Muhammad Ayaz, Sayed Ali Zeeshan Kausar, Muhammad Alamgir, Shafiq Muhammad, Fayaz Muhammad Khan, Sami Ullah
Objective: To compare the efficacy of ciprofloxacin and co-trimoxazole in urinary tract infection due to Escherichia Coli.Study Design: A cross- sectional study. Place and Duration of Study: This study was conducted at the Department of Medicine, Muhammad TeachingHospital (MTH), Peshawar, Pakistan from 1 July 2022 to 31 December 2022.Methods: Patients were randomly and consecutively assigned to either group by using lottery method (double blind). A total of 194 patients diagnosed with urinary tract infection due to E coli were randomly divided into two groups, 97 patients in each group, using 54% efficacy of ciprofloxacin, 74% efficacy of Co-Trimoxazole, 95% confidence level, and 90% power of test, using WHO software. “Group-A' for Ciprofloxacin 500mg BD and th 'Group-B' for Co-Trimoxazole 960mg BD. All the recruited patients were followed up after the 48 hour of their treatment and results were recorded. The chi-Square test was applied to compare the efficacy results of both drugs where a PValue < 0.05 was considered as significant value.Results: The mean age of group A participants were 48.4 + 11.1 years, whereas, in group B it was 48.2 + 11.5 years. There were 69.1% males and 30.9% females in group A compared to 80.4% males and 19.6% females ingroup B. After the 48 hour of end treatment, efficacy was 79.3% and 50.5%, in groups A and B respectively (p-value = 0.000).Conclusion: As compared to Cotrimoxazole, Ciprofloxacin is more effective in treating E. coli-caused urinary tract infections. How to cite this: Ayaz M, Kausar SAZ, Alamgir M, Muhammad S, Khan FM, Ullah S. Comparison of Efficacy of Ciprofloxacin and CoTrimoxazole in Escherichia Coli Urinary Tract Infection. Life and Science. 2024; 5(2): 151-159. doi: http://doi.org/10.37185/LnS.1.1.595
研究目的比较环丙沙星和联合曲唑对大肠杆菌引起的尿路感染的疗效：横断面研究。研究地点和时间：本研究于 2022 年 7 月 1 日至 2022 年 12 月 31 日在巴基斯坦白沙瓦穆罕默德教学医院（MTH）医学部进行：采用抽签法（双盲）将患者随机连续分配到任一组。共将 194 名确诊为大肠杆菌引起的尿路感染患者随机分为两组，每组 97 人，使用世界卫生组织的软件，环丙沙星的疗效为 54%，联合三唑的疗效为 74%，置信水平为 95%，检验功率为 90%。A组 "使用环丙沙星 500 毫克片剂，"B组 "使用联合曲唑 960 毫克片剂。在治疗 48 小时后，对所有招募的患者进行了随访，并记录了结果。采用卡方检验比较两种药物的疗效，PV 值小于 0.05 为显著值：A 组参与者的平均年龄为 48.4 + 11.1 岁，B 组参与者的平均年龄为 48.2 + 11.5 岁。治疗结束 48 小时后，A 组和 B 组的有效率分别为 79.3%和 50.5%（P 值 = 0.000）：结论：与复方新诺明相比，环丙沙星治疗由大肠杆菌引起的尿路感染更有效。引用方式Ayaz M, Kausar SAZ, Alamgir M, Muhammad S, Khan FM, Ullah S. Comparison of Efficacy of Ciprofloxacin and CoTrimoxazole in Escherichia Coli Urinary Tract Infection.生命与科学》。2024; 5(2):151-159. doi: http://doi.org/10.37185/LnS.1.1.595
{"title":"Comparison of Efficacy of Ciprofloxacin and Co-Trimoxazole in Escherichia Coli Urinary Tract Infection","authors":"Muhammad Ayaz, Sayed Ali Zeeshan Kausar, Muhammad Alamgir, Shafiq Muhammad, Fayaz Muhammad Khan, Sami Ullah","doi":"10.37185/lns.1.1.595","DOIUrl":"https://doi.org/10.37185/lns.1.1.595","url":null,"abstract":"Objective: To compare the efficacy of ciprofloxacin and co-trimoxazole in urinary tract infection due to Escherichia Coli.Study Design: A cross- sectional study. Place and Duration of Study: This study was conducted at the Department of Medicine, Muhammad TeachingHospital (MTH), Peshawar, Pakistan from 1 July 2022 to 31 December 2022.Methods: Patients were randomly and consecutively assigned to either group by using lottery method (double blind). A total of 194 patients diagnosed with urinary tract infection due to E coli were randomly divided into two groups, 97 patients in each group, using 54% efficacy of ciprofloxacin, 74% efficacy of Co-Trimoxazole, 95% confidence level, and 90% power of test, using WHO software. “Group-A' for Ciprofloxacin 500mg BD and th 'Group-B' for Co-Trimoxazole 960mg BD. All the recruited patients were followed up after the 48 hour of their treatment and results were recorded. The chi-Square test was applied to compare the efficacy results of both drugs where a PValue < 0.05 was considered as significant value.Results: The mean age of group A participants were 48.4 + 11.1 years, whereas, in group B it was 48.2 + 11.5 years. There were 69.1% males and 30.9% females in group A compared to 80.4% males and 19.6% females ingroup B. After the 48 hour of end treatment, efficacy was 79.3% and 50.5%, in groups A and B respectively (p-value = 0.000).Conclusion: As compared to Cotrimoxazole, Ciprofloxacin is more effective in treating E. coli-caused urinary tract infections. \u0000How to cite this: Ayaz M, Kausar SAZ, Alamgir M, Muhammad S, Khan FM, Ullah S. Comparison of Efficacy of Ciprofloxacin and CoTrimoxazole in Escherichia Coli Urinary Tract Infection. Life and Science. 2024; 5(2): 151-159. doi: http://doi.org/10.37185/LnS.1.1.595 \u0000 ","PeriodicalId":516717,"journal":{"name":"Life and Science","volume":" 7","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141129836","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Muhammad Aneel Razzaq, Muhammad Atif, Ubaid Ullah, Mohsin Mehmood, Muhammad Irfan, Kashif Sardar
Objective: To evaluate the role of acute exacerbation of COPD in the risk of atrial fibrillation. Study Design: Cross sectional study design.Place and Duration of Study: The study was conducted at Bakhtawar Amin Hospital Multan and Recep Tayyip Erdogan Hospital Muzaffargarh, Pakistan from March 2022 to March 2023.Methods: The patients with acute, hypercapnic chronic obstructive pulmonary disease(COPD) exacerbation were included in the study. A total of 200 patients were analyzed. Baseline data including demographic and clinical details, blood tests, ABG, systolic and diastolic blood pressure, ECG, pulmonary function test, and transthoracic echocardiography were recorded.Results: Of 200 patients, 40(20%) had an episode of paroxysmal atrial fibrillation (AF). Atrial fibrillation was more prevalent in cases with lower FEV1 (P<.05). In addition, it was also more common in cases with higher PaCO2 (P<.05). Atrial Fibrillation was significantly higher in cases with larger LA diameters (34.1 ± 2.3 mm vs 46.1 ± 2.3 mm, P<.05), area (22.8 ± 4.1 cm2 vs 34.1 ± 5.1 cm2, P<.05) and higher PASP (36.1 mmHg ± 2.2 vs 46.4 mmHg ± 3.7, P<.05). RA area was larger in patients with AF and COPD compared to those without AF (25.6 ± 5.1cm2 vs 30.2 ± 6.4 cm2, P<0.05). These findings suggest COPD patients are at increased risk of AF and require measures to reduce the risk. These data will be helpful for further investigation and development of strategies to prevent AF morbidities in COPD patients.Conclusion: In patients with acute exacerbations of chronic obstructive pulmonary disease, blood gas fluctuations, hemodynamic alterations, and abnormal pulmonary functions can lead to an increased risk of atrial fibrillation. How to cite this: Razzaq MA, Atif M, Ullah U, Mehmood M, Irfan M, Sardar K. The Risk of Atrial Fibrillation in Patients with Acute Exacerbation of Chronic Obstructive Pulmonary Disease. Life and Science. 