首页 > 最新文献

Aktuelle Rheumatologie最新文献

英文 中文
Bariatrische Operation führt nicht zu niedrigem Knie- und Hüftarthrose-Risiko 减肥手术不会降低膝关节和髋关节骨性关节炎的风险
IF 0.2 4区 医学 Q4 RHEUMATOLOGY Pub Date : 2023-11-28 DOI: 10.1055/a-2117-6602
Die bariatrische Chirurgie ist eine wirksame Adipositastherapie, die zu einer langfristigen Gewichtsreduzierung führt. Bisher wurde nicht gezeigt, ob die bariatrische Chirurgie mit einem geringeren Risiko für Hüft- und Kniearthrose und einer Verringerung des Bedarfs an Arthroplastik einhergeht. Lohmander et al. untersuchten das langfristige Arthroserisiko und die Notwendigkeit von Hüft- und Knieendoprothesen nach bariatrischen Operationen.
减肥手术是一种有效的肥胖症治疗方法,可长期减轻体重。迄今为止,减肥手术是否与降低髋关节和膝关节骨关节炎的风险以及减少关节置换术的需求相关,尚未得到证实。 Lohmander 等人对减肥手术后骨关节炎的长期风险以及髋关节和膝关节置换术的需求进行了调查。
{"title":"Bariatrische Operation führt nicht zu niedrigem Knie- und Hüftarthrose-Risiko","authors":"","doi":"10.1055/a-2117-6602","DOIUrl":"https://doi.org/10.1055/a-2117-6602","url":null,"abstract":"Die bariatrische Chirurgie ist eine wirksame Adipositastherapie, die zu einer langfristigen Gewichtsreduzierung führt. Bisher wurde nicht gezeigt, ob die bariatrische Chirurgie mit einem geringeren Risiko für Hüft- und Kniearthrose und einer Verringerung des Bedarfs an Arthroplastik einhergeht. Lohmander et al. untersuchten das langfristige Arthroserisiko und die Notwendigkeit von Hüft- und Knieendoprothesen nach bariatrischen Operationen.","PeriodicalId":50831,"journal":{"name":"Aktuelle Rheumatologie","volume":"252 1","pages":""},"PeriodicalIF":0.2,"publicationDate":"2023-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139221786","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Kniearthrose: GLAD-Programm wirkt nicht besser als Placebo 膝关节骨关节炎:GLAD 计划并不比安慰剂更有效
IF 0.2 4区 医学 Q4 RHEUMATOLOGY Pub Date : 2023-11-28 DOI: 10.1055/a-2117-6664
Zur Behandlung einer Arthrose wird eine Bewegungstherapie in Kombination mit einer Patientenaufklärung empfohlen. Auf der Grundlage dieser Empfehlungen wurde das Programm Good Life with Osteoarthritis in Denmark (GLAD) entwickelt und in mehreren Ländern weltweit eingeführt. Henriksen et al. bewerteten GLAD im Vergleich zu einem Placebo auf die Behandlungsresultate.
建议在治疗骨关节炎时将运动疗法与患者教育相结合。根据这些建议,丹麦制定了 "骨关节炎患者的美好生活"(GLAD)计划,并在全球多个国家推行。 Henriksen 等人对 GLAD 与安慰剂的治疗效果进行了比较评估。
{"title":"Kniearthrose: GLAD-Programm wirkt nicht besser als Placebo","authors":"","doi":"10.1055/a-2117-6664","DOIUrl":"https://doi.org/10.1055/a-2117-6664","url":null,"abstract":"Zur Behandlung einer Arthrose wird eine Bewegungstherapie in Kombination mit einer Patientenaufklärung empfohlen. Auf der Grundlage dieser Empfehlungen wurde das Programm Good Life with Osteoarthritis in Denmark (GLAD) entwickelt und in mehreren Ländern weltweit eingeführt. Henriksen et al. bewerteten GLAD im Vergleich zu einem Placebo auf die Behandlungsresultate.","PeriodicalId":50831,"journal":{"name":"Aktuelle Rheumatologie","volume":"26 1","pages":""},"PeriodicalIF":0.2,"publicationDate":"2023-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139224664","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
axSpA-Patienten haben häufig arbeitsbezogene Probleme axSpA 患者经常会出现与工作相关的问题
IF 0.2 4区 医学 Q4 RHEUMATOLOGY Pub Date : 2023-11-28 DOI: 10.1055/a-2117-6716
Eine Zunahme der Krankheitsaktivität der axialen Spondyloarthritis (axSpA) ist mit einem Verlust an Arbeitsproduktivität verbunden, was eine größere Krankheitslast und höhere Kosten für die Gesellschaft bedeutet. Zudem haben axSpA-Patienten oftmals Schwierigkeiten, in ihrem Beruf voranzukommen. Inman et al. untersuchten Faktoren, die mit arbeitsbezogenen Problemen bei kanadischen axSpA-Patienten in Verbindung stehen.
