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ONCOLOGÍA (COMUNICACIONES ORALES) 肿瘤学(口语交流)
IF 0.8 4区 医学 Q4 NEUROSCIENCES Pub Date : 2024-05-01 DOI: 10.1016/S1130-1473(24)00061-7
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引用次数: 0
ONCOLOGÍA (PÓSTERES) 肿瘤学(海报)
IF 0.8 4区 医学 Q4 NEUROSCIENCES Pub Date : 2024-05-01 DOI: 10.1016/S1130-1473(24)00063-0
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引用次数: 0
HIDROCEFALIA Y TRASTORNOS DEL LCR (PÓSTERES) 脑积水和 LCR 疾病(海报)
IF 0.8 4区 医学 Q4 NEUROSCIENCES Pub Date : 2024-05-01 DOI: 10.1016/S1130-1473(24)00051-4
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引用次数: 0
CIRUGÍA FUNCIONAL Y ESTEREOTÁXICA (COMUNICACIONES ORALES) 功能和立体定向手术(口头交流)
IF 0.8 4区 医学 Q4 NEUROSCIENCES Pub Date : 2024-05-01 DOI: 10.1016/S1130-1473(24)00039-3
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引用次数: 0
Exposición de la oliva bulbar mediante los abordajes far lateral y retrosigmoideo bajo. Análisis comparativo de la superficie expuesta y ángulo de ataque 使用远外侧和低后穹隆入路暴露球橄榄。暴露面和攻击角的比较分析。
IF 0.8 4区 医学 Q4 NEUROSCIENCES Pub Date : 2024-05-01 DOI: 10.1016/j.neucir.2023.08.001
Pau Capilla-Guasch , Vicent Quilis-Quesada , Félix Pastor-Escartín , Diego Tabarés Palacín , Juan Pablo Valencia Salazar , José M. González-Darder

Objectives

Throughout neurosurgical history, the treatment of intrinsic lesions located in the brainstem has been subject of much controversy. The brainstem is the anatomical structure of the central nervous system (CNS) that presents the highest concentration of nuclei and fibers, and its simple manipulation can lead to significant morbidity and mortality. Once one of the safe entry points at the medulla oblongata has been established, we wanted to evaluate the safest approach to the olivary body (the most used safe entry zone on the anterolateral surface of the medulla oblongata). The proposed objective was to evaluate the working channel from the surface of each of the far lateral and retrosigmoid approaches to the olivary body: distances, angles of attack and channel content.

Material and methods

To complete this work, a total of 10 heads injected with red/blue silicone were used. A total of 40 approaches were made in the 10 heads used (20 retrosigmoid and 20 far lateral). After completing the anatomical study and obtaining the data referring to all the approaches performed, it was decided to expand the sample of this research study by using 30 high-definition magnetic resonance imaging of anonymous patients without cranial or cerebral pathology. The reference points used were the same ones defined in the anatomical study. After defining the working channels in each of the approaches, the working distances, angle of attack, exposed surface, and the number of neurovascular structures present in the central trajectory were analyzed.

Results

The distances to the cranial and medial region of the olivary body were 52.71 mm (SD 3.59) from the retrosigmoid approach and 27.94 mm (SD 3.99) from the far lateral; to the most basal region of the olivary body, the distances were 49.93 (SD 3.72) from the retrosigmoid approach and 18.1 mm (SD 2.5) from the far lateral. The angle of attack to the caudal region was 19.44° (SD 1.3) for the retrosigmoid approach and 50.97° (SD 8.01) for the far lateral approach; the angle of attack to the cranial region was 20.3° (SD 1.22) for the retrosigmoid and 39.9° (SD 5.12) for the far lateral. Regarding neurovascular structures, the probability of finding an arterial structure is higher for the far lateral, whereas a neural structure will be more likely from a retrosigmoid approach.

Conclusions

As conclusions of this work, we can say that far lateral approach presents more favorable conditions for the microsurgical treatment of intrinsic bulbar and bulbomedullary lesions approached through the caudal half of the olivary body. In those cases of bulbar and pontine-bulbar lesions approached through the cranial half of the olivary body, the retrosigmoid approach can be considered for selected cases.

