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Geo-psychiatry: an Emerging New Discipline in Psychiatry. 地理精神病学:一门新兴的精神病学学科。
IF 1 4区 医学 Q4 CLINICAL NEUROLOGY Pub Date : 2024-11-28 eCollection Date: 2024-01-01 DOI: 10.29399/npa.28906
Afzal Javed, Albert Persaud
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引用次数: 0
Childhood Traumas, Attachment Styles and Related Clinical Factors in Opioid Use Disorder. 阿片类药物使用障碍中的童年创伤、依恋方式和相关临床因素。
IF 1 4区 医学 Q4 CLINICAL NEUROLOGY Pub Date : 2024-11-28 eCollection Date: 2024-01-01 DOI: 10.29399/npa.28708
Müge Topcuoğlu, Mustafa Nogay Coşkun, Ali Erdoğan, Burak Kulaksızoğlu

Introduction: The study aims to compare childhood traumas, attachment styles, impulsivity, and quality of life of Opioid Use Disorder (OUD) patients in remission with healthy controls and to reveal the relationships between these parameters.

Methods: The study included one hundred patients diagnosed with OUD and one hundred healthy volunteers. Sociodemographic data form, Structured Clinical Interview for DSM-5 Disorders Clinician Version, Childhood Trauma Questionnaire, Relationship Scales Questionnaire, Barratt Impulsivity Scale-11, World Health Organization Quality of Life Scale Brief Version and Substance Craving Scale were administered.

Results: Emotional abuse, physical abuse, physical neglect, and emotional neglect scores were higher in the OUD group (p<0.001, p=0.004, p<0.001, p=0.005, respectively). Attachment styles were found to be similar in the OUD and healthy control groups. A comparison of quality of life scores revealed that general health, physical health, and social relationships subscale scores were lower in the OUD group (p=0.001, p<0.001, p<0.001, respectively). Unplanned impulsivity scores were higher in the OUD (p<0.001). Logistic regression analysis found strong associations between age, smoking, physical neglect, and unplanned impulsivity with opioid use.

Conclusion: The patients with OUD have a lower quality of life and experience more childhood trauma. Attachment styles in OUD appear similar to healthy controls. Age, smoking, physical neglect, and unplanned impulsivity have strong associations with opioid use.

简介:本研究旨在比较阿片类药物使用障碍(OUD)缓解期患者与健康对照组的童年创伤、依恋方式、冲动性和生活质量,并揭示这些参数之间的关系:本研究旨在比较缓解期阿片类药物使用障碍(OUD)患者与健康对照者的童年创伤、依恋方式、冲动性和生活质量,并揭示这些参数之间的关系:研究对象包括 100 名确诊为阿片类药物使用障碍的患者和 100 名健康志愿者。研究采用了社会人口学数据表、DSM-5 疾病临床医师版结构化临床访谈、童年创伤问卷、关系量表问卷、巴拉特冲动量表-11、世界卫生组织生活质量量表简易版和药物渴求量表:结果:OUD 组的情感虐待、身体虐待、身体忽视和情感忽视得分较高(p):结论:OUD 患者的生活质量较低,童年创伤经历较多。OUD 患者的依恋方式与健康对照组相似。年龄、吸烟、身体忽视和计划外冲动与阿片类药物的使用密切相关。
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引用次数: 0
Comparison of Serum USP9x and TGF-β Levels in Children with Autism Spectrum Disorders with Healthy Controls. 自闭症谱系障碍儿童与健康对照组血清USP9x和TGF-β水平的比较
IF 1 4区 医学 Q4 CLINICAL NEUROLOGY Pub Date : 2024-11-28 eCollection Date: 2024-01-01 DOI: 10.29399/npa.28650
Mehmet Karadağ, Fatma Subaşı Turgut, Zehra Çiftçi, Zehra Hangül, Seyithan Taysi

Introduction: USP9X has been associated with neurodevelopmental disorders due to its role in synaptic development and neural function. This study aimed to compare USP9X and TGF-β levels in children with autism and healthy controls, and explore their relationship with autism severity.