轴性脊柱关节炎(axSpA)疾病活动度的增加与劳动生产率的下降有关,这意味着疾病负担加重,社会成本增加。此外,axSpA 患者在职业生涯中往往难以晋升。Inman等人调查了加拿大轴性SpA患者工作相关问题的相关因素。
{"title":"axSpA-Patienten haben häufig arbeitsbezogene Probleme","authors":"","doi":"10.1055/a-2117-6716","DOIUrl":"https://doi.org/10.1055/a-2117-6716","url":null,"abstract":"Eine Zunahme der Krankheitsaktivität der axialen Spondyloarthritis (axSpA) ist mit einem Verlust an Arbeitsproduktivität verbunden, was eine größere Krankheitslast und höhere Kosten für die Gesellschaft bedeutet. Zudem haben axSpA-Patienten oftmals Schwierigkeiten, in ihrem Beruf voranzukommen. Inman et al. untersuchten Faktoren, die mit arbeitsbezogenen Problemen bei kanadischen axSpA-Patienten in Verbindung stehen.","PeriodicalId":50831,"journal":{"name":"Aktuelle Rheumatologie","volume":"59 1","pages":""},"PeriodicalIF":0.2,"publicationDate":"2023-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139226944","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Anti-C5aR-Antikörper geben Aufschluss zu AAV-Krankheitsaktivität 抗 C5aR 抗体提供有关 AAV 疾病活动的信息
IF 0.2 4区 医学 Q4 RHEUMATOLOGY Pub Date : 2023-11-28 DOI: 10.1055/a-2117-6752
Die durch den G-Protein-gekoppelten Rezeptor C5aR gesteuerte Rekrutierung von Neutrophilen, Aktivierung und Entzündung spielt eine wichtige Rolle in der Pathogenese der antineutrophilen zytoplasmatischen Autoantikörper (ANCA)- assoziierten Vaskulitis (AAV). Interessanterweise werden Antikörper, die u. a. auf C5aR abzielen, in niedrigen Konzentrationen auch bei gesunden Menschen nachgewiesen. Klapa et al. untersuchten die Zusammenhänge.
由 G 蛋白偶联受体 C5aR 驱动的中性粒细胞募集、活化和炎症在抗中性粒细胞胞浆自身抗体(ANCA)相关性血管炎(AAV)的发病机制中起着重要作用。有趣的是,在健康人体内也能检测到低浓度的针对 C5aR 等的抗体。克拉帕(Klapa)等人研究了其中的相关性。
{"title":"Anti-C5aR-Antikörper geben Aufschluss zu AAV-Krankheitsaktivität","authors":"","doi":"10.1055/a-2117-6752","DOIUrl":"https://doi.org/10.1055/a-2117-6752","url":null,"abstract":"Die durch den G-Protein-gekoppelten Rezeptor C5aR gesteuerte Rekrutierung von Neutrophilen, Aktivierung und Entzündung spielt eine wichtige Rolle in der Pathogenese der antineutrophilen zytoplasmatischen Autoantikörper (ANCA)- assoziierten Vaskulitis (AAV). Interessanterweise werden Antikörper, die u. a. auf C5aR abzielen, in niedrigen Konzentrationen auch bei gesunden Menschen nachgewiesen. Klapa et al. untersuchten die Zusammenhänge.","PeriodicalId":50831,"journal":{"name":"Aktuelle Rheumatologie","volume":"52 1","pages":""},"PeriodicalIF":0.2,"publicationDate":"2023-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139225673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Rheumatoide Arthritis: Sozioökonomische Instabilität begünstigt Behinderungen 类风湿性关节炎:社会经济的不稳定性会导致残疾
IF 0.2 4区 医学 Q4 RHEUMATOLOGY Pub Date : 2023-11-28 DOI: 10.1055/a-2117-6690
Dank der modernen Therapien gelingt es bei der Mehrzahl der Menschen mit einer rheumatoiden Arthritis (RA), die Inflammation langfristig gut unter Kontrolle zu halten. Bei vielen Betroffenen spiegelt sich dieser Behandlungserfolg allerdings nicht in einer Reduktion von Behinderungen wider. Liegt das möglicherweise an sozialen, ökonomischen oder Lebensstilfaktoren? Und welche Rolle spielen diesbezüglich Schmerzen, Angst, Fatigue und Depressionen?
得益于现代疗法,大多数类风湿性关节炎(RA)患者都能长期控制炎症。然而,对于许多患者来说,治疗的成功并没有体现在残疾程度的减轻上。这可能是社会、经济或生活方式因素造成的吗?疼痛、焦虑、疲劳和抑郁在这方面又起了什么作用?
