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consequences of long-term therapy with proton pump inhibitors 质子泵抑制剂长期治疗的后果
Pub Date : 2024-01-16 DOI: 10.12775/jehs.2024.53.004
Zuzanna Drygała, Julia Wyrwał, Martyna Krasuska, Karolina Nowak, Zuzanna Olejarz, Zuzanna Zielińska, Magdalena Słowik, Karolina Nowak, Maria Nieć, Katarzyna Gierlach
Introduction and purpose: Proton pump inhibitors (PPIs) were first developed in the late 1970s and introduced to the market in 1989. They are one of the most commonly prescribed medications worldwide. PPIs reduce gastric acid secretion in the stomach by inhibiting the hydrogen-potassium ATPase enzyme. They have revolutionized the treatment of diseases related to excessive stomach acid secretion. Among the drugs belonging to this class, we should mention omeprazole, esomeprazole, pantoprazole, lansoprazole, dexlansoprasole and rabeprazole.  A brief description of the state of knowledge: Since the 1990s, the use of proton pump inhibitors has been consistently increasing. Doctors prescribe these drugs more frequently, in higher doses, and for longer durations, although such practices are only sometimes fully justified. Although using them for a short period (less than eight weeks) is relatively safe, there is growing evidence of possible risks linked to their extended use. Many studies highlight the impact of long-term therapy on the development of tumors, deficiencies in micronutrients, the functioning of the skeletal, urinary, nervous, and cardiovascular systems, and the development of infections and diabetes.  Summary (conclusions): Indeed, long-term therapy with proton pump inhibitors has an impact on the functioning of the body. Considering the increasing popularity of proton pump inhibitors and their expanding use, it is worth contemplating a more prudent prescription of these drugs by doctors. It should also be noted that the majority of studies are based on prescription PPIs. Future researchers must also take over-the-counter (OTC) medications into account.
简介和目的:质子泵抑制剂(PPIs)于 20 世纪 70 年代末首次开发,1989 年投放市场。它们是全球最常用的处方药之一。质子泵抑制剂通过抑制氢钾 ATP 酶来减少胃酸分泌。它们为治疗与胃酸分泌过多有关的疾病带来了革命性的变化。在这类药物中,我们应该提到奥美拉唑、埃索美拉唑、泮托拉唑、兰索拉唑、右兰索拉唑和雷贝拉唑。 知识现状简述:自 20 世纪 90 年代以来,质子泵抑制剂的使用一直在持续增加。医生更频繁、更大剂量、更长时间地使用这些药物,尽管这种做法有时并不完全合理。虽然短期使用(少于八周)质子泵抑制剂相对安全,但越来越多的证据表明,长期使用质子泵抑制剂可能存在风险。许多研究强调了长期治疗对肿瘤发展、微量元素缺乏、骨骼、泌尿、神经和心血管系统功能以及感染和糖尿病发展的影响。 总结(结论):事实上,长期服用质子泵抑制剂会对身体机能产生影响。考虑到质子泵抑制剂越来越受欢迎,其使用范围也在不断扩大,医生在开处方时应该更加谨慎。还应注意的是,大多数研究都是基于处方质子泵抑制剂。未来的研究人员还必须考虑到非处方药(OTC)。
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引用次数: 0
The vicious circle mechanism in atopic dermatitis: psychological distress as cause and effect of atopic dermatitis 特应性皮炎的恶性循环机制:心理困扰是特应性皮炎的因果关系
Pub Date : 2024-01-16 DOI: 10.12775/jehs.2024.53.005
Karolina Nowak, Zuzanna Olejarz, Zuzanna Drygała, Julia Wyrwał, Zuzanna Zielińska, Magdalena Słowik, Karolina Nowak, Maria Nieć, Katarzyna Gierlach, Martyna Krasuska
Introduction and purpose:  Atopic dermatitis (AD) is chronic inflammatory skin disorder. It typically begins in infancy or childhood and might persist into adulthood. AD is characterized by dry, itchy, eczematous skin. The lesions can vary in intensification from mild to severe according to patient age or body region. AD requires ongoing management to control the symptoms. Skin manifestations along with the demand of treatment and care regimens significantly impact quality of life (QOL) in patients with AD. Individuals suffering from this condition are more prone to developing mental health disorders, which are often linked to emotional stress they experience. Exposure to stress exacerbates AD and stimulates skin changes, which in turn leads to intensification of treatment regimens. This cause-and-effect chain can be considered as a vicious circle mechanism. The aim of the review is to highlight the phenomenon by examining current literature on this topic in order to raise the awareness of healthcare professionals regarding this subject as well as implement appropriate and complete support for patients struggling with AD.  A brief description of the state of knowledge:  The pathophysiology of AD is multifactorial. Numerous studies explore the impact of stress on the deterioration of AD symptoms and delve into its pathogenic concepts. Simultaneously, researchers highlight increased psychological distress in AD patients, which surpass that observed in many other chronic conditions. Summary:  Psychological factors play a significant role in AD. It demands considering mental health screening and support as a part of clinical practice, treating AD patients. Further research is necessary to provide efficient and comprehensive interventions. 
