首页 > 最新文献

Acupuncture & Electro-Therapeutics Research最新文献

英文 中文
Vaccine against gastrin, a polyclonal antibody stimulator, decreases pancreatic cancer metastases. 多克隆抗体刺激物胃泌素疫苗可减少胰腺癌转移。
IF 4.5 4区 医学 Q4 INTEGRATIVE & COMPLEMENTARY MEDICINE Pub Date : 2019-11-01 Epub Date: 2019-08-21 DOI: 10.1152/ajpgi.00145.2019
Nicholas Osborne, Rebecca Sundseth, Martha D Gay, Hong Cao, Robin D Tucker, Sandeep Nadella, Shangzi Wang, Xunxian Liu, Alexander Kroemer, Lynda Sutton, Allen Cato, Jill P Smith

Growth of pancreatic cancer is stimulated by gastrin in both a paracrine and an autocrine fashion. Traditional therapies have not significantly improved survival, and recently pancreatic cancer has been deemed a "cold" tumor due to its poor response to immunotherapy. Strategies to improve survival of pancreatic cancer are desperately needed. In the current investigation, we studied the effects of an anti-gastrin cancer vaccine, polyclonal antibody stimulator (PAS; formerly called G17DT and Gastrimmune), used alone or in combination with a programmed cell death receptor (PD)-1 immune checkpoint antibody on pancreatic cancer growth, metastases, and the tumor microenvironment (TME). Immune-competent female C57BL/6 mice bearing syngeneic orthotopic murine pancreatic cancer treated with PAS had significantly smaller tumors and fewer metastases. Examination of the TME demonstrated decreased fibrosis with fewer M2 and more M1 tumor-associated macrophages. Expression of the E-cadherin gene was significantly increased and expression of the TGFβR2 gene was decreased compared with controls. Mice treated with PAS or the combination of PAS and PD-1 antibody exhibited significantly less tumor expression of phospho-paxillin, the focal adhesion protein β-catenin, and matrix metalloproteinase-7. This study suggests that inhibition of the cancer-promoting effects of gastrin in pancreatic cancer can decrease metastases by altering the TME and decreasing pathways that activate the epithelial mesenchymal transition. The PAS vaccine appears to change the TME, making it more susceptible to therapy with an immune checkpoint antibody. This novel combination of two immunotherapies may improve survival of pancreatic cancer by decreasing both tumor growth and metastasis formation.NEW & NOTEWORTHY Survival from advanced pancreatic cancer is poor, in part due to dense fibrosis of the tumor microenvironment, increased number of M2-polarized macrophages that promote angiogenesis and invasion, and lack of "target-specific" therapy. Herein, we report that a tumor vaccine that selectively targets gastrin decreases pancreatic cancer growth and metastases. Furthermore, the gastrin vaccine polyclonal antibody stimulator alters the tumor microenvironment rendering it more responsive to immunotherapy with a programmed cell death receptor-1 immune checkpoint antibody.

胃泌素以旁分泌和自分泌两种方式刺激胰腺癌生长。传统疗法并没有明显改善患者的生存状况,最近,由于胰腺癌对免疫疗法的反应不佳,它被认为是一种 "冷 "肿瘤。改善胰腺癌生存率的策略亟待制定。在目前的研究中,我们研究了抗胃蛋白酶癌症疫苗--多克隆抗体刺激物(PAS;以前称为 G17DT 和 Gastrimmune)单独使用或与程序性细胞死亡受体(PD)-1 免疫检查点抗体联合使用对胰腺癌生长、转移和肿瘤微环境(TME)的影响。免疫功能正常的雌性 C57BL/6 小鼠在接受 PAS 治疗后,肿瘤明显缩小,转移灶明显减少。对肿瘤组织的检查显示,纤维化程度降低,M2肿瘤相关巨噬细胞减少,M1肿瘤相关巨噬细胞增加。与对照组相比,E-cadherin 基因的表达明显增加,TGFβR2 基因的表达减少。用 PAS 或 PAS 与 PD-1 抗体联合治疗的小鼠,其肿瘤中磷酸-paxillin、局灶粘附蛋白 β-catenin、基质金属蛋白酶-7 的表达明显减少。这项研究表明,抑制胃泌素在胰腺癌中的促癌作用可以通过改变TME和减少激活上皮间质转化的途径来减少转移。PAS疫苗似乎能改变TME,使其更容易接受免疫检查点抗体的治疗。这种两种免疫疗法的新型组合可通过减少肿瘤生长和转移的形成来提高胰腺癌的生存率。晚期胰腺癌的生存率很低,部分原因是肿瘤微环境致密纤维化、促进血管生成和侵袭的 M2 极化巨噬细胞数量增加以及缺乏 "靶向特异性 "疗法。在此,我们报告了一种选择性靶向胃泌素的肿瘤疫苗可减少胰腺癌的生长和转移。此外,胃泌素疫苗多克隆抗体刺激物可改变肿瘤微环境,使其对程序性细胞死亡受体-1免疫检查点抗体的免疫疗法更敏感。
{"title":"Vaccine against gastrin, a polyclonal antibody stimulator, decreases pancreatic cancer metastases.","authors":"Nicholas Osborne, Rebecca Sundseth, Martha D Gay, Hong Cao, Robin D Tucker, Sandeep Nadella, Shangzi Wang, Xunxian Liu, Alexander Kroemer, Lynda Sutton, Allen Cato, Jill P Smith","doi":"10.1152/ajpgi.00145.2019","DOIUrl":"10.1152/ajpgi.00145.2019","url":null,"abstract":"<p><p>Growth of pancreatic cancer is stimulated by gastrin in both a paracrine and an autocrine fashion. Traditional therapies have not significantly improved survival, and recently pancreatic cancer has been deemed a \"cold\" tumor due to its poor response to immunotherapy. Strategies to improve survival of pancreatic cancer are desperately needed. In the current investigation, we studied the effects of an anti-gastrin cancer vaccine, polyclonal antibody stimulator (PAS; formerly called G17DT and Gastrimmune), used alone or in combination with a programmed cell death receptor (PD)-1 immune checkpoint antibody on pancreatic cancer growth, metastases, and the tumor microenvironment (TME). Immune-competent female C57BL/6 mice bearing syngeneic orthotopic murine pancreatic cancer treated with PAS had significantly smaller tumors and fewer metastases. Examination of the TME demonstrated decreased fibrosis with fewer M2 and more M1 tumor-associated macrophages. Expression