{"title":"Rheumatoide Arthritis: Sozioökonomische Instabilität begünstigt Behinderungen","authors":"","doi":"10.1055/a-2117-6690","DOIUrl":"https://doi.org/10.1055/a-2117-6690","url":null,"abstract":"Dank der modernen Therapien gelingt es bei der Mehrzahl der Menschen mit einer rheumatoiden Arthritis (RA), die Inflammation langfristig gut unter Kontrolle zu halten. Bei vielen Betroffenen spiegelt sich dieser Behandlungserfolg allerdings nicht in einer Reduktion von Behinderungen wider. Liegt das möglicherweise an sozialen, ökonomischen oder Lebensstilfaktoren? Und welche Rolle spielen diesbezüglich Schmerzen, Angst, Fatigue und Depressionen?","PeriodicalId":50831,"journal":{"name":"Aktuelle Rheumatologie","volume":"51 1","pages":""},"PeriodicalIF":0.2,"publicationDate":"2023-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139221480","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Handchirurgie bei entzündlich rheumatischen Erkrankungen – ein Update 手部手术治疗炎症性风湿病--最新进展
IF 0.2 4区 医学 Q4 RHEUMATOLOGY Pub Date : 2023-11-22 DOI: 10.1055/a-2189-0527
R. Gaulke
Zusammenfassung Die peripheren Gelenke an Händen und Füßen sind bei entzündlich-rheumatischen Erkrankungen und hier insbesondere bei der rheumatoiden Arthritis und bei Arthritis psoriatica sehr häufig von der Entzündung betroffen. Neben den Gelenken sind besonders die Entzündungen der Sehnenscheiden zu beachten, da diese unbehandelt zu einer Durchwanderung der Sehne führen können welche dann Defektrupturen bedingen. Die Rekonstruktion dieser langstreckig geschädigten Sehnen ist aufwendig und die Ergebnisse sind schlechter als die der Tenosynovialektomie. Sollte eine ansonsten wirksamer Basistherapie an einzelnen Gelenken der Hand nicht zu einer Beruhigung der Entzündung führen, so ist die operative Synovialektomie zum Gelenkserhalt indiziert. Da neben den Gelenken der Hand auch häufig Destruktionen mit Bewegungseinschränkungen am Schulter- und Ellenbogengelenk auftreten, sollte bei Destruktionen im Handgelenk nicht generell eine komplette Arthrodese durchgeführt werden, so lange noch Gelenkkompartimente erhalten sind. Es bestehen zahlreiche Möglichkeiten durch karpale Teilarthrodesen die Schmerzen zu nehmen, das Handgelenk zu stabilisieren und eine Restbeweglichkeit zu erhalten. Für instabile und destruierte Fingergrundgelenke ist der Swanson-Spacer weiterhin der Goldstandard. Für die Fingermittelgelenke steht mittlerweile seit mehreren Jahren ein Oberflächenersatz zur Verfügung, welcher eine gute Osteointegration zeigt und damit die stielgeführten Prothesen, die in der Regel nicht einheilen oder gehäuft zu periprothetischen Frakturen führen, abgelöst hat. Die Operation sollte an der entzündlich-rheumatisch veränderten Hand streng aber dennoch konsequent und ohne zeitliche Verzögerung gestellt werden, um so viele Gelenke wie möglich zu erhalten. Da viele Destruktionen und Fehlstellungen entzündlich-rheumatischer Genese radiologisch posttraumatischen und degenerativen Veränderungen ähneln, aber dennoch unterschiedlicher chirurgischer Therapie bedürfen, sollten diese dem orthopädischen Rheumatologen zugeführt werden, um das bestmögliche Ergebnis zu erzielen und Folgeoperation möglichst zu vermeiden.