简介和目的:特应性皮炎(AD)是一种慢性炎症性皮肤病。它通常始于婴儿期或儿童期,可能会持续到成年。特应性皮炎的特点是皮肤干燥、瘙痒、湿疹。根据患者年龄或身体部位的不同,皮损程度也会从轻微到严重不等。AD 需要持续治疗以控制症状。皮肤表现以及对治疗和护理方案的需求极大地影响了 AD 患者的生活质量(QOL)。这种疾病的患者更容易患上精神疾病,而精神疾病往往与他们所经历的情绪压力有关。压力会加重注意力缺失症并刺激皮肤发生变化,进而导致治疗方案的强化。这一因果链可被视为一种恶性循环机制。本综述旨在通过研究当前有关这一主题的文献来强调这一现象,从而提高医护人员对这一主题的认识,并为与注意力缺失症斗争的患者提供适当而全面的支持。 知识现状简述: 注意力缺失症的病理生理学是多因素的。大量研究探讨了压力对注意力缺失症症状恶化的影响,并深入探讨了其致病概念。同时,研究人员还强调了注意力缺失症患者心理压力的增加,其程度超过了许多其他慢性疾病。总结:心理因素在注意力缺失症中扮演着重要角色。这就要求在治疗注意力缺失症患者时,将心理健康筛查和支持作为临床实践的一部分。有必要开展进一步研究,以提供高效、全面的干预措施。
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引用次数: 0
The impact of consumed coffee on the digestive system - review of the latest research 饮用咖啡对消化系统的影响--最新研究综述
Pub Date : 2024-01-14 DOI: 10.12775/jehs.2024.53.003
Nina Taborska, A. Martyka, Martyna Kubicka - Figiel, Przemysław Ujma
IntroductionCoffee stands as the second most widely consumed beverage globally, following water.[1] Recent research on the effects of coffee consumption underscores its positive outcomes when adhering to recommended doses—typically ranging from 2 to 5 cups a day, amounting to a maximum of 400 mg of caffeine daily. This newfound perspective highlights the potential benefits of moderate coffee intake on our overall health and well-being. Aim of the studyThe objective of this study was to comprehensively review the existing knowledge regarding the impact of coffee consumption on diverse aspects of the gastrointestinal tract.Materials and methodologyA literature review was conducted utilizing the PubMed, Google Scholar, and Google databases. Articles were systematically searched in both English and Polish, employing the keywords: coffee, caffeine, digestive system, digestion, and cancer.ResultsRecent research highlights coffee's diverse benefits, aiding digestion, hastening transit, and showing potential in cancer prevention. It stimulates gastric acid, enhances bile and pancreatic secretion, reduces gallstone risk, promotes large intestine movement, and modulates intestinal flora. Importantly, coffee isn't a primary factor in conditions like reflux, ulcers, inflammatory bowel diseases, or cancer. ConclusionsFurther research is essential to deepen our understanding of coffee's impact on the digestive system and its systemic effects on the body. Additionally, promoting awareness of safe daily caffeine doses that can contribute to health is worthwhile.
