Pub Date : 2023-12-30DOI: 10.20885/jkki.vol14.iss3.art14
Novianti Lailiah, Nursalam, Retno Indarwati
People living with HIV (PLWH) experience higher psychological distress than the general population. Interventions to improve PLWH’s psychological condition need to be adjusted to the their age as each age group’s cognitive abilities are different. This systematic review aims to demonstrate age group-based interventions to improve psychological outcomes in PLWH. A search on articles (2014-2022) focused on experimental studies was conducted on Scopus, SAGE Journal, Science Direct, and PubMed. The searched articles tested interventions to improve psychological outcomes in PLWH and were published in English. The Joanna Briggs Institute (JBI) guidelines were used to assess their eligibility, and PRISMA diagram was used to compile the results of the search. Fifteen studies that matched the inclusion criteria were obtained, and they had experimental study designs. Several types of interventions were identified from the obtained literature. These interventions were designed according to their research subjects, and had been proven to have a significant effect on improving psychosocial conditions and quality of life in PLWH. Further research about age group-based interventions to improve psychological outcomes in PLWH is necessarily suggested. Future research is expected to be able to design interventions that focus on building resilience in individuals. The resilience is to make individuals manage their stress optimally. This may improve not only their psychosocial status but also their adherence to treatment and quality of life.
{"title":"Age group-based interventions to improve psychological outcomes in people living with HIV: A systematic review","authors":"Novianti Lailiah, Nursalam, Retno Indarwati","doi":"10.20885/jkki.vol14.iss3.art14","DOIUrl":"https://doi.org/10.20885/jkki.vol14.iss3.art14","url":null,"abstract":"People living with HIV (PLWH) experience higher psychological distress than the general population. Interventions to improve PLWH’s psychological condition need to be adjusted to the their age as each age group’s cognitive abilities are different. This systematic review aims to demonstrate age group-based interventions to improve psychological outcomes in PLWH. A search on articles (2014-2022) focused on experimental studies was conducted on Scopus, SAGE Journal, Science Direct, and PubMed. The searched articles tested interventions to improve psychological outcomes in PLWH and were published in English. The Joanna Briggs Institute (JBI) guidelines were used to assess their eligibility, and PRISMA diagram was used to compile the results of the search. Fifteen studies that matched the inclusion criteria were obtained, and they had experimental study designs. Several types of interventions were identified from the obtained literature. These interventions were designed according to their research subjects, and had been proven to have a significant effect on improving psychosocial conditions and quality of life in PLWH. Further research about age group-based interventions to improve psychological outcomes in PLWH is necessarily suggested. Future research is expected to be able to design interventions that focus on building resilience in individuals. The resilience is to make individuals manage their stress optimally. This may improve not only their psychosocial status but also their adherence to treatment and quality of life.","PeriodicalId":508182,"journal":{"name":"Jurnal Kedokteran dan Kesehatan Indonesia","volume":" 30","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139138886","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-12-30DOI: 10.20885/jkki.vol14.iss3.art9
Gusti Ayu Putu Ratna Wati, A. Lestarini, S. A. Aryastuti, P. A. Permatananda, P. N. Cahyawati
Background: Diabetic Nephropathy (DN) is the most common complication of diabetes mellitus. Interleukin 6 (IL-6) known as pro-inflammatory cytokine increases extracellular matrix expression and proliferation in DN progression. One single nucleotide polymorphism (SNP) of the Interleukin (IL)-6 gene, rs1800796 play a role in the progression of DN among Asian. Objective: This research seeks to investigate the correlation between IL-6 gene polymorphism (rs1800796) and diabetic nephropathy in individuals diagnosed with type 2 diabetes mellitus (T2DM) among the Balinese population.Methods: This research employed an observational approach through a case-control design involving a total of 60 subjects for each group selected by a simple random sampling method. The occurrence of the rs1800796 polymorphism was identified through polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). The genotype and allele distribution acquired in this study were assessed using the chi-square (χ2) test and Hardy-Weinberg equilibrium law.Results: There were no significant differences identified in the occurrence of (DN) based on the genotype or allele distribution of the IL-6 gene rs1800796. Genotype CG-GG had a higher risk of becoming DN with Odd ratio 1.230, but not statistically significant (p=0.577). Allele G with OR 1.198 (p=0.502) was not significant in causing DN. Conclusion: No significant association was identified between IL-6 polymorphism (rs1800796) and diabetic nephropathy in Balinese individuals with type 2 diabetes mellitus. The lack of association could be due to the presence of other haplotypic connections or might require a larger sample size for conclusive results.
