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The relationship between results of coronary angiography, Mediterranean-type lifestyle, type D personality, and healthy life expectancy. 冠状动脉造影结果、地中海型生活方式、D型人格与健康预期寿命的关系
IF 0.5 4区 医学 Q4 SURGERY Pub Date : 2023-01-01 DOI: 10.24875/CIRU.22000443
Füsun Afşar, Ahmet Güler, Habip Yılmaz

Aim: The aim of this study was to determine the relationship between coronary angiography results and Mediterranean-type lifestyle and type D personality.

Methods: Mediterranean-type lifestyle index and type D personality scale were administered to 230 participants.

Results: In univariate analysis according to coronary angiography results, a statistically significant effect was determined between the decision for treatment with percutaneous coronary intervention (PCI) and diabetes mellitus, and total and subscale points of Mediterranean lifestyle index, and between the decision for treatment with bypass and body mass index, Mediterranean diet, physical activity, and total points. In multivariate analysis, there was determined to be an effect between the PCI and systolic pressure, and between bypass and body mass index and subscale of physical activity. When disease-free life expectancy was examined, there was seen to be a negative effect of smoking and low Mediterranean diet points for participants with PCI, and of smoking, presence of hypertension, family history, and high type D personal characteristics score for those with bypass decision.

Conclusion: The evidence-based recommendations for a Mediterranean-type lifestyle stated in cardiovascular disease (CVD) preventative guidelines may have a positive effect on the prevention of CVD, disability-free life, and mortality.

目的:本研究的目的是确定冠状动脉造影结果与地中海型生活方式和D型人格之间的关系。方法:采用地中海式生活方式指数和D型人格量表对230名受试者进行调查。结果:根据冠状动脉造影结果进行单因素分析,经皮冠状动脉介入治疗(PCI)和糖尿病的决定与地中海生活方式指数总分和亚量表分之间,以及旁路治疗的决定与体重指数、地中海饮食、体力活动和总分之间的影响具有统计学意义。在多变量分析中,PCI与收缩压之间、旁路与体重指数和身体活动亚量表之间存在影响。当检查无病预期寿命时,发现吸烟和低地中海饮食对PCI患者有负面影响,而吸烟、存在高血压、家族史和高D型个人特征评分对搭桥患者有负面影响。结论:心血管疾病(CVD)预防指南中对地中海型生活方式的循证推荐可能对预防CVD、无残疾生活和死亡率有积极作用。
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引用次数: 0
Distribution of human papillomavirus prevalence, genotype, and PAP test results in women in the southeast of Turkey. 土耳其东南部妇女中人乳头瘤病毒流行率、基因型和PAP检测结果的分布
IF 0.5 4区 医学 Q4 SURGERY Pub Date : 2023-01-01 DOI: 10.24875/CIRU.22000400
Gulay Aydogdu

Background: The aim of this study was to investigate the prevalence, genotype, and distribution of cervical human papillomavirus (HPV) in women living in southeast Turkey.

Materials and methods: A total of 13,300 cervical smear materials were scanned and 899 cases found to be HPV-positive were included in the study. Cases were divided into seven groups according to age (under 19 years of age, 20-24, 25-29, 30-39, 40-49, 50-59, and over 60 years old) and six groups according to HPV types (HPV type 16, HPV type 18, HPV type 16-18 association, HPV type 16-high risk (HR) association, HPV Type 18-HR association, and HPV HR [31,33,35,39,45, 51,52,56,58,59,66, and 68]). SurePath liquid-based cytology preparations were evaluated, and HPV tests were performed using real-time-polymerase chain reaction.

Results: A total of 6.7% of cervical smear samples were positive for HPV DNA. The mean age of these cases was 41 years (range 15-78 years). All HPV types showed the highest rate of positivity in the 30-39 age groups. Regarding the distribution of HPV types, most of the cases were in the HPV HR group (66%). The most common atypia category detected in cytological examination was "Atypical squamous cells of undetermined significance" (ASC-US) (27%).

Conclusions: It was determined that the prevalence of HPV in the southeast of Turkey is lower than the world average, the most common HPV type in our region is HPV-HR, and HPV peaks at older ages compared to what has been reported for other regions of the world.