目的在整个神经外科历史上,对位于脑干的内在病变的治疗一直备受争议。脑干是中枢神经系统(CNS)中神经核和神经纤维最密集的解剖结构,对其进行简单操作可能会导致严重的发病率和死亡率。在确定了延髓的一个安全进入点后,我们希望评估进入橄榄体(延髓前外侧表面最常用的安全进入区)的最安全方法。我们提出的目标是评估从橄榄体远外侧和后穹隆入路表面的工作通道:距离、攻击角度和通道内容。材料和方法为了完成这项工作,我们共使用了 10 个注射了红/蓝硅胶的头颅。这 10 个头共使用了 40 个切口(20 个后侧切口和 20 个远侧切口)。在完成解剖学研究并获得所有方法的相关数据后,决定使用 30 个无颅脑病变的匿名患者的高清磁共振成像来扩大这项研究的样本。使用的参考点与解剖研究中定义的参考点相同。在确定每种方法的工作通道后,分析了中心轨迹的工作距离、攻击角度、暴露表面和存在的神经血管结构数量。到橄榄体最基底区域的距离为:从后穹窿入路为 49.93 mm(SD 3.72),从远外侧入路为 18.1 mm(SD 2.5)。后穹隆入路的尾部攻击角度为 19.44°(SD 1.3),远侧入路为 50.97°(SD 8.01);后穹隆入路的颅部攻击角度为 20.3°(SD 1.22),远侧入路为 39.9°(SD 5.12)。就神经血管结构而言,远外侧入路发现动脉结构的概率较高,而从后蝶鞍入路发现神经结构的概率较高。结论作为这项工作的结论,我们可以说,远外侧入路为显微外科治疗从橄榄体尾部入路的球部和球髓部内在病变提供了更有利的条件。对于通过橄榄体头半部进入的球部和蝶髓病变病例,可考虑在选定病例中采用后蝶鞍入路。
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引用次数: 0
Intracerebral hemorrhage after deep brain stimulation surgery guided with microelectrode recording: analysis of 297 procedures 微电极记录引导的脑深部刺激手术后脑出血:对 297 例手术的分析
IF 0.8 4区 医学 Q4 NEUROSCIENCES Pub Date : 2024-03-01 DOI: 10.1016/j.neucir.2023.09.002
Beatriz Dos Santos , Rui Vaz , Ana Cristina Braga , Manuel Rito , Diana Lucas , Clara Chamadoira

Objectives

Report the incidence of symptomatic and asymptomatic intracerebral hemorrhage (ICH) in patients submitted to deep brain stimulation (DBS) guided with microelectrode recording (MER) with further analysis of potential risk factors, both inherent to the patient and related to the pathology and surgical technique.

Methods

We performed a retrospective observational study. 297 DBS procedures were concluded in 277 patients in a single hospital centre between January 2010 and December 2020. All surgeries were guided with MER. We analysed the incidence of symptomatic and asymptomatic ICH and its correlation to age, sex, diagnosis, hypertension and perioperative hypertension, diabetes, dyslipidaemia, antiplatelet drugs, anatomic target, and number of MER trajectories.

Results

There were a total of 585 electrodes implanted in 277 patients. 16 ICH were observed, of which 6 were symptomatic and 10 asymptomatic, none of which incurred in permanent neurological deficit. The location of the hemorrhage varied between cortical and subcortical plans, always in relation with the trajectory or the final position of the electrode. The incidence of symptomatic ICH per lead-implantation was 1%, and the CT-scan demonstrated asymptomatic ICH in 1.7% more patients. Male patients or with hypertension are 2.7 and 2.2 times more likely to develop ICH, respectively. However, none of these characteristics has been shown to have a statistically significant association with the occurrence of ICH, as well as age, diagnosis, diabetes, dyslipidaemia, antiplatelet drugs, anatomic target, number of MER trajectories and perioperative hypertension.

