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Exclusionary data, inclusionary appeals: Gender and equity in an HIV-prevention clinical trial. 排除性数据,包容性申诉:艾滋病毒预防临床试验中的性别与公平。
IF 2.9 2区 社会学 Q1 HISTORY & PHILOSOPHY OF SCIENCE Pub Date : 2025-06-27 DOI: 10.1177/03063127251349231
Jason V D'Amours, Miranda R Waggoner

Despite the social and regulatory expectation that contemporary clinical trials for new pharmaceutical drugs will include a diverse set of research participants, achieving appropriate representation in clinical research remains tenuous. Of ongoing concern is how experts and regulators navigate decisions about drug approvals when presented with clinical studies that have limited demographic data. Drawing on regulatory discussions about Descovy, an HIV-prevention drug that was studied only in cisgender men and transgender women who have sex with men, we analyze a contentious debate over the meaning and impact of including and excluding certain populations from clinical trial design. Extending prior work in science and technology studies on how epistemological frameworks in clinical trials matter for concerns about the production of knowledge and social justice, we show how different conceptualizations of inclusion and equity (specifically, equity in data versus equity in access) come into tension in deliberations over pharmaceutical drug approvals. We argue that the discursive conflict over gender and inclusionary/exclusionary research practices that emerged in the case of Descovy points to an underappreciated feature of equity-temporality-that should be attended to when examining knowledge production in 21st-century clinical and regulatory landscapes.

尽管社会和监管机构期望新药的当代临床试验将包括不同的研究参与者,但在临床研究中实现适当的代表性仍然是脆弱的。目前令人担忧的是,专家和监管机构在面对人口统计数据有限的临床研究时,如何做出药物批准的决定。Descovy是一种hiv预防药物,仅在顺性男性和与男性发生性关系的跨性别女性中进行了研究,我们借鉴了关于Descovy的监管讨论,分析了在临床试验设计中包括或排除某些人群的意义和影响。在对临床试验中的认识论框架如何影响知识生产和社会正义的科学和技术研究进行扩展的基础上,我们展示了包容和公平的不同概念(具体而言,数据公平与获取公平)如何在药物批准的审议中产生紧张关系。我们认为,在Descovy案例中出现的关于性别和包容性/排他性研究实践的话语冲突,指出了公平的一个未被充分认识的特征——时间性——在检查21世纪临床和监管领域的知识生产时,应该注意到这一点。
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引用次数: 0
The extractive loops of biocapital: Venom procurement and antivenom production in India. 生物资本的提取循环:印度的蛇毒采购和抗蛇毒血清生产。
IF 3 2区 社会学 Q1 HISTORY & PHILOSOPHY OF SCIENCE Pub Date : 2025-06-20 DOI: 10.1177/03063127251347915
Mathieu Quet
A growing body of research and scholarship has examined the exploitation of animals by the biopharmaceutical industry, framing it variously in terms of labour, commodification, or hybrid processes. This article adds to the discussion through an ethnography of antivenom manufacturing in India. It introduces the concept of 'extractive loops' embedding species, locations, and work practices. Extractive loops form a continuum through which non-human life contributes to the manufacturing of resources (raw materials and finished products). The argument relies on a description of the operations required by the production of antivenom, involving: (a) several animal species (mostly snakes, horses, and rodents), (b) connections between a multiplicity of locations, from outdoor fields to industrial sites, (c) a wide range of professional practices, some of them strictly formalized whereas others are mainly informal (such as snake catching), and (d) heterogeneous exploitation of non-human life and products. Extractive loops highlight a key feature of animal exploitation: a recurring series of extractive practices contributing to the continuous fabrication of natural resources.
