Pub Date : 2023-12-30DOI: 10.20885/jkki.vol14.iss3.art6
Akbar Zulkifli Osman, Eska Agustin Putri Susanti, R. I. Estiko, Meiza Fadhila Azzahra, A. D. Widyadhana
Background: Chronic kidney disease (CKD) imposes a significant global burden, with diabetes and hypertension being major contributors. In the severe stage, CKD patients require long-term hemodialysis (HD) treatment and rely on family caregivers for support. Caregivers often experience mental health challenges, including anxiety and depression, which can impact their quality of life and patient outcomes.Objective: This study aimed to identify the anxiety and depression incidence in HD family caregivers at Soehadi Prijonegoro Regional Public Hospital (SPRPH), identify the risk factors associated with these conditions, and investigate the relationship between anxiety and depressionMethods: A cross-sectional analysis was carried out at the Hemodialysis Department from November 2022 to February 2023. Caregivers accompanying CKD patients undergoing HD participated voluntarily. Anxiety and depression levels were evaluated using the Hamilton Anxiety Rating Scale (HAM-A) and Hamilton Depression Rating Scale (HAM-D). Results: Out of 106 participants, 66% were female. Most caregivers (99%) experienced anxiety, with 91% classified as mild and 8% as mild to moderate. Depression was reported by 42%, with 2% experiencing mild to moderate symptoms. Spearman’s analysis revealed a significant correlation between anxiety and depression (p=0.000). No specific caregiver characteristics were found to be associated with anxiety or depression.Conclusion: Family caregivers of HD patients demonstrated a high incidence of anxiety and a lower prevalence of depression. Anxiety levels were correlated with depression levels. We did not identify specific risk factors for these mental health conditions among caregivers. These findings emphasize the need for mental health screening and appropriate management to improve the quality of life for HD family caregivers.
{"title":"Anxiety and depression in family caregivers of hemodialysis patients: Incidence, risk factors, and correlation","authors":"Akbar Zulkifli Osman, Eska Agustin Putri Susanti, R. I. Estiko, Meiza Fadhila Azzahra, A. D. Widyadhana","doi":"10.20885/jkki.vol14.iss3.art6","DOIUrl":"https://doi.org/10.20885/jkki.vol14.iss3.art6","url":null,"abstract":"Background: Chronic kidney disease (CKD) imposes a significant global burden, with diabetes and hypertension being major contributors. In the severe stage, CKD patients require long-term hemodialysis (HD) treatment and rely on family caregivers for support. Caregivers often experience mental health challenges, including anxiety and depression, which can impact their quality of life and patient outcomes.Objective: This study aimed to identify the anxiety and depression incidence in HD family caregivers at Soehadi Prijonegoro Regional Public Hospital (SPRPH), identify the risk factors associated with these conditions, and investigate the relationship between anxiety and depressionMethods: A cross-sectional analysis was carried out at the Hemodialysis Department from November 2022 to February 2023. Caregivers accompanying CKD patients undergoing HD participated voluntarily. Anxiety and depression levels were evaluated using the Hamilton Anxiety Rating Scale (HAM-A) and Hamilton Depression Rating Scale (HAM-D). Results: Out of 106 participants, 66% were female. Most caregivers (99%) experienced anxiety, with 91% classified as mild and 8% as mild to moderate. Depression was reported by 42%, with 2% experiencing mild to moderate symptoms. Spearman’s analysis revealed a significant correlation between anxiety and depression (p=0.000). No specific caregiver characteristics were found to be associated with anxiety or depression.Conclusion: Family caregivers of HD patients demonstrated a high incidence of anxiety and a lower prevalence of depression. Anxiety levels were correlated with depression levels. We did not identify specific risk factors for these mental health conditions among caregivers. These findings emphasize the need for mental health screening and appropriate management to improve the quality of life for HD family caregivers.","PeriodicalId":508182,"journal":{"name":"Jurnal Kedokteran dan Kesehatan Indonesia","volume":" 19","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139138442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: Diabetes peripheral neuropathy (DPN) is a set of signs and symptoms of peripheral nervous system dysfunction in diabetes mellitus patients. Abdominal obesity is one of the main risk factors for DPN. Diabetic neuropathy symptom (DNS) is a reliable instrument with consistent results for the diagnosis of neuropathy. Objective: This study aimed to determine the correlation of abdominal obesity with scores. Methods: This research was a quantitative study with a cross-sectional approach. The sample of this study was 92 type 2 diabetes mellitus (T2DM) patients aged range 30-60 years who participated in the chronic disease management program (Prolanis) and the integrated healthcare center (Posbindu) for people in the area of three public health centers (Puskesmas) in Pekalongan Regency which purposively selected. Instruments used to measure DPN were DNS sheets, and abdominal obesity was measured by waist circumference using a midline. The bivariate analysis was performed using the Pearson correlation and linear regression tests. Results: There was a correlation between abdominal obesity and DNS scores with a p value of 0.043 with a correlation coefficient of 0.212. The DNS score was influenced by age, gender, duration of diabetes, and body mass index by 13.4%. Conclusion: There was a correlation between abdominal obesity and DNS scores. It indicated that the higher the value of abdominal obesity was, the higher DNS scores increased.
