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Health Care Discrimination and Care Avoidance Due to Patient-Clinician Identity Discordance Among Sexual and Gender Minority Adults. 性少数群体和性别少数群体成年人因患者与医生身份不一致而产生的医疗歧视和医疗回避。
IF 4.4 2区 医学 Q1 MEDICINE, GENERAL & INTERNAL Pub Date : 2024-07-01 DOI: 10.1370/afm.3130
Michael Liu, Vishal R Patel, Sahil Sandhu, Sari Reisner, Alex S Keuroghlian

Sexual and gender minority (SGM) adults experience poor health outcomes, in part due to frequent avoidance of necessary health care. Little is known, however, about factors contributing to patterns of health care utilization in this population. Using national data from the All of Us Research Program, this study evaluated the prevalence of care avoidance due to patient-clinician identity discordance (PCID) and its association with health care discrimination among SGM adults. Sexual minority (20.0% vs 9.4%; adjusted rate ratio [aRR] = 1.58; 95% CI, 1.49-1.67, P <0.001) and gender minority adults (34.4% vs 10.3%; aRR = 2.00; 95% CI, 1.79-2.21, P <0.001) were significantly more likely than their non-SGM counterparts to report care avoidance due to PCID. Exposure to health care discrimination was also more prevalent in this population and was dose-dependently associated with significantly higher rates of PCID-based care avoidance. Study findings highlight the importance of diversifying the health care workforce, expanding SGM-related clinical training, and preventing health care discrimination against SGM patients.

性与性别少数群体(SGM)成年人的健康状况较差,部分原因是他们经常逃避必要的医疗保健。然而,人们对导致这一人群利用医疗保健模式的因素知之甚少。本研究利用 "我们所有人研究计划"(All of Us Research Program)的全国性数据,评估了性少数群体成人中因患者与医生身份不一致(PCID)而避免就医的普遍程度及其与医疗歧视之间的关联。性少数群体(20.0% vs 9.4%;调整后比率比 [aRR] = 1.58;95% CI,1.49-1.67,P P
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引用次数: 0
Stop Testing Black Babies! 停止测试黑人婴儿
IF 4.4 2区 医学 Q1 MEDICINE, GENERAL & INTERNAL Pub Date : 2024-07-01 DOI: 10.1370/afm.3143
Cleavon Covington, Elisha Jackson, Kendall M Campbell, Judy C Washington, José E Rodríguez
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引用次数: 0
Structural Racism in Newborn Drug Testing: Perspectives of Health Care and Child Protective Services Professionals. 新生儿药物检测中的结构性种族主义:医疗保健和儿童保护服务专业人员的观点。
IF 4.4 2区 医学 Q1 MEDICINE, GENERAL & INTERNAL Pub Date : 2024-07-01 DOI: 10.1370/afm.3139
Carol Shetty, Lauren Oshman, Amanda Costa, Victoria Waidley, Emily Madlambayan, Madgean Joassaint, Katharine McCabe, Courtney Townsel, Justine P Wu, Christopher J Frank, P Paul Chandanabhumma

Purpose: Black birthing parents and their newborns disproportionately experience newborn drug testing for prenatal substance exposure by health care professionals (HCPs), which contributes to Child Protective Services (CPS) reporting, family separation, and termination of parental rights. This qualitative study aims to interrogate dominant power structures by exploring knowledge, attitudes, and experiences of HCPs and CPS professionals regarding the influence of structural racism on inequities in newborn drug testing practices.

Methods: We conducted semistructured interviews with 30 physicians, midwives, nurses, social workers, and CPS professionals guided by an explanatory framework, and conducted inductive, reflexive thematic analysis.

Results: We identified 3 primary themes: (1) levels of racism beyond the hospital structure contributed to higher rates of drug testing for Black newborns; (2) inconsistent hospital policies led to racialized application of state law and downstream CPS reporting; and (3) health care professionals knowledge of the benefits and disproportionate harms of CPS reporting on Black families influenced their decision making.

Conclusion: Health care professionals recognized structural racism as a driver of disproportionate newborn drug testing. Lack of knowledge and skill limitations of HCPs were barriers to dismantling power structures, thus impeding systems-level change. Institutional changes should shift focus from biologic testing and reporting to supporting the mutual needs of birthing parent and child through family-centered substance use treatment. State and federal policy changes are needed to ensure health equity for Black families and eliminate reporting to CPS for prenatal substance exposure when no concern for child abuse and neglect exists.

