Pub Date : 2024-07-04DOI: 10.25259/ijdvl_1059_2023
Jiali Xia, Huimin Tang, Guan Jiang
Odontogenic cutaneous fistulas (OCST) are pathological connections between the facial skin and oral cavity caused by chronic dental infection. They are often misdiagnosed or underdiagnosed by dermatologists. This study explores the clinical and radiographic features of patients with odontogenic cutaneous fistulas. This study retrospectively analysed the clinical data of 60 patients diagnosed with odontogenic cutaneous fistulas between January 2016 and February 2022. The study identified a predominance of OCST in males (53.3%) with a mean age of 49 years. There was a significant difference in the distribution between the maxillary and mandibular zones [(14/60, 23.3%) vs (46/60, 76.7%), p < 0.001]. Nodules are the most frequent morphology (48.3%). Imaging findings included periapical radiolucency, bone erosion and the presence of a sinus tract. All patients responded well to dental treatments with no recurrences noted. This is a retrospective study design and has a limited number of patients. Collaborative efforts between dentists and dermatologists are crucial for accurate diagnosis and treatment, enhancing patient outcomes.
{"title":"A retrospective study of the clinical and imaging features of 60 cases of odontogenic cutaneous fistula","authors":"Jiali Xia, Huimin Tang, Guan Jiang","doi":"10.25259/ijdvl_1059_2023","DOIUrl":"https://doi.org/10.25259/ijdvl_1059_2023","url":null,"abstract":"\u0000\u0000Odontogenic cutaneous fistulas (OCST) are pathological connections between the facial skin and oral cavity caused by chronic dental infection. They are often misdiagnosed or underdiagnosed by dermatologists.\u0000\u0000\u0000\u0000This study explores the clinical and radiographic features of patients with odontogenic cutaneous fistulas.\u0000\u0000\u0000\u0000This study retrospectively analysed the clinical data of 60 patients diagnosed with odontogenic cutaneous fistulas between January 2016 and February 2022.\u0000\u0000\u0000\u0000The study identified a predominance of OCST in males (53.3%) with a mean age of 49 years. There was a significant difference in the distribution between the maxillary and mandibular zones [(14/60, 23.3%) vs (46/60, 76.7%), p < 0.001]. Nodules are the most frequent morphology (48.3%). Imaging findings included periapical radiolucency, bone erosion and the presence of a sinus tract. All patients responded well to dental treatments with no recurrences noted.\u0000\u0000\u0000\u0000This is a retrospective study design and has a limited number of patients.\u0000\u0000\u0000\u0000Collaborative efforts between dentists and dermatologists are crucial for accurate diagnosis and treatment, enhancing patient outcomes.\u0000","PeriodicalId":513160,"journal":{"name":"Indian Journal of Dermatology, Venereology and Leprology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141678642","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-04DOI: 10.25259/ijdvl_1145_2023
Swapnil Shah, S. Hegde
{"title":"Lingua villosa nigra in an infant","authors":"Swapnil Shah, S. Hegde","doi":"10.25259/ijdvl_1145_2023","DOIUrl":"https://doi.org/10.25259/ijdvl_1145_2023","url":null,"abstract":"","PeriodicalId":513160,"journal":{"name":"Indian Journal of Dermatology, Venereology and Leprology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141679651","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Leprosy is no longer considered an imprecation, as an effective multidrug therapy regimen is available worldwide for its cure. However, its diverse clinical manifestations sometimes involve acute inflammatory reactions. These complications result in irreversible nerve damage, neuritis and anatomical deformities that emerge before, during the treatment or after the completion of treatment. Reversal reaction (Type-I) and erythema nodosum leprosum (Type-II) are the leprosy reactions generally seen in patients with lepromatous and borderline forms of leprosy. At present, there is no accurate diagnostic test available to detect these leprosy reactions. To identify potential biomarkers indicative of Type-I and Type-II leprosy reactions that could help in their early diagnosis. Host-transcriptomics investigations have been utilised in this study to decipher a correlation between host-gene expression-based biomarkers and exacerbation of leprosy reactions. We present a comparative analysis of publicly available host transcriptomics datasets (from Gene Expression Omnibus) related to leprosy reactions. Individual datasets were analysed and integration of results was carried out using meta-analysis. Common differentially expressed genes (DEGs) were identified using the frequentist and Bayesian ratio association test methods. We have identified several genes – ADAMTS5, ADAMTS9, IFITM2, IFITM3, KIRREL, ANK3, CD1E, CTSF, DOCK9 and KRT73 to name a few – which can serve as potential biomarkers for Type-II reaction. Similarly, ACP5, APOC1, CCL17, S100B, SLC11A1 among others may likely serve as biomarkers for Type-I reaction. The number of datasets related to leprosy reactions found after the systematic search is less (n = 4) and may limit the accuracy of identified biomarker genes. This could be resolved by including more studies in the data analysis. We provide a comprehensive list of gene candidates which could be prioritised further in research focusing on immune reactions in leprosy, as they are likely important in understanding its complexities and could be useful in its early diagnosis.