背景：糖尿病周围神经病变（DPN）是糖尿病患者周围神经系统功能障碍的一系列症状和体征。腹部肥胖是导致 DPN 的主要危险因素之一。糖尿病神经病变症状（DNS）是一种可靠的神经病变诊断工具，其结果具有一致性。研究目的本研究旨在确定腹部肥胖与评分的相关性。研究方法本研究为横断面定量研究。研究样本为 92 名 2 型糖尿病（T2DM）患者，年龄在 30-60 岁之间，他们参加了慢性病管理计划（Prolanis）和综合医疗保健中心（Posbindu），这些医疗保健中心位于北加隆安县（Pekalongan Regency）的三个公共医疗保健中心（Puskesmas）。用于测量 DPN 的工具是 DNS 表，腹部肥胖的测量方法是使用中线测量腰围。使用皮尔逊相关检验和线性回归检验进行双变量分析。结果显示腹部肥胖与 DNS 评分之间存在相关性，相关系数为 0.212，P 值为 0.043。DNS 评分受年龄、性别、糖尿病病程和体重指数的影响为 13.4%。结论腹部肥胖与 DNS 评分之间存在相关性。这表明腹部肥胖值越高，DNS 分数也越高。
{"title":"Analysis of determinant diabetic neuropathy symptom score factors in diabetes mellitus patients","authors":"Nurul Aktifah, Umi Budi Rahayu, Muhammad Ghilang Maulud Setyawan, Firman Faradisi, Dwi Fijianto","doi":"10.20885/jkki.vol14.iss3.art7","DOIUrl":"https://doi.org/10.20885/jkki.vol14.iss3.art7","url":null,"abstract":"Background: Diabetes peripheral neuropathy (DPN) is a set of signs and symptoms of peripheral nervous system dysfunction in diabetes mellitus patients. Abdominal obesity is one of the main risk factors for DPN. Diabetic neuropathy symptom (DNS) is a reliable instrument with consistent results for the diagnosis of neuropathy. Objective: This study aimed to determine the correlation of abdominal obesity with scores. Methods: This research was a quantitative study with a cross-sectional approach. The sample of this study was 92 type 2 diabetes mellitus (T2DM) patients aged range 30-60 years who participated in the chronic disease management program (Prolanis) and the integrated healthcare center (Posbindu) for people in the area of three public health centers (Puskesmas) in Pekalongan Regency which purposively selected. Instruments used to measure DPN were DNS sheets, and abdominal obesity was measured by waist circumference using a midline. The bivariate analysis was performed using the Pearson correlation and linear regression tests. Results: There was a correlation between abdominal obesity and DNS scores with a p value of 0.043 with a correlation coefficient of 0.212. The DNS score was influenced by age, gender, duration of diabetes, and body mass index by 13.4%. Conclusion: There was a correlation between abdominal obesity and DNS scores. It indicated that the higher the value of abdominal obesity was, the higher DNS scores increased.","PeriodicalId":508182,"journal":{"name":"Jurnal Kedokteran dan Kesehatan Indonesia","volume":" 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139137965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-12-30DOI: 10.20885/jkki.vol14.iss3.art13
Azzahra Afifah, Fara Syafira, Dini Dharmawidiarini
The development of smartphones worldwide has rapidly increased the number of smartphone users. Although smartphones have many benefits, prolonged use causes various visual disorders, of which transient smartphone blindness (TSB) is one of the most important concerns. This study aims to analyse the phenomenon of TSB and explore its etiology, pathophysiology, symptoms, and examination to determine the diagnosis and management. Transient smartphone blindness is a new physiologic phenomenon caused by exposure to a certain level of smartphone bright light and the body posture of the smartphone user. It leads to the use of monocular vision to stare at the smartphone. By exploring recent literature, this study found that patients with TSB experienced retinal photopigment bleaching, which decreased light sensitivity. Typically, the sensitivity returned physiologically after several minutes. Patients with this blindness showed several symptoms. For example, they perceived shapes, outlines, or figures during the blackout. The diagnosis of TSB should be primarily based on a detailed history of smartphone use, with the differential diagnosis based on circumstance or occurrence. This diagnosis is useful to distinguish it from transient ischemic attack (TIA). Transient smartphone blindness is a basic monocular transient loss that does not require therapy or drugs. However, it was found that the reassurance of patients’ condition and suggestions on smartphone use were sufficient for the intervention. With a limited scientific study of TSB, this review is the first to raise the discussion topic. It is expected to help physicians to diagnose TSB significantly. In addition, this study will enrich the literature, particularly on the scientific and clinical mechanisms of recognising TSB for clinical diagnosis and management.