Conclusions

MER-guided DBS is a safe technique, with low incidence of ICH and no permanent deficits in our study. Hypertension and male sex seem to be risk factors for the development of ICH in this surgery. Nevertheless, no statistically significant factors were found for the occurrence of this complication.

目的报告在微电极记录(MER)引导下接受脑深部刺激(DBS)的患者中症状性和无症状性脑内出血(ICH)的发生率,并进一步分析潜在的风险因素,既包括患者本身的因素,也包括与病理和手术技术相关的因素。2010 年 1 月至 2020 年 12 月期间,我们在一家医院中心为 277 名患者完成了 297 例 DBS 手术。所有手术均在 MER 的指导下进行。我们分析了无症状和无症状 ICH 的发生率及其与年龄、性别、诊断、高血压和围手术期高血压、糖尿病、血脂异常、抗血小板药物、解剖靶点和 MER 轨迹数量的相关性。共观察到 16 例 ICH,其中 6 例有症状,10 例无症状,均未造成永久性神经功能缺损。出血位置因皮层和皮层下平面而异,始终与电极的轨迹或最终位置相关。每次导联植入后,无症状 ICH 的发生率为 1%,而 CT 扫描显示无症状 ICH 的患者占 1.7%。男性患者或高血压患者发生 ICH 的几率分别是前者的 2.7 倍和 2.2 倍。然而,这些特征均未被证明与 ICH 的发生有显著的统计学关联,年龄、诊断、糖尿病、血脂异常、抗血小板药物、解剖靶点、MER 轨迹数和围手术期高血压也是如此。高血压和男性似乎是该手术中发生 ICH 的危险因素。尽管如此,在统计学上并未发现发生这种并发症的重要因素。
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引用次数: 0
Ependimomas de fosa posterior de tipo lateral en la edad pediátrica 儿科后窝外侧脑膜瘤
IF 0.8 4区 医学 Q4 NEUROSCIENCES Pub Date : 2024-03-01 DOI: 10.1016/j.neucir.2023.10.002
Pablo Miranda-Lloret, Estela Plaza-Ramírez, Juan Antonio Simal-Julián, Giovanni Pancucci, Adela Cañete, Alejandro Montoya-Filardi, Gemma Llavador

Background and aims

Lateral-type posterior fossa ependymomas are a well-defined subtype of tumors both clinically and pathologically, with a poor prognosis. Their incidence is low and surgical management is challenging. The objective of the present work is to review our series of lateral-tye posterior fossa ependymomas and compare our results with those of previous series.

Materials and methods

Among 30 cases of ependymoma operated in our pediatric department in the last 10 years, we identified seven cases of lateral-type posterior fossa ependymomas. We then performed a retrospective, descriptive study.

Results

Mean age of our patients was 3.75 years. Six cases presented with hydrocephalus. Mean tumor volume at diagnosis was 61 cc. A complete resection was achieved in six cases and a near-total resection in one patient. Five patients transiently required a gastrostomy and a tracheostomy. Mean follow-up was 58 months. One case progressed along this period and eventually died. Four cases of hydrocephalus required a ventriculoperitoneal CSF shunt and two were managed with a third ventriculostomy. At last follow-up four patients carried a normal life and two displayed a mild restriction according to Lansky's scale.

Conclusions

The aim of surgical treatment in lateral-type posterior fossa ependymomas is complete resection. Neurological deficits associated to lower cranial nerve dysfunction are common but transient. Deeper genetic characterization of these tumors may identify risk factors that guide stratification of adjuvant therapies.

