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The Importance of Investigating Sex-Related Disparities in Valvular Heart Disease 研究瓣膜性心脏病性别差异的重要性
IF 3.9 2区 医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2026-03-01 Epub Date: 2025-08-22 DOI: 10.1016/j.athoracsur.2025.07.048
Rashmi Nedadur MD, MSc, Mohsyn Imran Malik MD, MSc, Michael W.A. Chu MD, MEd
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引用次数: 0
Longitudinal Data Sets in Cardiac Surgery 心脏外科的纵向数据集。
IF 3.9 2区 医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2026-03-01 Epub Date: 2025-11-21 DOI: 10.1016/j.athoracsur.2025.11.013
J. Hunter Mehaffey MD, MSc , Justin Schaffer MD , Robert B. Hawkins MD, MSc , Makoto Mori MD, PhD , Raymond Strobel MD, MSc , Irbaz Hameed MD, PhD , Ram Subramanyan MD, PhD , Michael Bowdish MD , Vinay Badhwar MD
There is a growing recognition of the importance of longitudinal outcomes after cardiac surgery defining durability of interventions, with an increasing number of publications using a variety of data sources. The purpose of this review is to provide a clinically relevant summary of commonly used longitudinal data sources in cardiac surgery to facilitate broader research use. A group of clinical cardiac surgeons with content expertise in longitudinal data identified the commonly used and high-quality data sources. An overview is provided for each data source as as specific strengths and limitations unique to the clinical interpretation of studies from each data set.
随着越来越多的出版物使用各种数据来源,人们越来越认识到心脏手术后纵向结果定义干预措施持久性的重要性。本文的目的是为心脏外科常用的纵向数据来源提供临床相关的总结,以促进更广泛的研究使用。一组具有纵向数据内容专业知识的临床心脏外科医生确定了常用和高质量的数据源。概述了每个数据源,以及每个数据集研究的临床解释的独特优势和局限性。
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引用次数: 0
From Pickup to Patient: How Far Should a Heart Travel? 从卡车到病人:心脏应该走多远?
IF 3.9 2区 医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2026-03-01 Epub Date: 2025-10-24 DOI: 10.1016/j.athoracsur.2025.09.041
Antonia Kreso MD
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引用次数: 0
Society Board 社会委员会
IF 3.9 2区 医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2026-03-01 Epub Date: 2026-02-20 DOI: 10.1016/S0003-4975(26)00030-5
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引用次数: 0
Methodologic Considerations in Sex-Based Outcomes After Mitral Valve Repair 二尖瓣修复后基于性别结果的方法学考虑。
IF 3.9 2区 医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2026-03-01 Epub Date: 2025-07-10 DOI: 10.1016/j.athoracsur.2025.06.034
Aabir Imran MBBS, Aaila Haider MBBS
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引用次数: 0
When Minimally Invasive Meets Minimally Anesthetized: Is Less Really More? 当微创与微创麻醉:少真的多吗?
IF 3.9 2区 医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2026-03-01 Epub Date: 2026-01-07 DOI: 10.1016/j.athoracsur.2025.12.026
Elliot L. Servais MD
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引用次数: 0
Surgical Approaches in Congenital Heart Disease With Congenital Diaphragmatic Hernia: A Multiinstitutional Analysis 先天性心脏病合并先天性膈疝的手术入路:一项多机构分析。
IF 3.9 2区 医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2026-03-01 Epub Date: 2025-08-21 DOI: 10.1016/j.athoracsur.2025.07.043
Kylie I. Holden MD, MS , Ashley H. Ebanks NP , Amir M. Khan MD , Anthony Johnson DO , Michael McMullan MD , Charles S. Cox Jr. MD , Matthew T. Harting MD, MS , Damien J. LaPar MD, MSc , CDH Study Group

Background

Surgical decision making for congenital heart disease (CHD) with concomitant congenital diaphragmatic hernia (CDH) remains a notable challenge. This study analyzed the relationship between surgical timing and outcomes for patients with both CDH and CHD (CDH + CHD).

Methods

A retrospective analysis of patients with CDH + CHD was performed using data from the multiinstitutional CDH Study Group registry (2007-2022). CDH was categorized by defect size (A-D, smallest to largest) and cardiac anomalies stratified by Society of Thoracic Surgeons-European Association for Cardio-Thoracic Surgery (STAT) category. Multivariable regression models and Loess smoothing analyses were used, focusing on patient mortality as a function of defect size and surgery timing.

