Septic arthritis is a serious medical emergency associated with high morbidity and mortality. A 49-year-old man with diabetes undergoing hemodialysis developed right shoulder pain and fever following his sixth dose of the COVID-19 vaccine. Twelve days after vaccination, his fever persisted, and computed tomography imaging revealed a fluid collection around the right shoulder joint. Culture of the synovial fluid detected methicillin-susceptible Staphylococcus aureus