Methods: Serum USP9X and TGF-β levels were measured in 41 healthy control children (aged 3-12 years) and 41 children with autism.

Results: Our study revealed a significant increase in USP9X levels (p=0.001) among children with autism compared to controls. However, TGF-β levels showed no significant difference between the two groups. Furthermore, we observed a positive correlation between difficulty in making eye contact subscale and blood levels of both USP9X and TGF-β.

Conclusions: This study is the first to compare serum USP9X levels in children with autism to healthy controls. Our findings suggest USP9X's potential role in autism development, emphasizing the need for further research on its involvement in neurodevelopmental processes.

简介:由于USP9X在突触发育和神经功能中的作用,它与神经发育障碍有关。本研究旨在比较自闭症儿童和健康对照组的 USP9X 和 TGF-β 水平,并探讨它们与自闭症严重程度的关系:41名健康对照组儿童(3-12岁)和41名自闭症儿童的血清USP9X和TGF-β水平:我们的研究发现,与对照组相比,自闭症儿童的 USP9X 水平明显升高(p=0.001)。然而,两组儿童的 TGF-β 水平无明显差异。此外,我们还观察到,自闭症儿童在进行眼神交流时遇到的困难与血液中 USP9X 和 TGF-β 的水平呈正相关:本研究首次比较了自闭症儿童与健康对照组的血清 USP9X 水平。我们的研究结果表明,USP9X 在自闭症的发展过程中具有潜在作用,因此有必要进一步研究 USP9X 在神经发育过程中的作用。
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引用次数: 0
Multidisciplinary Evaluation of Heart Transplantation and Ventricular Assist Device Implantation in a Child with Autism Spectrum Disorder. 自闭症谱系障碍儿童心脏移植和心室辅助装置植入的多学科评估。
IF 1 4区 医学 Q4 CLINICAL NEUROLOGY Pub Date : 2024-11-28 eCollection Date: 2024-01-01 DOI: 10.29399/npa.28647
Burcu Özbaran, Didem Çek, Nurhak Doğan, Oğuzhan Ay, Zülal Ülger Tutar, Mustafa Özbaran

Organ transplantation practices have witnessed tremendous advances all over the world and in Türkiye in recent years, and the pre-transplantation preparation, operation and postoperative follow-up procedures are being meticulously handled. However, there is very limited information about follow-up processes of pediatric patients with autism spectrum disorder (ASD) undergoing organ transplantation. Furthermore, it is difficult to manage the arduous and long-term care and follow-up processes in ASD cases undergoing organ transplantation. In this case report, an 11-year-old male patient with a diagnosis of ASD and attention deficit-hyperactivity disorder (ADHD) was reviewed psychiatrically for the suitability of ventricular assist device (VAD) implantation and heart transplantation, and the multidisciplinary council process was evaluated. The council decided that the case was suitable for heart transplantation but not suitable for long-term intracorporeal device implantation due to behaviors such as plucking wounds, playing with vascular access, and being nervous about vascular access. The council stated that due to sensory hypersensitivity of the case, implantation of such a device may further increase anxiety, and involuntary damage to the device may result in personal harm. We hope that this case report will guide future endeavors to develop devices suitable for cases with ASD or other behavioral problems.

近年来,全世界和土耳其的器官移植实践都取得了巨大进步,移植前准备、手术和术后随访程序都得到了精心处理。然而,有关接受器官移植的自闭症谱系障碍(ASD)儿科患者随访过程的信息非常有限。此外,对接受器官移植的自闭症谱系障碍病例进行艰巨而长期的护理和随访过程也很难管理。在本病例报告中,我们对一名被诊断为自闭症谱系障碍(ASD)和注意力缺陷多动障碍(ADHD)的11岁男性患者进行了精神病学审查,以确定其是否适合植入心室辅助装置(VAD)和进行心脏移植,并对多学科委员会的程序进行了评估。委员会决定,该病例适合心脏移植,但不适合长期体外装置植入,原因是其有拨弄伤口、玩弄血管通路和对血管通路感到紧张等行为。理事会表示,由于该病例感觉过敏,植入这种装置可能会进一步增加焦虑,对装置的非自愿损坏可能会造成人身伤害。我们希望本病例报告能为今后开发适用于 ASD 或其他行为问题病例的装置提供指导。
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引用次数: 0
The Validity and Reliability Study of TONI-3 Test for 4-17 Aged Children. 4-17岁儿童TONI-3测验的效度与信度研究
IF 1 4区 医学 Q4 CLINICAL NEUROLOGY Pub Date : 2024-11-25 eCollection Date: 2024-01-01 DOI: 10.29399/npa.28522
Ahmet Bildiren, Tahsin Fırat, Sevinç Zeynep Kavruk