{"title":"Interleukin-6 gene polymorphism (rs1800796) in patient with diabetic nephropathy among Balinese","authors":"Gusti Ayu Putu Ratna Wati, A. Lestarini, S. A. Aryastuti, P. A. Permatananda, P. N. Cahyawati","doi":"10.20885/jkki.vol14.iss3.art9","DOIUrl":"https://doi.org/10.20885/jkki.vol14.iss3.art9","url":null,"abstract":"Background: Diabetic Nephropathy (DN) is the most common complication of diabetes mellitus. Interleukin 6 (IL-6) known as pro-inflammatory cytokine increases extracellular matrix expression and proliferation in DN progression. One single nucleotide polymorphism (SNP) of the Interleukin (IL)-6 gene, rs1800796 play a role in the progression of DN among Asian. Objective: This research seeks to investigate the correlation between IL-6 gene polymorphism (rs1800796) and diabetic nephropathy in individuals diagnosed with type 2 diabetes mellitus (T2DM) among the Balinese population.Methods: This research employed an observational approach through a case-control design involving a total of 60 subjects for each group selected by a simple random sampling method. The occurrence of the rs1800796 polymorphism was identified through polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). The genotype and allele distribution acquired in this study were assessed using the chi-square (χ2) test and Hardy-Weinberg equilibrium law.Results: There were no significant differences identified in the occurrence of (DN) based on the genotype or allele distribution of the IL-6 gene rs1800796. Genotype CG-GG had a higher risk of becoming DN with Odd ratio 1.230, but not statistically significant (p=0.577). Allele G with OR 1.198 (p=0.502) was not significant in causing DN. Conclusion: No significant association was identified between IL-6 polymorphism (rs1800796) and diabetic nephropathy in Balinese individuals with type 2 diabetes mellitus. The lack of association could be due to the presence of other haplotypic connections or might require a larger sample size for conclusive results.","PeriodicalId":508182,"journal":{"name":"Jurnal Kedokteran dan Kesehatan Indonesia","volume":" 11","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139140183","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-12-30DOI: 10.20885/jkki.vol14.iss3.art4
Suryo Wibowo, Endang Sri Lestari, Muhammad Thohar Arifin, Yan Wisnu Prajoko, N. Susilaningsih
Background: The wound healing process consists of three phases, namely inflammation, proliferation, and remodeling. Many cells and mediators are involved in this process, including platelets and transforming growth factor-β (TGF-β). Methicillin-resistant Staphylococcus aureus (MRSA) is a bacterial strain resistant to beta-lactam antibiotics. Clove flower (Syzygium aromaticum) is an herb with properties to promote wound healingObjective: To determine the effect of clove flower extract on increasing epithelialization of incision wounds, platelet counts, and TGF-β levels in mice infected with MRSAMethods: A randomized experimental study on 30 male wistar rats (Rattus norvegicus) infected with MRSA. All rats were randomly divided into six groups; healthy control, positive control induced by MRSA and Vancomycin 9 mg/200 gram body weight (gbw), negative control MRSA with normal saline, and administration of clove flower extract (CFE) 25 mg/200 gbw, CFE 50 mg/200 gbw, and CFE 100 mg/200 gbw. Examination of the sectioned wound epithelium was performed histologically using Hematoxylin-Eosin (HE), while platelet count and TGF-β levels were measured using an ELISA RAB0479 kit simultaneously on the 21st day. Results: Histological examination of rats treated with CFE 100 mg/200 gbw and uninfected rats showed complete epithelization. Platelet counts and TGF-β levels were significantly higher in rats administered CFE 100 mg/200 gbw (p<0.001) compared to the other five groups. Conclusion: Administrating CFE increased incision wound epithelialization, platelet count, and TGF-β levels in MRSA-infected rats.