导言咖啡是继水之后全球消费量第二大的饮料[1]。最近有关咖啡饮用效果的研究强调,如果坚持饮用推荐剂量的咖啡(通常为每天 2 至 5 杯,每天最多摄入 400 毫克咖啡因),会产生积极的效果。这一新发现凸显了适量饮用咖啡对我们整体健康和幸福的潜在益处。研究目的本研究旨在全面回顾有关饮用咖啡对胃肠道各方面影响的现有知识。结果最近的研究强调了咖啡的多种益处,包括帮助消化、加速转运以及在预防癌症方面的潜力。它能刺激胃酸分泌,促进胆汁和胰腺分泌,降低胆结石风险,促进大肠运动,调节肠道菌群。重要的是,咖啡并不是导致反流、溃疡、炎症性肠病或癌症等疾病的主要因素。结论进一步的研究对于加深我们对咖啡对消化系统的影响及其对人体的系统性影响的理解至关重要。此外,提高人们对有助于健康的每日咖啡因安全剂量的认识也是值得的。
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引用次数: 0
Romheld's Gastrocardiac Syndrome, diagnosing a complex of cardiologic and gastroenterologic symptoms 罗姆海尔德胃肠综合征,诊断心脏和胃肠症状的综合征
Pub Date : 2024-01-14 DOI: 10.12775/jehs.2024.53.001
Bartosz Bijata, Dawid Burek, Aleksandra Paszkowska, Aleksandra Kujawa, Urszula Matuszewska, Aleksandra Nykowska, Katarzyna Beutler
In clinical practice among cardiac patients, symptoms of palpitations diagnosed as premature beats or episodes of atrial fibrillation (AF) are very frequently reported. One of the most common diseases in the field of gastroenterology is gastroesophageal reflux disease (GERD) . However, it may happen that the coincidence of the above-mentioned disease entities may predispose to the development of arrhythmias. In this article we describe the case of a 65-year-old man, without previously diagnosed diseases, in whom a clear association of arrhythmias with gastrointestinal complaints was observed. The presence of a burning sensation in the lower sternal region and typical symptoms resulting from esophagitis aggravated by triggers allows us to suspect esophageal reflux disease. Diagnostic tests performed for concomitant cardiac diseases did not reveal an organic cause of the arrhythmia. The recurrent course of symptoms observed in the present case and the analysis of the cause-effect course made us to diagnose gastrointestinal syndrome, also referred to as Romheld's Syndrome.
在临床实践中,心脏病患者经常会出现被诊断为早搏或心房颤动(AF)发作的心悸症状。胃肠病学领域最常见的疾病之一是胃食管反流病(GERD)。然而,上述疾病实体的巧合也可能导致心律失常的发生。 在本文中,我们描述了一名 65 岁男性的病例,他之前没有确诊过任何疾病,但观察到心律失常与胃肠道不适明显相关。 由于胸骨下段出现烧灼感以及食管炎因诱因而加重的典型症状,我们怀疑他患有食管反流病。对并发心脏病进行的诊断性检查没有发现心律失常的器质性原因。在本病例中观察到的症状反复出现的过程以及对因果过程的分析使我们诊断为胃肠道综合征,也称为罗姆海尔德综合征。
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引用次数: 0
Impact of soy isoflavones on the prevention and treatment of obesity 大豆异黄酮对预防和治疗肥胖症的影响
Pub Date : 2024-01-14 DOI: 10.12775/jehs.2024.53.002
Karolina Wąsik, Sebastian Tomaszuk, Magda Wojtuś
Introduction and purpose:Currently, as the frequency of obesity is alarming, the role of many factors that could contribute in preventing and treating this condition are being researched, among them the certain food with beneficial health profiles - one of them is soybeans, specifically the isoflavones it contains. Populations that consume soy are known for lower risk of various disorders - among them obesity. The aim of this paper is to summarize the existing paper about the role of these bioactive components in the treatment of this condition. The search was conducted using PubMed and Google Scholarship databases.Brief description of the state of knowledge:Obesity is one of the leading challenges in today’s healthcare as it leads to various chronic diseases that are fraught in consequences. Current knowledge is pointing into the association between composition of the soy isoflavones and the lower risk of obesity. Results of the studies indicate that patients affected with obesity could benefit from introducing soy isoflavones into their diet along with other necessary modifications. Conclusions:Soy isoflavones are potential agents in the holistic obesity treatment. Consumption of isoflavones merits further recognition as foregoing results of conducted studies are pointing to its possibly meaningful role. It is worth mentioning that consumption of soy isoflavones is not only an anti-obese factor, but also presents various other health benefits and when consumed rationally poses no risk to human’s well being. We conclude that further studies would enable us to fully reveal the potential of those polyphenols.