目的:黑人生育父母和他们的新生儿在接受新生儿药物检测时,过多地受到医疗保健专业人员(HCPs)产前药物暴露的影响,这导致了儿童保护服务(CPS)报告、家庭分离和父母权利终止。本定性研究旨在通过探讨医疗保健专业人员和儿童保护服务专业人员对结构性种族主义对新生儿药物检测实践中的不平等现象的影响的认识、态度和经验,对主流权力结构进行质询:在解释性框架的指导下,我们对 30 名医生、助产士、护士、社工和 CPS 专业人员进行了半结构式访谈,并进行了归纳、反思性主题分析:我们确定了 3 个主要主题:(1)医院结构之外的种族主义水平导致黑人新生儿药物检测率较高;(2)不一致的医院政策导致州法律和下游 CPS 报告的种族化应用;以及(3)医护专业人员对 CPS 报告对黑人家庭的益处和不成比例的伤害的了解影响了他们的决策:医护专业人员认识到结构性种族主义是导致新生儿药物检测比例过高的原因之一。医护人员知识的匮乏和技能的局限性阻碍了权力结构的瓦解,从而阻碍了制度层面的变革。制度变革应将重点从生物检测和报告转移到通过以家庭为中心的药物使用治疗来支持分娩父母和婴儿的共同需求。需要改变州和联邦政策,以确保黑人家庭的健康公平,并在不存在虐待和忽视儿童问题的情况下,消除向儿童保护机构报告产前药物暴露的做法。
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引用次数: 0
Dutch Translation and Psychometric Evaluation of the Person-Centered Primary Care Measure. 以人为本的初级保健测量》的荷兰语翻译和心理测量评估。
IF 4.4 2区 医学 Q1 MEDICINE, GENERAL & INTERNAL Pub Date : 2024-07-01 DOI: 10.1370/afm.3135
Talitha Schut, Bernard van de Meeberg, Peter Lucassen, Rebecca S Etz, Maria van den Muijsenbergh, Reinier P Akkermans, Tim C. Olde Hartman

Purpose: Person-centered care is foundational to good quality primary care and has positive effects on health outcomes and patient satisfaction. The Person-Centered Primary Care Measure (PCPCM) is a recently developed, patient-reported survey able to assess person-centeredness and has demonstrated strong validity and reliability. Little is known, however, about the feasibility of the PCPCM in non-English-speaking settings. We aimed to translate the questionnaire into Dutch, psychometrically evaluate the translated version, and ensure its feasibility for patients in Dutch primary care.

Methods: We translated the PCPCM into Dutch using forward-backward translations. We conducted psychometric evaluations to ensure its feasibility among Dutch-speaking primary care patients, with special attention to low literacy populations. Next, we assessed structural validity, convergent validity using the Quality of Care Through the Patient's Eyes (QUOTE) questionnaire, and internal consistency in a cross-sectional study in primary care.

Results: Translation and adaptation for low literacy populations required 4 iterations. In 4 general practices, 205 patients completed the survey. Confirmatory factor analyses could not confirm the 1-factor solution. The 3-factor solution was found to be a more optimal fit: comprehensiveness of care, personal relation, and contextual care. Internal reliability was high (Cronbach's α were 0.82, 0.73, and 0.86, respectively). We found a strong correlation between the total PCPCM and QUOTE scores (Spearman's ρ = 0.65, P <.001), indicating good convergent validity.

Conclusion: The Dutch version of the PCPCM has acceptable validity and reliability for measuring person-centeredness in primary care among Dutch-speaking populations including those with low literacy.

