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Electroacupuncture Pre-treatment Exerts an Anti-apoptotic Effect in Cerebral Ischaemia and Reperfusion Injury in Rats 电针预处理对大鼠脑缺血再灌注损伤的抗凋亡作用
IF 0.3 4区 医学 Q4 INTEGRATIVE & COMPLEMENTARY MEDICINE Pub Date : 2021-01-01 DOI: 10.3727/036012921x16237619666067
Zhu Luwen, Ye Tao, Tang Qiang, Yan Wang, Liao Hongyu, Liang Biying, Zhang Jiyao, Liang Runyu
Background: Electroacupuncture (EA) pre-treatment can play a significant neuroprotective role in rats with cerebral ischaemia and reperfusion (CIR) injury, but the specific mechanism needs to be further elucidated. Objective: To investigate the effects of EA pre-treatment on apoptosis-related proteins Bax, Bcl-2, Cytochrome c (cyt c), cleaved caspase-9 and -3 in rats with CIR injury. Methods: CIR injury was induced using middle cerebral artery occlusion (MCAO) ischaemia-reperfusion. Thirty-six male Specific Pathogen Free (SPF) Sprague-Dawley rats were randomly divided into three groups: Sham (n=12), MCAO (n=12), and the EA+MCAO group (n=12). EA+MCAO group rats received electroacupuncture at DU20 for 2 consecutive weeks before MCAO model preparation. After 24 h of reperfusion, neurological deficits were evaluated by modified neurological severity scores. Brain infarct volumes were examined by 2,3,5-triphenyltetrazolium chloride staining. Expression of Bax, Bcl-2, cyt c, cleaved caspase-9 and -3 in the ischaemic penumbra were detected by Western blotting, and apoptosis evaluated by TUNEL staining. Results: After perfusion for 24 h, compared with the MCAO group, the neurological deficit scores and brain infarct volumes in the EA+MCAO group were significantly decreased (P <0.05), as was the level of Bax (P <0.05) or the Bax/Bcl-2 ratio (P <0.05), levels of cyt c, cleaved caspase-9 and -3 also decreased (P <0.05), like the number of TUNEL-positive cells (P <0.05), in contrast, the level of Bcl-2. Conclusion: EA pre-treatment exerts an anti-apoptotic effect through Bax-to-Bcl-2 ratio downregulation, blockage of mitochondrial cyt c release to the cytosol, and reduction of caspase-9 and -3 expression in rats with CIR injury.
背景:电针(EA)预处理对脑缺血再灌注(CIR)损伤大鼠具有显著的神经保护作用,但具体机制有待进一步阐明。目的:探讨EA预处理对大鼠CIR损伤后凋亡相关蛋白Bax、Bcl-2、细胞色素c (cyt c)、cleaved caspase-9和-3的影响。方法:采用大脑中动脉闭塞(MCAO)缺血再灌注法诱导CIR损伤。选取雄性SPF大鼠36只,随机分为Sham组(n=12)、MCAO组(n=12)和EA+MCAO组(n=12)。EA+MCAO组大鼠在MCAO模型制备前连续2周在DU20处进行电针治疗。再灌注24小时后,采用改良的神经功能严重程度评分评估神经功能缺损。脑梗死体积采用2,3,5-三苯四唑氯染色法检测。Western blot检测缺血半暗区Bax、Bcl-2、cyt - c、cleaved caspase-9、-3的表达,TUNEL染色检测细胞凋亡。结果:灌注24 h后,与MCAO组比较,EA+MCAO组神经功能缺损评分、脑梗死体积显著降低(P <0.05), Bax水平(P <0.05)或Bax/Bcl-2比值(P <0.05),细胞c、cleaved caspase-9、-3水平下降(P <0.05), tunel阳性细胞数下降(P <0.05), Bcl-2水平下降(P <0.05)。结论:EA预处理通过下调Bax-to-Bcl-2比值,阻断线粒体cyt - c向细胞质释放,降低caspase-9和-3的表达,对CIR损伤大鼠具有抗凋亡作用。
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引用次数: 1
Clinical Application of Scalp Cluster Needling Combined with Bobath Technique in Upper Limb Spastic Paralysis After Stroke of Vertebral Artery Type 头皮束针联合Bobath技术治疗椎动脉型脑卒中后上肢痉挛性瘫痪的临床应用
IF 0.3 4区 医学 Q4 INTEGRATIVE & COMPLEMENTARY MEDICINE Pub Date : 2021-01-01 DOI: 10.3727/036012921x16287835103417
Zhiquan Wu, Mengjie Zeng, Aimin Gong
To observe the difference in clinical effects of scalp-point cluster acupuncture combined with rehabilitation training in treating spastic paralysis of upper limbs after stroke. Using a randomized controlled design, 96 patients with upper limb spastic paralysis after stroke were randomly divided into two groups: treatment group (scalp acupuncture plus rehabilitation training group 48 cases), control group (rehabilitation training group 48 cases). After 2 courses of treatment, it was judged by observing clinical efficacy evaluation, Ashworth classification, and Fugl-Meyer (FMA) score. The total effective rate was 91.7% in the treatment group and 68.7% in the control group; the difference between the two groups was statistically significant (P <0.05). Before treatment, the difference in Ashworth classification between the two groups was not statistically significant (P> 0.05); after treatment, the difference between the two groups was statistically significant (P <0.01). After treatment, the difference between the two groups was statistically significant (P<0.05). The Fugl-Meyer (FMA) scores of the two groups of patients before treatment were comparable (P>0.05), and there were significant differences between the two groups after treatment (P <0.05). The difference of Fugl-Meyer (FMA) scores between the two groups was statistically significant (P < 0.01). Scalp cluster acupuncture therapy is more effective than traditional acupuncture therapy alone in treating vertebral artery type cervical spondylosis. Scalp cluster acupuncture combined with Bobath technique is effective in treating spastic paralysis of upper limbs after stroke, and it is worthy of clinical application.
