Pub Date : 2022-03-17DOI: 10.32552/2022.actamedica.655
Deniz Ateş Özdemir, K. Susesi
Autofluorescence (AF) or naïve-florescence is the natural emission of light by biomolecules. During florescence microscope examination, we realized that elastic tissue is brighter or more autoflourescent than collagen and other biomolecules/cells in the skin. Consequently, we decided to review elastic tissue-related pathologies under a florescence microscope and to report the possible benefits of this technique from selected cases from the paraffin-block archive, by using the protease digestion immunofluorescence method. Selected and clinic-pathologically confirmed 3 elastofibroma dorsi, 3 pseudoxanthoma elasticum, 3 anetoderma, 3 arteriovenous malformations, 3 temporal arteritis, 3 scar tissue and 3 highly solar-damaged samples of skin from 2014-2019 were retrieved. Under the fluorescent microscope, coarse, thick and globularly-fragmented elastic fibers of elastofibroma dorsi, shortened, irregular and convoluted elastic fibers of pseudoxanthoma elasticum, internal elastic membranes of arteries and their integrity was visualized. None of the anetoderma cases had any signal representing elastic tissue. It was shown that elastic tissue can be observed easily under fluorescence microscope in the case of FFPE tissues. The resulting autofluorescence can be useful in recognizing elastic tissue-related pathologies, and it may be used as an ancillary or an alternative method to routine histochemical techniques.
{"title":"The Potential Use of Elastic Tissue Autofluorescence in Formalin-fixed Paraffin-embedded Skin Biopsies","authors":"Deniz Ateş Özdemir, K. Susesi","doi":"10.32552/2022.actamedica.655","DOIUrl":"https://doi.org/10.32552/2022.actamedica.655","url":null,"abstract":"Autofluorescence (AF) or naïve-florescence is the natural emission of light by biomolecules. During florescence microscope examination, we realized that elastic tissue is brighter or more autoflourescent than collagen and other biomolecules/cells in the skin. Consequently, we decided to review elastic tissue-related pathologies under a florescence microscope and to report the possible benefits of this technique from selected cases from the paraffin-block archive, by using the protease digestion immunofluorescence method. Selected and clinic-pathologically confirmed 3 elastofibroma dorsi, 3 pseudoxanthoma elasticum, 3 anetoderma, 3 arteriovenous malformations, 3 temporal arteritis, 3 scar tissue and 3 highly solar-damaged samples of skin from 2014-2019 were retrieved. Under the fluorescent microscope, coarse, thick and globularly-fragmented elastic fibers of elastofibroma dorsi, shortened, irregular and convoluted elastic fibers of pseudoxanthoma elasticum, internal elastic membranes of arteries and their integrity was visualized. None of the anetoderma cases had any signal representing elastic tissue. It was shown that elastic tissue can be observed easily under fluorescence microscope in the case of FFPE tissues. The resulting autofluorescence can be useful in recognizing elastic tissue-related pathologies, and it may be used as an ancillary or an alternative method to routine histochemical techniques.","PeriodicalId":50891,"journal":{"name":"Acta Medica Mediterranea","volume":"7 1","pages":""},"PeriodicalIF":0.3,"publicationDate":"2022-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73202463","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-03-17DOI: 10.32552/2022.actamedica.592
Ş. Uzun, Murat Izgi, Turana Rasulova
Objective: Awake craniotomy is a procedure of choice when the area to be resected is close to the eloquent regions of the cerebral cortex. In this case report, the anesthetic technique in the awake craniotomy case presented. Case Presentation: A 62 years old female was scheduled for awake craniotomy procedure. Anatomically, the tumor involved the motor tracts of the right hand. Following the intravenous access and monitorization of the patient, 4.5 mg midazolam and 50 mcg of fentanyl used for sedation of the patient and dexmedetomidine was used for maintenance. We used Bispectral Electroencephalogram Index in order to measure the deepness of sedation during the surgery. Desaturation and hypercapnia on the arterial blood gas analysis seen following the addition of 3 mg of midazolam to deeper the sedation after hemostasis. The dose of dexmedetomidine increased and flumazenil administered to reverse the midazolam. Discussion: Dexmedetomidine belongs to alpha-2 adrenergic agonist group, which acts through its sedative effects at the locus coeruleus. Different from GABA, alpha-2 adrenoreceptors produce sedation without the entire spectrum of stupor letting patients stay somnolent and easily awakened with verbal stimuli becoming compatible to be tested. In conclusion, dexmedetomidine is one of the possible choices of medication for awake craniotomy as it maintains the patient’s convenience, reduces analgesic needs, and level of deliberateness without any confusion and agitation.
