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Authors’ response 作者的答复
IF 2.7 2区 医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2024-09-01 DOI: 10.1016/j.ajodo.2024.06.005
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引用次数: 0
Efficacy of peptide-based enamel coatings in the prevention of demineralization using fixed orthodontic brackets in a rat model 肽基珐琅质涂层在大鼠模型中使用固定正畸托槽防止脱矿的功效。
IF 2.7 2区 医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2024-09-01 DOI: 10.1016/j.ajodo.2024.05.016

Introduction

White spot lesions (WSLs) represent a prominent pathology encountered during orthodontic treatment, originating from enamel demineralization induced by the accumulation of bacterial biofilms. The previously developed bioinspired enamel coating form of self-assembling antimicrobial peptide D-GL13K exhibited antimicrobial activity and enhanced acid impermeability, offering a potential solution to prevent demineralization. The primary aim of this investigation is to assess the in vivo anti-demineralization properties and biocompatibility of the D-GL13K coating.

Methods

A rat model was developed to assess the antimicrobial enamel coating during fixed orthodontic treatment. The anti-demineralization efficacy attributed to the D-GL13K coating was evaluated by employing optical coherence tomography, Vickers microhardness testing, and scanning electron microscopy. The biocompatibility of the D-GL13K coating was investigated through histologic observations of vital organs and tissues using hematoxylin and eosin.

Results

The D-GL13K coating demonstrated significant anti-demineralization effects, evidenced by reduced demineralization depth analyzed through optical coherence tomography and enhanced Vickers hardness than in the noncoated control group, showcasing the coating’s potential to protect teeth from WSLs. Scanning electron microscopy analysis further elucidated the diminished enamel damage observed in the group treated with D-GL13K. Importantly, histologic examination of vital organs and tissues using hematoxylin and eosin staining revealed no overt disparities between the D-GL13K coated group and the noncoated control group.

Conclusions

The D-GL13K enamel coating demonstrated promising anti-demineralization and biocompatibility properties in a rat model, thereby suggesting its potential for averting WSLs after orthodontic interventions. Further research in human clinical settings is needed to evaluate the coating’s long-term efficacy.

简介白斑病变(WSLs)是正畸治疗过程中遇到的一种突出病理现象,源于细菌生物膜积累引起的釉质脱矿。之前开发的自组装抗菌肽 D-GL13K 的生物启发釉质涂层具有抗菌活性和更强的抗酸渗透性,为防止脱矿提供了一种潜在的解决方案。本研究的主要目的是评估 D-GL13K 涂层的体内抗矿化特性和生物相容性:方法:建立了一个大鼠模型来评估固定正畸治疗过程中的抗菌釉质涂层。采用光学相干断层扫描、维氏显微硬度测试和扫描电子显微镜对 D-GL13K 涂层的抗脱矿功效进行了评估。通过使用苏木精和伊红对重要器官和组织进行组织学观察,研究了 D-GL13K 涂层的生物相容性:结果:与无涂层对照组相比,D-GL13K 涂层通过光学相干断层扫描分析表明具有显著的抗脱矿效果,脱矿深度降低,维氏硬度增强,这表明该涂层具有保护牙齿免受 WSL 侵蚀的潜力。扫描电子显微镜分析进一步阐明了在使用 D-GL13K 处理的组别中观察到的牙釉质损伤的减少。重要的是,使用苏木精和伊红染色法对重要器官和组织进行的组织学检查显示,D-GL13K涂层组和未涂层对照组之间没有明显差异:结论:D-GL13K釉质涂层在大鼠模型中表现出了良好的抗脱矿和生物相容性,从而表明它具有在正畸干预后避免WSL的潜力。要评估该涂层的长期疗效,还需要在人类临床环境中开展进一步的研究。
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引用次数: 0
The treatment effects of maxillary asymmetric mechanics with the use of the mesial-distalslider: A retrospective study 使用中-远端滑动器治疗上颌不对称力学的效果:回顾性研究
IF 2.7 2区 医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2024-09-01 DOI: 10.1016/j.ajodo.2024.05.013

Introduction

This study had 2 objectives: (1) to evaluate the clinical efficacy of the Mesial-Distalslider (MD) appliance when used for simultaneous maxillary molar mesialization and distalization in patients with a maxillary asymmetrical relationship and (2) to compare the outcomes with those achieved using the unilateral Mesialslider (UM) appliance.

