Journal of Allergy and Clinical Immunology-In Practice最新文献

{"title":"Characterization and Incidence of Sunflower Seed Allergy in a Pediatric Allergy Clinic","authors":"Elsa R. Treffeisen MD, MPH ,&nbsp;Claire Mepyans BA ,&nbsp;Ellen R. Conroy MD ,&nbsp;Heather J. Baer ScD ,&nbsp;David N. Williams PhD ,&nbsp;Kathryn A. Williams MS ,&nbsp;Lynda C. Schneider MD","doi":"10.1016/j.jaip.2024.07.029","DOIUrl":"10.1016/j.jaip.2024.07.029","url":null,"abstract":"<div><h3>Background</h3><div>Sunflower seeds are a popular allergen-free peanut alternative.</div></div><div><h3>Objective</h3><div>To describe sunflower seed allergy incidence and characteristics.</div></div><div><h3>Methods</h3><div>We conducted a retrospective cohort study of patients with sunflower seed allergy from 1995 to 2021 in a pediatric allergy clinic. We described demographic characteristics, testing results, atopic comorbidities, and reaction histories of patients with sunflower seed allergy and calculated the annual cumulative incidence of the allergy. Logistic regression was used to estimate the increase in odds of sunflower seed allergy diagnosis for each year from 1995 to 2021.</div></div><div><h3>Results</h3><div>From 1995 to 2021, we identified 235 patients with sunflower seed allergy. Among patients with sunflower seed allergy, the median age at diagnosis was 3.9 years. More than three-quarters of patients had another atopic condition. Half of the reactions consisted of mild urticaria or rash, and a quarter met criteria for anaphylaxis. The cumulative incidence ranged from 0% (1995-1999, 2001-2004, and 2006) to 0.38% (2021). From 1995 to 2021, the odds of sunflower seed allergy diagnosis increased annually by 21% (odds ratio, 1.21; 95% CI, 1.17-1.25).</div></div><div><h3>Conclusions</h3><div>In our single-center cohort of children with sunflower seed allergy, most children were diagnosed in early childhood, had high rates of comorbid atopic conditions, and had high rates of cutaneous reactions to sunflower seed products. Moreover, in our cohort, incidence of sunflower seed allergy increased.</div></div>","PeriodicalId":51323,"journal":{"name":"Journal of Allergy and Clinical Immunology-In Practice","volume":"12 11","pages":"Pages 3081-3088.e6"},"PeriodicalIF":8.2,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141908262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Belgian IgE study: Staphylococcus aureus toxins in adult severe asthma","authors":"Florence Schleich MD, PhD ,&nbsp;Eléonore Maury PhD ,&nbsp;Claus Bachert MD, PhD ,&nbsp;Mieke Jansen PhD ,&nbsp;Sandra Gurdain MD ,&nbsp;Jan Van Schoor MD, PhD","doi":"10.1016/j.jaip.2024.08.016","DOIUrl":"10.1016/j.jaip.2024.08.016","url":null,"abstract":"","PeriodicalId":51323,"journal":{"name":"Journal of Allergy and Clinical Immunology-In Practice","volume":"12 11","pages":"Pages 3139-3142.e1"},"PeriodicalIF":8.2,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141996923","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of Biologics in NSAID-ERD: United Airways From the Nose to the Bronchi","authors":"","doi":"10.1016/j.jaip.2024.10.003","DOIUrl":"10.1016/j.jaip.2024.10.003","url":null,"abstract":"","PeriodicalId":51323,"journal":{"name":"Journal of Allergy and Clinical Immunology-In Practice","volume":"12 11","pages":"Page 2933"},"PeriodicalIF":8.2,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142662911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transient Serpentine Supravenous Erythema During Rapid Drug Desensitization","authors":"Malina C. Patel MD ,&nbsp;Dan Costin MD ,&nbsp;Beth McLellan MD ,&nbsp;Sara DiFalco RN ,&nbsp;Jessica Oh MD","doi":"10.1016/j.jaip.2024.08.031","DOIUrl":"10.1016/j.jaip.2024.08.031","url":null,"abstract":"","PeriodicalId":51323,"journal":{"name":"Journal of Allergy and