{"title":"Diagnosis and management of transient smartphone blindness: A literature review","authors":"Azzahra Afifah, Fara Syafira, Dini Dharmawidiarini","doi":"10.20885/jkki.vol14.iss3.art13","DOIUrl":"https://doi.org/10.20885/jkki.vol14.iss3.art13","url":null,"abstract":"The development of smartphones worldwide has rapidly increased the number of smartphone users. Although smartphones have many benefits, prolonged use causes various visual disorders, of which transient smartphone blindness (TSB) is one of the most important concerns. This study aims to analyse the phenomenon of TSB and explore its etiology, pathophysiology, symptoms, and examination to determine the diagnosis and management. Transient smartphone blindness is a new physiologic phenomenon caused by exposure to a certain level of smartphone bright light and the body posture of the smartphone user. It leads to the use of monocular vision to stare at the smartphone. By exploring recent literature, this study found that patients with TSB experienced retinal photopigment bleaching, which decreased light sensitivity. Typically, the sensitivity returned physiologically after several minutes. Patients with this blindness showed several symptoms. For example, they perceived shapes, outlines, or figures during the blackout. The diagnosis of TSB should be primarily based on a detailed history of smartphone use, with the differential diagnosis based on circumstance or occurrence. This diagnosis is useful to distinguish it from transient ischemic attack (TIA). Transient smartphone blindness is a basic monocular transient loss that does not require therapy or drugs. However, it was found that the reassurance of patients’ condition and suggestions on smartphone use were sufficient for the intervention. With a limited scientific study of TSB, this review is the first to raise the discussion topic. It is expected to help physicians to diagnose TSB significantly. In addition, this study will enrich the literature, particularly on the scientific and clinical mechanisms of recognising TSB for clinical diagnosis and management.","PeriodicalId":508182,"journal":{"name":"Jurnal Kedokteran dan Kesehatan Indonesia","volume":" 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139139250","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-12-30DOI: 10.20885/jkki.vol14.iss3.art5
Jatmiko Susilo, Dian Oktianti, Feronika Wiji Ashari, Ahmad Nurfahmi
Background: Dyslipidemia is widely known as a significant contributor to the incidence of cardiovascular diseases (CVD). Over the years, traditional therapeutic strategies, including the use of herbs, have been recognized. Marsilea crenata Presl. (MC), or a plant known for its phytoestrogen content, has shown biological activities similar to oestrogen. These activities comprise the reduction of serum cholesterol levels, thereby having potential roles in managing dyslipidaemia and its associated cardiovascular risks.Objective: This study aims to examine the effects of ethyl acetate extracts of MC leaves on the serum lipid profile of experimental rats with dyslipidaemia induced by high-fat diet (HFD). Methods: This study applied a pretest-post-test study design with control group, involving 30 rats which are divided into 5 treatment groups, namely N (normal), HFD, STA (Simvastatin), MC1, MC2, and MC3. Group N was only treated with standard feed, and the others received HFD on days 1-14. On the 15th – 28th day, the HFD group was treated with standard feed, and the STA group received simvastatin 0.36 mg/200 g BW/day. The groups of MC1, MC2, and MC3 were treated with oral MC extracts at 100, 200, and 400 mg/kgBW, respectively. Their body weight was measured at the beginning of the study, as well as after 2 and 4 weeks. Subsequently, the experimental rats were fasted overnight on the 14th and 28th day. Their blood was collected on the 15th day (pre-test) and 29th day (post-test) to measure serum concentration of total cholesterol (TC), triglycerides (TG), and high-density lipoprotein cholesterol (HDL-c). Low-density lipoprotein cholesterol (LDL-c) concentration was also calculated by using the Friedewald formula. Results: MC3 extracts significantly reduced the TC (-40.95 ± 1.77), TG (-46.12 ± 3.79), and LDL-c levels (-0.017 ± 0.010), and it also increased levels of HDL-c (11.28 ± 2.34) mg/dL in the HFD-induced rats.Conclusion: Ethyl acetate extracts of MC leaves could reduce risk factors for atherosclerosis by returning lipid profile of the dyslipidemic rats to normal conditions with an increased dose.
