Objective: To compare the frequency of stroke-associated pneumonia in patients given prophylactic antibiotics versus those not given prophylactic antibiotics.Study Design: Comparative Cross-sectional study.Place and Duration of Study: The study was carried out at the Department of Internal Medicine, Combined st st Military Hospital (CMH), Peshawar, Pakistan from 1 August 2022 to 31 January 2023.Methods: We included 250 ischemic stroke patients and divided them into groups A, “Prophylactic group,” and B, “no prophylactic antibiotics group.” Patients were assessed at 7 days after admission for presence of “stroke associated pneumonia (SAP)” through clinical examination and chest X-rays. Data were analyzed using a statistical package for social sciences 22. For qualitative variables, frequency and percentages were used, whereas for quantitative data, the median (IQR) was used as the data were not normally distributed and contained outliers; using the median and IQR can be more appropriate for describing the central tendency and spread of the data compared to the mean and standard deviation.Results: In our study, the median age of the patients was 68(46-83) years. 61 (24.40%) of the patients were male while 189(75.60%) were female. The median BMI was 31 (19-44) kg/m2. Diabetes was present in 123 (49.20%) patients and 96(38.40%) had hypertension. We found that in the the “prophylactic antibiotics” group (A), 9 (7.20%) patients developed SAP, while in the “no prophylactic antibiotics” group (B) frequency of SAP was 34 (27.20%) (p< 0.001).Conclusion: Prophylactic antibiotics used in “ischemic stroke” patients provide better outcomes by reducing the incidence of “stroke-associated pneumonia”. Therefore, it should be given to all patients admitted to the hospital with ischemic CVA. How to cite this: Aslam MJ, Amir M, Sayed TM, Hashmat A, Hussain M, Fatima M.Role of Prophylactic Antibiotics in Preventing Stroke Associated Pneumonia in Patients with Ischemic Stroke. Life and Science. 2024; 5(1): 82-88. doi: http://doi.org/10.37185/LnS.1.1.465
研究目的比较使用预防性抗生素和未使用预防性抗生素的患者发生中风相关肺炎的频率：比较性横断面研究：研究地点和时间：研究于2022年8月1日至2023年1月31日在巴基斯坦白沙瓦市联合军事医院（CMH）内科进行：我们纳入了 250 名缺血性脑卒中患者，并将其分为 A 组（"预防组"）和 B 组（"无预防性抗生素组"）。入院 7 天后，通过临床检查和胸部 X 光片评估患者是否患有 "卒中相关肺炎（SAP）"。数据使用社会科学统计软件包 22 进行分析。定性变量使用频率和百分比，定量数据使用中位数（IQR），因为数据不呈正态分布，且包含异常值；与平均值和标准差相比，使用中位数和 IQR 更适合描述数据的中心倾向和分布：在我们的研究中，患者的年龄中位数为 68（46-83）岁。61（24.40%）名患者为男性，189（75.60%）名患者为女性。体重指数中位数为 31 (19-44) kg/m2。123（49.20%）名患者患有糖尿病，96（38.40%）名患者患有高血压。我们发现，在 "预防性抗生素 "组（A）中，9 名（7.20%）患者出现 SAP，而在 "无预防性抗生素 "组（B）中，SAP 的发生率为 34（27.20%）（P< 0.001）：结论：对 "缺血性卒中 "患者使用预防性抗生素可降低 "卒中相关肺炎 "的发病率，从而改善预后。因此，所有入院的缺血性脑卒中患者都应使用抗生素。如何引用此文：Aslam MJ, Amir M, Sayed TM, Hashmat A, Hussain M, Fatima M.预防性抗生素在预防缺血性中风患者中风相关肺炎中的作用。生命与科学》。2024; 5(1):82-88. doi: http://doi.org/10.37185/LnS.1.1.465
{"title":"Role of Prophylactic Antibiotics in Preventing Stroke-Associated Pneumonia in Patients with Ischemic Stroke","authors":"Muhamad Jawad Aslam, Muhammad Amir, Tahir Mukhtar Sayed, Asif Hashmat, Maryam Hussain, Minahil Fatima","doi":"10.37185/lns.1.1.465","DOIUrl":"https://doi.org/10.37185/lns.1.1.465","url":null,"abstract":"Objective: To compare the frequency of stroke-associated pneumonia in patients given prophylactic antibiotics versus those not given prophylactic antibiotics.Study Design: Comparative Cross-sectional study.Place and Duration of Study: The study was carried out at the Department of Internal Medicine, Combined st st Military Hospital (CMH), Peshawar, Pakistan from 1 August 2022 to 31 January 2023.Methods: We included 250 ischemic stroke patients and divided them into groups A, “Prophylactic group,” and B, “no prophylactic antibiotics group.” Patients were assessed at 7 days after admission for presence of “stroke associated pneumonia (SAP)” through clinical examination and chest X-rays. Data were analyzed using a statistical package for social sciences 22. For qualitative variables, frequency and percentages were used, whereas for quantitative data, the median (IQR) was used as the data were not normally distributed and contained outliers; using the median and IQR can be more appropriate for describing the central tendency and spread of the data compared to the mean and standard deviation.Results: In our study, the median age of the patients was 68(46-83) years. 61 (24.40%) of the patients were male while 189(75.60%) were female. The median BMI was 31 (19-44) kg/m2. Diabetes was present in 123 (49.20%) patients and 96(38.40%) had hypertension. We found that in the the “prophylactic antibiotics” group (A), 9 (7.20%) patients developed SAP, while in the “no prophylactic antibiotics” group (B) frequency of SAP was 34 (27.20%) (p< 0.001).Conclusion: Prophylactic antibiotics used in “ischemic stroke” patients provide better outcomes by reducing the incidence of “stroke-associated pneumonia”. Therefore, it should be given to all patients admitted to the hospital with ischemic CVA. \u0000How to cite this: Aslam MJ, Amir M, Sayed TM, Hashmat A, Hussain M, Fatima M.Role of Prophylactic Antibiotics in Preventing Stroke Associated Pneumonia in Patients with Ischemic Stroke. Life and Science. 2024; 5(1): 82-88. doi: http://doi.org/10.37185/LnS.1.1.465","PeriodicalId":516717,"journal":{"name":"Life and Science","volume":"27 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140508214","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Barkat Ullah Khan, Sidra Arshad, Faiza Ikram, Iftekhar Yousef, Inam Naizi, Muhammad Ismaeel
