Pub Date : 2024-07-03DOI: 10.25259/ijdvl_1337_2023
Jinghui Sun, Xiaopo Wang
{"title":"Pemphigus foliaceous accompanied by new erythema annulare centrifugum like lesions","authors":"Jinghui Sun, Xiaopo Wang","doi":"10.25259/ijdvl_1337_2023","DOIUrl":"https://doi.org/10.25259/ijdvl_1337_2023","url":null,"abstract":"","PeriodicalId":513160,"journal":{"name":"Indian Journal of Dermatology, Venereology and Leprology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141682582","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Clustering of varicella over active superficial dermatophytosis: An underreported co-existence","authors":"Kumari Sweta Leena Patra, V. Hanumanthu, K. Vinay","doi":"10.25259/ijdvl_708_2023","DOIUrl":"https://doi.org/10.25259/ijdvl_708_2023","url":null,"abstract":"","PeriodicalId":513160,"journal":{"name":"Indian Journal of Dermatology, Venereology and Leprology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141682629","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Androgenetic alopecia, also known as male pattern baldness, is a common form of hair loss influenced by environmental, hormonal, and genetic factors. According to recent research, the PITX2 gene may play a key role in the pathophysiology of androgenetic alopecia (AGA). This study examines the association between genetic variants of the PITX2 gene and AGA risk. The genomic DNA was extracted from peripheral blood samples collected from 70 male AGA patients and 60 non-androgenetic alopecia controls. The isolated DNA was quantified and the genotype for three PITX2 polymorphisms (rs2200733, rs10033464, and rs13143308) was identified using TaqMan assays. The statistical analysis was done to determine the allele frequency of genetic variants between AGA and non-AGA groups. The demographic profile of the study population showed that the AGA and non-AGA groups differed in age. The AGA group had higher blood pressure, a higher prevalence of smoking, alcohol consumption, metabolic syndrome, insulin resistance, and a higher incidence of family history. Through genetic analysis, significant correlations were found between AGA risk and specific PITX2 polymorphisms, significantly with the rs2200733 allele (OR = 6.08, p < 0.001*), the rs1003464 G allele (OR = 2.02, p < 0.019*) and the rs13143308 showed GT genotype (OR = 4.26, p < 0.001*). Based on our findings, the PITX2 polymorphisms may play a vital role in the development of AGA. This study also found the interactions between genetic and environmental factors in AGA pathogenesis.
雄激素性脱发又称男性型秃发，是受环境、激素和遗传因素影响的一种常见脱发形式。本研究探讨了 PITX2 基因的遗传变异与 AGA 风险之间的关联。研究人员从 70 名男性 AGA 患者和 60 名非雄激素性脱发对照者的外周血样本中提取了基因组 DNA。通过TaqMan测定法对分离的DNA进行定量，并确定三种PITX2多态性（rs2200733、rs10033464和rs13143308）的基因型。研究人群的人口统计学特征显示，AGA 组和非 AGA 组在年龄上存在差异。AGA组的血压更高，吸烟、饮酒、代谢综合征、胰岛素抵抗的发生率更高，家族史的发生率也更高。通过基因分析发现，AGA风险与特定的PITX2多态性之间存在明显的相关性，其中rs2200733等位基因（OR=6.08，p＜0.001*）、rs1003464 G等位基因（OR=2.02，p＜0.019*）和rs13143308显示GT基因型（OR=4.26，p＜0.001*）显著相关。本研究还发现了遗传因素和环境因素在AGA发病机制中的相互作用。
{"title":"Association between PITX2 polymorphism and androgenetic alopecia in the Indian population","authors":"Manoranjani Murugan, I. Sadasivam, Aarthi Manoharan, Swetha Jayakumar, Yogesh Vetriselvan, Melissa Shaelyn Samuel, Ravikumar Sambandam","doi":"10.25259/ijdvl_1147_2023","DOIUrl":"https://doi.org/10.25259/ijdvl_1147_2023","url":null,"abstract":"\u0000\u0000Androgenetic alopecia, also known as male pattern baldness, is a common form of hair loss influenced by environmental, hormonal, and genetic factors. According to recent research, the PITX2 gene may play a key role in the pathophysiology of androgenetic alopecia (AGA).\u0000\u0000\u0000\u0000This study examines the association between genetic variants of the PITX2 gene and AGA risk.\u0000\u0000\u0000\u0000The genomic DNA was extracted from peripheral blood samples collected from 70 male AGA patients and 60 non-androgenetic alopecia controls. The isolated DNA was quantified and the genotype for three PITX2 polymorphisms (rs2200733, rs10033464, and rs13143308) was identified using TaqMan assays. The statistical analysis was done to determine the allele frequency of genetic variants between AGA and non-AGA groups.