of the <i>E-cadherin</i> gene was significantly increased and expression of the <i>TGFβR2</i> gene was decreased compared with controls. Mice treated with PAS or the combination of PAS and PD-1 antibody exhibited significantly less tumor expression of phospho-paxillin, the focal adhesion protein β-catenin, and matrix metalloproteinase-7. This study suggests that inhibition of the cancer-promoting effects of gastrin in pancreatic cancer can decrease metastases by altering the TME and decreasing pathways that activate the epithelial mesenchymal transition. The PAS vaccine appears to change the TME, making it more susceptible to therapy with an immune checkpoint antibody. This novel combination of two immunotherapies may improve survival of pancreatic cancer by decreasing both tumor growth and metastasis formation.<b>NEW & NOTEWORTHY</b> Survival from advanced pancreatic cancer is poor, in part due to dense fibrosis of the tumor microenvironment, increased number of M2-polarized macrophages that promote angiogenesis and invasion, and lack of \"target-specific\" therapy. Herein, we report that a tumor vaccine that selectively targets gastrin decreases pancreatic cancer growth and metastases. Furthermore, the gastrin vaccine polyclonal antibody stimulator alters the tumor microenvironment rendering it more responsive to immunotherapy with a programmed cell death receptor-1 immune checkpoint antibody.</p>","PeriodicalId":50881,"journal":{"name":"Acupuncture & Electro-Therapeutics Research","volume":"1 1","pages":"G682-G693"},"PeriodicalIF":4.5,"publicationDate":"2019-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6879893/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79701693","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Multimodal Impact of Acupuncture, Exercise Therapy, And Concurrent Functional Electrical Stimulation On Osteoarthritis of the Knee: a Case Report 针灸、运动疗法和并发功能电刺激对膝关节骨关节炎的多模式影响:一例报告
IF 0.3 4区 医学 Q4 INTEGRATIVE & COMPLEMENTARY MEDICINE Pub Date : 2019-09-20 DOI: 10.3727/036012919x15650315071942
L. Ingle, A. Hakakzadeh, V. Moradi, Roshanak Honarpishe, P. Noormohammadpour, N. N. Ansari
Knee osteoarthritis (OA) causes functional limitation in weight-bearing actlVltles including walking. To investigate the multimodal impact of acupuncture, exercise therapy, and concurrent functional electrical stimulation (FES) on knee osteoarthritis. We designed a multidisciplinary treatment package including acupuncture; home based exercise therapy, and concurrent functional electrical stimulation during treadmill walking. Outcomes measurements included the numerical rating scale (NRS), the Knee Injury and Osteoarthritis Outcome Score (KOOS), and the Tampa Scale of Kinesiophobia (TSK). Measurements were completed at baseline and following the treatment phase which consisted of six individual sessions. A 48-year-old male, office worker presented with a history of chronic right knee. During the previous year, he was diagnosed with knee osteoarthritis after clinical physical examination by a sports medicine physician. Following our novel training intervention, the patient reported a reduction in pain intensity from 8 to 2 on the NRS, improved in all KOOS subscale scores, and improved in the TSK scale (reduction from 15 to 11). In addition, the patient reported that he was able to return to work and undertake normal activities of daily living with reduced knee pain. This case report showed that our novel multimodal intervention including six sessions of acupuncture, exercise therapy, and treadmill walking with functional electrical stimulation (FES) had a positive impact on knee pain and function in a middle-aged male with knee osteoarthritis.
膝关节骨关节炎(OA)导致负重活动的功能限制,包括行走。探讨针刺、运动疗法和并发功能电刺激(FES)对膝关节骨关节炎的多模式影响。我们设计了一个多学科治疗方案,包括针灸;以家庭为基础的运动疗法,以及在跑步机上行走时同时进行的功能性电刺激。结果测量包括数值评定量表(NRS)、膝关节损伤和骨关节炎结局评分(oos)和坦帕运动恐惧症量表(TSK)。测量在基线和治疗阶段完成,治疗阶段包括6个单独的疗程。48岁男性,办公室职员,慢性右膝病史。在过去的一年里,他在运动医学医生的临床体检后被诊断患有膝关节骨关节炎。在我们的新训练干预后,患者报告疼痛强度从NRS的8分降低到2分,所有oos子量表得分都有所改善,TSK量表得分也有所改善(从15分降低到11分)。此外,患者报告称他能够重返工作岗位并进行正常的日常生活活动,膝关节疼痛减轻。本病例报告显示,我们的新型多模式干预包括六个疗程的针灸,运动疗法和跑步机行走功能电刺激(FES),对患有膝关节骨关节炎的中年男性膝关节疼痛和功能有积极的影响。
{"title":"Multimodal Impact of Acupuncture, Exercise Therapy, And Concurrent Functional Electrical Stimulation On Osteoarthritis of the Knee: a Case Report","authors":"L. Ingle, A. Hakakzadeh, V. Moradi, Roshanak Honarpishe, P. Noormohammadpour, N. N. Ansari","doi":"10.3727/036012919x15650315071942","DOIUrl":"https://doi.org/10.3727/036012919x15650315071942","url":null,"abstract":"Knee osteoarthritis (OA) causes functional limitation in weight-bearing actlVltles including walking. To investigate the multimodal impact of acupuncture, exercise therapy, and concurrent functional electrical stimulation (FES) on knee osteoarthritis. We designed a multidisciplinary\u0000 treatment package including acupuncture; home based exercise therapy, and concurrent functional electrical