{"title":"Clove flower extracts (Syzgium aromaticum) increased incision wound epithelization, platelet count, and TGF-β levels in methicillin-resistant Staphylococcus aureus-infected rats","authors":"Suryo Wibowo, Endang Sri Lestari, Muhammad Thohar Arifin, Yan Wisnu Prajoko, N. Susilaningsih","doi":"10.20885/jkki.vol14.iss3.art4","DOIUrl":"https://doi.org/10.20885/jkki.vol14.iss3.art4","url":null,"abstract":"Background: The wound healing process consists of three phases, namely inflammation, proliferation, and remodeling. Many cells and mediators are involved in this process, including platelets and transforming growth factor-β (TGF-β). Methicillin-resistant Staphylococcus aureus (MRSA) is a bacterial strain resistant to beta-lactam antibiotics. Clove flower (Syzygium aromaticum) is an herb with properties to promote wound healingObjective: To determine the effect of clove flower extract on increasing epithelialization of incision wounds, platelet counts, and TGF-β levels in mice infected with MRSAMethods: A randomized experimental study on 30 male wistar rats (Rattus norvegicus) infected with MRSA. All rats were randomly divided into six groups; healthy control, positive control induced by MRSA and Vancomycin 9 mg/200 gram body weight (gbw), negative control MRSA with normal saline, and administration of clove flower extract (CFE) 25 mg/200 gbw, CFE 50 mg/200 gbw, and CFE 100 mg/200 gbw. Examination of the sectioned wound epithelium was performed histologically using Hematoxylin-Eosin (HE), while platelet count and TGF-β levels were measured using an ELISA RAB0479 kit simultaneously on the 21st day. Results: Histological examination of rats treated with CFE 100 mg/200 gbw and uninfected rats showed complete epithelization. Platelet counts and TGF-β levels were significantly higher in rats administered CFE 100 mg/200 gbw (p<0.001) compared to the other five groups. Conclusion: Administrating CFE increased incision wound epithelialization, platelet count, and TGF-β levels in MRSA-infected rats.","PeriodicalId":508182,"journal":{"name":"Jurnal Kedokteran dan Kesehatan Indonesia","volume":" 16","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139141624","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-12-30DOI: 10.20885/jkki.vol14.iss3.art8
Almira Fadhila Az Zahra, Yuswo Supatmo, Muhammad Reza Wijoko Ekaputera
Background: Pilates is a kind of exercise that incorporates both physical and mental components in its practice. Transcendental meditation comprises a collection of approaches that center on attention and awareness cultivation. Upon reaching adulthood, a person must possess a significant level of cognitive ability to guarantee optimal production. Pilates and transcendental meditation have emerged as potential options for enhancing cognitive processes, especially short-term memory. Objective: This study aims to investigate the impact of Pilates exercise, both alone and in conjunction with transcendental meditation, on short-term memory.Methods: The present study used an experimental design including three parallel groups and performed a pre-test and post-test design. The participants in this study consisted of 45 adult females ranging in age from 25 to 55 years. They were selected using the purposive sampling method and were divided into three groups based on the interventions received. The first group received a combination of Pilates exercise and transcendental meditation (n=15), the second group received Pilates exercise alone (n=15), and the third group served as the control group (n=15). Both intervention groups participated in 16 sessions, which were performed three times per week over six weeks. The Scenery Picture Memory Test (SPMT) was used to assess short-term memory. The data analyses were done using the paired t-test and One-way ANOVA. Results: Significant improvements (p<0.05) in SPMT scores were found across all groups after their respective therapies. There were stark differences in the results of the SPMT between the group engaged in Pilates exercise and the group practicing transcendental meditation (p=0.001), as well as between the Pilates exercise group and the control group (p<0.001). Besides, a significant result was found between the Pilates exercise group and the control group (p=0.01).Conclusion: The Pilates exercise, whether performed alone or in conjunction with transcendental meditation, has been shown to enhance short-term memory. Notably, engaging in Pilates exercise with transcendental meditation has a more pronounced and efficacious outcome.
