<p>A 77-year-old man began receiving home care services at the request of his wife, reporting that the patient had been experiencing a persistent cough and wheezing for 2 weeks yet resolutely refused to seek medical care outside the home. The patient had retired prematurely from his office career at the age of 56 and thereafter engaged primarily in recreational sports and home carpentry. Two months before, he experienced a noticeable decline in appetite. One month before, he began spending most of his days bedridden due to pronounced fatigue, giving up his usual activities such as exercise and household chores. Two weeks prior, he developed a productive cough, which progressively worsened. Three days before, he had a severe episode of coughing, wheezing, and rapid breathing in the early morning. His wife recorded a body temperature of 36.5°C and an oxygen saturation level of 90% on ambient air. His wife eventually asked for home care, and the medical team conducted a home visit to assess his condition. The patient reported experiencing mild, dull pain in the right side of the chest and upper arm, though he was uncertain when it had begun. He also noted a weight loss of three kilograms over 3 months.</p><p>For many years, the patient had steadfastly avoided seeking medical attention at a hospital for unknown reasons and had no history of regular medication use. Routine medical examinations during his working years had not revealed any abnormalities. He had a history of heavy smoking, consuming 20–30 cigarettes daily since the age of 14, though he ceased smoking upon the recent onset of his cough. He consumed alcohol infrequently. Per his wife and daughter, he suffered from visual impairment, and his refusal to seek medical care was driven by a desire to conceal this condition from others.</p><p>The patient was reclined on the bed, fully conscious and articulate, with no observable signs of respiratory distress during conversation. Vital signs were recorded as follows: body temperature, 36.9°C; blood pressure, 144/60 mmHg; heart rate, 90 bpm; respiratory rate, 24 per minute; and oxygen saturation, 97% on ambient air. The mildly prolonged expiratory phase was noted.</p><p>Physical examination revealed a point of maximal impulse along the left midclavicular line, without any palpable thrill. The sternocleidomastoid muscle was hypertrophied, and the laryngeal height (distance from the thyroid cartilage to the suprasternal notch) was reduced. Cardiac auscultation detected a Levine grade II/VI holosystolic murmur, most prominent at the fourth left sternal border and radiating toward the left axilla. Mild holo-expiratory wheezes were present throughout the chest, and egophony was localized to the right anterior chest area. There was no tenderness or tactile fremitus, and percussion revealed resonant tones across all lung fields.</p><p>There were non-pale conjunctivae, and the jugular veins were not distended. No tenderness was noted over the extremities
{"title":"Homemade and Handmade","authors":"Junki Mizumoto, Taro Shimizu","doi":"10.1002/jgf2.70077","DOIUrl":"https://doi.org/10.1002/jgf2.70077","url":null,"abstract":"<p>A 77-year-old man began receiving home care services at the request of his wife, reporting that the patient had been experiencing a persistent cough and wheezing for 2 weeks yet resolutely refused to seek medical care outside the home. The patient had retired prematurely from his office career at the age of 56 and thereafter engaged primarily in recreational sports and home carpentry. Two months before, he experienced a noticeable decline in appetite. One month before, he began spending most of his days bedridden due to pronounced fatigue, giving up his usual activities such as exercise and household chores. Two weeks prior, he developed a productive cough, which progressively worsened. Three days before, he had a severe episode of coughing, wheezing, and rapid breathing in the early morning. His wife recorded a body temperature of 36.5°C and an oxygen saturation level of 90% on ambient air. His wife eventually asked for home care, and the medical team conducted a home visit to assess his condition. The patient reported experiencing mild, dull pain in the right side of the chest and upper arm, though he was uncertain when it had begun. He also noted a weight loss of three kilograms over 3 months.</p><p>For many years, the patient had steadfastly avoided seeking medical attention at a hospital for unknown reasons and had no history of regular medication use. Routine medical examinations during his working years had not revealed any abnormalities. He had a history of heavy smoking, consuming 20–30 cigarettes daily since the age of 14, though he ceased smoking upon the recent onset of his cough. He consumed alcohol infrequently. Per his wife and daughter, he suffered from visual impairment, and his refusal to seek medical care was driven by a desire to conceal this condition from others.</p><p>The patient was reclined on the bed, fully conscious and articulate, with no observable signs of respiratory distress during conversation. Vital signs were recorded as follows: body temperature, 36.9°C; blood pressure, 144/60 mmHg; heart rate, 90 bpm; respiratory rate, 24 per minute; and oxygen saturation, 97% on ambient air. The mildly prolonged expiratory phase was noted.