{"title":"Effects of ethyl acetate extracts of Marsilea crenata Presl. leaves on risks of atherosclerosis in dyslipidemic rats","authors":"Jatmiko Susilo, Dian Oktianti, Feronika Wiji Ashari, Ahmad Nurfahmi","doi":"10.20885/jkki.vol14.iss3.art5","DOIUrl":"https://doi.org/10.20885/jkki.vol14.iss3.art5","url":null,"abstract":"Background: Dyslipidemia is widely known as a significant contributor to the incidence of cardiovascular diseases (CVD). Over the years, traditional therapeutic strategies, including the use of herbs, have been recognized. Marsilea crenata Presl. (MC), or a plant known for its phytoestrogen content, has shown biological activities similar to oestrogen. These activities comprise the reduction of serum cholesterol levels, thereby having potential roles in managing dyslipidaemia and its associated cardiovascular risks.Objective: This study aims to examine the effects of ethyl acetate extracts of MC leaves on the serum lipid profile of experimental rats with dyslipidaemia induced by high-fat diet (HFD). Methods: This study applied a pretest-post-test study design with control group, involving 30 rats which are divided into 5 treatment groups, namely N (normal), HFD, STA (Simvastatin), MC1, MC2, and MC3. Group N was only treated with standard feed, and the others received HFD on days 1-14. On the 15th – 28th day, the HFD group was treated with standard feed, and the STA group received simvastatin 0.36 mg/200 g BW/day. The groups of MC1, MC2, and MC3 were treated with oral MC extracts at 100, 200, and 400 mg/kgBW, respectively. Their body weight was measured at the beginning of the study, as well as after 2 and 4 weeks. Subsequently, the experimental rats were fasted overnight on the 14th and 28th day. Their blood was collected on the 15th day (pre-test) and 29th day (post-test) to measure serum concentration of total cholesterol (TC), triglycerides (TG), and high-density lipoprotein cholesterol (HDL-c). Low-density lipoprotein cholesterol (LDL-c) concentration was also calculated by using the Friedewald formula. Results: MC3 extracts significantly reduced the TC (-40.95 ± 1.77), TG (-46.12 ± 3.79), and LDL-c levels (-0.017 ± 0.010), and it also increased levels of HDL-c (11.28 ± 2.34) mg/dL in the HFD-induced rats.Conclusion: Ethyl acetate extracts of MC leaves could reduce risk factors for atherosclerosis by returning lipid profile of the dyslipidemic rats to normal conditions with an increased dose.","PeriodicalId":508182,"journal":{"name":"Jurnal Kedokteran dan Kesehatan Indonesia","volume":" 11","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139141659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Unravelling anthrax transmission in Gunungkidul: A perspective of Islamic and medical studies","authors":"Yanasta Yudo Pratama, Naufal Arif Ismail, Kurniawan Dwi Saputra, Rofifah Miftahurrahmi","doi":"10.20885/jkki.vol14.iss3.art2","DOIUrl":"https://doi.org/10.20885/jkki.vol14.iss3.art2","url":null,"abstract":"","PeriodicalId":508182,"journal":{"name":"Jurnal Kedokteran dan Kesehatan Indonesia","volume":"41 s2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139163486","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-12-22DOI: 10.20885/jkki.vol14.iss3.art3
E. N. Sakinah, Nabil Athoillah, Komang Yunita Wiryaning Putri, Yunita Armiyanti