Results

Among 9261 patients with CDH, 1886 had CDH + CHD, and 209 (11.1%) underwent both cardiac and diaphragm repair. A total of 94.3% (n = 197) underwent diaphragmatic repair before the cardiac operation, and STAT category distribution was as follows: 1, 30.1%; 2, 27.3%; 3, 15.8%; 4, 20.1%; and 5, 6.7%. Overall mortality was 23.4%. Multilevel mix-effects logistic regression identified extracorporeal life support as a significant predictor of in-hospital mortality (odds ratio, 5.74; P = .001). When stratified by STAT category, patient mortality correlated with CDH Study Group stage. Median time between operations was 46 days (survivors, 51; nonsurvivors, 39; P = .20) and varied by STAT category. Survival after cardiac operations was greatest 30 to 80 days after CDH repair.

Conclusions

CHD operation outcomes are influenced by CDH size or severity and STAT category risk. CDH repair is almost universally completed before a CHD operation, with the most selected timing for CHD operations occurring 30 to 80 days after CDH repair. These data provide insight into current practice and evidence to guide surgical decision making strategies for patients with CDH + CHD.
背景:先天性心脏病(CHD)合并先天性膈疝(CDH)的手术决策仍然是一个值得注意的挑战。本研究分析了CDH+冠心病手术时机与预后的关系。方法:采用多机构CDH研究组注册表(2007-2022)的数据,对CDH+冠心病患者进行回顾性分析。CDH按缺陷大小(A-D,最小-最大)分类,心脏异常按STAT分类分层。采用多变量回归模型和黄土平滑分析,关注患者死亡率作为缺陷大小和手术时间的函数。结果:在9261例CDH患者中,1886例合并CDH+冠心病,209例(11.1%)同时行心脏和隔膜修复术。94.3% (n=197)的患者在心脏手术前进行了膈修复,STAT分类分布为STAT1(30.1%)、2(27.3%)、3(15.8%)、4(20.1%)和5(6.7%)。总死亡率为23.4%。多水平混合效应logistic回归发现体外生命支持是院内死亡率的重要预测因子(OR=5.74, p=0.001)。当按STAT分类分层时,患者死亡率与CDHSG分期相关。手术间隔的中位时间为46天(幸存者51天,非幸存者39天,p=0.20),因STAT分类而异。心脏手术后CDH修复后30-80天生存率最高。结论:冠心病手术结果受冠心病大小/严重程度和STAT分类风险的影响。CDH修复几乎普遍在冠心病手术前完成,大多数选择在CDH修复后30-80天进行冠心病手术。这些数据为指导CDH+冠心病患者的手术决策策略提供了当前的实践和证据。
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引用次数: 0
Impact of Transcatheter Aortic Valve Replacement Volume on Outcomes in Patients With End-Stage Renal Disease 经导管主动脉瓣置换量对终末期肾病患者预后的影响
IF 3.9 2区 医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2026-03-01 Epub Date: 2025-08-27 DOI: 10.1016/j.athoracsur.2025.08.009
Esteban Aguayo MD , Oh Jin Kwon MD , Mitchell Won MD , Saad Mallick MD , Troy Coaston BS , Amulya Vadlakonda BS , Kevin Tabibian BS , Yas Sanaiha MD , Richard J. Shemin MD , Peyman Benharash MD

Background

Patients with end-stage renal disease (ESRD) are at increased risk for calcific aortic stenosis. Given limited data on the efficacy of transcatheter aortic valve replacement (TAVR) in this population, the present study examined acute mortality, complications, and 30-day nonelective readmissions in a national cohort of patients with ESRD.

Methods

The 2016 to 2021 National Readmissions Database was queried to identify all TAVR admissions (in patients aged ≥18 years). Patients were stratified into ESRD and non-ESRD cohorts. Primary outcomes included in-hospital mortality and 30-day readmissions, whereas perioperative complications, length of stay, and hospitalization costs were secondarily assessed. Multivariable logistic regression and Nelson-Aalen cumulative hazard analysis were used to evaluate factors associated with mortality and readmissions, stratified by institutional TAVR volume. Low-volume and high-volume hospitals were defined by quartiles of annual procedural volume.

Results

Among 411,311 patients undergoing TAVR, 7.3% had ESRD. After risk adjustment, ESRD remained associated with higher mortality (adjusted odds ratio, 1.79; 95% CI, 1.59-2.00) and readmissions (adjusted odds ratio, 1.87; 95% CI, 1.78-1.96). Additionally, ESRD was linked to increased length of stay (β, +1.3 days; 95% CI, 1.1-1.5) and costs (β, +$1.0K; 95% CI, 0.5K-1.5K). After accounting for TAVR volume, non-ESRD was associated with a lower risk of mortality and readmission at high-volume hospitals compared with low-volume hospitals, whereas ESRD was associated with similar risks regardless of institutional volume.