{"title":"Comparison between Pilates exercise and combination with transcen-dental meditation towards short-term memory among adult females","authors":"Almira Fadhila Az Zahra, Yuswo Supatmo, Muhammad Reza Wijoko Ekaputera","doi":"10.20885/jkki.vol14.iss3.art8","DOIUrl":"https://doi.org/10.20885/jkki.vol14.iss3.art8","url":null,"abstract":"Background: Pilates is a kind of exercise that incorporates both physical and mental components in its practice. Transcendental meditation comprises a collection of approaches that center on attention and awareness cultivation. Upon reaching adulthood, a person must possess a significant level of cognitive ability to guarantee optimal production. Pilates and transcendental meditation have emerged as potential options for enhancing cognitive processes, especially short-term memory. Objective: This study aims to investigate the impact of Pilates exercise, both alone and in conjunction with transcendental meditation, on short-term memory.Methods: The present study used an experimental design including three parallel groups and performed a pre-test and post-test design. The participants in this study consisted of 45 adult females ranging in age from 25 to 55 years. They were selected using the purposive sampling method and were divided into three groups based on the interventions received. The first group received a combination of Pilates exercise and transcendental meditation (n=15), the second group received Pilates exercise alone (n=15), and the third group served as the control group (n=15). Both intervention groups participated in 16 sessions, which were performed three times per week over six weeks. The Scenery Picture Memory Test (SPMT) was used to assess short-term memory. The data analyses were done using the paired t-test and One-way ANOVA. Results: Significant improvements (p<0.05) in SPMT scores were found across all groups after their respective therapies. There were stark differences in the results of the SPMT between the group engaged in Pilates exercise and the group practicing transcendental meditation (p=0.001), as well as between the Pilates exercise group and the control group (p<0.001). Besides, a significant result was found between the Pilates exercise group and the control group (p=0.01).Conclusion: The Pilates exercise, whether performed alone or in conjunction with transcendental meditation, has been shown to enhance short-term memory. Notably, engaging in Pilates exercise with transcendental meditation has a more pronounced and efficacious outcome.","PeriodicalId":508182,"journal":{"name":"Jurnal Kedokteran dan Kesehatan Indonesia","volume":" 16","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139137149","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-12-30DOI: 10.20885/jkki.vol14.iss3.art16
Triasari Oktavriana, Bobby Febrianto, Ihsan Hanif, Azhar Arrosyid, Lian Kamilah, Fanny Fauziyyah Heryadi, Harijono Kariosentono
Maculopapular drug eruption (MDE) is the most typical type of hypersensitivity reaction. Patients with human immunodeficiency virus (HIV) infection may develop some complications, including wasting syndrome, contributing to immune system dysregulation. The late stage of HIV infection increases the risk of pulmonary tuberculosis (TB), in which the administration of anti-tuberculosis drugs (ATD) often induces drug eruptions. A 41-year-old man complained of itchy skin rash on his hands, body, and feet. The rash appeared after a streptomycin injection on the 9th day, accompanied by complaints of fever, weakness, dizziness, and chronic cough followed by fever at night. The patient was treated and diagnosed with a new case of pulmonary TB; and he also received first-line ATD. The streptomycin injection was given because systemic manifestation still appeared. The researchers diagnosed the patient with HIV infection with wasting syndrome. He was hospitalized and given methylprednisolone injection, paracetamol infusion, omeprazole injection, oral cetirizine, and moisturizer. After that, clinical improvement occurred, and he was discharged on the fourth day. Patients with HIV infection often develop MDE. Clinical manifestations of maculopapular drug eruption are generally mild without systemic complaints; however, in certain conditions, such as HIV infection with wasting syndrome, more severe systemic symptoms can appear due to excess secretion of several proinflammatory cytokines. Several studies have also reported an increased incidence of maculopapular drug eruption caused by first-line anti-HIV drugs, especially in patients with HIV infection.
{"title":"Maculopapular drug eruption in a patient with human immunodeficiency virus (HIV) infection, wasting syndrome and pulmonary tuberculosis: A case report","authors":"Triasari Oktavriana, Bobby Febrianto, Ihsan Hanif, Azhar Arrosyid, Lian Kamilah, Fanny Fauziyyah Heryadi, Harijono Kariosentono","doi":"10.20885/jkki.vol14.iss3.art16","DOIUrl":"https://doi.org/10.20885/jkki.vol14.iss3.art16","url":null,"abstract":"Maculopapular drug eruption (MDE) is the most typical type of hypersensitivity reaction. Patients with human immunodeficiency virus (HIV) infection may develop some complications, including wasting syndrome, contributing to immune system dysregulation. The late stage of HIV infection increases the risk of pulmonary tuberculosis (TB), in which the administration of anti-tuberculosis drugs (ATD) often induces drug eruptions. A 41-year-old man complained of itchy skin rash on his hands, body, and feet. The rash appeared after a streptomycin injection on the 9th day, accompanied by complaints of fever, weakness, dizziness, and chronic cough followed by fever at night. The patient was treated and diagnosed with a new case of pulmonary TB; and he also received first-line ATD. The streptomycin injection was given because systemic manifestation still appeared. The researchers diagnosed the patient with HIV infection with wasting syndrome. He was hospitalized and given methylprednisolone injection, paracetamol infusion, omeprazole injection, oral cetirizine, and moisturizer. After that, clinical improvement occurred, and he was discharged on the fourth day. Patients with HIV infection often develop MDE. Clinical manifestations of maculopapular drug eruption are generally mild without systemic complaints; however, in certain conditions, such as HIV infection with wasting syndrome, more severe systemic symptoms can appear due to excess secretion of several proinflammatory cytokines. Several studies have also reported an increased incidence of maculopapular drug eruption caused by first-line anti-HIV drugs, especially in patients with HIV infection.","PeriodicalId":508182,"journal":{"name":"Jurnal Kedokteran dan Kesehatan Indonesia","volume":" 11","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139138795","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-12-30DOI: 10.20885/jkki.vol14.iss3.art15