Objective: To determine the effect of Alpha Lipoic Acid (ALA) on blood glucose, lipid profile, and oxidative stress in streptozotocin-induced type II diabetic male Sprague Dawley rats.Study Design: Laboratory-based experimental study.Place and Duration of the Study: The study was carried out at the Physiology Research Lab, Army Medical College, Rawalpindi, Pakistan, from 20th January 2021 to 24th June 2021.Methods: Thirty Sprague Dawley (SD) rats were divided into three equal groups. Group I was given a normal standard rat diet. In Groups II and III after feeding a diet rich in fat and calories for 2 weeks, after feeding a diet rich in fat and calories for 2 weeks, a single low dose of streptozotocin was injected for Type 2 Diabetes Mellitus (T2DM) induction. Alpha Lipoic Acid 30 mg/kg body weight/day was administered intraperitoneally in Group III for 01 weeks after the development of T2DM.Results: The blood glucose, lipid profile, and serum Malondialdehyde levels were deranged in the diabetic group. After Alpha Lipoic Acid supplementation, the blood glucose levels, Serum MDA, and levels of triglycerides, cholesterol, and Low Density Lipoproteins decreased, whereas High Density Lipoproteins level were significantly raised (p <0.001) in group III as compared to the diabetic group II. Conclusion: Treatment with Alpha Lipoic Acid reduces oxidative stress and improve reduces oxidative stress and improves glycemic and lipid profiles in T2DM rats. How to cite this: khan BU, Arshad S, Ikram F, Yousef I, Naizi I, Ismaeel M. The Effects of Alpha Lipoic Acid on Oxidative Stress, Lipid Profile and Blood Glucose Levels in Type 2 Diabetic Male Sprague Dawley Rats. Life and Science. 2024; 5(1): 89-94. doi: http://doi.org/10.37185/LnS.1.1.405
目的确定α-硫辛酸（ALA）对链脲佐菌素诱导的Ⅱ型糖尿病雄性Sprague Dawley大鼠血糖、血脂和氧化应激的影响：研究地点和时间：研究于 2021 年 1 月 20 日至 2021 年 6 月 24 日在巴基斯坦拉瓦尔品第陆军医学院生理研究实验室进行：将 30 只 Sprague Dawley (SD) 大鼠分为三个等量组。第一组给大鼠喂食正常标准食物。第二组和第三组在喂食富含脂肪和热量的食物 2 周后，注射单次低剂量链脲佐菌素诱导 2 型糖尿病（T2DM）。在 T2DM 发生后的 01 周内，第三组腹腔注射 30 毫克/千克体重/天的α-硫辛酸：结果：糖尿病组的血糖、血脂和血清丙二醛水平都出现了异常。补充阿尔法硫辛酸后，与糖尿病 II 组相比，III 组的血糖水平、血清 MDA 以及甘油三酯、胆固醇和低密度脂蛋白水平均有所下降，而高密度脂蛋白水平则显著升高（p <0.001）。结论用硫辛酸治疗可降低氧化应激，改善T2DM大鼠的血糖和血脂状况。引用方式：Khan BU, Arshad S, Ikram F, Yousef I, Naizi I, Ismaeel M. The Effects of Alpha Lipoic Acid on Oxidative Stress, Lipid Profile and Blood Glucose Levels in Type 2 Diabetic Male Sprague Dawley Rats. Life and Science.生命与科学》。2024; 5(1):89-94. doi: http://doi.org/10.37185/LnS.1.1.405
{"title":"The Effects of Alpha Lipoic Acid on Oxidative Stress, Lipid Profile, and Blood Glucose Levels in Type 2 Diabetic Male Sprague Dawley Rats","authors":"Barkat Ullah Khan, Sidra Arshad, Faiza Ikram, Iftekhar Yousef, Inam Naizi, Muhammad Ismaeel","doi":"10.37185/405","DOIUrl":"https://doi.org/10.37185/405","url":null,"abstract":"Objective: To determine the effect of Alpha Lipoic Acid (ALA) on blood glucose, lipid profile, and oxidative stress in streptozotocin-induced type II diabetic male Sprague Dawley rats.Study Design: Laboratory-based experimental study.Place and Duration of the Study: The study was carried out at the Physiology Research Lab, Army Medical College, Rawalpindi, Pakistan, from 20th January 2021 to 24th June 2021.Methods: Thirty Sprague Dawley (SD) rats were divided into three equal groups. Group I was given a normal standard rat diet. In Groups II and III after feeding a diet rich in fat and calories for 2 weeks, after feeding a diet rich in fat and calories for 2 weeks, a single low dose of streptozotocin was injected for Type 2 Diabetes Mellitus (T2DM) induction. Alpha Lipoic Acid 30 mg/kg body weight/day was administered intraperitoneally in Group III for 01 weeks after the development of T2DM.Results: The blood glucose, lipid profile, and serum Malondialdehyde levels were deranged in the diabetic group. After Alpha Lipoic Acid supplementation, the blood glucose levels, Serum MDA, and levels of triglycerides, cholesterol, and Low Density Lipoproteins decreased, whereas High Density Lipoproteins level were significantly raised (p <0.001) in group III as compared to the diabetic group II. Conclusion: Treatment with Alpha Lipoic Acid reduces oxidative stress and improve reduces oxidative stress and improves glycemic and lipid profiles in T2DM rats. \u0000How to cite this: khan BU, Arshad S, Ikram F, Yousef I, Naizi I, Ismaeel M. The Effects of Alpha Lipoic Acid on Oxidative Stress, Lipid Profile and Blood Glucose Levels in Type 2 Diabetic Male Sprague Dawley Rats. Life and Science. 2024; 5(1): 89-94. doi: http://doi.org/10.37185/LnS.1.1.405","PeriodicalId":516717,"journal":{"name":"Life and Science","volume":"4 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140507954","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ghazanfar Jabbar, Mirza Sijeel Ahmed, Arsalan Sharif Malik, Shahzad Akhtar, F. Minhas, Muhammad Talha Makshoof, Zoha Shahid
Objective: To compare the effects of early and delayed feeding after elective gut anastomosis in relation to a mean number of days of audible bowel sounds.Study Design: A cross-sectional study.Place and Duration of Study: The study was conducted at the Department of Surgery, Combined Military th th Hospital (CMH), Rawalpindi, Pakistan, from 11th May 2019 to 10th November 2019.Methods: A total of 60 individuals undergoing gut anastomosis were divided into two groups. In group A, the NG tube was removed within 6 to 24 hours of surgery, and clear oral liquids (30ml/hour) were started. Oral fluids, including juices and soups on the other day after surgery, tailed by semisolid food at 3rd day, then regular food at 4 day and finally discharge at the 5 day. In group B, the NG tube was detached three to five days after the procedure, observing NG tube output <30-50cc daily. Then, patients were followed up in post-surgical wards for 48 hours. Patients were noted and informed of the time when bowel sounds were audible, the first flatus passed, and the first stool passed. Results: The mean age in group A was 40.23 ± 15.66 years, and in group B was 37.93 ± 15.23 years. Most of the patients, 31 (51.67%), were between 16 to 30 years of age. Out of 60 patients, 36 (60.0%) were males and 24 (40.0%) were females, with male to female ratio of 1.5:1. The mean number of days of audible bowel sounds in Group A (early feeding) was 1.57 ± 0.63 days while in Group B (delayed feeding) was 3.90 ± 0.76 days (p-value = 0.0001). Conclusion: This research established that the outcome of early feeding is better than the outcome of delayed feeding after elective gut anastomosis. How to cite this: Jabbar G, Ahmed MS, Malik AS, Akhtar S, Minhas FS, Makshoof MT, Shahid Z. Comparison of Early and Delayed Feeding After Elective Gut Anastomosis. Life and Science. 2024; 5(1): 101-106. doi: http://doi.org/10.37185/LnS.1.1.411
