{"title":"GC-MS Determination and In Vitro Antioxidant Activity of the Aerial Part of Phyllanthus parvifolius from the Indian Himalayas","authors":"Jasneet Kour, Shagun Sharma, Pratibha Sharma, Shivani Sharma, Harcharan Singh Dhaliwal, Vivek Sharma","doi":"10.1007/s10600-024-04547-5","DOIUrl":"10.1007/s10600-024-04547-5","url":null,"abstract":"","PeriodicalId":514,"journal":{"name":"Chemistry of Natural Compounds","volume":"60 6","pages":"1163 - 1165"},"PeriodicalIF":0.8,"publicationDate":"2024-11-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142645630","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-11-09DOI: 10.1007/s10600-024-04534-w
Selim Ozdemir, Seyithan Seydosoglu, Kagan Kokten, Abdullah Cil
{"title":"Lipid Contents and Fatty Acid Compositions of Grains of Italian Ryegrass Varieties","authors":"Selim Ozdemir, Seyithan Seydosoglu, Kagan Kokten, Abdullah Cil","doi":"10.1007/s10600-024-04534-w","DOIUrl":"10.1007/s10600-024-04534-w","url":null,"abstract":"","PeriodicalId":514,"journal":{"name":"Chemistry of Natural Compounds","volume":"60 6","pages":"1126 - 1129"},"PeriodicalIF":0.8,"publicationDate":"2024-11-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142645614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-11-09DOI: 10.1007/s10600-024-04526-w
Nesimi Uludag
In a one-step reaction, we introduce that novel synthetic routes of a tetrahydrozarbazole derivative bearing a caboxylmethylene side chain exist at the C-2 position. Upon treatment with DDQ, it undergoes the cyclization reaction of amide (6) for the synthesis of methanoazocino[4,3-b]indole. Furthermore, the reduction of compound 9 with LiALH4 in refluxing THF-furnished tubifolidine 10 via an eight-step synthetic sequence, which involves the synthesis of compound 3 in one step, is the crucial step. The structures of all currently synthesized compounds were confirmed using spectroscopic techniques (1H NMR, 13C NMR, FT-IR).
{"title":"A New Strategy for the Total Synthesis of Pentacyclic Tubifolidine","authors":"Nesimi Uludag","doi":"10.1007/s10600-024-04526-w","DOIUrl":"10.1007/s10600-024-04526-w","url":null,"abstract":"<p>In a one-step reaction, we introduce that novel synthetic routes of a tetrahydrozarbazole derivative bearing a caboxylmethylene side chain exist at the C-2 position. Upon treatment with DDQ, it undergoes the cyclization reaction of amide (<b>6</b>) for the synthesis of methanoazocino[4,3-b]indole. Furthermore, the reduction of compound <b>9</b> with LiALH<sub>4</sub> in refluxing THF-furnished tubifolidine <b>10</b> via an eight-step synthetic sequence, which involves the synthesis of compound <b>3</b> in one step, is the crucial step. The structures of all currently synthesized compounds were confirmed using spectroscopic techniques (<sup>1</sup>H NMR, <sup>13</sup>C NMR, FT-IR).</p>","PeriodicalId":514,"journal":{"name":"Chemistry of Natural Compounds","volume":"60 6","pages":"1091 - 1095"},"PeriodicalIF":0.8,"publicationDate":"2024-11-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142645615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-11-09DOI: 10.1007/s10600-024-04524-y
Min Yang, Yue-Yu Ma, Rui-Feng Xiong, Miao Dong, Qiu-Fen Hu, Yin-Ke Li
N-(5-((3E,5E)-10-Acetoxy-5,7,9,11-tetramethyltrideca-3,5-dien-1-yl)-2-oxotetrahydrofuran-3-yl)acetamide (1), a new amide compound, and five known ones (2–6) were isolated from the EtOH extract of the solid culture of Fusarium sp. Their structures were determined by means of extensive 1D and 2D NMR techniques, as well as comparison with literature values. Additionally, compounds 1–6 were tested for their cytotoxic activities. The results showed that compounds 2, 3, 6 exhibited cytotoxic activities against five human cancer cell lines with IC50 values ranging from 2.088 to 26.40 μM.
