Pub Date : 2024-04-19DOI: 10.12775/jehs.2024.66.005
Wojciech Mądry, Aleksandra Mazurkiewicz, Justyna Marcicka, Magdalena Kołodziej, Joanna Męczyńska, Nazarii Saiuk, Michał Andrzej Kozicz, Tomasz Seredyński, Adriana Wojciechowska, Weronika Salasa
Introduction Creatine, a supplement popular especially among athletes, is gaining increasive attention from scientists worldwide due to its potential health benefits, among other things, in the context of its anti-cancer application. Materials and methods The following review of studies is based on scientific articles from recent years available in the PubMed and Google Scholar databases. Key search terms included: "creatine", "creatine supplementation", "creatine in sports", "supplementation in sports", "creatine in cancer”. Results The literature review unequivocally demonstrates the beneficial impact of creatine supplementation on numerous health and athletic aspects. Creatine has been observed to have a positive effect on selected aspects of cancer treatment, such as reducing tumor mass, complementing the action of commonly used anticancer drugs, and slowing down the wasting associated with cancer diseases. Conclusion The promising results of the cited studies indicate that further research into creatine supplementation and its mechanisms of action is necessary. There is a need for further research on the positive impact of creatine supplementation in the treatment of cancer diseases. The significant potential of creatine supplementation may enable its inclusion in clinical practice in the future and the development of an effective therapeutic strategy based on it in the treatment of cancer diseases.
{"title":"Creatine - new hope in cancer treatment","authors":"Wojciech Mądry, Aleksandra Mazurkiewicz, Justyna Marcicka, Magdalena Kołodziej, Joanna Męczyńska, Nazarii Saiuk, Michał Andrzej Kozicz, Tomasz Seredyński, Adriana Wojciechowska, Weronika Salasa","doi":"10.12775/jehs.2024.66.005","DOIUrl":"https://doi.org/10.12775/jehs.2024.66.005","url":null,"abstract":"Introduction \u0000Creatine, a supplement popular especially among athletes, is gaining increasive attention from scientists worldwide due to its potential health benefits, among other things, in the context of its anti-cancer application. \u0000Materials and methods \u0000The following review of studies is based on scientific articles from recent years available in the PubMed and Google Scholar databases. Key search terms included: \"creatine\", \"creatine supplementation\", \"creatine in sports\", \"supplementation in sports\", \"creatine in cancer”. \u0000Results \u0000The literature review unequivocally demonstrates the beneficial impact of creatine supplementation on numerous health and athletic aspects. Creatine has been observed to have a positive effect on selected aspects of cancer treatment, such as reducing tumor mass, complementing the action of commonly used anticancer drugs, and slowing down the wasting associated with cancer diseases. \u0000Conclusion \u0000The promising results of the cited studies indicate that further research into creatine supplementation and its mechanisms of action is necessary. There is a need for further research on the positive impact of creatine supplementation in the treatment of cancer diseases. The significant potential of creatine supplementation may enable its inclusion in clinical practice in the future and the development of an effective therapeutic strategy based on it in the treatment of cancer diseases.","PeriodicalId":509157,"journal":{"name":"Journal of Education, Health and Sport","volume":" 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140684676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-19DOI: 10.12775/jehs.2024.66.008
Aleksandra Mazurkiewicz, Wojciech Mądry, Magdalena Kołodziej, Joanna Męczyńska, Nazarii Saiuk, Michał Andrzej Kozicz, Tomasz Seredyński, Adriana Wojciechowska, Justyna Marcicka, Weronika Salasa
Introduction Ashwagandha, a traditional Indian plant, is gaining increasive attention from scientists worldwide due to its potential health benefits, especially in the context of its antibacterial and anticancer properties. Aim of the study The aim of this review was to discuss recent findings regarding the impact of Withania Somnifera on antibacterial effect and its potential applications in anticancer therapy. Materials and methods: The paper was created based on the Pubmed and Google Scholar database. The literature was reviewed using the keywards: ,,Ashwagandha”, ,,Withania Somnifera”, ,,antibacterial ”, ,,anticancer”, ,,side effects”, ,,breats cancer”. Results Studies have confirmed Withania Somnifera, exhibits significant anticacterial and anticancer effects. It inhibits the growth of both Gram-negative and Gram-positive bacteria. Futhermore, it demonstrates anticancer activity, especially in breast cancer, by stimulating apoptosis, induction of cytotoxic effects on cancerous cells and increasing cell sensitivity to radiation. Conclusion Despite promising results, futher research on the benefits of Ashwagandha, particulary in the long term, is essential. There is growing need of more research of the potencial benefits of Ashwagandha in the treatment of various disorders including cancer and bacterial infections and to develop more effective therapeutic strategies. The need for large randomized studies comparing long term clinical effectiveness is emphasized
