Pub Date : 2024-08-06DOI: 10.1007/s10600-024-04414-3
S. A. Fedoreyev, N. P. Mishchenko, D. V. Tarbeeva, E. A. Vasileva, N. D. Pokhilo, V. P. Grigorchuk, A. N. Emelyanov
{"title":"Stilbenes from Stems of Primorsky Grape Variety Alpha and their Antioxidant Activity","authors":"S. A. Fedoreyev, N. P. Mishchenko, D. V. Tarbeeva, E. A. Vasileva, N. D. Pokhilo, V. P. Grigorchuk, A. N. Emelyanov","doi":"10.1007/s10600-024-04414-3","DOIUrl":"10.1007/s10600-024-04414-3","url":null,"abstract":"","PeriodicalId":514,"journal":{"name":"Chemistry of Natural Compounds","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2024-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141933486","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Caneeracone A (1), a new chalcone derivative, together with three known compounds (2–4), was isolated from the seeds of Persea americana Mill. (buccaneer avocado). The structures of these compounds were established by spectroscopic methods including 1D and 2D NMR experiments. Compound 1 exhibited a potent tyrosinase activity with an IC50 of 38.29 μM.
{"title":"New Chalcone Derivative from Persea americana and Its Anti-Tyrosinase Activity","authors":"Parinuch Chumkaew, Saysunee Jumrat, Yutthapong Pianroj","doi":"10.1007/s10600-024-04399-z","DOIUrl":"10.1007/s10600-024-04399-z","url":null,"abstract":"<p>Caneeracone A (<b>1</b>), a new chalcone derivative, together with three known compounds (<b>2–4</b>), was isolated from the seeds of <i>Persea americana</i> Mill. (buccaneer avocado). The structures of these compounds were established by spectroscopic methods including 1D and 2D NMR experiments. Compound <b>1</b> exhibited a potent tyrosinase activity with an IC<sub>50</sub> of 38.29 μM.</p>","PeriodicalId":514,"journal":{"name":"Chemistry of Natural Compounds","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2024-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141933498","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-08-06DOI: 10.1007/s10600-024-04428-x
S. J. Wang, Y. Z. Dong, S. T. Huang, W. J. Li, H. T. Li, S. L. Liu, C. H. Chuang, C. Y. Chen
{"title":"Antiliver and Colorectal Cancer Activity Metabolites of the Leaves of Michelia crassipes","authors":"S. J. Wang, Y. Z. Dong, S. T. Huang, W. J. Li, H. T. Li, S. L. Liu, C. H. Chuang, C. Y. Chen","doi":"10.1007/s10600-024-04428-x","DOIUrl":"10.1007/s10600-024-04428-x","url":null,"abstract":"","PeriodicalId":514,"journal":{"name":"Chemistry of Natural Compounds","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2024-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142410079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-08-06DOI: 10.1007/s10600-024-04401-8
Xupei Men, Jie Song, Xiaomei Song, Xiangdong Qin, Du-Qiang Luo, Jun Zhang
Chemical investigation of Corydalis mucronifera has resulted in the isolation and identification of a pair of new enantiomeric phenolic constituents (±)-mucroniferal D (1) and five known ones (2–6). Their structures were elucidated based on extensive spectroscopic data analysis of MS, 1D and 2D NMR, and their absolute configurations were confirmed by comparison of the optical rotation data. Compounds 1–6 showed moderate cytotoxic activities against MCF-7, MGC-803, and HeLa cell lines with the IC50 values ranging from 22.61–98.30 μg·mL–1.
