{"title":"Gender inequalities in inflammatory dermatoses and an unmet need for enhanced management in the Indian context","authors":"A. Bishnoi, Smriti Gupta, H. Mehta, K. Vinay","doi":"10.25259/ijdvl_130_2024","DOIUrl":"https://doi.org/10.25259/ijdvl_130_2024","url":null,"abstract":"","PeriodicalId":513160,"journal":{"name":"Indian Journal of Dermatology, Venereology and Leprology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141805517","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Granuloma annulare (GA) is a necrobiotic granulomatous disorder that may sometimes be resistant to treatment, especially the generalised form. Tofacitinib has recently shown promise in the treatment of non-infective granulomatous dermatosis. In this study, we aimed to evaluate the response of generalised GA to oral tofacitinib. This was a retrospective case series in patients of generalised GA who were treated with oral tofacitinib 5 mg twice a day in a tertiary care centre in north India. Baseline clinical details and histopathological findings were reviewed. Treatment response was noted in the form of clearance of lesions (complete or partial) along with the time taken to achieve the maximum response. A total of 15 patients of generalised GA were included in this study, amongst whom nine patients were resistant to conventional therapies whilst the remaining were treatment naïve. Complete clearance of lesions was noted in 11 patients at a mean treatment duration of 4.4 ± 2.1 months whereas clearance was partial in four, with a mean follow-up duration post- treatment in patients who had partial clearance, which is 7.3 ± 2.8 month, with a reduction in erythema and infiltration in those lesions. Adverse effects in the form of hyperlipidemia were observed in two patients. Tofacitinib, a JAK-STAT inhibitor is beneficial in treating GA, especially in those with generalised and recalcitrant disease.
环状肉芽肿（GA）是一种坏死性肉芽肿性疾病，有时可能对治疗产生耐药性，尤其是泛发性GA。在这项研究中，我们旨在评估泛发性环形肉芽肿对口服托法替尼的反应。这是一项回顾性病例系列研究，研究对象是在印度北部一家三级医疗中心接受口服托法替尼治疗的泛发性环形肉芽肿患者，每次5毫克，每天两次。对基线临床细节和组织病理学结果进行了回顾。本研究共纳入了 15 例全身性 GA 患者，其中 9 例患者对常规疗法产生耐药性，其余患者为治疗新手。11名患者的皮损完全清除，平均治疗时间为（4.4±2.1）个月，4名患者的皮损部分清除，部分清除的患者治疗后的平均随访时间为（7.3±2.8）个月，这些皮损的红斑和浸润有所减轻。托法替尼是一种JAK-STAT抑制剂，可用于治疗GA，尤其是全身性和顽固性GA。
{"title":"Therapeutic success of tofacitinib in granuloma annulare: A retrospective case series of 15 patients","authors":"A. Dev, V. Keshavamurthy, Debajyoti Chatterjee","doi":"10.25259/ijdvl_215_2024","DOIUrl":"https://doi.org/10.25259/ijdvl_215_2024","url":null,"abstract":"\u0000\u0000Granuloma annulare (GA) is a necrobiotic granulomatous disorder that may sometimes be resistant to treatment, especially the generalised form. Tofacitinib has recently shown promise in the treatment of non-infective granulomatous dermatosis.\u0000\u0000\u0000\u0000In this study, we aimed to evaluate the response of generalised GA to oral tofacitinib.\u0000\u0000\u0000\u0000This was a retrospective case series in patients of generalised GA who were treated with oral tofacitinib 5 mg twice a day in a tertiary care centre in north India. Baseline clinical details and histopathological findings were reviewed. Treatment response was noted in the form of clearance of lesions (complete or partial) along with the time taken to achieve the maximum response.\u0000\u0000\u0000\u0000A total of 15 patients of generalised GA were included in this study, amongst whom nine patients were resistant to conventional therapies whilst the remaining were treatment naïve. Complete clearance of lesions was noted in 11 patients at a mean treatment duration of 4.4 ± 2.1 months whereas clearance was partial in four, with a mean follow-up duration post- treatment in patients who had partial clearance, which is 7.3 ± 2.8 month, with a reduction in erythema and infiltration in those lesions. Adverse effects in the form of hyperlipidemia were observed in two patients.\u0000\u0000\u0000\u0000Tofacitinib, a JAK-STAT inhibitor is beneficial in treating GA, especially in those with generalised and recalcitrant disease.\u0000","PeriodicalId":513160,"journal":{"name":"Indian Journal of Dermatology, Venereology and Leprology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141819408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-20DOI: 10.25259/ijdvl_1316_2023