Background: In the last few decades, many studies have shown that pesticides have a close relationship with increasing blood glucose levels and the incidence of diabetes. Some examples of pesticides include fenthion, permethrin, and carbaryl. Recently, free fatty acid receptor 2 (FFAR2) was identified as having a critical function in preventing insulin resistance. Activation of FFAR2 will reduce fat accumulation and induce glucagon-like peptide 1 (GLP-1) secretion, which plays an important role in regulating type 2 diabetes mellitus (T2DM) prevention.Objective: This study aims to determine a comparison of the binding ability between fenthion, permethrin, and carbaryl to FFAR2 protein for predicting the mechanism of pesticide toxicity to T2DM through an in silico study.Methods: This is an exploratory bioinformatic study. The protein structure was FFAR2 receptor (UniProt: O15552), while the ligand was fenthion (PubChem CID: 3346), permethrin (PubChem CID: 40326), and carbaryl (PubChem CID: 6129). This molecular docking was conducted in October 2022 using Asus X202XE with Intel® Core™ i3-3217U CPU equipped with BIOVIA Discovery Studio, AutoDockTools, and AutoDock Vina. Results: The binding affinity values generated after docking between fenthion, permethrin, and carbaryl with FFAR2 indicate that the binding affinity comparison is permethrin < carbaryl < fenthion. This explains that permethrin could form a stronger bond with FFAR2 protein than other pesticides. However, the visualisation results of the form of bond interactions show that permethrin does not bind to the active site of FFAR2, so it could not be called an inhibitor. This is different from fenthion and carbaryl, which could bind to several amino acid residues on the active site of FFAR2 and have the potential to become inhibitors.Conclusion: Carbaryl is a pesticide with the strongest FFAR2 inhibitor. Carbaryl could cause type 2 DM through its inhibitory pathway to FFAR2.
{"title":"In silico determination of fenthion, permethrin, and carbaryl as FFAR2 inhibitors: Type 2 diabetes mellitus pathomechanism study","authors":"E. N. Sakinah, Nabil Athoillah, Komang Yunita Wiryaning Putri, Yunita Armiyanti","doi":"10.20885/jkki.vol14.iss3.art3","DOIUrl":"https://doi.org/10.20885/jkki.vol14.iss3.art3","url":null,"abstract":"Background: In the last few decades, many studies have shown that pesticides have a close relationship with increasing blood glucose levels and the incidence of diabetes. Some examples of pesticides include fenthion, permethrin, and carbaryl. Recently, free fatty acid receptor 2 (FFAR2) was identified as having a critical function in preventing insulin resistance. Activation of FFAR2 will reduce fat accumulation and induce glucagon-like peptide 1 (GLP-1) secretion, which plays an important role in regulating type 2 diabetes mellitus (T2DM) prevention.Objective: This study aims to determine a comparison of the binding ability between fenthion, permethrin, and carbaryl to FFAR2 protein for predicting the mechanism of pesticide toxicity to T2DM through an in silico study.Methods: This is an exploratory bioinformatic study. The protein structure was FFAR2 receptor (UniProt: O15552), while the ligand was fenthion (PubChem CID: 3346), permethrin (PubChem CID: 40326), and carbaryl (PubChem CID: 6129). This molecular docking was conducted in October 2022 using Asus X202XE with Intel® Core™ i3-3217U CPU equipped with BIOVIA Discovery Studio, AutoDockTools, and AutoDock Vina. Results: The binding affinity values generated after docking between fenthion, permethrin, and carbaryl with FFAR2 indicate that the binding affinity comparison is permethrin < carbaryl < fenthion. This explains that permethrin could form a stronger bond with FFAR2 protein than other pesticides. However, the visualisation results of the form of bond interactions show that permethrin does not bind to the active site of FFAR2, so it could not be called an inhibitor. This is different from fenthion and carbaryl, which could bind to several amino acid residues on the active site of FFAR2 and have the potential to become inhibitors.Conclusion: Carbaryl is a pesticide with the strongest FFAR2 inhibitor. Carbaryl could cause type 2 DM through its inhibitory pathway to FFAR2.","PeriodicalId":508182,"journal":{"name":"Jurnal Kedokteran dan Kesehatan Indonesia","volume":"106 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139164061","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-12-22DOI: 10.20885/jkki.vol14.iss3.art1