{"title":"Ashwagandha (Withania somnifera) - Its Antibacterial and Anticancer Activity","authors":"Aleksandra Mazurkiewicz, Wojciech Mądry, Magdalena Kołodziej, Joanna Męczyńska, Nazarii Saiuk, Michał Andrzej Kozicz, Tomasz Seredyński, Adriana Wojciechowska, Justyna Marcicka, Weronika Salasa","doi":"10.12775/jehs.2024.66.008","DOIUrl":"https://doi.org/10.12775/jehs.2024.66.008","url":null,"abstract":"Introduction \u0000Ashwagandha, a traditional Indian plant, is gaining increasive attention from scientists worldwide due to its potential health benefits, especially in the context of its antibacterial and anticancer properties. \u0000Aim of the study \u0000The aim of this review was to discuss recent findings regarding the impact of Withania Somnifera on antibacterial effect and its potential applications in anticancer therapy. \u0000Materials and methods: \u0000The paper was created based on the Pubmed and Google Scholar database. The literature was reviewed using the keywards: ,,Ashwagandha”, ,,Withania Somnifera”, ,,antibacterial ”, ,,anticancer”, ,,side effects”, ,,breats cancer”. \u0000Results \u0000Studies have confirmed Withania Somnifera, exhibits significant anticacterial and anticancer effects. It inhibits the growth of both Gram-negative and Gram-positive bacteria. Futhermore, it demonstrates anticancer activity, especially in breast cancer, by stimulating apoptosis, induction of cytotoxic effects on cancerous cells and increasing cell sensitivity to radiation. \u0000Conclusion \u0000Despite promising results, futher research on the benefits of Ashwagandha, particulary in the long term, is essential. There is growing need of more research of the potencial benefits of Ashwagandha in the treatment of various disorders including cancer and bacterial infections and to develop more effective therapeutic strategies. The need for large randomized studies comparing long term clinical effectiveness is emphasized","PeriodicalId":509157,"journal":{"name":"Journal of Education, Health and Sport","volume":" 69","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140683113","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-19DOI: 10.12775/jehs.2024.66.006
Magdalena Kołodziej, Michał Andrzej Kozicz, Nazarii Saiuk, Justyna Marcicka, Wojciech Mądry, Aleksandra Mazurkiewicz, Joanna Męczyńska, Tomasz Seredyński, Adriana Wojciechowska, Weronika Salasa
Introduction: Bladder cancer is one of the most common cancers in the world. There are two forms of bladder cancer: non-muscle invasive bladder cancer and muscle invasive bladder cancer. A common treatment method for non- muscle invasive bladder cancer is intravesical BCG (Mycobaterium bovis) therapy after radical tumor resection. It is estimated that half of patients will have an insufficient response to BCG treatment. Patients using this type of therapy also report side effects more and more often. Aim of the study: The aim of this article is to discuss the latest discoveries in the treatment of non-muscle invasive bladder cancer when BCG therapy is insufficient. Material and Methods: The paper was created based on the PubMed and Scholar database. The literature was reviewed using the key words: „bladder cancer”; „BCG”; „treatment”; „side effects”; „novel therapies”. Results: The research shows that novel therapies are effective and safe compared to the use of BCG. In such patients, atezolizumab, metformin or intravesical magnesium sulfate infusions may be used as an alternative. An innovative solution is the use of HIVEC - heated chemotherapy administered intravesically. There are also drugs that potentiate the action of BCG, making the therapy more effective. These include: sasanlimab and rapamycin. Due to the side effects experienced by patients, the use of intravesical BCG is often replaced with intravesical infusions of chemotherapy drugs. Conclusion: The research shows that novel therapies are effective compared to the use of BCG. Unfortunately, more research is needed to standardize the treatment of non-muscle invasive bladder cancer.