Methods

The sample included 40 subjects (25 females and 15 males) with a mean age of 22 years (range, 8-55 years). The patients were divided into 2 groups: 20 patients treated with an MD appliance (group 1) and a group of 20 patients treated with a UM appliance (group 2). Superimposition of digital dental models using regions of interest on the palate was performed to evaluate the 3-dimensional molar movements, the proclination or retroclination of the maxillary incisors, and the displacement of the maxillary midline.

Results

At the end of the treatment, the MD group’s total movements were 4.5 ± 2.2 mm (sagittal), −0.4 ± 2.4 mm (transverse), and 0.3 ± 0.9 mm (vertical) along the mesialization side and −2.4 ± 1.7 mm (sagittal), −0.5 ± 1.5 mm (transverse), and 0.2 ± 1.4 (vertical) along the distalization side. UM group total movements were 5.5 ± 3.6 mm (sagittal), −0.4 ± 2.7 mm (transverse), and 0.1 ± 2.0 mm (vertical). Incisor displacements were minimal. No statistically significant differences were found between the MD and UM groups for all the parameters.

Conclusions

The use of the MD enables controlled movements in the sagittal direction with negligible dental side effects in the other planes (transverse and vertical). Furthermore, it facilitates asymmetrical movements simultaneously in the desired direction without the patient’s compliance and provides good anchorage control.

前言:本研究有两个目的:(1)评估中-远端滑动器(MD)矫治器在上颌不对称患者中用于同时进行上颌磨牙中轴化和远端化的临床疗效;(2)比较与单侧中-远端滑动器(UM)矫治器的疗效:样本包括 40 名受试者(25 名女性和 15 名男性),平均年龄为 22 岁(8-55 岁不等)。患者分为两组:20 名使用 MD矫治器治疗的患者(第一组)和 20 名使用 UM矫治器治疗的患者(第二组)。利用腭部感兴趣区进行数字牙科模型叠加,以评估臼齿的三维移动、上颌切牙的前倾或后倾以及上颌中线的移位:治疗结束时,MD组的总移动量为中轴侧4.5±2.2毫米(矢状)、-0.4±2.4毫米(横向)和0.3±0.9毫米(垂直),远轴侧-2.4±1.7毫米(矢状)、-0.5±1.5毫米(横向)和0.2±1.4毫米(垂直)。UM 组的总移动量为 5.5 ± 3.6 毫米(矢状)、-0.4 ± 2.7 毫米(横向)和 0.1 ± 2.0 毫米(垂直)。切牙位移很小。MD 组和 UM 组在所有参数上均无显着统计学差异:使用 MD 可以控制矢状面方向的移动,而对其他平面(横向和纵向)的牙齿副作用可以忽略不计。此外,它还能在不影响患者顺应性的情况下,同时在所需方向上进行非对称移动,并提供良好的锚固控制。
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引用次数: 0
Authors’ response 作者的答复
IF 2.7 2区 医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2024-09-01 DOI: 10.1016/j.ajodo.2024.06.013
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引用次数: 0
Evaluation of the accuracy of automated tooth segmentation of intraoral scans using artificial intelligence-based software packages 评估使用基于人工智能的软件包对口内扫描进行自动牙齿分割的准确性。
IF 2.7 2区 医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2024-09-01 DOI: 10.1016/j.ajodo.2024.05.015

Introduction

The accuracy of tooth segmentation in intraoral scans is crucial for performing virtual setups and appliance fabrication. Hence, the objective of this study was to estimate and compare the accuracy of automated tooth segmentation generated by the artificial intelligence of dentOne software (DIORCO Co, Ltd, Yongin, South Korea) and Medit Ortho Simulation software (Medit Corp, Seoul, South Korea).