研究目的比较选择性肠道吻合术后早期和延迟喂食对平均肠鸣音天数的影响：横断面研究：研究于2019年5月11日至2019年11月10日在巴基斯坦拉瓦尔品第联合军事医院（CMH）外科进行：共有 60 名接受肠吻合术的患者被分为两组。A 组在手术后 6 至 24 小时内拔除 NG 管，并开始口服清流液（30 毫升/小时）。术后第 2 天开始口服流质食物，包括果汁和汤类，第 3 天开始进食半固体食物，第 4 天开始进食常规食物，第 5 天开始出院。在 B 组，术后三至五天拔出 NG 管，观察 NG 管每日排出量 <30-50cc。然后，在手术后病房对患者进行 48 小时的随访。记录并告知患者听到肠鸣音的时间、首次排出肠胀气的时间和首次排出粪便的时间。结果A 组患者的平均年龄为（40.23±15.66）岁，B 组患者的平均年龄为（37.93±15.23）岁。大多数患者（31 人，占 51.67%）的年龄在 16-30 岁之间。60 名患者中，男性 36 人（60.0%），女性 24 人（40.0%），男女比例为 1.5:1。A 组（早期喂养）的平均肠鸣音天数为 1.57 ± 0.63 天，而 B 组（延迟喂养）的平均肠鸣音天数为 3.90 ± 0.76 天（P 值 = 0.0001）。结论该研究证实，择期肠吻合术后早期喂养的效果优于延迟喂养。如何引用Jabbar G, Ahmed MS, Malik AS, Akhtar S, Minhas FS, Makshoof MT, Shahid Z. 《择期肠吻合术后早期喂养与延迟喂养的比较》。生命与科学2024; 5(1):101-106. DOI: http://doi.org/10.37185/LnS.1.1.411
{"title":"Comparison of Early and Delayed Feeding after Elective Gut Anastomosis","authors":"Ghazanfar Jabbar, Mirza Sijeel Ahmed, Arsalan Sharif Malik, Shahzad Akhtar, F. Minhas, Muhammad Talha Makshoof, Zoha Shahid","doi":"10.37185/lns.1.1.411","DOIUrl":"https://doi.org/10.37185/lns.1.1.411","url":null,"abstract":"Objective: To compare the effects of early and delayed feeding after elective gut anastomosis in relation to a mean number of days of audible bowel sounds.Study Design: A cross-sectional study.Place and Duration of Study: The study was conducted at the Department of Surgery, Combined Military th th Hospital (CMH), Rawalpindi, Pakistan, from 11th May 2019 to 10th November 2019.Methods: A total of 60 individuals undergoing gut anastomosis were divided into two groups. In group A, the NG tube was removed within 6 to 24 hours of surgery, and clear oral liquids (30ml/hour) were started. Oral fluids, including juices and soups on the other day after surgery, tailed by semisolid food at 3rd day, then regular food at 4 day and finally discharge at the 5 day. In group B, the NG tube was detached three to five days after the procedure, observing NG tube output <30-50cc daily. Then, patients were followed up in post-surgical wards for 48 hours. Patients were noted and informed of the time when bowel sounds were audible, the first flatus passed, and the first stool passed. Results: The mean age in group A was 40.23 ± 15.66 years, and in group B was 37.93 ± 15.23 years. Most of the patients, 31 (51.67%), were between 16 to 30 years of age. Out of 60 patients, 36 (60.0%) were males and 24 (40.0%) were females, with male to female ratio of 1.5:1. The mean number of days of audible bowel sounds in Group A (early feeding) was 1.57 ± 0.63 days while in Group B (delayed feeding) was 3.90 ± 0.76 days (p-value = 0.0001). Conclusion: This research established that the outcome of early feeding is better than the outcome of delayed feeding after elective gut anastomosis. \u0000How to cite this: Jabbar G, Ahmed MS, Malik AS, Akhtar S, Minhas FS, Makshoof MT, Shahid Z. Comparison of Early and Delayed Feeding After Elective Gut Anastomosis. Life and Science. 2024; 5(1): 101-106. doi: http://doi.org/10.37185/LnS.1.1.411","PeriodicalId":516717,"journal":{"name":"Life and Science","volume":"3 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140508626","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Farhan M Qureshi, S. Bari, Saima Masood, Masood Wazir, Sehrish Zehra, A. Khalid
Objective: To determine the knowledge and the risk perception regarding dengue fever among the educated population along with their behaviors towards prevention in the backdrop of rising cases of dengue at the national level.Study Design: Cross-sectional study.Place and Duration of Study: The study was carried out at the Departments of Electrical, Software Engineering, Computer Sciences and Geophysics of Bahria University, Karachi Campus, Pakistan, from October 2021 to March 2022.Methods: With an observational analytical study design, 333 students were recruited through convenient sampling. Data were collected using a structured questionnaire. The socio-demographic traits and general information about dengue fever spread and prevention were presented in frequencies and percentages while dengue fever knowledge, risk perception, and behavior of respondents were compared using a chi-square test with the significance level set at 0.05. Results: It was found that 79.8% of the students recognized that transmission of dengue is through mosquitoes, whereas only 17.4% identified the correct species of dengue infection. Twenty-two percent knew that dengue is a viral illness. Sixty-eight percent marked contaminated water as a mosquito breeding site, while 52.8% believed it to be trash/garbage. Eighty-nine, sixty-nine and fifty-two percent reported the use of window screens, bed nets/mesh, and insect repellents as protective measures, respectively. Fifty-seven percent of participants considered dengue a fatal illness. Eighty-eight and seventy-five percent recognized dengue as a preventable and curable disease, respectively. Conclusion: Educated participants in this study were misapprehensive that they had satisfactory knowledge, risk perception, and behavior toward dengue fever. Very few had the correct knowledge regarding transmission mode and spread and protective and preventive strategies. Information regarding transmission mode and spread, as well as protective and preventive strategies, were insufficient. How to cite this: Qureshi FM, Bari SF, Wazir SM, Wazir M, Zehra S, Khalid A. Dengue Fever Perception and Knowledge for Endemicity Control among University Students of Karachi Life and Science. 2024; 5(1): 75-82. doi: http://doi.org/10.37185/LnS.1.1.373
研究目的研究设计：横断面研究：横断面研究：研究地点和时间：2021 年 10 月至 2022 年 3 月，在巴基斯坦卡拉奇校区巴赫瑞亚大学电气、软件工程、计算机科学和地球物理学系进行：方法：采用观察分析研究设计，通过方便抽样招募了 333 名学生。采用结构化问卷收集数据。受访者的社会人口学特征、登革热传播和预防的一般信息以频率和百分比表示，登革热知识、风险认知和行为则使用卡方检验进行比较，显著性水平设定为 0.05。结果结果发现，79.8% 的学生认识到登革热是通过蚊子传播的，而只有 17.4%的学生能正确识别登革热感染的种类。22%的学生知道登革热是一种病毒性疾病。68%的学生将受污染的水标注为蚊子滋生地，52.8%的学生认为是垃圾。分别有 89%、69% 和 52%的人表示使用窗纱、蚊帐/蚊帐和驱虫剂作为保护措施。57%的参与者认为登革热是一种致命疾病。分别有 88% 和 75% 的人认为登革热是一种可预防和可治愈的疾病。结论本研究中受过教育的参与者误认为他们对登革热的知识、风险认知和行为都令人满意。只有极少数人对登革热的传播方式和传播途径以及保护和预防策略有正确的认识。有关传播方式和传播途径以及保护和预防策略的信息不足。引用方式Qureshi FM, Bari SF, Wazir SM, Wazir M, Zehra S, Khalid A. Dengue Fever Perception and Knowledge for Endemicity Control among University Students of Karachi Life and Science.2024; 5(1):75-82. doi: http://doi.org/10.37185/LnS.1.1.373