2024; 5(2): 132-137. doi: http://doi.org/10.37185/LnS.1.1.487
目的：评估慢性阻塞性肺病急性加重对心房颤动风险的影响：评估慢性阻塞性肺病急性加重对心房颤动风险的影响。研究设计横断面研究设计：研究地点和时间：2022 年 3 月至 2023 年 3 月，在巴基斯坦木尔坦市巴赫塔瓦尔-阿明医院和穆扎法格尔市雷杰普-塔伊普-埃尔多安医院进行：研究对象包括急性、高碳酸血症慢性阻塞性肺疾病（COPD）加重的患者。共对 200 名患者进行了分析。记录的基线数据包括人口统计学和临床详情、血液化验、ABG、收缩压和舒张压、心电图、肺功能测试和经胸超声心动图：在 200 名患者中，有 40 人（20%）发作过阵发性心房颤动（房颤）。心房颤动在 FEV1 较低的病例中更为常见（P<.05）。此外，PaCO2 较高的病例也更容易发生心房颤动（P<.05）。在 LA 直径（34.1 ± 2.3 mm vs 46.1 ± 2.3 mm，P<.05）、面积（22.8 ± 4.1 cm2 vs 34.1 ± 5.1 cm2，P<.05）和 PASP（36.1 mmHg ± 2.2 vs 46.4 mmHg ± 3.7，P<.05）较大的病例中，心房颤动的发生率明显较高。与无房颤患者相比，房颤合并慢性阻塞性肺病患者的 RA 面积更大（25.6 ± 5.1 cm2 vs 30.2 ± 6.4 cm2，P<0.05）。这些研究结果表明，慢性阻塞性肺病患者罹患房颤的风险增加，需要采取措施降低风险。这些数据将有助于进一步调查和制定预防慢性阻塞性肺病患者房颤发病的策略：慢性阻塞性肺疾病急性加重期患者的血气波动、血流动力学改变和肺功能异常可导致房颤风险增加。 引用方式Razzaq MA, Atif M, Ullah U, Mehmood M, Irfan M, Sardar K. The Risk of Atrial Fibrillation in Patients with Acute Exacerbation of Chronic Obstructive Pulmonary Disease.生命与科学2024; 5(2):132-137. doi: http://doi.org/10.37185/LnS.1.1.487
{"title":"The Risk of Atrial Fibrillation in Patients with Acute Exacerbation of Chronic Obstructive Pulmonary Disease","authors":"Muhammad Aneel Razzaq, Muhammad Atif, Ubaid Ullah, Mohsin Mehmood, Muhammad Irfan, Kashif Sardar","doi":"10.37185/lns.1.1.487","DOIUrl":"https://doi.org/10.37185/lns.1.1.487","url":null,"abstract":"Objective: To evaluate the role of acute exacerbation of COPD in the risk of atrial fibrillation. Study Design: Cross sectional study design.Place and Duration of Study: The study was conducted at Bakhtawar Amin Hospital Multan and Recep Tayyip Erdogan Hospital Muzaffargarh, Pakistan from March 2022 to March 2023.Methods: The patients with acute, hypercapnic chronic obstructive pulmonary disease(COPD) exacerbation were included in the study. A total of 200 patients were analyzed. Baseline data including demographic and clinical details, blood tests, ABG, systolic and diastolic blood pressure, ECG, pulmonary function test, and transthoracic echocardiography were recorded.Results: Of 200 patients, 40(20%) had an episode of paroxysmal atrial fibrillation (AF). Atrial fibrillation was more prevalent in cases with lower FEV1 (P<.05). In addition, it was also more common in cases with higher PaCO2 (P<.05). Atrial Fibrillation was significantly higher in cases with larger LA diameters (34.1 ± 2.3 mm vs 46.1 ± 2.3 mm, P<.05), area (22.8 ± 4.1 cm2 vs 34.1 ± 5.1 cm2, P<.05) and higher PASP (36.1 mmHg ± 2.2 vs 46.4 mmHg ± 3.7, P<.05). RA area was larger in patients with AF and COPD compared to those without AF (25.6 ± 5.1cm2 vs 30.2 ± 6.4 cm2, P<0.05). These findings suggest COPD patients are at increased risk of AF and require measures to reduce the risk. These data will be helpful for further investigation and development of strategies to prevent AF morbidities in COPD patients.Conclusion: In patients with acute exacerbations of chronic obstructive pulmonary disease, blood gas fluctuations, hemodynamic alterations, and abnormal pulmonary functions can lead to an increased risk of atrial fibrillation. \u0000How to cite this: Razzaq MA, Atif M, Ullah U, Mehmood M, Irfan M, Sardar K. The Risk of Atrial Fibrillation in Patients with Acute Exacerbation of Chronic Obstructive Pulmonary Disease. Life and Science. 2024; 5(2): 132-137. doi: http://doi.org/10.37185/LnS.1.1.487","PeriodicalId":516717,"journal":{"name":"Life and Science","volume":" 45","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141129790","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Riffat Saeed, Anam Mahboob, Syed Mahmood Ali, Amer Latif, Tooba Ammar, Irfan Ali Kakepotto
Objective: To determine the frequency of need for postoperative intravenous analgesia after rectal diclofenac suppository in patients undergoing lower abdominal gynecological or obstetrical surgery under general anesthesiaStudy Design: Cross-sectional study.Place and Duration of Study: The study was carried out at the Operation Theater and Postoperative Ward of Sheikh Zayed Hospital, Lahore, Pakistan from January 2021 to July 2021.Methods: A total of 245 women undergoing gynecological and obstetrical surgeries under general anesthesia were enrolled in the study using non-probability consecutive sampling. All the participants were recruited after obtaining informed consent and meeting the inclusion criteria. All subjects had a single 100mg diclofenac suppository inserted rectally after undergoing general anesthesia, and their Visual Analog Scale (VAS) scores for postoperative analgesia were recorded immediately after surgery and again at 1, 6, and 24 hours.Results: The mean age of the patients was 37 years, with a standard deviation of 6.2. The mean VAS (Visual Analog Scale) scores at 1, 6, 12, and 24 hours were 3 (±1.24), 5 (±1.46), 7 (±1.93), and 6 (±2.14), respectively. The need for rescue analgesia was reported in 15.9% of cases at 1 hour, 37.1% at 6 hours, 82% at 12 hours, and 68.2% at 24 hours.Conclusion: The administration of diclofenac via rectal placement led to a notable decrease in Visual Analog Scale scores and a lower incidence of needing additional pain relief within the first 6 hours after surgery. How to cite this: Saeed R, Mahboob A, Ali SM, Latif A, Ammar T, Kakepotto IA. Requirement of Postoperative Analgesia after Per Rectal Placement of Diclofenac Sodium in Patients Undergoing Gynecological and Obstetrical Surgeries under General Anesthesia. Life and Science. 2024; 5(1): 120-125. doi: http://doi.org/10.37185/LnS.1.1.515
