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CXCL3/TGF-β-Mediated Crosstalk Between CAFs and Tumor Cells Augments RCC Progression and Sunitinib Resistance CXCL3/TGF-β介导的CAFs与肿瘤细胞之间的串联增强了RCC的进展和舒尼替尼的抗药性
iScience
Pub Date : 2024-06-01 DOI: 10.1016/j.isci.2024.110224
Yunxia Wang, Weihong Ding, Wenjing Hao, Luyao Gong, Yeheng Peng, Jun Zhang, Zhiyu Qian, Ke Xu, Weimin Cai, Yuan Gao
{"title":"CXCL3/TGF-β-Mediated Crosstalk Between CAFs and Tumor Cells Augments RCC Progression and Sunitinib Resistance","authors":"Yunxia Wang, Weihong Ding, Wenjing Hao, Luyao Gong, Yeheng Peng, Jun Zhang, Zhiyu Qian, Ke Xu, Weimin Cai, Yuan Gao","doi":"10.1016/j.isci.2024.110224","DOIUrl":"https://doi.org/10.1016/j.isci.2024.110224","url":null,"abstract":"","PeriodicalId":508122,"journal":{"name":"iScience","volume":"136 22","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141408002","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
IL-17A produced by POMC neurons regulates diet-induced obesity POMC 神经元产生的 IL-17A 可调节饮食诱发的肥胖症
iScience
Pub Date : 2024-06-01 DOI: 10.1016/j.isci.2024.110259
Rosa Gallo, A. Teijeiro, Mariana Angulo-Aguado, N. Djouder
{"title":"IL-17A produced by POMC neurons regulates diet-induced obesity","authors":"Rosa Gallo, A. Teijeiro, Mariana Angulo-Aguado, N. Djouder","doi":"10.1016/j.isci.2024.110259","DOIUrl":"https://doi.org/10.1016/j.isci.2024.110259","url":null,"abstract":"","PeriodicalId":508122,"journal":{"name":"iScience","volume":"32 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141406926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The dabABC operon is a marker of C4-alkylated monobactam biosynthesis and responsible for (2S,3R)-diaminobutyrate production dabABC 操作子是 C4-烷基化单内酰胺生物合成的标志，负责生产 (2S,3R)-二氨基丁酸盐
iScience
Pub Date : 2024-04-01 DOI: 10.1016/j.isci.2024.109572
Rongfeng Li, Michael S. Lichstrahl, Trevor A. Zandi, Lukas Kahlert, Craig A. Townsend
{"title":"The dabABC operon is a marker of C4-alkylated monobactam biosynthesis and responsible for (2S,3R)-diaminobutyrate production","authors":"Rongfeng Li, Michael S. Lichstrahl, Trevor A. Zandi, Lukas Kahlert, Craig A. Townsend","doi":"10.1016/j.isci.2024.109572","DOIUrl":"https://doi.org/10.1016/j.isci.2024.109572","url":null,"abstract":"","PeriodicalId":508122,"journal":{"name":"iScience","volume":"337 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140781035","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Exploring the effect of SNX16 on sepsis using bioinformatics and a cecum ligation and puncture (CLP) mouse model 利用生物信息学和盲肠结扎穿刺（CLP）小鼠模型探索 SNX16 对败血症的影响
iScience
Pub Date : 2024-04-01 DOI: 10.1016/j.isci.2024.109677
Xiaoyu Fang, Jinyan Zhang, Xiang Dong, Yuling Zhan, Li Zhang, Chuanmiao Liu, Yu Gao
{"title":"Exploring the effect of SNX16 on sepsis using bioinformatics and a cecum ligation and puncture (CLP) mouse model","authors":"Xiaoyu Fang, Jinyan Zhang, Xiang Dong, Yuling Zhan, Li Zhang, Chuanmiao Liu, Yu Gao","doi":"10.1016/j.isci.2024.109677","DOIUrl":"https://doi.org/10.1016/j.isci.2024.109677","url":null,"abstract":"","PeriodicalId":508122,"journal":{"name":"iScience","volume":"62 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140785896","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mycobacterial CpsA activates type I IFN signaling in macrophages via cGAS-mediated pathway 分枝杆菌 CpsA 通过 cGAS 介导的途径激活巨噬细胞中的 I 型 IFN 信号传导