stimulation during treadmill walking. Outcomes measurements included the numerical rating scale (NRS), the Knee Injury and Osteoarthritis Outcome Score (KOOS), and the Tampa Scale of\u0000 Kinesiophobia (TSK). Measurements were completed at baseline and following the treatment phase which consisted of six individual sessions. A 48-year-old male, office worker presented with a history of chronic right knee. During the previous year, he was diagnosed with knee osteoarthritis after\u0000 clinical physical examination by a sports medicine physician. Following our novel training intervention, the patient reported a reduction in pain intensity from 8 to 2 on the NRS, improved in all KOOS subscale scores, and improved in the TSK scale (reduction from 15 to 11). In addition, the\u0000 patient reported that he was able to return to work and undertake normal activities of daily living with reduced knee pain. This case report showed that our novel multimodal intervention including six sessions of acupuncture, exercise therapy, and treadmill walking with functional electrical\u0000 stimulation (FES) had a positive impact on knee pain and function in a middle-aged male with knee osteoarthritis.","PeriodicalId":50881,"journal":{"name":"Acupuncture & Electro-Therapeutics Research","volume":" ","pages":""},"PeriodicalIF":0.3,"publicationDate":"2019-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43812906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
The beneficial effect of electro acupuncture on obesity may be associated with irisin, nesfatin-l and preptin levels 电针对肥胖的有益作用可能与鸢尾素、nesfatin- 1和preptin水平有关
IF 0.3 4区 医学 Q4 INTEGRATIVE & COMPLEMENTARY MEDICINE Pub Date : 2019-06-01 DOI: 10.3727/036012919x15650315071924
Z. Ercan, Gulnihal Deniz, F. Caf, S. Algul, Abdullah Gazioglu, A. Kavaklı
The action mechanism of acupuncture, one of the alternative methods used in obesity treatment, is unknown. The purpose of this study was to investigate the effect of electro acupuncture on weight loss and whether acupuncture treatment can change circulating levels of irisin, nesfatin-l and preptin, which have been discovered in recent years and plays an important role in nutrition and energy metabolism. Irisin, a newly discovered myokine, is associated with increased energy consumption and has a potential role in obesity. Preptin, present in islet b-cells of pancreas and associated with the carbohydrate metabolism, nesfatin1 is an anorexogenic peptide composed of 82 amino acids and regulates food intake by modulating neuropeptides in feeding centers in the brain. These three new hormones regulate energy intake and expenditure and preserve energy homeostasis and composition. In this study 4 weeks old Sprague Dawley male rats (n=16) were randomly divided into 2 groups which were the control (C): normal diet and obese (0): high fat diet (HFD) groups. 105 After 16 weeks which obesity was developed, electroacupuncture (EA) was performed to rats once in every second days for 3 times weekly for four consecutive weeks. EA was applied bilaterally to Zusanli (ST36), Bai Hui (Du20), He Gu (Li4), Tianshu (ST25) and Sanyinjiao (SP6) acupoints in animals to both groups. Blood was collected before and after EA and serum irisin, nesfatin-l and preptin levels were analyzed by ELISA (Enzyme-InducedImmunosorbent Analysis) method. After four week EA treatment, there was sginificant decrease of the average body weight in both groups rats. There were increases in the serum nesfatin-l and preptin levels in the both groups after acupuncture. A decrease was observed in the irisin levels in obese group, but an increase in the control group. These findings suggest that electroacupuncture may help to weight loss due to its effects on some important metabolic hormones such as irisin, nesfatin-l and preptin only for a few weeks. It is thought that the changes of these hormones levels may playa role in beneficial effect of acupuncture used in the treatment of human obesity. The application of EA in the treatment of obesity is very effective, which may have led to weight loss by altering these hormone levels in obese people.
针灸是治疗肥胖的替代方法之一,其作用机制尚不清楚。本研究的目的是研究电针对减肥的影响,以及针灸治疗是否能改变近年来发现的在营养和能量代谢中起重要作用的鸢尾素、内脂素-1和前素的循环水平。Irisin是一种新发现的肌细胞因子,与能量消耗增加有关,在肥胖中有潜在作用。nesfatin1存在于胰腺的胰岛b细胞中,与碳水化合物代谢有关,是一种由82个氨基酸组成的厌食肽,通过调节大脑进食中心的神经肽来调节食物摄入。这三种新激素调节能量的摄入和消耗,并保持能量的稳态和组成。本研究将4周龄Sprague-Dawley雄性大鼠(n=16)随机分为2组,即对照组(C):正常饮食组和肥胖组(0):高脂肪饮食组。105肥胖16周后,大鼠每2天电针1次,每周3次,连续4周。电针应用于动物足三里(ST36)、白回(Du20)、合谷(Li4)、天枢(ST25)和三阴交(SP6)穴位。采用酶联免疫吸附分析法(ELISA)测定电针前后大鼠血清鸢尾素、内脂素-1和预处理素水平。电针治疗4周后,两组大鼠的平均体重均显著下降。针刺后两组血清nesfatin-1和prepin水平均升高。在肥胖组中观察到鸢尾素水平下降,但在对照组中则有所上升。这些发现表明,电针可能有助于减肥,因为它只对一些重要的代谢激素如鸢尾素、内脂素-1和preptin产生几周的影响。人们认为,这些激素水平的变化可能在针灸治疗人类肥胖的有益效果中发挥作用。EA在治疗肥胖中的应用是非常有效的,这可能通过改变肥胖者的这些激素水平而导致体重减轻。