Putri Mirani, P. M. Lestari, K. Murti, I. A. Liberty, Hana Andrina, C. Kesty, Bella Stevanny
Placenta accreta spectrum disorder (PASD) refers to a range of pathological placental adhesions to the uterine wall, previously classified into three subtypes: placenta accreta, placenta increta, and placenta percreta, based on the invasiveness of the villous tissue. This article provides an updated review of the literature on PASD with new insights into the etiopathology of PASD. Recent evidence suggests that extravillous trophoblasts are not overly invasive and that accreta placentation is more likely due to decidualisation failure resulting from blastocyst implantation within a caesarean scar defect (CSD). Previous caesarean delivery has been the most well-known risk factor of PASD, with the increased occurrence of PASD along with the increased number of previous caesarean deliveries. Antenatal identification of PASD is strongly recommended to improve outcomes before the onset of labour or bleeding, so that placental abruption can be avoided. Ultrasonography can identify PASD in the first trimester with good sensitivity and specificity. A standardised approach with a comprehensive multidisciplinary care team is required to manage PASD effectively. The Royal College of Obstetricians and Gynaecologists (RCOG), along with The American College of Obstetricians and Gynaecologists (ACOG), have published guidelines for the best clinical management of PASD. Future research should concentrate on gathering prospective data on the diagnosis and management of PASD in order to assess the association between prenatal imaging, clinical grading, and histology findings. This will lead to more accurate PASD screening, reliable diagnostic criteria, and alternatives to prenatal treatment.
{"title":"Placenta accreta spectrum disorder: An updated literature review","authors":"Putri Mirani, P. M. Lestari, K. Murti, I. A. Liberty, Hana Andrina, C. Kesty, Bella Stevanny","doi":"10.20885/jkki.vol14.iss3.art15","DOIUrl":"https://doi.org/10.20885/jkki.vol14.iss3.art15","url":null,"abstract":"Placenta accreta spectrum disorder (PASD) refers to a range of pathological placental adhesions to the uterine wall, previously classified into three subtypes: placenta accreta, placenta increta, and placenta percreta, based on the invasiveness of the villous tissue. This article provides an updated review of the literature on PASD with new insights into the etiopathology of PASD. Recent evidence suggests that extravillous trophoblasts are not overly invasive and that accreta placentation is more likely due to decidualisation failure resulting from blastocyst implantation within a caesarean scar defect (CSD). Previous caesarean delivery has been the most well-known risk factor of PASD, with the increased occurrence of PASD along with the increased number of previous caesarean deliveries. Antenatal identification of PASD is strongly recommended to improve outcomes before the onset of labour or bleeding, so that placental abruption can be avoided. Ultrasonography can identify PASD in the first trimester with good sensitivity and specificity. A standardised approach with a comprehensive multidisciplinary care team is required to manage PASD effectively. The Royal College of Obstetricians and Gynaecologists (RCOG), along with The American College of Obstetricians and Gynaecologists (ACOG), have published guidelines for the best clinical management of PASD. Future research should concentrate on gathering prospective data on the diagnosis and management of PASD in order to assess the association between prenatal imaging, clinical grading, and histology findings. This will lead to more accurate PASD screening, reliable diagnostic criteria, and alternatives to prenatal treatment.","PeriodicalId":508182,"journal":{"name":"Jurnal Kedokteran dan Kesehatan Indonesia","volume":" 34","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139139119","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-12-30DOI: 10.20885/jkki.vol14.iss3.art11
Fairuz Fairuz, Humaryanto Humaryanto
Background: Phyllodes tumors and fibroadenomas are groups of fibroepithelial tumors in the breast that have different therapeutic approaches due to their rate of progression. The observed phenomenon can be attributed to the proclivity for recurrence and shared histologic characteristics, particularly within the fibroadenoma (FAs), benign phyllodes and borderline phyllodes. It's pathomechanism is undetermined yet. Human telomerase reverse transcriptase (hTERT) is one of the genes thought to play a role in the pathomechanism of this tumor.Objective: This study aimed to determine the comparison of hTERT immunoexpression in the most common fibroepithelial tumor types.Methods: This research was an analytic observational study with cross sectional method. The samples used were FAs and phyllodes tumors (PTs) which were divided according to the 2019 World Health Organization (WHO) classification. Histopathological examination was conducted on paraffin-embedded tissue blocks with FAs and PTs. Staining was performed using immunohistochemistry techniques with hTERT antibodies. Results: A total of 69 samples were obtained consisting of 26 FAs, 17 benign PTs, 16 borderline PTs, and 10 malignant PTs. A significant difference was found in the loss of hTERT expression in fibroadenoma and phyllodes tumors in various grades. There was a positive correlation between hTERT immunoexpression and tumor type in this study (p= 0.0001). Conclusion: There were significant changes in hTERT immunoexpression in fibroepithelial tumors, suggesting a role for hTERT in the pathomechanism of breast fibroepithelial tumors can be considered.