Methods

Twelve maxillary and mandibular pretreatment dental scan sets comprising 286 teeth were collected for this investigation from the archives of the Department of Orthodontics, Faculty of Dentistry, Alexandria University. The scans were imported as standard tessellation language files into both dentOne and Medit Ortho Simulation software. Automatic segmentation was run on each software. The number of successfully segmented teeth vs failed segmentations was recorded to determine the success rate of automated segmentation of each program. Evaluation of success and/or failure was based on the software’s identification of the teeth and the quality of the segmentation. The mesiodistal tooth width measurements after segmentation using both tested software programs were compared with those measured on the unsegmented scan using Meshmixer software (Autodesk, San Rafael, Calif). The unsegmented scans served as the reference standard.

Results

A total of 288 teeth were examined. Successful identification rates were 99% and 98.3% for Medit and dentOne, respectively. Success rates of segmenting the lingual surfaces of incisors were significantly higher in Medit than in dentOne (93.7% vs 66.7%, respectively; P <0.001). DentOne overestimated the mesiodistal width of canines (0.11 mm, P = 0.032), premolars (0.22 mm, P < 0.001), and molars (0.14 mm, P = 0.043) compared with the reference standard, whereas Medit overestimated the mesiodistal width of premolars only (0.13 mm, P = 0.006). Bland-Altman plots showed that mesiodistal tooth width agreement limits exceeded 0.2 mm between each software and the reference standard.

Conclusions

Both artificial intelligence-segmentation software demonstrated acceptable accuracy in tooth segmentation. There is a need for improvement in segmenting incisor lingual tooth surfaces in dentOne. Both software programs tended to overestimate the mesiodistal widths of segmented teeth, particularly the premolars. Artificial intelligence-segmentation needs to be manually adjusted by the operator to ensure accuracy. However, this still does not solve the problem of proximal surface reconstruction by the software.

简介口内扫描中牙齿分割的准确性对于进行虚拟设置和矫形器制作至关重要。因此,本研究的目的是评估和比较由 dentOne 软件(DIORCO Co, Ltd,韩国龙仁市)和 Medit Ortho Simulation 软件(Medit Corp,韩国首尔市)的人工智能生成的自动牙齿分割的准确性:本次调查从亚历山大大学牙科学院正畸学系的档案中收集了 12 套上颌和下颌预处理牙科扫描件,共包含 286 颗牙齿。这些扫描结果以标准细分语言文件的形式导入 dentOne 和 Medit Ortho 仿真软件。每个软件都进行了自动分割。记录成功分割与失败分割的牙齿数量,以确定每个程序自动分割的成功率。成功和/或失败的评估基于软件对牙齿的识别和分割质量。使用两个测试软件程序分割后的齿间宽度测量值与使用 Meshmixer 软件(Autodesk,加州圣拉斐尔)测量的未分割扫描值进行了比较。结果:共检查了 288 颗牙齿。Medit 和 dentOne 的成功识别率分别为 99% 和 98.3%。Medit分割门牙舌面的成功率明显高于dentOne(分别为93.7%和66.7%;P 结论:两款人工智能分割软件都显示出了良好的识别能力:两种人工智能分段软件在牙齿分段方面都表现出了可接受的准确性。dentOne 在切牙舌侧牙齿表面的分割方面有待改进。两个软件程序都倾向于高估被分割牙齿的齿间宽,尤其是前磨牙。人工智能分割需要操作员手动调整,以确保准确性。但是,这仍然不能解决软件重建近端表面的问题。
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引用次数: 0
Efficacy of clear aligners vs rapid palatal expanders on palatal volume and surface area in mixed dentition patients: A randomized controlled trial 透明矫治器与快速腭部扩张器对混合牙患者腭部体积和表面积的影响:随机对照试验。
IF 2.7 2区 医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2024-09-01 DOI: 10.1016/j.ajodo.2024.04.006

Introduction

This study aimed to evaluate the efficacy of Invisalign First Phase I treatment compared with tooth-borne rapid maxillary expansion (RME) in mixed dentition patients by examining changes in palatal volume, palatal surface area, and maxillary interdental transverse measurements.

