Pub Date : 2025-10-31DOI: 10.1016/j.ijosm.2025.100797
Laura Eccott , Andrea Moulson , Karen Atkinson , Salvatore Livatino , Jeremy Lewis , Mindy Cairns
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Pub Date : 2025-10-30DOI: 10.1016/j.ijosm.2025.100795
Daniel Orchard , Dominic Bolt , Thomas Pinna , Gabriel Antoni-Pineda
Introduction
With an ageing population and limited efficacy of analgesics, alternative strategies for managing chronic musculoskeletal (MSK) pain in older adults are required. Osteopathy is frequently used by people aged 65 and over and may offer a viable non-pharmacological approach.
Objective
To evaluate the feasibility and acceptability of a 12-week course of osteopathy in older adults with chronic MSK pain.
Methods
A single-arm, prospective, pre–post feasibility study was conducted with twenty participants aged 65+. Feasibility was examined across treatment delivery, study procedures, and methodological processes. Acceptability was assessed using patient-reported experience measures of care quality, treatment satisfaction, and likelihood of recommendation. Secondary outcomes explored potential effects on pain, physical function, quality of life, mental wellbeing, and loneliness, using the Symptom Severity Scale, PSFS, MSK-HQ, SWEMWBS, and UCLA Loneliness Scale, respectively. Data were also used to inform sample size calculations for a definitive future trial.
Results
The intervention demonstrated adequate feasibility and acceptability, with high satisfaction ratings and attrition within acceptable thresholds. Improvements were observed in physical function and quality of life. Sample size calculations indicated that 46 participants would be required in the intervention arm to detect a clinically meaningful MSK-HQ difference in subsequent studies.
Conclusion
A short course of osteopathy for older adults with chronic MSK pain appears feasible and acceptable, with early evidence suggesting benefits in function and quality of life. A larger trial is warranted to confirm these findings and assess clinical effectiveness.
Implications for practice
•
A short course of osteopathy showed good feasibility and acceptability for older adults with chronic musculoskeletal pain.
•
Six sessions of osteopathy may improve quality of life and function at 3-months when assessed using the MSK-HQ and PSFS.
•
Osteopathy, alongside pain education, exercise and self-care, may improve quality of life in older adults with chronic pain.
{"title":"The outcome of a short course of osteopathy for older adults with chronic musculoskeletal (MSK) pain. A single-arm, prospective feasibility study","authors":"Daniel Orchard , Dominic Bolt , Thomas Pinna , Gabriel Antoni-Pineda","doi":"10.1016/j.ijosm.2025.100795","DOIUrl":"10.1016/j.ijosm.2025.100795","url":null,"abstract":"<div><h3>Introduction</h3><div>With an ageing population and limited efficacy of analgesics, alternative strategies for managing chronic musculoskeletal (MSK) pain in older adults are required. Osteopathy is frequently used by people aged 65 and over and may offer a viable non-pharmacological approach.</div></div><div><h3>Objective</h3><div>To evaluate the feasibility and acceptability of a 12-week course of osteopathy in older adults with chronic MSK pain.</div></div><div><h3>Methods</h3><div>A single-arm, prospective, pre–post feasibility study was conducted with twenty participants aged 65+. Feasibility was examined across treatment delivery, study procedures, and methodological processes. Acceptability was assessed using patient-reported experience measures of care quality, treatment satisfaction, and likelihood of recommendation. Secondary outcomes explored potential effects on pain, physical function, quality of life, mental wellbeing, and loneliness, using the Symptom Severity Scale, PSFS, MSK-HQ, SWEMWBS, and UCLA Loneliness Scale, respectively. Data were also used to inform sample size calculations for a definitive future trial.</div></div><div><h3>Results</h3><div>The intervention demonstrated adequate feasibility and acceptability, with high satisfaction ratings and attrition within acceptable thresholds. Improvements were observed in physical function and quality of life. Sample size calculations indicated that 46 participants would be required in the intervention arm to detect a clinically meaningful MSK-HQ difference in subsequent studies.</div></div><div><h3>Conclusion</h3><div>A short course of osteopathy for older adults with chronic MSK pain appears feasible and acceptable, with early evidence suggesting benefits in function and quality of life. A larger trial is warranted to confirm these findings and assess clinical effectiveness.</div></div><div><h3>Implications for practice</h3><div><ul><li><span>•</span><span><div>A short course of osteopathy showed good feasibility and acceptability for older adults with chronic musculoskeletal pain.</div></span></li><li><span>•</span><span><div>Six sessions of osteopathy may improve quality of life and function at 3-months when assessed using the MSK-HQ and PSFS.</div></span></li><li><span>•</span><span><div>Osteopathy, alongside pain education, exercise and self-care, may improve quality of life in older adults with chronic pain.</div></span></li></ul></div></div>","PeriodicalId":51068,"journal":{"name":"International Journal of Osteopathic Medicine","volume":"58 ","pages":"Article 100795"},"PeriodicalIF":1.5,"publicationDate":"2025-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145465541","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-10-27DOI: 10.1016/j.ijosm.2025.100794
Xianjun Jiang , Liuqian Yu , Yanfang Yan , Shuning Zhou , Qi Zheng
Objectives
This meta-analysis aimed to evaluate the effectiveness of exercise in reducing fatigue, pain, and improving functional status in patients with rheumatoid arthritis (RA).