Introduction: Since there are not enough scales to evaluate the cognitive performance of adolescents in Türkiye, the aim of this study is to conduct a reliability and validity study of the Test of Nonverbal Intelligence-3 (TONI-3) for individuals aged between 14 and 17.

Methods: A total of 566 children between the ages of 14-17 were included in the study. A form of TONI-3 test was administered to all participants. Test-retest and parallel form application were made for reliability analyses, and Raven Standard Progressive Matrices Test (RSPM) and Naglieri Nonverbal Ability Test (NNAT-I) tests were applied for validity analyses.

Results: It has been found that the TONI-3 Test has a high reliability with an average reliability coefficient of 0.92. It was determined that there was a high, positive and significant relationship between Form A and Form B of the TONI-3 Test (r=0.76, p<0.01). The correlation coefficient between the scores was found to be 0.83 between the first application of the TONI-3 test and the test repeated after 4 weeks. A high, positive and significant correlation was found between TONI-3 Test, RSPM Test and NNAT-I (r=0.69, p<0.01; r=0.81, p<0.01).

Conclusion: This study revealed evidence of the reliability and validity of the TONI-3 test between the ages of 14-17. This is the first study of the TONI-3 test in this age group. It is thought that clinicians can practically evaluate cognitive abilities in children who are clinically referred to or determined to have behavior disorders at school through this test.

摘要:由于 rkiye青少年认知能力的评估量表不够,本研究的目的是对14 - 17岁青少年的非语言智力测验-3 (TONI-3)进行信度和效度研究。方法:选取14 ~ 17岁儿童566例。对所有参与者进行TONI-3测试。信度分析采用重测法和平行表格法,效度分析采用Raven标准递进矩阵测验(RSPM)和Naglieri非语言能力测验(NNAT-I)。结果:TONI-3测验具有较高的信度,平均信度系数为0.92。结果表明,TONI-3量表a、B表之间存在高度正相关(r=0.76, p)。结论:本研究为14-17岁青少年TONI-3量表的信度和效度提供了证据。这是TONI-3测试在这个年龄段的首次研究。据认为,临床医生可以实际评估儿童的认知能力,谁被临床提及或确定有行为障碍在学校通过这个测试。
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引用次数: 0
Clinical Neurology Research Output From Türkiye: A Bibliometric Analysis. 来自<s:1> rkiye的临床神经学研究成果:文献计量分析。
IF 1 4区 医学 Q4 CLINICAL NEUROLOGY Pub Date : 2024-11-25 eCollection Date: 2024-01-01 DOI: 10.29399/npa.28462
Seden Demirci, Fatma Yardibi

Introduction: Bibliometric analysis is a comprehensive method used to investigate the academic impact and characteristics of publications in a research field. It has been widely used in various fields of medicine. However, bibliometric analysis of publications in the field of clinical neurology from Türkiye has not yet been evaluated. In this study, we aimed to analyze the publications in the field of clinical neurology in the last decade from Türkiye using the bibliometric method and network analysis and to determine research trends and key issues.

Methods: We carried out a search of the Web of Science Core Collection database for articles. CiteSpace Advances 6.1. R 1 and VOSviewer (version 1.6.9) were used for bibliometric analyses and visualization.