越来越多的研究和学术机构研究了生物制药行业对动物的剥削,从劳动力、商品化或混合过程的角度对其进行了不同的界定。这篇文章通过印度抗蛇毒血清制造的民族志增加了讨论。它引入了嵌入物种、地点和工作实践的“提取循环”概念。提取循环形成一个连续体,非人类生命通过这个连续体为资源(原材料和成品)的制造做出贡献。该论点依赖于对生产抗蛇毒血清所需操作的描述,涉及:(a)几种动物物种(主要是蛇、马和啮齿动物),(b)从户外田野到工业场所等多个地点之间的联系,(c)广泛的专业实践,其中一些是严格正式的,而另一些则主要是非正式的(如捕蛇),以及(d)对非人类生命和产品的异质开发。采掘循环强调了动物剥削的一个关键特征:一系列重复的采掘行为促进了自然资源的不断制造。
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引用次数: 0
Handmade relief models as matters of concern: Maintaining, restoring, and repairing mountains? 手工浮雕模型值得关注:维护、修复、修复山脉?
IF 3 2区 社会学 Q1 HISTORY & PHILOSOPHY OF SCIENCE Pub Date : 2025-06-14 DOI: 10.1177/03063127251346168
Alain Müller
Through a case study of what are known as ‘relief models’—for example of areas of landscapes—this article approaches representational objects in and as practice. Such an approach implies following the multiplicity of practices that are gathered in representational objects to bring them into and maintain their existence, especially those that often remain unacknowledged by analytical attention. Most discussions of representational objects focus on their representational capacities and properties, paying less attention to the activities that ensure their ontological security as objects. Those activities concern not only the manufacture of representational objects, but also their maintenance—which is placed at the heart of this discussion. The maintenance of relief models manifests itself as a semiotic-material ecology. Entangled here are the ontological tact of the craftsperson, the affordances, resistances, and responsiveness of the materials, and the meaning-makings and stories that articulate and guide maintenance and repair. The practice of maintaining such objects, however, diverges from their production. Their production essentially accommodates metric distance since representation involves transporting a ‘thing’ through chains of reference. On the contrary, their maintenance aims to accommodate multiple temporalities. This involves not only the ways of being in time that are specific to each material that composes the object but also the idealized past of an unused object, its worn present, and its anticipated (repaired) future. By playing with the double meaning of the word ‘representing’, this article speculatively questions the extent to which practices of maintenance of, and care for, representational objects can inform a re-vision and rethinking of the relationships to what they are meant to re-present —that is, to what counts as nature.
通过一个被称为“浮雕模型”的案例研究——例如景观区域——本文在实践中接近具象对象。这种方法意味着遵循在具象对象中收集的多种实践,以使它们进入并保持它们的存在,特别是那些通常未被分析性关注所承认的实践。大多数关于表征对象的讨论都集中在它们的表征能力和属性上,而很少关注确保它们作为对象的本体论安全的活动。这些活动不仅涉及具象对象的制造,还涉及它们的维护——这是本次讨论的核心。浮雕模型的维护表现为一种符号-物质生态。纠缠在这里的是工匠的本体论,材料的支持、抵抗和响应,以及表达和指导维护和修复的意义制造和故事。然而,维护这些物品的实践与它们的生产是不同的。它们的产生本质上适应了度量距离,因为表征涉及到通过参考链传递“事物”。相反,它们的维护旨在适应多种暂时性。这不仅涉及到构成物体的每种材料的特定时间方式,还涉及到未使用物体的理想化过去、磨损的现在和预期(修复)的未来。通过玩弄“表征”一词的双重含义,本文思辨性地质疑,维护和照顾表征对象的实践在多大程度上可以告知重新审视和重新思考与它们所要表征的关系-也就是说,什么被视为自然。
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引用次数: 0
Precision justice: An imaginary of data and justice 精确正义:数据和正义的想象
IF 3 2区 社会学 Q1 HISTORY & PHILOSOPHY OF SCIENCE Pub Date : 2025-06-14 DOI: 10.1177/03063127251342275
Margarita Boenig-Liptsin
In Aldous Huxley’s 1932 novel Brave New World every person is conditioned through technologies to fit their social role, which is the source of the society’s alleged stability and rightness. This utopia of ‘precision justice’ is alive today in projects that deploy data and algorithmic models in decision-making in diverse branches of life to realize computing’s promise to create more just societies. I identify the sociotechnical imaginary of ‘precision justice’ by analyzing the promise and contestation of the use of an algorithmic model to calculate exam grades in the United Kingdom during the Covid-19 pandemic. ‘Precision justice’ is the product of the coupling of a normative concept of just distribution with data practices of identification and risk assessment, and is characterized by interventionist action, optimal distribution, and system management. It crystallized in the contexts of the emerging ‘information society’ in the 1970s United States, when visions of the risks and opportunities of information in digital form converged with the popular theory and practices of distributive justice. At stake in this imaginary is the model of the human with which it operates and that it reproduces. Instead of keying people to a substantive and expansive concept of justice, the union of distributive justice and data practices bind people to indicators and allocate them to specific places in society. To move beyond precision justice, this article calls for the need to look at justice and data symmetrically, as a simultaneously epistemic and normative set of concerns that must be addressed together in terms of what worlds we want to build.