背景:本研究的目的是调查土耳其东南部妇女宫颈人乳头瘤病毒(HPV)的患病率、基因型和分布。材料与方法:共扫描13300份宫颈涂片材料,其中899例hpv阳性纳入研究。病例按年龄分为7组(19岁以下、20-24岁、25-29岁、30-39岁、40-49岁、50-59岁、60岁以上),按HPV类型分为6组(HPV 16型、HPV 18型、HPV 16-18型关联、HPV 16型高危(HR)关联、HPV 18-HR关联、HPV HR[31、33、35、39、45、51、52、56、58、59、66、68])。评估SurePath液体细胞学制剂,并使用实时聚合酶链反应进行HPV检测。结果:6.7%的宫颈涂片样本HPV DNA阳性。这些病例的平均年龄为41岁(15-78岁)。所有HPV类型在30-39岁年龄组的阳性率最高。在HPV型别分布方面,大多数病例为HPV HR组(66%)。细胞学检查中最常见的非典型类型是“不确定意义的非典型鳞状细胞”(ASC-US)(27%)。结论:确定土耳其东南部的HPV患病率低于世界平均水平,我们地区最常见的HPV类型是HPV- hr,与世界其他地区报道的相比,HPV的高峰年龄较大。
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引用次数: 0
Predictivity of aspartate aminotransferase to alanine aminotransferase (De Ritis) ratio for detecting bowel necrosis in incarcerated inguinal hernia patients. 谷草转氨酶与丙氨酸转氨酶(De Ritis)比值对嵌套腹股沟疝患者肠坏死的预测价值。
IF 0.5 4区 医学 Q4 SURGERY Pub Date : 2023-01-01 DOI: 10.24875/CIRU.22000273
Umit Turan, Ahmet Baris-Dirim

Purpose: Early diagnosis of necrotic bowel segment resulting from incarcerated inguinal hernia (IIH) is crucial for reducing morbidity and mortality. The aim of this study was to investigate the efficacy of the De Ritis ratio (DRR), also known as the ratio of aspartate aminotransferase to alanine aminotransferase, as a biomarker for intestinal necrosis.

Methods: This retrospective study included 132 patients who underwent emergency surgery for IIH. Patients were divided into two groups: those who underwent bowel resection for necrosis (Group 1) and those who did not (Group 2). Patients' demographic and clinical data were recorded. Using laboratory test results, DRR, neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), lymphocyte-to-monocyte ratio (LMR), and lymphocyte-to-CRP ratio (LCR) were calculated.

Results: The morbidity and mortality rates and the length of stay for Group 1 were statistically significantly different (p < 0.0001). The DRR, NLR, PLR, LMR, and LCR values of the same group were also significantly different (p < 0.05).

Conclusion: DRR can be used as a biomarker for early diagnosis of bowel necrosis in patients with IIH.

目的:嵌顿性腹股沟疝(IIH)致肠段坏死的早期诊断对降低发病率和死亡率至关重要。本研究的目的是研究德炎比(DRR),也称为天冬氨酸转氨酶与丙氨酸转氨酶的比值,作为肠坏死的生物标志物的有效性。方法:本回顾性研究纳入132例因IIH接受急诊手术的患者。患者分为两组:接受肠坏死切除术的患者(1组)和未接受肠坏死切除术的患者(2组)。记录患者的人口统计学和临床资料。根据实验室检测结果,计算DRR、中性粒细胞与淋巴细胞比值(NLR)、血小板与淋巴细胞比值(PLR)、淋巴细胞与单核细胞比值(LMR)和淋巴细胞与crp比值(LCR)。结果:两组患者的发病率、死亡率及住院时间比较,差异有统计学意义(p < 0.0001)。同一组的DRR、NLR、PLR、LMR、LCR值差异均有统计学意义(p < 0.05)。结论:DRR可作为IIH患者肠坏死早期诊断的生物标志物。
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引用次数: 0
Do prolonged syndrome of COVID-19 and variants of SARS-COV-2 cause hepatitis of unknown origin in Oaxaca? 在瓦哈卡州,COVID-19的延长综合征和SARS-COV-2的变体会引起不明原因的肝炎吗?
IF 0.5 4区 医学 Q4 SURGERY Pub Date : 2023-01-01 DOI: 10.24875/CIRU.22000323
Sergio A Ramírez-García
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引用次数: 0
Anesthetic management of a child with Loeys-Dietz syndrome undergoing complete aortic arch replacement. Loeys-Dietz综合征患儿完全性主动脉弓置换术的麻醉处理。
IF 0.5 4区 医学 Q4 SURGERY Pub Date : 2023-01-01 DOI: 10.24875/CIRU.21000786
Unai Olabarrieta-Zarain, Leire Martínez-Santos, Alex Alberdi-Enríquez, Ane Guereca-Gala, Blanca Bravo-Sevilla, Alberto Martínez-Ruiz

