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The Relationship Between Autistic Traits, Internet Addiction, Perceived Social Support and Life Satisfaction. 自闭症特质、网络成瘾、感知到的社会支持与生活满意度之间的关系。
IF 1 4区 医学 Q4 CLINICAL NEUROLOGY Pub Date : 2025-02-06 eCollection Date: 2025-01-01 DOI: 10.29399/npa.28752
İdil Umut, Sezen Köse

Introduction: We aimed to examine the relationship between autistic traits, internet addiction and multidimensional perceived social support in individuals aged over 18 years in a non-clinical population sample.

Methods: Volunteers were invited to the study via social media and e-mail, and the data were collected using an online questionnaire form. The research sample consists of 355 participants. The socio-demographic and internet usage information of the participants were collected via the Personal Information Form. Autism-Spectrum Quotient (AQ), Young-Internet Addiction Test (Y-IAT), Multidimensional Scale of Perceived Social Support (MSPSS), and The Satisfaction with Life Scale (SWLS) which were administered to the participants.

Results: As the AQ scores increased, the scores of the Y-IAT also increased, and MSPSS and SWLS scores decreased. According to our results, autistic traits (ATs) were associated with internet addiction, perceived social support and life satisfaction. A positive and significant relationship was found between internet addiction and the sub-dimensions of the autism spectrum questionnaire, such as social skills, shifting attention, attention to detail and communication scores. We stated that 10% of the total variance regarding internet addiction, 8% of the total variance regarding social support and 2% of the total variance regarding life satisfaction are explained by autistic traits. Also, as the level of internet addiction increases, the perceived social support and life satisfaction levels decrease.

Conclusion: Individuals with more ATs are more prone to internet addiction. ATs negatively predicted the perceived social support and life satisfaction. Preventive and therapeutic algorithms need to be developed for individuals with autistic traits.

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引用次数: 0
Beyond the Sound: The Role of the Source of Human-Made Trigger Sounds in Misophonia.
IF 1 4区 医学 Q4 CLINICAL NEUROLOGY Pub Date : 2025-02-06 eCollection Date: 2025-01-01 DOI: 10.29399/npa.28744
Pelinsu Müfreze, Cumhur Avcil, Oğuzhan Herdi

Introduction: Misophonia is a neuropsychiatric disorder characterised by abnormally extreme reactions to certain sensory stimuli. In this paper, we aimed to investigate the effect of the individual producing the human-generated trigger sound on the level of discomfort reported to the trigger sound. Our hypothesis was that when the misophonic sound is presented with the information that it is produced by a relative, it will create more subjective discomfort than the sound presented with the information that is not produced by a relative.

Methods: This experimental study was conducted with 15 participants aged 18-65 years living in Antalya who volunteered to participate in the study.

Results: In the first comparison, participants reported more subjective discomfort when the voice from the sound bank was presented with the information that it was produced by the relative than when the relative's voice was presented with the information that it was not produced by the relative (p<0.001). In the second comparison, participants reported more subjective discomfort when the voice of the relative was presented with the information that it was produced by the relative than when the voice of the relative was presented with the information that it was not produced by the relative (p=0.001). In the final comparison, there was no significant difference in subjective discomfort between presenting the voice of the voice bank with the information that it was produced by the relative and presenting the voice of the relative with the information that it was produced by the relative (p=0.783).

Conclusion: In conclusion, it seems source of the trigger, especially for human-made sounds, is more important than the trigger sound itself.

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引用次数: 0
Evaluation of The Impact of Hypocretin Receptor 1 rs2271933 Polymorphism on Sleep Components in Chronic Migraine Patients with Poor Sleep Quality: A Subgroup Analysis. 下丘脑分泌素受体1 rs2271933多态性对睡眠质量差的慢性偏头痛患者睡眠成分影响的评估:亚组分析
IF 1 4区 医学 Q4 CLINICAL NEUROLOGY Pub Date : 2025-01-17 eCollection Date: 2025-01-01 DOI: 10.29399/npa.28553
Hamit Genç, Emel Ur Özçelik, İbrahim Ömer Barlas, Nevra Öksüz, Aynur Özge

Introductıon: Long-reported dual comorbidity between migraine and sleep disorders suggests that some gene variations may play a role in this relationship. Our previous study found an association between poor sleep quality and the G allele of the hypocretin receptor 1 (HCRTR1) rs2271933 gene in patients with chronic migraine (CM). This study aimed to examine the relationship of this gene with some sleep parameters.