摘要 炎症性风湿病,尤其是类风湿性关节炎和银屑病关节炎,常常会影响手脚的外周关节。除关节外,还必须特别注意腱鞘的炎症,因为如果不及时治疗,可能会导致肌腱移位,进而造成缺损断裂。重建这些广泛受损的肌腱非常复杂,而且效果比腱鞘切除术更差。如果对个别手部关节进行有效的基础治疗仍不能使炎症得到缓解,则需要进行滑膜切除手术以保留关节。除手部关节外,肩关节和肘关节也经常出现活动受限的破坏,因此在腕关节破坏的情况下,只要关节腔仍能保留,一般不应进行完全的关节切除术。通过腕关节部分切除术来缓解疼痛、稳定腕关节并保持残余活动度的方法有很多。斯旺森垫片仍是治疗不稳定和已损坏掌指关节的黄金标准。几年来,掌指关节表面替代物已经问世,显示出良好的骨整合性,从而取代了骨干引导假体,后者通常无法愈合或经常导致假体周围骨折。对有风湿性炎症病变的手部进行手术时,应严格、一致、毫不拖延,以尽可能多地保留关节。由于许多风湿性炎症引起的破坏和畸形在影像学上与创伤后和退行性病变相似,但仍需要不同的手术治疗,因此应将其转诊至风湿骨科医生处,以达到最佳效果,并尽可能避免后续手术。
{"title":"Handchirurgie bei entzündlich rheumatischen Erkrankungen – ein Update","authors":"R. Gaulke","doi":"10.1055/a-2189-0527","DOIUrl":"https://doi.org/10.1055/a-2189-0527","url":null,"abstract":"Zusammenfassung Die peripheren Gelenke an Händen und Füßen sind bei entzündlich-rheumatischen Erkrankungen und hier insbesondere bei der rheumatoiden Arthritis und bei Arthritis psoriatica sehr häufig von der Entzündung betroffen. Neben den Gelenken sind besonders die Entzündungen der Sehnenscheiden zu beachten, da diese unbehandelt zu einer Durchwanderung der Sehne führen können welche dann Defektrupturen bedingen. Die Rekonstruktion dieser langstreckig geschädigten Sehnen ist aufwendig und die Ergebnisse sind schlechter als die der Tenosynovialektomie. Sollte eine ansonsten wirksamer Basistherapie an einzelnen Gelenken der Hand nicht zu einer Beruhigung der Entzündung führen, so ist die operative Synovialektomie zum Gelenkserhalt indiziert. Da neben den Gelenken der Hand auch häufig Destruktionen mit Bewegungseinschränkungen am Schulter- und Ellenbogengelenk auftreten, sollte bei Destruktionen im Handgelenk nicht generell eine komplette Arthrodese durchgeführt werden, so lange noch Gelenkkompartimente erhalten sind. Es bestehen zahlreiche Möglichkeiten durch karpale Teilarthrodesen die Schmerzen zu nehmen, das Handgelenk zu stabilisieren und eine Restbeweglichkeit zu erhalten. Für instabile und destruierte Fingergrundgelenke ist der Swanson-Spacer weiterhin der Goldstandard. Für die Fingermittelgelenke steht mittlerweile seit mehreren Jahren ein Oberflächenersatz zur Verfügung, welcher eine gute Osteointegration zeigt und damit die stielgeführten Prothesen, die in der Regel nicht einheilen oder gehäuft zu periprothetischen Frakturen führen, abgelöst hat. Die Operation sollte an der entzündlich-rheumatisch veränderten Hand streng aber dennoch konsequent und ohne zeitliche Verzögerung gestellt werden, um so viele Gelenke wie möglich zu erhalten. Da viele Destruktionen und Fehlstellungen entzündlich-rheumatischer Genese radiologisch posttraumatischen und degenerativen Veränderungen ähneln, aber dennoch unterschiedlicher chirurgischer Therapie bedürfen, sollten diese dem orthopädischen Rheumatologen zugeführt werden, um das bestmögliche Ergebnis zu erzielen und Folgeoperation möglichst zu vermeiden.","PeriodicalId":50831,"journal":{"name":"Aktuelle Rheumatologie","volume":"160 1","pages":""},"PeriodicalIF":0.2,"publicationDate":"2023-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139248636","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Erratum: Adherence to Colchicine During Pregnancy in Familial Mediterranean Fever Patients: Reasons for Cessation and Outcomes from a Single-Centre Experience 勘误:家族性地中海热患者在怀孕期间坚持服用秋水仙碱:单中心经验中的停药原因和结果
IF 0.2 4区 医学 Q4 RHEUMATOLOGY Pub Date : 2023-11-02 DOI: 10.1055/a-2189-8554
İsmail Dogan, S. Güven, Ö. Karakaş, Esra Kayacan Erdoğan, Ş. Erten
{"title":"Erratum: Adherence to Colchicine During Pregnancy in Familial Mediterranean Fever Patients: Reasons for Cessation and Outcomes from a Single-Centre Experience","authors":"İsmail Dogan, S. Güven, Ö. Karakaş, Esra Kayacan Erdoğan, Ş. Erten","doi":"10.1055/a-2189-8554","DOIUrl":"https://doi.org/10.1055/a-2189-8554","url":null,"abstract":"","PeriodicalId":50831,"journal":{"name":"Aktuelle Rheumatologie","volume":"9 1","pages":""},"PeriodicalIF":0.2,"publicationDate":"2023-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139290371","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Classification Criteria For Early Knee Osteoarthritis: A Review Article 早期膝关节骨关节炎的分类标准:综述文章
4区 医学 Q4 RHEUMATOLOGY Pub Date : 2023-10-24 DOI: 10.1055/a-2173-1607
Luz Herrero-Manley, Ana Alabajos-Cea, Luis Suso-Martí, Enrique Viosca-Herrero
Abstract Objective The aim of this systematic review (SR) was to define the “state of the art” on classification criteria for early knee osteoarthritis (EKOA). Methods A systematic review was performed using MEDLINE (Pubmed), Web of Science, Scopus, EMBASE, PEDro, CINAHL and Google scholar databases. Two independent reviewers conducted the eligibility review. Any type of study that proposed diagnostic criteria of EKOA was included. Results Seven articles were included according to the inclusion criteria. The evidence presented in this SR shows that there is still no consensus regarding definition and classification of EKOA. At present, there are seven different proposals in the scientific literature, and they only agree on including knee pain and radiographic evaluation in their criteria, but they do not even consider the same situations for including these two factors. Conclusion There is still no consensus regarding definition and classification of EKOA. Knee pain and radiological assessment seem to be the most commonly used criteria, but due to the variability encountered, it is not possible to reach a consensus on a clear definition and diagnosis of EOKA.