{"title":"Immunoexpression of human telomerase reverse transcriptase in fibroepithelial tumors of the breast","authors":"Fairuz Fairuz, Humaryanto Humaryanto","doi":"10.20885/jkki.vol14.iss3.art11","DOIUrl":"https://doi.org/10.20885/jkki.vol14.iss3.art11","url":null,"abstract":"Background: Phyllodes tumors and fibroadenomas are groups of fibroepithelial tumors in the breast that have different therapeutic approaches due to their rate of progression. The observed phenomenon can be attributed to the proclivity for recurrence and shared histologic characteristics, particularly within the fibroadenoma (FAs), benign phyllodes and borderline phyllodes. It's pathomechanism is undetermined yet. Human telomerase reverse transcriptase (hTERT) is one of the genes thought to play a role in the pathomechanism of this tumor.Objective: This study aimed to determine the comparison of hTERT immunoexpression in the most common fibroepithelial tumor types.Methods: This research was an analytic observational study with cross sectional method. The samples used were FAs and phyllodes tumors (PTs) which were divided according to the 2019 World Health Organization (WHO) classification. Histopathological examination was conducted on paraffin-embedded tissue blocks with FAs and PTs. Staining was performed using immunohistochemistry techniques with hTERT antibodies. Results: A total of 69 samples were obtained consisting of 26 FAs, 17 benign PTs, 16 borderline PTs, and 10 malignant PTs. A significant difference was found in the loss of hTERT expression in fibroadenoma and phyllodes tumors in various grades. There was a positive correlation between hTERT immunoexpression and tumor type in this study (p= 0.0001). Conclusion: There were significant changes in hTERT immunoexpression in fibroepithelial tumors, suggesting a role for hTERT in the pathomechanism of breast fibroepithelial tumors can be considered.","PeriodicalId":508182,"journal":{"name":"Jurnal Kedokteran dan Kesehatan Indonesia","volume":" 102","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139139269","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mesenchymal prostate tumours are relatively rare compared to epithelial tumours. To diagnose mesenchymal tumours on transurethral resection of the prostate (TURP) specimen, doctors have to consider a few differential diagnoses, including gastrointestinal stromal tumour (GISTs). We reported a 63 years-old male patient, presented with urinary retention in one week. Based on an initial scan of the abdomen, a large lobulated mass in the pelvic cavity from the prostate pushed up the urinary bladder. Histopathologic examination demonstrated cellular spindle cell neoplastic proliferation, a moderate degree of atypia, and a mitotic count of >5 per 50 high-power fields (HPFs) with a fascicular growth pattern. Immunohistochemically, the tumour had positive expression for CD117 (c-KIT), CD34, and discovered on Gist-1 (DOG-1), while smooth muscle actin (SMA) and S-100 were negative. The pathological report was consistent with a high-risk group of GISTs in the prostate. Subsequent imaging revealed that the tumour mass was centrally located between the rectum and prostate, infiltrating bladder and liver metastases. Comprehensive differential diagnoses of mesenchymal tumours involving the prostate are necessary because of the inadequacy of specific clinical signs, symptoms, and unexpected location. Diagnoses of GISTs was performed based on spindle cell pattern and the positive immunohistochemistry expression for CD117, CD34, and DOG-1. The tumour mass involved in the prostate with spindled morphology should be considered as a GIST, assisted with appropriate immunohistochemistry marker panel. It is a challenge to diagnose the GIST particularly involving the prostate.