Clinical Immunology-In Practice","volume":"12 11","pages":"Pages 3123-3125"},"PeriodicalIF":8.2,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142074528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Consultation for Chronic Rhinosinusitis With Nasal Polyps and Asthma: Clinical Presentation, Diagnostic Workup, and Treatment Options","authors":"Anju T. Peters MD ,&nbsp;Bruce K. Tan MD ,&nbsp;Whitney W. Stevens MD, PhD","doi":"10.1016/j.jaip.2024.07.019","DOIUrl":"10.1016/j.jaip.2024.07.019","url":null,"abstract":"<div><div>Chronic rhinosinusitis (CRS) is characterized by chronic inflammation of the sinonasal mucosa, affects over 12% of the US population, and costs over $20 billion annually. CRS can be divided into 2 major phenotypes based on whether nasal polyps are present (chronic rhinosinusitis with nasal polyps [CRSwNP]) or absent (chronic rhinosinusitis without nasal polyps). This grand rounds review will discuss the clinical approach to patients with CRSwNP, including typical presentations, workup, and currently available treatment options. Tools that physicians can use to assess subjective sinonasal symptoms, as well as objective measures of disease, will be reviewed. Additional focus will be on recognizing clinical comorbidities commonly associated with CRSwNP, including asthma, bronchiectasis, allergic rhinitis, and nonsteroidal anti-inflammatory drug–exacerbated respiratory disease. Clinical outcomes can be improved by providing a comprehensive approach to evaluating (and managing) patients with CRSwNP.</div></div>","PeriodicalId":51323,"journal":{"name":"Journal of Allergy and Clinical Immunology-In Practice","volume":"12 11","pages":"Pages 2898-2905"},"PeriodicalIF":8.2,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141876619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Induction of sustained remission and reversal of pathologic transcriptome achieved with tezepelumab in an adolescent with eosinophilic esophagitis","authors":"Colby S. Sharlin MD ,&nbsp;Margaret H. Collins MD ,&nbsp;Scott M. Bolton MD ,&nbsp;Garrett A. Osswald BS ,&nbsp;Ghassan S. Safadi MD ,&nbsp;Kara L. Kliewer RD, PhD ,&nbsp;Marc E. Rothenberg MD, PhD ,&nbsp;Tetsuo Shoda MD, PhD ,&nbsp;Vincent A. Mukkada MD","doi":"10.1016/j.jaip.2024.08.013","DOIUrl":"10.1016/j.jaip.2024.08.013","url":null,"abstract":"","PeriodicalId":51323,"journal":{"name":"Journal of Allergy and Clinical Immunology-In Practice","volume":"12 11","pages":"Pages 3147-3149.e2"},"PeriodicalIF":8.2,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141972241","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence and Determinants of Food Allergy in the Era of Early Allergen Introduction: The EarlyNuts Population-Based Study","authors":"Victoria X. Soriano PhD ,&nbsp;Katrina J. Allen MBBS, PhD ,&nbsp;Shyamali C. Dharmage MBBS, PhD ,&nbsp;Desalegn Markos Shifti PhD ,&nbsp;Kirsten P. Perrett MBBS, PhD ,&nbsp;Rushani Wijesuriya PhD ,&nbsp;Jennifer J. Koplin PhD ,&nbsp;Rachel L. Peters PhD","doi":"10.1016/j.jaip.2024.07.001","DOIUrl":"10.1016/j.jaip.2024.07.001","url":null,"abstract":"<div><h3>Background</h3><div>Infant feeding guidelines in Australia changed in 2016 to recommend introducing common allergy-causing foods by age 1 year to prevent food allergy. Although most Australian infants now eat peanut and egg by age 6 months, some still develop food allergy despite the early introduction of allergens.</div></div><div><h3>Objectives</h3><div>To describe the prevalence of food allergy in a cohort recruited after introducing the nationwide allergy prevention recommendations; identify characteristics of infants who developed allergy despite early introduction of allergens; and estimate the causal effect of modifiable exposures on food allergy prevalence and whether this differed between infants who were introduced to allergens before or after age 6 months.