摘要目的本系统综述(SR)的目的是定义早期膝关节骨关节炎(EKOA)分类标准的“最新技术”。方法采用MEDLINE (Pubmed)、Web of Science、Scopus、EMBASE、PEDro、CINAHL和谷歌学者数据库进行系统评价。两名独立审查员进行了资格审查。提出EKOA诊断标准的任何类型的研究都包括在内。结果7篇文献符合纳入标准。本SR中提出的证据表明,关于EKOA的定义和分类仍然没有共识。目前,在科学文献中有七种不同的建议,他们只同意在他们的标准中包括膝关节疼痛和放射学评估,但他们甚至没有考虑到包括这两个因素的相同情况。结论对EKOA的定义和分类尚无共识。膝关节疼痛和放射学评估似乎是最常用的标准,但由于遇到的可变性,不可能就EOKA的明确定义和诊断达成共识。
{"title":"Classification Criteria For Early Knee Osteoarthritis: A Review Article","authors":"Luz Herrero-Manley, Ana Alabajos-Cea, Luis Suso-Martí, Enrique Viosca-Herrero","doi":"10.1055/a-2173-1607","DOIUrl":"https://doi.org/10.1055/a-2173-1607","url":null,"abstract":"Abstract Objective The aim of this systematic review (SR) was to define the “state of the art” on classification criteria for early knee osteoarthritis (EKOA). Methods A systematic review was performed using MEDLINE (Pubmed), Web of Science, Scopus, EMBASE, PEDro, CINAHL and Google scholar databases. Two independent reviewers conducted the eligibility review. Any type of study that proposed diagnostic criteria of EKOA was included. Results Seven articles were included according to the inclusion criteria. The evidence presented in this SR shows that there is still no consensus regarding definition and classification of EKOA. At present, there are seven different proposals in the scientific literature, and they only agree on including knee pain and radiographic evaluation in their criteria, but they do not even consider the same situations for including these two factors. Conclusion There is still no consensus regarding definition and classification of EKOA. Knee pain and radiological assessment seem to be the most commonly used criteria, but due to the variability encountered, it is not possible to reach a consensus on a clear definition and diagnosis of EOKA.","PeriodicalId":50831,"journal":{"name":"Aktuelle Rheumatologie","volume":"53 4","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135266384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Portuguese state of the art on osteoporosis and fracture risk: an update on the treatment options 葡萄牙骨质疏松症和骨折风险的最新技术:治疗方案的最新进展
4区 医学 Q4 RHEUMATOLOGY Pub Date : 2023-10-24 DOI: 10.1055/a-2158-0872
Diogo Ramalho, Gustavo Melo Rocha, Maria João Oliveira
Abstract Osteoporosis and fragility fractures are serious public health problems, which greatly impact individual health and the economy of other health services. Pharmacological treatment is still one of the main elements of clinical intervention, combined with non-pharmacological measures, in preventing the occurrence of fragility fractures. The emergence of promising new pharmacological options in the treatment of osteoporosis seems to renew expectations in the prevention of complications and a subsequent reduction in morbidity and mortality, including symptomatic treatment, improved physical function and a better quality of life. This review aims to provide updated information on the pharmacological treatment of osteoporosis in the adult population. A comprehensive PubMed search was performed to review the current evidence on osteoporosis treatment. Of the 378 articles identified from the initial queries, the final review included 80 articles. Currently, the following pharmacological options are available: antiresorptive (bisphosphonates, denosumab, postmenopausal hormone replacement therapy and selective oestrogen receptor modulators), bone-forming agents (essentially, teriparatide and abaloparatide) and the new dual-action therapy (romosozumab), recently approved by the US Food and Drug Administration and the European Medicines Agency, but which is not yet an option in Portugal. Therapeutic selection is essentially based on assessment of cost-effectiveness, since current evidence does not suggest any differences between the distinctive classes in reducing the risk of fractures, but this analysis is limited by the scarcity of comparative intraclass studies. Notwithstanding, romosozumab, as a dual effect therapy, is promising in resolving the physiological limitations resulting from the merely unilateral action of antiresorptive agents and bone-forming agents in the inseparable relationship between bone formation and resorption. However, its cardiovascular safety raises some concerns, and this topic is still being debated. The underdiagnosis and the undertreatment of osteoporosis remain one of the greatest challenges of the 21st century. Over the years, new drugs have appeared that have tried to address these problems with a direct impact on the health of populations, but a long way remains to be come in optimising their effectiveness, safety and tolerability.
