Acta Medica Mediterranea最新文献

{"title":"Unusual Presentation of Follicular Lymphoma with the Involvement of Bilateral Ear Helices and Lobes","authors":"Ecem Bostan, A. Karaduman, Ece Özoğul, S. Akın","doi":"10.32552/2022.actamedica.736","DOIUrl":"https://doi.org/10.32552/2022.actamedica.736","url":null,"abstract":"Follicular lymphoma is a type of systemic lymphomas which constitutes approximately 30-35% of all Non-Hodgkin lymphomas. It typically presents itself in the form of generalized lymphadenopathy, hepatomegaly, splenomegaly and bone marrow involvement. Cutaneous involvement of follicular lymphoma generally appears as skin-coloured to red, violaceous papules or nodules most commonly involving the scalp, trunk and head&neck region. Herein, we would like to present an unusual case of follicular lymphoma which appears as skin-coloured papules prominent upon the both ears and trunk.","PeriodicalId":50891,"journal":{"name":"Acta Medica Mediterranea","volume":"33 1","pages":""},"PeriodicalIF":0.3,"publicationDate":"2022-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84280361","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigation of Mean Platelet Volume as a Prognostic Criterion in Non-Healing Wounds","authors":"F. Tutak, F. Doğan, Aşkı Vural","doi":"10.32552/2022.actamedica.673","DOIUrl":"https://doi.org/10.32552/2022.actamedica.673","url":null,"abstract":"Objective: We aimed to evaluate if the Mean Platelet Volume (MPV) is an acute phase reactant in non-healing wounds, by analyzing its correlation with Erythrocyte Sedimentation Rate (ESR). \u0000Method: Our study was carried out in a descriptive type with the participation of patients with non-healing wounds. The laboratory data and characteristics of the patients were accessed retrospectively, and the obtained data were recorded in the data recording form. \u0000Results: The sample group consisted of 92 patients with non-healing wounds. 26.9% of the patients with non-healing wounds had pressure sores, 37.6% of them had diabetic foot wounds, 18.3% had non-healing wounds developed after trauma, and 17.2% had necrotizing fasciitis. The average age of the patients was 53.22±19.13, and the average length of stay in the hospital was 108.98±18.78 (min 3 months, max 6 months) days. The MPV value, which was found to be high in the early stages of non-healing wounds, decreased after the wound was completely healed. When the MPV value was compared to ESR, an acute phase reactant, a positive and strong statistically significant correlation was found between MPV and ESR based on the result of this correlation analysis (r=0.256, p<0.01). \u0000Conclusion: MPV can be used as a marker, just like ESR, in the presence of non-healing wounds. MPV value can be measured with blood taken into the complete blood count. However, an extra blood sample and a different tube are required for ESR. Using MPV value instead of ESR will provide savings in terms of cost and labor.","PeriodicalId":50891,"journal":{"name":"Acta Medica Mediterranea","volume":"8 1","pages":""},"PeriodicalIF":0.3,"publicationDate":"2022-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72524002","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Relationship Between ST-Segment Depression in Lead aVR and Coronary Microvascular Function in Acute Inferior Myocardial Infarction","authors":"B. Aslan, M. Karahan","doi":"10.32552/2022.actamedica.681","DOIUrl":"https://doi.org/10.32552/2022.actamedica.681","url":null,"abstract":"Aim: The aim of this study was to investigate the relationship between ST-segment depression in the aVR lead and coronary microvascular function in acute inferior myocardial infarction undergoing primary percutaneous intervention. \u0000Methods:  287 patients with inferior myocardial infarction confirmed by coronary angiography were divided into two groups with and without ST-segment depression in lead aVR  ≥ 0.1 mV on the 12 lead ECG. Electrocardiographic recordings were made for the evaluation of ST-segment resolution before and after primary PCI. Angiographic assessment in the infarct-related artery was performed by using the myocardial blush grade and thrombolysis in myocardial infarction flow.   \u0000Results: Overall, 51 of 287 patients had ST-segment depression in lead aVR. The number of patients with RCA-induced infarction was higher in the group with ST-segment depression in lead aVR. RCA involvement was present in 44 patients. Peak troponin was higher in the group with ST-segment depression in lead aVR compare to the other group (P <0.001). The MBG was more impaired, and the STR was less regressed in patients with ST depression in lead aVR  (p<0,001). The ejection fraction of patients with ST-segment depression in lead aVR was lower. \u0000Conclusion: We found that ST-segment depression in lead aVR was associated with impaired myocardial perfusion in patients with inferior myocardial infarction.","PeriodicalId":50891,"journal":{"name":"Acta Medica Mediterranea","volume":"500 1","pages":""},"PeriodicalIF":0.3,"publicationDate":"2022-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90251672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of Clinical Profiles, Angiographic Features and Outcomes of Young and Elderly Patients with ST-Segment Elevation Myocardial Infarction","authors":"Bektaş Murat, S. Murat","doi":"10.32552/2022.actamedica.670","DOIUrl":"https://doi.org/10.32552/2022.actamedica.670","url":null,"abstract":"Objective: It is to reveal the differences between clinical, angiographic, in-hospital and one-year follow-up results between young and elderly patients with acute ST-segment elevation myocardial infarction. \u0000Material and Methods: This study was designed retrospectively in two centers. 