{"title":"Novel therapies of treating non-muscle invasive bladder cancer when BCG therapy turns out to be insufficient","authors":"Magdalena Kołodziej, Michał Andrzej Kozicz, Nazarii Saiuk, Justyna Marcicka, Wojciech Mądry, Aleksandra Mazurkiewicz, Joanna Męczyńska, Tomasz Seredyński, Adriana Wojciechowska, Weronika Salasa","doi":"10.12775/jehs.2024.66.006","DOIUrl":"https://doi.org/10.12775/jehs.2024.66.006","url":null,"abstract":"Introduction: Bladder cancer is one of the most common cancers in the world. There are two forms of bladder cancer: non-muscle invasive bladder cancer and muscle invasive bladder cancer. A common treatment method for non- muscle invasive bladder cancer is intravesical BCG (Mycobaterium bovis) therapy after radical tumor resection. It is estimated that half of patients will have an insufficient response to BCG treatment. Patients using this type of therapy also report side effects more and more often. Aim of the study: The aim of this article is to discuss the latest discoveries in the treatment of non-muscle invasive bladder cancer when BCG therapy is insufficient. Material and Methods: The paper was created based on the PubMed and Scholar database. The literature was reviewed using the key words: „bladder cancer”; „BCG”; „treatment”; „side effects”; „novel therapies”. Results: The research shows that novel therapies are effective and safe compared to the use of BCG. In such patients, atezolizumab, metformin or intravesical magnesium sulfate infusions may be used as an alternative. An innovative solution is the use of HIVEC - heated chemotherapy administered intravesically. There are also drugs that potentiate the action of BCG, making the therapy more effective. These include: sasanlimab and rapamycin. Due to the side effects experienced by patients, the use of intravesical BCG is often replaced with intravesical infusions of chemotherapy drugs. Conclusion: The research shows that novel therapies are effective compared to the use of BCG. Unfortunately, more research is needed to standardize the treatment of non-muscle invasive bladder cancer.","PeriodicalId":509157,"journal":{"name":"Journal of Education, Health and Sport","volume":" 31","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140685332","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-19DOI: 10.12775/jehs.2024.66.012
Tomasz Seredyński, Wojciech Mądry, Aleksandra Mazurkiewicz, Magdalena Kołodziej, Joanna Męczyńska, Nazarii Saiuk, Michał Andrzej Kozicz, Adriana Wojciechowska, Justyna Marcicka, Weronika Salasa
In recent years, there has been a growing interest in the interplay between lifestyle choices, particularly non-pharmacological methods, and their profound impact on gut health. This burgeoning interest is fuelled by a growing body of research highlighting the pivotal role of the gut microbiota in maintaining overall health and well-being. Aim of the study: The aim of this review is to explore the nexus between an optimal health-related choices and gut microbiota composition, highlighting the latest research findings and insights into how dietary patterns, physical activity, psychological stress and sleep quality influence microbial diversity and functionality. Materials and methods: A comprehensive examination of scientific literature available in the PubMed and Google Scholar databases was undertaken. The search strategy incorporated keywords such as "gut”, “gut microbiota”, “exercise”, “diet”, “stress” and “circadian rhythm” to identify relevant articles. Results: The literature review findings unequivocally reveal an increased diversity in the gut microbial community and a favourable balance between commensal and pathogenic bacteria, as well as overall gut health, including integrity and functionality, attributable to adherence to a healthy lifestyle. These findings highlight the intricate interplay between lifestyle factors and colon microbial composition. Conclusions: Although initial findings are encouraging, additional investigation into the potential impact of gut microbiota on health, particularly in the long term, is indispensable. Moreover, the limitations inherent in current research methodologies, such as small sample sizes, variability in study designs, and inconsistencies in findings, underscore the need for robust, well-controlled studies to validate and expand upon existing findings. Robust studies are necessary to develop targeted interventions for optimizing gut health.