F. Arjadi
{"title":"The neuroprotective effects of exercise on memory","authors":"F. Arjadi","doi":"10.20885/jkki.vol14.iss3.art1","DOIUrl":"https://doi.org/10.20885/jkki.vol14.iss3.art1","url":null,"abstract":"","PeriodicalId":508182,"journal":{"name":"Jurnal Kedokteran dan Kesehatan Indonesia","volume":"3 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139164752","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-08-31DOI: 10.20885/jkki.vol14.iss2.art10
O. B. Kujariningrum, Sri Winarni, Kharisma Olivia Anugrah Cahyani, Nadia Puji Anggitasari, Waviq Azizah
In Indonesia, the noni plant (Morinda citrifolia L.) has gained popularity as an alternative treatment for various diseases. Cancer is the second cause of death worldwide, with chemotherapy as the primary treatment. There is growing interest in exploring phytochemicals found in noni plants such as anthraquinones, chitosan, phenols, and flavonoids. These antioxidant compounds hold potential as alternative treatments for cancer. This study explores the active compounds in noni plants that exhibit anti-cancer properties. This study employed a scoping review approach. Previous original articles were retrieved from Scopus, Science Direct, ClinicalKey, Springer Link, and Google Scholar with keywords in Morinda citrifolia L., component, bioactive, antioxidant, anti-inflammatory, and anti-cancer. We included 34 articles that met the inclusion criteria. The findings of this study highlight the anti-cancer activity of several phytochemicals found in noni plants. Damnacanthal has been shown to reduce the number of MCF-7 cells. Nordamnacanthal inhibited the development of the H400 cell cycle by increasing the activity of Cytochrome C, Caspase-9, and Caspase 3/7 and induced the death of MDA-MB231 and MCF-7 cells. Chitosan nanoparticles can inhibit the growth of A549 cells. Scopoletin can inhibit cancer cell proliferation by inducing cells in the G0 / G1 and S phases. Epicatechin can inhibit the growth of PC-9 cells. Damnachanthal, nordamnacanthal, chitosan nanoparticles, scopoletin, and epicatechin are active compounds presented in noni plants that can act as anti-cancer.
在印度尼西亚，诺丽果（Morinda citrifolia L.）作为一种治疗各种疾病的替代疗法受到人们的欢迎。癌症是全球第二大死因，主要治疗方法是化疗。人们对探索诺丽果植物中的植物化学物质（如蒽醌、壳聚糖、酚类和类黄酮）的兴趣与日俱增。这些抗氧化化合物具有作为癌症替代疗法的潜力。本研究探讨了诺丽果中具有抗癌特性的活性化合物。本研究采用了范围综述的方法。我们从 Scopus、Science Direct、ClinicalKey、Springer Link 和 Google Scholar 中检索了以前的原创文章，关键词包括海巴戟、成分、生物活性、抗氧化、抗炎和抗癌。我们共收录了 34 篇符合纳入标准的文章。这项研究的结果突显了诺丽果中几种植物化学物质的抗癌活性。研究表明，诺丽果中的 Damnacanthal 能减少 MCF-7 细胞的数量。Nordamnacanthal通过增加细胞色素C、Caspase-9和Caspase 3/7的活性，抑制H400细胞周期的发展，并诱导MDA-MB231和MCF-7细胞死亡。壳聚糖纳米颗粒能抑制 A549 细胞的生长。莨菪亭能通过诱导细胞进入 G0 / G1 和 S 期来抑制癌细胞增殖。表儿茶素能抑制 PC-9 细胞的生长。Damnachanthal、nordamnacanthal、壳聚糖纳米颗粒、莨菪亭和表儿茶素是诺丽果植物中的活性化合物，具有抗癌作用。