Loeys-Dietz syndrome (LDS) is a connective tissue disease related to β-transforming growth factor mutations, which causes aneurysms formation, vascular tortuosity and skeletal manifestations. The prognosis is very poor, and mortality occurs at the age of 27 in patients without surgical treatment. Despite being diagnosed in childhood, is not usual surgical aortic replacement in children. We report a case of 12 years old child with LDS and multiple aneurysms in thoracic aorta, undergoing complete aortic arch replacement and our proposal for the anesthetic management, due to surgical complexity and implications in pediatric population.

Loeys-Dietz综合征(LDS)是一种与β转化生长因子突变相关的结缔组织疾病,可导致动脉瘤形成、血管扭曲和骨骼表现。预后很差,不进行手术治疗的患者在27岁时死亡。尽管在儿童时期被诊断出来,但在儿童中并不常见手术主动脉置换术。我们报告一例患有LDS和胸主动脉多发动脉瘤的12岁儿童,由于手术复杂性和对儿科人群的影响,我们建议进行完全主动脉弓置换术和麻醉处理。
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引用次数: 0
Peritoneal sarcoidosis that simulates peritoneal carcinomatosis: a case report. 模拟腹膜癌的腹膜结节病:1例报告。
IF 0.5 4区 医学 Q4 SURGERY Pub Date : 2023-01-01 DOI: 10.24875/CIRU.21000715
Julieta Zanatta-Scattolini, Cecilia I Rodríguez-Oses, José G Yaryura-Montero, Juan A Albiero, Jorge O Flores, Carlos I Ferrero

Sarcoidosis is a multisystem inflammatory disorder of unknown cause characterized by the formation of pleomorphic, non-caseating granulomas with predominantly pulmonary involvement. Although abdominal sarcoidosis represents 30% of extrapulmonary manifestations, peritoneal involvement is extremely rare. We will describe a rare case of peritoneal sarcoidosis simulating carcinomatosis in a young patient with abdominal pain who underwent laparoscopic examination.

结节病是一种病因不明的多系统炎性疾病,以多形性非干酪化肉芽肿为主,主要累及肺部为特征。虽然腹部结节病占肺外表现的30%,但累及腹膜极为罕见。我们将描述一个罕见的病例腹膜结节病模拟癌在一个年轻的病人腹痛谁接受腹腔镜检查。
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引用次数: 0
Hallazgos nasosinusales por tomografía computada en dacriocistitis crónica pediátrica. 小儿慢性泪囊炎的计算机断层扫描异常鼻征。
IF 0.5 4区 医学 Q4 SURGERY Pub Date : 2023-01-01 DOI: 10.24875/CIRU.20001361
Luz A Campos-Navarro, Margarita E Ibarra-Macari, Arcelia C Barrón-Campos, Juan M Moreno-Martínez, José A Almeyda-Farfán

Objective: To evaluate the preoperative tomographic characteristics of the nose and paranasal sinuses of children with chronic dacryocystitis.

Method: Prospective, observational, cross-sectional, and descriptive study. CT scans of the paranasal sinuses of patients candidates for endoscopic dacryocystorhinostomy were evaluated for two years. Demographic characteristics, radiological findings, inflammatory processes and anatomical variants were identified using the Lund-Mackay classification. Statistic analysis. Stata 10.0, descriptive analysis, Student's t: mean difference and χ2. Logistic studies to estimate the probability between variables.