Methods
Two independent reviewers conducted an extensive literature search in PubMed, Embase, the Cochrane Library, and Web of Science databases up to August 5, 2024. The review included randomized controlled trials (RCTs) comparing exercise interventions with non-exercise controls in RA patients.
Results
Nine RCTs involving 631 RA patients (358 in the exercise group, 273 in the control group) were included. Exercise significantly reduced fatigue (SMD = −0.71, P = 0.02) and pain (SMD = −0.24, P = 0.008). However, the improvement in functional status (MD = −0.23, P = 0.09) did not reach statistical significance. High heterogeneity was observed for fatigue (I2 = 90 %) and functional status (I2 = 57 %), likely due to variations in study design and sample size.
Conclusions
Exercise significantly reduces fatigue and pain in RA patients, reinforcing its role in comprehensive disease management. Further research is needed to establish optimal exercise protocols and compare them with other therapeutic options to refine RA management strategies.
目的:本荟萃分析旨在评估运动在减轻类风湿性关节炎(RA)患者疲劳、疼痛和改善功能状态方面的有效性。方法两位独立审稿人在PubMed、Embase、Cochrane Library和Web of Science数据库中进行了广泛的文献检索,检索时间截止到2024年8月5日。该综述包括随机对照试验(rct),比较RA患者的运动干预和非运动对照。结果共纳入9项随机对照试验,共纳入631例RA患者,其中运动组358例,对照组273例。运动显著减少疲劳(SMD = - 0.71, P = 0.02)和疼痛(SMD = - 0.24, P = 0.008)。而功能状态的改善(MD = - 0.23, P = 0.09)无统计学意义。在疲劳(I2 = 90%)和功能状态(I2 = 57%)方面观察到高度异质性,可能是由于研究设计和样本量的差异。结论运动可明显减轻RA患者的疲劳和疼痛,增强其在疾病综合管理中的作用。需要进一步的研究来建立最佳的运动方案,并将其与其他治疗方案进行比较,以完善RA的管理策略。
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Pub Date : 2025-10-09DOI: 10.1016/j.ijosm.2025.100793
Timothy Lathlean , Paul Orrock , Rebecca Malon , Timothy McNamara , Jade Tan , Rechu Divakar , Lee Barclay , Cathy Woodward , Eva Saar
Objective
To identify factors associated with the retention and attrition of regulated osteopaths in Australia.
Methods
An online survey of osteopaths and a retrospective analysis of 10 years of Australian Health Practitioner Regulation Agency (Ahpra) osteopath registration data.
Results
Among surveyed osteopaths, 629 (79.2 %) intended to renew their registration, 85 (10.7 %) intended to leave, and 60 (7.6 %) were unsure. The most common reasons for staying registered included flexible work-life balance (73 %), enjoyment or fulfilling and meaningful work (69 %) and a sense of achievement (58 %). Main factors that would encourage osteopaths to stay were remuneration (60 %), opportunities for career progression (43.5 %) and a flexible work/life balance (28.2 %). Osteopaths with 5 or less years’ experience and those that on casual/temporary contracts were more likely to leave. Analysis of Ahpra registration data from 2014 to 2023, showed that the number of registered osteopaths per 100,000 population increased by 57.0 %, but the number of new osteopaths entering or returning to the profession for each one that leaves decreased by 39 %, indicating higher overall numbers but lower replacement rates.