{"title":"The beneficial effect of electro acupuncture on obesity may be associated with irisin, nesfatin-l and preptin levels","authors":"Z. Ercan, Gulnihal Deniz, F. Caf, S. Algul, Abdullah Gazioglu, A. Kavaklı","doi":"10.3727/036012919x15650315071924","DOIUrl":"https://doi.org/10.3727/036012919x15650315071924","url":null,"abstract":"The action mechanism of acupuncture, one of the alternative methods used in obesity treatment, is unknown. The purpose of this study was to investigate the effect of electro acupuncture on weight loss and whether acupuncture treatment can change circulating levels of irisin, nesfatin-l\u0000 and preptin, which have been discovered in recent years and plays an important role in nutrition and energy metabolism. Irisin, a newly discovered myokine, is associated with increased energy consumption and has a potential role in obesity. Preptin, present in islet b-cells of pancreas and\u0000 associated with the carbohydrate metabolism, nesfatin1 is an anorexogenic peptide composed of 82 amino acids and regulates food intake by modulating neuropeptides in feeding centers in the brain. These three new hormones regulate energy intake and expenditure and preserve energy homeostasis\u0000 and composition. In this study 4 weeks old Sprague Dawley male rats (n=16) were randomly divided into 2 groups which were the control (C): normal diet and obese (0): high fat diet (HFD) groups. 105 After 16 weeks which obesity was developed, electroacupuncture (EA) was performed to rats once\u0000 in every second days for 3 times weekly for four consecutive weeks. EA was applied bilaterally to Zusanli (ST36), Bai Hui (Du20), He Gu (Li4), Tianshu (ST25) and Sanyinjiao (SP6) acupoints in animals to both groups. Blood was collected before and after EA and serum irisin, nesfatin-l and preptin\u0000 levels were analyzed by ELISA (Enzyme-InducedImmunosorbent Analysis) method. After four week EA treatment, there was sginificant decrease of the average body weight in both groups rats. There were increases in the serum nesfatin-l and preptin levels in the both groups after acupuncture. A\u0000 decrease was observed in the irisin levels in obese group, but an increase in the control group. These findings suggest that electroacupuncture may help to weight loss due to its effects on some important metabolic hormones such as irisin, nesfatin-l and preptin only for a few weeks. It is\u0000 thought that the changes of these hormones levels may playa role in beneficial effect of acupuncture used in the treatment of human obesity. The application of EA in the treatment of obesity is very effective, which may have led to weight loss by altering these hormone levels in obese people.","PeriodicalId":50881,"journal":{"name":"Acupuncture & Electro-Therapeutics Research","volume":" ","pages":""},"PeriodicalIF":0.3,"publicationDate":"2019-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46758460","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Local mechanisms for acupoint sensitization in gall bladder meridian of foot shaoyang-a gene chip study 足少阳胆经穴位致敏局部机制的基因芯片研究
IF 0.3 4区 医学 Q4 INTEGRATIVE & COMPLEMENTARY MEDICINE Pub Date : 2019-06-01 DOI: 10.3727/036012919x15650315071898
K. Ishida, Liyue Qin, Ting Wang, Ying Lei, Weiwei Hu, Geng Zhu, Qian-qian Zhuang, Yan-ling Gong, Qian Wang, G. Arijit, Dong Ma, Xingwang Li, Sheng-tian Li
Acupuncture manipulations are clinically important to traditional Chinese medicine, yet the biological mechanisms have not been fully understood. This study aimed to investigate continuous stimulation-induced gene expression changes at stimulated and non-stimulated adjacent acupoints in the same meridian. Catgut embedding into acupoint (CEP) was conducted at acupoint Yanglingquan (gall bladder meridian of foot-shaoyang 34, GB34) of Sprague Dawley rats once or continuously for eight weeks, and gene expression changes at GB34 were assessed by gene chip array analysis 72 h after the last CEP treatment. A total of 688 genes exhibited opposite changes in expression between the two treatments, and 1,336 genes were regulated only by the eight-week CEP treatment. Ingenuity Pathway Analysis revealed that among these differentially regulated genes by one-time and eight-week CEP treatment, insulin-like growth factor-1 pathway and integrin-linked kinase pathway, and Wnt/~ catenin signaling pathway match the observed gene changes to predicted up/down regulation patterns. Upstream analysis further predicted six molecules, namely, tumor necrosis factor, interleukin 1~, interleukin la, kallikrein-related peptidase 5, protein kinase Ca, and catenin ~1. On the other hand, continuous eight-week CEP stimulation at acupoint Xuanzhong (GB39) caused similar changes in the expression of 32 genes at acupoints GB34 and Fengshi (GB31) on the same meridian. Taken together, our results provide the first molecular evidence for the local acupoints' mechanisms for acupoint sensitization theory, and implicate the existence of signaling pathways, either direct or indirect, between acupoints within the meridian GB.