{"title":"Diagnostic challenges of gastrointestinal stromal tumour during transurethral resection of the prostate: A case report","authors":"Anandia Putriyuni, Yevri Zulfiqar, Santy Saberko, Lila Indrati","doi":"10.20885/jkki.vol14.iss3.art17","DOIUrl":"https://doi.org/10.20885/jkki.vol14.iss3.art17","url":null,"abstract":"Mesenchymal prostate tumours are relatively rare compared to epithelial tumours. To diagnose mesenchymal tumours on transurethral resection of the prostate (TURP) specimen, doctors have to consider a few differential diagnoses, including gastrointestinal stromal tumour (GISTs). We reported a 63 years-old male patient, presented with urinary retention in one week. Based on an initial scan of the abdomen, a large lobulated mass in the pelvic cavity from the prostate pushed up the urinary bladder. Histopathologic examination demonstrated cellular spindle cell neoplastic proliferation, a moderate degree of atypia, and a mitotic count of >5 per 50 high-power fields (HPFs) with a fascicular growth pattern. Immunohistochemically, the tumour had positive expression for CD117 (c-KIT), CD34, and discovered on Gist-1 (DOG-1), while smooth muscle actin (SMA) and S-100 were negative. The pathological report was consistent with a high-risk group of GISTs in the prostate. Subsequent imaging revealed that the tumour mass was centrally located between the rectum and prostate, infiltrating bladder and liver metastases. Comprehensive differential diagnoses of mesenchymal tumours involving the prostate are necessary because of the inadequacy of specific clinical signs, symptoms, and unexpected location. Diagnoses of GISTs was performed based on spindle cell pattern and the positive immunohistochemistry expression for CD117, CD34, and DOG-1. The tumour mass involved in the prostate with spindled morphology should be considered as a GIST, assisted with appropriate immunohistochemistry marker panel. It is a challenge to diagnose the GIST particularly involving the prostate.","PeriodicalId":508182,"journal":{"name":"Jurnal Kedokteran dan Kesehatan Indonesia","volume":" 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139141246","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-12-30DOI: 10.20885/jkki.vol14.iss3.art12
Ika Alifa Suryabrata, W. Ardini, Sity Kunarisasi
Background: Malnutrition, especially overnutrition, is a primary adult nutrition problem. Food intake and physical activity have been the primary factors that affect nutritional status. In college students, food consumption and physical activity tend not to be compatible with the recommendation. Objective: To know the association between nutrient intake and physical activity with the nutritional status of undergraduate students in the Faculty of Medicine of the Universitas Islam Negeri (UIN) Syarif Hidayatullah Jakarta.Methods: This study was an analytical cross-sectional at the Faculty of Medicine, UIN Syarif Hidayatullah Jakarta, from August to September 2019. The sample of this study was undergraduate medical students at the Faculty of Medicine UIN Syarif Hidayatullah Jakarta, with as many as 113 students meeting qualified criteria. The sample was chosen with a stratified sampling method. Data was taken using IPAQ (International Physical Activity Questionnaire) for physical activity, food records, and height and body weight measurements. Data was analysed using comparative analysis Results: Our analysis demonstrated an association between nutritional status and adequacy of calorie intake (p = 0.001), as well as macronutrient intake (p = 0.001). There was no association between nutritional status and physical activity (p = 0.737). Conclusion: There was an association between nutrient intake and the nutritional status of undergraduate medical students in the Faculty of Medicine UIN Syarif Hidayatullah Jakarta. On the contrary, there was no association between physical activity and the nutritional status of undergraduate medical students in the Faculty of Medicine UIN Syarif Hidayatullah Jakarta.