Conclusions
While the overall number of osteopaths increased from 2014 to 2023, the replacement rate declined, highlighting concerns about potential workforce stability, particularly among osteopaths with 5 or less years’ experience as well as those in casual or temporary employment. Addressing intrinsic workplace factors such as remuneration, opportunities for career progression and a flexible work-life balance may help to encourage more osteopaths to stay in the profession.
{"title":"Trends in retention and attrition among osteopaths in Australia: Insights from the workforce retention and Attrition Project","authors":"Timothy Lathlean , Paul Orrock , Rebecca Malon , Timothy McNamara , Jade Tan , Rechu Divakar , Lee Barclay , Cathy Woodward , Eva Saar","doi":"10.1016/j.ijosm.2025.100793","DOIUrl":"10.1016/j.ijosm.2025.100793","url":null,"abstract":"<div><h3>Objective</h3><div>To identify factors associated with the retention and attrition of regulated osteopaths in Australia.</div></div><div><h3>Methods</h3><div>An online survey of osteopaths and a retrospective analysis of 10 years of Australian Health Practitioner Regulation Agency (Ahpra) osteopath registration data.</div></div><div><h3>Results</h3><div>Among surveyed osteopaths, 629 (79.2 %) intended to renew their registration, 85 (10.7 %) intended to leave, and 60 (7.6 %) were unsure. The most common reasons for staying registered included flexible work-life balance (73 %), enjoyment or fulfilling and meaningful work (69 %) and a sense of achievement (58 %). Main factors that would encourage osteopaths to stay were remuneration (60 %), opportunities for career progression (43.5 %) and a flexible work/life balance (28.2 %). Osteopaths with 5 or less years’ experience and those that on casual/temporary contracts were more likely to leave. Analysis of Ahpra registration data from 2014 to 2023, showed that the number of registered osteopaths per 100,000 population increased by 57.0 %, but the number of new osteopaths entering or returning to the profession for each one that leaves decreased by 39 %, indicating higher overall numbers but lower replacement rates.</div></div><div><h3>Conclusions</h3><div>While the overall number of osteopaths increased from 2014 to 2023, the replacement rate declined, highlighting concerns about potential workforce stability, particularly among osteopaths with 5 or less years’ experience as well as those in casual or temporary employment. Addressing intrinsic workplace factors such as remuneration, opportunities for career progression and a flexible work-life balance may help to encourage more osteopaths to stay in the profession.</div></div>","PeriodicalId":51068,"journal":{"name":"International Journal of Osteopathic Medicine","volume":"58 ","pages":"Article 100793"},"PeriodicalIF":1.5,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145415786","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-10-03DOI: 10.1016/j.ijosm.2025.100792
François Rosenzweig , Rémi Feruglio , Thibault Marin
Palpation is a cornerstone of osteopathic practice, serving both diagnostic and therapeutic purposes. In France, the professionalization of osteopathy accelerated in 2014, when regulatory decrees mandated structured, competency-based teaching. This aligns with broader trends in science education emphasizing curriculum academization, professional collaboration, and skills-oriented learning. Among the six core competencies in osteopathy, “Performing an osteopathic intervention” includes palpation, assessed on precision, relevance, and clinical efficacy. Pedagogical guidelines underscore the need to regularly update teaching methods in light of scientific advances.
Physiologically, palpation involves complex neurobiological mechanisms. Specialized receptors in the fingertips process shape, pressure, and vibration, while affective touch engages psychoemotional dimensions that can influence therapeutic outcomes. Targeted training improves inter-examiner reproducibility and may even induce structural brain changes.
From an educational perspective, socio-constructivist and professionalization frameworks are particularly relevant. They highlight the interplay between individual development, guided practice, and communal learning. Students benefit from sensitive training and cognitive scaffolding that fosters reflection and skill refinement.
Beyond individual effort, peer learning and mentorship are equally vital. Interactions with teachers and peers nurture shared values, feedback, and role modeling, all of which reinforce confidence and self-efficacy. The emergence of a shared vocabulary and use of standardized tools further support diagnostic precision.