在赫胥黎(Aldous Huxley) 1932年的小说《美丽新世界》(Brave New World)中,每个人都被技术制约着,以适应他们的社会角色,这是社会所谓稳定和正确的来源。这种“精确正义”的乌托邦在今天的项目中仍然存在,这些项目将数据和算法模型部署到生活的各个分支的决策中,以实现计算创造更公正社会的承诺。我通过分析2019冠状病毒病大流行期间英国使用算法模型计算考试成绩的前景和争议,确定了“精确正义”的社会技术想象。“精确正义”是公正分配的规范概念与识别和风险评估的数据实践相结合的产物,其特点是干预行动、最佳分配和系统管理。它在20世纪70年代美国新兴的“信息社会”背景下具体化,当时对数字形式信息的风险和机会的看法与流行的分配正义理论和实践融合在一起。在这一想象中,关键是人类的模型,它用它来运作和繁殖。分配正义和数据实践的结合并没有将人们引向实质性和宽泛的正义概念,而是将人们与指标捆绑在一起,并将其分配到社会的特定位置。为了超越精确的正义,本文呼吁需要对称地看待正义和数据,作为一组同时存在的认知和规范问题,必须根据我们想要构建的世界一起解决。
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引用次数: 0
Self-tracking in endometriosis: Evolving expectations around a gynecological app developed by a Finnish patient organization 子宫内膜异位症的自我跟踪:芬兰患者组织开发的妇科应用程序的演变期望
IF 3 2区 社会学 Q1 HISTORY & PHILOSOPHY OF SCIENCE Pub Date : 2025-06-14 DOI: 10.1177/03063127251344961
Venla Oikkonen, Maria Temmes
The article examines the possibilities and limits of patient advocacy-led health technology design through a case study: a non-commercial mobile self-tracking app developed by a Finnish patient organization to advance medical care and research in endometriosis, an underfunded and understudied gynecological condition. Drawing on interviews with patient organization representatives, specialized clinicians and people with endometriosis, as well as written endometriosis stories, this article traces the evolving expectations around the app to understand the landscape of hopes and concerns in which patient advocacy-led design is conceived and received. This article identifies tensions in visions about how the app could be used as well as locates shifts in expectations as the app moved from an idea to everyday use. The article also shows how structural aspects of established technological systems, such as digital health infrastructures or data ownership relations, shape expectations about future uses of patient advocacy-led technology. This case study contributes to science and technology studies scholarship on self-tracking and health technology development by providing a nuanced understanding of how the dynamics of expectation in patient advocacy-led design operate in a complex and underdiagnosed gendered chronic illness.