近年来，人们越来越关注生活方式选择（尤其是非药物疗法）之间的相互作用及其对肠道健康的深远影响。越来越多的研究强调了肠道微生物群在维持整体健康和幸福方面的关键作用，这也激发了人们的兴趣。研究目的：本综述旨在探讨与健康相关的最佳选择与肠道微生物群组成之间的关系，重点介绍有关饮食模式、体育锻炼、心理压力和睡眠质量如何影响微生物多样性和功能的最新研究成果和见解。材料和方法：对 PubMed 和 Google Scholar 数据库中的科学文献进行了全面研究。搜索策略包括 "肠道"、"肠道微生物群"、"运动"、"饮食"、"压力 "和 "昼夜节律 "等关键词，以确定相关文章。结果文献综述结果明确显示，肠道微生物群落的多样性增加，共生菌和致病菌之间的平衡良好，坚持健康的生活方式可促进肠道的整体健康，包括完整性和功能性。这些发现凸显了生活方式因素与结肠微生物组成之间错综复杂的相互作用。结论：虽然初步研究结果令人鼓舞，但还需要进一步研究肠道微生物群对健康的潜在影响，尤其是长期影响。此外，目前的研究方法存在固有的局限性，如样本量小、研究设计多变、研究结果不一致等，这些都凸显了进行稳健、良好控制的研究来验证和扩展现有研究结果的必要性。要制定有针对性的干预措施来优化肠道健康，就必须进行稳健的研究。
{"title":"Unraveling the Influence of Lifestyle Choices on Microbiota Diversity – A Comprehensive Review","authors":"Tomasz Seredyński, Wojciech Mądry, Aleksandra Mazurkiewicz, Magdalena Kołodziej, Joanna Męczyńska, Nazarii Saiuk, Michał Andrzej Kozicz, Adriana Wojciechowska, Justyna Marcicka, Weronika Salasa","doi":"10.12775/jehs.2024.66.012","DOIUrl":"https://doi.org/10.12775/jehs.2024.66.012","url":null,"abstract":"In recent years, there has been a growing interest in the interplay between lifestyle choices, particularly non-pharmacological methods, and their profound impact on gut health. This burgeoning interest is fuelled by a growing body of research highlighting the pivotal role of the gut microbiota in maintaining overall health and well-being. Aim of the study: The aim of this review is to explore the nexus between an optimal health-related choices and gut microbiota composition, highlighting the latest research findings and insights into how dietary patterns, physical activity, psychological stress and sleep quality influence microbial diversity and functionality. Materials and methods: A comprehensive examination of scientific literature available in the PubMed and Google Scholar databases was undertaken. The search strategy incorporated keywords such as \"gut”, “gut microbiota”, “exercise”, “diet”, “stress” and “circadian rhythm” to identify relevant articles. Results: The literature review findings unequivocally reveal an increased diversity in the gut microbial community and a favourable balance between commensal and pathogenic bacteria, as well as overall gut health, including integrity and functionality, attributable to adherence to a healthy lifestyle. These findings highlight the intricate interplay between lifestyle factors and colon microbial composition. Conclusions: Although initial findings are encouraging, additional investigation into the potential impact of gut microbiota on health, particularly in the long term, is indispensable. Moreover, the limitations inherent in current research methodologies, such as small sample sizes, variability in study designs, and inconsistencies in findings, underscore the need for robust, well-controlled studies to validate and expand upon existing findings. Robust studies are necessary to develop targeted interventions for optimizing gut health.","PeriodicalId":509157,"journal":{"name":"Journal of Education, Health and Sport","volume":" 675","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140682139","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Introduction: The popularity of cosmetic treatments is increasing, including treatments using polydioxanone (PDO) threads. Among the various complications that PDO threads can cause are swelling, skin dimpling, paresthesia, thread visibility/palpability, infection, and thread extrusion. On the other hand, it is an alternative to surgical facelift. Purpose of work: To collect information on the complications after PDO threads for facial lifting. Summary: In the literature review, there were reported complications after PDO threads for facial lifting as edema, allergy, inflammation, infection, skin dimpling, contour irregularity, visible threads, hematoma, thread extrusion, and incomplete facial paralysis. Knowledge of complications after face lifting with PDO threads allows us to prepare for these side effects and act appropriately in the event of their occurrence, thus avoiding the long-term effects of the cosmetic procedure.