{"title":"The association between nutrient intake and physical activity with nutritional status of undergraduate medical students","authors":"Ika Alifa Suryabrata, W. Ardini, Sity Kunarisasi","doi":"10.20885/jkki.vol14.iss3.art12","DOIUrl":"https://doi.org/10.20885/jkki.vol14.iss3.art12","url":null,"abstract":"Background: Malnutrition, especially overnutrition, is a primary adult nutrition problem. Food intake and physical activity have been the primary factors that affect nutritional status. In college students, food consumption and physical activity tend not to be compatible with the recommendation. Objective: To know the association between nutrient intake and physical activity with the nutritional status of undergraduate students in the Faculty of Medicine of the Universitas Islam Negeri (UIN) Syarif Hidayatullah Jakarta.Methods: This study was an analytical cross-sectional at the Faculty of Medicine, UIN Syarif Hidayatullah Jakarta, from August to September 2019. The sample of this study was undergraduate medical students at the Faculty of Medicine UIN Syarif Hidayatullah Jakarta, with as many as 113 students meeting qualified criteria. The sample was chosen with a stratified sampling method. Data was taken using IPAQ (International Physical Activity Questionnaire) for physical activity, food records, and height and body weight measurements. Data was analysed using comparative analysis Results: Our analysis demonstrated an association between nutritional status and adequacy of calorie intake (p = 0.001), as well as macronutrient intake (p = 0.001). There was no association between nutritional status and physical activity (p = 0.737). Conclusion: There was an association between nutrient intake and the nutritional status of undergraduate medical students in the Faculty of Medicine UIN Syarif Hidayatullah Jakarta. On the contrary, there was no association between physical activity and the nutritional status of undergraduate medical students in the Faculty of Medicine UIN Syarif Hidayatullah Jakarta.","PeriodicalId":508182,"journal":{"name":"Jurnal Kedokteran dan Kesehatan Indonesia","volume":" 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139141447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: The incidence of chronic kidney disease (CKD) continues to increase from year to year. There was an increase in CKD rates in the 2013 and 2018 basic health research or Riset kesehatan dasar (Riskesdas). Several provinces in Indonesia show a high incidence of CKD and require hemodialysis. As the incidence of CKD increases, it is important to investigate the influencing factors.Objective: To identify the influencing factors of CKD incidence in Indonesia.Methods: Data from 11 provinces with the highest incidence of CKD and hemodialysis were obtained from the Indonesian Ministry of Health through the Riskesdas 2018 survey. For comparison, the incidence of hemodialysis patients in 2020 at Immanuel Hospital Bandung was included in the investigation. All data were analysed using a Python software program, and a decision tree was determined. The results of the decision tree were analysed using Chi-square. Subject profiles were descriptively analysed for some Riskesdas 2018 data and medical records at Immanuel Hospital. Results: The total data from Riskesdas was 130,787 subjects, among those, there were 610 people with CKD/hemodialysis, meanwhile data of 79 people with hemodialysis were obtained from Immanuel Hospital. The odds ratios of diabetes mellitus was 4.54 (p=0.000), hypertension was 3.00 (p=0.000), salty food was 2.26 (p=0.000), waist circumference (WC) was 1.35 (p=0.025), and body mass index (BMI) was 1.06 (p=0.605). Conclusion: Diabetes, hypertension, salty foods, WC and BMI are the five most important factors influencing the incidence of CKD in Indonesia. These variables need to be managed properly to reduce the incidence of CKD.
{"title":"Analysis of influencing factors in chronic kidney disease incidence in Indonesia","authors":"Meilinah Hidayat, Fabiola Motulo, Santoso Chandra, Stephanie Andamari, J. Sulungbudi, Ronny Lesmana","doi":"10.20885/jkki.vol14.iss3.art10","DOIUrl":"https://doi.org/10.20885/jkki.vol14.iss3.art10","url":null,"abstract":"Background: The incidence of chronic kidney disease (CKD) continues to increase from year to year. There was an increase in CKD rates in the 2013 and 2018 basic health research or Riset kesehatan dasar (Riskesdas). Several provinces in Indonesia show a high incidence of CKD and require hemodialysis. As the incidence of CKD increases, it is important to investigate the influencing factors.Objective: To identify the influencing factors of CKD incidence in Indonesia.Methods: Data from 11 provinces with the highest incidence of CKD and hemodialysis were obtained from the Indonesian Ministry of Health through the Riskesdas 2018 survey. For comparison, the incidence of hemodialysis patients in 2020 at Immanuel Hospital Bandung was included in the investigation. All data were analysed using a Python software program, and a decision tree was determined. The results of the decision tree were analysed using Chi-square. Subject profiles were descriptively analysed for some Riskesdas 2018 data and medical records at Immanuel Hospital. Results: The total data from Riskesdas was 130,787 subjects, among those, there were 610 people with CKD/hemodialysis, meanwhile data of 79 people with hemodialysis were obtained from Immanuel Hospital. The odds ratios of diabetes mellitus was 4.54 (p=0.000), hypertension was 3.00 (p=0.000), salty food was 2.26 (p=0.000), waist circumference (WC) was 1.35 (p=0.025), and body mass index (BMI) was 1.06 (p=0.605). Conclusion: Diabetes, hypertension, salty foods, WC and BMI are the five most important factors influencing the incidence of CKD in Indonesia. These variables need to be managed properly to reduce the incidence of CKD.","PeriodicalId":508182,"journal":{"name":"Jurnal Kedokteran dan Kesehatan Indonesia","volume":" 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139139850","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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