Methods: The present study was designed cross-sectional in the Mersin University Neurology Clinic between January 2000 and February 2018. Patients aged 18-75 years with CM according to the International Classification of Headache Disorders-3 (ICHD-3) criteria were included. The Pittsburgh Sleep Quality Index (PSQI) was used to evaluate the sleep quality of the patients. Patients were divided into two groups according to PSQI scores <6 or ≥6. Genotyping was performed for the HCRTR1 rs2271933 gene.

Results: Among the 100 patients with CM, only the data of those (n=67) with poor sleep quality were included in this study. The mean age of patients was 40.9±11.8%, and the female rate was 89.6%. We detected that increasing the time to fall asleep (p=0.369) and the rate of poor sleep quality (p=0.461) and also shortening sleep duration (p=0.016) with the increase of G allele carrier of HCRTR1 rs2271933 gene.

Conclusıon: As the G allele carrier of the HCRTR1 rs2271933 gene increased, a shorter sleep duration was observed. This finding may contribute to studies on the physiological roles of orexins.

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引用次数: 0
Erratum: Sex-Specific Correlations Between Misophonia Symptoms and ADHD, OCD, and Autism-Related Traits in Adolescent Outpatients. 青少年门诊患者恐音症症状与ADHD、OCD和自闭症相关特征的性别特异性相关性。
IF 1 4区 医学 Q4 CLINICAL NEUROLOGY Pub Date : 2024-12-04 eCollection Date: 2024-01-01 DOI: 10.29399/npa.29005
Oğuzhan Herdi, Fatma Yildirim

[This corrects the article on p. 248 in vol. 61.].

[这是对第61卷第248页的文章的更正]。
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引用次数: 0
Selective Muscle Involvement in Amyotrophic Lateral Sclerosis: Evidence Inferred from the Point of Motor Unit Firing Rates. 肌萎缩侧索硬化症的选择性肌肉受累:从运动单元节律点推断出的证据。
IF 1 4区 医学 Q4 CLINICAL NEUROLOGY Pub Date : 2024-11-30 eCollection Date: 2024-01-01 DOI: 10.29399/npa.28864
Sezin Alpaydın Baslo, Nermin Görkem Şirin, Elif Kocasoy Orhan, Mehmet Barış Baslo, Ali Emre Öge

Introduction: The aim of the study is to determine the role of upper motor neuron (UMN) or lower motor neuron (LMN) dysfunction as the primary initiator of distal-proximal and lateral-medial gradients of muscle involvement in amyotrophic lateral sclerosis (ALS).

Methods: Concentric needle electromyography recordings were performed in deltoid, abductor digiti minimi, and first dorsal interosseous (FDI) muscles in patients with ALS and controls during slight voluntary contraction needed to activate two motor units (MU). Five motor unit potential (MUP) pairs were recorded from each muscle. Motor unit potential analyses were performed offline using Multi-MUP analysis program. Quantitative MUP parameters, MU firing rate (FR), FR variability (FRV), and mean consecutive difference (MCD) were calculated. Motor-evoked potentials and the triple stimulation technique (TST) were performed to evaluate UMN involvement.

Results: Twenty patients with ALS along with 20 age and sex-matched healthy volunteers were enrolled. Quantitative MUP parameters compatible with denervation and reinnervation were found in patients with ALS, who also showed higher FR, FRV, and MCD values, most prominently in FDI. First dorsal interosseous FRV was lower in patients with abnormal central motor conduction time (CMCT). Firing rate and FRV were negatively correlated with CMCT, but not with TST.

Conclusion: Distal limb muscles, particularly FDI, revealed more prominent FR abnormalities in patients with ALS in parallel with the distal-proximal and lateral-medial gradients of the selective muscle involvement pattern which seems predominantly to be correlated with LMN dysfunction. Reduced FRV may be associated with the presence of UMN dysfunction in ALS.