{"title":"Anesthetic Management with Dexmedetomidine During the Awake Craniotomy Surgery: A Case Report","authors":"Ş. Uzun, Murat Izgi, Turana Rasulova","doi":"10.32552/2022.actamedica.592","DOIUrl":"https://doi.org/10.32552/2022.actamedica.592","url":null,"abstract":"Objective: Awake craniotomy is a procedure of choice when the area to be resected is close to the eloquent regions of the cerebral cortex. In this case report, the anesthetic technique in the awake craniotomy case presented. \u0000Case Presentation: A 62 years old female was scheduled for awake craniotomy procedure. Anatomically, the tumor involved the motor tracts of the right hand. Following the intravenous access and monitorization of the patient, 4.5 mg midazolam and 50 mcg of fentanyl used for sedation of the patient and dexmedetomidine was used for maintenance. We used Bispectral Electroencephalogram Index in order to measure the deepness of sedation during the surgery. Desaturation and hypercapnia on the arterial blood gas analysis seen following the addition of 3 mg of midazolam to deeper the sedation after hemostasis. The dose of dexmedetomidine increased and flumazenil administered to reverse the midazolam. \u0000Discussion: Dexmedetomidine belongs to alpha-2 adrenergic agonist group, which acts through its sedative effects at the locus coeruleus. Different from GABA, alpha-2 adrenoreceptors produce sedation without the entire spectrum of stupor letting patients stay somnolent and easily awakened with verbal stimuli becoming compatible to be tested. In conclusion, dexmedetomidine is one of the possible choices of medication for awake craniotomy as it maintains the patient’s convenience, reduces analgesic needs, and level of deliberateness without any confusion and agitation.","PeriodicalId":50891,"journal":{"name":"Acta Medica Mediterranea","volume":"34 1","pages":""},"PeriodicalIF":0.3,"publicationDate":"2022-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73982661","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-03-16DOI: 10.32552/2022.actamedica.626
İhsan Alp Uzay, P. Dincer
Severe acute respiratory syndrome coronavirus -2 (SARS-CoV-2), is a novel Betacoronavirus variant that emerged in December 2019 causing the coronavirus disease 19 (COVID19) pandemic. It is reported that asymptomatic and presymptomatic individuals can transmit the virus and this silent transmission has been a major obstacle for the control of the pandemic. To overcome this obstacle, widespread testing with a rapid turnaround time is required. Reverse transcription-quantitative polymerase chain reaction (RT-qPCR) is currently the golden standard for the diagnosis of COVID19 worldwide. Even though RT-qPCR is an efficient method in terms of sensitivity and specificity, the need for elaborate instrumentation and skilled personnel restricts its widespread use. Restriction of RT-qPCR to a limited number of laboratories makes it further time-consuming. Many approaches are present to address the requirement for a rapid and accurate COVID19 diagnosis. In this review, different CRISPR-based approaches for the point-of-care diagnosis of COVID19 are compared. Among these approaches, CRISPR-FDS on-chip assay is found to be the best option as it is reported to be highly sensitive and specific, has a short turnaround time (15 min), does not need RNA isolation or special tools, and simple to perform. In terms of clinical validation, SHERLOCK, STOPCovid, and DETECTR were the most extensively studied ones and they are also reported to be highly sensitive and specific compared to RT-qPCR.
{"title":"CRISPR-based Approaches for the Point-of-Care Diagnosis of COVID19","authors":"İhsan Alp Uzay, P. Dincer","doi":"10.32552/2022.actamedica.626","DOIUrl":"https://doi.org/10.32552/2022.actamedica.626","url":null,"abstract":"Severe acute respiratory syndrome coronavirus -2 (SARS-CoV-2), is a novel Betacoronavirus variant that emerged in December 2019 causing the coronavirus disease 19 (COVID19) pandemic. It is reported that asymptomatic and presymptomatic individuals can transmit the virus and this silent transmission has been a major obstacle for the control of the pandemic. To overcome this obstacle, widespread testing with a rapid turnaround time is required. Reverse transcription-quantitative polymerase chain reaction (RT-qPCR) is currently the golden standard for the diagnosis of COVID19 worldwide. Even though RT-qPCR is an efficient method in terms of sensitivity and specificity, the need for elaborate instrumentation and skilled personnel restricts its widespread use. Restriction of RT-qPCR to a limited number of laboratories makes it further time-consuming. Many approaches are present to address the requirement for a rapid and accurate COVID19 diagnosis. In this review, different CRISPR-based approaches for the point-of-care diagnosis of COVID19 are compared. Among these approaches, CRISPR-FDS on-chip assay is found to be the best option as it is reported to be highly sensitive and specific, has a short turnaround time (15 min), does not need RNA isolation or special tools, and simple to perform. In terms of clinical validation, SHERLOCK, STOPCovid, and DETECTR were the most extensively studied ones and they are also reported to be highly sensitive and specific compared to RT-qPCR.","PeriodicalId":50891,"journal":{"name":"Acta Medica Mediterranea","volume":"48 1","pages":""},"PeriodicalIF":0.3,"publicationDate":"2022-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91036964","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-03-16DOI: 10.32552/2022.actamedica.640
Emrullah Söğütdelen, Mustafa Küçükyangöz