{"title":"Effectiveness of Postoperative Analgesia with Rectal Placement of Diclofenac Sodium in Patients Undergoing Gynecological and Obstetrical Surgeries under General Anesthesia","authors":"Riffat Saeed, Anam Mahboob, Syed Mahmood Ali, Amer Latif, Tooba Ammar, Irfan Ali Kakepotto","doi":"10.37185/lns.1.1.515","DOIUrl":"https://doi.org/10.37185/lns.1.1.515","url":null,"abstract":"Objective: To determine the frequency of need for postoperative intravenous analgesia after rectal diclofenac suppository in patients undergoing lower abdominal gynecological or obstetrical surgery under general anesthesiaStudy Design: Cross-sectional study.Place and Duration of Study: The study was carried out at the Operation Theater and Postoperative Ward of Sheikh Zayed Hospital, Lahore, Pakistan from January 2021 to July 2021.Methods: A total of 245 women undergoing gynecological and obstetrical surgeries under general anesthesia were enrolled in the study using non-probability consecutive sampling. All the participants were recruited after obtaining informed consent and meeting the inclusion criteria. All subjects had a single 100mg diclofenac suppository inserted rectally after undergoing general anesthesia, and their Visual Analog Scale (VAS) scores for postoperative analgesia were recorded immediately after surgery and again at 1, 6, and 24 hours.Results: The mean age of the patients was 37 years, with a standard deviation of 6.2. The mean VAS (Visual Analog Scale) scores at 1, 6, 12, and 24 hours were 3 (±1.24), 5 (±1.46), 7 (±1.93), and 6 (±2.14), respectively. The need for rescue analgesia was reported in 15.9% of cases at 1 hour, 37.1% at 6 hours, 82% at 12 hours, and 68.2% at 24 hours.Conclusion: The administration of diclofenac via rectal placement led to a notable decrease in Visual Analog Scale scores and a lower incidence of needing additional pain relief within the first 6 hours after surgery. \u0000How to cite this: Saeed R, Mahboob A, Ali SM, Latif A, Ammar T, Kakepotto IA. Requirement of Postoperative Analgesia after Per Rectal Placement of Diclofenac Sodium in Patients Undergoing Gynecological and Obstetrical Surgeries under General Anesthesia. Life and Science. 2024; 5(1): 120-125. doi: http://doi.org/10.37185/LnS.1.1.515","PeriodicalId":516717,"journal":{"name":"Life and Science","volume":"46 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140505940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Salisa Hassan Khan, Manzoor Ahmad, Zainab Abbas Mirza, Atif Sheraz, Mahpara Tariq
Objective: To compare the effect of uterine artery embolization and medical management on heavy menstrual bleeding in patients managed for uterine fibroids. Study Design: Comparative Cross-sectional Study. Place and Duration of Study: The study was conducted at the Department of Gynecology and Obstetrics, Pak Emirates Military Hospital (PEMH) Rawalpindi, Pakistan fromAugust 2021 to March 2023.Methods: Women between the ages of 35 and 50 years who presented with heavy menstrual bleeding and were diagnosed with leiomyomata were included in this study. They were divided into two groups via block randomization. Group-I underwent uterine artery embolization while group-II received medical treatment (gonadotropin-releasing hormone (GnRH) antagonist). Clinical factors like shrinkage in the size of fibroids, rise in hemoglobin levels, and pelvic pain scores were compared in both groups at the end of three months. Results: Out of 160 women recruited in the study, 52 (32.5%) were pre-menopausal, while 108 (67.5%) were peri menopausal. The mean age of patients who presented with heavy menstrual bleeding due to leiomyomata was 45.23 ±12.70 years. The mean rise in hemoglobin (p-value-0.007) and mean shrinkage size (p-value<0.001) were statistically significantly found more in patients who underwent uterine artery embolization as compared to those who took medical treatment. The mean pain score (p-value-0.01) was also found to be more in a group of patients who underwent uterine artery embolization.Conclusion: Uterine artery embolization emerged as an effective procedure for women managed for heavy menstrual bleeding due to uterine fibroids. Medical management via gonadotropin-releasing hormone (GnRH) antagonist was inferior in efficacy in terms of mean rise in hemoglobin and fibroid shrinkage.How to cite this: Khan S, Ahmad M, Mirza ZA, Sheraz A, Tariq M. The Effect of Uterine Artery Embolization on Heavy Menstrual Bleeding in Patients with Leiomyomata. Life and Science. 2024; 5(1): 27-32. doi: http://doi.org/10.37185/LnS.1.1.475
目的：比较子宫动脉栓塞术和药物治疗对子宫肌瘤患者月经大量出血的影响：比较子宫动脉栓塞术和药物治疗对子宫肌瘤患者月经大量出血的影响。研究设计：横断面比较研究。研究地点和时间：研究于 2021 年 8 月至 2023 年 3 月在巴基斯坦拉瓦尔品第 Pak Emirates 军事医院（PEMH）妇产科进行：研究对象： 年龄在 35 岁至 50 岁之间、月经大量出血并被确诊为子宫肌瘤的女性。她们被随机分为两组。第一组接受子宫动脉栓塞术，第二组接受药物治疗（促性腺激素释放激素（GnRH）拮抗剂）。三个月后，比较两组的临床因素，如肌瘤缩小、血红蛋白水平上升和盆腔疼痛评分。结果在这项研究招募的 160 名妇女中，52 人（32.5%）为绝经前妇女，108 人（67.5%）为围绝经期妇女。因子宫肌瘤导致月经大量出血的患者平均年龄为（45.23 ± 12.70）岁。与接受药物治疗的患者相比，接受子宫动脉栓塞治疗的患者血红蛋白的平均升高（p-值-0.007）和平均缩小（p-值<0.001）有显著统计学意义。接受子宫动脉栓塞治疗的一组患者的平均疼痛评分（p-value-0.01）也更高：结论：子宫动脉栓塞术对因子宫肌瘤导致月经大量出血的妇女来说是一种有效的治疗方法。通过促性腺激素释放激素（GnRH）拮抗剂进行药物治疗，在血红蛋白平均升高和肌瘤缩小方面疗效较差：Khan S, Ahmad M, Mirza ZA, Sheraz A, Tariq M. The Effect of Uterine Artery Embolization on Heavy Menstrual Bleeding in Patients with Leiomyomata.生命与科学》。2024; 5(1):27-32. DOI: http://doi.org/10.37185/LnS.1.1.475