骨质疏松和脆性骨折是严重的公共卫生问题,严重影响个人健康和其他卫生服务的经济。药物治疗仍是临床干预的主要内容之一,并结合非药物措施预防脆性骨折的发生。在骨质疏松症的治疗中,有希望的新药理学选择的出现似乎更新了对预防并发症和随后降低发病率和死亡率的期望,包括对症治疗,改善身体功能和更好的生活质量。本综述旨在提供成人骨质疏松症药物治疗的最新信息。我们进行了全面的PubMed检索,以回顾目前骨质疏松症治疗的证据。在最初查询确定的378篇文章中,最终审查包括80篇文章。目前,有以下药物可供选择:抗骨吸收(双膦酸盐、denosumab、绝经后激素替代疗法和选择性雌激素受体调节剂)、成骨剂(主要是teriparatide和abaloparatide)和新的双作用疗法(romosozumab),该疗法最近已获得美国食品和药物管理局和欧洲药品管理局的批准,但尚未在葡萄牙上市。治疗方法的选择基本上是基于成本效益的评估,因为目前的证据并没有表明不同类别之间在降低骨折风险方面有任何差异,但这种分析受到类别内比较研究的缺乏的限制。尽管如此,romosozumab作为一种双效疗法,有望解决骨形成与骨吸收之间不可分割的关系中,抗骨吸收剂和骨形成剂仅单方作用所造成的生理限制。然而,它的心血管安全性引起了一些担忧,这个话题仍在争论中。骨质疏松症的诊断和治疗不足仍然是21世纪最大的挑战之一。多年来,出现了新的药物,试图解决这些问题,直接影响人口的健康,但在优化其有效性,安全性和耐受性方面还有很长的路要走。
{"title":"The Portuguese state of the art on osteoporosis and fracture risk: an update on the treatment options","authors":"Diogo Ramalho, Gustavo Melo Rocha, Maria João Oliveira","doi":"10.1055/a-2158-0872","DOIUrl":"https://doi.org/10.1055/a-2158-0872","url":null,"abstract":"Abstract Osteoporosis and fragility fractures are serious public health problems, which greatly impact individual health and the economy of other health services. Pharmacological treatment is still one of the main elements of clinical intervention, combined with non-pharmacological measures, in preventing the occurrence of fragility fractures. The emergence of promising new pharmacological options in the treatment of osteoporosis seems to renew expectations in the prevention of complications and a subsequent reduction in morbidity and mortality, including symptomatic treatment, improved physical function and a better quality of life. This review aims to provide updated information on the pharmacological treatment of osteoporosis in the adult population. A comprehensive PubMed search was performed to review the current evidence on osteoporosis treatment. Of the 378 articles identified from the initial queries, the final review included 80 articles. Currently, the following pharmacological options are available: antiresorptive (bisphosphonates, denosumab, postmenopausal hormone replacement therapy and selective oestrogen receptor modulators), bone-forming agents (essentially, teriparatide and abaloparatide) and the new dual-action therapy (romosozumab), recently approved by the US Food and Drug Administration and the European Medicines Agency, but which is not yet an option in Portugal. Therapeutic selection is essentially based on assessment of cost-effectiveness, since current evidence does not suggest any differences between the distinctive classes in reducing the risk of fractures, but this analysis is limited by the scarcity of comparative intraclass studies. Notwithstanding, romosozumab, as a dual effect therapy, is promising in resolving the physiological limitations resulting from the merely unilateral action of antiresorptive agents and bone-forming agents in the inseparable relationship between bone formation and resorption. However, its cardiovascular safety raises some concerns, and this topic is still being debated. The underdiagnosis and the undertreatment of osteoporosis remain one of the greatest challenges of the 21st century. Over the years, new drugs have appeared that have tried to address these problems with a direct impact on the health of populations, but a long way remains to be come in optimising their effectiveness, safety and tolerability.","PeriodicalId":50831,"journal":{"name":"Aktuelle Rheumatologie","volume":"9 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135266391","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evaluation Of The Relationship Of Kinesiophobia With Anxiety, Upper Extremity Disability And Quality Of Life In Patients With Frozen Shoulders 肩周炎患者运动恐惧症与焦虑、上肢残疾和生活质量的关系评价
4区 医学 Q4 RHEUMATOLOGY Pub Date : 2023-10-16 DOI: 10.1055/a-2154-8295
öznur Uysal Batmaz, Burkay Yakar, Tacettin Mirzaoğlu, Ahmet Yılmaz, Serda Em, Ibrahim Batmaz