Objective: Production of a thesis during residency requires a great deal of dedication and effort. It is an honor to share the results of this effort with everyone when the thesis is published. In this study, we aimed to investigate the factors affecting the publication of a thesis in the field of urology. Methods: Theses completed between 2014 and 2018 were searched in the Institution of Higher Education Thesis Center. Keywords, title, and authors on the thesis were searched in the PubMed and Google Scholar databases. Journal tags were categorized according to whether they are indexed in Medline or not. Publication status was analyzed with the subject of the thesis, the year of thesis was completed, hospital where urology residents graduated, and the current workplace of the urologists. Results: Three hundred and fifty-three theses were analyzed in this study. The number of theses that were published in index journals and non-index journals was 65 (18.4) and 15 (4.2%), respectively. The median citation for published theses was 2 (0-21). The subject of the thesis, time passed after the thesis, and the current workplace of urologist was found to be statistically significant in the publication status of the theses (p<0.001, p= 0.02, p<0.001, respectively). Conclusion: Most of the theses produced by urologists were not published. Published theses received few citations. Theses produced from animal studies and a long period passed over the thesis increase the rate of publication. Urologists whose theses have been published mostly work in tertiary care hospitals.
{"title":"Publication Status of Urology Theses in Turkey","authors":"Emrullah Söğütdelen, Mustafa Küçükyangöz","doi":"10.32552/2022.actamedica.640","DOIUrl":"https://doi.org/10.32552/2022.actamedica.640","url":null,"abstract":"Objective: Production of a thesis during residency requires a great deal of dedication and effort. It is an honor to share the results of this effort with everyone when the thesis is published. In this study, we aimed to investigate the factors affecting the publication of a thesis in the field of urology. \u0000Methods: Theses completed between 2014 and 2018 were searched in the Institution of Higher Education Thesis Center. Keywords, title, and authors on the thesis were searched in the PubMed and Google Scholar databases. Journal tags were categorized according to whether they are indexed in Medline or not. Publication status was analyzed with the subject of the thesis, the year of thesis was completed, hospital where urology residents graduated, and the current workplace of the urologists. \u0000Results: Three hundred and fifty-three theses were analyzed in this study. The number of theses that were published in index journals and non-index journals was 65 (18.4) and 15 (4.2%), respectively. The median citation for published theses was 2 (0-21). The subject of the thesis, time passed after the thesis, and the current workplace of urologist was found to be statistically significant in the publication status of the theses (p<0.001, p= 0.02, p<0.001, respectively). \u0000Conclusion: Most of the theses produced by urologists were not published. Published theses received few citations. Theses produced from animal studies and a long period passed over the thesis increase the rate of publication. Urologists whose theses have been published mostly work in tertiary care hospitals.","PeriodicalId":50891,"journal":{"name":"Acta Medica Mediterranea","volume":"26 1","pages":""},"PeriodicalIF":0.3,"publicationDate":"2022-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78448415","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-12-07DOI: 10.32552/2021.actamedica.707
B. Armağan, B. Farisoğulları, H. Oral, L. Kılıç, Ş. Apraş Bilgen, S. Kiraz, U. Kalyoncu, I. Ertenli
Objective: Intravenous immunoglobulin is an alternative therapeutic agent that can be used off-label in many autoimmune rheumatological diseases. The aim of this study is to evaluate the autoimmune rheumatological diseases characteristics in which intravenous immunoglobulin therapy is used and the efficacy and safety of this therapy. Methods and Methods: We performed a retrospective review of 133 patients with autoimmune rheumatological disease who received at least 1 course of intravenous immunoglobulin treatment at Hacettepe University Rheumatology Outpatient Clinic between January 2013 and December 2020. The autoimmune rheumatological disease demographic and clinical features, organ involvements, treatment phases (primary-secondary or infection), treatment responses and adverse effects were evaluated. Results: A total of 79% (n=105) patients were female and the mean±SD age was 45.5±16.9 years. The most common underlying rheumatic diseases were systemic lupus erythematosus (35%, n=47) and dermatomyositis/polymyositis (35%, n=47). Intravenous immunoglobulin therapy was most commonly used for resistant/relapsed myositis and haematological involvement. The median (IQR) intravenous immunoglobulin treatment course was 6.5 (13) and the duration of intravenous immunoglobulin treatment was 10.8 (24) months. Although it is used as second-line therapy in 77% of patients, complete clinical response was observed in 32% and partial response in 47%. There was a significant reduction in the median (IQR) steroid doses (methylprednisolone or equivalent dose) patients received from baseline after intravenous immunoglobulin treatment [30 (33) vs 8 (12), p<0.0001]. It was observed that the use of conventional disease-modifying antirheumatic drugs decreased after intravenous immunoglobulin treatment and the use of rituximab increased. Adverse effects associated with intravenous immunoglobulin treatment (10%) and discontinuation (4%) were found to be very low. Conclusion: Intravenous immunoglobulin treatment was commonly given in systemic lupus erythematosus and dermatomyositis/polymyositis patients because of hematological involvement and resistant/relapsed myositis in our study, respectively. Although it is mainly the second-line treatment, two-thirds of the patients achieved a complete/partial response. Side effects and related discontinuation due to intravenous immunoglobulin treatment are very few.