S. Pai, K. Pai, Anuradha Calicut Kini Rao, SV Bharath
{"title":"Obesity-associated lymphedematous mucinosis in two patients: An emerging lifestyle disease","authors":"S. Pai, K. Pai, Anuradha Calicut Kini Rao, SV Bharath","doi":"10.25259/ijdvl_1316_2023","DOIUrl":"https://doi.org/10.25259/ijdvl_1316_2023","url":null,"abstract":"","PeriodicalId":513160,"journal":{"name":"Indian Journal of Dermatology, Venereology and Leprology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141819787","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ritu Mittal, Ankita Tuknayat, Nidhi Singla, R. Bhagat, M. Bhalla
{"title":"Topical liposomal amphotericin B with surgical debridement in primary cutaneous mucormycosis","authors":"Ritu Mittal, Ankita Tuknayat, Nidhi Singla, R. Bhagat, M. Bhalla","doi":"10.25259/ijdvl_401_2024","DOIUrl":"https://doi.org/10.25259/ijdvl_401_2024","url":null,"abstract":"","PeriodicalId":513160,"journal":{"name":"Indian Journal of Dermatology, Venereology and Leprology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141820312","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Transient pigmentary lines of the newborn","authors":"Murat Ozturk, Sadeddin Coskun","doi":"10.25259/ijdvl_464_2024","DOIUrl":"https://doi.org/10.25259/ijdvl_464_2024","url":null,"abstract":"","PeriodicalId":513160,"journal":{"name":"Indian Journal of Dermatology, Venereology and Leprology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141823606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Terry’s nails","authors":"Akriti Agrawal, R. Beniwal","doi":"10.25259/ijdvl_232_2024","DOIUrl":"https://doi.org/10.25259/ijdvl_232_2024","url":null,"abstract":"","PeriodicalId":513160,"journal":{"name":"Indian Journal of Dermatology, Venereology and Leprology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141822049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Shreya K Gowda, Sonika Garg, Anusha Khajjayam, S. Sahu, Maninder Kaur, S. Patra, B. Behera, Vishal Thakur
{"title":"Superior mesenteric artery syndrome – An unusual presentation associated with diffuse cutaneous systemic sclerosis in two cases","authors":"Shreya K Gowda, Sonika Garg, Anusha Khajjayam, S. Sahu, Maninder Kaur, S. Patra, B. Behera, Vishal Thakur","doi":"10.25259/ijdvl_315_2024","DOIUrl":"https://doi.org/10.25259/ijdvl_315_2024","url":null,"abstract":"","PeriodicalId":513160,"journal":{"name":"Indian Journal of Dermatology, Venereology and Leprology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141822057","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-19DOI: 10.25259/ijdvl_1252_2023
C. Avcı, Gülfem Akın, Ayca Aydogan, S. Akarsu, T. Ilknur, Ş. Aktan
{"title":"Rituximab in the treatment of severe childhood pemphigus vulgaris accompanying phenylketonuria: A case report","authors":"C. Avcı, Gülfem Akın, Ayca Aydogan, S. Akarsu, T. Ilknur, Ş. Aktan","doi":"10.25259/ijdvl_1252_2023","DOIUrl":"https://doi.org/10.25259/ijdvl_1252_2023","url":null,"abstract":"","PeriodicalId":513160,"journal":{"name":"Indian Journal of Dermatology, Venereology and Leprology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141821613","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Donna C Philip Tharappel, Sumedha Ballal, I. Y. Kalegowda
{"title":"Histopathologic study of morphea","authors":"Donna C Philip Tharappel, Sumedha Ballal, I. Y. Kalegowda","doi":"10.25259/ijdvl_316_2024","DOIUrl":"https://doi.org/10.25259/ijdvl_316_2024","url":null,"abstract":"","PeriodicalId":513160,"journal":{"name":"Indian Journal of Dermatology, Venereology and Leprology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141821387","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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