{"title":"The Effect of Uterine Artery Embolization on Heavy Menstrual Bleeding in Patients with Leiomyomata","authors":"Salisa Hassan Khan, Manzoor Ahmad, Zainab Abbas Mirza, Atif Sheraz, Mahpara Tariq","doi":"10.37185/lns.1.1.475","DOIUrl":"https://doi.org/10.37185/lns.1.1.475","url":null,"abstract":"Objective: To compare the effect of uterine artery embolization and medical management on heavy menstrual bleeding in patients managed for uterine fibroids. Study Design: Comparative Cross-sectional Study. Place and Duration of Study: The study was conducted at the Department of Gynecology and Obstetrics, Pak Emirates Military Hospital (PEMH) Rawalpindi, Pakistan fromAugust 2021 to March 2023.Methods: Women between the ages of 35 and 50 years who presented with heavy menstrual bleeding and were diagnosed with leiomyomata were included in this study. They were divided into two groups via block randomization. Group-I underwent uterine artery embolization while group-II received medical treatment (gonadotropin-releasing hormone (GnRH) antagonist). Clinical factors like shrinkage in the size of fibroids, rise in hemoglobin levels, and pelvic pain scores were compared in both groups at the end of three months. Results: Out of 160 women recruited in the study, 52 (32.5%) were pre-menopausal, while 108 (67.5%) were peri menopausal. The mean age of patients who presented with heavy menstrual bleeding due to leiomyomata was 45.23 ±12.70 years. The mean rise in hemoglobin (p-value-0.007) and mean shrinkage size (p-value<0.001) were statistically significantly found more in patients who underwent uterine artery embolization as compared to those who took medical treatment. The mean pain score (p-value-0.01) was also found to be more in a group of patients who underwent uterine artery embolization.Conclusion: Uterine artery embolization emerged as an effective procedure for women managed for heavy menstrual bleeding due to uterine fibroids. Medical management via gonadotropin-releasing hormone (GnRH) antagonist was inferior in efficacy in terms of mean rise in hemoglobin and fibroid shrinkage.How to cite this: Khan S, Ahmad M, Mirza ZA, Sheraz A, Tariq M. The Effect of Uterine Artery Embolization on Heavy Menstrual Bleeding in Patients with Leiomyomata. Life and Science. 2024; 5(1): 27-32. doi: http://doi.org/10.37185/LnS.1.1.475","PeriodicalId":516717,"journal":{"name":"Life and Science","volume":"35 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140507119","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Rabail Zehra Raza, Irfan Hussain, Fatima Akhtar, Sara Mumtaz
Objective: To check which of the eight pro-hypertrophic transcription factors bind in abundance to a set of 140 functionally confirmed cardiac enhancers aiming to identify potential therapeutic targets for delaying the onset of cardiac hypertrophy. Study Design: Bioinformatics, in-Silico Study.Place and Duration of Study: The study was conducted at the Department of Biological Sciences, National University of Medical Sciences (NUMS), Rawalpindi, Pakistan, from January 2022 to December 2022.Methods: For experimentally verified human and mouse noncoding regions with gene enhancer activity measured in transgenic mice, VISTA Enhancer Browser was used to obtain 140 cardiac-specific functionally confirmed enhancers. Among these enhancers, transcription factor binding sites were computationally mapped to assess transcription factor occupancy. The binding sites for all eight transcription factors were screened in the collective set of 140 cardiac enhancers via an in-house script. Results: In this study, among a small set of eight pro-hypertrophic transcription factors, occupancy of transcription factor HAND (Heart- And Neural Crest Derivatives-Expressed Protein) was found to be maximum in the collected pool of functionally confirmed cardiac enhancers. Conclusion: The transcription factor HAND was found to have maximum binding occupancy among a set of experimentally confirmed cardiac enhancers.How to cite this: Raza RZ, Hussain I, Akhtar F, Mumtaz S. The Binding Occupancy of Pro-Hypertrophic Transcription Factors among Cardiac Developmental Enhancers. Life and Science. 2024; 5(1): 22-26. doi: http://doi.org/10.37185/LnS.1.1.464
目的检查八种促肥大转录因子中哪些因子与一组 140 个功能确认的心脏增强子大量结合，从而确定延缓心脏肥大发生的潜在治疗靶点。研究设计：研究地点和时间：研究于 2022 年 1 月至 2022 年 12 月在巴基斯坦拉瓦尔品第国立医科大学（NUMS）生物科学系进行：对于在转基因小鼠中测量到的具有基因增强子活性的实验验证的人类和小鼠非编码区，使用 VISTA Enhancer Browser 获得了 140 个心脏特异性功能确认增强子。在这些增强子中，通过计算绘制了转录因子结合位点，以评估转录因子的占有率。通过内部脚本在 140 个心脏增强子的集合中筛选了所有 8 个转录因子的结合位点。结果在这项研究中，在一小组八个促肥大转录因子中，发现转录因子 HAND（Heart- And Neural Crest Derivatives-Expressed Protein，心脏和神经冠衍生表达蛋白）在收集到的功能确认的心脏增强子库中占有率最高。结论在一组实验证实的心脏增强子中，转录因子 HAND 的结合占据率最高：Raza RZ, Hussain I, Akhtar F, Mumtaz S. The Binding Occupancy of Pro-Hypertrophic Transcription Factors among Cardiac Developmental Enhancers.生命与科学》。2024; 5(1):22-26. DOI: http://doi.org/10.37185/LnS.1.1.464
{"title":"The Binding Occupancy of Pro-Hypertrophic Transcription Factors among Cardiac Developmental Enhancers","authors":"Rabail Zehra Raza, Irfan Hussain, Fatima Akhtar, Sara Mumtaz","doi":"10.37185/lns.1.1.464","DOIUrl":"https://doi.org/10.37185/lns.1.1.464","url":null,"abstract":"Objective: To check which of the eight pro-hypertrophic transcription factors bind in abundance to a set of 140 functionally confirmed cardiac enhancers aiming to identify potential therapeutic targets for delaying the onset of cardiac hypertrophy. Study Design: Bioinformatics, in-Silico Study.Place and Duration of Study: The study was conducted at the Department of Biological Sciences, National University of Medical Sciences (NUMS), Rawalpindi, Pakistan, from January 2022 to December 2022.Methods: For experimentally verified human and mouse noncoding regions with gene enhancer activity measured in transgenic mice, VISTA Enhancer Browser was used to obtain 140 cardiac-specific functionally confirmed enhancers. Among these enhancers, transcription factor binding sites were computationally mapped to assess transcription factor occupancy. The binding sites for all eight transcription factors were screened in the collective set of 140 cardiac enhancers via an in-house script. Results: In this study, among a small set of eight pro-hypertrophic transcription factors, occupancy of transcription factor HAND (Heart- And Neural Crest Derivatives-Expressed Protein) was found to be maximum in the collected pool of functionally confirmed cardiac enhancers. Conclusion: The transcription factor HAND was found to have maximum binding occupancy among a set of experimentally confirmed cardiac enhancers.How to cite this: Raza RZ, Hussain I, Akhtar F, Mumtaz S. The Binding Occupancy of Pro-Hypertrophic Transcription Factors among Cardiac Developmental Enhancers. Life and Science. 2024; 5(1): 22-26. doi: http://doi.org/10.37185/LnS.1.1.464","PeriodicalId":516717,"journal":{"name":"Life and Science","volume":"31 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140507205","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Tayyaba Fahad, Shabana Ali, Tayyaba Qureshi, Noor Fatima Khan