观察头穴丛针配合康复训练治疗脑卒中后上肢痉挛性麻痹的临床疗效差异。采用随机对照设计,将96例脑卒中后上肢痉挛性瘫痪患者随机分为两组:治疗组(头皮针刺加康复训练组48例)、对照组(康复训练组48例)。治疗2个疗程后,通过观察临床疗效评价、Ashworth分级、Fugl-Meyer (FMA)评分进行判断。治疗组总有效率91.7%,对照组总有效率68.7%;两组间差异有统计学意义(p0.05);治疗后两组比较差异有统计学意义(P <0.05),治疗后两组比较差异有统计学意义(P <0.05)。两组患者Fugl-Meyer (FMA)评分差异有统计学意义(P < 0.01)。头皮丛针治疗椎动脉型颈椎病比单纯针刺治疗效果更好。头皮丛针配合波浴法治疗脑卒中后上肢痉挛性麻痹疗效显著,值得临床推广应用。
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引用次数: 0
Therapeutic Effect of Changqiang Acupoint Injection on Children with Functional Fecal Incontinence 长强穴位注射治疗小儿功能性大便失禁的疗效观察
IF 0.3 4区 医学 Q4 INTEGRATIVE & COMPLEMENTARY MEDICINE Pub Date : 2021-01-01 DOI: 10.3727/036012921x16298112109466
Changying Yi, J Zhang, M. Fan
Objective: Functional fecal incontinence in children (FFIC), also known as functional fecal disorder in children, is a type of childhood diseases characterized by excretory dysfunction. In the study, we observed the clinical effect of Changqiang acupoint injection on functional fecal incontinence in children (FFIC) by randomized controlled clinical trials. Materials and methods: 140 children with functional fecal incontinence who met the screening criteria were respectively assigned into the treatment group (100 cases) and the control group (40 cases) according to the completely randomized controlled design. In the treatment group, Chuankezhi injection was administrated at the Changqiang acupoint once a week for three weeks (one course of treatment). In contrast, the subjects in the control group was instructed to receive sphincter exercise and defecation training, followed by an assessment on the therapeutic efficacy after one course of treatment. Results: The overall response rate of the two groups was 93.00% (93/100) and 57.50% (23/40), respectively, with a statistically significant difference (P<0.01). The treatment group showed a performance superior to the control group based on the Cleveland Clinic Florida Fecal Incontinence Score System (CCF-FI)—dry stool incontinence, liquid incontinence, gas incontinence, lifestyle change, necessity of using pads or antidiarrheals, the ability to delay defecation, and the total score. The inter-group comparison revealed a statistically significant difference (P<0.01). Conclusion:Changqiang acupoint injection has significant curative effect on FFIC as demonstrated by significant relief in the symptoms associated with fecal incontinence, and thus is considered as a useful approach to be widely applied in clinical practice.
目的:儿童功能性大便失禁(Functional fecal incontinence in children, FFIC),又称儿童功能性大便障碍,是一种以排泄功能障碍为特征的儿童期疾病。本研究通过随机对照临床试验,观察长强穴位注射治疗儿童功能性大便失禁(FFIC)的临床疗效。材料与方法:140例符合筛查标准的功能性大便失禁患儿按完全随机对照设计分为治疗组(100例)和对照组(40例)。治疗组给予传可治注射液于长强穴,每周1次,连用3周(1个疗程)。对照组接受括约肌运动和排便训练,一个疗程后评估治疗效果。结果:两组患者总有效率分别为93.00%(93/100)、57.50%(23/40),差异有统计学意义(P<0.01)。根据克利夫兰诊所佛罗里达粪便失禁评分系统(CCF-FI),治疗组表现优于对照组,包括干性大便失禁、液体失禁、气体失禁、生活方式改变、使用垫或止泻药的必要性、延迟排便的能力和总分。组间比较,差异有统计学意义(P<0.01)。结论:长强穴位注射治疗FFIC疗效显著,可明显缓解大便失禁相关症状,是一种可广泛应用于临床的有效方法。
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引用次数: 0
Electroacupuncture Inhibits Inflammatory Response in Rats With Interstitial Cystitis 电针抑制间质性膀胱炎大鼠炎症反应
IF 0.3 4区 医学 Q4 INTEGRATIVE & COMPLEMENTARY MEDICINE Pub Date : 2021-01-01 DOI: 10.3727/036012921x16258618048412
Ji-wei Feng, Wen Li, Jiandang Liu, Junsheng Hu, Zhi-hao Li, Xuehui Zhao, Yue-Lai Chen
OBJECTIVE: Electroacupuncture (EA) has been clinically utilized to manage interstitial cystitis (IC), but its related mechanism research is remained to be researched. This study aimed to explore the role of EA in inhibiting the inflammatory response of IC rats, and research the possible mechanism based on the changes of urodynamics, mast cell tryptase expression and the content of inflammatory substances. METHODS: EA (continuous wave, 30 Hz, 1 mA) was applied to stimulate the Ciliao point (BL32) and the Huiyang point (BL35) of rats. Changes of urodynamics, mast cell tryptase expression and the content of IL-6 and TNF-α were detected after 24 hours of the treatment. RESULTS: The results showed that after EA treatment, compared with the model group, the initial urination time of the rats was prolonged (3.23 ± 0.60 to 5.27 ± 0.27 min), the bladder capacity was increased (0.80 ± 0.15 to 1.31 ± 0.07 ml), and the degree of bladder mucosal damage was restored. The expression of mast cell tryptase, and the content of IL-6 and TNF-α in its bladder tissue and urine were reduced.CONCLUSION: These findings suggested that EA could suppress bladder overactivity and inhibit inflammatory response of IC rats, and its mechanism was proved to be related to the inhibition of mast cell degranulation and the down-regulation of inflammatory substances IL-6 and TNF-α in bladder tissue.