引言和目的:目前,肥胖症的发病率令人担忧,人们正在研究许多有助于预防和治疗肥胖症的因素,其中包括某些有益健康的食物--大豆就是其中之一,特别是大豆所含的异黄酮。众所周知,食用大豆的人群患各种疾病的风险较低,其中包括肥胖症。本文旨在总结有关这些生物活性成分在治疗肥胖症方面作用的现有论文。知识现状简介:肥胖症是当今医疗保健领域的主要挑战之一,因为它会导致各种慢性疾病,后果不堪设想。目前的知识指向大豆异黄酮成分与降低肥胖风险之间的关联。研究结果表明,肥胖症患者可以从饮食中引入大豆异黄酮以及其他必要的调整中获益。结论:大豆异黄酮是全面治疗肥胖症的潜在药物。上述研究结果表明,大豆异黄酮可能具有重要作用,因此食用大豆异黄酮值得进一步认可。值得一提的是,食用大豆异黄酮不仅是一种抗肥胖因子,还能带来其他各种健康益处,合理食用不会对人体健康造成危害。我们的结论是,进一步的研究将使我们能够充分揭示这些多酚的潜力。
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引用次数: 0
The impact of ashwagandha on sleep quality, anxiety reduction, and stress lowering: comparative analysis of available studies 灰树花对睡眠质量、减少焦虑和减轻压力的影响:现有研究的比较分析
Pub Date : 2024-01-13 DOI: 10.12775/jehs.2024.52.015
Klaudia Malec
Introduction and objective: The increasing prevalence of sleep disorders, anxiety, and stress in contemporary society necessitates effective and accessible treatments. Ashwagandha - Withania somnifera (WS), an adaptogenic herb utilized in traditional Ayurvedic medicine, has gained significant attention in recent years for its potential to improve various aspects of health and well-being. This comprehensive review of the scientific literature aims to systematize the current scientific reports regarding the impact of Ashwagandha on enhancing sleep quality, reducing levels of anxiety and stress.   Material and Method: In this article, a review of publications available in the PubMed and Google Scholar databases was conducted, with an analysis of clinical and experimental studies focusing on methodology, participant demographics, dosage regimens, and tools for assessing sleep quality, anxiety, and stress levels. Articles were searched using English language terms: "ashwagandha," "Withania somnifera," "influence of sleep quality," "stress," "anxiety."   Conclusions: The scientific studies presented indicate the benefits of Ashwagandha supplementation in the context of improving sleep quality, reducing anxiety states, and stress. The results of various studies, including randomized controlled trials and systematic reviews, suggest that Ashwagandha may positively influence these health aspects through its action on the hypothalamic-pituitary-adrenal (HPA) axis11, modulation of neurotransmitters (GABA, serotonin)1, and antioxidative activity2.
导言和目标:在当代社会,睡眠障碍、焦虑和压力的发病率越来越高,因此需要有效且方便的治疗方法。芦根(Withania somnifera,WS)是传统阿育吠陀医学中使用的一种适应性草药,近年来因其改善各方面健康和福祉的潜力而备受关注。本科学文献综述旨在系统梳理目前有关芦根对提高睡眠质量、降低焦虑和压力水平的影响的科学报告。 材料与方法:本文对 PubMed 和 Google Scholar 数据库中的出版物进行了综述,重点分析了临床和实验研究的方法、参与者人口统计学、剂量方案以及评估睡眠质量、焦虑和压力水平的工具。文章使用英语术语进行搜索:"灰树叶"、"睡茄"、"对睡眠质量的影响"、"压力"、"焦虑"。 结论所介绍的科学研究表明,补充芦根可改善睡眠质量、减轻焦虑状态和压力。包括随机对照试验和系统综述在内的多项研究结果表明,灰树花可通过对下丘脑-垂体-肾上腺(HPA)轴11 的作用、对神经递质(GABA、5-羟色胺)1 的调节和抗氧化活性2 对这些健康方面产生积极影响。
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引用次数: 0
Etiology and Risk Factors for Strokes in the Pediatric Population 儿童脑卒中的病因和风险因素
Pub Date : 2024-01-13 DOI: 10.12775/jehs.2024.52.013
Lidia Bartoszek, Wojciech Kapłan, Jan Ostański, Karolina Zalewa, Dominika Orłowska, Rafał Świdziński, Bartosz Skorupski, Jakub Lipiec, Monika Rogowska, Joanna Olszak
Pediatric arterial ischemic stroke (AIS) and hemorrhagic stroke represent a relatively uncommon yet significant source of neurological challenges for neonates and children, resulting in outcomes such as hemiparesis, intellectual disabilities, and epilepsy. The etiology of pediatric strokes differs from the typical causes seen in adult stroke cases. Therefore, understanding the specific risk factors associated with strokes in children is crucial for facilitating early diagnosis, which regrettably remains frequently delayed. AIS incidence varies due to factors such as patient age, types of cerebral vascular diseases, other chronic conditions and geographic location. In this comprehensive review, we delve into the epidemiology, clinical manifestation and risk factors linked to arterial ischemic stroke and hemorrhagic stroke in neonates and children.