Ultimately, palpation is a technical skill embedded in social meaning and professional identity. Its development contributes to integrating learners into the osteopathic community of practice. As a structured, evidence-based, and patient-centered modality, palpation continues to evolve within a broader network of clinicians and educators.
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Pub Date : 2025-09-28DOI: 10.1016/j.ijosm.2025.100789
Brian Tuckey
Since the publication of “Jones Strain and Counterstrain” in 1995, there have been few documented methodological advancements in Counterstrain. However, over the past 20 years, Strain and Counterstrain (SCS) has been systematically expanded from a primarily musculoskeletal technique to a novel, multisystem evaluation and treatment method called Fascial Counterstrain (FCS). This expanded version of Counterstrain targets dysfunction of both the peripheral and central nervous system, including somatic, visceral, vascular and neuromeningeal tissues. Its proposed mechanisms are supported by emerging clinical and pre-clinical research related to central sensitization, the proprioceptive/contractile properties of fascia, and the science of microvascular dysfunction. In addition to describing FCS's diagnostic and treatment processes, this manuscript also presents an updated theoretical mechanism of action for Counterstrain technique. Finally, for clinical context, a case report (with video documentation) is included of a post-surgical and complex regional pain syndrome patient who failed to respond to multiple medical interventions, yet demonstrated rapid subjective, objective, and functional improvement following FCS treatment.
自1995年出版“Jones Strain and Counterstrain”以来,Counterstrain在方法上的进展很少。然而,在过去的20年里,应变和反应变(SCS)已经系统地从主要的肌肉骨骼技术扩展到一种新的,多系统的评估和治疗方法,称为筋膜反应变(FCS)。这种扩展版的反张力针对外周和中枢神经系统的功能障碍,包括躯体、内脏、血管和神经脑膜组织。其提出的机制得到了与中枢致敏、筋膜本体感觉/收缩特性和微血管功能障碍科学相关的新兴临床和临床前研究的支持。除了描述FCS的诊断和治疗过程外,本文还提出了反应变技术的最新理论作用机制。最后,在临床背景下,一个病例报告(带视频文件)包括一个术后和复杂的局部疼痛综合征患者,该患者对多种医疗干预无效,但在FCS治疗后表现出快速的主观、客观和功能改善。
{"title":"Fascial Counterstrain: A methodological advancement in indirect osteopathic manipulation","authors":"Brian Tuckey","doi":"10.1016/j.ijosm.2025.100789","DOIUrl":"10.1016/j.ijosm.2025.100789","url":null,"abstract":"<div><div>Since the publication of “Jones Strain and Counterstrain” in 1995, there have been few documented methodological advancements in Counterstrain. However, over the past 20 years, Strain and Counterstrain (SCS) has been systematically expanded from a primarily musculoskeletal technique to a novel, multisystem evaluation and treatment method called <em>Fascial Counterstrain (FCS)</em>. This expanded version of Counterstrain targets dysfunction of both the peripheral and central nervous system, including somatic, visceral, vascular and neuromeningeal tissues. Its proposed mechanisms are supported by emerging clinical and pre-clinical research related to central sensitization, the proprioceptive/contractile properties of fascia, and the science of microvascular dysfunction. In addition to describing FCS's diagnostic and treatment processes, this manuscript also presents an updated theoretical mechanism of action for Counterstrain technique. Finally, for clinical context, a case report (with video documentation) is included of a post-surgical and complex regional pain syndrome patient who failed to respond to multiple medical interventions, yet demonstrated rapid subjective, objective, and functional improvement following FCS treatment.</div></div>","PeriodicalId":51068,"journal":{"name":"International Journal of Osteopathic Medicine","volume":"58 ","pages":"Article 100789"},"PeriodicalIF":1.5,"publicationDate":"2025-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145519741","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-09-26DOI: 10.1016/j.ijosm.2025.100791
Rosalba Courtney , Zoe Steele , Imogen Collyer
Background
Long COVID continues to have health impacts globally. Dyspnoea, fatigue, exercise intolerance and musculoskeletal symptoms are common and have been linked to pathophysiological mechanisms such as dysfunctional breathing, dysautonomia and neurolymphatic dysfunction that might be assisted by breathing retraining and manual therapy.