目的:电针(EA)治疗间质性膀胱炎(IC)已被临床应用,但其相关机制尚待研究。本研究旨在探讨EA对IC大鼠炎症反应的抑制作用,并从尿动力学、肥大细胞胰蛋白酶表达及炎症物质含量的变化等方面探讨其可能的机制。方法:用EA(连续波,30 Hz, 1 mA)刺激大鼠睫状肌点(BL32)和回阳点(BL35)。治疗24 h后检测尿动力学、肥大细胞胰蛋白酶表达及IL-6、TNF-α含量的变化。结果:与模型组比较,EA治疗后大鼠初尿时间延长(3.23±0.60 ~ 5.27±0.27 min),膀胱容量增加(0.80±0.15 ~ 1.31±0.07 ml),膀胱黏膜损伤程度恢复。膀胱组织和尿液中肥大细胞胰蛋白酶表达降低,IL-6、TNF-α含量降低。结论:EA可抑制IC大鼠膀胱过度活动,抑制炎症反应,其机制可能与抑制膀胱肥大细胞脱颗粒、下调膀胱组织炎性物质IL-6、TNF-α有关。
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引用次数: 0
Analysis of HRV and Body Temperature Variation for Manual Acupuncture and PEMF (Pulsed Electro-Magnetic Field) Acupuncture Stimulation 手针和脉冲电磁场刺激下HRV和体温变化分析
IF 0.3 4区 医学 Q4 INTEGRATIVE & COMPLEMENTARY MEDICINE Pub Date : 2021-01-01 DOI: 10.3727/036012921x16287835103390
Ja-Woo Lee, Jun-Young Kim, Jaeho Hyun, Yong-Heum Lee
Objective: The purpose of this study is to evaluate the clinical therapeutic effectiveness and applicability of the PEMF (pulsed electro-magnetic field) acupuncture. To verify this, we observe autonomic nervous system (ANS; such as the HRV and body temperature) variation for the manual acupuncture and the PEMF acupuncture. Method: 56 voluntary participants were divided into three groups; non-stimulation group, manual acupuncture group (MAG), and PEMF acupuncture group (PAG). BL15 (Bladder Meridian) was selected as the stimulation area, the PEMF parameters were chosen at 2 Hz and 46mT. The HRV and body temperature were measured before and after each stimulation. The HRV at low frequency (LF; 0.04 - 0.15 Hz) and high frequency (HF; 0.15 - 0.4 Hz) were analyzed to acquire LF/HF ratio. Results: The LF and the LF/HF ratio were found to be lower in the MAG (p = 0.026) and the PAG (p = 0.011), but higher in the non-stimulation group (p = 0.778). The HF was found to be higher in the MAG (p = 0.011) and the PAG (p = 0.013). In BL15, the non-stimulation group had very low body temperature variation. The temperature difference in the MAG before and after the procedure was 0.37°C; there were no significant differences (p = 0.114). The temperature difference in the PAG was larger than that for the MAG, at 0.83°C; it was a significant difference (p = 0.001). Conclusion: We found that the manual acupuncture and the PEMF acupuncture at BL15 activated the parasympathetic nervous system. Therefore, we confirm that the PEMF acupuncture can be expected to have a similar effect as acupuncture and can be applied as a means of clinical acupuncture treatment
目的:评价脉冲电磁场针刺的临床疗效和适用性。为了验证这一点,我们观察了自主神经系统(ANS;如HRV和体温)的变化对于手动针灸和脉冲电场针灸。方法:56名志愿者分为三组;无刺激组、手针刺组(MAG)、PEMF针刺组(PAG)。选择BL15(膀胱经络)作为刺激区域,选择2 Hz、46mT的PEMF参数。在每次刺激前后分别测量HRV和体温。低频HRV (LF;0.04 - 0.15 Hz)和高频(HF;0.15 ~ 0.4 Hz),得到低频/高频比。结果:MAG组和PAG组的LF和LF/HF比值较低(p = 0.026), PAG组较低(p = 0.011),而非刺激组较低(p = 0.778)。HF在MAG (p = 0.011)和PAG (p = 0.013)中较高。在BL15中,非刺激组的体温变化非常低。手术前后MAG温差为0.37℃;差异无统计学意义(p = 0.114)。PAG的温差大于MAG,为0.83℃;差异有统计学意义(p = 0.001)。结论:我们发现手针刺和脉冲电场针刺在BL15处激活了副交感神经系统。因此,我们确认,PEMF针灸可以预期具有与针灸相似的效果,可以作为临床针灸治疗的一种手段
{"title":"Analysis of HRV and Body Temperature Variation for Manual Acupuncture and PEMF (Pulsed Electro-Magnetic Field) Acupuncture Stimulation","authors":"Ja-Woo Lee, Jun-Young Kim, Jaeho Hyun, Yong-Heum Lee","doi":"10.3727/036012921x16287835103390","DOIUrl":"https://doi.org/10.3727/036012921x16287835103390","url":null,"abstract":"Objective: The purpose of this study is to evaluate the clinical therapeutic effectiveness and applicability of the PEMF (pulsed electro-magnetic field) acupuncture. To verify this, we observe autonomic nervous system (ANS; such as the HRV and body temperature) variation for the manual acupuncture and the PEMF acupuncture. Method: 56 voluntary participants were divided into three groups; non-stimulation group, manual acupuncture group (MAG), and PEMF acupuncture group (PAG). BL15 (Bladder Meridian) was selected as the stimulation area, the PEMF parameters were chosen at 2 Hz and 46mT. The HRV and body temperature were measured before and after each stimulation. The