2891 patients were screened; 260 of which were young. 260 elderly patients were randomly selected among the patients and the differences between both groups were evaluated. \u0000Results: The median age of the young patients was 37 (34-39) years and the median age of the elderly patients was 65 (56-73) years, and male gender was dominant in both groups. Young patients were more likely to be admitted with Killip class 1, while older patients were more likely to be admitted with Killip class 2 (P=0.002). Single-vessel disease was more common in young patients (81.0% vs. 46.3%; P<0.001), while multi-vessel disease was more common in the elderly patients (19.0% vs. 53.7%; P<0.001). In one-year follow-up, all-cause hospitalization was lower in younger patients, but there was no significant difference in mortality between elderly and young patients. \u0000Conclusion: Young patients presenting with ST-segment elevation myocardial infarction were more frequent smokers, obese and dyslipidemic and although in-hospital outcomes were better than the elderly, one-year mortality was similar to those of the elderly.","PeriodicalId":50891,"journal":{"name":"Acta Medica Mediterranea","volume":"4 1","pages":""},"PeriodicalIF":0.3,"publicationDate":"2022-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79062804","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of Sleep Quality with Use of Angiotensin Receptor Neprilysin Inhibitor in Patients with Reduced Ejection Fraction Heart Failure","authors":"F. Işık, M. Okşul, B. Aslan, E. Taştan","doi":"10.32552/2022.actamedica.645","DOIUrl":"https://doi.org/10.32552/2022.actamedica.645","url":null,"abstract":"Background and Aim: It is known that chronic heart failure reduces sleep quality by causing sleep problems. In recent years, it has been observed that sacubitril-valsartan, which is an angiotensin receptor neprilysin inhibitor, reduces mortality and hospitalization in patients with heart failure. The aim of our study is to examine whether sacubitril-valsartan affects sleep quality in patients with reduced ejection fraction heart failure apart from these benefits. \u0000Material and Method: In our study, 44 patients with a history of heart failure with reduced ejection fraction applied to our cardiology outpatient clinic of Gazi Yaşargil Training and Research Hospital were included. Demographic, clinical, laboratory, electrocardiographic, and echocardiographic parameters of these patients were examined. Sacubitril-valsartan treatment was initiated in all patients. Dose titration was performed in patients who could tolerate the treatment. Pittsburgh sleep quality index questionnaire was performed in all patients before treatment and at the end of the second month. \u0000Result: The median age of the study population was 61.5 (47.2 - 70.7, IQR) years and 30 (68.2 %) of them were male. There were 30 (72.7 %) ischemic heart failure patients and 14 (27.3 %) non-ischemic heart failure patients. There was a significant decrease in the number of patients with poor sleep quality after angiotensin receptor neprilysin inhibitor treatment compared to baseline [36 (81.8 %) vs 30 (68.2 %), p= 0.031]. In addition, there was a significant decrease in the total Pittsburgh sleep quality index score of patients compared to the baseline [9.0 (7.0 - 12.0) vs 7.0 (5.0 - 9.0), p < 0.001]. \u0000Conclusion: In our study, we observed that sacubitril-valsartan treatment improves sleep quality in patients with reduced ejection fraction heart failure.","PeriodicalId":50891,"journal":{"name":"Acta Medica Mediterranea","volume":"70 1","pages":""},"PeriodicalIF":0.3,"publicationDate":"2022-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89732489","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dyspnea and Dysphagia as First Sign of Hypopharyngoesophageal Lipoma","authors":"Monika Adásková, K. Obtulovičová, M. Sičák","doi":"10.32552/2022.actamedica.591","DOIUrl":"https://doi.org/10.32552/2022.actamedica.591","url":null,"abstract":"We present a rare case of a 72-years old male with a big lesion coming out from his mouth suddenly. Examination showed a mucosal lesion seen outside of the mouth, saliva running outside, he was not able to swallow, it was hard to speak and breathe for him. At the time of arrival the patient was stable, later developed a distress and dyspnoe because of the part of tumor inside of his mouth was moving in and out on breathing and was obstructing his airway. This situation required an urgent tracheostomy to secure the patient’s airway. After tracheostomy we continued with endaural approach technique to remove the tumor, the origin of lesion was