Results: The research data consisted of 8404 articles in the category of the clinical neurology from Türkiye between 2012 and 2022. The number of publications rose over time, with a mean annual growth rate of 6%. From the document co-citation analysis, chronic migraine and mental health clusters were active current areas. From the keywords analysis, endovascular treatment, depression, oxidative stress, Parkinson's disease, epilepsy, multiple sclerosis, and ischemic stroke were active clusters. Analysis of the authors showed that the most active authors were Betul Baykan, Cavit Boz, and Erdem Tuzun, and MS was the most active topic in this area and recent trend.

Conclusions: Clinical neurology is a rapidly expanding research area and attracting more and more attention from the authors. Our study can provide researchers who study the clinical neurology with valuable information on the current status and trends in this field and to facilitate for future studies.

文献计量分析是研究某一研究领域出版物的学术影响和特征的综合方法。它已被广泛应用于医学的各个领域。然而,文献计量学分析的出版物在临床神经病学领域从 rkiye尚未评估。本研究旨在运用文献计量学方法和网络分析法,对 rkiye杂志近十年来临床神经病学领域的出版物进行分析,以确定研究趋势和关键问题。方法:我们在Web of Science Core Collection数据库中检索文章。CiteSpace advanced 6.1。使用r1和VOSviewer (version 1.6.9)进行文献计量分析和可视化。结果:研究数据包括2012年至2022年期间来自 rkiye临床神经病学类别的8404篇文章。随着时间的推移,出版物的数量不断增加,年平均增长率为6%。从文献共被引分析来看,慢性偏头痛和精神健康集群是当前活跃的领域。从关键词分析来看,血管内治疗、抑郁、氧化应激、帕金森病、癫痫、多发性硬化症、缺血性脑卒中是活跃簇。作者分析显示,最活跃的作者是Betul Baykan、Cavit Boz和Erdem Tuzun, MS是该领域最活跃的话题和最新趋势。结论:临床神经病学是一个快速发展的研究领域,越来越受到作者的关注。我们的研究可以为临床神经病学研究人员提供有价值的信息,了解该领域的现状和趋势,为今后的研究提供参考。
{"title":"Clinical Neurology Research Output From Türkiye: A Bibliometric Analysis.","authors":"Seden Demirci, Fatma Yardibi","doi":"10.29399/npa.28462","DOIUrl":"10.29399/npa.28462","url":null,"abstract":"<p><strong>Introduction: </strong>Bibliometric analysis is a comprehensive method used to investigate the academic impact and characteristics of publications in a research field. It has been widely used in various fields of medicine. However, bibliometric analysis of publications in the field of clinical neurology from Türkiye has not yet been evaluated. In this study, we aimed to analyze the publications in the field of clinical neurology in the last decade from Türkiye using the bibliometric method and network analysis and to determine research trends and key issues.</p><p><strong>Methods: </strong>We carried out a search of the Web of Science Core Collection database for articles. CiteSpace Advances 6.1. R 1 and VOSviewer (version 1.6.9) were used for bibliometric analyses and visualization.</p><p><strong>Results: </strong>The research data consisted of 8404 articles in the category of the clinical neurology from Türkiye between 2012 and 2022. The number of publications rose over time, with a mean annual growth rate of 6%. From the document co-citation analysis, chronic migraine and mental health clusters were active current areas. From the keywords analysis, endovascular treatment, depression, oxidative stress, Parkinson's disease, epilepsy, multiple sclerosis, and ischemic stroke were active clusters. Analysis of the authors showed that the most active authors were Betul Baykan, Cavit Boz, and Erdem Tuzun, and MS was the most active topic in this area and recent trend.</p><p><strong>Conclusions: </strong>Clinical neurology is a rapidly expanding research area and attracting more and more attention from the authors. Our study can provide researchers who study the clinical neurology with valuable information on the current status and trends in this field and to facilitate for future studies.</p>","PeriodicalId":51142,"journal":{"name":"Noropsikiyatri Arsivi-Archives of Neuropsychiatry","volume":"23 1 1","pages":"313-323"},"PeriodicalIF":1.0,"publicationDate":"2024-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11638577/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76811006","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cognitive Dysfunction in Multiple Sclerosis Patients with Hippocampal Antibodies. 多发性硬化症患者海马抗体的认知功能障碍。
IF 1 4区 医学 Q4 CLINICAL NEUROLOGY Pub Date : 2024-11-25 eCollection Date: 2024-01-01 DOI: 10.29399/npa.28734
Erdil Arsoy, Hande Yüceer, Beyzanur Yalçın, Sedat Günbek, Melike Tezel, Recai Türkoğlu, Erdem Tüzün
{"title":"Cognitive Dysfunction in Multiple Sclerosis Patients with Hippocampal Antibodies.","authors":"Erdil Arsoy, Hande Yüceer, Beyzanur Yalçın, Sedat Günbek, Melike Tezel, Recai Türkoğlu, Erdem Tüzün","doi":"10.29399/npa.28734","DOIUrl":"10.29399/npa.28734","url":null,"abstract":"","PeriodicalId":51142,"journal":{"name":"Noropsikiyatri Arsivi-Archives of Neuropsychiatry","volume":"61 4","pages":"293-295"},"PeriodicalIF":1.0,"publicationDate":"2024-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11638570/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142830772","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Reliability and Validity of the Turkish versions of the Davos Assessment of Cognitive Biases Scale (DACOBS) and Cognitive Biases Questionnaire for Psychosis (CBQp). 土耳其版达沃斯认知偏差评估量表(DACOBS)和精神病认知偏差问卷(CBQp)的信度和效度。
IF 1 4区 医学 Q4 CLINICAL NEUROLOGY Pub Date : 2024-11-19 eCollection Date: 2024-01-01 DOI: 10.29399/npa.28751
Şükrü Alperen Korkmaz, İlkay Keleş Altun, Serap Sağbaş, Fatmagül Eda Köksalan, Murat İlhan Atagün