针灸手法在中医临床上具有重要意义,但其生物学机制尚不完全清楚。本研究旨在研究连续刺激在同一经络中刺激和非刺激相邻穴位诱导的基因表达变化。在Sprague-Dawley大鼠的阳陵泉穴(足少阳34胆经,GB34)进行一次或连续8周的穴位埋线(CEP),并在最后一次CEP治疗后72小时通过基因芯片阵列分析评估GB34的基因表达变化。在两个处理之间,共有688个基因表现出相反的表达变化,1336个基因仅通过八周的CEP处理受到调节。独创性通路分析显示,在这些通过一次性和八周CEP治疗而受到差异调节的基因中,胰岛素样生长因子-1通路和整合素连接激酶通路以及Wnt/~连环蛋白信号通路与观察到的基因变化相匹配,以预测上调/下调模式。上游分析进一步预测了6种分子,即肿瘤坏死因子、白细胞介素1~、白细胞素la、激肽释放酶相关肽酶5、蛋白激酶Ca和连环蛋白~1。另一方面,连续8周的CEP刺激宣中穴(GB39)引起同一经穴GB34和风石穴(GB31)32个基因表达的相似变化。总之,我们的研究结果为穴位致敏理论的局部穴位机制提供了第一个分子证据,并暗示了GB经络内穴位之间存在直接或间接的信号通路。
{"title":"Local mechanisms for acupoint sensitization in gall bladder meridian of foot shaoyang-a gene chip study","authors":"K. Ishida, Liyue Qin, Ting Wang, Ying Lei, Weiwei Hu, Geng Zhu, Qian-qian Zhuang, Yan-ling Gong, Qian Wang, G. Arijit, Dong Ma, Xingwang Li, Sheng-tian Li","doi":"10.3727/036012919x15650315071898","DOIUrl":"https://doi.org/10.3727/036012919x15650315071898","url":null,"abstract":"Acupuncture manipulations are clinically important to traditional Chinese medicine, yet the biological mechanisms have not been fully understood. This study aimed to investigate continuous stimulation-induced gene expression changes at stimulated and non-stimulated adjacent acupoints\u0000 in the same meridian. Catgut embedding into acupoint (CEP) was conducted at acupoint Yanglingquan (gall bladder meridian of foot-shaoyang 34, GB34) of Sprague Dawley rats once or continuously for eight weeks, and gene expression changes at GB34 were assessed by gene chip array analysis 72\u0000 h after the last CEP treatment. A total of 688 genes exhibited opposite changes in expression between the two treatments, and 1,336 genes were regulated only by the eight-week CEP treatment. Ingenuity Pathway Analysis revealed that among these differentially regulated genes by one-time and\u0000 eight-week CEP treatment, insulin-like growth factor-1 pathway and integrin-linked kinase pathway, and Wnt/~ catenin signaling pathway match the observed gene changes to predicted up/down regulation patterns. Upstream analysis further predicted six molecules, namely, tumor necrosis factor,\u0000 interleukin 1~, interleukin la, kallikrein-related peptidase 5, protein kinase Ca, and catenin ~1. On the other hand, continuous eight-week CEP stimulation at acupoint Xuanzhong (GB39) caused similar changes in the expression of 32 genes at acupoints GB34 and Fengshi (GB31) on the same meridian.\u0000 Taken together, our results provide the first molecular evidence for the local acupoints' mechanisms for acupoint sensitization theory, and implicate the existence of signaling pathways, either direct or indirect, between acupoints within the meridian GB.","PeriodicalId":50881,"journal":{"name":"Acupuncture & Electro-Therapeutics Research","volume":" ","pages":""},"PeriodicalIF":0.3,"publicationDate":"2019-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46325316","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
A meta-analysis of the clinical efficacy of the combination of acupuncture and Chinese medicine in the treatment of haemorrhoids 针灸与中药结合治疗痔疮临床疗效的meta分析
IF 0.3 4区 医学 Q4 INTEGRATIVE & COMPLEMENTARY MEDICINE Pub Date : 2019-06-01 DOI: 10.3727/036012919x15650315071915
Mengjie Zeng, Xue-Hui Cheng, Geer Chen, Ji-you Kou
At present, surgical resection is the main method of the treatment of haemorrhoids, but is easy to recur after surgery. Recently, it is reported that acupuncture has a beneficial influence on haemorrhoids. Thus, whether acupuncture is effective in the treatment of haemorrhoids is the key in this meta-analysis. To evaluate the clinical efficacy of the treatment of combination of acupuncture and Chinese medicine in haemorrhoids by meta-analysis, which provide a scientific, effective and feasible evidence for clinical decision-making and practice. A systematic review and meta-analysis of randomized clinical trials (RCTs). A meta-analysis was performed by using Review Manager 5.3. All RCTs about combination of acupuncture and Chinese medicine versus Chinese medicine alone were selected and assessed for inclusion. The effective rate (ER), recurrence rate(RR), Symptom score before and after treatment (perianal edema, hemafecia, perianal pain, pruritus ani, prolapse of haemorrhoids) were the outcomes analyzed in this meta-analysis. II RCTs and 976 patients were included. The methodological quality of most included trials was low to moderate. In this meta-analysis, the clinical efficacy of combination of acupuncture and Chinese medicine was more effective than only Chinese medicine used in haemorrhoids. The effective rate [OR=5.24,95%CI(3.72,7.40), P