目的:以人为本的护理是优质初级保健的基础,对健康结果和患者满意度有积极影响。以人为本的初级保健测量(PCPCM)是最近开发的一项由患者报告的调查,能够评估以人为本的程度,并已证明具有很强的有效性和可靠性。然而,人们对 PCPCM 在非英语环境中的可行性知之甚少。我们的目的是将该问卷翻译成荷兰语,对翻译版本进行心理计量学评估,并确保其在荷兰初级医疗机构的可行性:方法:我们采用向前向后翻译法将 PCPCM 翻译成荷兰语。我们进行了心理测量评估,以确保其在讲荷兰语的初级医疗患者中的可行性,并特别关注低文化程度人群。接下来,我们使用 "患者眼中的护理质量"(QUOTE)问卷评估了结构效度、收敛效度,并在一项初级保健横断面研究中评估了内部一致性:结果:针对低文化水平人群的翻译和调整需要反复进行 4 次。在 4 家全科诊所,205 名患者完成了调查。确认性因素分析无法确认单因素解决方案。结果发现,3 个因子的解决方案更为理想:护理的全面性、个人关系和情境护理。内部信度很高(Cronbach's α 分别为 0.82、0.73 和 0.86)。我们发现,PCPCM 总分与 QUOTE 分数之间存在很强的相关性(Spearman's ρ = 0.65,P 结论):荷兰语版本的 PCPCM 具有可接受的有效性和可靠性,可用于测量包括识字率较低人群在内的讲荷兰语人群在初级保健中以人为中心的程度。
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引用次数: 0
Scenario-Based Discussion: Using Adult Learning Theory to Improve Discussion on Lifestyle Medicine for Healthy Adults. 基于情景的讨论:利用成人学习理论改进有关健康成人生活方式医学的讨论。
IF 4.4 2区 医学 Q1 MEDICINE, GENERAL & INTERNAL Pub Date : 2024-07-01 DOI: 10.1370/afm.3118
Andrew Baumgartner, Jill Tirabassi, Matthew Doyle
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引用次数: 0
Action Guides Offer Steps Toward Health Equity. 行动指南提供了实现健康平等的步骤。
IF 4.4 2区 医学 Q1 MEDICINE, GENERAL & INTERNAL Pub Date : 2024-07-01 DOI: 10.1370/afm.3155
News Staff
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引用次数: 0
Post-COVID Conditions in US Primary Care: A PRIME Registry Comparison of Patients With COVID-19, Influenza-Like Illness, and Wellness Visits. 美国初级保健中的 COVID 后疾病:对 COVID-19 患者、流感样疾病患者和健康就诊者的 PRIME 登记比较。
IF 4.4 2区 医学 Q1 MEDICINE, GENERAL & INTERNAL Pub Date : 2024-07-01 DOI: 10.1370/afm.3131
Esther E Velásquez, Neil S Kamdar, David H Rehkopf, Sharon Saydah, Lara Bull-Otterson, Shiying Hao, Ayin Vala, Isabella Chu, Andrew W Bazemore, Robert L Phillips, Tegan Boehmer

Purpose: COVID-19 is a condition that can lead to other chronic conditions. These conditions are frequently diagnosed in the primary care setting. We used a novel primary care registry to quantify the burden of post-COVID conditions among adult patients with a COVID-19 diagnosis across the United States.

Methods: We used the American Family Cohort, a national primary care registry, to identify study patients. After propensity score matching, we assessed the prevalence of 17 condition categories individually and cumulatively, comparing patients having COVID-19 in 2020-2021 with (1) historical control patients having influenza-like illness in 2018 and (2) contemporaneous control patients seen for wellness or preventive visits in 2020-2021.

Results: We identified 28,215 patients with a COVID-19 diagnosis and 235,953 historical control patients with influenza-like illness. The COVID-19 group had higher prevalences of breathing difficulties (4.2% vs 1.9%), type 2 diabetes (12.0% vs 10.2%), fatigue (3.9% vs 2.2%), and sleep disturbances (3.5% vs 2.4%). There were no differences, however, in the postdiagnosis monthly trend in cumulative morbidity between the COVID-19 patients (trend = 0.026; 95% CI, 0.025-0.027) and the patients with influenza-like illness (trend = 0.026; 95% CI, 0.023-0.027). Relative to contemporaneous wellness control patients, COVID-19 patients had higher prevalences of breathing difficulties and type 2 diabetes.

Conclusions: Our findings show a moderate burden of post-COVID conditions in primary care, including breathing difficulties, fatigue, and sleep disturbances. Based on clinical registry data, the prevalence of post-COVID conditions in primary care practices is lower than that reported in subspecialty and hospital settings.