Objective
This review sought to identify research describing breathing retraining and manual therapy protocols that might be beneficial for long COVID.
Methods
A literature review was undertaken to identify research describing treatment protocols that included either manual therapy or breathing retraining approaches for long COVID.
Results
There were 17 articles that fit the inclusion criteria; 9 randomised control trials, 4 case series, 3 uncontrolled studies, and one case report. Whilst methodologies varied, all implemented interventions and reported outcomes involving breathing re-training and/or manual therapy, in four broad categories: manual therapy, singing-based breathing protocols, respiratory muscle training – device assisted, and breathing techniques.
Conclusion
Clinical protocols integrating multimodal interventions and patient self-care should be refined through pilot studies targeting specific phenotypes. High-quality research is needed to compare intervention effectiveness and assess long-term outcomes.
{"title":"Breathing retraining and manual therapy for long COVID – A literature review","authors":"Rosalba Courtney , Zoe Steele , Imogen Collyer","doi":"10.1016/j.ijosm.2025.100791","DOIUrl":"10.1016/j.ijosm.2025.100791","url":null,"abstract":"<div><h3>Background</h3><div>Long COVID continues to have health impacts globally. Dyspnoea, fatigue, exercise intolerance and musculoskeletal symptoms are common and have been linked to pathophysiological mechanisms such as dysfunctional breathing, dysautonomia and neurolymphatic dysfunction that might be assisted by breathing retraining and manual therapy.</div></div><div><h3>Objective</h3><div>This review sought to identify research describing breathing retraining and manual therapy protocols that might be beneficial for long COVID.</div></div><div><h3>Methods</h3><div>A literature review was undertaken to identify research describing treatment protocols that included either manual therapy or breathing retraining approaches for long COVID.</div></div><div><h3>Results</h3><div>There were 17 articles that fit the inclusion criteria; 9 randomised control trials, 4 case series, 3 uncontrolled studies, and one case report. Whilst methodologies varied, all implemented interventions and reported outcomes involving breathing re-training and/or manual therapy, in four broad categories: manual therapy, singing-based breathing protocols, respiratory muscle training – device assisted, and breathing techniques.</div></div><div><h3>Conclusion</h3><div>Clinical protocols integrating multimodal interventions and patient self-care should be refined through pilot studies targeting specific phenotypes. High-quality research is needed to compare intervention effectiveness and assess long-term outcomes.</div></div>","PeriodicalId":51068,"journal":{"name":"International Journal of Osteopathic Medicine","volume":"58 ","pages":"Article 100791"},"PeriodicalIF":1.5,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145465542","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
<div><h3>Background</h3><div>Osteoarthritis (OA) is a chronic degenerative disorder mainly affecting the knee joint.</div></div><div><h3>Objective</h3><div>The objective of the study was to evaluate the effectiveness of manual therapy (MT) with neuromuscular training (NMT) and conventional physical therapy (CPT) with NMT for chronic knee OA.</div></div><div><h3>Methods</h3><div>Randomized, double-blinded controlled study design conducted at government hospitals for the period of 12 months. Sixty subjects aged 40 and 70 were randomly assigned into experimental (MT + NMT) and control (CPT + NMT) groups using the block randomization method. The outcome measures are pain, Knee Flexion ROM, disability, balance, and quality of life, which were measured at baseline, three and six weeks. The effects of treatment were examined utilizing separate 2-by-3 mixed-model analyses of variance using SPSS 25.0.</div></div><div><h3>Results</h3><div>Demographic characteristics such as age, gender, height and weight did not show any statistically significant differences between the groups (p > 0.05). The experimental group (EG) showed a significant reduction in pain compared to the control group (CG) after 3 weeks of intervention (mean between-group difference 1.5 (95 %CI: 1.21to1.78). This was maintained during a 6-week follow-up of 2.6 (95 %CI: 2.31–2.88). At three weeks, patients showed a significantly greater flexion ROM improvement in the EG as well as in the six-week follow-up. Similarly, functional disability, balance and quality of life were significantly better in the EG at the 3 and 6-week follow-ups respectively.</div></div><div><h3>Conclusions</h3><div>Our study results showed a significant improvement in the clinical outcomes following the application of manual therapy with neuromuscular training in managing chronic Knee Osteoarthritis.