{"title":"Bioactives of noni plant (Morinda citrifolia L.) as anti-cancer herbals: A scoping review","authors":"O. B. Kujariningrum, Sri Winarni, Kharisma Olivia Anugrah Cahyani, Nadia Puji Anggitasari, Waviq Azizah","doi":"10.20885/jkki.vol14.iss2.art10","DOIUrl":"https://doi.org/10.20885/jkki.vol14.iss2.art10","url":null,"abstract":"In Indonesia, the noni plant (Morinda citrifolia L.) has gained popularity as an alternative treatment for various diseases. Cancer is the second cause of death worldwide, with chemotherapy as the primary treatment. There is growing interest in exploring phytochemicals found in noni plants such as anthraquinones, chitosan, phenols, and flavonoids. These antioxidant compounds hold potential as alternative treatments for cancer. This study explores the active compounds in noni plants that exhibit anti-cancer properties. This study employed a scoping review approach. Previous original articles were retrieved from Scopus, Science Direct, ClinicalKey, Springer Link, and Google Scholar with keywords in Morinda citrifolia L., component, bioactive, antioxidant, anti-inflammatory, and anti-cancer. We included 34 articles that met the inclusion criteria. The findings of this study highlight the anti-cancer activity of several phytochemicals found in noni plants. Damnacanthal has been shown to reduce the number of MCF-7 cells. Nordamnacanthal inhibited the development of the H400 cell cycle by increasing the activity of Cytochrome C, Caspase-9, and Caspase 3/7 and induced the death of MDA-MB231 and MCF-7 cells. Chitosan nanoparticles can inhibit the growth of A549 cells. Scopoletin can inhibit cancer cell proliferation by inducing cells in the G0 / G1 and S phases. Epicatechin can inhibit the growth of PC-9 cells. Damnachanthal, nordamnacanthal, chitosan nanoparticles, scopoletin, and epicatechin are active compounds presented in noni plants that can act as anti-cancer.","PeriodicalId":508182,"journal":{"name":"Jurnal Kedokteran dan Kesehatan Indonesia","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139347397","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-08-31DOI: 10.20885/jkki.vol14.iss2.art8
Elman Boy, Rudi Iskandar Hasibuan, Ashil Muhammad Abdul Rasyid, Nugraha Ilhamsyah, Cut Shanaz Dhiya Shafira, Annisa Fitri Hendewi, Raudatul Husna Pranata, Putri Maulia Amami Harun
Background: Breast milk and complementary feeding are important sources of nutrition in the first 1000 days of life, so nutritional deficiencies in this period of life cause problems in both short and long terms. Hence, investigating the association between breastfeeding, complementary feeding history, and toddlers’ nutritional status is important.Objective: This study aims to assess the influence of exclusive breastfeeding and timely complementary feeding on the nutritional status of children under five.Methods: This cross-sectional study was conducted in a Public Health Centre (Puskesmas) in Medan, North Sumatera. Data regarding the toddlers’ height and weight were obtained through direct measurements, whereas information about breastfeeding and complementary feeding history was gathered through interviews with the toddlers’ mothers. Chi-square analysis was performed for statistical analysis.Results: The study involved 50 toddlers, 30 boys and 20 girls. Among them, 58% received both exclusive breastfeeding and timely complementary feeding, while 42% did not. Among toddlers who received exclusive breastfeeding and timely complementary feeding, 82.7% demonstrated normal nutritional status, whereas 10% experienced malnutrition. Conversely, in toddlers not given exclusive breastfeeding and timely complementary foods, only 38% had normal nutrition, with the remaining 62% facing malnutrition. There was an association between exclusive breastfeeding, timely complementary feeding, and toddlers’ nutritional status (P < 0.05). Toddlers receiving exclusive breastfeeding had 7.8 times higher odds of experiencing normal nutritional status compared to those without it. Similarly, toddlers exposed to timely complementary feeding had 4.3 times higher odds of experiencing normal nutrition.Conclusion: Exclusive breastfeeding and timely complementary feeding played an important role in the nutritional status of toddlers.