对 Corydalis mucronifera 进行化学研究的结果是,分离和鉴定了一对新的对映体酚类成分 (±)-mucroniferal D (1) 和五种已知的对映体酚类成分 (2-6)。根据质谱、一维和二维核磁共振的大量光谱数据分析,阐明了它们的结构,并通过比较旋光数据确认了它们的绝对构型。化合物 1-6 对 MCF-7、MGC-803 和 HeLa 细胞株表现出中等程度的细胞毒性活性,IC50 值范围为 22.61-98.30 μg-mL-1。
{"title":"(±)-Mucroniferal D: a Pair of New Phenolic Enantiomers from Corydalis mucronifera","authors":"Xupei Men, Jie Song, Xiaomei Song, Xiangdong Qin, Du-Qiang Luo, Jun Zhang","doi":"10.1007/s10600-024-04401-8","DOIUrl":"10.1007/s10600-024-04401-8","url":null,"abstract":"<p>Chemical investigation of <i>Corydalis mucronifera</i> has resulted in the isolation and identification of a pair of new enantiomeric phenolic constituents (±)-mucroniferal D (<b>1</b>) and five known ones (<b>2–6</b>). Their structures were elucidated based on extensive spectroscopic data analysis of MS, 1D and 2D NMR, and their absolute configurations were confirmed by comparison of the optical rotation data. Compounds <b>1–6</b> showed moderate cytotoxic activities against MCF-7, MGC-803, and HeLa cell lines with the IC<sub>50</sub> values ranging from 22.61–98.30 μg·mL<sup>–1</sup>.</p>","PeriodicalId":514,"journal":{"name":"Chemistry of Natural Compounds","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2024-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141933613","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-08-06DOI: 10.1007/s10600-024-04412-5
N. E. Tseomashko, A. N. Tretyakova, A. Yu. Vasil′kov
Type I collagen was obtained in gel-like form by enzymatic-acidic extraction from cattle tail tendons and was polymerized at room temperature in ammonia vapor to form a transparent film 60.47–64.9 μm thick with good adhesive properties of 11.6–12.4 kPa and tensile strength 559.5–600.5 kPa. The dependence of the film adhesive properties on its ability to stimulate regenerative processes in tissues was found. The collagen was characterized by X-ray photoelectron spectroscopy. The C 1s spectrum showed peaks for C–C/C–H, C–O–C/C–OH, O=C–N, and O=C–OH groups; the N 1s spectrum for C–NH2, O=C–N, and C–NH3+ groups.
{"title":"Preparation and Physicochemical Properties of Collagen for Wound Dressings","authors":"N. E. Tseomashko, A. N. Tretyakova, A. Yu. Vasil′kov","doi":"10.1007/s10600-024-04412-5","DOIUrl":"10.1007/s10600-024-04412-5","url":null,"abstract":"<p>Type I collagen was obtained in gel-like form by enzymatic-acidic extraction from cattle tail tendons and was polymerized at room temperature in ammonia vapor to form a transparent film 60.47–64.9 μm thick with good adhesive properties of 11.6–12.4 kPa and tensile strength 559.5–600.5 kPa. The dependence of the film adhesive properties on its ability to stimulate regenerative processes in tissues was found. The collagen was characterized by X-ray photoelectron spectroscopy. The C 1s spectrum showed peaks for C–C/C–H, C–O–C/C–OH, O=C–N, and O=C–OH groups; the N 1s spectrum for C–NH<sub>2</sub>, O=C–N, and C–NH<sub>3</sub><sup>+</sup> groups.</p>","PeriodicalId":514,"journal":{"name":"Chemistry of Natural Compounds","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2024-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141933484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-08-06DOI: 10.1007/s10600-024-04411-6
A. V. Koval′skaya, A. N. Lobov, D. O. Tsypyshev, Ch.V. Lin, I. P. Tsypysheva
Diels−Alder β-endo adducts of 2-oxomethylcytisine and N-substituted maleimides were synthesized. Their ability to interact with the 6LU7 active site of SARS-CoV-2 main protease Mpro was evaluated in silico. The tested compounds included the potential anti-coronavirus agent (3aR,4S,8S,12S,12aS,12bR)-2-(3-methoxyphenyl)-10-methyl-3a,7,8,9,10,12b-hexahydro-1H-4,12a-etheno-8,12-methanopyrrolo[3′,4′:3,4]pyrido[1,2-a][1,5]diazocine-1,3,5,11(2H,4H,12H)-tetrone, which had calculated characteristics exceeding those of the reference ligand tideglusib.
{"title":"2-Oxomethylcytisine Derivatives with Potential Anti-Coronavirus Activity","authors":"A. V. Koval′skaya, A. N. Lobov, D. O. Tsypyshev, Ch.V. Lin, I. P. Tsypysheva","doi":"10.1007/s10600-024-04411-6","DOIUrl":"10.1007/s10600-024-04411-6","url":null,"abstract":"<p>Diels−Alder <i>β</i>-endo adducts of 2-oxomethylcytisine and <i>N</i>-substituted maleimides were synthesized. Their ability to interact with the 6LU7 active site of SARS-CoV-2 main protease Mpro was evaluated <i>in silico</i>. The tested compounds included the potential anti-coronavirus agent (3aR,4S,8S,12S,12aS,12bR)-2-(3-methoxyphenyl)-10-methyl-3a,7,8,9,10,12b-hexahydro-1H-4,12a-etheno-8,12-methanopyrrolo[3′,4′:3,4]pyrido[1,2-a][1,5]diazocine-1,3,5,11(2H,4H,12H)-tetrone, which had calculated characteristics exceeding those of the reference ligand tideglusib.</p>","PeriodicalId":514,"journal":{"name":"Chemistry of Natural Compounds","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2024-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141933483","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A new cyclic peptide alternarin A (1), along with seven known compounds, alternariol (2), sulfated derivative of alternariol (3), alternariol methyl ether (4), altenuene (5), 2,5-dimethyl-7-hydroxychromone (6), diaporthein A (7), isopterocarpolone (8), were isolated from the betel nut endophytic fungus Alternaria sp. RW-AL. The structure of 1 was elucidated by 1D and 2D NMR spectra as well as HR-ESI-MS analysis. Compounds 1, 4, and 5 showed definite antibacterial activities against Staphylococcus aureus ATCC 6538 and Bacillus subtilis ATCC 6633.