Introduction: Cognitive biases can be defined as dysfunctional patterns of thought formation that lead to incorrect conclusions and abnormal perceptions and are critical factors in the development and maintenance of psychosis. Two self-report measures assessing cognitive biases in psychosis spectrum disorder (PSD) have recently been developed: the Davos Assessment of Cognitive Biases Scale (DACOBS) and the Cognitive Biases Questionnaire for Psychosis (CBQp). This study aimed to validate the Turkish versions of the DACOBS and CBQp.

Methods: The sample consisted of 171 patients with PSD and 162 age and sex-matched healthy controls (HC). We investigated I) the factor structure with confirmatory factor analysis (CFA), II) the reliability (internal consistency and test-retest reliability), III) discriminative power, IV) convergent validity, and V) the concurrent validity of DACOBS and CBQp.

Results: The 7-factor solution for DACOBS, similar to the original study, and the 5-factor solution for CBQp provided the best fit. DACOBS and CBQp total and their subscale scores showed good internal consistency and test-retest reliability. DACOBS and CBQp total and their subscale scores could differentiate between PSD patients and HCs when controlling for age, sex, and education. DACOBS and CBQp showed a positively moderate correlation. DACOBS and CBQp scores were associated with psychotic symptoms in PSD patients and positive psychic experiences in HCs.

Conclusions: Both the DACOBS and the CBQp have good psychometric properties and are suitable instruments for assessing cognitive biases in the Turkish population. The Turkish versions of the DACOBS and CBQp were as reliable and valid as the original.