Methods

In this open-label, 2-arm, parallel, randomized controlled trial, patients with a posterior transverse discrepancy ≤6 mm were allocated into the clear aligner therapy (CAT) group (Invisalign First Phase I treatment) and RME group (tooth-borne RME) according to a computer-generated randomization list immediately before the start of treatment. Digital models were obtained before the beginning of the treatment (T0) and at the end of the retention period/treatment (T1) using an intraoral scanner. Palatal volume was measured as the primary outcome, and palatal surface area and intermolar and intercanine transverse widths at the cusps and gingival level were measured as secondary outcomes. Patients and interventionists were not blinded because of the nature of the intervention.

Results

Out of 50 patients, 41 (19 males and 22 females; mean age, 8.12 ± 1.53 years) were enrolled and divided into 2 groups: 20 in the CAT group and 21 in the RME group. Two participants did not receive the allocated intervention for different reasons (1 patient discontinued the intervention in the CAT group, and another patient was lost to follow-up in the RME group). Thus, 19 patients (5 males and 14 females; mean age, 8.48 ± 1.42 years) were analyzed from the CAT group, and 20 patients (12 males and 8 females; mean age, 7.83 ± 1.19 years) from the RME group. Regarding intragroup comparisons, all outcome measures significantly increased from T0 to T1 in both groups. In terms of intergroup comparisons, there were no significant differences in the variation (Δ) of outcome measures between the 2 groups from T0 to T1, except for the intermolar width at the gingival level (P <0.005). The change in palatal volume was 532.01 ±540.52 mm³ for the RME group and 243.95 ± 473.24 mm³ for the CAT group (P = 0.084), with a moderate effect size (d = 0.57).

Conclusions

RME showed trends favoring better outcomes compared with Invisalign First Phase I treatment across all assessed measures. The only parameter that showed statistically significant differences between the 2 groups was variation in intermolar width at the gingival level, suggesting the occurrence of buccal tipping in patients undergoing Invisalign First Phase I treatment.

Trial Registration

The trial was registered at ClinicalTrial.gov (no. NCT04760535).