{"title":"Evaluation of Intravenous Immunoglobulin G treatment in Outpatients Rheumatology Practice","authors":"B. Armağan, B. Farisoğulları, H. Oral, L. Kılıç, Ş. Apraş Bilgen, S. Kiraz, U. Kalyoncu, I. Ertenli","doi":"10.32552/2021.actamedica.707","DOIUrl":"https://doi.org/10.32552/2021.actamedica.707","url":null,"abstract":"Objective: Intravenous immunoglobulin is an alternative therapeutic agent that can be used off-label in many autoimmune rheumatological diseases. The aim of this study is to evaluate the autoimmune rheumatological diseases characteristics in which intravenous immunoglobulin therapy is used and the efficacy and safety of this therapy. \u0000Methods and Methods: We performed a retrospective review of 133 patients with autoimmune rheumatological disease who received at least 1 course of intravenous immunoglobulin treatment at Hacettepe University Rheumatology Outpatient Clinic between January 2013 and December 2020. The autoimmune rheumatological disease demographic and clinical features, organ involvements, treatment phases (primary-secondary or infection), treatment responses and adverse effects were evaluated. \u0000Results: A total of 79% (n=105) patients were female and the mean±SD age was 45.5±16.9 years. The most common underlying rheumatic diseases were systemic lupus erythematosus (35%, n=47) and dermatomyositis/polymyositis (35%, n=47). Intravenous immunoglobulin therapy was most commonly used for resistant/relapsed myositis and haematological involvement. The median (IQR) intravenous immunoglobulin treatment course was 6.5 (13) and the duration of intravenous immunoglobulin treatment was 10.8 (24) months. Although it is used as second-line therapy in 77% of patients, complete clinical response was observed in 32% and partial response in 47%. There was a significant reduction in the median (IQR) steroid doses (methylprednisolone or equivalent dose) patients received from baseline after intravenous immunoglobulin treatment [30 (33) vs 8 (12), p<0.0001]. It was observed that the use of conventional disease-modifying antirheumatic drugs decreased after intravenous immunoglobulin treatment and the use of rituximab increased. Adverse effects associated with intravenous immunoglobulin treatment (10%) and discontinuation (4%) were found to be very low. \u0000Conclusion: Intravenous immunoglobulin treatment was commonly given in systemic lupus erythematosus and dermatomyositis/polymyositis patients because of hematological involvement and resistant/relapsed myositis in our study, respectively. Although it is mainly the second-line treatment, two-thirds of the patients achieved a complete/partial response. Side effects and related discontinuation due to intravenous immunoglobulin treatment are very few.","PeriodicalId":50891,"journal":{"name":"Acta Medica Mediterranea","volume":"69 1","pages":""},"PeriodicalIF":0.3,"publicationDate":"2021-12-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76119824","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-11-29DOI: 10.32552/2021.actamedica.700
Aslıhan Uzun, Asena Keles Sahin
Objective: To identify the factors affecting surgical success in patients who underwent horizontal concomitant strabismus surgery. Materials and Methods: Medical records of 143 patients who underwent concomitant horizontal strabismus surgery and who were followed up at least 6 months at Ordu University, Faculty of Medicine, Department of Ophthalmology between January 2015 and December 2020 were reviewed retrospectively. Surgical success was defined as postoperative orthophoria or deviation angle of 10 prism diopters (PD) or less at 6 months after surgery. Results: 101 (70.63%) patients with esotropia and 42 (29.37%) patients with exotropia were operated. The mean follow-up period was 18.54 ± 17.51 months, the mean distance and near preoperative deviation were 46.94 ± 11.62 PD and 47.29 ± 11.81 PD, respectively. The surgical success was 83.92% in all patients, 87.13% in esotropic patients, and 76.19% in exotropic patients. Additional surgery was performed in 8 (5.59%) patients with >20 PD residual strabismus in the following year. Preoperative distance and near deviations were found to be significantly related with surgical success (p=0.020 and p=0.026). As the preoperative deviation decreases, the surgical success increases significantly. The deviation type, age at onset, age at the time of surgery, the interval between diagnosis and surgery, gender, or preoperative amblyopia were not significantly related to surgical success (p>0.05). Conclusion: The surgical success was found to be high following concomitant horizontal strabismus surgery. Since the preoperative deviation angle is the significant factor determining surgical success, preoperative evaluations should be done carefully. Patients and their parents should also be warned about the probability of additional surgery.