identified within the postcricoid area. Lesion was removed safely, sent to histology with no complication after. Results came back as a lipoma pedunculated. Literature search did not reveal any cases of limb lipoma presenting with a sudden hanging tumor causing airway compromise and dysphagia, all cases were diagnosed during routine examination. Our case has proven that hypopharyngoesophageal lipoma can present as an acute condition and we have to be able to save and manage patients like this.","PeriodicalId":50891,"journal":{"name":"Acta Medica Mediterranea","volume":"59 1","pages":""},"PeriodicalIF":0.3,"publicationDate":"2022-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75765534","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Factors Related to the 6 Minute Walk Test: The Experience of a Referral Lung Transplantation Center","authors":"Pınar Atagün Güney","doi":"10.32552/2022.actamedica.692","DOIUrl":"https://doi.org/10.32552/2022.actamedica.692","url":null,"abstract":"Objectives: The 6-minute-walk test is a practical and widely used test, which indicates the exercise capacity in patients with a severe pulmonary disease. The study aims to investigate the related factors with the 6-minute-walk test in lung transplantation candidates. \u0000Materials and Method: The data were collected retrospectively from 349 patients, between January 2012 and September 2020. The patients were grouped according to their underlying lung disease as obstructive lung diseases, interstitial lung diseases, and infective lung diseases. The data collected included patient demographics, gender, body mass index, artery blood gas, the results of the respiratory function test, six-minute walk test, long-term oxygen therapy, and the need for non-invasive mechanical ventilation [such as group 1 (6MWD<200) and group 2(6MWD≥200)]. All of the collected data were analyzed and compared between the groups. \u0000Results: Overall, 349 patients were included in the study, and there were 123 females and 226 males (35.2% and 64.8% respectively) with a mean age of 46.92 ± 14.1 years. Their mean body mass index was 23.58 ± 12.52 kg/m2, the median FEV1(%) was 35.3 (33.4-37.2), the median six-minute walk distance was 222 m (125-335 m), and the mean PaO2/FiO2 (P/F) was 250.32% ± 74.81, the mean PCO2 was 45.71 mmHg ± 11.97. Furthermore, the patients using long-term oxygen therapy were (n=274, 78.5%) and non-invasive mechanical ventilation were (n=125, 35.8%). The mortality status, P/F, long-term oxygen therapy usage, and non-invasive mechanical ventilation usage were different between Group 1 and Group 2 (p=0.001, p=0.001, p<0.001, and p<0.001, respectively). There was no difference between the groups in patients with and without IPF between underlying diseases. The 6-minute walk test was found to have moderate correlation with FEV1 and P/F; and a negative correlation with age and PCO2 (p<0.01, r=0.33.8, p<0.001, r= 38.1 and p=0.17, r=12,7, p<0.001, r=-0.30.6, respectively). There was no correlation between P/F, FEV1, and body mass index; and also, between PCO2, age, and body mass index. Age had a weak correlation with FEV1(p<0.001, r=19.3). There was no correlation between the age and 6MWD, as well as P/F, PCO2, and the body mass index. The factors affecting survival in multivariate analysis were investigated by using the Cox regression model. It was observed that gender (OR, 0.001; 95% CI, 0.246-0.716; p=0.42), FEV1(OR, 1.02; 95% CI, 1.00-1.04; p<0.001), P/F (OR, 1.00; 95% CI, 1.00-1.01; p<0.001), and LTOT (OR, 9.83; 95% CI, 3.70-26.14; p<0.001) were independent factors associated with 6MWD<200 m. \u0000Conclusion: The 6-minute walk test is associated with mortality, gender, poor oxygenation, and with the utilization of domiciliary non-invasive mechanical ventilation or long-term oxygen therapy. Furthermore, it is an independent risk factor for mortality in lung transplant candidates and in providing a valuable method for the management of patients.","PeriodicalId":50891,"journal":{"name":"Acta Medica Mediterranea","volume":"43 1","pages":""},"PeriodicalIF":0.3,"publicationDate":"2022-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74469991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of Favipiravir to Hydroxychloroquine Plus Azithromycin in the Treatment of Patients with Non-critical COVID-19: A Single-center, Retrospective, Propensity Score-matched Study","authors":"O. A. Uyaroğlu, M. Ç. Sönmezer, G. Telli Dizman, Nursel Çalık Başaran, S. Karahan, Ö. Uzun","doi":"10.32552/2022.actamedica.719","DOIUrl":"https://doi.org/10.32552/2022.actamedica.719","url":null,"abstract":"Objectives: In this study, we compared the clinical outcomes and effects of the treatments on laboratory parameters between patients who were treated with favipiravir (FAV) or hydroxychloroquine plus azithromycin (HCQ/AZ) for COVID-19 pneumonia in non-Intensive Care Unit (non-ICU) patients. \u0000Methods: We collected data of 260 moderate or severe COVID-19 patients hospitalized in COVID-19 wards between March 20, 2020, and September 30, 2020 retrospectively. We used propensity score matching to evaluate treatment effect on laboratory parameters of COVID-19 