Results: 27 men and 11 women (n = 38) were included. Of these, 22 had unilateral and 16 bilateral nasolacrimal duct involvement. Lund-Mackay score range: 2-20. Eleven patients had associated pathology. The most affected were anterior and maxillary ethmoidal sinus (69%), osteomeatal complex (68%), posterior ethmoidal (51%). Patients with severe rhinosinusitis are 12 times more likely to develop dacryocystitis than patients with < 12 points. Men presented greater severity, affectation, and clinical repercussion.

Conclusions: There is radiological rhinosinusal involvement in dacryocystitis, which must be evaluated and treated preoperatively to avoid postoperative complications or reinfections.

目的:探讨慢性泪囊炎患儿鼻及鼻窦的术前体层图特征。方法:前瞻性、观察性、横断面和描述性研究。对内镜下泪囊鼻腔造口术患者的鼻窦CT扫描进行了两年的评估。使用Lund-Mackay分类确定人口统计学特征、放射学表现、炎症过程和解剖变异。统计分析。Stata 10.0,描述性分析,Student’s t: mean difference和χ2。逻辑研究估计变量之间的概率。结果:纳入男性27例,女性11例(n = 38)。其中22例单侧鼻泪管受累,16例双侧鼻泪管受累。伦德-麦凯得分范围:2-20。11例患者有相关病理。受影响最大的是前、上颌筛窦(69%)、骨鼻道复合体(68%)、后筛窦(51%)。重度鼻窦炎患者发生泪囊炎的可能性是< 12分患者的12倍。男性表现出更严重、更做作和临床反应。结论:泪囊炎有鼻窦受累性,术前应及时评估和治疗,避免术后并发症和再感染。
{"title":"Hallazgos nasosinusales por tomografía computada en dacriocistitis crónica pediátrica.","authors":"Luz A Campos-Navarro,&nbsp;Margarita E Ibarra-Macari,&nbsp;Arcelia C Barrón-Campos,&nbsp;Juan M Moreno-Martínez,&nbsp;José A Almeyda-Farfán","doi":"10.24875/CIRU.20001361","DOIUrl":"https://doi.org/10.24875/CIRU.20001361","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the preoperative tomographic characteristics of the nose and paranasal sinuses of children with chronic dacryocystitis.</p><p><strong>Method: </strong>Prospective, observational, cross-sectional, and descriptive study. CT scans of the paranasal sinuses of patients candidates for endoscopic dacryocystorhinostomy were evaluated for two years. Demographic characteristics, radiological findings, inflammatory processes and anatomical variants were identified using the Lund-Mackay classification. Statistic analysis. Stata 10.0, descriptive analysis, Student's t: mean difference and χ<sup>2</sup>. Logistic studies to estimate the probability between variables.</p><p><strong>Results: </strong>27 men and 11 women (n = 38) were included. Of these, 22 had unilateral and 16 bilateral nasolacrimal duct involvement. Lund-Mackay score range: 2-20. Eleven patients had associated pathology. The most affected were anterior and maxillary ethmoidal sinus (69%), osteomeatal complex (68%), posterior ethmoidal (51%). Patients with severe rhinosinusitis are 12 times more likely to develop dacryocystitis than patients with < 12 points. Men presented greater severity, affectation, and clinical repercussion.</p><p><strong>Conclusions: </strong>There is radiological rhinosinusal involvement in dacryocystitis, which must be evaluated and treated preoperatively to avoid postoperative complications or reinfections.</p>","PeriodicalId":50990,"journal":{"name":"Cirugia Y Cirujanos","volume":"91 1","pages":"87-93"},"PeriodicalIF":0.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10732239","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Volumen plaquetario medio e índice de plaquetas-linfocitos como factores de pronóstico en cáncer papilar de tiroides. 平均血小板体积和血小板淋巴细胞指数是甲状腺乳头状癌的预后因素。
IF 0.5 4区 医学 Q4 SURGERY Pub Date : 2023-01-01 DOI: 10.24875/CIRU.21000470
Jesús E Mendoza-Hernández, Luis M Hurtado-López, Erich O P Basurto-Kuba, Edgar R Montes de Oca-Durán, Felipe R Zaldívar-Ramírez, Abraham Pulido-Cejudo

Background: Papillary thyroid cancer is the most common endocrine neoplasia. There are prognostic factors that establish risk of recurrence and mortality; however, patients considered low risk may have a less favorable evolution and hence the importance of finding new markers.