认知偏差可以定义为思维形成的功能失调模式,导致错误的结论和异常的感知,是精神病发展和维持的关键因素。最近出现了两种评估精神病谱系障碍(PSD)认知偏差的自我报告方法:达沃斯认知偏差评估量表(DACOBS)和精神病认知偏差问卷(CBQp)。本研究旨在验证土耳其版本的DACOBS和CBQp。方法:171例PSD患者和162例年龄和性别匹配的健康对照(HC)。我们研究了1)验证性因子分析(CFA)的因子结构,2)信度(内部一致性和重测信度),3)判别力,4)收敛效度,5)DACOBS和CBQp的并发效度。结果:DACOBS的7因子方案与原研究相似,CBQp的5因子方案拟合最佳。DACOBS和CBQp总分及其子量表得分具有良好的内部一致性和重测信度。在控制年龄、性别和教育程度的情况下,DACOBS和CBQp总分及其亚量表得分可以区分PSD患者和hc患者。DACOBS与CBQp呈正相关。DACOBS和CBQp评分与PSD患者的精神病症状和hc患者的积极心理体验相关。结论:DACOBS和CBQp都具有良好的心理测量特性,是评估土耳其人群认知偏差的合适工具。土耳其版本的DACOBS和CBQp与原始版本一样可靠和有效。
{"title":"Reliability and Validity of the Turkish versions of the Davos Assessment of Cognitive Biases Scale (DACOBS) and Cognitive Biases Questionnaire for Psychosis (CBQp).","authors":"Şükrü Alperen Korkmaz, İlkay Keleş Altun, Serap Sağbaş, Fatmagül Eda Köksalan, Murat İlhan Atagün","doi":"10.29399/npa.28751","DOIUrl":"10.29399/npa.28751","url":null,"abstract":"<p><strong>Introduction: </strong>Cognitive biases can be defined as dysfunctional patterns of thought formation that lead to incorrect conclusions and abnormal perceptions and are critical factors in the development and maintenance of psychosis. Two self-report measures assessing cognitive biases in psychosis spectrum disorder (PSD) have recently been developed: the Davos Assessment of Cognitive Biases Scale (DACOBS) and the Cognitive Biases Questionnaire for Psychosis (CBQp). This study aimed to validate the Turkish versions of the DACOBS and CBQp.</p><p><strong>Methods: </strong>The sample consisted of 171 patients with PSD and 162 age and sex-matched healthy controls (HC). We investigated I) the factor structure with confirmatory factor analysis (CFA), II) the reliability (internal consistency and test-retest reliability), III) discriminative power, IV) convergent validity, and V) the concurrent validity of DACOBS and CBQp.</p><p><strong>Results: </strong>The 7-factor solution for DACOBS, similar to the original study, and the 5-factor solution for CBQp provided the best fit. DACOBS and CBQp total and their subscale scores showed good internal consistency and test-retest reliability. DACOBS and CBQp total and their subscale scores could differentiate between PSD patients and HCs when controlling for age, sex, and education. DACOBS and CBQp showed a positively moderate correlation. DACOBS and CBQp scores were associated with psychotic symptoms in PSD patients and positive psychic experiences in HCs.</p><p><strong>Conclusions: </strong>Both the DACOBS and the CBQp have good psychometric properties and are suitable instruments for assessing cognitive biases in the Turkish population. The Turkish versions of the DACOBS and CBQp were as reliable and valid as the original.</p>","PeriodicalId":51142,"journal":{"name":"Noropsikiyatri Arsivi-Archives of Neuropsychiatry","volume":"61 4","pages":"324-331"},"PeriodicalIF":1.0,"publicationDate":"2024-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11638564/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142830780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Fibrotic Response in Pericyte Culture Upon Exposure to Multiple Sclerosis Sera.
IF 1 4区 医学 Q4 CLINICAL NEUROLOGY Pub Date : 2024-11-03 eCollection Date: 2025-01-01 DOI: 10.29399/npa.28791
Emine Şekerdağ-Kılıç, Esra Özkan, Canan Ulusoy, Ege Anıl Uçar, Narges Shomalizadeh, Selin Sapancı, Özgür Öztop-Çakmak, Atay Vural, Cem İsmail Küçükali, Erdem Tüzün, Yasemin Gürsoy-Özdemir

Introduction: Multiple sclerosis (MS) is a chronic autoimmune and demyelinating disease of central nervous system (CNS) leading to progressive function loss. Besides infiltration of peripheral immune cells into CNS subsequent to neuroinflammation, the accumulation of extracellular matrix (ECM) elements, produced by brain barrier cells, in the enlarged perivascular spaces contributes to the pathophysiology. In this study, we aimed to develop an in-vitro model of MS to investigate fibrosis triggered by sera or cerebrospinal fluid (CSF) from MS patients and evaluate the response of blood-brain barrier (BBB) cells to this model.