Objective: To determine the effect of maternal hypothyroidism on the development of neurons in the motor cortex of rat pups by using light microscopy. Study Design: Laboratory-based experimental study.Place and Duration of Study: The study was carried out in collaboration with the National Institute of Health (NIH) Islamabad and the Department of Anatomy, Islamic International Medical College, Riphah International University, Islamabad, Pakistan from March 2023 to May 2023.Methods: In this study, 24 females and 12 male Sprague dawley rats were sorted into control and hypothyroid groups. The control group received a standard diet and plain drinking water throughout the study. In contrast, the hypothyroid group had 4.5mg of propylthiouracil administered per rat per day, mixed into their drinking water. This treatment started a week before mating and continued until three weeks after delivery. Once successful mating was confirmed via vaginal plugs, gestation proceeded, and newborn pups were born after nd three weeks, having full access to maternal lactation for 21 days. On the 22 day after birth, dissection took place, and the brains of the pups were carefully removed. Coronal sections of the motor cortex were then obtained for subsequent examination.Results: The control group displayed a typical pattern of neurogenesis, characterized by the normal structure of cortical neurons. On the other hand, intracellular vacuolation, glial cell necrosis, and reduced Nissl rim thickness were statistically significant in hypothyroid group which collectively pointed to atypical neurogenesis. Conclusion: This study highlights the adverse effects of maternal hypothyroidism on the structural integrity of cortical neurons. It focuses on increasing awareness and implementing thorough prenatal healthcare strategies.How to cite this: Fahad T, Ali S, Qureshi T, Khan NF. Maternal Hypothyroidism-Induced Impaired Development of Neurons in Rat Offspring: Insights for Antenatal Care. Life and Science. 2024; 5(1): 68-74. doi: http://doi.org/10.37185/LnS.1.1.525
{"title":"Maternal Hypothyroidism-Induced Impaired Development of Neurons in Rat Offspring: Insights for Antenatal Care","authors":"Tayyaba Fahad, Shabana Ali, Tayyaba Qureshi, Noor Fatima Khan","doi":"10.37185/lns.1.1.525","DOIUrl":"https://doi.org/10.37185/lns.1.1.525","url":null,"abstract":"Objective: To determine the effect of maternal hypothyroidism on the development of neurons in the motor cortex of rat pups by using light microscopy. Study Design: Laboratory-based experimental study.Place and Duration of Study: The study was carried out in collaboration with the National Institute of Health (NIH) Islamabad and the Department of Anatomy, Islamic International Medical College, Riphah International University, Islamabad, Pakistan from March 2023 to May 2023.Methods: In this study, 24 females and 12 male Sprague dawley rats were sorted into control and hypothyroid groups. The control group received a standard diet and plain drinking water throughout the study. In contrast, the hypothyroid group had 4.5mg of propylthiouracil administered per rat per day, mixed into their drinking water. This treatment started a week before mating and continued until three weeks after delivery. Once successful mating was confirmed via vaginal plugs, gestation proceeded, and newborn pups were born after nd three weeks, having full access to maternal lactation for 21 days. On the 22 day after birth, dissection took place, and the brains of the pups were carefully removed. Coronal sections of the motor cortex were then obtained for subsequent examination.Results: The control group displayed a typical pattern of neurogenesis, characterized by the normal structure of cortical neurons. On the other hand, intracellular vacuolation, glial cell necrosis, and reduced Nissl rim thickness were statistically significant in hypothyroid group which collectively pointed to atypical neurogenesis. Conclusion: This study highlights the adverse effects of maternal hypothyroidism on the structural integrity of cortical neurons. It focuses on increasing awareness and implementing thorough prenatal healthcare strategies.How to cite this: Fahad T, Ali S, Qureshi T, Khan NF. Maternal Hypothyroidism-Induced Impaired Development of Neurons in Rat Offspring: Insights for Antenatal Care. Life and Science. 2024; 5(1): 68-74. doi: http://doi.org/10.37185/LnS.1.1.525","PeriodicalId":516717,"journal":{"name":"Life and Science","volume":"18 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140507450","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective: To compare the effectiveness of myo-inositol versus metformin in treating women with polycystic ovary syndrome.Study Design: Cross-sectional study.Place and Duration of Study: The study was carried out at the Department of Gynae Unit II, Dr. Ruth. K.M. Pfau th th Civil Hospital Karachi, Pakistan from 7 February 2019 to 6 August 2019.Methods: All eligible patients who visited the hospital were enrolled. The group-Aincluded females who received myo-inositol (n=35), whereas the group-B included females who received metformin (n=35). Females in the myo-inositol group were administered 1 gram of myo-inositol twice daily, while those in the metformin group were administered 500 mg of metformin twice daily. Regular follow-up visits were scheduled every two months, and the efficacy of the treatment was assessed after six months. Efficacy was evaluated in terms of the normalization of menstrual cycles and the achievement of ovulation.Results: The mean age in the myo-inositol and metformin groups was 23.92±3.70 and 23.68±4.23, respectively. The mean weight in the myoinositol and metformin groups was 59.23±2.07 and 61.79±5.92, respectively. Notably, the efficacy rates for the myo-inositol and metformin groups were 68.57% and 20%, respectively with p-value=0.001.Conclusion: Myo-inositol was found to demonstrate significant superiority over metformin in the treatment of polycystic ovary syndrome.How to cite this: Latif N, Rajar S, Yousuf M, Imtiaz S, Abbas S, Jamali Z. Comparison of Efficacy Between Myo-Inositol versus Metformin in Women with Polycystic Ovary Syndrome. Life and Science. 2024; 5(1): 48-53. doi: http://doi.org/10.37185/LnS.1.1.486