{"title":"Dengue Fever Perception and Knowledge for Endemicity Control among University Students of Karachi","authors":"Farhan M Qureshi, S. Bari, Saima Masood, Masood Wazir, Sehrish Zehra, A. Khalid","doi":"10.37185/lns.1.1.373","DOIUrl":"https://doi.org/10.37185/lns.1.1.373","url":null,"abstract":"Objective: To determine the knowledge and the risk perception regarding dengue fever among the educated population along with their behaviors towards prevention in the backdrop of rising cases of dengue at the national level.Study Design: Cross-sectional study.Place and Duration of Study: The study was carried out at the Departments of Electrical, Software Engineering, Computer Sciences and Geophysics of Bahria University, Karachi Campus, Pakistan, from October 2021 to March 2022.Methods: With an observational analytical study design, 333 students were recruited through convenient sampling. Data were collected using a structured questionnaire. The socio-demographic traits and general information about dengue fever spread and prevention were presented in frequencies and percentages while dengue fever knowledge, risk perception, and behavior of respondents were compared using a chi-square test with the significance level set at 0.05. Results: It was found that 79.8% of the students recognized that transmission of dengue is through mosquitoes, whereas only 17.4% identified the correct species of dengue infection. Twenty-two percent knew that dengue is a viral illness. Sixty-eight percent marked contaminated water as a mosquito breeding site, while 52.8% believed it to be trash/garbage. Eighty-nine, sixty-nine and fifty-two percent reported the use of window screens, bed nets/mesh, and insect repellents as protective measures, respectively. Fifty-seven percent of participants considered dengue a fatal illness. Eighty-eight and seventy-five percent recognized dengue as a preventable and curable disease, respectively. Conclusion: Educated participants in this study were misapprehensive that they had satisfactory knowledge, risk perception, and behavior toward dengue fever. Very few had the correct knowledge regarding transmission mode and spread and protective and preventive strategies. Information regarding transmission mode and spread, as well as protective and preventive strategies, were insufficient. \u0000How to cite this: Qureshi FM, Bari SF, Wazir SM, Wazir M, Zehra S, Khalid A. Dengue Fever Perception and Knowledge for Endemicity Control among University Students of Karachi Life and Science. 2024; 5(1): 75-82. doi: http://doi.org/10.37185/LnS.1.1.373","PeriodicalId":516717,"journal":{"name":"Life and Science","volume":"51 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140507730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective: To determine the occurrence of restless leg syndrome in individuals with non-dialysis-dependent chronic kidney disease.Study Design: A descriptive cross-sectional study.Place and Duration of Study: The study was carried out at the Outpatient Department (OPD) of Fatima Memorial Hospital, Lahore, Pakistan, from March 2020 to August 2020.Methods: A total of 280 CKD patients not dependent on dialysis were included in the study. The data were collected through interviews containing questions from international restless leg syndrome study group (IRLSSG). Patients were stratified into different stages according to the estimated glomerular filtration rate (eGFR). Restless leg syndrome was diagnosed by analyzing the responses of the interview marked by the examiner. Results: Among 280 patients, 15.7% (n=44) of chronic kidney disease patients were noted to have restless leg syndrome. The syndrome was significantly more frequent in females and was associated with higher CKD stages (Stage V > Stage III and IV). There was no association with either age or BMI.Conclusion: Restless leg syndrome is more common in chronic kidney disease stage V as compared to lower chronic kidney disease stages (III & IV). If untreated, it can affect patients' quality of life and increase the risk of cardiovascular activities. How to cite this: Basit MB, Sabir O, Shahid AH, Kanwal A, Qadri GA, Rizvi N. Evaluation of Restless Leg Syndrome in Patients with NonDialysis Dependent Chronic Kidney Disease at Fatima Memorial Hospital Lahore: A Cross-sectional study. Life and Science. 2024; 5(1): 95-100.doi: http://doi.org/10.37185/LnS.1.1.516
研究目的研究设计：一项描述性横断面研究：描述性横断面研究：研究地点和时间：研究于 2020 年 3 月至 2020 年 8 月在巴基斯坦拉合尔法蒂玛纪念医院门诊部（OPD）进行：研究共纳入 280 名不依赖透析的慢性肾脏病患者。数据是通过访谈收集的，访谈内容包括国际不安腿综合征研究小组（IRLSSG）提出的问题。根据估计肾小球滤过率（eGFR）将患者分为不同阶段。通过分析检查员标记的访谈回答，诊断出不安腿综合征。结果在 280 名患者中，15.7% 的慢性肾病患者（n=44）患有不安腿综合征。该综合征明显多见于女性，且与较高的慢性肾脏病分期有关（第五期>第三期和第四期）。结论：结论：与较低的慢性肾脏病分期（III 期和 IV 期）相比，不宁腿综合征在慢性肾脏病 V 期更为常见。如果不及时治疗，会影响患者的生活质量，并增加心血管活动的风险。引用方式Basit MB, Sabir O, Shahid AH, Kanwal A, Qadri GA, Rizvi N. Evaluation of Restless Leg Syndrome in Patients with NonDialysis Dependent Chronic Kidney Disease at Fatima Memorial Hospital Lahore：横断面研究。生命与科学》。2024; 5(1):95-100.doi: http://doi.org/10.37185/LnS.1.1.516
{"title":"Evaluation of Restless Leg Syndrome in Patients with Non-Dialysis Dependent Chronic Kidney Disease at Fatima Memorial Hospital Lahore: A Cross-sectional Study","authors":"Bilal Basit, Omer Sabir, Adnan Hussain Shahid, Andleeb Kanwal, Ghulam Abass Qadri, Nabiha Rizvi","doi":"10.37185/lns.1.1.516","DOIUrl":"https://doi.org/10.37185/lns.1.1.516","url":null,"abstract":"Objective: To determine the occurrence of restless leg syndrome in individuals with non-dialysis-dependent chronic kidney disease.Study Design: A descriptive cross-sectional study.Place and Duration of Study: The study was carried out at the Outpatient Department (OPD) of Fatima Memorial Hospital, Lahore, Pakistan, from March 2020 to August 2020.Methods: A total of 280 CKD patients not dependent on dialysis were included in the study. The data were collected through interviews containing questions from international restless leg syndrome study group (IRLSSG). Patients were stratified into different stages according to the estimated glomerular filtration rate (eGFR). Restless leg syndrome was diagnosed by analyzing the responses of the interview marked by the examiner. Results: Among 280 patients, 15.7% (n=44) of chronic kidney disease patients were noted to have restless leg syndrome. The syndrome was significantly more frequent in females and was associated with higher CKD stages (Stage V > Stage III and IV). There was no association with either age or BMI.Conclusion: Restless leg syndrome is more common in chronic kidney disease stage V as compared to lower chronic kidney disease stages (III & IV). If untreated, it can affect patients' quality of life and increase the risk of cardiovascular activities. \u0000How to cite this: Basit MB, Sabir O, Shahid AH, Kanwal A, Qadri GA, Rizvi N. Evaluation of Restless Leg Syndrome in Patients with NonDialysis Dependent Chronic Kidney Disease at Fatima Memorial Hospital Lahore: A Cross-sectional study. Life and Science. 