Abstract Introduction Frozen shoulder is a painful shoulder disease in which glenohumeral joint movements are actively and passively restricted in all directions. If not treated, it can cause various psychological diseases and muscle and joint diseases. Kinesiophobia; this is defined as a fear of physical activity resulting from excessive sensitivity and an uncomfortable feeling due to painful or repeated injury. In this study, it was aimed to evaluate the relationship of kinesiophobia to upper extremity disability, anxiety and quality of life in patients with frozen shoulder. Materials and methods Fırat University Faculty of Medicine, Department of Physical Medicine and Rehabilitation, between September 2020 and March 2021; As a result of clinical evaluation and radiological examinations, patients were enrolled between the ages of 18–75 and who agreed to participate in the study; 48 patients were diagnosed with frozen shoulder and met the inclusion and exclusion criteria of the study and were included in the patient group; Fourty healthy subjects aged between 18–75 years, who did not have shoulder disease and who met the inclusion and exclusion criteria of the study, were included in the control group. A total of 88 cases were included in the study. The following scales were used. TAMPA kinesiophobia scale to assess kinesiophobia in patients and control group, Beck Anxiety scale to assess anxiety in patient group; The Disabilities of The Arm, Shoulder and Hand (DASH) scale to assess upper extremity disability; Short Form (SF)-36 was used to assess quality of life. Results TAMPA kinesiophobia scale was found to be significantly different in the patient group when the patient group and control group were compared. According to the correlation analysis, the TAMPA kinesiophobia scale showed a positive correlation with the Beck-Anxiety and DASH scales in the patient group, while a negative correlation was found with the SF36-Physical function, emotional role difficulty and social functionality. Conclusion In patients with frozen shoulder, kinesiophobia seems to be associated with increased anxiety and upper extremity disability, as well as low quality of life. Structural disorders as well as psychological factors should be taken into account among the reasons for the prolonged limitation of movement and delayed recovery. When the physicians serving in the primary care are experienced with patient management with frozen shoulder, as evaluated for therapeutic purposes, planning psychological support treatments in addition to medical and physical therapy will increase the quality of health care provided to patients.
摘要简介肩周炎是肩关节活动受到主动和被动全方位限制的一种疼痛性肩周炎。如不及时治疗,可引起各种心理疾病和肌肉、关节疾病。Kinesiophobia;这被定义为由于过度敏感和由于疼痛或反复受伤而产生的不舒服的感觉而对身体活动的恐惧。在本研究中,目的是评估运动恐惧症与冻结肩患者上肢残疾、焦虑和生活质量的关系。材料与方法Fırat大学医学院物理医学与康复系,2020年9月至2021年3月;根据临床评估和放射学检查结果,年龄在18-75岁之间并同意参加研究的患者被纳入研究;48例诊断为肩周炎且符合本研究纳入和排除标准的患者纳入患者组;40名年龄在18-75岁之间、没有肩部疾病且符合研究纳入和排除标准的健康受试者被纳入对照组。研究共纳入88例病例。使用了以下量表:坦帕运动恐惧症量表用于评估患者和对照组的运动恐惧症,贝克焦虑量表用于评估患者组的焦虑;臂肩手残疾量表(DASH)评价上肢残疾使用SF -36评估生活质量。结果将患者组与对照组进行比较,发现患者组的坦帕运动恐惧症量表存在显著差异。相关性分析显示,坦帕运动恐惧症量表与患者组Beck-Anxiety、DASH量表呈正相关,与SF36-Physical function、emotional role difficulty、social function呈负相关。结论在肩周炎患者中,运动恐惧症似乎与焦虑增加、上肢残疾以及生活质量低下有关。结构障碍和心理因素应考虑到长期限制运动和延迟恢复的原因。如果在初级保健服务的医生在管理肩周炎患者方面经验丰富,并根据治疗目的进行评估,那么除了医疗和物理治疗之外,规划心理支持治疗将提高向患者提供的保健质量。
{"title":"Evaluation Of The Relationship Of Kinesiophobia With Anxiety, Upper Extremity Disability And Quality Of Life In Patients With Frozen Shoulders","authors":"öznur Uysal Batmaz, Burkay Yakar, Tacettin Mirzaoğlu, Ahmet Yılmaz, Serda Em, Ibrahim Batmaz","doi":"10.1055/a-2154-8295","DOIUrl":"https://doi.org/10.1055/a-2154-8295","url":null,"abstract":"Abstract Introduction Frozen shoulder is a painful shoulder disease in which glenohumeral joint movements are actively and passively restricted in all directions. If not treated, it can cause various psychological diseases and muscle and joint diseases. Kinesiophobia; this is defined as a fear of physical activity resulting from excessive sensitivity and an uncomfortable feeling due to painful or repeated injury. In this study, it was aimed to evaluate the relationship of kinesiophobia to upper extremity disability, anxiety and quality of life in patients