{"title":"Complications after polydioxanone threads (PDO) for facial lifting - a literature review","authors":"Karina Lewandowska, Izabela Staniszewska, Milena Baran, Magda Turczynowicz, Patrycja Retman","doi":"10.12775/jehs.2024.66.010","DOIUrl":"https://doi.org/10.12775/jehs.2024.66.010","url":null,"abstract":"Introduction: The popularity of cosmetic treatments is increasing, including treatments using polydioxanone (PDO) threads. Among the various complications that PDO threads can cause are swelling, skin dimpling, paresthesia, thread visibility/palpability, infection, and thread extrusion. On the other hand, it is an alternative to surgical facelift. \u0000Purpose of work: To collect information on the complications after PDO threads for facial lifting. \u0000Summary: In the literature review, there were reported complications after PDO threads for facial lifting as edema, allergy, inflammation, infection, skin dimpling, contour irregularity, visible threads, hematoma, thread extrusion, and incomplete facial paralysis. Knowledge of complications after face lifting with PDO threads allows us to prepare for these side effects and act appropriately in the event of their occurrence, thus avoiding the long-term effects of the cosmetic procedure.","PeriodicalId":509157,"journal":{"name":"Journal of Education, Health and Sport","volume":" 21","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140683916","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-18DOI: 10.12775/jehs.2024.66.002
Maciej Superson, Katarzyna Szmyt, Klaudia Wilk-Trytko, Julia Krasnoborska, Sylwia Samojedny, Katarzyna Szymańska, Kamil Walczak
Introduction and Purpose: In last years gene modification technologies such as CRISPR/Cas9 has had a revolutionary impact on the treatment of inherited diseases. Technologies developed from bacterial defense mechanisms, has become a basic tools in scientific research and medical therapies. In our article we provided an overview of applications of gene modifications technologies, directly focusing on CRISPR/Cas9, in genetic disease treatment. State of Knowledge: New applications of CRISPR/Cas9 are still being explored. Treating inherited diseases such as cystic fibrosis, Duchenne muscular dystrophy, thalassemia, hemophilia, Huntington's disease, Crigler-Najjar syndrome, sickle cell anemia, Marfan syndrome, and phenylketonuria, is feasible with this novel technique. A comparative analysis with other gene editing methods highlights CRISPR/Cas9's efficacy, ease of use, and multiplexing capabilities. Summary: CRISPR/Cas9 is a groundbreaking technology with broad applications in genetic research and therapy. Its ease of use, cost-effectiveness, and ability to target multiple genes simultaneously position it as a preferred method. However, there are some challenges associated with precision issues and ethical considerations in human embryo gene editing. As CRISPR/Cas9 continues to evolve, responsible application and ethical considerations are important for maximizing its potential in treatment of genetic diseases.
{"title":"Applications of gene modification technologies in the treatment of inherited diseases","authors":"Maciej Superson, Katarzyna Szmyt, Klaudia Wilk-Trytko, Julia Krasnoborska, Sylwia Samojedny, Katarzyna Szymańska, Kamil Walczak","doi":"10.12775/jehs.2024.66.002","DOIUrl":"https://doi.org/10.12775/jehs.2024.66.002","url":null,"abstract":"Introduction and Purpose: In last years gene modification technologies such as CRISPR/Cas9 has had a revolutionary impact on the treatment of inherited diseases. Technologies developed from bacterial defense mechanisms, has become a basic tools in scientific research and medical therapies. In our article we provided an overview of applications of gene modifications technologies, directly focusing on CRISPR/Cas9, in genetic disease treatment. \u0000 \u0000State of Knowledge: New applications of CRISPR/Cas9 are still being explored. Treating inherited diseases such as cystic fibrosis, Duchenne muscular dystrophy, thalassemia, hemophilia, Huntington's disease, Crigler-Najjar syndrome, sickle cell anemia, Marfan syndrome, and phenylketonuria, is feasible with this novel technique. A comparative analysis with other gene editing methods highlights CRISPR/Cas9's efficacy, ease of use, and multiplexing capabilities. \u0000 \u0000Summary: CRISPR/Cas9 is a groundbreaking technology with broad applications in genetic research and therapy. Its ease of use, cost-effectiveness, and ability to target multiple genes simultaneously position it as a preferred method. However, there are some challenges associated with precision issues and ethical considerations in human embryo gene editing. As CRISPR/Cas9 continues to evolve, responsible application and ethical considerations are important for maximizing its potential in treatment of genetic diseases.","PeriodicalId":509157,"journal":{"name":"Journal of Education, Health and Sport","volume":" 44","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140687192","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-18DOI: 10.12775/jehs.2024.66.003
Dominika Bachurska, Jakub Marek, Oliwia Grygorczuk, Zuzanna Czach
This narrative review critically examines the utilization of Selective Serotonin Reuptake Inhibitors (SSRIs) in managing coexisting depression and heart failure (HF), integrating findings from various studies, clinical trials, and observational data. SSRIs, pivotal in treating mood and anxiety disorders by elevating synaptic serotonin levels, have been observed to potentially impact cardiovascular health. Specifically, SSRIs like sertraline show promise in enhancing endothelial function and exerting anti-inflammatory effects, which are beneficial in conditions like HF with preserved ejection fraction (HFpEF). Furthermore, SSRIs demonstrate favorable outcomes in reducing platelet aggregation and modulating the renin-angiotensin-aldosterone system (RAAS), suggesting a multifaceted role in HF management. However, their safety profile, particularly concerning bleeding risks, QTc prolongation, and drug interactions, necessitates careful consideration. Despite theoretical and molecular evidence supporting SSRIs' beneficial effects in HF, clinical data remain inconclusive, highlighting the need for further research. This review aims to provide a comprehensive understanding of SSRIs' effectiveness, safety, and potential benefits in treating depression and HF, offering insights for evidence-based decision-making and future research directions.