2024; 5(1): 95-100.doi: http://doi.org/10.37185/LnS.1.1.516","PeriodicalId":516717,"journal":{"name":"Life and Science","volume":"95 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140507803","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective: To determine the diagnostic accuracy of serum Cystatin C for early detection of kidney damage taking albumin Creatinine Ratio as a reference standard among people of Bahawalpur having diabetes mellitus type 2.Study Design: A cross-sectional study.Place and Duration of Study: The Study was conducted at the Department of Pathology in collaboration with th th Kidney Center, Bahawalpur Victoria Hospital, Bahawalpur, Pakistan from 27 August 2021 to 26 February 2022.Methods: There was a total of 200 patients having diabetes mellitus type 2 with GFR between 60-90ml/min with an age range from 40-60 years were selected. Study participants with a history of steroid intake, hypothyroidism, chronic liver disease, AIDS, and hypertension were not included in the study. For assessment of diagnostic accuracy of Cystatin C to evaluate the renal damages in early stages, microalbuminuria was evaluated. As per the guidelines provided by the respective manufacturers, individuals exhibiting two albumin creatinine ratio (ACR) levels exceeding 30 mg/g were classified as having diabetic nephropathy (DN).Results: The overall sensitivity, specificity, positive predictive value, negative predictive value, and diagnostic accuracy of serum Cystatin C for the early detection of kidney damage, with albumin-to-creatinine ratio used as the reference standard among individuals with type 2 diabetes mellitus, were 90.98%, 78.21%, 86.72%, 84.72%, and 86.0%, respectively.Conclusion: The findings of this investigation indicate that serum cystatin C (CysC) exhibits a considerable level of diagnostic accuracy in the early detection of kidney damage among individuals with type 2 diabetes mellitus, utilizing the albumin-to-creatinine ratio as a reference standard.How to cite this: Sajid I, Saeed R, Goheer A, Asghar S, Saqib S, Bashir F. Diagnostic Accuracy of Serum Cystatin C for Early Detection of Kidney Damage in Patients with Type II Diabetes Mellitus: Bahawalpur, Pakistan. Life and Science. 2024; 5(1): 41-47. doi: http://doi.org/10.37185/LnS.1.1.559
目的以白蛋白肌酐比值为参考标准，确定血清胱抑素 C 对早期检测巴哈瓦尔布尔 2 型糖尿病患者肾脏损伤的诊断准确性：横断面研究：研究地点和时间：研究于2021年8月27日至2022年2月26日在巴基斯坦巴哈瓦尔布尔维多利亚医院病理科与肾脏中心合作进行：方法：共选取了 200 名 GFR 在 60-90 毫升/分钟之间、年龄在 40-60 岁之间的 2 型糖尿病患者。有类固醇摄入史、甲状腺功能减退症、慢性肝病、艾滋病和高血压的患者不在研究范围内。为评估胱抑素 C 对早期肾损害的诊断准确性，对微量白蛋白尿进行了评估。根据各生产商提供的指南，两次白蛋白肌酐比值（ACR）超过 30 毫克/克的个体被归类为糖尿病肾病（DN）：结果：以白蛋白与肌酐比值作为参考标准，血清胱抑素 C 早期检测 2 型糖尿病患者肾脏损害的总体敏感性、特异性、阳性预测值、阴性预测值和诊断准确性分别为 90.98%、78.21%、86.72%、84.72% 和 86.0%：本研究结果表明，以白蛋白-肌酐比值作为参考标准，血清胱抑素C（CysC）在早期检测2型糖尿病患者肾脏损伤方面具有相当高的诊断准确性：Sajid I, Saeed R, Goheer A, Asghar S, Saqib S, Bashir F. 《血清胱抑素 C 早期检测 II 型糖尿病患者肾损伤的诊断准确性》：巴基斯坦巴哈瓦尔布尔。生命与科学》。2024; 5(1):41-47. DOI: http://doi.org/10.37185/LnS.1.1.559
{"title":"Diagnostic Accuracy of Serum Cystatin C for Early Detection of Kidney Damage in Patients with Type II Diabetes Mellitus: Bahawalpur, Pakistan","authors":"Iqra Sajid, Rabia Saeed, Arfa Goheer, Sameen Asghar, Sara Saqib, Fareeha Bashir","doi":"10.37185/lns.1.1.559","DOIUrl":"https://doi.org/10.37185/lns.1.1.559","url":null,"abstract":"Objective: To determine the diagnostic accuracy of serum Cystatin C for early detection of kidney damage taking albumin Creatinine Ratio as a reference standard among people of Bahawalpur having diabetes mellitus type 2.Study Design: A cross-sectional study.Place and Duration of Study: The Study was conducted at the Department of Pathology in collaboration with th th Kidney Center, Bahawalpur Victoria Hospital, Bahawalpur, Pakistan from 27 August 2021 to 26 February 2022.Methods: There was a total of 200 patients having diabetes mellitus type 2 with GFR between 60-90ml/min with an age range from 40-60 years were selected. Study participants with a history of steroid intake, hypothyroidism, chronic liver disease, AIDS, and hypertension were not included in the study. For assessment of diagnostic accuracy of Cystatin C to evaluate the renal damages in early stages, microalbuminuria was evaluated. As per the guidelines provided by the respective manufacturers, individuals exhibiting two albumin creatinine ratio (ACR) levels exceeding 30 mg/g were classified as having diabetic nephropathy (DN).Results: The overall sensitivity, specificity, positive predictive value, negative predictive value, and diagnostic accuracy of serum Cystatin C for the early detection of kidney damage, with albumin-to-creatinine ratio used as the reference standard among individuals with type 2 diabetes mellitus, were 90.98%, 78.21%, 86.72%, 84.72%, and 86.0%, respectively.Conclusion: The findings of this investigation indicate that serum cystatin C (CysC) exhibits a considerable level of diagnostic accuracy in the early detection of kidney damage among individuals with type 2 diabetes mellitus, utilizing the albumin-to-creatinine ratio as a reference standard.How to cite this: Sajid I, Saeed R, Goheer A, Asghar S, Saqib S, Bashir F. Diagnostic Accuracy of Serum Cystatin C for Early Detection of Kidney Damage in Patients with Type II Diabetes Mellitus: Bahawalpur, Pakistan. Life and Science. 2024; 5(1): 41-47. doi: http://doi.org/10.37185/LnS.1.1.559","PeriodicalId":516717,"journal":{"name":"Life and Science","volume":"50 3-4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140507832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Haseeb Noor, Kazim Abbas Virk, Hyder Wajid Abbasi, S. Virk, Sara Shahid, Muhammad Erfan