简介:该研究的目的是确定上运动神经元(UMN)或下运动神经元(LMN)功能障碍作为肌萎缩性侧索硬化症(ALS)中肌肉受累的远端-近端和外侧-内侧梯度的主要发起者的作用。方法:对肌萎缩侧索硬化症(ALS)患者和对照组的三角肌、小指外展肌和第一背骨间肌(FDI)进行同心针肌电记录,以激活两个运动单元(MU)。每块肌肉记录5个运动单位电位对。使用Multi-MUP分析程序离线进行运动单元电位分析。计算定量MUP参数、MU发射率(FR)、FR变异性(FRV)和平均连续差(MCD)。运动诱发电位和三重刺激技术(TST)评估UMN受累情况。结果:20名ALS患者和20名年龄和性别匹配的健康志愿者被纳入研究。在ALS患者中发现了与去神经支配和再神经支配相容的定量MUP参数,这些患者也表现出更高的FR、FRV和MCD值,最明显的是FDI。第一背骨间FRV在中枢运动传导时间(CMCT)异常的患者中较低。射速和FRV与CMCT呈负相关,与TST无显著负相关。结论:ALS患者远端肢体肌肉,特别是FDI,显示出更突出的FR异常,与选择性肌肉受累模式的远端-近端和外侧-内侧梯度平行,这似乎主要与LMN功能障碍相关。FRV降低可能与肌萎缩侧索硬化症患者UMN功能障碍有关。
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引用次数: 0
Radiologic and Clinical Characteristics of Stroke Patients with Covid-19: A Case-Control Study. 脑卒中患者Covid-19的影像学和临床特征:一项病例-对照研究
IF 1 4区 医学 Q4 CLINICAL NEUROLOGY Pub Date : 2024-11-30 eCollection Date: 2024-01-01 DOI: 10.29399/npa.28642
Mine Sezgin, Esme Ekizoğlu, Nilufer Yeşilot, Oğuzhan Çoban

Intoduction: A severe infection such as COVID-19 may trigger a stroke. The imaging and clinical features of patients with COVID-19 are not well-defined. We aimed to analyze neuroimaging and clinical features of stroke patients with COVID-19.

Methods: The demographic and clinical data of 21 stroke cases with confirmed COVID-19 (StrokeCov) between April 2020-May 2021 were collected prospectively. An experienced stroke neurologist evaluated neuroimaging findings. A control group of gender, age, and risk factors adjusted 104 stroke patients were included.

Results: Mean age was 66.3 (±13.3) and 66.2 (±13) years in the StrokeCov group and control group (CG), with similar male-to-female ratios (85%) and without significant difference regarding diabetes, hypertension, hyperlipidemia, and atrial fibrillation between groups (p>0.05). Infarcts were most frequently seen in the territory of middle cerebral artery (8 patients; 40%), followed by multiple arterial territories (6 patients; 30%). Ischemic lesions were more frequently localized in both anterior and posterior vascular systems in StrokeCov group (3 patients; 15%) in comparison to CG (2 patients; 2%; p=0.02). Although, hemorrhagic transformation was observed more frequently in StrokeCov group (6 patients; 30%) than CG (11 patients; 10%; p=0.02); statistically significant difference was not seen in terms of acute and preventive treatments given to both groups. The mRS scores on discharge were worse in the StrokeCov group (p<0.00).

Conclusion: Ischemic stroke lesions in StrokeCov group are more likely to be localized on multiple arterial territories and develop hemorrhagic transformation. Poor clinical outcome and in-hospital death are more common in stroke due to COVID-19.

诱导:COVID-19 等严重感染可能引发中风。COVID-19 患者的影像学和临床特征尚不明确。我们旨在分析 COVID-19 中风患者的神经影像学和临床特征:方法:前瞻性地收集了 2020 年 4 月至 2021 年 5 月期间 21 例确诊 COVID-19 的脑卒中病例(StrokeCov)的人口统计学和临床数据。由经验丰富的卒中神经科医生评估神经影像学结果。对照组包括性别、年龄和风险因素调整后的104名中风患者:StrokeCov组和对照组(CG)的平均年龄分别为66.3(±13.3)岁和66.2(±13)岁,男女比例相似(85%),组间在糖尿病、高血压、高脂血症和心房颤动方面无显著差异(P>0.05)。脑梗塞最常见于大脑中动脉区域(8 名患者,占 40%),其次是多动脉区域(6 名患者,占 30%)。与 CG 组(2 名患者;2%;P=0.02)相比,StrokeCov 组(3 名患者;15%)缺血性病变更多发生在前后血管系统。虽然 StrokeCov 组(6 名患者;30%)比 CG 组(11 名患者;10%;P=0.02)更容易观察到出血性转变,但两组患者在急性期治疗和预防性治疗方面没有明显的统计学差异。StrokeCov 组患者出院时的 mRS 评分较低(P=0.01):StrokeCov组的缺血性卒中病变更有可能发生在多个动脉区域,并出现出血性转化。COVID-19导致的卒中临床预后差和院内死亡更为常见。
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引用次数: 0
Lithium Intoxication After Sleeve Gastrectomy: A Case Report and Differential Diagnosis. 袖状胃切除术后的锂中毒:病例报告与鉴别诊断。
IF 1 4区 医学 Q4 CLINICAL NEUROLOGY Pub Date : 2024-11-30 eCollection Date: 2024-01-01 DOI: 10.29399/npa.28653
Zeliha Dönmez, Şiirnaz Kükürt, Gonca Dokuz, Ozge Kilic, Furkan Coşkun, Erkan Yardımcı, İsmet Kırpınar