目的:COVID-19 是一种可导致其他慢性疾病的病症。这些疾病经常在初级医疗机构得到诊断。我们利用一个新颖的初级保健登记系统对全美确诊为 COVID-19 的成年患者的 COVID 后疾病负担进行了量化:方法:我们利用美国家庭队列(American Family Cohort)这一全国初级医疗登记系统来识别研究对象。经过倾向得分匹配后,我们评估了 17 种疾病类别的单独和累积患病率,并将 2020-2021 年 COVID-19 患者与(1)2018 年患有流感样疾病的历史对照组患者和(2)2020-2021 年接受健康或预防性就诊的同期对照组患者进行了比较:我们确定了 28215 名诊断为 COVID-19 的患者和 235953 名患有流感样疾病的历史对照组患者。COVID-19 组患者呼吸困难(4.2% 对 1.9%)、2 型糖尿病(12.0% 对 10.2%)、疲劳(3.9% 对 2.2%)和睡眠障碍(3.5% 对 2.4%)的发病率较高。然而,COVID-19 患者(趋势 = 0.026;95% CI,0.025-0.027)和流感样疾病患者(趋势 = 0.026;95% CI,0.023-0.027)在诊断后每月累积发病率趋势方面没有差异。与同期健康对照患者相比,COVID-19 患者的呼吸困难和 2 型糖尿病发病率更高:我们的研究结果表明,COVID 后患者在初级保健中的负担适中,包括呼吸困难、疲劳和睡眠障碍。根据临床登记数据,初级医疗机构中 COVID 后疾病的患病率低于亚专科和医院环境中的患病率。
{"title":"Post-COVID Conditions in US Primary Care: A PRIME Registry Comparison of Patients With COVID-19, Influenza-Like Illness, and Wellness Visits.","authors":"Esther E Velásquez, Neil S Kamdar, David H Rehkopf, Sharon Saydah, Lara Bull-Otterson, Shiying Hao, Ayin Vala, Isabella Chu, Andrew W Bazemore, Robert L Phillips, Tegan Boehmer","doi":"10.1370/afm.3131","DOIUrl":"10.1370/afm.3131","url":null,"abstract":"<p><strong>Purpose: </strong>COVID-19 is a condition that can lead to other chronic conditions. These conditions are frequently diagnosed in the primary care setting. We used a novel primary care registry to quantify the burden of post-COVID conditions among adult patients with a COVID-19 diagnosis across the United States.</p><p><strong>Methods: </strong>We used the American Family Cohort, a national primary care registry, to identify study patients. After propensity score matching, we assessed the prevalence of 17 condition categories individually and cumulatively, comparing patients having COVID-19 in 2020-2021 with (1) historical control patients having influenza-like illness in 2018 and (2) contemporaneous control patients seen for wellness or preventive visits in 2020-2021.</p><p><strong>Results: </strong>We identified 28,215 patients with a COVID-19 diagnosis and 235,953 historical control patients with influenza-like illness. The COVID-19 group had higher prevalences of breathing difficulties (4.2% vs 1.9%), type 2 diabetes (12.0% vs 10.2%), fatigue (3.9% vs 2.2%), and sleep disturbances (3.5% vs 2.4%). There were no differences, however, in the postdiagnosis monthly trend in cumulative morbidity between the COVID-19 patients (trend = 0.026; 95% CI, 0.025-0.027) and the patients with influenza-like illness (trend = 0.026; 95% CI, 0.023-0.027). Relative to contemporaneous wellness control patients, COVID-19 patients had higher prevalences of breathing difficulties and type 2 diabetes.</p><p><strong>Conclusions: </strong>Our findings show a moderate burden of post-COVID conditions in primary care, including breathing difficulties, fatigue, and sleep disturbances. Based on clinical registry data, the prevalence of post-COVID conditions in primary care practices is lower than that reported in subspecialty and hospital settings.</p>","PeriodicalId":50973,"journal":{"name":"Annals of Family Medicine","volume":"22 4","pages":"279-287"},"PeriodicalIF":4.4,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11268691/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141749623","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Shoeshine Stand and the Renaissance of Primary Care. 擦鞋摊和初级保健的文艺复兴。
IF 4.4 2区 医学 Q1 MEDICINE, GENERAL & INTERNAL Pub Date : 2024-07-01 DOI: 10.1370/afm.3137
John J Frey

Over the past century, family physicians have moved from small independently owned practices, many of them solo, to being employed by large hospital systems, corporate entities, or health systems. Today, almost three-quarters of all physicians are employed and the highest percentage of employed physicians are family physicians.This essay contrasts the elements of independent practice with employed practice as part of what has been lost in the past half century, but what might be regained if physicians demanded more autonomy and control over their practices.