HRV at low frequency (LF; 0.04 - 0.15 Hz) and high frequency (HF; 0.15 - 0.4 Hz) were analyzed to acquire LF/HF ratio. Results: The LF and the LF/HF ratio were found to be lower in the MAG (p = 0.026) and the PAG (p = 0.011), but higher in the non-stimulation group (p = 0.778). The HF was found to be higher in the MAG (p = 0.011) and the PAG (p = 0.013). In BL15, the non-stimulation group had very low body temperature variation. The temperature difference in the MAG before and after the procedure was 0.37°C; there were no significant differences (p = 0.114). The temperature difference in the PAG was larger than that for the MAG, at 0.83°C; it was a significant difference (p = 0.001). Conclusion: We found that the manual acupuncture and the PEMF acupuncture at BL15 activated the parasympathetic nervous system. Therefore, we confirm that the PEMF acupuncture can be expected to have a similar effect as acupuncture and can be applied as a means of clinical acupuncture treatment","PeriodicalId":50881,"journal":{"name":"Acupuncture & Electro-Therapeutics Research","volume":"1 1","pages":""},"PeriodicalIF":0.3,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69699248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Correlation Between Ion Contents in Acupuncture Points and Propagated Sensation a long with Channel 穴位离子含量与经络传播感觉的相关性研究
IF 0.3 4区 医学 Q4 INTEGRATIVE & COMPLEMENTARY MEDICINE Pub Date : 2021-01-01 DOI: 10.3727/036012921x16304136917636
Fu-Shin Lee, Tai-An Chiang, Jou Ying Lee, Chen-I Lin
Background: Propagated sensation along with channels are phenomena that occur because of stimulations during acupuncture therapies and tend to transmit the stimulating signals along the meridians. From the Western medicine aspect, researchers consider the phenomena as neurotransmissions initiated by nerves, and various ions regulate the physiological functions of the nervous systems.Objective: The object of this research is to investigate the key characteristics of ions at acupoints and the mechanism of propagated sensation along with channels, which are crossing meridians in traditional Chinese medicine (TCM).Methods: This research first conduct experiments by applying intense pulse light beams, which replace the traditional acupuncture treatments, on designated acupoints of studied human subjects, and employ a thermal infrared imager to monitor the temperature responses, which are induced by post sensation, in adjacent regions of the acupoints. Meanwhile, the research applies a synchrotron radiation technique on adult SD (Sprague Dawley) rats, and the study analyses the output responses with an X-ray Absorption Fine Spectroscopy (XAFS) to investigate the ion distributions in the relevant acupoints, which might trigger the propagated sensation crossing meridians.Results: Experimental results demonstrate that significant temperature increases simultaneously at the stimulated acupoints and certain other acupoints, whether in the same meridians. Moreover, XAFS experimental results indicate significantly high levels of calcium, potassium, and sulfide ions at the stimulated acupoint regions. On the contrary, the measured chloride ions level at the regions is correspondingly lower.Conclusions: The thermal infrared imager monitoring show significant temperature variations of crossing-meridian acupoints after implementing the intense pulse light beams on designated acupoints, and it implies the occurring of prolonged sensation along with channels using acupuncture therapies. The x-ray absorption spectrum demonstrates significant differences in ion amounts and distributions between the acupoints and non-acupoints, and acupuncture therapies result in ion concentrations in the correlated regions inducing propagated sensation crossing meridians in TCM. Hence, the stimulated acupoints operate as ion reservoirs to provide high-concentration of specific ions to trigger the crossing-meridian post sensation.