\u0000\u0000\u0000\u0000The demographic profile of the study population showed that the AGA and non-AGA groups differed in age. The AGA group had higher blood pressure, a higher prevalence of smoking, alcohol consumption, metabolic syndrome, insulin resistance, and a higher incidence of family history. Through genetic analysis, significant correlations were found between AGA risk and specific PITX2 polymorphisms, significantly with the rs2200733 allele (OR = 6.08, p < 0.001*), the rs1003464 G allele (OR = 2.02, p < 0.019*) and the rs13143308 showed GT genotype (OR = 4.26, p < 0.001*).\u0000\u0000\u0000\u0000Based on our findings, the PITX2 polymorphisms may play a vital role in the development of AGA. This study also found the interactions between genetic and environmental factors in AGA pathogenesis.\u0000","PeriodicalId":513160,"journal":{"name":"Indian Journal of Dermatology, Venereology and Leprology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141683924","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Anas Kololichalil, S. Jinkala, Sivaranjini Ramassamy
{"title":"Normal hair follicle counts from scalp biopsy of Indian ethnicity: A cross-sectional study","authors":"Anas Kololichalil, S. Jinkala, Sivaranjini Ramassamy","doi":"10.25259/ijdvl_230_2024","DOIUrl":"https://doi.org/10.25259/ijdvl_230_2024","url":null,"abstract":"","PeriodicalId":513160,"journal":{"name":"Indian Journal of Dermatology, Venereology and Leprology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141684037","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Eccrine poroma on the abdomen: A rare and atypical site","authors":"S. Neema, Anand Mannu, B. Vasudevan, Silky Priya","doi":"10.25259/ijdvl_331_2024","DOIUrl":"https://doi.org/10.25259/ijdvl_331_2024","url":null,"abstract":"","PeriodicalId":513160,"journal":{"name":"Indian Journal of Dermatology, Venereology and Leprology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141683572","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Vitiligo is an acquired disorder of pigmentation with an elusive pathogenesis, though various theories have been proposed. The presence of peri-lesional autoreactive CD8+ T cell infiltrate suggests the involvement of abnormal immune responses and autoimmunity in vitiligo. Recent studies have identified the IFN-γ-CXCL9/CXCL-10 axis as a key component of the autoimmune response that perpetuates disease activity in vitiligo. The primary objective was to estimate serum CXCL9 and CXCL10 levels in vitiligo patients compared to age- and sex-matched controls. Additionally, the study aimed to find correlations between CXCL9 and CXCL10 levels and disease severity and stability. Secondary objectives included comparing levels in segmental/nonsegmental vitiligo and stable/progressive vitiligo and assessing the impact of age and gender. A hospital-based cross-sectional study included 60 vitiligo patients and 30 age- and sex-matched controls. Serum levels of CXCL9 and CXCL10 were assessed using Enzyme-linked immunosorbent assay (ELISA). Cases were clinically evaluated for the type of vitiligo (segmental or non-segmental), disease severity (VASI score), and disease stability (VIDA score). Statistical analysis included t-tests, chi-square tests, and correlation coefficients. P value less than 0.5 was taken as significant. Serum CXCL9 and CXCL10, both, were significantly raised in vitiligo patients as compared to controls (p-value = 0.001* & 0.001* respectively) and correlated positively with both VASI score (p-value = 0.001* & 0.001* respectively) and with VIDA score (p-value = 0.032* & 0.001* respectively). Serum CXCL10 showed significant elevation in progressive vitiligo, and CXCL9 exhibited a non-significant trend. No significant difference was observed between segmental and non-segmental vitiligo. Both chemokines positively correlated with disease severity and stability, while age and gender did not significantly impact chemokine levels. The expression of chemokines CXCL9 and CXCL10 is markedly increased and correlated positively with disease severity & instability, underscoring their mechanistic role in vitiligo pathogenesis. The values were also higher in the progressive group than in the stable group, inferring their conceivable