iScience
Pub Date : 2024-04-01 DOI: 10.1016/j.isci.2024.109807
Yue Ding, Jingfeng Tong, Geyang Luo, Rongfeng Sun, Cheng Bei, Zhihua Feng, Lu Meng, Fei Wang, Jing Zhou, Zihan Chen, Duoduo Li, Yufeng Fan, Shu Song, Decheng Wang, Carl G. Feng, Haipeng Liu, Qi Chen, Bo Yan, Qian Gao
{"title":"Mycobacterial CpsA activates type I IFN signaling in macrophages via cGAS-mediated pathway","authors":"Yue Ding, Jingfeng Tong, Geyang Luo, Rongfeng Sun, Cheng Bei, Zhihua Feng, Lu Meng, Fei Wang, Jing Zhou, Zihan Chen, Duoduo Li, Yufeng Fan, Shu Song, Decheng Wang, Carl G. Feng, Haipeng Liu, Qi Chen, Bo Yan, Qian Gao","doi":"10.1016/j.isci.2024.109807","DOIUrl":"https://doi.org/10.1016/j.isci.2024.109807","url":null,"abstract":"","PeriodicalId":508122,"journal":{"name":"iScience","volume":"28 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140772649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
ALK inhibitors suppress HCC and synergize with anti-PD-1 therapy and ABT-263 in preclinical models 在临床前模型中，ALK抑制剂可抑制HCC并与抗PD-1疗法和ABT-263协同作用
iScience
Pub Date : 2024-04-01 DOI: 10.1016/j.isci.2024.109800
S. Bugide, Dhana Sekhar Reddy, P. Malvi, Romi Gupta, N. Wajapeyee
{"title":"ALK inhibitors suppress HCC and synergize with anti-PD-1 therapy and ABT-263 in preclinical models","authors":"S. Bugide, Dhana Sekhar Reddy, P. Malvi, Romi Gupta, N. Wajapeyee","doi":"10.1016/j.isci.2024.109800","DOIUrl":"https://doi.org/10.1016/j.isci.2024.109800","url":null,"abstract":"","PeriodicalId":508122,"journal":{"name":"iScience","volume":"669 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140784760","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Increased innate immune responses in adolescents with obesity and its relation to subclinical cardiovascular measures: an exploratory study 肥胖症青少年先天性免疫反应的增加及其与亚临床心血管指标的关系：一项探索性研究
iScience
Pub Date : 2024-04-01 DOI: 10.1016/j.isci.2024.109762
S. Bekkering, C. Saner, Boris Novakovic, T. Mansell, Danielle K. Longmore, Z. Mccallum, A. Ponsonby, M. Juonala, M. Netea, M. Sabin, Richard Saffery, N. P. Riksen, David P Burgner
{"title":"Increased innate immune responses in adolescents with obesity and its relation to subclinical cardiovascular measures: an exploratory study","authors":"S. Bekkering, C. Saner, Boris Novakovic, T. Mansell, Danielle K. Longmore, Z. Mccallum, A. Ponsonby, M. Juonala, M. Netea, M. Sabin, Richard Saffery, N. P. Riksen, David P Burgner","doi":"10.1016/j.isci.2024.109762","DOIUrl":"https://doi.org/10.1016/j.isci.2024.109762","url":null,"abstract":"","PeriodicalId":508122,"journal":{"name":"iScience","volume":"28 9","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140771780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Application of Large Language Models in Medicine: A Scoping Review 大型语言模型在医学中的应用：范围综述
iScience
Pub Date : 2024-04-01 DOI: 10.1016/j.isci.2024.109713
X. Meng, Xiangyu Yan, Kuo Zhang, Da Liu, Xiaojuan Cui, Yaodong Yang, Muhan Zhang, Chunxia Cao, Jingjia Wang, Xuliang Wang, Jun gao, Yuan-geng-shuo Wang, Jia-ming Ji, Zifeng Qiu, Muzi Li, Cheng Qian, Tianze Guo, Shuangquan Ma, Zeying Wang, Zexuan Guo, Youlan Lei, Chunli Shao, Wenyao Wang, Haojun Fan, Yifang Tang