with frozen shoulder. Materials and methods Fırat University Faculty of Medicine, Department of Physical Medicine and Rehabilitation, between September 2020 and March 2021; As a result of clinical evaluation and radiological examinations, patients were enrolled between the ages of 18–75 and who agreed to participate in the study; 48 patients were diagnosed with frozen shoulder and met the inclusion and exclusion criteria of the study and were included in the patient group; Fourty healthy subjects aged between 18–75 years, who did not have shoulder disease and who met the inclusion and exclusion criteria of the study, were included in the control group. A total of 88 cases were included in the study. The following scales were used. TAMPA kinesiophobia scale to assess kinesiophobia in patients and control group, Beck Anxiety scale to assess anxiety in patient group; The Disabilities of The Arm, Shoulder and Hand (DASH) scale to assess upper extremity disability; Short Form (SF)-36 was used to assess quality of life. Results TAMPA kinesiophobia scale was found to be significantly different in the patient group when the patient group and control group were compared. According to the correlation analysis, the TAMPA kinesiophobia scale showed a positive correlation with the Beck-Anxiety and DASH scales in the patient group, while a negative correlation was found with the SF36-Physical function, emotional role difficulty and social functionality. Conclusion In patients with frozen shoulder, kinesiophobia seems to be associated with increased anxiety and upper extremity disability, as well as low quality of life. Structural disorders as well as psychological factors should be taken into account among the reasons for the prolonged limitation of movement and delayed recovery. When the physicians serving in the primary care are experienced with patient management with frozen shoulder, as evaluated for therapeutic purposes, planning psychological support treatments in addition to medical and physical therapy will increase the quality of health care provided to patients.","PeriodicalId":50831,"journal":{"name":"Aktuelle Rheumatologie","volume":"28 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136142325","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
Aktuelle Rheumatologie
全部 Acc. Chem. Res. ACS Applied Bio Materials ACS Appl. Electron. Mater. ACS Appl. Energy Mater. ACS Appl. Mater. Interfaces ACS Appl. Nano Mater. ACS Appl. Polym. Mater. ACS BIOMATER-SCI ENG ACS Catal. ACS Cent. Sci. ACS Chem. Biol. ACS Chemical Health & Safety ACS Chem. Neurosci. ACS Comb. Sci. ACS Earth Space Chem. ACS Energy Lett. ACS Infect. Dis. ACS Macro Lett. ACS Mater. Lett. ACS Med. Chem. Lett. ACS Nano ACS Omega ACS Photonics ACS Sens. ACS Sustainable Chem. Eng. ACS Synth. Biol. Anal. Chem. BIOCHEMISTRY-US Bioconjugate Chem. BIOMACROMOLECULES Chem. Res. Toxicol. Chem. Rev. Chem. Mater. CRYST GROWTH DES ENERG FUEL Environ. Sci. Technol. Environ. Sci. Technol. Lett. Eur. J. Inorg. Chem. IND ENG CHEM RES Inorg. Chem. J. Agric. Food. Chem. J. Chem. Eng. Data J. Chem. Educ. J. Chem. Inf. Model. J. Chem. Theory Comput. J. Med. Chem. J. Nat. Prod. J PROTEOME RES J. Am. Chem. Soc. LANGMUIR MACROMOLECULES Mol. Pharmaceutics Nano Lett. Org. Lett. ORG PROCESS RES DEV ORGANOMETALLICS J. Org. Chem. J. Phys. Chem. J. Phys. Chem. A J. Phys. Chem. B J. Phys. Chem. C J. Phys. Chem. Lett. Analyst Anal. Methods Biomater. Sci. Catal. Sci. Technol. Chem. Commun. Chem. Soc. Rev. CHEM EDUC RES PRACT CRYSTENGCOMM Dalton Trans. Energy Environ. Sci. ENVIRON SCI-NANO ENVIRON SCI-PROC IMP ENVIRON SCI-WAT RES Faraday Discuss. Food Funct. Green Chem. Inorg. Chem. Front. Integr. Biol. J. Anal. At. Spectrom. J. Mater. Chem. A J. Mater. Chem. B J. Mater. Chem. C Lab Chip Mater. Chem. Front. Mater. Horiz. MEDCHEMCOMM Metallomics Mol. Biosyst. Mol. Syst. Des. Eng. Nanoscale Nanoscale Horiz. Nat. Prod. Rep. New J. Chem. Org. Biomol. Chem. Org. Chem. Front. PHOTOCH PHOTOBIO SCI PCCP Polym. Chem.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1