本文通过一个案例研究,探讨了以患者倡导为主导的健康技术设计的可能性和局限性:一个由芬兰患者组织开发的非商业移动自我跟踪应用程序,用于推进子宫内膜异位症的医疗保健和研究,子宫内膜异位症是一种资金不足且研究不足的妇科疾病。通过对患者组织代表、专业临床医生和子宫内膜异位症患者的采访,以及撰写的子宫内膜异位症故事,本文追溯了围绕该应用程序不断变化的期望,以了解患者倡导主导的设计构思和接受的希望和担忧的前景。这篇文章指出了关于如何使用这款应用的矛盾,以及当应用从一个想法变成日常使用时,人们对它的期望发生了变化。本文还展示了已建立的技术系统的结构方面,如数字卫生基础设施或数据所有权关系,如何影响对未来使用以患者倡导为主导的技术的期望。本案例研究为自我跟踪和健康技术发展的科学和技术研究奖学金提供了细致入微的理解,了解患者倡导主导的设计中期望的动态如何在复杂且诊断不足的性别慢性疾病中运作。
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引用次数: 0
Response to Damianos—Anthropocene angst: Authentic geology and stratigraphic sincerity 对达米亚诺斯-人类世焦虑的回应:真实的地质学和地层学诚意
IF 3 2区 社会学 Q1 HISTORY & PHILOSOPHY OF SCIENCE Pub Date : 2025-06-09 DOI: 10.1177/03063127251343046
Colin N Waters, Jan Zalasiewicz, Martin J Head, Georg N Schäfer, Francine MG McCarthy, Simon D Turner
Damianos provides his views on the significance of the March 2024 decision by the International Commission on Stratigraphy (ICS) to reject the proposal of the Anthropocene Working Group (AWG), the body we represent, to formalize the Anthropocene as a series/epoch of the Geological Time Scale. He draws upon ‘four years of ethnographic observation’ of the AWG, over which time this body provided him with access to its meetings and discussions. Given this access, the numerous misrepresentations within his article warrant redress. Ultimately, his conclusions mimic claims of influential figures within the governing bodies of the stratigraphic process: that the AWG were attempting to formalize the Anthropocene for political reasons and subvert the process through use of the media, and that the proposed definition was based upon claims about the future and not the past geological record. We refute those accusations, and emphasize that the proposed Anthropocene epoch, based on scrupulous and detailed analysis of the stratigraphic record, demonstrates striking and transformative Earth System change driven by the mid-20th century ‘Great Acceleration’ of human activities.
Damianos提供了他对国际地层学委员会(ICS)在2024年3月决定的重要性的看法,该决定拒绝了人类世工作组(AWG)的建议,即我们所代表的机构,将人类世正式确定为地质时间尺度的一系列/时代。他利用了对AWG“四年的人种学观察”,在此期间,这个机构为他提供了参加会议和讨论的机会。鉴于这一途径,他文章中的许多错误陈述值得纠正。最后,他的结论模仿了地层学过程管理机构中有影响力的人物的说法:AWG试图出于政治原因将人类世正式化,并利用媒体颠覆这一过程,而且提议的定义是基于对未来的主张,而不是基于过去的地质记录。我们驳斥了这些指控,并强调提出的人类世时代是基于对地层记录的细致分析,证明了20世纪中期人类活动的“大加速”推动了地球系统的显著变化。
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引用次数: 0
First impressions matter: Mundane obstacles to a forensic device for probabilistic reporting in fingerprint analysis. 第一印象很重要:在指纹分析中进行概率报告的法医设备面临的世俗障碍。
IF 3 2区 社会学 Q1 HISTORY & PHILOSOPHY OF SCIENCE Pub Date : 2025-05-07 DOI: 10.1177/03063127251333074
Simon A Cole,Justin L Sola
This article investigates why statistical reasoning has had little impact on the practice of friction ridge (or 'fingerprint') examination, despite both interest and some modest scientific progress toward this goal. Previous research has attributed this lack of results to practitioner resistance and legal apathy. This article seeks to complement those explanations through interviews with experts with a variety of perspectives on contemporary fingerprint practice about practical and mundane obstacles to the belated statistical revolution in fingerprinting. Based on these interviews, we argue that a 'forensic device' is required to incorporate statistical reasoning into fingerprint practice. This device would consist of a robust statistical model fronted by accessible, usable software. These components, in turn, require other components, such as large research data sets, markets, early adopters, government clients, education, and training. We conclude that the statistical revolution has been delayed not just by grand debates over the probabilistic nature of fingerprint evidence, but also by the seemingly mundane problems posed by developing and maintaining the kind of forensic device that would make such a revolution possible and practical.