简介本研究旨在通过检测腭部体积、腭部表面积和上颌牙间横向测量值的变化,评估混合牙患者接受隐适美第一阶段治疗与牙源性上颌快速扩弓(RME)治疗的疗效:在这项开放标签、双臂、平行、随机对照试验中,后横向差异≤6毫米的患者在治疗开始前根据计算机生成的随机名单被分配到透明矫治器治疗(CAT)组(Invisalign First Phase I治疗)和RME组(牙源性RME)。在治疗开始前(T0)和保持期/治疗结束时(T1),使用口内扫描仪获取数字模型。测量腭部体积是主要结果,测量腭部表面积以及尖牙和牙龈水平的臼间和颊间横向宽度是次要结果。由于干预的性质,患者和干预者都没有盲法:在 50 名患者中,有 41 人(19 名男性和 22 名女性;平均年龄为 8.12 ± 1.53 岁)接受了治疗,并被分为两组:CAT 组 20 人,RME 组 21 人。两名参与者因不同原因未接受所分配的干预(CAT 组中一名患者中断了干预,RME 组中另一名患者失去了随访)。因此,CAT 组分析了 19 名患者(5 名男性和 14 名女性;平均年龄为 8.48 ± 1.42 岁),RME 组分析了 20 名患者(12 名男性和 8 名女性;平均年龄为 7.83 ± 1.19 岁)。在组内比较方面,两组患者从 T0 到 T1 的所有结果指标均显著增加。在组间比较方面,从T0到T1,除了龈水平的磨牙间宽度外,两组之间的结果指标的变化(Δ)没有明显差异(P 结论:RME比RME具有更好的疗效:与隐适美第一阶段治疗相比,RME在所有评估结果中都表现出更优越的效果。两组之间唯一有显著统计学差异的参数是牙龈水平的磨间宽度变化,这表明接受隐适美第一阶段治疗的患者会出现颊侧倾倒:该试验已在ClinicalTrial.gov网站注册(编号:NCT04760535)。
{"title":"Efficacy of clear aligners vs rapid palatal expanders on palatal volume and surface area in mixed dentition patients: A randomized controlled trial","authors":"","doi":"10.1016/j.ajodo.2024.04.006","DOIUrl":"10.1016/j.ajodo.2024.04.006","url":null,"abstract":"<div><h3>Introduction</h3><p>This study aimed to evaluate the efficacy of Invisalign First Phase I treatment compared with tooth-borne rapid maxillary expansion (RME) in mixed dentition patients by examining changes in palatal volume, palatal surface area, and maxillary interdental transverse measurements.</p></div><div><h3>Methods</h3><p>In this open-label, 2-arm, parallel, randomized controlled trial, patients with a posterior transverse discrepancy ≤6 mm were allocated into the clear aligner therapy (CAT) group (Invisalign First Phase I treatment) and RME group (tooth-borne RME) according to a computer-generated randomization list immediately before the start of treatment. Digital models were obtained before the beginning of the treatment (T0) and at the end of the retention period/treatment (T1) using an intraoral scanner. Palatal volume was measured as the primary outcome, and palatal surface area and intermolar and intercanine transverse widths at the cusps and gingival level were measured as secondary outcomes. Patients and interventionists were not blinded because of the nature of the intervention.</p></div><div><h3>Results</h3><p>Out of 50 patients, 41 (19 males and 22 females; mean age, 8.12 ± 1.53 years) were enrolled and divided into 2 groups: 20 in the CAT group and 21 in the RME group. Two participants did not receive the allocated intervention for different reasons (1 patient discontinued the intervention in the CAT group, and another patient was lost to follow-up in the RME group). Thus, 19 patients (5 males and 14 females; mean age, 8.48 ± 1.42 years) were analyzed from the CAT group, and 20 patients (12 males and 8 females; mean age, 7.83 ± 1.19 years) from the RME group. Regarding intragroup comparisons, all outcome measures significantly increased from T0 to T1 in both groups. In terms of intergroup comparisons, there were no significant differences in the variation (Δ) of outcome measures between the 2 groups from T0 to T1, except for the intermolar width at the gingival level (<em>P</em> &lt;0.005). The change in palatal volume was 532.01 ±540.52 mm³ for the RME group and 243.95 ± 473.24 mm³ for the CAT group (<em>P</em> = 0.084), with a moderate effect size (d = 0.57).</p></div><div><h3>Conclusions</h3><p>RME showed trends favoring better outcomes compared with Invisalign First Phase I treatment across all assessed measures. The only parameter that showed statistically significant differences between the 2 groups was variation in intermolar width at the gingival level, suggesting the occurrence of buccal tipping in patients undergoing Invisalign First Phase I treatment.</p></div><div><h3>Trial Registration</h3><p>The trial was registered at <span><span>ClinicalTrial.gov</span><svg><path></path></svg></span> (no. NCT04760535).</p></div>","PeriodicalId":50806,"journal":{"name":"American Journal of Orthodontics and Dentofacial Orthopedics","volume":null,"pages":null},"PeriodicalIF":2.7,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0889540624001446/pdfft?md5=e354af9376b24f966d839c5100e8d3d8&pid=1-s2.0-S0889540624001446-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141789673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Doing what needn’t be done 做不需要做的事
IF 2.7 2区 医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2024-09-01 DOI: 10.1016/j.ajodo.2024.06.002
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引用次数: 0
Long-term profile attractiveness of patients with Class I and Class II malocclusion treated with or without extractions: Overlooked insights? 接受或不接受拔牙治疗的 I 类和 II 类错牙合畸形患者的长期外形吸引力:被忽视的见解?
IF 2.7 2区 医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2024-09-01 DOI: 10.1016/j.ajodo.2024.06.012
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引用次数: 0
Two-stage vs one-stage meta-analysis 两阶段与单阶段荟萃分析
IF 2.7 2区 医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2024-09-01 DOI: 10.1016/j.ajodo.2024.06.003
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引用次数: 0
A longitudinal study of the probability of developing malocclusion in children using a Bayesian analysis 利用贝叶斯分析法对儿童发生错牙合畸形的概率进行纵向研究。
IF 2.7 2区 医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2024-09-01 DOI: 10.1016/j.ajodo.2024.05.011