</div><div><strong><em>Clinical significance of the study:</em></strong> The clinical significance of studies on OA knee physical therapy for researchers, physicians, and patients resides in the potential to optimize care, reduce pain and disability, and enhance quality of life. Research shows the efficacy of exercise therapy and educational programs in enhancing clinical practice, empowering patients in self-management, and reducing healthcare costs.</div><div><strong><em>For researchers:</em></strong> Research on physical therapy for OA knee contributes to the growing body of evidence supporting targeted therapies, such as exercise therapy and educational programs. Recent studies inform physical therapy practices, creating an essential evidence base for developing and refining clinical recommendations. This research can identify the most effective types of exercises, appropriate dosages, and delivery methods tailored to various subgroups of individuals with knee OA.</div><div><strong><em>For clinicians:</em></strong> By employing evidence-based therapies, clinicians can enhance measures of outcomes, such as pain, mobil
{"title":"Effectiveness of manual therapy vs conventional physical therapy with neuromuscular training in the management of knee osteoarthritis: A randomized clinical controlled trial","authors":"Shahul Hameed Pakkir Mohamed , Hani Fahad Albalawi , Gopal Nambi , Kholood Matouq Shalabi , Mohammed Obaid Albalawi","doi":"10.1016/j.ijosm.2025.100787","DOIUrl":"10.1016/j.ijosm.2025.100787","url":null,"abstract":"<div><h3>Background</h3><div>Osteoarthritis (OA) is a chronic degenerative disorder mainly affecting the knee joint.</div></div><div><h3>Objective</h3><div>The objective of the study was to evaluate the effectiveness of manual therapy (MT) with neuromuscular training (NMT) and conventional physical therapy (CPT) with NMT for chronic knee OA.</div></div><div><h3>Methods</h3><div>Randomized, double-blinded controlled study design conducted at government hospitals for the period of 12 months. Sixty subjects aged 40 and 70 were randomly assigned into experimental (MT + NMT) and control (CPT + NMT) groups using the block randomization method. The outcome measures are pain, Knee Flexion ROM, disability, balance, and quality of life, which were measured at baseline, three and six weeks. The effects of treatment were examined utilizing separate 2-by-3 mixed-model analyses of variance using SPSS 25.0.</div></div><div><h3>Results</h3><div>Demographic characteristics such as age, gender, height and weight did not show any statistically significant differences between the groups (p > 0.05). The experimental group (EG) showed a significant reduction in pain compared to the control group (CG) after 3 weeks of intervention (mean between-group difference 1.5 (95 %CI: 1.21to1.78). This was maintained during a 6-week follow-up of 2.6 (95 %CI: 2.31–2.88). At three weeks, patients showed a significantly greater flexion ROM improvement in the EG as well as in the six-week follow-up. Similarly, functional disability, balance and quality of life were significantly better in the EG at the 3 and 6-week follow-ups respectively.</div></div><div><h3>Conclusions</h3><div>Our study results showed a significant improvement in the clinical outcomes following the application of manual therapy with neuromuscular training in managing chronic Knee Osteoarthritis.</div><div><strong><em>Clinical significance of the study:</em></strong> The clinical significance of studies on OA knee physical therapy for researchers, physicians, and patients resides in the potential to optimize care, reduce pain and disability, and enhance quality of life. Research shows the efficacy of exercise therapy and educational programs in enhancing clinical practice, empowering patients in self-management, and reducing healthcare costs.</div><div><strong><em>For researchers:</em></strong> Research on physical therapy for OA knee contributes to the growing body of evidence supporting targeted therapies, such as exercise therapy and educational programs. Recent studies inform physical therapy practices, creating an essential evidence base for developing and refining clinical recommendations. This research can identify the most effective types of exercises, appropriate dosages, and delivery methods tailored to various subgroups of individuals with knee OA.</div><div><strong><em>For clinicians:</em></strong> By employing evidence-based therapies, clinicians can enhance measures of outcomes, such as pain, mobil","PeriodicalId":51068,"journal":{"name":"International Journal of Osteopathic Medicine","volume":"58 ","pages":"Article 100787"},"PeriodicalIF":1.5,"publicationDate":"2025-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145415781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}