{"title":"Factors influencing surgical success in concomitant horizontal strabismus","authors":"Aslıhan Uzun, Asena Keles Sahin","doi":"10.32552/2021.actamedica.700","DOIUrl":"https://doi.org/10.32552/2021.actamedica.700","url":null,"abstract":"Objective: To identify the factors affecting surgical success in patients who underwent horizontal concomitant strabismus surgery. \u0000Materials and Methods: Medical records of 143 patients who underwent concomitant horizontal strabismus surgery and who were followed up at least 6 months at Ordu University, Faculty of Medicine, Department of Ophthalmology between January 2015 and December 2020 were reviewed retrospectively. Surgical success was defined as postoperative orthophoria or deviation angle of 10 prism diopters (PD) or less at 6 months after surgery. \u0000Results: 101 (70.63%) patients with esotropia and 42 (29.37%) patients with exotropia were operated. The mean follow-up period was 18.54 ± 17.51 months, the mean distance and near preoperative deviation were 46.94 ± 11.62 PD and 47.29 ± 11.81 PD, respectively. The surgical success was 83.92% in all patients, 87.13% in esotropic patients, and 76.19% in exotropic patients. Additional surgery was performed in 8 (5.59%) patients with >20 PD residual strabismus in the following year. Preoperative distance and near deviations were found to be significantly related with surgical success (p=0.020 and p=0.026). As the preoperative deviation decreases, the surgical success increases significantly. The deviation type, age at onset, age at the time of surgery, the interval between diagnosis and surgery, gender, or preoperative amblyopia were not significantly related to surgical success (p>0.05). \u0000Conclusion: The surgical success was found to be high following concomitant horizontal strabismus surgery. Since the preoperative deviation angle is the significant factor determining surgical success, preoperative evaluations should be done carefully. Patients and their parents should also be warned about the probability of additional surgery.","PeriodicalId":50891,"journal":{"name":"Acta Medica Mediterranea","volume":"13 1","pages":""},"PeriodicalIF":0.3,"publicationDate":"2021-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86859585","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-11-26DOI: 10.32552/2021.actamedica.526
Ekin Koç, A. Yıldız, M. E. Alagüney
Objectives: In this study, we gave information about appropriate working position to the office workers who have low back pain for last 3 months and we aimed to determine the effect of this intervention on frequency and level of low back pain and functionality of the workers. Materials and Methods: This study was an interventional study. Data were collected in September 2017 and December 2017 using face to face interview method. Information was given by a one-hour conference and distributing 4 informative brochures between October 2017 and November 2017. Results: 409 persons participated in the study and 141 of them who had low back pain for last 3 months formed the intervention group. 59.7% of the participants noted that they usually perform desk work. Logistic regression analysis showed that low back pain was 3,25 times more frequent among women than men, and 2,41 times more frequent among workers who had non-communicable disease. Among workers who had low back pain and attended the conference and read at least one brochure, mean Visual Analog Scale score was 5,97±1,2 before intervention and 5,03±1,1 after intervention (p<0,001) and mean Roland Morris Low Back Pain and Disability Questionnaire score were and 9,98±1,7 before intervention, and 8,91±1,3 after intervention, respectively (p<0,001). No difference was determined among workers who didn’t attend any of these two interventions (p>0,05). Conclusions: Considering the effect of intervention, this result shows that implementation of intervention with health promotion approach at workplace is an appropriate method for reducing severity of low back pain and increasing functionality.