{"title":"The impact of exclusive breastfeeding and timely complementary feeding on the nutritional status of toddlers","authors":"Elman Boy, Rudi Iskandar Hasibuan, Ashil Muhammad Abdul Rasyid, Nugraha Ilhamsyah, Cut Shanaz Dhiya Shafira, Annisa Fitri Hendewi, Raudatul Husna Pranata, Putri Maulia Amami Harun","doi":"10.20885/jkki.vol14.iss2.art8","DOIUrl":"https://doi.org/10.20885/jkki.vol14.iss2.art8","url":null,"abstract":"Background: Breast milk and complementary feeding are important sources of nutrition in the first 1000 days of life, so nutritional deficiencies in this period of life cause problems in both short and long terms. Hence, investigating the association between breastfeeding, complementary feeding history, and toddlers’ nutritional status is important.Objective: This study aims to assess the influence of exclusive breastfeeding and timely complementary feeding on the nutritional status of children under five.Methods: This cross-sectional study was conducted in a Public Health Centre (Puskesmas) in Medan, North Sumatera. Data regarding the toddlers’ height and weight were obtained through direct measurements, whereas information about breastfeeding and complementary feeding history was gathered through interviews with the toddlers’ mothers. Chi-square analysis was performed for statistical analysis.Results: The study involved 50 toddlers, 30 boys and 20 girls. Among them, 58% received both exclusive breastfeeding and timely complementary feeding, while 42% did not. Among toddlers who received exclusive breastfeeding and timely complementary feeding, 82.7% demonstrated normal nutritional status, whereas 10% experienced malnutrition. Conversely, in toddlers not given exclusive breastfeeding and timely complementary foods, only 38% had normal nutrition, with the remaining 62% facing malnutrition. There was an association between exclusive breastfeeding, timely complementary feeding, and toddlers’ nutritional status (P < 0.05). Toddlers receiving exclusive breastfeeding had 7.8 times higher odds of experiencing normal nutritional status compared to those without it. Similarly, toddlers exposed to timely complementary feeding had 4.3 times higher odds of experiencing normal nutrition.Conclusion: Exclusive breastfeeding and timely complementary feeding played an important role in the nutritional status of toddlers.","PeriodicalId":508182,"journal":{"name":"Jurnal Kedokteran dan Kesehatan Indonesia","volume":"5 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139347282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-08-31DOI: 10.20885/jkki.vol14.iss2.art15
Singgih Annas Fuadhi, A. Handaya, Agus Barmawi, Imam Sofii, Nurcahya Setyawan
Laparoscopic common bile duct exploration (LCBDE) is a relevant therapeutic option in managing cholecysto-choledocholithiasis. The success of this procedure is highly dependent on selecting an appropriate method, either transcystic or transcoledocal. Intraoperative choledochoscopy proves its importance in evaluating the condition of the choledochal duct and sphincter of Oddi. In this case series, we report 2 cases of patients with complaints of right upper abdominal pain and jaundice. Both patients were diagnosed with multiple cholecysto-choledocholithiasis at Dr. Sardjito Hospital, Yogyakarta. The interventional measures applied to both patients were transcystic and transcoledocal exploration. In the first patient, the transcystic method was chosen because the cystic duct was widening up to 9 mm in diameter. While in the second patient, the transcoledocal method was taken because the diameter of the cystic duct was still within normal limits. The duration of surgery in transcystic surgery was shorter than in transcoledocal surgery, with a time ratio of 129 minutes versus 162 minutes. Postoperatively, both patients were discharged on the second day after the procedure, and both experienced recovery without any significant complications. Overall, LCBDE has been shown to be safe to perform. The one-stage surgical approach has been shown to reduce the risk of complications, cost, and duration of treatment required. The choice between the transcystic or transcoledocal method should be based on each patient’s clinical condition.
{"title":"Transcystic versus transcholedochal laparoscopic common bile duct exploration: Choosing the right approach – A Case Series","authors":"Singgih Annas Fuadhi, A. Handaya, Agus Barmawi, Imam Sofii, Nurcahya Setyawan","doi":"10.20885/jkki.vol14.iss2.art15","DOIUrl":"https://doi.org/10.20885/jkki.vol14.iss2.art15","url":null,"abstract":"Laparoscopic common bile duct exploration (LCBDE) is a relevant therapeutic option in managing cholecysto-choledocholithiasis. The success of this procedure is highly dependent on selecting an appropriate method, either transcystic or transcoledocal. Intraoperative choledochoscopy proves its importance in evaluating the condition of the choledochal duct and sphincter of Oddi. In this case series, we report 2 cases of patients with complaints of right upper abdominal pain and jaundice. Both patients were diagnosed with multiple cholecysto-choledocholithiasis at Dr. Sardjito Hospital, Yogyakarta. The interventional measures applied to both patients were transcystic and transcoledocal exploration. In the first patient, the transcystic method was chosen because the cystic duct was widening up to 9 mm in diameter. While in the second patient, the transcoledocal method was taken because the diameter of the cystic duct was still within normal limits. The duration of surgery in transcystic surgery was shorter than in transcoledocal surgery, with a time ratio of 129 minutes versus 162 minutes. Postoperatively, both patients were discharged on the second day after the procedure, and both experienced recovery without any significant complications. Overall, LCBDE has been shown to be safe to perform. The one-stage surgical approach has been shown to reduce the risk of complications, cost, and duration of treatment required. The choice between the transcystic or transcoledocal method should be based on each patient’s clinical condition.","PeriodicalId":508182,"journal":{"name":"Jurnal Kedokteran dan Kesehatan Indonesia","volume":"16 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139347497","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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