研究目的比较肌醇与二甲双胍治疗多囊卵巢综合征妇女的效果：横断面研究：研究地点和时间：研究在鲁思博士（Dr. Ruth. K.M. Pfau th.K.M. Pfau th th Civil Hospital Karachi, Pakistan from 7 February 2019 to 6 August 2019.Methods：所有到医院就诊的符合条件的患者均被纳入。A组包括接受肌醇治疗的女性（35人），B组包括接受二甲双胍治疗的女性（35人）。肌醇组女性每天服用两次肌醇，每次1克；二甲双胍组女性每天服用两次二甲双胍，每次500毫克。每两个月进行一次定期随访，六个月后对疗效进行评估。疗效根据月经周期是否正常和是否排卵进行评估：肌醇组和二甲双胍组的平均年龄分别为（23.92±3.70）岁和（23.68±4.23）岁。肌醇组和二甲双胍组的平均体重分别为（59.23±2.07）和（61.79±5.92）。值得注意的是，肌醇组和二甲双胍组的有效率分别为 68.57% 和 20%，P 值=0.001：在治疗多囊卵巢综合征方面，肌醇明显优于二甲双胍：Latif N, Rajar S, Yousuf M, Imtiaz S, Abbas S, Jamali Z.肌醇与二甲双胍对多囊卵巢综合征妇女的疗效比较》。生命与科学2024; 5(1):48-53. doi: http://doi.org/10.37185/LnS.1.1.486
{"title":"Comparison of Efficacy between Myo-Inositol versus Metformin in Women with Polycystic Ovary Syndrome","authors":"Nurmeen Latif, Seema Rajar, Mehreen Yousuf, Sadaf Imtiaz, Sidrah Abbas, Zara Jamali","doi":"10.37185/lns.1.1.486","DOIUrl":"https://doi.org/10.37185/lns.1.1.486","url":null,"abstract":"Objective: To compare the effectiveness of myo-inositol versus metformin in treating women with polycystic ovary syndrome.Study Design: Cross-sectional study.Place and Duration of Study: The study was carried out at the Department of Gynae Unit II, Dr. Ruth. K.M. Pfau th th Civil Hospital Karachi, Pakistan from 7 February 2019 to 6 August 2019.Methods: All eligible patients who visited the hospital were enrolled. The group-Aincluded females who received myo-inositol (n=35), whereas the group-B included females who received metformin (n=35). Females in the myo-inositol group were administered 1 gram of myo-inositol twice daily, while those in the metformin group were administered 500 mg of metformin twice daily. Regular follow-up visits were scheduled every two months, and the efficacy of the treatment was assessed after six months. Efficacy was evaluated in terms of the normalization of menstrual cycles and the achievement of ovulation.Results: The mean age in the myo-inositol and metformin groups was 23.92±3.70 and 23.68±4.23, respectively. The mean weight in the myoinositol and metformin groups was 59.23±2.07 and 61.79±5.92, respectively. Notably, the efficacy rates for the myo-inositol and metformin groups were 68.57% and 20%, respectively with p-value=0.001.Conclusion: Myo-inositol was found to demonstrate significant superiority over metformin in the treatment of polycystic ovary syndrome.How to cite this: Latif N, Rajar S, Yousuf M, Imtiaz S, Abbas S, Jamali Z. Comparison of Efficacy Between Myo-Inositol versus Metformin in Women with Polycystic Ovary Syndrome. Life and Science. 2024; 5(1): 48-53. doi: http://doi.org/10.37185/LnS.1.1.486","PeriodicalId":516717,"journal":{"name":"Life and Science","volume":"23 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140508018","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mehwish Mehmood, A. Aslam, Waqas Ahmed, Sameena Aman, Ahmed Ali, Hira Feroze, Nousheen Saleem
Objective: To determine the frequency of awareness and acceptability of breast reconstruction surgery among women in the twin cities of Islamabad and Rawalpindi.Study Design: Cross-sectional study.Place and Duration of Study: The study was carried out at the Department of Plastic Surgery, Fauji Foundation Hospital, Rawalpindi, Pakistan, from October 2022 to June 2023.Methods: A total of 271 patients between 20-70 years of age with a diagnosis of breast cancer were included. Demographic details, including marital status, education, residence, occupation, family history, awareness of breast reconstruction, and source of information about breast reconstruction, were documented on a proforma. All patients received information regarding breast reconstruction, and records of the frequency of acceptability and contributing factors were made. Data analysis was carried out by using SPSS 25.0.Results: The mean age of patients was 43.41 ± 8.98 years. Out of 271 patients, 114 patients (42.1%) had an awareness of breast reconstruction. The primary source of information was the treating physician in 60 out of 114 patients (52.6%). Breast reconstruction acceptability was reported in 110 out of 271 patients (40.6%). Family support was the most common reason for acceptance in 43 out of 110 patients (39.1%).Conclusion: Efforts need to be made at the community level to educate the general population about breast cancer treatment options, including breast reconstruction. Education was significantly associated with increased awareness and acceptability for breast reconstruction. Better cosmetic outcomes and family support were the factors for increased acceptability, while financial constraints and family pressures were reasons for the vice versa.How to cite this: Mehmood M, Aslam A, Ahmed W, Aman S, Ali A, Feroze H, Saleem N. Awareness and Acceptability of Breast Reconstruction Among Women with Breast Cancer in Twin Cities of Islamabad and Rawalpindi. Life and Science. 2024; 5(1): 9-15. doi: http://doi.org/10.37185/LnS.1.1.509
研究目的研究设计：横断面研究：横断面研究：研究地点和时间：2022年10月至2023年6月，在巴基斯坦拉瓦尔品第市福吉基金会医院整形外科进行：方法：共纳入 271 名年龄在 20-70 岁之间、确诊为乳腺癌的患者。在一份表格上记录了详细的人口统计学信息，包括婚姻状况、教育程度、居住地、职业、家族史、对乳房再造的认识以及乳房再造信息的来源。所有患者都收到了有关乳房再造的信息，并记录了接受乳房再造的频率和诱因。数据分析采用 SPSS 25.0 进行：患者的平均年龄为（43.41 ± 8.98）岁。在 271 名患者中，114 名患者（42.1%）对乳房再造有所了解。114 名患者中有 60 名（52.6%）的主要信息来源是主治医生。271 名患者中有 110 名（40.6%）表示可以接受乳房再造。110名患者中有43名（39.1%）接受乳房再造，家庭支持是最常见的原因：结论：需要在社区层面努力向大众宣传乳腺癌治疗方案，包括乳房再造。教育与乳房再造认知度和接受度的提高有很大关系。更好的美容效果和家庭支持是提高接受度的因素，而经济拮据和家庭压力则是反之的原因：Mehmood M, Aslam A, Ahmed W, Aman S, Ali A, Feroze H, Saleem N. 《伊斯兰堡和拉瓦尔品第双城乳腺癌妇女对乳房再造的认识和接受度》。生命与科学》。2024; 5(1):9-15. doi: http://doi.org/10.37185/LnS.1.1.509