potential as serum biomarkers. Both serum CXCL9 and CXCL10 were significantly elevated in vitiligo patients compared to controls and they can be used as potential serum biomarkers for assessing the disease activity. Small sample size of control population. The voluntary sampling technique led to an unequal number of patients in progressive and stable vitiligo groups, as well as in segmental and non-segmental groups. The current study did not include blister fluid analysis and the effect of therapy on the chemokine levels. The expression of chemokines CXCL9 and CXCL10 is markedly increased and correlates positively with disease severity and instability, underscoring their mechanistic role in vitiligo pathogenesis
白癜风是一种获得性色素脱失症，其发病机制难以捉摸，但已有多种理论提出。皮损周围自反应性 CD8+ T 细胞浸润的存在表明，异常免疫反应和自身免疫参与了白癜风的发病。最近的研究发现，IFN-γ-CXCL9/CXCL-10 轴是自身免疫反应的一个关键组成部分，它使白癜风的疾病活动持续存在。此外，该研究还旨在发现CXCL9和CXCL10水平与疾病严重程度和稳定性之间的相关性。次要目标包括比较节段型/非节段型白癜风和稳定期/进展期白癜风的水平，以及评估年龄和性别的影响。这项以医院为基础的横断面研究包括60名白癜风患者和30名年龄和性别匹配的对照组。采用酶联免疫吸附试验（ELISA）评估血清中CXCL9和CXCL10的水平。临床评估病例的白癜风类型（节段型或非节段型）、疾病严重程度（VASI评分）和疾病稳定性（VIDA评分）。统计分析包括 t 检验、卡方检验和相关系数。与对照组相比，白癜风患者的血清 CXCL9 和 CXCL10 均显著升高（p 值分别为 0.001* 和 0.001*），并与 VASI 评分（p 值分别为 0.001* 和 0.001*）和 VIDA 评分（p 值分别为 0.032* 和 0.001*）呈正相关。血清 CXCL10 在进展期白癜风中明显升高，而 CXCL9 则无明显趋势。节段性和非节段性白癜风之间没有明显差异。趋化因子CXCL9和CXCL10的表达明显增加，并与疾病的严重程度和不稳定性呈正相关，强调了它们在白癜风发病机制中的作用。进展期组的CXCL9和CXCL10值也高于稳定期组，这说明它们有可能成为血清生物标记物。与对照组相比，白癜风患者血清中的CXCL9和CXCL10均明显升高，可作为潜在的血清生物标志物用于评估疾病的活动性。自愿抽样技术导致进展期和稳定期白癜风组、节段型和非节段型白癜风组的患者人数不均等。趋化因子CXCL9和CXCL10的表达明显增加，并与疾病的严重程度和不稳定性呈正相关，强调了它们在白癜风发病机制中的作用。进展期组的数值也高于稳定期组，这推断出它们有可能成为血清生物标志物。
{"title":"Differential expression of serum CXCL9 and CXCL10 levels in vitiligo patients and their correlation with disease severity and stability: A cross-sectional study","authors":"Shayna Aulakh, Seema Goel, Loveleen Kaur, Samridhi Gulati, Maninder Kaur, D. Chopra, Rishu Sarangal, Jayati Batra","doi":"10.25259/ijdvl_793_2023","DOIUrl":"https://doi.org/10.25259/ijdvl_793_2023","url":null,"abstract":"\u0000\u0000Vitiligo is an acquired disorder of pigmentation with an elusive pathogenesis, though various theories have been proposed. The presence of peri-lesional autoreactive CD8+ T cell infiltrate suggests the involvement of abnormal immune responses and autoimmunity in vitiligo. Recent studies have identified the IFN-γ-CXCL9/CXCL-10 axis as a key component of the autoimmune response that perpetuates disease activity in vitiligo.\u0000\u0000\u0000\u0000The primary objective was to estimate serum CXCL9 and CXCL10 levels in vitiligo patients compared to age- and sex-matched controls. Additionally, the study aimed to find correlations between CXCL9 and CXCL10 levels and disease severity and stability. Secondary objectives included comparing levels in segmental/nonsegmental vitiligo and stable/progressive vitiligo and assessing the impact of age and gender.\u0000\u0000\u0000\u0000A hospital-based cross-sectional study included 60 vitiligo patients and 30 age- and sex-matched controls. Serum levels of CXCL9 and CXCL10 were assessed using Enzyme-linked immunosorbent assay (ELISA). Cases were clinically evaluated for the type of vitiligo (segmental or non-segmental), disease severity (VASI score), and disease stability (VIDA score). Statistical analysis included t-tests, chi-square tests, and correlation coefficients. P value less than 0.5 was taken as significant.\u0000\u0000\u0000\u0000Serum CXCL9 and CXCL10, both, were significantly raised in vitiligo patients as compared to controls (p-value = 0.001* & 0.001* respectively) and correlated positively with both VASI score (p-value = 0.001* & 0.001* respectively) and with VIDA score (p-value = 0.032* & 0.001* respectively). Serum CXCL10 showed significant elevation in progressive vitiligo, and CXCL9 exhibited a non-significant trend. No significant difference was observed between segmental and non-segmental vitiligo. Both chemokines positively correlated with disease severity and stability, while age and gender did not significantly impact chemokine levels.