目前,手术切除是治疗痔疮的主要方法,但手术后容易复发。最近,有报道称针灸对痔疮有有益的影响。因此,针灸治疗痔疮是否有效是本荟萃分析的关键。通过荟萃分析,评价针灸与中药结合治疗痔疮的临床疗效,为临床决策和实践提供科学、有效、可行的依据。随机临床试验(rct)的系统回顾和荟萃分析。使用Review Manager 5.3进行meta分析。所有关于针灸和中药结合与单独使用中药的随机对照试验均被选择并评估纳入。有效率(ER)、复发率(RR)、治疗前后症状评分(肛周水肿、便血、肛周疼痛、瘙痒、痔疮脱垂)是本meta分析的结果。纳入2项随机对照试验和976例患者。大多数纳入的试验的方法学质量为低到中等。在本荟萃分析中,针灸与中药结合治疗痔疮的临床疗效比单纯使用中药更有效。有效率[OR=5.24,95%CI(3.72,7.40), P< 0.05]。,复发率[OR= 0。29日,95% ci (O。Ii, 0.73), p = 0。[009],肛周水肿[WMD=- 0.74,95%CI-O]。90 o。59岁的P < O。OOOOI],便血[大规模杀伤性武器= -O.78 ci-o 95%。89 to-O.67。P < O。[qh],肛周疼痛[WMD=- 0.72,95%CI-O]。94 o。50 P < O。WMD=- 0.75,95%CI-O。92 o。58岁的P < O。[qh]和痔疮脱垂[WMD=-0.43,95%CI-O]。84 o。02年,P = O。[04]在本荟萃分析中显示。(OR:优势比;CI:置信区间;WMD:加权平均差)。针灸结合中药治疗痔疮的临床有效率约为96%,单用中药治疗痔疮的临床有效率约为89%,明显表明实验组的疗效比对照组高7%。针灸与中医结合治疗痔疮比单纯中医治疗痔疮更有效,平均临床疗效达91%。
{"title":"A meta-analysis of the clinical efficacy of the combination of acupuncture and Chinese medicine in the treatment of haemorrhoids","authors":"Mengjie Zeng, Xue-Hui Cheng, Geer Chen, Ji-you Kou","doi":"10.3727/036012919x15650315071915","DOIUrl":"https://doi.org/10.3727/036012919x15650315071915","url":null,"abstract":"At present, surgical resection is the main method of the treatment of haemorrhoids, but is easy to recur after surgery. Recently, it is reported that acupuncture has a beneficial influence on haemorrhoids. Thus, whether acupuncture is effective in the treatment of haemorrhoids is the\u0000 key in this meta-analysis. To evaluate the clinical efficacy of the treatment of combination of acupuncture and Chinese medicine in haemorrhoids by meta-analysis, which provide a scientific, effective and feasible evidence for clinical decision-making and practice. A systematic review and\u0000 meta-analysis of randomized clinical trials (RCTs). A meta-analysis was performed by using Review Manager 5.3. All RCTs about combination of acupuncture and Chinese medicine versus Chinese medicine alone were selected and assessed for inclusion. The effective rate (ER), recurrence rate(RR),\u0000 Symptom score before and after treatment (perianal edema, hemafecia, perianal pain, pruritus ani, prolapse of haemorrhoids) were the outcomes analyzed in this meta-analysis. II RCTs and 976 patients were included. The methodological quality of most included trials was low to moderate. In this\u0000 meta-analysis, the clinical efficacy of combination of acupuncture and Chinese medicine was more effective than only Chinese medicine used in haemorrhoids. The effective rate [OR=5.24,95%CI(3.72,7.40), P<O. OOOOI], recurrence rate [OR=O.29, 95%CI(O. II, O.73), P=O.009], perianal edema [WMD=-O.74,95%CI-O.90\u0000 to-O.59, P<O. OOOOI], hemafecia[WMD=-O.78,95%CI-O.89 to-O.67. P<O. OOOOI], perianal pain[WMD=-O.72,95%CI-O.94 to-O.50, P<O. OOOOI], pruritus ani[WMD=-O.75,95%CI-O.92 to-O.58, P<O. OOOOI] and prolapse of haemorrhoids[WMD=-0.43,95%CI-O.84 to-O.02, P=O.04] were shown in this meta-analysis.(OR:odds\u0000 ratio;CI:confidence interval;WMD: weighted mean difference). There was about 96% of the clinical efficiency in the treatment of acupuncture plus Chinese medicine in haemorrhoids and 89% of that used in Chinese medicine alone, which indicates clearly that 7% higher efficiency in the experimental\u0000 group compared with the control group. The treatment of combination of acupuncture and Chinese medicine in haemorrhoids is more useful than Chinese medicine alone applied in piles, which is shown in 91% of clinical effects in average.","PeriodicalId":50881,"journal":{"name":"Acupuncture & Electro-Therapeutics Research","volume":" ","pages":""},"PeriodicalIF":0.3,"publicationDate":"2019-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46877961","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Neuroacustica®'s Sound Stimulation Effects over Neurotransmitters, Cortisol, P-Amyloid (1-42), Thromboxane B2 and Telomere, on Cerebral Pons Representative Area, on the back of the head, and other Abnormal Body Locations, Using Bi-Digital O-Ring Test. 使用双数字O型环测试,Neuroacustica®对神经递质、皮质醇、P-淀粉样蛋白(1-42)、血栓素B2和端粒、脑积水代表区、后脑勺和其他异常身体部位的声音刺激效果。
IF 0.3 4区 医学 Q4 INTEGRATIVE & COMPLEMENTARY MEDICINE Pub Date : 2019-06-01 DOI: 10.3727/036012919x15675460598319
L. H. Uno, Marcelo P. de Paula, S. Iwasa, W. Falzoni, M. H. Tanaka, L. Alves, F. Barros, T. Higashi, Lair Ribeiro
Thirty patients with marked depletion of neurotransmitters concentrations were noninvasively evaluated by Bi-Digital O-Ring Test (an electro-magnetic field (EMF) resonance phenomenon between two identical substances and amount1 ,2,3). Reference Control Substances (RCS) of Serotonin, Acetylcholine, Dopamine, Cortisol, ~-Amyloid, Thromboxane B2, and Telomere were measured over cerebral pons representative area and any other abnormal region presented, before and after submitted to Neuroacustica® (a 60 minutes sound treatment). The results are as follow. The average Serotonin on cerebral pons was 1.25 before and 150.33 mcg after (p
