental results indicated that the accuracy, precision, sensitivity and specificity (97.93%, 97.4%, 97.48% and 98.24%) of DenseNet-201 could reduce pathologist errors during the diagnostic process or serve as a second opinion tool.
乳腺癌是目前全球诊断率最高的肿瘤疾病之一,每年新增病例数以千计。早期发现并确定其进展是降低死亡率的关键。为了确定疾病在患者全身的扩散程度,一项经常性检查是对乳房附近的前哨淋巴结进行组织学分析。虽然这项工作由病理专家完成,但通常是一项耗时耗力的工作,而且极有可能出错。本研究提出了一种利用卷积神经网络通过前哨淋巴结组织学成像检测乳腺癌转移的方法。本研究测试并比较了 DenseNet-121、DenseNet-169 和 DenseNet-201 三种模型的性能。实验结果表明,DenseNet-201 的准确度、精确度、灵敏度和特异性(分别为 97.93%、97.4%、97.48% 和 98.24%)可以减少病理学家在诊断过程中的错误,或作为第二意见工具。
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引用次数: 0
Study of Free Fall Using an Ultra-Concurrent Laboratory at the University 利用大学超电流实验室研究自由落体运动
Pub Date : 2024-02-14 DOI: 10.3991/ijoe.v20i02.43099
Eduardo Arias Navarro, Cesar Nahuel Moya, Fiorella Lizano-Sánchez, Carlos Arguedas-Matarrita, César Eduardo Mora Ley, Ignacio Idoyaga
This article presents the results of the educational use of an ultra-concurrent laboratory during the second semester of 2022, in the Cisale Chair of the Common Cycle of the University of Buenos Aires in order to strengthen the experimental scenarios and quality of the process in the teaching of physics. For this purpose, a quantitative descriptive study in which 68 students participated was carried out. This allowed establishing a significant scenario with the implementation of the ultra-concurrent free-fall laboratory to enhance experimental development in physics teaching processes. It is concluded that remote laboratories are promising technologies for teaching physics at the university level. However, it should be clarified that the impact of an educational innovation does not only depend on the technology used, but also on the didactic design with which it is approached.
本文介绍了布宜诺斯艾利斯大学共同周期 Cisale 教席在 2022 年第二学期使用超导实验室进行教学的结果,目的是加强物理教学过程中的实验场景和质量。为此,开展了一项有 68 名学生参与的定量描述性研究。研究结果表明,在物理教学过程中,通过实施超高速自由落体实验室来加强实验发展,可以建立一个重要的实验场景。研究得出结论,远程实验室是大学物理教学中大有可为的技术。不过,需要说明的是,教育创新的影响不仅取决于所使用的技术,还取决于教学设计。
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引用次数: 0
Static, Dynamic, and High Cycle Fatigue Analysis of Crossed Spherical Gearing for Robotic Arm Ball Joint: A Finite Element Analysis Approach 机器人手臂球形关节交叉球面齿轮的静态、动态和高循环疲劳分析:有限元分析方法
Pub Date : 2024-02-14 DOI: 10.3991/ijoe.v20i02.46817
José L. Serna-Landivar, Madelaine Violeta Risco Sernaqué, Ana Beatriz Rivas Moreano, William C. Algoner, Daniela M. Anticona-Valderrama, Walter Enrique Zúñiga Porras, Carlos Oliva Guevara
Crossed spherical gearing is used in the joints of robotic arm prostheses and allows mobility in 3 degrees of freedom. This paper aims to evaluate the design of a cross-spherical gear with three different materials, PEEK, AISI 304L, and Ti-6Al-4V, for a robotic arm prosthesis by finite element analysis. ANSYS mechanical software (version 2021 R1) was used to perform the static analysis and evaluate the deformations and stresses, modal analysis of natural frequencies and vibration modes, and high cycle fatigue analysis to determine fatigue resistance. The results obtained in the static analysis show that the maximum stresses are in the same zones for the three materials and have similar values. However, the Ti-6Al-4V and ASI 304L materials have a higher safety factor than PEEK, with a value of 5.17. In conclusion, the crossed spherical gearing is numerically validated using the finite element analysis so that the prototype can be later manufactured at an experimental level, and the values obtained for the crossed spherical gearing of the robotic arm prosthesis can be verified.