背景:感觉随经络传播是针刺治疗过程中由于刺激而产生的现象,刺激信号倾向于沿经络传递。从西医角度来看,研究者认为这种现象是由神经引发的神经传递,各种离子调节神经系统的生理功能。目的:本研究的目的是探讨中医经络交叉的腧穴离子的主要特征及感觉随经络传播的机制。方法:本研究首先采用替代传统针灸疗法的强脉冲光束照射被研究对象的指定穴位进行实验,并利用热红外成像仪监测穴位邻近区域由后感引起的温度反应。同时,采用同步辐射技术对成年SD (Sprague Dawley)大鼠进行实验,利用x射线吸收精细光谱(XAFS)对输出响应进行分析,研究相关穴位中离子的分布情况,这些离子可能引发经络传播的感觉。结果:实验结果表明,无论是在同一经络中,受刺激的穴位和某些其他穴位的温度同时显著升高。此外,XAFS实验结果表明,在受刺激的穴位区域,钙、钾和硫化物离子水平显著升高。相反,测得的区域氯离子水平相对较低。结论:热红外成像监测显示,在指定穴位上施加强脉冲光束后,经络交叉穴位的温度发生了显著变化,提示针刺疗法可能出现感觉随经络延长的现象。x射线吸收光谱显示,穴位与非穴位之间离子的数量和分布存在显著差异,针灸治疗导致相关区域的离子浓度升高,从而引起中医经络传播感。因此,受刺激的穴位作为离子储藏库,提供高浓度的特定离子,触发穿越经络后的感觉。
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引用次数: 0
Acupuncture Treatment of Non-inflammatory Chronic Prostatitis with 针刺治疗慢性非炎症性前列腺炎
IF 0.3 4区 医学 Q4 INTEGRATIVE & COMPLEMENTARY MEDICINE Pub Date : 2021-01-01 DOI: 10.3727/036012921x16304136917609
Zhang Aj, Y. He, F. Chen, H. Chen, B. Jiang, Zhang Gy, L. Guo, Shields Lh, Nielsen Lp
Objective: To compare the clinical efficacy of "Tiao Shen Jie Yu" acupuncture, conventional acupuncture, and tamsulosin to treat non-inflammatory chronic prostatitis (type IIIB CP). Methods: 105 patients were randomly divided into the "Tiao Shen Jie Yu" acupuncture group, conventional acupuncture group, and tamsulosin group, 35 cases in each group. In the "Tiao Shen Jie Yu" acupuncture group, PC6 (Neiguan), PC7 (Daling), HT7 (Shenmen), RN6 (Qihai), RN4 (Guanyuan), ST28 (Shuidao), ST36 (Zusanli), SP9 (Yinlingquan), SP6 (Sanyinjiao), and LR3 (Taichong) were selected; In the conventional acupuncture group, RN4 (Guanyuan), RN3 (Zhongji), KI3 (Taixi), SP6 (Sanyinjiao), BL54 (Zhibian) through ST28 (Shuidao), BL20 (Pishu), and BL23 (Shenshu) were set. Acupuncture was given once every other day, 30 minutes each time, three times a week, 12 times in a row as a course of treatment. Tamsulosin group took tamsulosin 0.2mg orally, once a day for four weeks. The three groups were observed for two methods. The NIH-CPSI total score, NIH-CPSI pain symptom score, Hamilton Depression Scale (HAMD) score, and Hamilton Anxiety Scale (HAMA) score were compared among the three groups. After one course of treatment and after two methods of treatment, and the recurrence rate and clinical efficacy were evaluated. Results: The NIH-CPSI total score, NIH-CPSI pain symptom score, HAMD and HAMA scores of the three groups after one course of treatment and two courses of treatment were lower than those before treatment (all P<0.01). After one course of treatment and two courses of treatment, the total NIH-CPSI score, NIH-CPSI pain score, HAMD, and HAMA score in the "Tiao Shen Jie Yu" acupuncture group decreased more than those in the conventional acupuncture group and tamsulosin group (all P<0.05). The recurrence rate of the "Tiao Shen Jie Yu" acupuncture group was lower than that of the conventional acupuncture group and tamsulosin group, and the difference was statistically significant (P<0.05). The total effective rates of the conventional acupuncture group and tamsulosin group were 78.13% (25/32) and 69.70% (23/33), respectively, which were lower than 97.06% (33/34) of the "Tiao Shen Jie Yu" acupuncture group. No severe adverse reactions occurred in the safety evaluation.Conclusion: The therapeutic effect of "Tiao Shen Jie Yu" Acupuncture on type III BCP is better than that of conventional acupuncture and tamsulosin, and it is better than that of traditional acupuncture and tamsulosin in relieving prostatitis symptoms, anxiety, and depression.