Conclusions

Patients with ESRD are at increased risk for postoperative mortality, hospital resource use, and readmissions. This association was not mitigated at high–TAVR volume centers. Given the increased risk of mortality and readmission, careful patient selection and optimization are crucial for patients with ESRD who are undergoing TAVR.
背景:终末期肾病(ESRD)患者发生钙化性主动脉狭窄的风险增加。考虑到经导管主动脉瓣置换术(TAVR)在该人群中的有效性数据有限,本研究在全国ESRD患者队列中检查了急性死亡率、并发症和30天非选择性再入院。方法:查询2016-2021年国家再入院数据库,以确定所有TAVR入院(≥18年)。患者被分为ESRD组和非ESRD组。主要结局包括住院死亡率和30天再入院,其次评估围手术期并发症、住院时间(LOS)和住院费用。采用多变量logistic回归和Nelson-Aalen累积风险分析来评估与死亡率和再入院相关的因素,并按机构TAVR量分层。低容量医院(LVH)和高容量医院(HVH)以年手术量的四分位数来定义。结果:在411,311例接受TAVR的患者中,7.3%发生了ESRD。风险调整后,ESRD仍与较高的死亡率(AOR 1.79, 95%CI 1.59-2.00)和再入院率(AOR 1.87, 95%CI 1.78-1.96)相关。此外,ESRD与LOS增加(β+1.3天,95%CI 1.1-1.5)和成本(β+$1.0K, 95%CI 0.5K-1.5K)有关。在考虑TAVR容量后,与LVH相比,非ESRD与HVH的死亡率和再入院风险较低,而ESRD与类似的风险相关,无论机构容量如何。结论:ESRD患者术后死亡率、医院资源利用率和再入院风险增加。这种关联在高TAVR容积中心没有减轻。考虑到死亡和再入院的风险增加,对于接受TAVR的ESRD患者,谨慎的患者选择和优化是至关重要的。
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引用次数: 0
Randomized Trial of High-Flow Nasal Cannula vs Double-Lumen Endotracheal Tube or Laryngeal Mask for Thoracoscopic Surgery 大流量鼻插管与双腔气管内管或喉罩用于胸腔镜手术的随机试验。
IF 3.9 2区 医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2026-03-01 Epub Date: 2025-11-25 DOI: 10.1016/j.athoracsur.2025.11.020
Bu Long MD , Yahong Liu BS , Furong Lin MD , Yaoliang Zhang MD , Guilin Peng PhD , Chao Yang PhD , Sida Liao MD , Lan Lan PhD

Background

High-flow nasal cannula (HFNC) oxygen therapy is widely used primarily for preoxygenation and postextubation respiratory support. However, its intraoperative application remains uncommon. This study evaluated the effects of the HFNC on respiratory mechanics and hemodynamics in thoracoscopic surgery under spontaneous ventilation.

Methods

This randomized trial included 165 patients scheduled for thoracoscopic surgery from 2023 to 2024. Patients were assigned to 3 ventilation supports: double-lumen endotracheal tube (intubation group, n = 55), laryngeal mask airway group (n = 55), or HFNC (n = 55). Intraoperative respiratory and hemodynamic changes, postoperative recovery, and adverse effects were analyzed.

Results

The oxygenation index was comparable intraoperatively but higher in the HFNC group 5 minutes after extubation (P = .018). Intraoperative carbon dioxide was higher in the HFNC and laryngeal mask airway groups (P < .05) but gradually normalized postoperatively. The HFNC shortened extubation time (30 vs 33 vs 37 minutes; P = .005) and postoperative anesthesia care unit stay (70 vs 75 vs 85 minutes; P < .001) and reduced the incidence of nausea, sore throat, and dizziness in the 24 hours postoperatively (P = .005, P = .001, P = .002). HFNC patients demonstrated improved early mobility and nocturnal sleep and lower numeric pain rating scale score at rest and during activity (P < .05). Propofol and opioid use was lower in the HFNC group (P = .016, P < .001), whereas dexmedetomidine consumption was higher (P = .002).