</div></div><div><h3>Methods</h3><div>We recruited a population-based sample of 12-month-old infants in Melbourne, Australia. Infants had skin prick tests to four foods and parents completed questionnaires. Infants with evidence of sensitization were offered oral food challenges. Prevalence estimates were adjusted using inverse probability weighting.</div></div><div><h3>Results</h3><div>In a cohort of infants (n = 1,420) in which nearly all infants had been introduced to common allergens such as egg, milk, and peanut by age 1 year, the prevalence of food allergy remained high at 11.3% (95% CI, 9.6-13.4). Infants who developed food allergy despite introduction of the allergen by age 6 months were more likely to have Asian-born parents. Early-onset moderate or severe eczema was associated with an increased odds of food allergy irrespective of whether allergens were introduced before or after age 6 months. Among infants who were introduced to peanut at age 6 months or earlier, antibiotic use by age 6 months was associated with an increased odds of peanut allergy (adjusted odds ratio = 6.03; 95% CI, 1.15-31.60).</div></div><div><h3>Conclusions</h3><div>In a cohort in which early allergen introduction was common, the prevalence of food allergy remained high. Infants who developed food allergy despite introduction of the respective allergen by age 6 months were more likely to have had Asian parents and early-onset eczema. New interventions are needed for infants with a phenotype of food allergy that is not amenable to early allergen introduction.</div></div>","PeriodicalId":51323,"journal":{"name":"Journal of Allergy and Clinical Immunology-In Practice","volume":"12 11","pages":"Pages 3068-3078.e3"},"PeriodicalIF":8.2,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141592091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tree nut testing and diagnosis in infants undergoing screening for peanut allergy","authors":"Adam Pearlstein DO,&nbsp;Irene Mikhail MD,&nbsp;Rebecca Scherzer MD,&nbsp;David R. Stukus MD,&nbsp;Benjamin T. Prince MD, MSCI","doi":"10.1016/j.jaip.2024.07.030","DOIUrl":"10.1016/j.jaip.2024.07.030","url":null,"abstract":"","PeriodicalId":51323,"journal":{"name":"Journal of Allergy and Clinical Immunology-In Practice","volume":"12 11","pages":"Pages 3153-3154.e1"},"PeriodicalIF":8.2,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141908263","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic accuracy of maternal diet measures for offspring allergy","authors":"Carina Venter PhD, RD ,&nbsp;Kaci Pickett-Nairne MS ,&nbsp;Donald Leung MD, PhD ,&nbsp;David Fleischer MD ,&nbsp;Liam O’Mahony PhD ,&nbsp;Deborah H. Glueck PhD ,&nbsp;Dana Dabelea MD, PhD","doi":"10.1016/j.jaip.2024.08.017","DOIUrl":"10.1016/j.jaip.2024.08.017","url":null,"abstract":"","PeriodicalId":51323,"journal":{"name":"Journal of Allergy and Clinical Immunology-In Practice","volume":"12 11","pages":"Pages 3166-3168.e1"},"PeriodicalIF":8.2,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141996921","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Yao syndrome in a child with C2 deficiency","authors":"Samantha Cresoe-Ortiz MD ,&nbsp;Geoffrey Hall DO ,&nbsp;Rachel L. Randell MD, MSCR ,&nbsp;Monica G. Lawrence MD ,&nbsp;Aarat Patel MD ,&nbsp;Christina Peroutka MD ,&nbsp;Qingping Yao MD, PhD ,&nbsp;Talal Mousallem MD","doi":"10.1016/j.jaip.2024.08.018","DOIUrl":"10.1016/j.jaip.2024.08.018","url":null,"abstract":"","PeriodicalId":51323,"journal":{"name":"Journal of Allergy and Clinical Immunology-In Practice","volume":"12 11","pages":"Pages 3159-3162"},"PeriodicalIF":8.2,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141996924","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}