目的:比较调肾解郁针刺、常规针刺、坦索罗辛治疗非炎症性慢性前列腺炎(IIIB型CP)的临床疗效。方法:105例患者随机分为调肾解郁针刺组、常规针刺组和坦索罗辛组,每组35例。“调肾解郁”针刺组选择PC6(内关)、PC7(大陵)、HT7(神门)、RN6(七海)、RN4(观园)、ST28(水岛)、ST36(足三里)、SP9(银灵泉)、SP6(三阴角)、LR3(太中);常规针刺组设置RN4(观源)、RN3(中基)、KI3(太溪)、SP6(三阴交)、BL54(直边)至ST28(水岛)、BL20(脾俞)、BL23(肾俞)。每隔一天针灸1次,每次30分钟,每周3次,连续12次为1个疗程。坦索罗辛组患者口服坦索罗辛0.2mg,每日1次,连用4周。三组采用两种方法进行观察。比较三组患者的NIH-CPSI总分、NIH-CPSI疼痛症状评分、汉密尔顿抑郁量表(HAMD)评分和汉密尔顿焦虑量表(HAMA)评分。观察1个疗程及2种治疗方法后的复发率及临床疗效。结果:三组患者治疗1个疗程和2个疗程后的NIH-CPSI总分、NIH-CPSI疼痛症状评分、HAMD、HAMA评分均低于治疗前(均P<0.01)。经1个疗程和2个疗程治疗后,调参解俞针刺组患者的NIH-CPSI总分、NIH-CPSI疼痛评分、HAMD、HAMA评分下降幅度均大于常规针刺组和坦索罗辛组(均P<0.05)。调肾解郁针刺组复发率低于常规针刺组和坦索罗辛组,差异有统计学意义(P<0.05)。常规针刺组和坦索罗辛组的总有效率分别为78.13%(25/32)和69.70%(23/33),均低于调神解郁针刺组的97.06%(33/34)。安全性评价中未发生严重不良反应。结论:调肾解郁针刺治疗III型BCP的疗效优于常规针刺加坦索罗辛,在缓解前列腺炎症状、焦虑、抑郁方面优于传统针刺加坦索罗辛。
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引用次数: 0
Topical Ethanol Therapy for Human Papillomavirus in Atheroma 局部乙醇治疗人乳头瘤病毒在动脉粥样硬化中的作用
IF 0.3 4区 医学 Q4 INTEGRATIVE & COMPLEMENTARY MEDICINE Pub Date : 2021-01-01 DOI: 10.3727/036012921x16264625521763
Etsuo Murata, K. Tokita, S. Tsurusaki, Hidetaka Murata
We have developed ethanol therapy for infectious atheroma based on the experience of two cases in which ethanol was injected into the liver cyst and the cyst shrank. For 64 infectious atheromas, atheroma contents were excreted and the cyst wall was contacted with 76% ethanol gauze for 5 minutes. Postoperatively, the cyst was washed daily as an open drainage. All cases were cured 10 days postoperatively, and no side effects. Postoperative follow up study results in 36 cases showed no recurrence in an average of 5 years. Pathological examination revealed koilocytosis in 14 of 25 cases (56%), which is considered to be an in direct finding of viral infection. The changes in human papillomavirus (HPV 16) before and after ethanol therapy in 25 cases using the Bi Digital O Ring Test (BDORT) decreased significantly from 10 26 ng (BDORT units) preoperatively to 1.6 ng (BDORT units) postoperatively. In also 12 cases follow up study without microscopy HPV 16 same decreased from 1064ng to 1.2 ng (BDORT unit) using BDORT with atheroma photographs. In total, HPV 16 could be demonstrated in 37 of 64 cases (57.8%) using BDOR T. Temporal changes of HPV 16 used for BDORT in 7 cases after contact with ethanol were inactivated after 3 minutes 30 seconds. The involvement of HPV 16 is suggested as the cause of atheroma. It is speculated that ethanol inactivated HPV 16 of atheroma, which stopped the turnover of the squamous epithelium and prevented recurrence. Ethanol therapy for infectious atheroma is useful as an original new one stage surgery because it is a simple procedure and has no side effects or recurrence.