Conclusions

The HFNC provides a stable form of anesthesia compared with laryngeal mask and intubation and is associated with early improved rehabilitation in thoracoscopic surgery.
背景:高流量鼻插管(HFNC)氧疗主要用于预充氧和拔管后呼吸支持。然而,术中应用仍不常见。本研究评估HFNC对自主通气胸腔镜手术中呼吸力学和血流动力学的影响。方法:本随机试验纳入165例计划于2023年至2024年进行胸腔镜手术的患者。患者被分配到三种通气支持:双腔气管内管(插管组,n=55),喉罩气道(LMA组,n=55)或HFNC (n=55)。分析术中呼吸和血流动力学变化、术后恢复情况及不良反应。结果:术中氧合指数比较,拔管后5 min HFNC组氧合指数较高(P = 0.018)。HFNC组和LMA组术中二氧化碳含量较高(P < 0.05),但术后逐渐恢复正常。HFNC缩短了拔管时间(30 min vs 33 min vs 37 min, P = 0.005)和术后麻醉护理单位停留时间(70 min vs 75 min vs 85 min, P < 0.001),降低了术后24小时恶心、咽痛、头晕的发生率(P = 0.005, P = 0.001, P = 0.002)。HFNC患者表现出早期活动能力和夜间睡眠改善,休息和活动时数值疼痛评定量表得分较低(P < 0.05)。HFNC组丙泊酚和阿片类药物用量较低(P = 0.016, P < 0.001),右美托咪定用量较高(P = 0.002)。结论:与喉罩和插管相比,HFNC提供了一种稳定的麻醉形式,并与胸腔镜手术早期康复改善有关。
{"title":"Randomized Trial of High-Flow Nasal Cannula vs Double-Lumen Endotracheal Tube or Laryngeal Mask for Thoracoscopic Surgery","authors":"Bu Long MD ,&nbsp;Yahong Liu BS ,&nbsp;Furong Lin MD ,&nbsp;Yaoliang Zhang MD ,&nbsp;Guilin Peng PhD ,&nbsp;Chao Yang PhD ,&nbsp;Sida Liao MD ,&nbsp;Lan Lan PhD","doi":"10.1016/j.athoracsur.2025.11.020","DOIUrl":"10.1016/j.athoracsur.2025.11.020","url":null,"abstract":"<div><h3>Background</h3><div>High-flow nasal cannula (HFNC) oxygen therapy is widely used primarily for preoxygenation and postextubation respiratory support. However, its intraoperative application remains uncommon. This study evaluated the effects of the HFNC on respiratory mechanics and hemodynamics in thoracoscopic surgery under spontaneous ventilation.</div></div><div><h3>Methods</h3><div>This randomized trial included 165 patients scheduled for thoracoscopic surgery from 2023 to 2024. Patients were assigned to 3 ventilation supports: double-lumen endotracheal tube (intubation group, n = 55), laryngeal mask airway group (n = 55), or HFNC (n = 55). Intraoperative respiratory and hemodynamic changes, postoperative recovery, and adverse effects were analyzed.</div></div><div><h3>Results</h3><div>The oxygenation index was comparable intraoperatively but higher in the HFNC group 5 minutes after extubation (<em>P</em> = .018). Intraoperative carbon dioxide was higher in the HFNC and laryngeal mask airway groups (<em>P</em> &lt; .05) but gradually normalized postoperatively. The HFNC shortened extubation time (30 vs 33 vs 37 minutes; <em>P</em> = .005) and postoperative anesthesia care unit stay (70 vs 75 vs 85 minutes; <em>P</em> &lt; .001) and reduced the incidence of nausea, sore throat, and dizziness in the 24 hours postoperatively (<em>P</em> = .005, <em>P</em> = .001, <em>P</em> = .002). HFNC patients demonstrated improved early mobility and nocturnal sleep and lower numeric pain rating scale score at rest and during activity (<em>P</em> &lt; .05). Propofol and opioid use was lower in the HFNC group (<em>P</em> = .016, <em>P</em> &lt; .001), whereas dexmedetomidine consumption was higher (<em>P</em> = .002).</div></div><div><h3>Conclusions</h3><div>The HFNC provides a stable form of anesthesia compared with laryngeal mask and intubation and is associated with early improved rehabilitation in thoracoscopic surgery.</div></div>","PeriodicalId":50976,"journal":{"name":"Annals of Thoracic Surgery","volume":"121 3","pages":"Pages 705-714"},"PeriodicalIF":3.9,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145642368","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Society of Thoracic Surgeons General Thoracic Surgery Database: 2025 Annual Update 美国胸外科学会普通胸外科数据库:2025年年度更新。
IF 3.9 2区 医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2026-03-01 Epub Date: 2025-12-15 DOI: 10.1016/j.athoracsur.2025.11.028
Gillian C. Alex MD , Kathryn Engelhardt MD, MS , Ravi Rajaram MD, MSC , William Burfeind MD , Leigh Ann Jones BS , Zouheri ElHalabi BS, BE , Robert Habib PhD , Christopher W. Seder MD , Elizabeth David MD