Bariatric surgery rates have been increasing in the treatment of obesity worldwide recently. In addition to many physical changes after bariatric surgery, the bioavailability of medications can also be significantly affected. In this article, we present a 51-year-old female patient diagnosed with lithium toxicity after sleeve gastrectomy surgery. The patient started to show gastrointestinal symptoms post-surgery after 37 days. She was initially followed up with the diagnosis of gastroenteritis and continued to use lithium. Subsequently, neurological symptoms were added, and she was diagnosed with lithium toxicity. During the toxicity treatment, elevated mood were also observed. We aimed to emphasize the importance of post-bariatric surgery follow-up for patients undergoing psychiatric treatments, especially those using lithium, focusing on both medication management and monitoring of clinical symptoms.

近来,全球范围内治疗肥胖症的减肥手术率不断上升。减肥手术后除了身体会发生很多变化外,药物的生物利用度也会受到很大影响。在本文中,我们介绍了一名在袖状胃切除术后被诊断为锂中毒的 51 岁女性患者。患者在手术后 37 天开始出现胃肠道症状。她最初被诊断为肠胃炎并继续使用锂。随后,她又出现了神经系统症状,被诊断为锂中毒。在毒性治疗期间,还观察到了情绪升高。我们旨在强调对接受精神治疗的患者,尤其是使用锂的患者进行减肥手术后随访的重要性,重点是药物管理和临床症状监测。
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引用次数: 0
The Causality Spectrum of Dropped Head Syndrome is Broad and Includes Myopathy, Neurodegenerative Disorders, and Varia. 垂头综合征的病因谱很广,包括肌病、神经退行性疾病和变异。
IF 1 4区 医学 Q4 CLINICAL NEUROLOGY Pub Date : 2024-11-30 eCollection Date: 2024-01-01 DOI: 10.29399/npa.28520
Josef Finsterer, Sounira Mehri

Dropped head syndrome is a common complication of various neurological disorders. Most commonly, dropped head syndrome is due to primary or secondary myopathy. However, neurodegenerative diseases and various other conditions can also be complicated by dropped head syndrome. Among the primary myopathies, dropped head occurs most commonly in association with mitochondrial disorders, congenital myasthenic syndrome, and axial myopathies. Among the secondary myopathies, dropped occurs most commonly in association with inflammatory myopathies. Myasthenia is the most common transmission disorder associated with dropped head syndrome. The neurodegenerative disorder most commonly associated with dropped head syndrome is Parkinson syndrome. The diagnosis and treatment of dropped head syndrome from any cause requires a multidisciplinary approach. Outcome varies considerably but early diagnosis and early treatment are associated with a more favourable outcome.

垂头综合征是各种神经系统疾病的常见并发症。最常见的是,垂头综合征是由原发性或继发性肌病引起的。然而,神经退行性疾病和各种其他疾病也可能因低头综合征而复杂化。在原发性肌病中,头下垂最常与线粒体疾病、先天性肌无力综合征和轴性肌病有关。在继发性肌病中,下降最常与炎症性肌病相关。重症肌无力是与低下头综合征相关的最常见的传播障碍。与低垂头综合征最常见的神经退行性疾病是帕金森综合征。任何原因引起的头下垂综合征的诊断和治疗需要多学科的方法。结果差异很大,但早期诊断和早期治疗与更有利的结果相关。
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引用次数: 0
Meta-Analysis of the Efficacy of Risperidone Treatment in Patients with First-Episode Schizophrenia. 利培酮治疗首发精神分裂症疗效的meta分析。
IF 1 4区 医学 Q4 CLINICAL NEUROLOGY Pub Date : 2024-11-30 eCollection Date: 2024-01-01 DOI: 10.29399/npa.28712
Hua Yang, Haili Wu

Introduction: First-episode schizophrenia is a prevalent psychiatric disorder with a complex etiology. This meta-analysis evaluates the efficacy of risperidone in treating patients with first-episode schizophrenia.

Methods: A literature search was conducted to identify studies on the efficacy of risperidone for first-episode schizophrenia. The literature was evaluated for quality, and a meta-analysis was then performed.