我们开发了乙醇治疗感染性动脉粥样硬化基于两个案例的经验,其中乙醇被注射到肝囊肿和囊肿缩小。64例感染性动脉粥样硬化,排出动脉粥样硬化内容物,用76%乙醇纱布接触囊壁5分钟。术后,囊肿每天清洗,开放引流。术后10天全部治愈,无不良反应。术后随访36例,平均5年无复发。病理检查发现25例患者中有14例(56%)出现白细胞增多症,这被认为是病毒感染的直接发现。25例使用Bi数字O环试验(BDORT)的人乳头瘤病毒(HPV 16)在乙醇治疗前后的变化从术前的1026 ng (BDORT单位)下降到术后的1.6 ng (BDORT单位)。在12例无镜检的随访研究中,使用BDORT和动脉粥样硬化照片,HPV 16从1064ng下降到1.2 ng (BDORT单位)。64例患者中,37例(57.8%)通过BDOR t检测到hpv16,其中7例与乙醇接触后,hpv16的时间变化在3分30秒后失活。HPV 16的参与被认为是导致动脉粥样硬化的原因。推测乙醇灭活了动脉粥样硬化的HPV 16,从而阻止了鳞状上皮的更新,防止了复发。乙醇治疗感染性动脉粥样硬化是一种新的一期手术,因为它是一个简单的过程,没有副作用或复发。
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引用次数: 0
Electro-Acupuncture Combined Methadone for Withdrawal Symptoms of Opioid Addiction: A Protocol for Systematic Review and Meta-Analysis 电针联合美沙酮治疗阿片类药物成瘾戒断症状:一个系统回顾和荟萃分析的方案
IF 0.3 4区 医学 Q4 INTEGRATIVE & COMPLEMENTARY MEDICINE Pub Date : 2021-01-01 DOI: 10.3727/036012921x16237619666094
Tianyao Zhang, Xiaoyan He, Lijuan Wu, Xianrong Feng, Yu Yang, Lu Deng
Background Opioid addiction is a chronic brain disorder characterized by a series of withdrawal symptoms in behavioral, psychological, and neurobiological manifestations. Withdrawal symptoms are the main cause of relapse after periods of abstinence; thus, the treatment is focused on abstinence symptoms. Due to most of all types of opioid agonist drugs carry a potential for addiction and exacerbation of withdrawal symptoms, nondrug methods have great potentials in clinical applications. Electro-acupuncture (EA), as a novel nonpharmacological approach, combined with methadone has a long-term positive efficacy on treating addiction. Therefore, we designed a protocol to evaluate the adjuvant effect of EA for treating withdrawal symptoms of opioid addiction. Method To review reports of relevant clinical trials, we will search English language databases (EMBASE, PubMed, and the Cochrane Central Register of Controlled Trials) and Chinese databases (Chinese Biomedical Literatures, China National Knowledge Infrastructure, Wanfang, and VIP). We will collect documents from the earliest possible date up to May 2020. We will also search online trial registries such as ClinicalTrials. gov (ClinicalTrials.gov/), the European Medicine Agency (www.ema.europa.eu/ema/), and WHO International Clinical Trials Registry Platform (www.who.int/ictrp). We will select randomized controlled trials (RCT) for withdrawal from opioid addiction involving EA-methadone and methadone alone treatment. We will use psychological assessment scales to evaluate treatment major outcomes which include numerous components such as OWS, VAS, HAMD, HAMA; then urinalysis and methadone dosage also will be measure as the additional outcomes. Finally, RevMan5 software will be used for literature quality evaluation and data analysis. Result: To evaluate the efficacy of EA in combination therapy by observing the outcomes of corresponding scale, urinalysis and decreasing methadone. Conclusion: This protocol will be used to evaluate the efficacy and safety of EA in combination with methadone in treatment of opioid addiction withdrawal symptoms. Abbreviations: Opioid dependence, OWS=Opiate Withdrawal Scale, VAS=Craving Visual Analog Scale, PWSS=Post-withdrawal symptoms Scale, HAMD=Hamilton Depression Scale, HAMA=Hamilton Anxiety Scale, RCTs=Randomized Controlled Trials, EA=Electrical Acupuncture, PRISMA=Preferred Reporting Items for Systematic Reviews and Meta-Analyses.
阿片类药物成瘾是一种以行为、心理和神经生物学表现为特征的一系列戒断症状为特征的慢性脑部疾病。戒断症状是戒断期后复发的主要原因;因此,治疗的重点是禁欲症状。由于大多数类型的阿片受体激动剂药物具有成瘾性和加重戒断症状的可能性,因此非药物方法在临床应用中具有很大的潜力。电针作为一种新型的非药物治疗方法,联合美沙酮治疗成瘾具有长期的积极疗效。因此,我们设计了一个方案来评估EA治疗阿片类药物成瘾戒断症状的辅助作用。方法检索英文数据库(EMBASE、PubMed、Cochrane中央对照试验注册库)和中文数据库(中国生物医学文献、中国知库、万方、维普),对相关临床试验报告进行检索。我们将在2020年5月之前尽可能早地收集文件。我们还将搜索在线试验注册,如ClinicalTrials。gov (ClinicalTrials.gov/),)、欧洲医药管理局(www.ema.europa.eu/ema/)和世卫组织国际临床试验注册平台(www.who.int/ictrp)。我们将选择包括ea美沙酮和美沙酮单独治疗的阿片类药物成瘾戒断的随机对照试验(RCT)。我们将使用心理评估量表来评估治疗主要结果,包括许多组成部分,如OWS、VAS、HAMD、HAMA;然后尿液分析和美沙酮剂量也将作为附加结果进行测量。最后使用RevMan5软件进行文献质量评价和数据分析。结果:通过观察相应量表、尿液分析及减少美沙酮的结果,评价EA在联合治疗中的疗效。结论:本方案将用于评价EA联合美沙酮治疗阿片类药物成瘾戒断症状的有效性和安全性。缩写:阿片类药物依赖,OWS=阿片类药物戒断量表,VAS=渴望视觉模拟量表,PWSS=戒断后症状量表,HAMD=汉密尔顿抑郁量表,HAMA=汉密尔顿焦虑量表,rct =随机对照试验,EA=电针,PRISMA=系统评价和荟萃分析的首选报告项目。
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引用次数: 1
Warming Acupuncture in the Treatment of Cervical Spondylotic Radiculopathy: A Systematic Review and Meta-analysis 温针治疗神经根型颈椎病:系统综述和荟萃分析
IF 0.3 4区 医学 Q4 INTEGRATIVE & COMPLEMENTARY MEDICINE Pub Date : 2021-01-01 DOI: 10.3727/036012921x16273277361795
Wang Zuqing, Li Yan