小儿动脉缺血性脑卒中(AIS)和出血性脑卒中是新生儿和儿童神经系统疾病中相对少见但却非常重要的病因,可导致偏瘫、智力障碍和癫痫等后果。小儿脑卒中的病因与成人脑卒中的典型病因不同。因此,了解与儿童脑卒中相关的特殊风险因素对于促进早期诊断至关重要,但遗憾的是,早期诊断仍经常被延误。AIS 发病率因患者年龄、脑血管疾病类型、其他慢性疾病和地理位置等因素而异。在这篇综述中,我们将深入探讨新生儿和儿童动脉缺血性卒中和出血性卒中的流行病学、临床表现和相关风险因素。
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引用次数: 0
Traumatic instability in the knee joint due to an anterior cruciate ligament (ACL) injury in a 23-year-old athlete 一名 23 岁运动员因前十字韧带(ACL)损伤导致膝关节创伤性失稳
Pub Date : 2024-01-13 DOI: 10.12775/jehs.2024.52.014
Nina Taborska, A. Martyka, Martyna Kubicka-Figiel
 Introduction  In this paper, we aim to present an analysis of the diagnostic, therapeutic, and rehabilitation procedures in a 23-year-old athlete with an anterior cruciate ligament (ACL) injury. The study includes the patient's medical history, circumstances of the injury, diagnostic and therapeutic procedures applied, as well as the course of postoperative rehabilitation. Objective  The objective of our study is to present the anatomy of the ACL, the typical mechanism of injury, and diagnostic and therapeutic possibilities. Methods  This is a retrospective study. The medical documentation and imaging studies were subjected to analysis. The analysis was complemented by a literature review based on publications in the English-language PubMed database. Results  The case involves a 23-year-old soccer player with an isolated ACL injury in the right knee joint. The case analysis highlights the challenges related to diagnosis and decision-making regarding therapeutic procedures. ACL reconstruction using the STG method and lateral tenodesis with the iliotibial band in combination with postoperative rehabilitation resulted in a positive outcome in terms of knee joint stability and return to sports. Conclusions  The review of this medical case underscores the importance of a personalized approach to each patient with an ACL injury, taking into account age, level of physical activity, and coexisting injuries within the knee joint. This allows for the correct decision on the best treatment method for the patient, facilitating a return to sports and minimizing the risk of complications.