{"title":"The Treatment of Depression in Patients with Heart Failure","authors":"Dominika Bachurska, Jakub Marek, Oliwia Grygorczuk, Zuzanna Czach","doi":"10.12775/jehs.2024.66.003","DOIUrl":"https://doi.org/10.12775/jehs.2024.66.003","url":null,"abstract":"This narrative review critically examines the utilization of Selective Serotonin Reuptake Inhibitors (SSRIs) in managing coexisting depression and heart failure (HF), integrating findings from various studies, clinical trials, and observational data. SSRIs, pivotal in treating mood and anxiety disorders by elevating synaptic serotonin levels, have been observed to potentially impact cardiovascular health. Specifically, SSRIs like sertraline show promise in enhancing endothelial function and exerting anti-inflammatory effects, which are beneficial in conditions like HF with preserved ejection fraction (HFpEF). Furthermore, SSRIs demonstrate favorable outcomes in reducing platelet aggregation and modulating the renin-angiotensin-aldosterone system (RAAS), suggesting a multifaceted role in HF management. However, their safety profile, particularly concerning bleeding risks, QTc prolongation, and drug interactions, necessitates careful consideration. Despite theoretical and molecular evidence supporting SSRIs' beneficial effects in HF, clinical data remain inconclusive, highlighting the need for further research. This review aims to provide a comprehensive understanding of SSRIs' effectiveness, safety, and potential benefits in treating depression and HF, offering insights for evidence-based decision-making and future research directions.","PeriodicalId":509157,"journal":{"name":"Journal of Education, Health and Sport","volume":" 17","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140690458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-17DOI: 10.12775/jehs.2024.66.001
Jakub Kawka, Alicja Baranowska, Katarzyna Baranowska, Filip Czyżewski, Kinga Filipek, Michał Muciek, Sebastian Mrugała, Waldemar Mrugała, Bartosz Skierkowski, Natalia Zalewska
Glaucoma is a group of progressive neuropathies of the optic nerve leading to the destructionof retinal ganglion cells and their axons. It is the leading cause of irreversible blindnessworldwide, affecting over 70 million people residing in various geographical regions. Thisdisease ranks second among the causes of blindness in patients. Up to 40% of them lose theirvision within the first year of diagnosis.(1) The most common type of glaucoma affectingophthalmic patients is open-angle glaucoma, in which the iridocorneal angle is notpathologically altered, but there is an elevation of intraocular pressure due to abnormal fluidflow within the eye. The main cause of this disease is obstruction of aqueous humor outflowfrom the eye and its excessive production. Although the exact mechanism of glaucoma is notfully understood yet, several risk factors have been identified, including high intraocularpressure (IOP), age, and genetics. Materials and Methods: Review and summary of research studies available in open-sourceformat on Google Scholar, PubMed.Conclusions: There is ample evidence confirming the impact of food products on the risk ofdeveloping glaucoma or exacerbating its symptoms. However, further research is necessary todetermine the extent of their interference with this disease entity.