Methods: Human brain vascular pericytes, endothelial cells and normal human astrocytes were cultured and exposed to a cytokine reference control (Transforming growth factor beta 1 (TGF-β1)), healthy human sera, and sera/CSF from treatment naïve relapsing-remitting MS patients with the appropriate dilution dose. The pericytes cell proliferation were evaluated by xCELLigence, while the collagen and fibronectin expressions of BBB cells, and pericyte myofibroblastic transformation were analyzed with immunocytochemistry.

Results: TGF-β1 induced fibrosis, characterized by fibronectin overexpression, specifically in pericyte cultures. Furthermore, incubation of pericytes with MS serum but not CSF led to a more robust fibrotic response (fibronectin/collagen overexpression), myofibroblastic transformation as well as increased proliferation. Fibronectin overexpression was also detected in endothelial cell culture with MS serum. Glial fibrillary acidic protein (GFAP) expression is increased, but fibrotic markers are decreased in cultured astrocytes with MS serum.

Conclusion: Pericytes, among BBB-forming cells, were identified as key contributors to fibrosis in response to MS serum. MS-serum-induced in vitro models are promising for studying the individualized tendencies of patients and may be a new approach for high-throughput screening of potential treatment agents.

{"title":"The Fibrotic Response in Pericyte Culture Upon Exposure to Multiple Sclerosis Sera.","authors":"Emine Şekerdağ-Kılıç, Esra Özkan, Canan Ulusoy, Ege Anıl Uçar, Narges Shomalizadeh, Selin Sapancı, Özgür Öztop-Çakmak, Atay Vural, Cem İsmail Küçükali, Erdem Tüzün, Yasemin Gürsoy-Özdemir","doi":"10.29399/npa.28791","DOIUrl":"10.29399/npa.28791","url":null,"abstract":"<p><strong>Introduction: </strong>Multiple sclerosis (MS) is a chronic autoimmune and demyelinating disease of central nervous system (CNS) leading to progressive function loss. Besides infiltration of peripheral immune cells into CNS subsequent to neuroinflammation, the accumulation of extracellular matrix (ECM) elements, produced by brain barrier cells, in the enlarged perivascular spaces contributes to the pathophysiology. In this study, we aimed to develop an in-vitro model of MS to investigate fibrosis triggered by sera or cerebrospinal fluid (CSF) from MS patients and evaluate the response of blood-brain barrier (BBB) cells to this model.</p><p><strong>Methods: </strong>Human brain vascular pericytes, endothelial cells and normal human astrocytes were cultured and exposed to a cytokine reference control (Transforming growth factor beta 1 (TGF-β1)), healthy human sera, and sera/CSF from treatment naïve relapsing-remitting MS patients with the appropriate dilution dose. The pericytes cell proliferation were evaluated by xCELLigence, while the collagen and fibronectin expressions of BBB cells, and pericyte myofibroblastic transformation were analyzed with immunocytochemistry.</p><p><strong>Results: </strong>TGF-β1 induced fibrosis, characterized by fibronectin overexpression, specifically in pericyte cultures. Furthermore, incubation of pericytes with MS serum but not CSF led to a more robust fibrotic response (fibronectin/collagen overexpression), myofibroblastic transformation as well as increased proliferation. Fibronectin overexpression was also detected in endothelial cell culture with MS serum. Glial fibrillary acidic protein (GFAP) expression is increased, but fibrotic markers are decreased in cultured astrocytes with MS serum.</p><p><strong>Conclusion: </strong>Pericytes, among BBB-forming cells, were identified as key contributors to fibrosis in response to MS serum. MS-serum-induced in vitro models are promising for studying the individualized tendencies of patients and may be a new approach for high-throughput screening of potential treatment agents.</p>","PeriodicalId":51142,"journal":{"name":"Noropsikiyatri Arsivi-Archives of Neuropsychiatry","volume":"62 1","pages":"69-76"},"PeriodicalIF":1.0,"publicationDate":"2024-11-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11877379/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143568727","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Linc00205/Mir-495-3p/Tnfsf15 Axis is Implicated in the Treatment Effect of Hyperbaric Oxygen Therapy on Patients with Post-Stroke Cognitive Impairment.
IF 1 4区 医学 Q4 CLINICAL NEUROLOGY Pub Date : 2024-10-23 eCollection Date: 2025-01-01 DOI: 10.29399/npa.28530
Xiaoling Yang, Miao Chen, Zuoting Shen, Tianyi Rong, Jialiang Feng, Min Wu, Deyan Chen, Zhenyu Wei

Introduction: We investigated the effects of hyperbaric oxygen (HBO) therapy on post-stroke cognitive impairment (PSCI) and performed the differential profiling of lncRNAs and mRNA.