Objective: To assess whether the mean platelet volume (MPV) and the platelet-lymphocyte index (PLI) show a relationship with the clinical staging in papillary thyroid cancer.

Method: Retrospective, observational and analytical study. Preoperative MPV and PLI were recorded, its relationship with TNM and MACIS systems was sought, as well as locally advanced invasion and tumor focality.

Results: 107 cases treated from November 2017 to February 2020. No statistically significant difference was observed in these two preoperative parameters with advanced and initial stages, risk groups or tumor focality. The statistical analysis used was one-way ANOVA with SPSS 25, a 95% confidence interval and p < 0.05.

Conclusions: Despite the logical reasoning of tumor pathophysiology, our study did not find a relationship between papillary thyroid carcinoma with MPV and PLI, and should be complemented with more extensive studies.

背景:甲状腺乳头状癌是最常见的内分泌肿瘤。存在确定复发和死亡风险的预后因素;然而,被认为低风险的患者可能有不太有利的进化,因此寻找新的标记物很重要。目的:探讨平均血小板体积(MPV)和血小板淋巴细胞指数(PLI)与甲状腺乳头状癌临床分期的关系。方法:回顾性、观察性、分析性研究。术前记录MPV和PLI,寻求其与TNM和MACIS系统的关系,以及局部晚期侵袭和肿瘤病灶。结果:2017年11月至2020年2月共治疗107例。这两项术前参数与早期、晚期、危险人群、肿瘤病灶均无统计学差异。统计学分析采用SPSS 25进行单因素方差分析,95%置信区间,p < 0.05。结论:尽管从肿瘤病理生理上进行了合理的推理,但我们的研究并没有发现甲状腺乳头状癌与MPV和PLI之间的关系,需要更广泛的研究来补充。
{"title":"Volumen plaquetario medio e índice de plaquetas-linfocitos como factores de pronóstico en cáncer papilar de tiroides.","authors":"Jesús E Mendoza-Hernández,&nbsp;Luis M Hurtado-López,&nbsp;Erich O P Basurto-Kuba,&nbsp;Edgar R Montes de Oca-Durán,&nbsp;Felipe R Zaldívar-Ramírez,&nbsp;Abraham Pulido-Cejudo","doi":"10.24875/CIRU.21000470","DOIUrl":"https://doi.org/10.24875/CIRU.21000470","url":null,"abstract":"<p><strong>Background: </strong>Papillary thyroid cancer is the most common endocrine neoplasia. There are prognostic factors that establish risk of recurrence and mortality; however, patients considered low risk may have a less favorable evolution and hence the importance of finding new markers.</p><p><strong>Objective: </strong>To assess whether the mean platelet volume (MPV) and the platelet-lymphocyte index (PLI) show a relationship with the clinical staging in papillary thyroid cancer.</p><p><strong>Method: </strong>Retrospective, observational and analytical study. Preoperative MPV and PLI were recorded, its relationship with TNM and MACIS systems was sought, as well as locally advanced invasion and tumor focality.</p><p><strong>Results: </strong>107 cases treated from November 2017 to February 2020. No statistically significant difference was observed in these two preoperative parameters with advanced and initial stages, risk groups or tumor focality. The statistical analysis used was one-way ANOVA with SPSS 25, a 95% confidence interval and p < 0.05.</p><p><strong>Conclusions: </strong>Despite the logical reasoning of tumor pathophysiology, our study did not find a relationship between papillary thyroid carcinoma with MPV and PLI, and should be complemented with more extensive studies.</p>","PeriodicalId":50990,"journal":{"name":"Cirugia Y Cirujanos","volume":"91 1","pages":"79-86"},"PeriodicalIF":0.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10748374","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prognostic value of KI-67 proliferation index in luminal breast cancers. KI-67增殖指数在腔内乳腺癌中的预后价值。
IF 0.5 4区 医学 Q4 SURGERY Pub Date : 2023-01-01 DOI: 10.24875/CIRU.22000043
Şeref Dokcu, Mehmet Ali-Çaparlar, Özhan Çetindağ, Musluh Hakseven, Aydan Eroğlu

Aim: This study aimed to examine the prognostic significance of the KI-67 proliferation index, especially in breast cancer (BC) patients without HER-2 expression and no nodal involvement.