青光眼是一组导致视网膜神经节细胞及其轴突破坏的进行性视神经病变。它是导致全球不可逆转性失明的主要原因，影响着居住在不同地区的 7000 多万人。这种疾病在导致患者失明的原因中排名第二。(1)眼科患者最常见的青光眼类型是开角型青光眼，即虹膜角膜无病理改变，但由于眼内液体流动异常导致眼压升高。这种疾病的主要病因是眼内房水流出受阻和房水分泌过多。虽然青光眼的确切机制尚未完全明了，但已确定了几个风险因素，包括高眼压、年龄和遗传：对 Google Scholar、PubMed 上开源格式的研究进行回顾和总结：有大量证据证实，食品对青光眼发病风险或加重青光眼症状有影响。然而，要确定食品对这种疾病的影响程度，还需要进一步的研究。
{"title":"The impact of eating disorders on glaucoma","authors":"Jakub Kawka, Alicja Baranowska, Katarzyna Baranowska, Filip Czyżewski, Kinga Filipek, Michał Muciek, Sebastian Mrugała, Waldemar Mrugała, Bartosz Skierkowski, Natalia Zalewska","doi":"10.12775/jehs.2024.66.001","DOIUrl":"https://doi.org/10.12775/jehs.2024.66.001","url":null,"abstract":"Glaucoma is a group of progressive neuropathies of the optic nerve leading to the destructionof retinal ganglion cells and their axons. It is the leading cause of irreversible blindnessworldwide, affecting over 70 million people residing in various geographical regions. Thisdisease ranks second among the causes of blindness in patients. Up to 40% of them lose theirvision within the first year of diagnosis.(1) The most common type of glaucoma affectingophthalmic patients is open-angle glaucoma, in which the iridocorneal angle is notpathologically altered, but there is an elevation of intraocular pressure due to abnormal fluidflow within the eye. The main cause of this disease is obstruction of aqueous humor outflowfrom the eye and its excessive production. Although the exact mechanism of glaucoma is notfully understood yet, several risk factors have been identified, including high intraocularpressure (IOP), age, and genetics.\u0000Materials and Methods: Review and summary of research studies available in open-sourceformat on Google Scholar, PubMed.Conclusions: There is ample evidence confirming the impact of food products on the risk ofdeveloping glaucoma or exacerbating its symptoms. However, further research is necessary todetermine the extent of their interference with this disease entity.","PeriodicalId":509157,"journal":{"name":"Journal of Education, Health and Sport","volume":" 116","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140692503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-15DOI: 10.12775/jehs.2024.65.012
Marta Barg, Julia Biały-Karbowniczek, Aleksandra Jędrasek, Klaudia Wojtyła
Introduction: Migraine remains one of the most prevalent chronic neurological conditions that significantly impacts the quality of life. The treatment aims to help with the symptoms and prevent further attacks. There are several pharmacological methods, but because of their side effects, sometimes lower-than-expected effectiveness, costs, and long-term dependency, non-pharmacological approaches have gained popularity. Review methods: We conducted our study as a literature review, with data gathered via PubMed and Embase.The state of knowledge: Managing migraine is hard to achieve based only on pharmacological therapy. Recently, the development of alternative approaches, such as cognitive behavioral therapy, acupuncture, or butterbur, has been observed. Many studies try to assess its effectiveness. Biofeedback is a promising treatment method, however, it is expensive and requires special equipment. Aerobic training is essential in the prevention and therapy of many illnesses and proper intensity can be helpful with migraines, while yoga is a great lower-intensity option. Conclusions: Alternative methods may be a great alternative or support in migraine management. However, there is still a need for standardized investigations to evaluate effectiveness and safety.
{"title":"Beyond conventional therapies - an overview of the alternative approaches in migraine management","authors":"Marta Barg, Julia Biały-Karbowniczek, Aleksandra Jędrasek, Klaudia Wojtyła","doi":"10.12775/jehs.2024.65.012","DOIUrl":"https://doi.org/10.12775/jehs.2024.65.012","url":null,"abstract":"Introduction: Migraine remains one of the most prevalent chronic neurological conditions that significantly impacts the quality of life. The treatment aims to help with the symptoms and prevent further attacks. There are several pharmacological methods, but because of their side effects, sometimes lower-than-expected effectiveness, costs, and long-term dependency, non-pharmacological approaches have gained popularity. Review methods: We conducted our study as a literature review, with data gathered via PubMed and Embase.The state of knowledge: Managing migraine is hard to achieve based only on pharmacological therapy. Recently, the development of alternative approaches, such as cognitive behavioral therapy, acupuncture, or butterbur, has been observed. Many studies try to assess its effectiveness. Biofeedback is a promising treatment method, however, it is expensive and requires special equipment. Aerobic training is essential in the prevention and therapy of many illnesses and proper intensity can be helpful with migraines, while yoga is a great lower-intensity option. Conclusions: Alternative methods may be a great alternative or support in migraine management. However, there is still a need for standardized investigations to evaluate effectiveness and safety.","PeriodicalId":509157,"journal":{"name":"Journal of Education, Health and Sport","volume":"57 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140700338","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-15DOI: 10.12775/jehs.2024.65.015
Karen Głogowska, Mikołaj Wojtas, Julia Piątkiewicz, Maria Krzyżanowska, Marcin Kapica, Gabriela Nowak, Aleksandra Żmijewska, Mateusz Sztybór, Monika Maleszewska, Wojciech Kopacz
Introduction The rising prevalence of electronic cigarette (e-cigarette) use has prompted concerns regarding its potential health implications. While much attention has focused on respiratory and cardiovascular effects, injuries, oral trauma, and bone fractures linked to e-cigarette use have received less scrutiny. This paper aims to comprehensively review the landscape of injuries, oral trauma, and bone fractures induced by e-cigarettes, shedding light on this underexplored facet of e-cigarette-related harm. Material and Methods This literature review has analyzed 16 papers. Inclusion criteria: researches and case reports published after 2015. PubMed and Google Scholar has been searched to identify the papers. Analysis of the Literature Existing literature suggests a growing incidence of injuries, oral trauma, and bone fractures associated with e-cigarette use, albeit with limited systematic investigation. Mechanisms underlying these injuries range from device malfunctions to inadvertent impacts during use. Case reports highlight a spectrum of injuries, including oral burns, dental trauma, and skeletal fractures, often involving the face and mouth regions. Conclusions Despite the lack of comprehensive epidemiological data emerging evidence underscores the need for heightened awareness and preventive measures to mitigate e-cigarette-related injuries. Enhanced education, regulation of e-cigarette devices, and promotion of safer usage practices are crucial steps towards reducing the burden of e-cigarette-related harm on oral and skeletal health.