背景和目的外侧型后窝外胚瘤在临床和病理上都是一种定义明确的亚型肿瘤,预后较差。其发病率较低,手术治疗具有挑战性。本研究的目的是回顾我们对侧位后窝外胚窦瘤的研究,并将我们的研究结果与之前的研究结果进行比较。材料和方法在过去 10 年中,我们儿科共手术治疗了 30 例外胚窦瘤患者,其中 7 例为侧位型后窝外胚窦瘤。结果患者平均年龄为 3.75 岁。六例患者伴有脑积水。确诊时的平均肿瘤体积为 61 毫升。六名患者实现了完全切除,一名患者接近完全切除。五名患者暂时需要进行胃造口术和气管造口术。平均随访时间为 58 个月。在此期间,一名患者病情恶化,最终死亡。四例脑积水患者需要进行脑室腹腔 CSF 分流术,两例患者进行了第三脑室造口术。在最后的随访中,4 名患者生活正常,2 名患者根据兰斯基量表显示有轻度限制。与下颅神经功能障碍相关的神经功能缺损很常见,但都是一过性的。对这些肿瘤进行更深入的基因鉴定可能会发现风险因素,为分层辅助治疗提供指导。
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引用次数: 0
Fistula espontánea de LCR como manifestación de la hipertensión intracraneal idiopática 作为特发性颅内高压表现的自发性脑脊液瘘
IF 0.8 4区 医学 Q4 NEUROSCIENCES Pub Date : 2024-03-01 DOI: 10.1016/j.neucir.2023.02.001
Samsara López Hernández , Carlos Alberto Rodríguez Arias , Jaime Santos Pérez , Mario Martínez-Galdámez , Adrián Fernández García , Herbert Daniel Jiménez Zapata

Introduction

Spontaneous cerebrospinal fluid (CSF) fistula, of unknown origin, is a rare condition whose etiology is increasingly related to idiopathic intracranial hypertension (IIH). This study tries to raise awareness that they should not be considered as two different processes, but that fistulas can be a form of debut, requiring a study and subsequent treatment. Repair techniques are described, as well as the study of IIH.

Results

We treated eight patients, five women and three men, aged between 46 and 72 years, with a diagnosis of spontaneous CSF fistula, four nasal and four otics who underwent surgical treatment. After repair, a diagnostic study was performed for IIH by MRI and angio-MRI, presenting in all cases a transverse venous sinus stenosis. The intracranial pressure values obtained by lumbar puncture showed values of 20 mmHg or higher. All patients were diagnosed with IIH. The one-year follow-up did not reveal any recurrence of the fistulas, maintaining a control of the IIH.

Conclusion

Despite their low frequency of both cranial CSF fistula and IIH, an association of both conditions should be considered by continuing the study and surveillance of these patients after fistula closure.