麻风病不再被认为是一种蔑称，因为全世界都有有效的多种药物治疗方案来治愈麻风病。然而，麻风病的临床表现多种多样，有时会出现急性炎症反应。这些并发症会导致不可逆转的神经损伤、神经炎和解剖学畸形，在治疗前、治疗过程中或治疗结束后都会出现。逆转反应（I 型）和结节性麻风红斑（II 型）是麻风病人和边缘型麻风病人通常会出现的麻风反应。本研究利用宿主转录组学调查来破译基于宿主基因表达的生物标志物与麻风反应加重之间的相关性。我们对与麻风病反应有关的公开宿主转录组学数据集（来自基因表达总库）进行了比较分析。我们对单个数据集进行了分析，并通过荟萃分析对结果进行了整合。使用频数法和贝叶斯比值关联检验法确定了常见的差异表达基因（DEGs）。我们确定了几个基因--ADAMTS5、ADAMTS9、IFITM2、IFITM3、KIRREL、ANK3、CD1E、CTSF、DOCK9 和 KRT73 等等--可作为 II 型反应的潜在生物标记物。同样，ACP5、APOC1、CCL17、S100B、SLC11A1等也可能成为I型反应的生物标志物。系统搜索后发现的与麻风反应相关的数据集数量较少（n = 4），这可能会限制已确定的生物标志基因的准确性。我们提供了一份全面的候选基因列表，在以麻风病免疫反应为重点的研究中可进一步优先考虑这些基因，因为它们可能对了解麻风病的复杂性非常重要，并有助于麻风病的早期诊断。
{"title":"Comparative host transcriptomics as a tool to identify candidate biomarkers for immune reactions in leprosy using meta-analysis","authors":"Anuj Mavlankar, Mukul Sharma, Afzal Ansari, Pushpendra Singh","doi":"10.25259/ijdvl_532_2022","DOIUrl":"https://doi.org/10.25259/ijdvl_532_2022","url":null,"abstract":"\u0000\u0000Leprosy is no longer considered an imprecation, as an effective multidrug therapy regimen is available worldwide for its cure. However, its diverse clinical manifestations sometimes involve acute inflammatory reactions. These complications result in irreversible nerve damage, neuritis and anatomical deformities that emerge before, during the treatment or after the completion of treatment. Reversal reaction (Type-I) and erythema nodosum leprosum (Type-II) are the leprosy reactions generally seen in patients with lepromatous and borderline forms of leprosy. At present, there is no accurate diagnostic test available to detect these leprosy reactions.\u0000\u0000\u0000\u0000To identify potential biomarkers indicative of Type-I and Type-II leprosy reactions that could help in their early diagnosis.\u0000\u0000\u0000\u0000Host-transcriptomics investigations have been utilised in this study to decipher a correlation between host-gene expression-based biomarkers and exacerbation of leprosy reactions. We present a comparative analysis of publicly available host transcriptomics datasets (from Gene Expression Omnibus) related to leprosy reactions. Individual datasets were analysed and integration of results was carried out using meta-analysis. Common differentially expressed genes (DEGs) were identified using the frequentist and Bayesian ratio association test methods. We have identified several genes – ADAMTS5, ADAMTS9, IFITM2, IFITM3, KIRREL, ANK3, CD1E, CTSF, DOCK9 and KRT73 to name a few – which can serve as potential biomarkers for Type-II reaction. Similarly, ACP5, APOC1, CCL17, S100B, SLC11A1 among others may likely serve as biomarkers for Type-I reaction.\u0000\u0000\u0000\u0000The number of datasets related to leprosy reactions found after the systematic search is less (n = 4) and may limit the accuracy of identified biomarker genes. This could be resolved by including more studies in the data analysis.\u0000\u0000\u0000\u0000We provide a comprehensive list of gene candidates which could be prioritised further in research focusing on immune reactions in leprosy, as they are likely important in understanding its complexities and could be useful in its early diagnosis.\u0000","PeriodicalId":513160,"journal":{"name":"Indian Journal of Dermatology, Venereology and Leprology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141677220","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-04DOI: 10.25259/ijdvl_1281_2023
S. Neema, S. R. Choudhary, M. Madakshira
{"title":"Slow growing lesion on face","authors":"S. Neema, S. R. Choudhary, M. Madakshira","doi":"10.25259/ijdvl_1281_2023","DOIUrl":"https://doi.org/10.25259/ijdvl_1281_2023","url":null,"abstract":"","PeriodicalId":513160,"journal":{"name":"Indian Journal of Dermatology, Venereology and Leprology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141679188","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-04DOI: 10.25259/ijdvl_1177_2023
Ritu Gujarati Vishwanath
{"title":"An uncommon presentation of a common disease – Pure neural Hansen’s disease with sinus on skin","authors":"Ritu Gujarati Vishwanath","doi":"10.25259/ijdvl_1177_2023","DOIUrl":"https://doi.org/10.25259/ijdvl_1177_2023","url":null,"abstract":"","PeriodicalId":513160,"journal":{"name":"Indian Journal of Dermatology, Venereology and Leprology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141679477","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Shikha Shah, Rahul Mahajan, K. Ajithkumar, Sunil Dogra