\u0000\u0000\u0000\u0000The expression of chemokines CXCL9 and CXCL10 is markedly increased and correlated positively with disease severity & instability, underscoring their mechanistic role in vitiligo pathogenesis. The values were also higher in the progressive group than in the stable group, inferring their conceivable potential as serum biomarkers. Both serum CXCL9 and CXCL10 were significantly elevated in vitiligo patients compared to controls and they can be used as potential serum biomarkers for assessing the disease activity.\u0000\u0000\u0000\u0000Small sample size of control population. The voluntary sampling technique led to an unequal number of patients in progressive and stable vitiligo groups, as well as in segmental and non-segmental groups. The current study did not include blister fluid analysis and the effect of therapy on the chemokine levels.\u0000\u0000\u0000\u0000The expression of chemokines CXCL9 and CXCL10 is markedly increased and correlates positively with disease severity and instability, underscoring their mechanistic role in vitiligo pathogenesis","PeriodicalId":513160,"journal":{"name":"Indian Journal of Dermatology, Venereology and Leprology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141683033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
R. Choudhary, Prashant Bharti, Avik Mondal, Somesh Gupta
{"title":"Radiofrequency-assisted fractional thermolysis for drug delivery in Keloids","authors":"R. Choudhary, Prashant Bharti, Avik Mondal, Somesh Gupta","doi":"10.25259/ijdvl_647_2023","DOIUrl":"https://doi.org/10.25259/ijdvl_647_2023","url":null,"abstract":"","PeriodicalId":513160,"journal":{"name":"Indian Journal of Dermatology, Venereology and Leprology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141682596","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-01DOI: 10.25259/ijdvl_1280_2023
Rachel C Hill, Yu Wang, Bilal Shaikh, Paul J. Christos, Shari R. Lipner
{"title":"Frequent potassium monitoring is associated with hyperkalemia that is clinically insignificant in females taking spironolactone for dermatologic conditions","authors":"Rachel C Hill, Yu Wang, Bilal Shaikh, Paul J. Christos, Shari R. Lipner","doi":"10.25259/ijdvl_1280_2023","DOIUrl":"https://doi.org/10.25259/ijdvl_1280_2023","url":null,"abstract":"","PeriodicalId":513160,"journal":{"name":"Indian Journal of Dermatology, Venereology and Leprology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141714762","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Alopecia areata (AA), a disorder of non-scarring hair loss with a variable relapsing and remitting course, is a common autoimmune disease in children. Although it often presents as several focal small patchy bald lesions, early onset AA can lead to a total loss of scalp hair, even body hairs, a severe subtype. Atopic diseases are common concurrent disorders in AA, especially among those with early onset severe type of hair loss. Whether atopic diseases increase the risk of AA in the paediatric population of Taiwan, remains unclear. To identify if atopic diseases increase the risk of AA among pre-teens and teenagers in Taiwan. From Taiwan National Health Insurance Database 2010, we used the claims data to clarify the risk of AA in pre-teens and teenagers with atopic diseases (atopic dermatitis, allergic conjunctivitis, asthma, allergic rhinitis and food allergy) as compared to the general population. Cox proportional hazards model yielded hazard ratios (HRs) to address the impact of atopic diseases, sex and age on AA risk after adjusting for covariates and subsequent stratified analyses. Overall, 21,070 children (10,535 patients with atopic diseases and 10,535 normal cohort) aged over nine years were recruited. During a follow-up of 15 years, 39 (0.37%) cases were identified to have AA in the atopic diseases group, while 11 (0.10%) had developed AA in the normal cohort. As compared with the normal population, the paediatric population with atopic diseases had a 9.66-fold higher risk of developing AA. The risk was greater for boys and increased with advanced age. In the atopic diseases group, pre-teens and teenagers with food allergies and Sjogren’s syndrome were more likely to have AA. Only one ethnic group. All atopic diseases enhanced the risk of developing AA in Taiwan pre-teens and teenagers. Children with atopic diseases should be monitored to look for the development of AA.