本文调查了为什么统计推理对摩擦脊(或“指纹”)检查的实践几乎没有影响,尽管对这一目标既有兴趣,也有一些适度的科学进展。先前的研究将这种缺乏结果归因于从业者的抵制和法律冷漠。本文试图通过对专家的采访来补充这些解释,这些专家对当代指纹实践的各种观点,关于指纹识别中迟来的统计革命的实际和世俗障碍。基于这些访谈,我们认为需要一种“法医设备”来将统计推理纳入指纹实践。该设备将由一个健壮的统计模型组成,前端是可访问的、可用的软件。这些组成部分反过来又需要其他组成部分,如大型研究数据集、市场、早期采用者、政府客户、教育和培训。我们得出的结论是,统计革命之所以被推迟,不仅是因为对指纹证据的概率性进行了激烈的辩论,而且还因为开发和维护一种法医设备所带来的看似平凡的问题,而这种设备将使这种革命成为可能和实用。
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引用次数: 0
Making a show of it: Reading demonstrations of empty government innovation through the metaphor of façade. 作秀:通过faalade的比喻解读政府空洞创新的例证。
IF 3 2区 社会学 Q1 HISTORY & PHILOSOPHY OF SCIENCE Pub Date : 2025-05-06 DOI: 10.1177/03063127251337781
Santtu Räisänen
This article examines meaning-making in a governmental technology demonstration, and its significance in the production of a durable artifice of innovation. STS literature has largely engaged with technology demonstrations in the context of commercial technology products, and through the lens of public knowledge-making: as events that elicit credence in matters-of-fact. I contribute to this discussion by turning attention towards a new context, governmental innovation, and approaching the format, not through its epistemics, but rather its aesthetic and affective registers. Over the course of a project aimed at building a governmental software system called the AuroraAI Network, to be used for the empowerment of welfare subjects, the Department of Government ICT at the Finnish Ministry of Finance produced a series of four highly theatrical events that sought to demonstrate the development of the AI system. Using social-semiotic performance analysis, I analyse these events as a kind of façade, one that presents the trappings of technology demonstration, but rather than advancing specific technical matters-of-fact, produces an affective and aesthetic sensibility of government innovation. By mobilizing the metaphor of façade, this research shows how empty innovation is made durable and successful.
本文考察了政府技术示范中的意义建构,以及它对持久创新机制产生的意义。STS文献主要涉及商业技术产品背景下的技术演示,并通过公共知识制造的镜头:作为引发对事实的信任的事件。我将注意力转向一个新的背景,即政府创新,并通过其美学和情感注册而不是认识论来接近格式,从而促成了这一讨论。在一个旨在建立一个名为AuroraAI网络的政府软件系统的项目过程中,用于赋予福利主体权力,芬兰财政部政府信息通信技术部制作了一系列四个高度戏剧性的活动,试图展示人工智能系统的发展。使用社会符号学绩效分析,我将这些事件分析为一种假象,一种呈现技术演示的陷阱,但不是推进具体的技术事实,而是产生对政府创新的情感和审美敏感性。本研究以“虚荣心”为隐喻,揭示了“虚荣心”创新是如何得以持久和成功的。
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引用次数: 0
Virtual diversity: A proposal and discussion 虚拟多样性:一个建议和讨论
IF 3 2区 社会学 Q1 HISTORY & PHILOSOPHY OF SCIENCE Pub Date : 2025-04-11 DOI: 10.1177/03063127251334495
Sergio Sismondo
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引用次数: 0
Virtual diversity revisited 重新审视虚拟多样性
IF 3 2区 社会学 Q1 HISTORY & PHILOSOPHY OF SCIENCE Pub Date : 2025-04-11 DOI: 10.1177/03063127251330545
Harry Collins, Robert Evans, Luis Reyes-Galindo
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引用次数: 0
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Social Studies of Science
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