通过双数字O型环测试(两种相同物质和量之间的电磁场(EMF)共振现象1,2,3)对30名神经递质浓度显著降低的患者进行了无创评估。在接受Neuroacustica®(60分钟声音治疗)治疗前后,在脑桥代表性区域和任何其他异常区域测量血清素、乙酰胆碱、多巴胺、皮质醇、~-淀粉样蛋白、血栓素B2和端粒的对照物质(RCS)。结果如下。脑桥上的平均血清素在术前为1.25和术后为150.33 mcg(p<O.OOl*),异常区在术前和术后分别为12.91和142.73 mcg(p=O.003*),异常区的多巴胺含量分别为2.23和156.20 mcg(p<O.OOl*),异常区为8.06和158.09 mcg(p=O.003*),脑桥上的~淀粉样蛋白在异常区为17.33和4.30ng(p=O.OOl*),异常区为10.78和4.86ng(p<0.128),异常区前和异常区后的平均端粒数分别为1037.83和23.82ng(p=0.033*)。脑桥前和异常后的平均端粒酶数分别为46.08和375.18ng(p<O.OOl*),异常区前为56.50和异常后为446.25ng(p=0.012*)。另外五名处于相同条件(大脑神经递质水平低)的患者接受了相同的手术,这次进行了24小时的随访。总之,听力Neuroacustica®-Part 1曾经具有良好的生理作用,充分增加了正常细胞的端粒、血清素、乙酰胆碱、多巴胺;脑桥和异常区的血栓素B2、皮质醇、~淀粉样体和癌症细胞端粒均明显降低。这种影响可能会持续约24小时。对EMF的阐述,某种食物和酒精可能会抵消它的好处。
{"title":"Neuroacustica®'s Sound Stimulation Effects over Neurotransmitters, Cortisol, P-Amyloid (1-42), Thromboxane B2 and Telomere, on Cerebral Pons Representative Area, on the back of the head, and other Abnormal Body Locations, Using Bi-Digital O-Ring Test.","authors":"L. H. Uno, Marcelo P. de Paula, S. Iwasa, W. Falzoni, M. H. Tanaka, L. Alves, F. Barros, T. Higashi, Lair Ribeiro","doi":"10.3727/036012919x15675460598319","DOIUrl":"https://doi.org/10.3727/036012919x15675460598319","url":null,"abstract":"Thirty patients with marked depletion of neurotransmitters concentrations were noninvasively evaluated by Bi-Digital O-Ring Test (an electro-magnetic field (EMF) resonance phenomenon between two identical substances and amount1 ,2,3). Reference Control Substances (RCS) of\u0000 Serotonin, Acetylcholine, Dopamine, Cortisol, ~-Amyloid, Thromboxane B2, and Telomere were measured over cerebral pons representative area and any other abnormal region presented, before and after submitted to Neuroacustica® (a 60 minutes sound treatment). The results are as follow. The\u0000 average Serotonin on cerebral pons was 1.25 before and 150.33 mcg after (p<O. OOl*), on abnormal area was 12.91 before and 142.73 mcg after (p=O.003*). The average Acetylcholine on cerebral pons was 8.07 before and 1421.17 mcg after (p<O. OOl*), on abnormal area was 46.46 before and\u0000 1181.82 mcg after (p=O.003*). The average Dopamine on cerebral pons was 2.23 before and 156.20 mcg after (p<O. OOl*), on abnormal area was 8.06 before and 158.09 mcg after (p=O.003*). The average Thromboxane on cerebral pons was 217.80 before and 12.04 ng after (p<O. OOl*), on abnormal\u0000 area was 390.00 before and 18.02 ng after (p=O.003*). The average ~-Amyloid on cerebral pons was 17.33 before and 4.30 ng after (p=O. OOl*), on abnormal area was 10.78 before and 4.86 ng after (p=0.128). The average Cortisol on cerebral pons was 1353.23 before and 59.74 ng after (p<O. OOl*),\u0000 on abnormal area was 1037.83 before and 23.82 ng after (p=0.033*). The average Telomere on cerebral pons was 46.08 before and 375.18 ng after (p<O. OOl*), on abnormal area was 56.50 before and 446.25 ng after (p=0.012*). The average Normal Cell Telomere was 197.49 before and 473.52 ng after\u0000 (p<O. OOl*). Extra five patients in the same conditions (low levels of cerebral neurotransmitters) were submitted to the same procedure, and this time for a 24 hours follow up. In conclusion, hearing Neuroacustica® - Part 1, once, had favorable physiological effects, increasing sufficiently\u0000 normal cell Telomere, Serotonin, Acetylcholine, Dopamine; as well as decreasing satisfactorily Thromboxan B2, Cortisol, ~-Amyloid and Cancer Cell Telomere both in cerebral pons and on abnormal area. The effects may last in about 24 hours. The exposition to EMF, some sort of food and alcohol\u0000 may cancel it's benefits.","PeriodicalId":50881,"journal":{"name":"Acupuncture & Electro-Therapeutics Research","volume":" ","pages":""},"PeriodicalIF":0.3,"publicationDate":"2019-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46213273","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of Electroacupuncture Stimulation at Different Frequencies On Brain Waves 不同频率电针刺激对脑电波的影响
IF 0.3 4区 医学 Q4 INTEGRATIVE & COMPLEMENTARY MEDICINE Pub Date : 2019-03-01 DOI: 10.3727/036012919x15549226100455
Ji-Su Lee, Yu-Jin Choi, Seung-Hun Cho
{"title":"Effect of Electroacupuncture Stimulation at Different Frequencies On Brain Waves","authors":"Ji-Su Lee, Yu-Jin Choi, Seung-Hun Cho","doi":"10.3727/036012919x15549226100455","DOIUrl":"https://doi.org/10.3727/036012919x15549226100455","url":null,"abstract":"","PeriodicalId":50881,"journal":{"name":"Acupuncture & Electro-Therapeutics Research","volume":" ","pages":""},"PeriodicalIF":0.3,"publicationDate":"2019-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45413852","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Electro-magnetic Field Radiation of Mobile Phones As A Cause of Increased Release of Mercury from Amalgam Fillings and Risk of Harmful Effects on Health 移动电话的电磁场辐射是汞合金填充物中汞释放增加和对健康有害影响的一个原因