Material and methods: The database of hormone-receptor-positive patients who underwent surgery for BC in our Surgical Oncology Clinic between 2008 and 2020 was retrospectively reviewed and recorded. Patients were categorized based on their KI-67 level, considering the cutoff value of 20%.

Results: Our study revealed that tumors with high KI-67 levels were more likely to have a more advanced histological grade (p = 0.00) and size (p = 0.038). In the univariant analysis, KI-67 level was effective on overall survival (p = 0.044) and disease-free survival (p = 0.048). However, we found that there was no independent prognostic factor in the multivariant analysis.

Conclusion: Although the Ki-67 proliferation index does not yet have an agreed threshold value and scoring methodology, it can also be used to determine prognosis and evaluate treatment response in some patients.

目的:本研究旨在探讨KI-67增殖指数在无HER-2表达和无淋巴结累及的乳腺癌(BC)患者中的预后意义。材料和方法:回顾性回顾和记录2008年至2020年在我院外科肿瘤诊所接受BC手术的激素受体阳性患者数据库。根据KI-67水平,考虑20%的临界值对患者进行分类。结果:我们的研究显示,KI-67水平高的肿瘤更有可能具有更高的组织学分级(p = 0.00)和更大的肿瘤(p = 0.038)。在单变量分析中,KI-67水平对总生存期(p = 0.044)和无病生存期(p = 0.048)有效。然而,我们发现在多变量分析中没有独立的预后因素。结论:虽然Ki-67增殖指数尚未有统一的阈值和评分方法,但在部分患者中,Ki-67增殖指数也可用于判断预后和评价治疗反应。
{"title":"Prognostic value of KI-67 proliferation index in luminal breast cancers.","authors":"Şeref Dokcu,&nbsp;Mehmet Ali-Çaparlar,&nbsp;Özhan Çetindağ,&nbsp;Musluh Hakseven,&nbsp;Aydan Eroğlu","doi":"10.24875/CIRU.22000043","DOIUrl":"https://doi.org/10.24875/CIRU.22000043","url":null,"abstract":"<p><strong>Aim: </strong>This study aimed to examine the prognostic significance of the KI-67 proliferation index, especially in breast cancer (BC) patients without HER-2 expression and no nodal involvement.</p><p><strong>Material and methods: </strong>The database of hormone-receptor-positive patients who underwent surgery for BC in our Surgical Oncology Clinic between 2008 and 2020 was retrospectively reviewed and recorded. Patients were categorized based on their KI-67 level, considering the cutoff value of 20%.</p><p><strong>Results: </strong>Our study revealed that tumors with high KI-67 levels were more likely to have a more advanced histological grade (p = 0.00) and size (p = 0.038). In the univariant analysis, KI-67 level was effective on overall survival (p = 0.044) and disease-free survival (p = 0.048). However, we found that there was no independent prognostic factor in the multivariant analysis.</p><p><strong>Conclusion: </strong>Although the Ki-67 proliferation index does not yet have an agreed threshold value and scoring methodology, it can also be used to determine prognosis and evaluate treatment response in some patients.</p>","PeriodicalId":50990,"journal":{"name":"Cirugia Y Cirujanos","volume":"91 1","pages":"1-8"},"PeriodicalIF":0.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9297158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Does perivascular fibrin glue application have a preventive effect for the endothelial damage on saphenous vein graft? An experimental model. 血管周围纤维蛋白胶对大隐静脉移植内皮损伤有预防作用吗?实验模型。
IF 0.5 4区 医学 Q4 SURGERY Pub Date : 2023-01-01 DOI: 10.24875/CIRU.22000142
Serdar Badem, Nail Kahraman, Ezgi Isil-Turhan, Temmuz Taner, Deniz Demir, Didem Melis-Oztas, Murat Ugurlucan

Background: The effect of tissue adhesives on coronary grafts in cardiac surgery is a controversial issue.