斑秃（Alopecia areata，AA）是一种非瘢痕性脱发疾病，病程多变，可复发和缓解，是儿童常见的自身免疫性疾病。虽然它通常表现为几个局灶性小斑块状秃发病变，但早期发病的 AA 可导致头皮毛发完全脱落，甚至体毛也会脱落，这是一种严重的亚型。特应性疾病是 AA 中常见的并发症，尤其是在早发性严重脱发患者中。从 2010 年台湾国民健康保险数据库中，我们利用理赔数据明确了患有特应性疾病（特应性皮炎、过敏性结膜炎、哮喘、过敏性鼻炎和食物过敏）的学龄前儿童和青少年与普通人群相比患 AA 的风险。在调整协变量并进行分层分析后，Cox 比例危险模型得出了危险比（HRs），以探讨特应性疾病、性别和年龄对 AA 风险的影响。在长达 15 年的随访中，特应性疾病组中有 39 例（0.37%）患 AA，而正常组中有 11 例（0.10%）患 AA。与正常人群相比，患有特应性疾病的儿童患 AA 的风险高出 9.66 倍。男孩的发病风险更高，且随着年龄的增长而增加。在特应性疾病组中，患有食物过敏症和斯约格伦综合症的学龄前儿童和青少年更容易患 AA。患有特应性疾病的儿童应接受监测，以发现 AA 的发生。
{"title":"Atopic diseases and the risk of alopecia areata among pre-teens and teenagers in Taiwan","authors":"Ying‐Yi Lu, Ming-Kung Wu, Chun-Ching Lu, Wei-Ting Wang, Chieh-Hsin Wu","doi":"10.25259/ijdvl_1215_2023","DOIUrl":"https://doi.org/10.25259/ijdvl_1215_2023","url":null,"abstract":"\u0000\u0000Alopecia areata (AA), a disorder of non-scarring hair loss with a variable relapsing and remitting course, is a common autoimmune disease in children. Although it often presents as several focal small patchy bald lesions, early onset AA can lead to a total loss of scalp hair, even body hairs, a severe subtype. Atopic diseases are common concurrent disorders in AA, especially among those with early onset severe type of hair loss. Whether atopic diseases increase the risk of AA in the paediatric population of Taiwan, remains unclear.\u0000\u0000\u0000\u0000To identify if atopic diseases increase the risk of AA among pre-teens and teenagers in Taiwan.\u0000\u0000\u0000\u0000From Taiwan National Health Insurance Database 2010, we used the claims data to clarify the risk of AA in pre-teens and teenagers with atopic diseases (atopic dermatitis, allergic conjunctivitis, asthma, allergic rhinitis and food allergy) as compared to the general population. Cox proportional hazards model yielded hazard ratios (HRs) to address the impact of atopic diseases, sex and age on AA risk after adjusting for covariates and subsequent stratified analyses.\u0000\u0000\u0000\u0000Overall, 21,070 children (10,535 patients with atopic diseases and 10,535 normal cohort) aged over nine years were recruited. During a follow-up of 15 years, 39 (0.37%) cases were identified to have AA in the atopic diseases group, while 11 (0.10%) had developed AA in the normal cohort. As compared with the normal population, the paediatric population with atopic diseases had a 9.66-fold higher risk of developing AA. The risk was greater for boys and increased with advanced age. In the atopic diseases group, pre-teens and teenagers with food allergies and Sjogren’s syndrome were more likely to have AA.\u0000\u0000\u0000\u0000Only one ethnic group.\u0000\u0000\u0000\u0000All atopic diseases enhanced the risk of developing AA in Taiwan pre-teens and teenagers. Children with atopic diseases should be monitored to look for the development of AA. \u0000","PeriodicalId":513160,"journal":{"name":"Indian Journal of Dermatology, Venereology and Leprology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141698743","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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