{"title":"A New Cyclic Peptide from Betel Nut Endophytic Fungus Alternaria sp. RW-AL","authors":"Wu Ruan, Qing-Yun Ma, Jiao-Cen Guo, Qing-Yi Xie, Li Yang, Hao-Fu Dai, You-Geng Wu, You-Xing Zhao","doi":"10.1007/s10600-024-04413-4","DOIUrl":"10.1007/s10600-024-04413-4","url":null,"abstract":"<p>A new cyclic peptide alternarin A (<b>1</b>), along with seven known compounds, alternariol (<b>2</b>), sulfated derivative of alternariol (<b>3</b>), alternariol methyl ether (<b>4</b>), altenuene (<b>5</b>), 2,5-dimethyl-7-hydroxychromone (<b>6</b>), diaporthein A (<b>7</b>), isopterocarpolone (<b>8</b>), were isolated from the betel nut endophytic fungus <i>Alternaria</i> sp. RW-AL. The structure of <b>1</b> was elucidated by 1D and 2D NMR spectra as well as HR-ESI-MS analysis. Compounds <b>1</b>, <b>4</b>, and <b>5</b> showed definite antibacterial activities against <i>Staphylococcus aureus</i> ATCC 6538 and <i>Bacillus subtilis</i> ATCC 6633.</p>","PeriodicalId":514,"journal":{"name":"Chemistry of Natural Compounds","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2024-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141933559","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-08-06DOI: 10.1007/s10600-024-04425-0
N. Sh. Kavtaradze, M. Z. Getia
{"title":"Flavonoids with Leucopoeisis Activity from Extract of Astragalus bungeanus","authors":"N. Sh. Kavtaradze, M. Z. Getia","doi":"10.1007/s10600-024-04425-0","DOIUrl":"10.1007/s10600-024-04425-0","url":null,"abstract":"","PeriodicalId":514,"journal":{"name":"Chemistry of Natural Compounds","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2024-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142410176","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-08-06DOI: 10.1007/s10600-024-04402-7
Yang Yu, Lan Ding, Ren-Nai Yang, Liang-Ping Zha, Ju-Tao Wang, Shuang-Ying Gui
Two new phenylpropanoids, plagnans (1) and plaganoid (2), along with five known phenylpropanoids, including an enantiomeric mixture (compound 3) were isolated from the roots of Platycodon grandiflorus. Meanwhile, their structures were elucidated by analyzing the spectroscopic data, including NMR, HR-ESI-MS, ECD (ICD), and X-ray analysis. Although all isolates were evaluated for their anti-inflammatory activities, and of them exhibited moderate activities, with IC50 values of around 27.5 μM.
{"title":"Phenylpropanoids with Anti-Inflammatory Effects from the Roots of Platycodon grandiflorus","authors":"Yang Yu, Lan Ding, Ren-Nai Yang, Liang-Ping Zha, Ju-Tao Wang, Shuang-Ying Gui","doi":"10.1007/s10600-024-04402-7","DOIUrl":"10.1007/s10600-024-04402-7","url":null,"abstract":"<p>Two new phenylpropanoids, plagnans (<b>1</b>) and plaganoid (<b>2</b>), along with five known phenylpropanoids, including an enantiomeric mixture (compound <b>3</b>) were isolated from the roots of <i>Platycodon grandiflorus.</i> Meanwhile, their structures were elucidated by analyzing the spectroscopic data, including NMR, HR-ESI-MS, ECD (ICD), and X-ray analysis. Although all isolates were evaluated for their anti-inflammatory activities, and of them exhibited moderate activities, with IC<sub>50</sub> values of around 27.5 μM.</p>","PeriodicalId":514,"journal":{"name":"Chemistry of Natural Compounds","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2024-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141933485","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-08-06DOI: 10.1007/s10600-024-04418-z
C. T. Chang, W. J. Li, H. T. Li, S. L. Liu, C. Y. Chen
{"title":"Metabolites from Michelia compressa var. lanyuensis with Antioxidant Activity","authors":"C. T. Chang, W. J. Li, H. T. Li, S. L. Liu, C. Y. Chen","doi":"10.1007/s10600-024-04418-z","DOIUrl":"10.1007/s10600-024-04418-z","url":null,"abstract":"","PeriodicalId":514,"journal":{"name":"Chemistry of Natural Compounds","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2024-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141933494","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}