{"title":"A New Amide from the Fermentation of Fusarium sp. SFS-G3 and Cytotoxic Activities","authors":"Min Yang, Yue-Yu Ma, Rui-Feng Xiong, Miao Dong, Qiu-Fen Hu, Yin-Ke Li","doi":"10.1007/s10600-024-04524-y","DOIUrl":"10.1007/s10600-024-04524-y","url":null,"abstract":"<p><i>N</i>-(5-((3E,5E)-10-Acetoxy-5,7,9,11-tetramethyltrideca-3,5-dien-1-yl)-2-oxotetrahydrofuran-3-yl)acetamide (<b>1</b>), a new amide compound, and five known ones (<b>2–6</b>) were isolated from the EtOH extract of the solid culture of <i>Fusarium</i> sp. Their structures were determined by means of extensive 1D and 2D NMR techniques, as well as comparison with literature values. Additionally, compounds <b>1–6</b> were tested for their cytotoxic activities. The results showed that compounds <b>2</b>, <b>3</b>, <b>6</b> exhibited cytotoxic activities against five human cancer cell lines with IC<sub>50</sub> values ranging from 2.088 to 26.40 μM.</p>","PeriodicalId":514,"journal":{"name":"Chemistry of Natural Compounds","volume":"60 6","pages":"1080 - 1083"},"PeriodicalIF":0.8,"publicationDate":"2024-11-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142645613","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-11-08DOI: 10.1007/s10600-024-04543-9
Abubakar Siddiq Salihu, Wan Mohd Nuzul Hakimi Wan Salleh, Nurunajah Ab Ghani
{"title":"Identification of Volatile Oil Components of Croton oblongus","authors":"Abubakar Siddiq Salihu, Wan Mohd Nuzul Hakimi Wan Salleh, Nurunajah Ab Ghani","doi":"10.1007/s10600-024-04543-9","DOIUrl":"10.1007/s10600-024-04543-9","url":null,"abstract":"","PeriodicalId":514,"journal":{"name":"Chemistry of Natural Compounds","volume":"60 6","pages":"1153 - 1154"},"PeriodicalIF":0.8,"publicationDate":"2024-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142645584","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-11-08DOI: 10.1007/s10600-024-04512-2
Shao-Hua Xu, Wen Xu, Yuan-Biao He, Yong Zhao
Our continuous phytochemical investigation of the twigs and leaves of Syzygium austroyunnanense has led to the isolation of two new phloroglucinol derivatives, austroyunone F (1) and austroyunone G (2). Their structures were determined via extensive spectroscopic data including NMR along with HR-ESI-MS. Compound 1 showed significant inhibitory activity with an IC50 value of 2.64 μM against α-glucosidase.
我们对乌苏里南茜草的树枝和树叶进行了持续的植物化学研究，分离出了两种新的氯代葡萄糖苷衍生物：乌苏里南内酯 F (1) 和乌苏里南内酯 G (2)。通过包括核磁共振和 HR-ESI-MS 在内的大量光谱数据确定了它们的结构。化合物 1 对α-葡萄糖苷酶具有明显的抑制活性，其 IC50 值为 2.64 μM。
{"title":"Two New Phloroglucinol Derivatives from Syzygium austroyunnanense","authors":"Shao-Hua Xu, Wen Xu, Yuan-Biao He, Yong Zhao","doi":"10.1007/s10600-024-04512-2","DOIUrl":"10.1007/s10600-024-04512-2","url":null,"abstract":"<p>Our continuous phytochemical investigation of the twigs and leaves of <i>Syzygium austroyunnanense</i> has led to the isolation of two new phloroglucinol derivatives, austroyunone F (<b>1</b>) and austroyunone G (<b>2</b>). Their structures were determined via extensive spectroscopic data including NMR along with HR-ESI-MS. Compound <b>1</b> showed significant inhibitory activity with an IC<sub>50</sub> value of 2.64 μM against α-glucosidase.</p>","PeriodicalId":514,"journal":{"name":"Chemistry of Natural Compounds","volume":"60 6","pages":"1029 - 1032"},"PeriodicalIF":0.8,"publicationDate":"2024-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142645593","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-11-08DOI: 10.1007/s10600-024-04533-x
Na Shen, Yanxia Liu, Ziyao Shao, Huawei Xin, Jun Ma, Yulei Cui
{"title":"Phytochemical Constituents from the Green Walnut Husk of Juglans mandshurica","authors":"Na Shen, Yanxia Liu, Ziyao Shao, Huawei Xin, Jun Ma, Yulei Cui","doi":"10.1007/s10600-024-04533-x","DOIUrl":"10.1007/s10600-024-04533-x","url":null,"abstract":"","PeriodicalId":514,"journal":{"name":"Chemistry of Natural Compounds","volume":"60 6","pages":"1123 - 1125"},"PeriodicalIF":0.8,"publicationDate":"2024-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142645586","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-11-08DOI: 10.1007/s10600-024-04519-9
A. B. Kozhushnaya, S. A. Kolesnikova, A. I. Kalinovsky, R. S. Popov, N. V. Ivanchina
New nor-isomalabaricanic acids 1 and 2 were isolated from polar fractions of the EtOH extract of the Vietnamese sponge Rhabdastrella globostellata using a combination of column chromatography and reversed-phase HPLC. The chemical structures of the new compounds, which were called stellettins W (1) and X (2), were elucidated by analyzing data from NMR experiments and HR-ESI-MS spectra and by comparison with the structures of associated isolated metabolites. Stellettin W was the first isomalabaricane derivative with a 13,14-epoxide group in its structure.