Results: A total of 15 articles (6 in Chinese and 9 in English) were included. The meta-analysis revealed statistically significant differences in the cure rate (relative risk [RR]=0.51, 95% confidence interval [CI]: 0.46-0.57, p <0.001) and the total marked improvement rate (RR=0.58, 95% CI: 0.52-0.65, p <0.001) favoring risperidone over control groups. The incidence of weight gain (p <0.001) and extrapyramidal symptoms (p=0.005) was higher with risperidone.

Conclusion: Risperidone shows increased cure and effective rates compared with control groups (including placebo and other antipsychotics) in the treatment of patients with first-episode schizophrenia. However, it may increase the risk of extrapyramidal reactions and weight gain.

导言首发精神分裂症是一种病因复杂的常见精神疾病。本荟萃分析评估了利培酮治疗首发精神分裂症患者的疗效:方法:我们进行了文献检索,以确定利培酮对首发精神分裂症疗效的研究。对文献进行了质量评估,然后进行了荟萃分析:结果:共收录了 15 篇文章(中文 6 篇,英文 9 篇)。荟萃分析显示,治愈率的差异具有统计学意义(相对风险 [RR]=0.51, 95% 置信区间 [CI]:0.46-0.57, p 结论:与对照组(包括安慰剂和其他抗精神病药物)相比,利培酮治疗首发精神分裂症患者的治愈率和有效率均有所提高。然而,它可能会增加锥体外系反应和体重增加的风险。
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引用次数: 0
The Influence of Survival Context and Psychological Markers on Recall. 生存情境和心理标记对回忆的影响。
IF 1 4区 医学 Q4 CLINICAL NEUROLOGY Pub Date : 2024-11-28 eCollection Date: 2024-01-01 DOI: 10.29399/npa.28724
Filiz Sayar

Introduction: Research shows that stimuli rated for their relevance to a survival scenario have a higher recall probability when compared to other deep encoding conditions. This phenomenon, known as survival memory advantage, is a robust finding that has been demonstrated by various experimental manipulations. The current study aimed to examine associations between participants' psychological markers (perceived stress, anxiety, coping, cognitive control, and flexibility) and their memory performance in survival and other encoding conditions (fight, flight, and pleasantness).

Methods: A total of 141 undergraduates aged 18-35 years participated voluntarily in the study. Four scenario situations (fight, flight, survival, or pleasantness) were randomly allocated to participants, and then they were given a list of words to rate for their relevance to the scenarios. Participants were given a free recall task to measure their memory, while some psychological scales (perceived stress, anxiety level, coping strategies, cognitive control, and flexibility) were administered to assess their psychological markers.

Results: Survival conditions yielded the highest correct recall. Pairwise comparisons showed that difference between survival and pleasant conditions was significant (p<0.05). The other conditions did not differ significantly from one another. Regression analyses revealed that anxiety level may explain 13% of variance in survival condition and 14% of variance in fight condition. No significant effect was found on flight conditions.

Conclusion: Recall performance did not significantly differ between survival, fight, and flight conditions. However, anxiety level in survival conditions and support seeking in fight condition were found to be negative predictors of recollection. According to these results, associations between concepts of anxiety and survival, and between support seeking and fight (struggle) in human mind determine memory processes at a significant level. Individuals' psychological characteristics and coping strategies have different effects on recall depending on the context.

研究表明,与其他深度编码条件相比,被评为与生存情景相关的刺激具有更高的回忆概率。这种现象被称为生存记忆优势,是一个强有力的发现,已被各种实验操作证明。目前的研究旨在检查参与者的心理标记(感知压力、焦虑、应对、认知控制和灵活性)与他们在生存和其他编码条件(战斗、逃跑和愉悦)下的记忆表现之间的联系。方法:共有141名18-35岁的大学生自愿参与研究。四种情景情景(战斗、逃跑、生存或愉快)被随机分配给参与者,然后给他们一份单词列表,让他们根据与这些情景的相关性进行评分。参与者通过自由回忆任务来测量他们的记忆力,同时使用一些心理量表(感知压力、焦虑水平、应对策略、认知控制和灵活性)来评估他们的心理标记。结果:生存条件产生最高的正确回忆率。两两比较表明,生存条件和愉快条件之间的差异是显著的(结论:回忆表现在生存条件、战斗条件和飞行条件之间没有显著差异。生存状态下的焦虑水平和战斗状态下的支持寻求水平是记忆的负向预测因子。根据这些结果,人类思维中焦虑和生存概念之间、寻求支持和斗争(斗争)之间的联系在很大程度上决定了记忆过程。个体心理特征和应对策略对记忆的影响因情境而异。
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引用次数: 0
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Noropsikiyatri Arsivi-Archives of Neuropsychiatry
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