{"title":"The Application of Large Language Models in Medicine: A Scoping Review","authors":"X. Meng, Xiangyu Yan, Kuo Zhang, Da Liu, Xiaojuan Cui, Yaodong Yang, Muhan Zhang, Chunxia Cao, Jingjia Wang, Xuliang Wang, Jun gao, Yuan-geng-shuo Wang, Jia-ming Ji, Zifeng Qiu, Muzi Li, Cheng Qian, Tianze Guo, Shuangquan Ma, Zeying Wang, Zexuan Guo, Youlan Lei, Chunli Shao, Wenyao Wang, Haojun Fan, Yifang Tang","doi":"10.1016/j.isci.2024.109713","DOIUrl":"https://doi.org/10.1016/j.isci.2024.109713","url":null,"abstract":"","PeriodicalId":508122,"journal":{"name":"iScience","volume":"156 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140781534","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Fast and High Precision Multi-Robot Environment Modeling Based on M-BFSI: Bidirectional Filtering and Scene Identification Method 基于 M-BFSI：双向过滤和场景识别方法的快速、高精度多机器人环境建模
iScience
Pub Date : 2024-04-01 DOI: 10.1016/j.isci.2024.109721
Dai-ming Liu, Jia-shan Cui, Yong-jian Zhong, Chang-wan Min, Fang-rui Zhang, Dong-zhu Feng
{"title":"A Fast and High Precision Multi-Robot Environment Modeling Based on M-BFSI: Bidirectional Filtering and Scene Identification Method","authors":"Dai-ming Liu, Jia-shan Cui, Yong-jian Zhong, Chang-wan Min, Fang-rui Zhang, Dong-zhu Feng","doi":"10.1016/j.isci.2024.109721","DOIUrl":"https://doi.org/10.1016/j.isci.2024.109721","url":null,"abstract":"","PeriodicalId":508122,"journal":{"name":"iScience","volume":"249 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140763975","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Molecular maps of synovial cells in inflammatory arthritis using an optimized synovium dissociation protocol 使用优化的滑膜解离方案绘制炎性关节炎滑膜细胞的分子图谱
iScience
Pub Date : 2024-04-01 DOI: 10.1016/j.isci.2024.109707
S. Edalat, Reto Gerber, M. Houtman, Janine Lückgen, Rui Lourenço Teixeira, Maria del Pilar Palacios Cisneros, Tamara Pfanner, T. Kuret, Nadja Ižanc, R. Micheroli, Joaquim Polido-Pereira, Fernando Saraiva, Swathi Lingam, Kristina Burki, B. Burja, Chantal Pauli, Ž. Rotar, M. Tomšič, S. Čučnik, João Eurico Fonseca, O. Distler, Ângelo Calado, V. Romão, C. Ospelt, S. Sodin‐Šemrl, Mark D. Robinson, M. F. Bertoncelj
{"title":"Molecular maps of synovial cells in inflammatory arthritis using an optimized synovium dissociation protocol","authors":"S. Edalat, Reto Gerber, M. Houtman, Janine Lückgen, Rui Lourenço Teixeira, Maria del Pilar Palacios Cisneros, Tamara Pfanner, T. Kuret, Nadja Ižanc, R. Micheroli, Joaquim Polido-Pereira, Fernando Saraiva, Swathi Lingam, Kristina Burki, B. Burja, Chantal Pauli, Ž. Rotar, M. Tomšič, S. Čučnik, João Eurico Fonseca, O. Distler, Ângelo Calado, V. Romão, C. Ospelt, S. Sodin‐Šemrl, Mark D. Robinson, M. F. Bertoncelj","doi":"10.1016/j.isci.2024.109707","DOIUrl":"https://doi.org/10.1016/j.isci.2024.109707","url":null,"abstract":"","PeriodicalId":508122,"journal":{"name":"iScience","volume":"468 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140784887","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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