导言:原因不明的自发性脑脊液(CSF)瘘是一种罕见病,其病因越来越多地与特发性颅内高压(IIH)有关。本研究试图提高人们的认识,即不应将它们视为两个不同的过程,瘘管可能是一种初次发病的形式,需要进行研究和随后的治疗。结果我们收治了八名诊断为自发性脑脊液瘘的患者,其中五名女性,三名男性,年龄在 46 岁至 72 岁之间,四名鼻部患者和四名耳部患者接受了手术治疗。修复后,通过核磁共振成像和血管核磁共振成像对 IIH 进行了诊断,所有病例均出现横向静脉窦狭窄。腰椎穿刺获得的颅内压值为 20 毫米汞柱或更高。所有患者均被诊断为 IIH。结论尽管头颅脑脊液瘘和 IIH 的发病率都很低,但应考虑到这两种疾病的关联性,在瘘管闭合后继续对这些患者进行研究和监测。
{"title":"Fistula espontánea de LCR como manifestación de la hipertensión intracraneal idiopática","authors":"Samsara López Hernández ,&nbsp;Carlos Alberto Rodríguez Arias ,&nbsp;Jaime Santos Pérez ,&nbsp;Mario Martínez-Galdámez ,&nbsp;Adrián Fernández García ,&nbsp;Herbert Daniel Jiménez Zapata","doi":"10.1016/j.neucir.2023.02.001","DOIUrl":"10.1016/j.neucir.2023.02.001","url":null,"abstract":"<div><h3>Introduction</h3><p>Spontaneous cerebrospinal fluid (CSF) fistula, of unknown origin, is a rare condition whose etiology is increasingly related to idiopathic intracranial hypertension (IIH). This study tries to raise awareness that they should not be considered as two different processes, but that fistulas can be a form of debut, requiring a study and subsequent treatment. Repair techniques are described, as well as the study of IIH.</p></div><div><h3>Results</h3><p>We treated eight patients, five women and three men, aged between 46 and 72 years, with a diagnosis of spontaneous CSF fistula, four nasal and four otics who underwent surgical treatment. After repair, a diagnostic study was performed for IIH by MRI and angio-MRI, presenting in all cases a transverse venous sinus stenosis. The intracranial pressure values obtained by lumbar puncture showed values of 20<!--> <!-->mmHg or higher. All patients were diagnosed with IIH. The one-year follow-up did not reveal any recurrence of the fistulas, maintaining a control of the IIH.</p></div><div><h3>Conclusion</h3><p>Despite their low frequency of both cranial CSF fistula and IIH, an association of both conditions should be considered by continuing the study and surveillance of these patients after fistula closure.</p></div>","PeriodicalId":51145,"journal":{"name":"Neurocirugia","volume":"35 2","pages":"Pages 57-63"},"PeriodicalIF":0.8,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129652285","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Short-term outcomes after selective shunt during carotid endarterectomy: A propensity score matching analysis 颈动脉内膜剥脱术中选择性分流术后的短期疗效:倾向评分匹配分析
IF 0.8 4区 医学 Q4 NEUROSCIENCES Pub Date : 2024-03-01 DOI: 10.1016/j.neucir.2023.07.006
Juliana Pereira-Macedo , Luís Afonso Fialho Duarte-Gamas , António Henrique Pereira-Neves , José Paulo Alves Vieira de Andrade , João Manuel Palmeira Rocha-Neves

Introduction and objectives

Carotid cross-clamping during carotid endarterectomy might lead to intraoperative neurologic deficits, increasing stroke/death risk. If deficits are detected, carotid shunting has been recommended to reduce the risk of stroke. However, shunting may sustain a specific chance of embolic events and subsequently incurring harm. Current evidence is still questionable regarding its clear benefit. The aim is to determine whether a policy of selective shunt impacts the complication rate following an endarterectomy.

Material and methods

From January 2013 to May 2021, all patients undergoing carotid endarterectomy under regional anesthesia with intraoperative neurologic alteration were retrieved. Patients submitted to selective shunt were compared to a non-shunt group. A 1:1 propensity score matching (PSM) was performed. Differences between the groups and clinical outcomes were calculated, resorting to univariate analysis.

Results

Ninety-eight patients were selected, from which 23 were operated on using a shunt. After PSM, 22 non-shunt patients were compared to 22 matched shunted patients. Concerning demographics and comorbidities, both groups were comparable to pre and post-PSM, except for chronic heart failure, which was more prevalent in shunted patients (26.1%, P = 0.036) in pre-PSM analysis. Regarding 30-day stroke and score Clavien–Dindo  2, no significant association was found (P = 0.730, P = 0.635 and P = 0.942, P = 0.472, correspondingly, for pre and post-PSM).

Conclusions

In this cohort, resorting to shunting did not demonstrate an advantage regarding 30-day stroke or a Clavien–Dindo  2 rates. Nevertheless, additional more extensive studies are mandatory to achieve precise results concerning the accurate utility of carotid shunting in this subset of patients under regional anesthesia.