交叉球形齿轮用于机械手臂假肢的关节,可实现 3 个自由度的移动。本文旨在通过有限元分析,评估采用 PEEK、AISI 304L 和 Ti-6Al-4V 三种不同材料的交叉球形齿轮在机械臂假肢中的设计。ANSYS 机械软件(2021 R1 版)用于进行静态分析,评估变形和应力,对固有频率和振动模式进行模态分析,以及进行高循环疲劳分析以确定抗疲劳性。静态分析结果表明,三种材料的最大应力位于相同区域,且应力值相似。不过,Ti-6Al-4V 和 ASI 304L 材料的安全系数高于 PEEK,达到 5.17。总之,利用有限元分析对交叉球形齿轮进行了数值验证,以便以后在实验水平上制造原型,并验证机械臂假肢交叉球形齿轮所获得的数值。
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引用次数: 0
Effectiveness of an E-learning System for Emergency Signs and CPR Emergency Preparedness in Marathon Events: A Comparative Study 马拉松赛事中紧急征兆和心肺复苏应急准备电子学习系统的有效性:比较研究
Pub Date : 2024-01-12 DOI: 10.3991/ijoe.v20i01.44927
Pipitton Homla, Pakinee Ariya, Perasuk Worragin, Supicha Niemsup, Kitti Puritat, K. Intawong
This study investigates the implementation, effectiveness, and impact of a unique e-learning system designed specifically for emergency signs and cardiopulmonary resuscitation (CPR) emergency preparedness in marathon events. Our approach introduces the first e-learning system specifically designed for marathon events. It delivers engaging content, including infographic stories, expert lectures, and interactive modules, to provide registered runners with comprehensive knowledge of first aid and emergency signs for CPR. To evaluate the e-learning application, we conducted a comparative experiment during the CMU (Chiang Mai University) marathon with 9,761 participants. We used pre- and post-tests, as well as a survey questionnaire. The results showed significant improvements in participants’ CPR knowledge across all educational backgrounds. The integration of e-learning into the registration process contributed to a safer marathon environment, as participants felt more confident in handling emergencies. Approximately 85% of participants expressed a willingness to recommend the e-learning system. This increased confidence among participants in handling emergencies benefits both runners and marathon organizers by enhancing safety measures and emergency response during events. In conclusion, our findings strongly support the integration of e-learning into the registration process for marathon events. Recommendations based on our research include providing comprehensive guidelines for other marathon events, instilling stakeholder confidence, and emphasizing the suitability of e-learning for medium- to largescale events. However, caution is advised for smaller events due to potential complexities and costs. Additionally, we suggest limiting the validity of e-certificates to ensure that participants have up-to-date CPR knowledge.