Background: Warming acupuncture (WA) is widely used in the management of Cervical spondylotic radiculopathy (CSR)in China and obtains desirable efficacy. Therefore, the aim of this study is to systematically assess the efficacy and safety whether using WA alone or combined with traditional Chinese medicine (TCM) therapy for the treatment of CSR. Methods: PubMed, EMBASE, Sinomed, the Cochrane Library, CNKI, VIP and Wangfang databases were searched from their inception through 30 September 2020. All the retrieved records were screened or excluded based on the criteria that were pre-established, and the results that meet the criteria were assessed by the Cochrane risk of bias tool and Meta-analysis was conducted by using RevMan5.3 software. Results: Fourteen RCTs (1021patients) were included in the meta-analysis. The effective rate of WA alone or combination with TCM therapy was analyzed in comparison with the treatment of regular therapy. The results indicated that compared with regular therapy, WA alone or in combination with TCM therapy increased clinical effective rate (Odds ratio (OR)=4.43,95%CI 2.85 to 6.90, P<0.01). Additionally decreased VAS score (mean difference (MD)=-1.21,95%CI -1.68 to -0.73, P<0.01), PPI (MD=-1.34, 95% CI -2.08 to -0.61) and PRI (MD=-0.55,95% CI -0.72 to -0.37, P<0.001). However, adverse events of WA were not specially reported in all studies. Conclusions: WA as the main treatment for CSR can improve the clinical effective rate and reduce the level of VAS score, PPI and PRI. Further research is needed to determine the effectiveness of WA for CSR treatment, rigorously and unambiguously.
背景:温针治疗神经根型颈椎病在国内被广泛应用,并取得了良好的疗效。因此,本研究的目的是系统评估WA单独或联合中药治疗CSR的疗效和安全性。方法:检索PubMed、EMBASE、Sinomed、Cochrane Library、CNKI、VIP和Wangfang数据库自建站至2020年9月30日的数据库。根据预先设定的标准筛选或排除所有检索到的记录,使用Cochrane偏倚风险工具评估符合标准的结果,使用RevMan5.3软件进行meta分析。结果:14项随机对照试验(1021例患者)纳入meta分析。比较常规治疗与单用或联合中药治疗的有效率。结果显示,与常规治疗相比,WA单用或联合中药治疗均能提高临床有效率(优势比(or)=4.43,95%CI 2.85 ~ 6.90, P<0.01)。此外,VAS评分(平均差异(MD)=-1.21,95%CI -1.68 ~ -0.73, P<0.01)、PPI (MD=-1.34, 95%CI -2.08 ~ -0.61)和PRI (MD=-0.55,95% CI -0.72 ~ -0.37, P<0.001)也降低。然而,并不是所有的研究都特别报道了WA的不良事件。结论:WA作为CSR的主要治疗方法,可以提高临床有效率,降低VAS评分、PPI、PRI水平,需要进一步的研究来严格、明确地确定WA治疗CSR的有效性。
{"title":"Warming Acupuncture in the Treatment of Cervical Spondylotic Radiculopathy: A Systematic Review and Meta-analysis","authors":"Wang Zuqing, Li Yan","doi":"10.3727/036012921x16273277361795","DOIUrl":"https://doi.org/10.3727/036012921x16273277361795","url":null,"abstract":"Background: Warming acupuncture (WA) is widely used in the management of Cervical spondylotic radiculopathy (CSR)in China and obtains desirable efficacy. Therefore, the aim of this study is to systematically assess the efficacy and safety whether using WA alone or combined with traditional Chinese medicine (TCM) therapy for the treatment of CSR. Methods: PubMed, EMBASE, Sinomed, the Cochrane Library, CNKI, VIP and Wangfang databases were searched from their inception through 30 September 2020. All the retrieved records were screened or excluded based on the criteria that were pre-established, and the results that meet the criteria were assessed by the Cochrane risk of bias tool and Meta-analysis was conducted by using RevMan5.3 software. Results: Fourteen RCTs (1021patients) were included in the meta-analysis. The effective rate of WA alone or combination with TCM therapy was analyzed in comparison with the treatment of regular therapy. The results indicated that compared with regular therapy, WA alone or in combination with TCM therapy increased clinical effective rate (Odds ratio (OR)=4.43,95%CI 2.85 to 6.90, P<0.01). Additionally decreased VAS score (mean difference (MD)=-1.21,95%CI -1.68 to -0.73, P<0.01), PPI (MD=-1.34, 95% CI -2.08 to -0.61) and PRI (MD=-0.55,95% CI -0.72 to -0.37, P<0.001). However, adverse events of WA were not specially reported in all studies. Conclusions: WA as the main treatment for CSR can improve the clinical effective rate and reduce the level of VAS score, PPI and PRI. Further research is needed to determine the effectiveness of WA for CSR treatment, rigorously and unambiguously.","PeriodicalId":50881,"journal":{"name":"Acupuncture & Electro-Therapeutics Research","volume":"65 1","pages":""},"PeriodicalIF":0.3,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69699049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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Acupuncture & Electro-Therapeutics Research
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