Objective: To compare a first-line Clarithromycin-based triple therapy to Levofloxacin-based triple therapy for eradicating H.Pylori.Study Design: Comparative analysis.Place and Duration of Study: The study was carried out at the Department of the Gastroenterology of Pakistan Institute of Medical Sciences (PIMS), Islamabad, Pakistan, from June 2021 to December 2021.Methods: A total of 200 patients were enrolled in this comparative study, conducted in the outpatient Department of Gastroenterology. A pretested questionnaire was used to gather the required information; a group was allocated to each patient, and a response was sent to each treatment group after random sampling. The primary outcome was a negative Urea Breath test 4 weeks after completion of treatment. Results: Out of 200 patients, 58 % (n=116) were males, and 39% (n= 84) were females. The mean age was 40.02 ± 24.4 years. Predominant presenting complaints were Retrosternal burning in 41 % (n=82), and pain and/or discomfort in the upper abdomen 34% (n=68). The response rate in the Clarithromycin based therapy group was 84% (n=84) out of 100 patients, while the response rate was 94% (n= 94) out of 100 in the Levofloxacin-based therapy group. Conclusion: Levofloxacin-based therapy is superior to Clarithromycin-based therapy in every age group and gender.How to cite this: Noor H, Virk KA, Abbasi HW, Virk ST, Shahid S, Erfan M. The Efficacy of Levofloxacin Based Triple Therapy over Standard Clarithromycin Based Therapy for Eradication of Helicobacter Pylori. Life and Science. 2024; 5(1): 61-67. doi: http://doi.org/10.37185/LnS.1.1.462
研究目的比较以克拉霉素为基础的一线三联疗法和以左氧氟沙星为基础的三联疗法在根除幽门螺杆菌方面的疗效：比较分析：研究地点和时间：研究于2021年6月至2021年12月在巴基斯坦伊斯兰堡的巴基斯坦医学科学研究所（PIMS）消化内科进行：这项比较研究在消化内科门诊部进行，共招募了 200 名患者。研究使用了一份预先测试过的调查问卷来收集所需信息；为每位患者分配了一个治疗组，并在随机抽样后向每个治疗组发出了答复。主要结果是治疗结束 4 周后尿素呼气试验呈阴性。结果显示在 200 名患者中，58%（n=116）为男性，39%（n=84）为女性。平均年龄为 40.02±24.4 岁。主要主诉为胸骨后烧灼感占 41%（82 人），上腹部疼痛和/或不适占 34%（68 人）。在 100 名患者中，克拉霉素治疗组的应答率为 84%（n=84），而左氧氟沙星治疗组的应答率为 94%（n=94）。结论在各个年龄组和性别中，以左氧氟沙星为基础的疗法都优于以克拉霉素为基础的疗法：Noor H, Virk KA, Abbasi HW, Virk ST, Shahid S, Erfan M. The Efficacy of Levofloxacin-based Triple Therapy over Standard Clarithromycin Based Therapy for Eradication of Helicobacter Pylori.生命与科学》。2024; 5(1):61-67. doi: http://doi.org/10.37185/LnS.1.1.462
{"title":"The Efficacy of Levofloxacin-Based Triple Therapy over Standard ClarithromycinBased Therapy for Eradication of Helicobacter Pylori","authors":"Haseeb Noor, Kazim Abbas Virk, Hyder Wajid Abbasi, S. Virk, Sara Shahid, Muhammad Erfan","doi":"10.37185/lns.1.1.462","DOIUrl":"https://doi.org/10.37185/lns.1.1.462","url":null,"abstract":"Objective: To compare a first-line Clarithromycin-based triple therapy to Levofloxacin-based triple therapy for eradicating H.Pylori.Study Design: Comparative analysis.Place and Duration of Study: The study was carried out at the Department of the Gastroenterology of Pakistan Institute of Medical Sciences (PIMS), Islamabad, Pakistan, from June 2021 to December 2021.Methods: A total of 200 patients were enrolled in this comparative study, conducted in the outpatient Department of Gastroenterology. A pretested questionnaire was used to gather the required information; a group was allocated to each patient, and a response was sent to each treatment group after random sampling. The primary outcome was a negative Urea Breath test 4 weeks after completion of treatment. Results: Out of 200 patients, 58 % (n=116) were males, and 39% (n= 84) were females. The mean age was 40.02 ± 24.4 years. Predominant presenting complaints were Retrosternal burning in 41 % (n=82), and pain and/or discomfort in the upper abdomen 34% (n=68). The response rate in the Clarithromycin based therapy group was 84% (n=84) out of 100 patients, while the response rate was 94% (n= 94) out of 100 in the Levofloxacin-based therapy group. Conclusion: Levofloxacin-based therapy is superior to Clarithromycin-based therapy in every age group and gender.How to cite this: Noor H, Virk KA, Abbasi HW, Virk ST, Shahid S, Erfan M. The Efficacy of Levofloxacin Based Triple Therapy over Standard Clarithromycin Based Therapy for Eradication of Helicobacter Pylori. Life and Science. 2024; 5(1): 61-67. doi: http://doi.org/10.37185/LnS.1.1.462","PeriodicalId":516717,"journal":{"name":"Life and Science","volume":"21 3-4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140507710","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sahrish Mukhtar, Nuzhat Hassan, M. Lakhani, Urooj Fatima, S. Shaheen, Iffat Raza
Objective: This study aimed to evaluate retinal nerve fiber layer (RNFL) thickness in healthy individuals with myopic and hypermetropic eyes, using optical coherence tomography (OCT).Study Design: A cross-sectional study. Place and Duration of Study: The study was carried out at the Department of Ophthalmology, Dr. Akil bin Abdul Qadir Institute of Ophthalmology, Karachi, Pakistan from January 2015 to June 2015.Methods: In this study, 300 eyes were included were examined using standard protocols by a single examiner. Subjects with a history of diabetic or hypertensive retinopathy, raised intraocular pressure (> 21mmHg), and previous intraocular or laser surgery were excluded from the study. The mean retinal nerve fiber layer thickness was calculated in both myopic and hypermetropic eyes. Results: The mean global retinal nerve fiber layer thickness (RNFLT) in myopic eyes was found to be 93.98 ± 8.57 μm. In hypermetropic eyes, it was found to be 101.00 ± 6.58. This variation was found to be statistically significant with p-value of 0.001.Conclusion: We concluded that individuals with myopic eyes had significantly reduced retinal nerve fiber layer thickness whereas those with hypermetropic eyes showed an insignificant increase in RNFLT compared to emmetropic eyes.How to cite this: Mukhtar S, Hassan N, Lakhani M, Fatima U, Shaheen S, Raza I. Retinal Nerve Fiber Layer Thickness (RNFLT) in Myopic & Hypermetropic Eyes in a Subset of Pakistani Population. Life and Science. 2024; 5(1): 54-60. doi: http://doi.org/10.37185/LnS.1.1.480
研究目的本研究旨在使用光学相干断层扫描（OCT）评估健康近视眼和高度近视眼患者的视网膜神经纤维层（RNFL）厚度：横断面研究。研究地点和时间：研究于 2015 年 1 月至 2015 年 6 月在巴基斯坦卡拉奇阿基勒-本-阿卜杜勒-卡迪尔博士眼科研究所眼科部进行：本研究共纳入 300 只眼睛，由一名检查员采用标准方案进行检查。有糖尿病或高血压视网膜病变病史、眼压升高（> 21mmHg）以及曾做过眼内手术或激光手术的受试者不在研究范围内。计算近视眼和高度屈光不正眼的平均视网膜神经纤维层厚度。结果显示近视眼的平均视网膜神经纤维层厚度（RNFLT）为 93.98 ± 8.57 μm。在高度近视眼中，平均值为 101.00 ± 6.58。这一差异具有统计学意义，P 值为 0.001：结论：我们得出结论，近视眼患者的视网膜神经纤维层厚度明显减少，而与弱视眼相比，高度近视眼患者的视网膜神经纤维层厚度增加不明显：Mukhtar S, Hassan N, Lakhani M, Fatima U, Shaheen S, Raza I. 巴基斯坦人群近视眼和远视眼的视网膜神经纤维层厚度（RNFLT）。生命与科学2024; 5(1):54-60. DOI: http://doi.org/10.37185/LnS.1.1.480