IF 0.3 4区 医学 Q4 INTEGRATIVE & COMPLEMENTARY MEDICINE Pub Date : 2019-03-01 DOI: 10.3727/036012919X15549226100473
D. Krstić, Momir Dunjic, Darko Zigar, S. Stanisic, Bojan Rajevic, Miloš Mirković, Jovanovic Z. Ignjatic, M. Dunjic, B. Stefanović, Katarina Dunjić, Mina Krstić
{"title":"Electro-magnetic Field Radiation of Mobile Phones As A Cause of Increased Release of Mercury from Amalgam Fillings and Risk of Harmful Effects on Health","authors":"D. Krstić, Momir Dunjic, Darko Zigar, S. Stanisic, Bojan Rajevic, Miloš Mirković, Jovanovic Z. Ignjatic, M. Dunjic, B. Stefanović, Katarina Dunjić, Mina Krstić","doi":"10.3727/036012919X15549226100473","DOIUrl":"https://doi.org/10.3727/036012919X15549226100473","url":null,"abstract":"","PeriodicalId":50881,"journal":{"name":"Acupuncture & Electro-Therapeutics Research","volume":" ","pages":""},"PeriodicalIF":0.3,"publicationDate":"2019-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48094868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ovarian Carcinoma Occurring After Breast Carcinoma Detection of Risk Factors Using Bdort Test Bdort试验检测乳腺癌后发生卵巢癌的危险因素
IF 0.3 4区 医学 Q4 INTEGRATIVE & COMPLEMENTARY MEDICINE Pub Date : 2019-03-01 DOI: 10.3727/036012919X15549226100437
M. Duniic, D. Krstić, Slaviša Stanišić, Miloš Mirković, M. Dunjic, N. Milicevic, Katarina Dunjić, Luka Dodic
{"title":"Ovarian Carcinoma Occurring After Breast Carcinoma Detection of Risk Factors Using Bdort Test","authors":"M. Duniic, D. Krstić, Slaviša Stanišić, Miloš Mirković, M. Dunjic, N. Milicevic, Katarina Dunjić, Luka Dodic","doi":"10.3727/036012919X15549226100437","DOIUrl":"https://doi.org/10.3727/036012919X15549226100437","url":null,"abstract":"","PeriodicalId":50881,"journal":{"name":"Acupuncture & Electro-Therapeutics Research","volume":"1 1","pages":""},"PeriodicalIF":0.3,"publicationDate":"2019-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43217295","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Acupuncture for the Treatment of Fatigue After Total Thyroidectomy in Women with Papillary Thyroid Cancer: A Pilot Study 针刺治疗癌症乳头状甲状腺全切除术后疲劳的初步研究
IF 0.3 4区 医学 Q4 INTEGRATIVE & COMPLEMENTARY MEDICINE Pub Date : 2019-03-01 DOI: 10.3727/036012919x15549226100464
E. Jeon, Min-ah Kwak, I. Shin, Seok-Bong Kang, H. Shon, E. Jung
{"title":"Acupuncture for the Treatment of Fatigue After Total Thyroidectomy in Women with Papillary Thyroid Cancer: A Pilot Study","authors":"E. Jeon, Min-ah Kwak, I. Shin, Seok-Bong Kang, H. Shon, E. Jung","doi":"10.3727/036012919x15549226100464","DOIUrl":"https://doi.org/10.3727/036012919x15549226100464","url":null,"abstract":"","PeriodicalId":50881,"journal":{"name":"Acupuncture & Electro-Therapeutics Research","volume":" ","pages":""},"PeriodicalIF":0.3,"publicationDate":"2019-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49001605","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
期刊
Acupuncture & Electro-Therapeutics Research
全部 Acc. Chem. Res. ACS Applied Bio Materials ACS Appl. Electron. Mater. ACS Appl. Energy Mater. ACS Appl. Mater. Interfaces ACS Appl. Nano Mater. ACS Appl. Polym. Mater. ACS BIOMATER-SCI ENG ACS Catal. ACS Cent. Sci. ACS Chem. Biol. ACS Chemical Health & Safety ACS Chem. Neurosci. ACS Comb. Sci. ACS Earth Space Chem. ACS Energy Lett. ACS Infect. Dis. ACS Macro Lett. ACS Mater. Lett. ACS Med. Chem. Lett. ACS Nano ACS Omega ACS Photonics ACS Sens. ACS Sustainable Chem. Eng. ACS Synth. Biol. Anal. Chem. BIOCHEMISTRY-US Bioconjugate Chem. BIOMACROMOLECULES Chem. Res. Toxicol. Chem. Rev. Chem. Mater. CRYST GROWTH DES ENERG FUEL Environ. Sci. Technol. Environ. Sci. Technol. Lett. Eur. J. Inorg. Chem. IND ENG CHEM RES Inorg. Chem. J. Agric. Food. Chem. J. Chem. Eng. Data J. Chem. Educ. J. Chem. Inf. Model. J. Chem. Theory Comput. J. Med. Chem. J. Nat. Prod. J PROTEOME RES J. Am. Chem. Soc. LANGMUIR MACROMOLECULES Mol. Pharmaceutics Nano Lett. Org. Lett. ORG PROCESS RES DEV ORGANOMETALLICS J. Org. Chem. J. Phys. Chem. J. Phys. Chem. A J. Phys. Chem. B J. Phys. Chem. C J. Phys. Chem. Lett. Analyst Anal. Methods Biomater. Sci. Catal. Sci. Technol. Chem. Commun. Chem. Soc. Rev. CHEM EDUC RES PRACT CRYSTENGCOMM Dalton Trans. Energy Environ. Sci. ENVIRON SCI-NANO ENVIRON SCI-PROC IMP ENVIRON SCI-WAT RES Faraday Discuss. Food Funct. Green Chem. Inorg. Chem. Front. Integr. Biol. J. Anal. At. Spectrom. J. Mater. Chem. A J. Mater. Chem. B J. Mater. Chem. C Lab Chip Mater. Chem. Front. Mater. Horiz. MEDCHEMCOMM Metallomics Mol. Biosyst. Mol. Syst. Des. Eng. Nanoscale Nanoscale Horiz. Nat. Prod. Rep. New J. Chem. Org. Biomol. Chem. Org. Chem. Front. PHOTOCH PHOTOBIO SCI PCCP Polym. Chem.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1