导言：电子烟使用的日益普及引发了人们对其潜在健康影响的关注。尽管人们的注意力主要集中在对呼吸系统和心血管系统的影响上，但与使用电子烟有关的伤害、口腔创伤和骨折却较少受到关注。本文旨在全面回顾电子烟引起的伤害、口腔创伤和骨折的情况，揭示电子烟相关危害中这一未被充分探索的方面。纳入标准：2015 年后发表的研究和病例报告。检索了 PubMed 和 Google Scholar 以确定论文。文献分析现有文献表明，与使用电子烟相关的伤害、口腔创伤和骨折的发生率越来越高，尽管系统性调查有限。造成这些伤害的机制包括设备故障和使用过程中的意外撞击。病例报告强调了一系列伤害，包括口腔烧伤、牙外伤和骨骼骨折，通常涉及面部和口腔区域。结论尽管缺乏全面的流行病学数据，但新出现的证据强调了提高意识和采取预防措施以减轻电子烟相关伤害的必要性。加强教育、规范电子烟设备和推广更安全的使用方法是减轻电子烟相关伤害对口腔和骨骼健康造成的负担的关键步骤。
{"title":"The Impact of E-Cigarettes on Oral Injuries and Bone Fractures","authors":"Karen Głogowska, Mikołaj Wojtas, Julia Piątkiewicz, Maria Krzyżanowska, Marcin Kapica, Gabriela Nowak, Aleksandra Żmijewska, Mateusz Sztybór, Monika Maleszewska, Wojciech Kopacz","doi":"10.12775/jehs.2024.65.015","DOIUrl":"https://doi.org/10.12775/jehs.2024.65.015","url":null,"abstract":"Introduction\u0000The rising prevalence of electronic cigarette (e-cigarette) use has prompted concerns regarding its potential health implications. While much attention has focused on respiratory and cardiovascular effects, injuries, oral trauma, and bone fractures linked to e-cigarette use have received less scrutiny. This paper aims to comprehensively review the landscape of injuries, oral trauma, and bone fractures induced by e-cigarettes, shedding light on this underexplored facet of e-cigarette-related harm.\u0000Material and Methods\u0000This literature review has analyzed 16 papers. Inclusion criteria: researches and case reports published after 2015. PubMed and Google Scholar has been searched to identify the papers.\u0000 Analysis of the Literature\u0000Existing literature suggests a growing incidence of injuries, oral trauma, and bone fractures associated with e-cigarette use, albeit with limited systematic investigation. Mechanisms underlying these injuries range from device malfunctions to inadvertent impacts during use. Case reports highlight a spectrum of injuries, including oral burns, dental trauma, and skeletal fractures, often involving the face and mouth regions.\u0000Conclusions\u0000Despite the lack of comprehensive epidemiological data emerging evidence underscores the need for heightened awareness and preventive measures to mitigate e-cigarette-related injuries. Enhanced education, regulation of e-cigarette devices, and promotion of safer usage practices are crucial steps towards reducing the burden of e-cigarette-related harm on oral and skeletal health.","PeriodicalId":509157,"journal":{"name":"Journal of Education, Health and Sport","volume":"17 S2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140700656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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