采用柱层析和反相高效液相色谱相结合的方法，从越南海绵Rhabdastrella globostellata的EtOH提取物的极性馏分中分离出了新的去异马拉巴里酸1和2。通过分析核磁共振实验数据和 HR-ESI-MS 图谱，并与相关分离代谢物的结构进行比较，阐明了这些新化合物的化学结构，并将其命名为 Stellettins W (1) 和 X (2)。Stellettin W 是第一个在其结构中含有 13,14-epoxide 基团的异马拉巴里烷衍生物。
{"title":"New Nor-Isomalabaricanic Acids from the Vietnamese Marine Sponge Rhabdastrella globostellata","authors":"A. B. Kozhushnaya, S. A. Kolesnikova, A. I. Kalinovsky, R. S. Popov, N. V. Ivanchina","doi":"10.1007/s10600-024-04519-9","DOIUrl":"10.1007/s10600-024-04519-9","url":null,"abstract":"<p>New <i>nor</i>-isomalabaricanic acids <b>1</b> and <b>2</b> were isolated from polar fractions of the EtOH extract of the Vietnamese sponge <i>Rhabdastrella globostellata</i> using a combination of column chromatography and reversed-phase HPLC. The chemical structures of the new compounds, which were called stellettins W (<b>1</b>) and X (<b>2</b>), were elucidated by analyzing data from NMR experiments and HR-ESI-MS spectra and by comparison with the structures of associated isolated metabolites. Stellettin W was the first isomalabaricane derivative with a 13,14-epoxide group in its structure.</p>","PeriodicalId":514,"journal":{"name":"Chemistry of Natural Compounds","volume":"60 6","pages":"1056 - 1060"},"PeriodicalIF":0.8,"publicationDate":"2024-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142645595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-11-08DOI: 10.1007/s10600-024-04531-z
G. M. Gindullina, T. R. Nugumanov, I. M. Sakhautdinov
A new regioselective approach to the synthesis of 3,4,5-pyrazoles containing a diterpene moiety via 1,3-dipolar cycloaddition of diazoketones obtained from N-maleopimarimide-substituted amino acids to an allenoate was proposed.
{"title":"Synthesis of 3,4,5-Trisubstituted 1H-Pyrazoles Based on Diazoketones with a Diterpene Fragment","authors":"G. M. Gindullina, T. R. Nugumanov, I. M. Sakhautdinov","doi":"10.1007/s10600-024-04531-z","DOIUrl":"10.1007/s10600-024-04531-z","url":null,"abstract":"<p>A new regioselective approach to the synthesis of 3,4,5-pyrazoles containing a diterpene moiety via 1,3-dipolar cycloaddition of diazoketones obtained from <i>N</i>-maleopimarimide-substituted amino acids to an allenoate was proposed.</p>","PeriodicalId":514,"journal":{"name":"Chemistry of Natural Compounds","volume":"60 6","pages":"1114 - 1118"},"PeriodicalIF":0.8,"publicationDate":"2024-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142645599","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
扫码关注我们
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号