引言 本文旨在分析一名 23 岁前十字韧带(ACL)损伤运动员的诊断、治疗和康复过程。研究内容包括患者的病史、受伤情况、应用的诊断和治疗程序以及术后康复过程。目的 我们的研究旨在介绍前交叉韧带的解剖结构、典型的损伤机制以及诊断和治疗的可能性。方法 这是一项回顾性研究。我们对医疗文件和影像学研究进行了分析。此外,还根据英文版 PubMed 数据库中的文献进行了文献综述。结果 本病例涉及一名 23 岁的足球运动员,右膝关节前交叉韧带孤立性损伤。病例分析强调了与诊断和治疗程序决策相关的挑战。采用 STG 方法和髂胫束外侧腱鞘切除术进行前交叉韧带重建,并结合术后康复治疗,在膝关节稳定性和恢复运动方面取得了积极成果。结论 通过对这一病例的回顾,强调了对每一位前交叉韧带损伤患者采取个性化治疗方法的重要性,要考虑到患者的年龄、运动水平以及膝关节内并存的损伤。这样才能正确决定最适合患者的治疗方法,帮助患者重返运动场并将并发症的风险降至最低。
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引用次数: 0
Health effects of cold water immersion and swimming and its influence on the human body 冷水浸泡和游泳对健康的影响及其对人体的影响
Pub Date : 2024-01-12 DOI: 10.12775/jehs.2024.52.011
J. Lipińska, Maria Kowalczuk, Łukasz Lipiński, Izabela Kopeć, Mikołaj Margas
Introduction            Immersing and swimming in cold water is an increasingly popular sport that has recently become a fashionable form of recreation in the winter months. People who regularly swim in cold water mention the many benefits associated with it.Aim of the study            This review aims to present the current state of knowledge about immersion and swimming in cold water and to answer questions about the impact of this phenomenon on the human body and its health benefits.Materials and methods            The PubMed database was used in this study.A literature review was conducted using the keywords “ice swimming,” “winter swimming,” “cold water swimming,” and “cold water immersion.”Results            Much research has been done on the effects of cold water swimming, both positive and negative. Ice swimming affects many systems of our body, including the circulatory system, the immune system, and the endocrine system, and also affects metabolic and mental changes in our body, as shown in the work below.Summary            A single immersion in cold water causes a stress reaction in the human body, while regular swimming in cold water causes the body to develop many positive physiological changes. Despite the benefits, it is still important to remember the risks involved, and more research should be done to minimize these dangers.
引言 在冷水中浸泡和游泳是一项越来越受欢迎的运动,最近已成为冬季的一种时尚娱乐方式。材料和方法 本研究使用了 PubMed 数据库,并以 "冰泳"、"冬泳"、"冷水游泳 "和 "冷水浸泡 "为关键词进行了文献综述。冰水游泳会影响我们身体的许多系统,包括循环系统、免疫系统和内分泌系统,还会影响我们身体的新陈代谢和精神变化,如下作品所示。小结 在冷水中浸泡一次会引起人体的应激反应,而经常在冷水中游泳则会使人体产生许多积极的生理变化。尽管有这些益处,但重要的是要记住其中的风险,应开展更多的研究来尽量减少这些危险。
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引用次数: 0
Gastric antral vascular ectasia, also known as watermelon stomach - diagnosis and treatment 胃前血管异位症,又称西瓜胃--诊断与治疗
Pub Date : 2024-01-12 DOI: 10.12775/jehs.2024.52.012
Karolina Jurasz, Dominika Podgórska, Ewa Rzeska, Miłosz Sanecki, Karolina Tomczyk, Natalia Chojnacka, Jakub Klarycki, Radosław Cymer
Gastric antral vascular ectasia (GAVE), also referred to as watermelon stomach is a rare disease accounting for about 4% of non-variceal upper gastrointestinal bleeding. It can manifest as occult bleeding requiring transfusion or acute gastrointestinal bleeding. This condition often coexists with liver cirrhosis, autoimmune diseases, heart failure, in patients post-bone marrow transplantation, or kidney failure. It is crucial to differentiate GAVE from portal hypertensive gastropathy (PHG), because despite a similar clinical presentation, the treatment for these conditions is different. Endoscopic diagnosis is necessary and in some cases, it may require further investigation and histopathological examination of the biopsy. Treatment is administered to patients with bleeding symptoms. Currently, the most commonly used treatment method is endoscopic thermal ablation using argon plasma coagulation. The focus of this work is to present essential information regarding the clinical picture, diagnosis and treatment of watermelon stomach.
胃前血管异位症(GAVE)又称西瓜胃,是一种罕见疾病,约占非静脉性上消化道出血的 4%。它可表现为需要输血的隐性出血或急性消化道出血。这种疾病通常与肝硬化、自身免疫性疾病、心力衰竭、骨髓移植后患者或肾衰竭并存。区分门静脉高压性胃炎(GAVE)和门静脉高压性胃病(PHG)至关重要,因为尽管临床表现相似,但治疗方法却不同。内窥镜诊断是必要的,在某些情况下,可能需要进一步检查和活组织病理学检查。对有出血症状的患者进行治疗。目前,最常用的治疗方法是利用氩等离子凝固技术进行内窥镜热消融。本文的重点是介绍有关西瓜胃的临床表现、诊断和治疗的基本信息。
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引用次数: 0
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Journal of Education, Health and Sport
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