Methods: The serum levels of different inflammatory factors were detected in PSCI patients with or without HBO therapy. The cognitive functions of patients in different groups were assessed before and after treatment. Differential expression analysis was performed on lncRNAs and mRNAs, followed by functional interaction prediction. The selected candidates were verified by Real-time Quantitative PCR and luciferase reporter assay.

Results: The results of MMSE and MoCA scores showed that patients in both the control (conventional treatment) group and HBO therapy group had significantly higher post-treatment cognitive scores, and in the 6th month after treatment, patients in the HBO group had higher scores than those in the control group. Blood inflammatory factors showed similar results, with the HBO group having higher anti-inflammatory factors IL-4 and IL-10 than the control group, and lower pro-inflammatory factors IL-2, IL-6, TNF-α, IFN-α and IL-17A than the control group. We further identified a competitive endogenous RNA regulator network of LINC00205-hsa-miR-495-3p-TNFSF15 involved in the HBO treatment, and their expression patterns were verified by qRT-PCR.

Conclusion: HBO treatment can improve the cognitive performance of PSCI patients in comparison to conventional treatment scheme. LINC00205/miR-495-3p/TNFSF15 axis may be responsible for the treatment effect of HBO therapy.

{"title":"Linc00205/Mir-495-3p/Tnfsf15 Axis is Implicated in the Treatment Effect of Hyperbaric Oxygen Therapy on Patients with Post-Stroke Cognitive Impairment.","authors":"Xiaoling Yang, Miao Chen, Zuoting Shen, Tianyi Rong, Jialiang Feng, Min Wu, Deyan Chen, Zhenyu Wei","doi":"10.29399/npa.28530","DOIUrl":"10.29399/npa.28530","url":null,"abstract":"<p><strong>Introduction: </strong>We investigated the effects of hyperbaric oxygen (HBO) therapy on post-stroke cognitive impairment (PSCI) and performed the differential profiling of lncRNAs and mRNA.</p><p><strong>Methods: </strong>The serum levels of different inflammatory factors were detected in PSCI patients with or without HBO therapy. The cognitive functions of patients in different groups were assessed before and after treatment. Differential expression analysis was performed on lncRNAs and mRNAs, followed by functional interaction prediction. The selected candidates were verified by Real-time Quantitative PCR and luciferase reporter assay.</p><p><strong>Results: </strong>The results of MMSE and MoCA scores showed that patients in both the control (conventional treatment) group and HBO therapy group had significantly higher post-treatment cognitive scores, and in the 6th month after treatment, patients in the HBO group had higher scores than those in the control group. Blood inflammatory factors showed similar results, with the HBO group having higher anti-inflammatory factors IL-4 and IL-10 than the control group, and lower pro-inflammatory factors IL-2, IL-6, TNF-α, IFN-α and IL-17A than the control group. We further identified a competitive endogenous RNA regulator network of LINC00205-hsa-miR-495-3p-TNFSF15 involved in the HBO treatment, and their expression patterns were verified by qRT-PCR.</p><p><strong>Conclusion: </strong>HBO treatment can improve the cognitive performance of PSCI patients in comparison to conventional treatment scheme. LINC00205/miR-495-3p/TNFSF15 axis may be responsible for the treatment effect of HBO therapy.</p>","PeriodicalId":51142,"journal":{"name":"Noropsikiyatri Arsivi-Archives of Neuropsychiatry","volume":"62 1","pages":"11-19"},"PeriodicalIF":1.0,"publicationDate":"2024-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11877386/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143568724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
Noropsikiyatri Arsivi-Archives of Neuropsychiatry
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