{"title":"Awareness and Acceptability of Breast Reconstruction Among Women with Breast Cancer in Twin Cities of Islamabad and Rawalpindi","authors":"Mehwish Mehmood, A. Aslam, Waqas Ahmed, Sameena Aman, Ahmed Ali, Hira Feroze, Nousheen Saleem","doi":"10.37185/lns.1.1.509","DOIUrl":"https://doi.org/10.37185/lns.1.1.509","url":null,"abstract":"Objective: To determine the frequency of awareness and acceptability of breast reconstruction surgery among women in the twin cities of Islamabad and Rawalpindi.Study Design: Cross-sectional study.Place and Duration of Study: The study was carried out at the Department of Plastic Surgery, Fauji Foundation Hospital, Rawalpindi, Pakistan, from October 2022 to June 2023.Methods: A total of 271 patients between 20-70 years of age with a diagnosis of breast cancer were included. Demographic details, including marital status, education, residence, occupation, family history, awareness of breast reconstruction, and source of information about breast reconstruction, were documented on a proforma. All patients received information regarding breast reconstruction, and records of the frequency of acceptability and contributing factors were made. Data analysis was carried out by using SPSS 25.0.Results: The mean age of patients was 43.41 ± 8.98 years. Out of 271 patients, 114 patients (42.1%) had an awareness of breast reconstruction. The primary source of information was the treating physician in 60 out of 114 patients (52.6%). Breast reconstruction acceptability was reported in 110 out of 271 patients (40.6%). Family support was the most common reason for acceptance in 43 out of 110 patients (39.1%).Conclusion: Efforts need to be made at the community level to educate the general population about breast cancer treatment options, including breast reconstruction. Education was significantly associated with increased awareness and acceptability for breast reconstruction. Better cosmetic outcomes and family support were the factors for increased acceptability, while financial constraints and family pressures were reasons for the vice versa.How to cite this: Mehmood M, Aslam A, Ahmed W, Aman S, Ali A, Feroze H, Saleem N. Awareness and Acceptability of Breast Reconstruction Among Women with Breast Cancer in Twin Cities of Islamabad and Rawalpindi. Life and Science. 2024; 5(1): 9-15. doi: http://doi.org/10.37185/LnS.1.1.509","PeriodicalId":516717,"journal":{"name":"Life and Science","volume":"55 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140508044","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective: The study aims to determine the diagnostic accuracy of digital breast tomosynthesis in diagnosing malignant and benign lesions, keeping histopathology as the gold standard.Study Design: Cross-sectional study.Place and Duration of Study: The study was carried out at the Department of Diagnostic Radiology, POF th th Hospital, Wah Cantt, Pakistan over a period of six months from 11th July 2021 to 11th January 2022.Methods: A total of 200 women presenting with suspicion of breast malignancy were selected consecutively from the outpatient department, and Digital Breast Tomosynthesis(DBT) was performed, followed by a biopsy of the specimen to confirm the findings on histopathology. Results: The average age of the sample was 48.3 + 7.1 years, ranging between 35 and 60 years. Palpable breast lump was recorded in 44.5%, pain in 33%, and nipple discharge in 35.5%. Family history of breast Ca was present in 25.5. On Digital Breast Tomosynthesis (DBT), 58.5% of lesions were labeled as malignant, while 53.5% were labeled as malignant on follow-up histopathology. On applying the formulae for calculation, the sensitivity of DBT was found to be 86% and specificity 73.1%. The positive predictive value of the DBT is 78.6%, and the negative predictive value is 81.9%.Conclusion: In conclusion, Digital Breast Tomosynthesisis a significantly sensitive and specific tool for detecting malignant breast lesions in women suspected of breast carcinoma.How to cite this: Afzal K, Gul N, Mehmood K, Jawwad S, Iqbal B. Assessment of Diagnostic Accuracy of Digital Breast Tomosynthesis in Distinguishing Malignant and Benign Breast Lesions. Life and Science. 2024; 5(1): 3-8. doi: http://doi.org/10.37185/LnS.1.1.416
研究目的研究旨在确定数字乳腺断层扫描在诊断恶性和良性病变方面的诊断准确性，并将组织病理学作为金标准：横断面研究：研究地点和时间：2021 年 7 月 11 日至 2022 年 1 月 11 日，为期 6 个月，在巴基斯坦 Wah Cantt 市 POF th th 医院放射诊断部进行：方法：从门诊部连续选取 200 名怀疑患有乳腺恶性肿瘤的妇女，进行数字乳腺断层扫描（DBT），然后对标本进行活检，以确认组织病理学检查结果。结果样本的平均年龄为 48.3 + 7.1 岁，介于 35 岁和 60 岁之间。可触及乳房肿块的占 44.5%，疼痛的占 33%，乳头溢液的占 35.5%。25.5%的患者有乳腺癌家族史。在数字乳腺断层扫描（DBT）中，58.5%的病变被标记为恶性，而在后续组织病理学检查中，53.5%的病变被标记为恶性。根据计算公式，DBT 的灵敏度为 86%，特异度为 73.1%。DBT的阳性预测值为78.6%，阴性预测值为81.9%：总之，数字乳腺断层扫描是检测疑似乳腺癌妇女乳腺恶性病变的敏感性和特异性都很高的工具：Afzal K, Gul N, Mehmood K, Jawwad S, Iqbal B. Assessment of Diagnostic Accuracy of Digital Breast Tomosynthesis in Distinguishing Malignant and Benign Breast Lesions.生命与科学》。2024; 5(1):3-8. doi: http://doi.org/10.37185/LnS.1.1.416