{"title":"Is There an Effect of an Hour Education for Decreasing the Severity of Low Back Pain and Increasing Functionality in Office Workers?","authors":"Ekin Koç, A. Yıldız, M. E. Alagüney","doi":"10.32552/2021.actamedica.526","DOIUrl":"https://doi.org/10.32552/2021.actamedica.526","url":null,"abstract":"Objectives: In this study, we gave information about appropriate working position to the office workers who have low back pain for last 3 months and we aimed to determine the effect of this intervention on frequency and level of low back pain and functionality of the workers. \u0000Materials and Methods: This study was an interventional study. Data were collected in September 2017 and December 2017 using face to face interview method. Information was given by a one-hour conference and distributing 4 informative brochures between October 2017 and November 2017. \u0000Results: 409 persons participated in the study and 141 of them who had low back pain for last 3 months formed the intervention group. 59.7% of the participants noted that they usually perform desk work. Logistic regression analysis showed that low back pain was 3,25 times more frequent among women than men, and 2,41 times more frequent among workers who had non-communicable disease. Among workers who had low back pain and attended the conference and read at least one brochure, mean Visual Analog Scale score was 5,97±1,2 before intervention and 5,03±1,1 after intervention (p<0,001) and mean Roland Morris Low Back Pain and Disability Questionnaire score were and 9,98±1,7 before intervention, and 8,91±1,3 after intervention, respectively (p<0,001). No difference was determined among workers who didn’t attend any of these two interventions (p>0,05). \u0000Conclusions: Considering the effect of intervention, this result shows that implementation of intervention with health promotion approach at workplace is an appropriate method for reducing severity of low back pain and increasing functionality.","PeriodicalId":50891,"journal":{"name":"Acta Medica Mediterranea","volume":"7 1","pages":""},"PeriodicalIF":0.3,"publicationDate":"2021-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83916250","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-11-22DOI: 10.32552/2021.actamedica.551
Merve İnanç Tekin, Müge Pınar Çakar Özdal
Ocular manifestations in antineutrophil cytoplasmic antibody-associated vasculitis can be associated with the general or limited form of disease and can even occur in the absence of systemic disease. Ocular manifestations of associated vasculitis can be the first symptom of previously not manifested or undiagnosed systemic disease, allowing ophthalmologists to contribute to the diagnosis. Although its ocular findings are variable and nonspecific, the presence of necrotizing changes and peripheral corneal involvement accompanying scleral inflammation are important clues suggesting systemic vasculitis, especially associated vasculitis. The disease may affect all layers of the eye; scleritis and orbital involvement being the most common. Conjunctivitis, episcleritis, peripheral ulcerative keratitis, uveitis and retinal vasculitis are other ocular findings that may be observed during the disease course. Ocular involvement is most commonly seen in granulomatosis with polyangiitis followed by eosinophilic granulomatosis with polyangiitis and microscopic polyangiitis. Due to the high morbidity and mortality of associated vasculitis, it is very important to recognize the ocular manifestations of vasculitis as a sign of the underlying systemic disease and an indicator for the disease activity. Treatment varies depending on the location and severity of the ocular involvement. Although localized medical and surgical treatments can help to manage associated ocular disease, systemic immunosuppressive medications are often required to control the underlying disease. With the increasing availability and use of biological agents, prognosis has improved in patients with severe ocular complications. Rituximab appears to be useful in inducing remission and controlling relapses in patients with ocular involvement of associated vasculitis, particularly in cyclophosphamide resistant cases. A multidisciplinary approach in the diagnosis, treatment and follow-up of patients with associated vasculitis is required in order to achieve successful results.
{"title":"Ophthalmic Manifestations of ANCA-Associated Vasculitis","authors":"Merve İnanç Tekin, Müge Pınar Çakar Özdal","doi":"10.32552/2021.actamedica.551","DOIUrl":"https://doi.org/10.32552/2021.actamedica.551","url":null,"abstract":"Ocular manifestations in antineutrophil cytoplasmic antibody-associated vasculitis can be associated with the general or limited form of disease and can even occur in the absence of systemic disease. Ocular manifestations of associated vasculitis can be the first symptom of previously not manifested or undiagnosed systemic disease, allowing ophthalmologists to contribute to the diagnosis. Although its ocular findings are variable and nonspecific, the presence of necrotizing changes and peripheral corneal involvement accompanying scleral inflammation are important clues suggesting systemic vasculitis, especially associated vasculitis. The disease may affect all layers of the eye; scleritis and orbital involvement being the most common. Conjunctivitis, episcleritis, peripheral ulcerative keratitis, uveitis and retinal vasculitis are other ocular findings that may be observed during the disease course. \u0000Ocular involvement is most commonly seen in granulomatosis with polyangiitis