Objective: The aim of this study is to investigate the effect of fibrin glue (FG) applied around the saphenous vein grafts (SVG) in preventing cellular damage resulting from intraluminal pressure increase.

Methods: Twenty volunteer patients were included in this ex vivo study. The SVGs remained after coronary artery bypass grafting were connected to the arterial line of the cardiopulmonary bypass circuit. The grafts were divided into two segments and one segment received perivascular FG applied whereas the other part was used plain. SVGs were kept in circulation at 120 mmHg pressure 250 mL/min flow rate for 60 min. The tissues were sent for histopathological examination to determine the endothelial damage.

Results: Endothelial damage was more pronounced in the control group when compared with the FG group. In the FG group, no damage was seen in 13 samples and no Type 3 endothelial damage was observe whereas Type 1 injury was detected in seven specimens, Type 2 injury was observed in seven specimens, and Type 3 injury was detected in two specimens in the control group.

Conclusion: Perivascular application of FG on the SVG showed a protective effect against endothelial damage resulting from increased intraluminal pressure.

背景:组织粘接剂对心脏手术冠状动脉移植的影响是一个有争议的问题。目的:探讨纤维蛋白胶(FG)在隐静脉移植物(SVG)周围的应用对预防腔内压力升高引起的细胞损伤的作用。方法:20例自愿接受体外实验的患者。冠状动脉旁路移植术后的svg与体外循环的动脉线相连。将移植物分为两段,一段血管周围灌注FG,另一段血管周围灌注FG。将svg在120 mmHg压力250 mL/min流速下循环60 min。送组织进行组织病理学检查,以确定内皮损伤情况。结果:与FG组相比,对照组内皮损伤更明显。FG组13例未见损伤,未见3型内皮损伤,对照组1型损伤7例,2型损伤7例,3型损伤2例。结论:FG在SVG血管周围应用,对腔内压力升高引起的内皮损伤具有保护作用。
{"title":"Does perivascular fibrin glue application have a preventive effect for the endothelial damage on saphenous vein graft? An experimental model.","authors":"Serdar Badem,&nbsp;Nail Kahraman,&nbsp;Ezgi Isil-Turhan,&nbsp;Temmuz Taner,&nbsp;Deniz Demir,&nbsp;Didem Melis-Oztas,&nbsp;Murat Ugurlucan","doi":"10.24875/CIRU.22000142","DOIUrl":"https://doi.org/10.24875/CIRU.22000142","url":null,"abstract":"<p><strong>Background: </strong>The effect of tissue adhesives on coronary grafts in cardiac surgery is a controversial issue.</p><p><strong>Objective: </strong>The aim of this study is to investigate the effect of fibrin glue (FG) applied around the saphenous vein grafts (SVG) in preventing cellular damage resulting from intraluminal pressure increase.</p><p><strong>Methods: </strong>Twenty volunteer patients were included in this ex vivo study. The SVGs remained after coronary artery bypass grafting were connected to the arterial line of the cardiopulmonary bypass circuit. The grafts were divided into two segments and one segment received perivascular FG applied whereas the other part was used plain. SVGs were kept in circulation at 120 mmHg pressure 250 mL/min flow rate for 60 min. The tissues were sent for histopathological examination to determine the endothelial damage.</p><p><strong>Results: </strong>Endothelial damage was more pronounced in the control group when compared with the FG group. In the FG group, no damage was seen in 13 samples and no Type 3 endothelial damage was observe whereas Type 1 injury was detected in seven specimens, Type 2 injury was observed in seven specimens, and Type 3 injury was detected in two specimens in the control group.</p><p><strong>Conclusion: </strong>Perivascular application of FG on the SVG showed a protective effect against endothelial damage resulting from increased intraluminal pressure.</p>","PeriodicalId":50990,"journal":{"name":"Cirugia Y Cirujanos","volume":"91 2","pages":"212-217"},"PeriodicalIF":0.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9477332","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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Cirugia Y Cirujanos
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