infection. \u0000Results: We compared 42 patients using FAV and 42 HCQ/AZ after propensity score matching. While there were statistical differences between the therapy groups in terms of transfer to ICU and/or exitus before matching (p=0.031), this was not significant after propensity analysis (p=0.250). Patients treated with FAV stayed in the hospital nearly one more day than HCQ/AZ group but the difference was not statistically significant (9.02 days vs 8.14 days, p=0.903). The levels of AST,ALT, and LDH increased at discharge in both groups, especially in the FAV group. \u0000Conclusions: FAV is not superior to HCQ/AZ in the treatment of COVID-19 infection in hospitalized patients with pneumonia.","PeriodicalId":50891,"journal":{"name":"Acta Medica Mediterranea","volume":"23 1","pages":""},"PeriodicalIF":0.3,"publicationDate":"2022-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90085146","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effect of Different Therapeutic Modalities on Demodex Densities and Clinical Symptoms of Patients with Demodicosis","authors":"Başak Yalıcı Armağan, N. Atakan","doi":"10.32552/2022.actamedica.721","DOIUrl":"https://doi.org/10.32552/2022.actamedica.721","url":null,"abstract":"Background: Demodicosis represents cutaneous diseases caused by cutaneous overpopulation of Demodex mites. The aim of this study was to evaluate the effect of different treatment options on Demodex densities (Dds) and clinical symptoms of patients with demodicosis. \u0000Methods: Patients with high Dds in two consecutive standardized skin surface biopsies (SSSB1>5 D/cm2 or SSSB2>10 D/cm²) and concomitant clinical symptoms were evaluated retrospectively. Measurements of treatment effectiveness included clinical improvement and normalization or reducing of Dds. \u0000Results: A total of 21 patients included in the study. Five patients received topical permethrin and crotamiton whereas 16 patients received systemic metronidazole in combination with topical permethrin and/or crotamiton. The treatment was continued with topical ivermectin in 2 patients who had failure with other treatments. The median treatment duration was 3 months (IQR 1-4). Pre- and post-treatment median Dds decreased 30 to 14 D/cm2 on SSSB1 whereas 81 to 80 D/cm2 on SSSB2, respectively. There was no statistically significant decrease in Dds on SSSB1 and SSSB2 after the treatment (p=0.173 and p=0.134, respectively). Clinical improvement was recorded in a total of 14 patients (66.6%) of whom only 2 patients (9.5%) had normalization on Dds. Additionally, topical ivermectin provided a rapid clinical improvement and normalization on Dds in both 2 patients. \u0000Conclusion: Irrespective of the treatment, more than two-thirds of the patients improved clinically without a significant change in Dds. This finding may suggest that the treatment response has been mostly associated with the anti-inflammatory properties of the agents. Topical ivermectin seems to be a more suitable treatment option for demodicosis with positive effects on both clinical findings and Dds.","PeriodicalId":50891,"journal":{"name":"Acta Medica Mediterranea","volume":"2 1","pages":""},"PeriodicalIF":0.3,"publicationDate":"2022-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90446076","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Distribution of Intestinal Parasites Detected in Ankara Training and Research Hospital between 2017 and 2020","authors":"Filiz Kaya, M. Kocaağa","doi":"10.32552/2022.actamedica.715","DOIUrl":"https://doi.org/10.32552/2022.actamedica.715","url":null,"abstract":"Objective: The aim of this study was to evaluate the current prevalence of intestinal parasites in patients admitted to Ankara Training and Research Hospital during the period of 2017 to 2020. \u0000Materials and Methods: Intestinal parasitic examination results of patients between 2017 and 2020 were evaluated retrospectively. Data on demographic and clinical parameters were obtained from the laboratory information management system. \u0000Results: E. vermicularis eggs were found in 7.2% of 2348 samples examined by cellophane tape method. One or more intestinal parasites were detected in 18.2% of 4211 samples examined stool concentration method. Intestinal parasite positivity was the highest in children aged 6-18 years among age groups. The most frequently detected intestinal parasites were Blastocystis sp., E. vermicularis, Dientamoeba fragilis and Giardia intestinalis. \u0000Conclusion: Although our hospital is in the center of Ankara Training and Research Hospital, it mostly serves patients with low socioeconomic status and immigrant individuals; therefore total intestinal parasite detection rate was found relatively high. Intestinal parasitic infections are still an important public health issue in our country. It is important to determine the prevalence of parasitic infections to develop optimal prevention and treatment strategies.","PeriodicalId":50891,"journal":{"name":"Acta Medica Mediterranea","volume":"102 1","pages":""},"PeriodicalIF":0.3,"publicationDate":"2022-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73220903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}