Introduction

This study evaluated the probability of developing malocclusions in mixed dentition.

Methods

A longitudinal study was conducted with 598 children (aged 5 years) in deciduous dentition. The children were followed for 3 years until mixed dentition (aged 8 years). Overjet, overbite, and transversal relations were evaluated. Bayesian models were used to analyze the data and estimate the parameters.

Results

The parameter θ was used for the distributions, indicating the probability of presenting a given condition with a credibility index (ICr) of 95%. After 3 years of follow-up, 121 children were reevaluated. The results showed that children have a high probability of malocclusion in mixed dentition. There was a higher probability of developing an increased overjet in the mixed dentition of 20.5% (ICr 95%, 13.6-28.4) to 48.3% (ICr 95%, 39.1-57.7) and a higher probability of having a normal overbite in the deciduous dentition and a lower probability in the mixed dentition (ICr 95%, 9.2-21.3).

Conclusions

Considering the probabilistic model of Bayesian analysis, children with normal overjet in the deciduous dentition may show an increased overjet in the mixed dentition. Concerning overbite, children may present an anterior open bite during the transition between deciduous and mixed dentition, as well as self-correction of deep overbite in mixed dentition. Furthermore, they may present a posterior crossbite during the mixed dentition when there is a normal transverse relationship in the deciduous dentition.

简介本研究评估了混合牙列畸形的发生概率:对 598 名儿童(5 岁)的乳牙畸形情况进行了纵向研究。方法: 对 598 名 5 岁乳牙期儿童进行了一项纵向研究,并对这些儿童进行了为期 3 年的跟踪调查,直至他们长出混合牙(8 岁)。对过咬合、过咬合和横向关系进行了评估。贝叶斯模型用于分析数据和估计参数:参数θ用于分布,表示出现特定情况的概率,可信度指数(ICr)为95%。随访 3 年后,对 121 名儿童进行了重新评估。结果显示,混合牙列的儿童出现错合畸形的概率很高。混合牙列中出现过咬合增加的概率较高,从20.5%(ICr 95%,13.6-28.4)到48.3%(ICr 95%,39.1-57.7)不等,落牙列中出现正常过咬合的概率较高,而混合牙列中出现过咬合的概率较低(ICr 95%,9.2-21.3):考虑到贝叶斯分析的概率模型,在萌牙期有正常过咬合的儿童在混合牙列中可能会出现过咬合增加的情况。关于过咬合,儿童在乳牙和混合牙列之间的过渡时期可能会出现前开放咬合,以及在混合牙列中出现深过咬合的自我矫正。此外,在混合牙列中,当乳牙列中的横向关系正常时,他们可能会出现后交叉咬合。
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引用次数: 0
期刊
American Journal of Orthodontics and Dentofacial Orthopedics
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