本研究调查了一个独特的电子学习系统的实施情况、效果和影响,该系统是专门为马拉松赛事中的紧急征兆和心肺复苏(CPR)应急准备而设计的。我们的方法引入了首个专为马拉松赛事设计的电子学习系统。该系统提供引人入胜的内容,包括信息图表故事、专家讲座和互动模块,为注册跑步者提供全面的急救知识和心肺复苏术应急标志。为了评估该电子学习应用程序,我们在 CMU(清迈大学)马拉松赛期间进行了一次对比实验,共有 9761 人参加。我们使用了前后测试以及调查问卷。结果显示,不同教育背景的参与者在心肺复苏知识方面都有了明显提高。将电子学习融入注册流程有助于营造更安全的马拉松环境,因为参与者对处理紧急情况更有信心。约 85% 的参与者表示愿意推荐电子学习系统。参赛者对处理紧急情况的信心增强了,这对跑步者和马拉松赛事组织者都有好处,因为他们可以在赛事期间加强安全措施和应急反应。总之,我们的研究结果强烈支持将电子学习融入马拉松赛事的注册流程。根据我们的研究提出的建议包括:为其他马拉松赛事提供全面的指导原则,增强利益相关者的信心,并强调电子学习适用于大中型赛事。不过,由于潜在的复杂性和成本问题,建议对小型赛事采取谨慎态度。此外,我们建议限制电子证书的有效性,以确保参与者掌握最新的心肺复苏知识。
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引用次数: 0
A State Table SPHIT Approach for Modified Curvelet-based Medical Image Compression 基于修正曲线的医学图像压缩的状态表 SPHIT 方法
Pub Date : 2024-01-12 DOI: 10.3991/ijoe.v20i01.41363
N. H. Ja'afar, Afandi Ahmad, S. Safie
Medical imaging plays a significant role in clinical practice. Storing and transferring a large volume of images can be complex and inefficient. This paper presents the development of a new compression technique that combines the fast discrete curvelet transform (FDCvT) with state table set partitioning in the hierarchical trees (STS) encoding scheme. The curvelet transform is an extension of the wavelet transform algorithm that represents data based on scale and position. Initially, the medical image was decomposed using the FDCvT algorithm. The FDCvT algorithm creates symmetrical values for the detail coefficients, and these coefficients are modified to improve the efficiency of the algorithm. The curvelet coefficients are then encoded using the STS and differential pulse-code modulation (DPCM). The greatest amount of energy is contained in the coarse coefficients, which are encoded using the DPCM method. The finest and modified detail coefficients are encoded using the STS method. A variety of medical modalities, including computed tomography (CT), positron emission tomography (PET), and magnetic resonance imaging (MRI), are used to verify the performance of the proposed technique. Various quality metrics, including peak signal-to-noise ratio (PSNR), compression ratio (CR), and structural similarity index (SSIM), are used to evaluate the compression results. Additionally, the computation time for the encoding (ET) and decoding (DT) processes is measured. The experimental results showed that the PET image obtained higher values of the PSNR and CR. The CT image provides high quality for the reconstructed image, with an SSIM value of 0.96 and the fastest ET of 0.13 seconds. The MRI image has the shortest DT, which is 0.23 seconds.
医学成像在临床实践中发挥着重要作用。存储和传输大量图像可能既复杂又低效。本文介绍了一种新的压缩技术,它将快速离散小曲线变换(FDCvT)与分层树(STS)编码方案中的状态表集分割相结合。小曲线变换是小波变换算法的扩展,它根据尺度和位置来表示数据。最初,医学影像采用 FDCvT 算法进行分解。FDCvT 算法为细节系数创建对称值,并对这些系数进行修改,以提高算法的效率。然后使用 STS 和差分脉冲编码调制 (DPCM) 对 curvelet 系数进行编码。粗系数包含的能量最大,采用 DPCM 方法对其进行编码。最精细和经过修改的细节系数则使用 STS 方法进行编码。包括计算机断层扫描 (CT)、正电子发射断层扫描 (PET) 和磁共振成像 (MRI) 在内的各种医疗模式都被用来验证所提技术的性能。各种质量指标,包括峰值信噪比(PSNR)、压缩比(CR)和结构相似性指数(SSIM),都被用来评估压缩结果。此外,还测量了编码(ET)和解码(DT)过程的计算时间。实验结果表明,PET 图像获得了较高的 PSNR 值和 CR 值。CT 图像的重建图像质量较高,SSIM 值为 0.96,最快的 ET 为 0.13 秒。MRI 图像的 DT 最短,为 0.23 秒。
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引用次数: 0
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International Journal of Online and Biomedical Engineering (iJOE)
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