{"title":"Letter to the editor regarding Association between asthma, rhinitis and atopic dermatitis with leprosy: A case-control study","authors":"Shikha Shah, Rahul Mahajan, K. Ajithkumar, Sunil Dogra","doi":"10.25259/ijdvl_507_2024","DOIUrl":"https://doi.org/10.25259/ijdvl_507_2024","url":null,"abstract":"","PeriodicalId":513160,"journal":{"name":"Indian Journal of Dermatology, Venereology and Leprology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141683292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Modified acne scar revision - Punch excision, punch-in-subcision with shoulder dermabrasion followed by dermal grafting","authors":"Sushil S. Savant Jr","doi":"10.25259/ijdvl_914_2023","DOIUrl":"https://doi.org/10.25259/ijdvl_914_2023","url":null,"abstract":"","PeriodicalId":513160,"journal":{"name":"Indian Journal of Dermatology, Venereology and Leprology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141682585","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-03DOI: 10.25259/ijdvl_1322_2023
Abhishek Lachyan, N. Khunger, Pragyan Swagatika Panda
Bacterial vaginosis (BV), characterised by an imbalance in vaginal microbiota, frequently leading to recurrent episodes, has garnered recent research attention due to the significance of biofilms in its pathogenesis. BV biofilms contribute to recurrence by providing a shelter for harmful bacteria, rendering them resistant to conventional treatment. Objectives of this review include characterising BV biofilms, evaluating the limitations of current antibiotic therapy, highlighting emerging solutions and emphasising multifaceted approaches. The review presents data from clinical studies and trials on biofilm-focused treatments which might reduce BV recurrence, with the ultimate goal of improving the quality of life of women with BV and reducing its burden on their reproductive health.
{"title":"Bacterial vaginosis and biofilms: Therapeutic challenges and innovations – A narrative review","authors":"Abhishek Lachyan, N. Khunger, Pragyan Swagatika Panda","doi":"10.25259/ijdvl_1322_2023","DOIUrl":"https://doi.org/10.25259/ijdvl_1322_2023","url":null,"abstract":"Bacterial vaginosis (BV), characterised by an imbalance in vaginal microbiota, frequently leading to recurrent episodes, has garnered recent research attention due to the significance of biofilms in its pathogenesis. BV biofilms contribute to recurrence by providing a shelter for harmful bacteria, rendering them resistant to conventional treatment. Objectives of this review include characterising BV biofilms, evaluating the limitations of current antibiotic therapy, highlighting emerging solutions and emphasising multifaceted approaches. The review presents data from clinical studies and trials on biofilm-focused treatments which might reduce BV recurrence, with the ultimate goal of improving the quality of life of women with BV and reducing its burden on their reproductive health.","PeriodicalId":513160,"journal":{"name":"Indian Journal of Dermatology, Venereology and Leprology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141680327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Shreya K Gowda, B. Behera, Vishal Thakur, D. K. Sahu, P. Ayyanar, M. Sethy
{"title":"Agminated pigmented papules on the face: A rare presentation of neurofibroma","authors":"Shreya K Gowda, B. Behera, Vishal Thakur, D. K. Sahu, P. Ayyanar, M. Sethy","doi":"10.25259/ijdvl_116_2024","DOIUrl":"https://doi.org/10.25259/ijdvl_116_2024","url":null,"abstract":"","PeriodicalId":513160,"journal":{"name":"Indian Journal of Dermatology, Venereology and Leprology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141683448","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Bing Han, Wei Zhang, Shanshan Li, Hong Wang, Yaping Tian
{"title":"Giant syringocystadenoma papilliferum along the Blaschko’s lines","authors":"Bing Han, Wei Zhang, Shanshan Li, Hong Wang, Yaping Tian","doi":"10.25259/ijdvl_659_2023","DOIUrl":"https://doi.org/10.25259/ijdvl_659_2023","url":null,"abstract":"","PeriodicalId":513160,"journal":{"name":"Indian Journal of Dermatology, Venereology and Leprology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141680653","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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