导言和目的 颈动脉内膜剥脱术中的颈动脉交叉钳夹可能导致术中神经功能缺损,增加卒中/死亡风险。如果发现神经功能缺损,建议进行颈动脉分流以降低中风风险。然而,分流可能会维持栓塞事件的特定几率,进而造成伤害。目前的证据对分流的明显益处仍有疑问。材料和方法从 2013 年 1 月至 2021 年 5 月,检索了所有在区域麻醉下接受颈动脉内膜切除术且术中出现神经系统改变的患者。将接受选择性分流术的患者与未接受分流术的患者进行比较。进行了 1:1 倾向评分匹配(PSM)。通过单变量分析,计算了组间差异和临床结果。在 PSM 之后,22 名非分流患者与 22 名匹配的分流患者进行了比较。在人口统计学和合并症方面,两组患者在分流前和分流后的情况相当,但慢性心力衰竭除外,在分流前的分析中,分流患者的慢性心力衰竭发生率更高(26.1%,P = 0.036)。关于 30 天卒中和 Clavien-Dindo 评分≥ 2,未发现明显关联(P = 0.730、P = 0.635 和 P = 0.942、P = 0.472,PSM 前和 PSM 后相应)。尽管如此,还必须进行更多更广泛的研究,才能得出准确的结果,说明颈动脉分流术在区域麻醉下的这部分患者中的确切效用。
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引用次数: 0
Eficacia de las infiltraciones epidurales en el abordaje del dolor y la discapacidad por radiculopatía lumbosacra aguda y subaguda 硬膜外浸润治疗急性和亚急性腰骶椎根病引起的疼痛和残疾的疗效。
IF 0.8 4区 医学 Q4 NEUROSCIENCES Pub Date : 2024-03-01 DOI: 10.1016/j.neucir.2023.07.004
Jose Manuel Rabanal LLevot , Amaia Muñoz Alonso , Alberto Taborga Echevarría , Jose Angel Martínez Agueros , Sergio Maldonado Vega

Backgrund and objective

Epidural infiltrations are used for treatment of low back pain and sciatica. linked to lumbar radiculopathy (lumbosacral radicular syndrome). This study evaluates the efficacy of epidural infiltration by different routes to reduce pain intensity, disability and return to work.

Methods

Is a prospective observational study in one hundred consecutive patients sent to pain unit for severe lumbo-sacral radiculopaty. We analyze the efficacy on pain relief (Visual Analogue Scale) and funcional status at two weeks, one month, and three months after epidural injection of local anesthetics and esteroids with differents approachs (interlaminar, caudal and transforaminal).

Results

Ninety nine patients (46.5% men, 53.5 women) were finally enrrolled in the study. Mean age was 57.47 ± 11.1 years. The caudal approach was used in 58.6% patients, 23.2% transforaminal approach, and 18.2% interlaminar approach. A significant pain relief was found in all times studied (EAV 7.48 ± 1.5 basal; 6.2 ± 0,9 at 15 days; 6.3 ± 1.2 at one month; 6.15 ± 1.3 at 3 months, P<.05). Transforaminal approach was superior to caudal or interlaminal. Seventy percent in time off work patients returned to work after epidural inyections.

Conclusions

Epidural local anesthetics with esteroids injections for lumbo-sacral radiculopathy were effective for low back pain, improved functional status and promoted return to work. Transforaminal approach is superior to others.

背景和目的硬膜外浸润用于治疗与腰椎病(腰骶神经根综合征)相关的腰痛和坐骨神经痛。本研究评估了通过不同途径进行硬膜外浸润对减轻疼痛强度、减少残疾和重返工作岗位的疗效。方法这是一项前瞻性观察研究,研究对象是因严重腰骶部神经根病而被送往疼痛科的 100 名连续患者。我们分析了硬膜外注射局麻药和类固醇不同方法(椎间孔、尾骨和经椎间孔)后两周、一个月和三个月的疼痛缓解效果(视觉模拟量表)和功能状态。平均年龄为(57.47 ± 11.1)岁。58.6%的患者采用尾椎入路,23.2%采用经椎间孔入路,18.2%采用椎间孔入路。在所有研究时间内,疼痛均有明显缓解(基础 EAV 7.48 ± 1.5;15 天时 6.2 ± 0.9;1 个月时 6.3 ± 1.2;3 个月时 6.15 ± 1.3,P< .05)。经椎间孔入路优于尾椎或椎间孔入路。结论硬膜外局麻药联合类固醇注射治疗腰骶部神经根病对腰痛有效,可改善功能状态并促进重返工作岗位。经椎间孔方法优于其他方法。
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引用次数: 0
期刊
Neurocirugia
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