{"title":"Retinal Nerve Fiber Layer Thickness (RNFLT) in Myopic & Hypermetropic Eyes in a Subset of Pakistani Population","authors":"Sahrish Mukhtar, Nuzhat Hassan, M. Lakhani, Urooj Fatima, S. Shaheen, Iffat Raza","doi":"10.37185/lns.1.1.480","DOIUrl":"https://doi.org/10.37185/lns.1.1.480","url":null,"abstract":"Objective: This study aimed to evaluate retinal nerve fiber layer (RNFL) thickness in healthy individuals with myopic and hypermetropic eyes, using optical coherence tomography (OCT).Study Design: A cross-sectional study. Place and Duration of Study: The study was carried out at the Department of Ophthalmology, Dr. Akil bin Abdul Qadir Institute of Ophthalmology, Karachi, Pakistan from January 2015 to June 2015.Methods: In this study, 300 eyes were included were examined using standard protocols by a single examiner. Subjects with a history of diabetic or hypertensive retinopathy, raised intraocular pressure (> 21mmHg), and previous intraocular or laser surgery were excluded from the study. The mean retinal nerve fiber layer thickness was calculated in both myopic and hypermetropic eyes. Results: The mean global retinal nerve fiber layer thickness (RNFLT) in myopic eyes was found to be 93.98 ± 8.57 μm. In hypermetropic eyes, it was found to be 101.00 ± 6.58. This variation was found to be statistically significant with p-value of 0.001.Conclusion: We concluded that individuals with myopic eyes had significantly reduced retinal nerve fiber layer thickness whereas those with hypermetropic eyes showed an insignificant increase in RNFLT compared to emmetropic eyes.How to cite this: Mukhtar S, Hassan N, Lakhani M, Fatima U, Shaheen S, Raza I. Retinal Nerve Fiber Layer Thickness (RNFLT) in Myopic & Hypermetropic Eyes in a Subset of Pakistani Population. Life and Science. 2024; 5(1): 54-60. doi: http://doi.org/10.37185/LnS.1.1.480","PeriodicalId":516717,"journal":{"name":"Life and Science","volume":" 18","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139640592","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective: To evaluate the correlation of low borderline amniotic fluid index and oligohydramnios with perinatal outcomes among pregnant females presenting at the tertiary care hospital of Karachi. Study Design: Cross-sectional study.Place and Duration of Study: The study was conducted at the Department of Obstetrics and Gynecology, Hamdard University, Karachi, Pakistan, from March 2021 to March 2022.Methods: Females aged 18-45 years, with a gestational age of 20-42 weeks assessed on the last menstrual period and a single fetus on ultrasound were enrolled. The final sample size for the study was determined to be 260 with 130 participants in each group, i.e., the females with Amniotic Fluid Value (AFI) value of ≤5 cm considered as oligohydramnios (group-1) and AFI value of 5.1 to 8 cm considered as borderline AFI (group-2)The amniotic fluid index value was determined in all the females using ultrasonographic reports by the consultant physicians. Females were classified as having oligohydramnios if their amniotic fluid index value was less than 5 cm and borderline amniotic fluid index between 5.1 and 8 cm. To evaluate the maternal and perinatal outcomes, all females were monitored up to birth. Data was analyzed using SPSS version 23.Results: The mean maternal age was 29.85±5.45 years, and the mean BMI was 29.78±5.62 kg/m . Most of the females had gravida ≥1. Females with oligohydramnios had higher rates of low birth weight (84.6% vs. 51.5%, p=0.001), IUGR (68.5% vs. 22.3%, p=0.001), meconium staining (42.3% vs 7.7%, p=0.001), low APGAR score (50.8% vs. 13.8%, p=0.001), respiratory distress syndrome (72.3% vs 27.7%, p=0.001), birth asphyxia (65.4% vs 23.1%, p=0.001), NICU admission (73.8% vs. 43.1%, p=0.001), and neonatal death (21.5% vs. 5.4%, p=0.001) than women with borderline amniotic fluid index.Conclusion: This observational study demonstrates a significant correlation between oligohydramnios and adverse perinatal outcomes, emphasizing the importance of vigilant monitoring and intervention in pregnancies with low amniotic fluid. How to cite this: Jamsheed S, Abid K. Clinical and Sonological Evaluation of Borderline Amniotic Fluid Index and Oligohydramnios-Its Correlation with Perinatal Outcomes. Life and Science. 2024; 5(1): 16-21. doi: http://doi.org/10.37185/LnS.1.1.378
目的评估在卡拉奇三级医院就诊的孕妇中，低边界羊水指数和少水羊膜症与围产期结局的相关性。研究设计横断面研究：研究于 2021 年 3 月至 2022 年 3 月在巴基斯坦卡拉奇哈姆达德大学妇产科进行：研究对象为年龄在 18-45 岁之间、孕龄为 20-42 周（根据末次月经评估）、超声检查显示为单胎的女性。研究的最终样本量确定为 260 人，每组 130 人，即羊水指数（AFI）值≤5 厘米的女性为少羊水（第 1 组），羊水指数值为 5.1 至 8 厘米的女性为边缘羊水（第 2 组）。所有女性的羊水指数值均由顾问医生通过超声波报告确定。如果羊水指数值小于 5 厘米，则被归类为少水羊膜症；如果羊水指数值在 5.1 厘米至 8 厘米之间，则被归类为边缘羊水指数症。为了评估产妇和围产期的结果，所有女性都接受了直至分娩的监测。数据使用 SPSS 23 版进行分析：产妇的平均年龄为（29.85±5.45）岁，平均体重指数为（29.78±5.62）kg/m。低血钙产妇的低出生体重率（84.6% vs. 51.5%，P=0.001）、IUGR（68.5% vs. 22.3%，P=0.001）、胎粪染色（42.3% vs. 7.7%，P=0.001）、低 APGAR 评分（50.8% vs. 13.8%，P=0.001）、呼吸窘迫综合征（72.3% vs. 27.7%，p=0.001）、出生窒息（65.4% vs. 23.1%，p=0.001）、入住新生儿重症监护室（73.8% vs. 43.1%，p=0.001）和新生儿死亡（21.5% vs. 5.4%，p=0.001）：这项观察性研究表明，羊水过少与围产期不良结局之间存在显著相关性，强调了对羊水过少孕妇进行警惕性监测和干预的重要性。如何引用：Jamsheed S, Abid K. 边界羊水指数和羊水过少的临床和声学评估--与围产期结局的相关性。生命与科学》。2024; 5(1):16-21. DOI: http://doi.org/10.37185/LnS.1.1.378
{"title":"Clinical and Sonological Evaluation of Borderline Amniotic Fluid Index and Oligohydramnios-Its Correlation with Perinatal Outcomes","authors":"Saira Jamsheed, Khadijah Abid","doi":"10.37185/lns.1.1.378","DOIUrl":"https://doi.org/10.37185/lns.1.1.378","url":null,"abstract":"Objective: To evaluate the correlation of low borderline amniotic fluid index and oligohydramnios with perinatal outcomes among pregnant females presenting at the tertiary care hospital of Karachi. Study Design: Cross-sectional study.Place and Duration of Study: The study was conducted at the Department of Obstetrics and Gynecology, Hamdard University, Karachi, Pakistan, from March 2021 to March 2022.Methods: Females aged 18-45 years, with a gestational age of 20-42 weeks assessed on the last menstrual period and a single fetus on ultrasound were enrolled. The final sample size for the study was determined to be 260 with 130 participants in each group, i.e., the