followed by eosinophilic granulomatosis with polyangiitis and microscopic polyangiitis. Due to the high morbidity and mortality of associated vasculitis, it is very important to recognize the ocular manifestations of vasculitis as a sign of the underlying systemic disease and an indicator for the disease activity. Treatment varies depending on the location and severity of the ocular involvement. Although localized medical and surgical treatments can help to manage associated ocular disease, systemic immunosuppressive medications are often required to control the underlying disease. With the increasing availability and use of biological agents, prognosis has improved in patients with severe ocular complications. Rituximab appears to be useful in inducing remission and controlling relapses in patients with ocular involvement of associated vasculitis, particularly in cyclophosphamide resistant cases. A multidisciplinary approach in the diagnosis, treatment and follow-up of patients with associated vasculitis is required in order to achieve successful results.","PeriodicalId":50891,"journal":{"name":"Acta Medica Mediterranea","volume":"20 1","pages":""},"PeriodicalIF":0.3,"publicationDate":"2021-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83719794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-11-19DOI: 10.32552/2021.actamedica.683
Şafak Parlak, Ayca Akgoz Karaosmanoglu, Sevtap Arslan, L. Sennaroğlu
Objective: Incomplete partition type I is an uncommon congenital anomaly of the inner ear, characterized by typical cystic cochleovestibular appearance. Incomplete partition type I was firstly defined as cystic cochlea and vestibule without large vestibular aqueduct; however, large vestibular aqueduct and/or enlarged endolymphatic duct could rarely be seen in incomplete partition type I anomaly. Correct diagnosis of the type of cochlear malformation and differentiation of incomplete partition type I is necessary for patient management and surgical approach. Our aim was to document the temporal bone imaging findings in a series of patients with incomplete partition type I. Materials and Methods: CT (n=85) and/or MRI (n=80) examinations of 99 ears in 59 incomplete partition type I patients were retrospectively evaluated. All structures of the otic capsule were retrospectively assessed. The appearances of cochlea and vestibule, vestibular aqueduct/endolymphatic duct, semicircular canals were qualitatively evaluated by an experienced neuroradiologist. The vertical dimension of vestibular aqueduct and/or endolymphatic duct (from the point where the duct arises from the vestibule) was measured on CT/MRI. Anterior-posterior diameter of the internal acoustic canal and the diameter of cochlear aperture were measured on CT. The cochleovestibular nerves were evaluated on sagittal-oblique high T2-weighted imaging. Results: All 99 ears had defective partition with unpartitioned cochlear basal turn and absent interscalar septae, separated but cystic cochlea. The vestibule was enlarged in all ears except one. Semicircular canals were usually dysplastic (92.9%). A total of 35 incomplete partition type I ears (35.3%) had large vestibular aqueduct and/or enlarged endolymphatic duct. Internal acoustic canal was wide in 21% of ears. Cochlear aperture was wide in 5.9% of ears. Cochlear nerve was either hypoplastic or aplastic in about a quarter of incomplete partition type I ears. Conclusion: In up to one-third of incomplete partition type I patients, an associated large vestibular aqueduct /endolymphatic duct could be seen accompanying typical inner ear findings. Although the cochlear nerves are normal in the majority of cases, auditory brainstem implantation may be necessary in certain cases of incomplete partition type I anomaly.
{"title":"Incomplete Partition type I: Radiological Evaluation of the Temporal Bone","authors":"Şafak Parlak, Ayca Akgoz Karaosmanoglu, Sevtap Arslan, L. Sennaroğlu","doi":"10.32552/2021.actamedica.683","DOIUrl":"https://doi.org/10.32552/2021.actamedica.683","url":null,"abstract":"Objective: Incomplete partition type I is an uncommon congenital anomaly of the inner ear, characterized by typical cystic cochleovestibular appearance. Incomplete partition type I was firstly defined as cystic cochlea and vestibule without large vestibular aqueduct; however, large vestibular aqueduct and/or enlarged endolymphatic duct could rarely be seen in incomplete partition type I anomaly. Correct diagnosis of the type of cochlear malformation and differentiation of incomplete partition type I is necessary for patient management and surgical approach. Our aim was to document the temporal bone imaging findings in a series of patients with incomplete partition type I. \u0000Materials and Methods: CT (n=85) and/or MRI (n=80) examinations of 99 ears in 59 incomplete partition type I patients were retrospectively evaluated. All structures of the otic capsule were retrospectively assessed. The appearances of cochlea and vestibule, vestibular aqueduct/endolymphatic duct, semicircular canals were qualitatively evaluated by an experienced neuroradiologist. The vertical dimension of vestibular aqueduct and/or endolymphatic duct (from the point where the duct arises from the vestibule) was measured on CT/MRI. Anterior-posterior diameter of the internal acoustic canal and the diameter of cochlear aperture were measured on CT. The cochleovestibular nerves were evaluated on sagittal-oblique high T2-weighted imaging. \u0000Results: All 99 ears had defective partition with unpartitioned cochlear basal turn and absent interscalar