在过去的一个世纪里,家庭医生从独立开业的小诊所(其中许多是个体诊所)转变为受雇于大型医院系统、公司实体或医疗系统。今天,几乎四分之三的医生都是受雇于人,而受雇医生中比例最高的是家庭医生。这篇文章对比了独立执业和受雇执业的要素,作为过去半个世纪中失去的东西的一部分,但如果医生要求对自己的执业有更多的自主权和控制权,可能会重新获得什么。
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引用次数: 0
Fifty Years of Connection: Characterizing the Social Network of a Primary Care Research Organization. 五十年的联系:基层医疗研究机构社会网络的特征。
IF 4.4 2区 医学 Q1 MEDICINE, GENERAL & INTERNAL Pub Date : 2024-07-01 DOI: 10.1370/afm.3126
Sarah C Gebauer, Jacqueline K Kueper, Danielle Varda, Jennifer A Lawlor, John M Westfall, Judith Belle Brown

Purpose: This study marks the 50th anniversary of NAPCRG (formerly the North American Primary Care Research Group) by examining social connections among members.

Methods: This descriptive social network analysis was conducted via the Program to Analyze, Record, and Track Networks to Enhance Relationships (PARTNER) survey tool.

Results: Responses from 906 participants resulted in 1,721 individuals with 5,196 partner relationships. Most relationships (60%) were characterized as having an integrated level of collaboration. Many relationships led to a research paper (58%) or a grant (34%).

Conclusions: This social network analysis of NAPCRG members' relationships described over 5,000 relationships, many producing publications, grants, and perceived advancements in primary care.

目的:本研究通过考察成员之间的社会关系来纪念 NAPCRG(前身为北美初级保健研究小组)成立 50 周年:这项描述性社会网络分析是通过 "分析、记录和跟踪网络以加强关系计划"(PARTNER)调查工具进行的:906 名参与者的回复结果显示,1721 人拥有 5196 个伴侣关系。大多数关系(60%)被描述为具有综合合作水平。许多关系导致了一篇研究论文(58%)或一项基金(34%):对 NAPCRG 成员关系的社会网络分析描述了 5,000 多条关系,其中许多关系产生了论文、基金,并使人们认识到初级保健的进步。
{"title":"Fifty Years of Connection: Characterizing the Social Network of a Primary Care Research Organization.","authors":"Sarah C Gebauer, Jacqueline K Kueper, Danielle Varda, Jennifer A Lawlor, John M Westfall, Judith Belle Brown","doi":"10.1370/afm.3126","DOIUrl":"10.1370/afm.3126","url":null,"abstract":"<p><strong>Purpose: </strong>This study marks the 50th anniversary of NAPCRG (formerly the North American Primary Care Research Group) by examining social connections among members.</p><p><strong>Methods: </strong>This descriptive social network analysis was conducted via the Program to Analyze, Record, and Track Networks to Enhance Relationships (PARTNER) survey tool.</p><p><strong>Results: </strong>Responses from 906 participants resulted in 1,721 individuals with 5,196 partner relationships. Most relationships (60%) were characterized as having an integrated level of collaboration. Many relationships led to a research paper (58%) or a grant (34%).</p><p><strong>Conclusions: </strong>This social network analysis of NAPCRG members' relationships described over 5,000 relationships, many producing publications, grants, and perceived advancements in primary care.</p>","PeriodicalId":50973,"journal":{"name":"Annals of Family Medicine","volume":"22 4","pages":"333-335"},"PeriodicalIF":4.4,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11268698/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141749618","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Nirmatrelvir/Ritonavir Regimen for Mild/Moderately Severe COVID-19: A Rapid Review With Meta-Analysis and Trial Sequential Analysis. 用于轻度/中度严重 COVID-19 的 Nirmatrelvir/Ritonavir 方案:带有 Meta 分析和试验序列分析的快速回顾。
IF 4.4 2区 医学 Q1 MEDICINE, GENERAL & INTERNAL Pub Date : 2024-07-01 DOI: 10.1370/afm.3120
George N Okoli, Nicole Askin, Rasheda Rabbani

Background: The efficacy, effectiveness, and safety of the approved nirmatrelvir/ritonavir regimen for treatment of laboratory-confirmed mild/moderately severe COVID-19 remains unclear.

Methods: We systematically identified randomized controlled trials (RCTs) and real-world studies (RWS; observational studies) of the efficacy/effectiveness and/or safety of the approved nirmatrelvir/ritonavir regimen for COVID-19. We pooled appropriate data (adjusted estimates for RWS) using an inverse variance, random-effects model. We calculated statistical heterogeneity using the I 2 statistic. Results are presented as relative risk (RR) with associated 95% CI. We further assessed risk of bias/study quality and conducted trial sequential analysis of the evidence from RCTs.