The Society of Thoracic Surgeons General Thoracic Surgery Database (GTSD) is the largest and most comprehensive clinical registry for thoracic surgical procedures worldwide. Designed to provide risk-adjusted benchmarking, support quality improvement, and advance research, the GTSD now houses >800,000 records from >300 participating sites. The 2025 annual update highlights several key developments. A major revision of the data collection form reduced abstraction burden while introducing new variables to support long-term outcome modeling. Web-based risk calculators for pulmonary resection and esophagectomy were launched in 2024, and long-term risk models were introduced in 2025. Procedural trends reflect the continued rise of minimally invasive and robotic-assisted techniques, accompanied by improved outcomes across morbidity and mortality measures. The star rating system has been retired in favor of more nuanced risk-adjusted metrics. The Access and Publications program, Participant User File program, and Task Force on Funded Research continue to ensure data reliability and facilitate broad scientific output. Collectively, these initiatives reinforce the GTSD’s role as both a cornerstone of quality improvement and a driver of new knowledge in thoracic surgery, advancing surgical excellence and patient outcomes.
美国胸外科学会普通胸外科数据库(GTSD)是世界上最大、最全面的胸外科手术临床注册库。旨在提供风险调整基准,支持质量改进和推进研究,政府资讯科技署目前收集了来自300多个参与网站的80多万份记录。2025年年度更新报告强调了几个关键发展。数据收集表单的主要修订减少了抽象负担,同时引入了支持长期结果建模的新变量。基于网络的肺切除术和食管切除术风险计算器于2024年推出,长期风险模型于2025年推出。手术趋势反映了微创和机器人辅助技术的持续增长,伴随着发病率和死亡率指标的改善。星级评级系统已经被淘汰,取而代之的是更细致入微的风险调整指标,这反映了对需求出版物(A&P)计划、参与者用户文件(PUF)计划和资助研究工作组的不断发展的承诺——继续确保数据可靠性和促进广泛的科学产出。总的来说,这些举措加强了GTSD作为质量改进的基石和胸外科新知识的驱动者的作用,提高了手术的质量和患者的治疗效果。
{"title":"The Society of Thoracic Surgeons General Thoracic Surgery Database: 2025 Annual Update","authors":"Gillian C. Alex MD ,&nbsp;Kathryn Engelhardt MD, MS ,&nbsp;Ravi Rajaram MD, MSC ,&nbsp;William Burfeind MD ,&nbsp;Leigh Ann Jones BS ,&nbsp;Zouheri ElHalabi BS, BE ,&nbsp;Robert Habib PhD ,&nbsp;Christopher W. Seder MD ,&nbsp;Elizabeth David MD","doi":"10.1016/j.athoracsur.2025.11.028","DOIUrl":"10.1016/j.athoracsur.2025.11.028","url":null,"abstract":"<div><div>The Society of Thoracic Surgeons General Thoracic Surgery Database (GTSD) is the largest and most comprehensive clinical registry for thoracic surgical procedures worldwide. Designed to provide risk-adjusted benchmarking, support quality improvement, and advance research, the GTSD now houses &gt;800,000 records from &gt;300 participating sites. The 2025 annual update highlights several key developments. A major revision of the data collection form reduced abstraction burden while introducing new variables to support long-term outcome modeling. Web-based risk calculators for pulmonary resection and esophagectomy were launched in 2024, and long-term risk models were introduced in 2025. Procedural trends reflect the continued rise of minimally invasive and robotic-assisted techniques, accompanied by improved outcomes across morbidity and mortality measures. The star rating system has been retired in favor of more nuanced risk-adjusted metrics. The Access and Publications program, Participant User File program, and Task Force on Funded Research continue to ensure data reliability and facilitate broad scientific output. Collectively, these initiatives reinforce the GTSD’s role as both a cornerstone of quality improvement and a driver of new knowledge in thoracic surgery, advancing surgical excellence and patient outcomes.</div></div>","PeriodicalId":50976,"journal":{"name":"Annals of Thoracic Surgery","volume":"121 3","pages":"Pages 521-531"},"PeriodicalIF":3.9,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145776286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
Annals of Thoracic Surgery
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