septae, separated but cystic cochlea. The vestibule was enlarged in all ears except one. Semicircular canals were usually dysplastic (92.9%). A total of 35 incomplete partition type I ears (35.3%) had large vestibular aqueduct and/or enlarged endolymphatic duct. Internal acoustic canal was wide in 21% of ears. Cochlear aperture was wide in 5.9% of ears. Cochlear nerve was either hypoplastic or aplastic in about a quarter of incomplete partition type I ears. \u0000Conclusion: In up to one-third of incomplete partition type I patients, an associated large vestibular aqueduct /endolymphatic duct could be seen accompanying typical inner ear findings. Although the cochlear nerves are normal in the majority of cases, auditory brainstem implantation may be necessary in certain cases of incomplete partition type I anomaly.","PeriodicalId":50891,"journal":{"name":"Acta Medica Mediterranea","volume":"8 1","pages":""},"PeriodicalIF":0.3,"publicationDate":"2021-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88441809","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-11-19DOI: 10.32552/2021.actamedica.657
A. Şener, Gül Pamukçu Günaydın, F. Tanrıverdi
Objective: In cardiac arrest cases, high quality cardiopulmonary resuscitation and effective chest compression are vital issues in improving survival with good neurological outcomes. In this study, we investigated the effect of mechanical chest compression devices on 30- day survival in out-of-hospital cardiac arrest. Materials and Methods: This retrospective case-control study was performed on patients who were over 18 years of age and admitted to the emergency department for cardiac arrest between January 1, 2016 and January 15, 2018. Manual chest compression was performed to the patients before January 15, 2017, and mechanical chest compression was performed after this date. Return of spontaneous circulation, hospital discharge, and 30-day survival rates were compared between the groups of patients in terms of chest compression type. In this study, the LUCAS-2 model piston-based mechanical chest compression device was used for mechanical chest compressions. Results: The rate of return of spontaneous circulation was significantly lower in the mechanical chest compression group (11.1% vs 33.1%; p < 0.001). The 30-day survival rate was higher in the manual chest compression group (6.8% vs 3.7%); however, this difference was not statistically significant (p = 0.542). Furthermore, 30-day survival was 0% in the trauma group and 0.6% in the patient group who underwent cardiopulmonary resuscitation for over 20 minutes. Conclusion: It can be seen that the effect of mechanical chest compression on survival is controversial; studies on this issue should continue and, furthermore, studies on the contribution of mechanical chest compression on labor loss should be conducted.
目的:在心脏骤停病例中，高质量的心肺复苏和有效的胸部按压是提高生存率和良好神经预后的关键问题。在这项研究中，我们调查了机械胸外按压装置对院外心脏骤停患者30天生存率的影响。材料与方法:本回顾性病例对照研究纳入2016年1月1日至2018年1月15日因心脏骤停在急诊科就诊的18岁以上患者。患者于2017年1月15日前行手动胸外按压，1月15日后行机械胸外按压。比较两组患者胸压迫类型的自发循环恢复、出院率和30天生存率。本研究采用LUCAS-2型活塞式机械胸外按压装置进行机械胸外按压。结果:机械胸外按压组自发性循环恢复率明显低于机械胸外按压组(11.1% vs 33.1%;P < 0.001)。手动胸外按压组30天生存率较高(6.8% vs 3.7%);但差异无统计学意义(p = 0.542)。此外，心肺复苏超过20分钟的创伤组30天生存率为0%，患者组为0.6%。结论:可见机械胸外按压对生存率的影响存在争议;对这一问题的研究应继续进行，并进一步研究机械胸外按压对产程损失的影响。
{"title":"Mechanical Versus Manual Chest Compression: A Retrospective-Cohort in Out-of-Hospital Cardiac Arrest","authors":"A. Şener, Gül Pamukçu Günaydın, F. Tanrıverdi","doi":"10.32552/2021.actamedica.657","DOIUrl":"https://doi.org/10.32552/2021.actamedica.657","url":null,"abstract":"Objective: In cardiac arrest cases, high quality cardiopulmonary resuscitation and effective chest compression are vital issues in improving survival with good neurological outcomes. In this study, we investigated the effect of mechanical chest compression devices on 30- day survival in out-of-hospital cardiac arrest. \u0000Materials and Methods: This retrospective case-control study was performed on patients who were over 18 years of age and admitted to the emergency department for cardiac arrest between January 1, 2016 and January 15, 2018. Manual chest compression was performed to the patients before January 15, 2017, and mechanical chest compression was performed after this date. Return of spontaneous circulation, hospital discharge, and 30-day survival rates were compared between the groups of patients in terms of chest compression type. In this study, the LUCAS-2 model piston-based mechanical chest compression device was used for mechanical chest compressions. \u0000Results: The rate of return of spontaneous circulation was significantly lower in the mechanical chest compression group (11.1% vs 33.1%; p < 0.001). The 30-day survival rate was higher in the manual chest compression group (6.8% vs 3.7%); however, this difference was not statistically significant (p = 0.542). Furthermore, 30-day survival was 0% in the trauma group and 0.6% in the patient group who underwent cardiopulmonary resuscitation for over 20 minutes. \u0000Conclusion: It can be seen that the effect of mechanical chest compression on survival is controversial; studies on this issue should continue and, furthermore, studies on the contribution of mechanical chest compression on labor loss should be conducted.","PeriodicalId":50891,"journal":{"name":"Acta Medica Mediterranea","volume":"30 1","pages":""},"PeriodicalIF":0.3,"publicationDate":"2021-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84572146","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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