Results: We included 4 RCTs (4,070 persons) and 16 RWS (1,925,047 persons) of adults (aged ≥18 years). One and 3 RCTs were of low and unclear risk of bias, respectively. The RWS were of good quality. Nirmatrelvir/ritonavir significantly decreased COVID-19 hospitalization compared with placebo/no treatment (RR = 0.17; 95% CI, 0.10-0.31; I 2 = 77.2%; 2 RCTs, 3,542 persons), but there was no significant difference for decrease of worsening severity (RR = 0.82; 95% CI, 0.66-1.01; I 2 = 47.5%; 3 RCTs, 1,824 persons), viral clearance (RR = 1.19; 95% CI, 0.93-1.51; I 2 = 82%; 2 RCTs, 528 persons), adverse events (RR = 1.41; 95% CI, 0.92-2.14; I 2 = 70.6%; 4 RCTs, 4,070 persons), serious adverse events (RR = 0.82; 95% CI, 0.41-1.62; I 2 = 0%; 3 RCTs, 3,806 persons), and all-cause mortality (RR = 0.27; 95% CI, 0.04-1.70; I 2 = 49.9%; 3 RCTs, 3,806 persons), although trial sequential analysis suggested that the current total sample sizes for these outcomes were not large enough for conclusions to be drawn. Real-world studies also showed significantly decreased COVID-19 hospitalization (RR = 0.48; 95% CI, 0.37-0.60; I 2 = 95.0%; 11 RWS, 1,421,398 persons) and all-cause mortality (RR = 0.24; 95% CI, 0.14-0.34; I 2 = 65%; 7 RWS, 286,131 persons) for nirmatrelvir/ritonavir compared with no treatment.

Conclusions: Nirmatrelvir/ritonavir appears to be promising for preventing hospitalization and potentially decreasing all-cause mortality for persons with mild/moderately severe COVID-19, but the evidence is weak. More studies are needed.

背景已获批准的尼尔马特韦/利托那韦方案治疗实验室确诊的轻度/中度重度 COVID-19 的疗效、有效性和安全性仍不明确:我们系统地确定了已获批准的奈瑞韦/利托那韦方案治疗 COVID-19 的疗效/有效性和/或安全性的随机对照试验 (RCT) 和真实世界研究 (RWS;观察性研究)。我们采用反方差随机效应模型汇集了适当的数据(RWS 的调整估计值)。我们使用 I 2 统计量计算统计异质性。结果以相对风险 (RR) 及相关的 95% CI 表示。我们进一步评估了偏倚风险/研究质量,并对来自 RCT 的证据进行了试验序列分析:我们纳入了针对成人(年龄≥18 岁)的 4 项 RCT(4,070 人)和 16 项 RWS(1,925,047 人)。分别有 1 项和 3 项研究性试验存在低偏倚风险和不明确偏倚风险。RWS质量良好。与安慰剂/不治疗相比,Nirmatrelvir/利托那韦能显著降低COVID-19的住院率(RR = 0.17; 95% CI, 0.10-0.31; I 2 = 77.2%; 2项研究,3,542人),但在降低恶化严重程度方面没有显著差异(RR = 0.82;95% CI,0.66-1.01;I 2 = 47.5%;3 项 RCT,1 824 人)、病毒清除率(RR = 1.19;95% CI,0.93-1.51;I 2 = 82%;2 项 RCT,528 人)、不良事件(RR = 1.41;95% CI,0.92-2.14;I 2 = 70.6%;4 项 RCT,4070 人)、严重不良事件(RR = 0.82;95% CI,0.41-1.62;I 2 = 0%;3 项 RCT,3806 人)和全因死亡率(RR = 0.27;95% CI,0.04-1.70;I 2 = 49.9%;3 项 RCT,3806 人),但试验顺序分析表明,目前这些结果的总样本量还不足以得出结论。真实世界研究还显示,与不治疗相比,尼马瑞韦/利托那韦的COVID-19住院率(RR=0.48;95% CI,0.37-0.60;I 2=95.0%;11个RWS,1,421,398人)和全因死亡率(RR=0.24;95% CI,0.14-0.34;I 2=65%;7个RWS,286,131人)显著降低:结论:对于轻度/中度重度 COVID-19 患者,尼马瑞韦/利托那韦似乎有望预防住院并降低全因死亡率,但证据尚不充分。还需要更多的研究。
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引用次数: 0
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Annals of Family Medicine
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