females with Amniotic Fluid Value (AFI) value of ≤5 cm considered as oligohydramnios (group-1) and AFI value of 5.1 to 8 cm considered as borderline AFI (group-2)The amniotic fluid index value was determined in all the females using ultrasonographic reports by the consultant physicians. Females were classified as having oligohydramnios if their amniotic fluid index value was less than 5 cm and borderline amniotic fluid index between 5.1 and 8 cm. To evaluate the maternal and perinatal outcomes, all females were monitored up to birth. Data was analyzed using SPSS version 23.Results: The mean maternal age was 29.85±5.45 years, and the mean BMI was 29.78±5.62 kg/m . Most of the females had gravida ≥1. Females with oligohydramnios had higher rates of low birth weight (84.6% vs. 51.5%, p=0.001), IUGR (68.5% vs. 22.3%, p=0.001), meconium staining (42.3% vs 7.7%, p=0.001), low APGAR score (50.8% vs. 13.8%, p=0.001), respiratory distress syndrome (72.3% vs 27.7%, p=0.001), birth asphyxia (65.4% vs 23.1%, p=0.001), NICU admission (73.8% vs. 43.1%, p=0.001), and neonatal death (21.5% vs. 5.4%, p=0.001) than women with borderline amniotic fluid index.Conclusion: This observational study demonstrates a significant correlation between oligohydramnios and adverse perinatal outcomes, emphasizing the importance of vigilant monitoring and intervention in pregnancies with low amniotic fluid. How to cite this: Jamsheed S, Abid K. Clinical and Sonological Evaluation of Borderline Amniotic Fluid Index and Oligohydramnios-Its Correlation with Perinatal Outcomes. Life and Science. 2024; 5(1): 16-21. doi: http://doi.org/10.37185/LnS.1.1.378","PeriodicalId":516717,"journal":{"name":"Life and Science","volume":"14 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140506612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. Shahid, Huma Beenish, Tooba Khurshid, Amber Rashid, Uzma Shahid, Maimoona Khan
Objective: To determine the protective effect of vitamin D on the articular cartilage of formalin-induced arthritis in rats.Study Design: Lab–based Experimental study.Place and Duration of Study: The study was carried out at the Department of Anatomy, Islamic International Medical College from September 2020 to September 2021.Methods: We randomly split thirty adult male albino rats weighing between 250 and 300 grams into three groups. (10 in total). On days 1 and 3 of the experiment, formaldehyde was subcutaneously injected into the right paw of every animal, with the exception of those in group A. The usual rat food was given to the rats in Groups A and B. Throughout the trial, Rats in group C were given vitamin D 4000IU/kg orally by adding cholecalciferol (Vitamin D3) injection in a standard diet for 28 days. All of the animals were dissected after the experiment, and the right hind leg was taken out, processed, and stained with H&E for a microscopic assessment of the thickness of the unclarified cartilage. Version 21 of SPSS was used to analyze the results.Results: The oral administration of vitamin D exhibited a significant increase in unclarified cartilage thickness on intergroup comparison.Conclusion: Vitamin D is an effective antiarthritic agent in ameliorating the thickness of articular cartilage thickness in arthritic rat models. How to cite this: Shahid A, Beenish H, Khurshid T, Rashid A, Shahid U, Khan M. Ameliorative Effect of Vitamin D on Articular Cartilage Thickness in Arthritic Rat Model. Life and Science. 2024; 5(1): 107-112. doi: http://doi.org/10.37185/LnS.1.1.570
研究目的确定维生素 D 对福尔马林诱导的大鼠关节炎关节软骨的保护作用：实验室实验研究：研究于2020年9月至2021年9月在伊斯兰国际医学院解剖学系进行：我们将 30 只体重在 250 至 300 克之间的成年雄性白化大鼠随机分成三组（共 10 只）。(共 10 只）。在实验的第 1 天和第 3 天，除 A 组大鼠外，每只大鼠的右爪均皮下注射甲醛。A 组和 B 组大鼠食用普通大鼠食物。在整个实验期间，C 组大鼠通过在标准饮食中添加胆钙化醇（维生素 D3）注射液，口服维生素 D 4000IU/kg，持续 28 天。实验结束后解剖所有动物，取出右后腿，处理后用 H&E 染色，以显微镜评估未硬化软骨的厚度。使用 SPSS 21 版对结果进行分析：结果：在组间比较中，口服维生素 D 能显著增加未硬化软骨的厚度：维生素D是一种有效的抗关节炎药物，可改善关节炎大鼠模型的关节软骨厚度。引用方式Shahid A, Beenish H, Khurshid T, Rashid A, Shahid U, Khan M. Ameliorative Effect of Vitamin D on Articular Cartilage Thickness in Arthritic Rat Model.生命与科学2024; 5(1):107-112. DOI: http://doi.org/10.37185/LnS.1.1.570
{"title":"Ameliorative Effect of Vitamin D on Articular Cartilage Thickness in Arthritic Rat Model","authors":"A. Shahid, Huma Beenish, Tooba Khurshid, Amber Rashid, Uzma Shahid, Maimoona Khan","doi":"10.37185/lns.1.1.570","DOIUrl":"https://doi.org/10.37185/lns.1.1.570","url":null,"abstract":"Objective: To determine the protective effect of vitamin D on the articular cartilage of formalin-induced arthritis in rats.Study Design: Lab–based Experimental study.Place and Duration of Study: The study was carried out at the Department of Anatomy, Islamic International Medical College from September 2020 to September 2021.Methods: We randomly split thirty adult male albino rats weighing between 250 and 300 grams into three groups. (10 in total). On days 1 and 3 of the experiment, formaldehyde was subcutaneously injected into the right paw of every animal, with the exception of those in group A. The usual rat food was given to the rats in Groups A and B. Throughout the trial, Rats in group C were given vitamin D 4000IU/kg orally by adding cholecalciferol (Vitamin D3) injection in a standard diet for 28 days. All of the animals were dissected after the experiment, and the right hind leg was taken out, processed, and stained with H&E for a microscopic assessment of the thickness of the unclarified cartilage. Version 21 of SPSS was used to analyze the results.Results: The oral administration of vitamin D exhibited a significant increase in unclarified cartilage thickness on intergroup comparison.Conclusion: Vitamin D is an effective antiarthritic agent in ameliorating the thickness of articular cartilage thickness in arthritic rat models. \u0000How to cite this: Shahid A, Beenish H, Khurshid T, Rashid A, Shahid U, Khan M. Ameliorative Effect of Vitamin D on Articular Cartilage Thickness in Arthritic Rat Model. Life and Science. 2024; 5(1): 107-112. doi: http://doi.org/10.37185/LnS.1.1.570","PeriodicalId":516717,"journal":{"name":"Life and Science","volume":"17 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140508023","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
京公网安备 11010802042870号
京ICP备2023020795号-1
扫码关注我们
求助内容：
应助结果提醒方式：