{"title":"Assessment of Diagnostic Accuracy of Digital Breast Tomosynthesis in Distinguishing Malignant and Benign Breast Lesions","authors":"Kanza Afzal, Nadia Gul, Khalid Mehmood, Sobia Jawwad, Bushra Iqbal","doi":"10.37185/lns.1.1.416","DOIUrl":"https://doi.org/10.37185/lns.1.1.416","url":null,"abstract":"Objective: The study aims to determine the diagnostic accuracy of digital breast tomosynthesis in diagnosing malignant and benign lesions, keeping histopathology as the gold standard.Study Design: Cross-sectional study.Place and Duration of Study: The study was carried out at the Department of Diagnostic Radiology, POF th th Hospital, Wah Cantt, Pakistan over a period of six months from 11th July 2021 to 11th January 2022.Methods: A total of 200 women presenting with suspicion of breast malignancy were selected consecutively from the outpatient department, and Digital Breast Tomosynthesis(DBT) was performed, followed by a biopsy of the specimen to confirm the findings on histopathology. Results: The average age of the sample was 48.3 + 7.1 years, ranging between 35 and 60 years. Palpable breast lump was recorded in 44.5%, pain in 33%, and nipple discharge in 35.5%. Family history of breast Ca was present in 25.5. On Digital Breast Tomosynthesis (DBT), 58.5% of lesions were labeled as malignant, while 53.5% were labeled as malignant on follow-up histopathology. On applying the formulae for calculation, the sensitivity of DBT was found to be 86% and specificity 73.1%. The positive predictive value of the DBT is 78.6%, and the negative predictive value is 81.9%.Conclusion: In conclusion, Digital Breast Tomosynthesisis a significantly sensitive and specific tool for detecting malignant breast lesions in women suspected of breast carcinoma.How to cite this: Afzal K, Gul N, Mehmood K, Jawwad S, Iqbal B. Assessment of Diagnostic Accuracy of Digital Breast Tomosynthesis in Distinguishing Malignant and Benign Breast Lesions. Life and Science. 2024; 5(1): 3-8. doi: http://doi.org/10.37185/LnS.1.1.416 \u0000 ","PeriodicalId":516717,"journal":{"name":"Life and Science","volume":"13 9","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140508354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Prem Lata, Shaista Hayat, Vinesh Kumar, Muhammad Faizan Hassan, Sana Batool, Khadijatul Ain Sandeela, Komal Jamil
Objective: To determine the effects of body mass index and ankle dorsiflexion in patients with plantar fasciitis.Study Design: A cross-sectional.Place and Duration of Study: The study was carried out at the Department of Physical Therapy of the two leading tertiary care centers, Advance Orthopedic & Reconstructive Institute & Dr. Ziauddin Hospital Karachi, Pakistan from August 2022 to June 2023.Methods: Sixty-Four participants were recruited from the physical therapy departments of two tertiary care centers in Karachi by convenience sampling. The study focuses on the impact of demographics on the performance of plantar fasciitis patients. The measurement tools used in this are BMI (Body mass index), NRS (Numeric rating scale), LEFS (Lower extremity functional scale), and Goniometer. The data were analyzed by SPSS version 23.0. Results: Our findings show that plantar fasciitis is more common in the obese-II category with reference to BMI, females are more affected than males with reference to gender, the middle age group is more affected with reference to age and dorsiflexion angle of patients is less than normal range shows the directly proportional of demographics with the performance of patients with plantar fasciitis.Conclusion: Our study showed the positive effect of ankle dorsiflexion angle and BMI, gender, pain, and age on the physical performance of plantar fasciitis patients. How to cite this: Lata P, Hayat S, Kumar V, Hassan MF, Batool S, Sandeela KA, Jamil K. Effect of Body Mass Index and Ankle Dorsiflexion in Planter Fascitis Patients; Performance Perspective. Life and Science. 2024; 5(1): 113-119. doi: http://doi.org/10.37185/LnS.1.1.461
研究目的确定体重指数和踝关节外翻对足底筋膜炎患者的影响：研究地点和时间：研究地点和时间：研究于 2022 年 8 月至 2023 年 6 月在巴基斯坦卡拉奇的两家领先的三级医疗中心：Advance Orthopedic & Reconstructive Institute 和 Dr. Ziauddin Hospital 的物理治疗部进行：通过方便抽样，从卡拉奇两家三级医疗中心的理疗科招募了 64 名参与者。研究重点是人口统计学对足底筋膜炎患者表现的影响。研究中使用的测量工具包括 BMI（体重指数）、NRS（数字评分量表）、LEFS（下肢功能量表）和动态关节角度计。数据采用 SPSS 23.0 版进行分析。结果我们的研究结果表明，根据体重指数（BMI），足底筋膜炎在肥胖-II 类人群中更为常见；根据性别，女性比男性更易患病；根据年龄，中年群体更易患病；患者的背屈角度小于正常范围，这表明人口统计学与足底筋膜炎患者的表现成正比：我们的研究表明，踝关节背屈角度、体重指数、性别、疼痛和年龄对足底筋膜炎患者的体能表现有积极影响。引用方式Lata P, Hayat S, Kumar V, Hassan MF, Batool S, Sandeela KA, Jamil K. 《足底筋膜炎患者体重指数和踝关节背屈的影响；表现视角》。生命与科学》。2024; 5(1):113-119. DOI: http://doi.org/10.37185/LnS.1.1.461
{"title":"Effect of Body Mass Index and Ankle Dorsiflexion in Planter Fasciitis Patients; Performance Perspective","authors":"Prem Lata, Shaista Hayat, Vinesh Kumar, Muhammad Faizan Hassan, Sana Batool, Khadijatul Ain Sandeela, Komal Jamil","doi":"10.37185/lns.1.1.461","DOIUrl":"https://doi.org/10.37185/lns.1.1.461","url":null,"abstract":"Objective: To determine the effects of body mass index and ankle dorsiflexion in patients with plantar fasciitis.Study Design: A cross-sectional.Place and Duration of Study: The study was carried out at the Department of Physical Therapy of the two leading tertiary care centers, Advance Orthopedic & Reconstructive Institute & Dr. Ziauddin Hospital Karachi, Pakistan from August 2022 to June 2023.Methods: Sixty-Four participants were recruited from the physical therapy departments of two tertiary care centers in Karachi by convenience sampling. The study focuses on the impact of demographics on the performance of plantar fasciitis patients. The measurement tools used in this are BMI (Body mass index), NRS (Numeric rating scale), LEFS (Lower extremity functional scale), and Goniometer. The data were analyzed by SPSS version 23.0. Results: Our findings show that plantar fasciitis is more common in the obese-II category with reference to BMI, females are more affected than males with reference to gender, the middle age group is more affected with reference to age and dorsiflexion angle of patients is less than normal range shows the directly proportional of demographics with the performance of patients with plantar fasciitis.Conclusion: Our study showed the positive effect of ankle dorsiflexion angle and BMI, gender, pain, and age on the physical performance of plantar fasciitis patients. \u0000How to cite this: Lata P, Hayat S, Kumar V, Hassan MF, Batool S, Sandeela KA, Jamil K. Effect of Body Mass Index and Ankle Dorsiflexion in Planter Fascitis Patients; Performance Perspective. Life and Science. 2024; 5(1): 113-119. doi: http://doi.org/10.37185/LnS.1.1.461","PeriodicalId":516717,"journal":{"name":"Life and Science","volume":"3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140508534","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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