</p><p>Physical examination revealed a point of maximal impulse along the left midclavicular line, without any palpable thrill. The sternocleidomastoid muscle was hypertrophied, and the laryngeal height (distance from the thyroid cartilage to the suprasternal notch) was reduced. Cardiac auscultation detected a Levine grade II/VI holosystolic murmur, most prominent at the fourth left sternal border and radiating toward the left axilla. Mild holo-expiratory wheezes were present throughout the chest, and egophony was localized to the right anterior chest area. There was no tenderness or tactile fremitus, and percussion revealed resonant tones across all lung fields.</p><p>There were non-pale conjunctivae, and the jugular veins were not distended. No tenderness was noted over the extremities ","PeriodicalId":51861,"journal":{"name":"Journal of General and Family Medicine","volume":"26 6","pages":"534-538"},"PeriodicalIF":2.3,"publicationDate":"2025-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jgf2.70077","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145436324","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
<p>The patient is a 19-year-old female with a history of tonic–clonic seizures. Treatment with valproic acid (VPA) began at age 3 and was discontinued upon achieving seizure freedom at age 10. At age 14, she experienced maternal abuse and school difficulties, followed by episodes of collapse and unresponsiveness, sometimes with foaming at the mouth and small shaking, lasting up to an hour. She was diagnosed with a dissociative disorder at a psychiatric clinic. At age 17, she was admitted to the emergency room for a similar seizure and began treatment for epilepsy with levetiracetam and VPA. At age 19, she underwent video electroencephalography (VEEG) to address persistent intractable seizures.</p><p>After discontinuation of antiepileptic medications, VEEG was performed over 4 days. On day 2, a psychogenic nonepileptic seizure (PNES) was recorded. Although lying in bed and stating she felt “sick,” she abruptly exhibited bilateral shoulder twitching, unresponsiveness, and foaming at the mouth, but lacked tonic posturing, cyanosis, or oxygen desaturation, with her eyes remaining closed (Figure 1A). The EEG showed a normal posterior-dominant rhythm (9–10 Hz) without epileptiform activity (Figure 1B). The physician examined her 5 min after seizure onset; she was unresponsive, exhibited strong resistance to forced eye-opening, scored positive in arm-drop and knee-standing tests, and exhibited a bilateral flexor plantar response. After the physician exited the room, urinary incontinence occurred, and she gradually regained full consciousness.</p><p>The patient's PNES likely stemmed from psychological stressors, such as maternal abuse and school difficulties. Addressing such underlying issues—through sustained psychiatric care, trauma-informed therapy, and social support—may be crucial not only for reducing PNES frequency but also for achieving long-term psychological stabilization.</p><p>PNESs have a prevalence of 2–33 per 100,000, whereas epilepsy affects approximately 0.5%–1% of the population.<span><sup>1</sup></span> Unlike epilepsy, PNES are not caused by neuronal hypersynchrony or cerebral hypoperfusion but rather by complex neuropsychiatric mechanisms.<span><sup>2</sup></span> Nonetheless, their semiology often mimics that of epileptic seizures, leading to misdiagnosis in 20%–30% of cases.<span><sup>3</sup></span> Symptoms such as foaming at the mouth and urinary incontinence—observed in this case—are typically associated with generalized tonic–clonic seizures. In epilepsy, foaming is thought to result from hypersalivation and clonic breathing<span><sup>3</sup></span>; however, the mechanism behind this phenomenon in PNES remains unclear and warrants further investigation. This case contributes to the limited literature on such rare PNES manifestations and may serve as a reference for future research.</p><p>VEEG remains the gold standard for distinguishing PNES from epilepsy, although the likelihood of capturing an event during monitoring is only
{"title":"Foaming at the mouth: A case of psychogenic nonepileptic seizure","authors":"Satoshi Saito MD, Go Taniguchi MD, PhD","doi":"10.1002/jgf2.70053","DOIUrl":"https://doi.org/10.1002/jgf2.70053","url":null,"abstract":"<p>The patient is a 19-year-old female with a history of tonic–clonic seizures. Treatment with valproic acid (VPA) began at age 3 and was discontinued upon achieving seizure freedom at age 10. At age 14, she experienced maternal abuse and school difficulties, followed by episodes of collapse and unresponsiveness, sometimes with foaming at the mouth and small shaking, lasting up to an hour. She was diagnosed with a dissociative disorder at a psychiatric clinic. At age 17, she was admitted to the emergency room for a similar seizure and began treatment for epilepsy with levetiracetam and VPA. At age 19, she underwent video electroencephalography (VEEG) to address persistent intractable seizures.</p><p>After discontinuation of antiepileptic medications, VEEG was performed over 4 days. On day 2, a psychogenic nonepileptic seizure (PNES) was recorded. Although lying in bed and stating she felt “sick,” she abruptly exhibited bilateral shoulder twitching, unresponsiveness, and foaming at the mouth, but lacked tonic posturing, cyanosis, or oxygen desaturation, with her eyes remaining closed (Figure 1A). The EEG showed a normal posterior-dominant rhythm (9–10 Hz) without epileptiform activity (Figure 1B). The physician examined her 5 min after seizure onset; she was unresponsive, exhibited strong resistance to forced eye-opening, scored positive in arm-drop and knee-standing tests, and exhibited a bilateral flexor plantar response. After the physician exited the room, urinary incontinence occurred, and she gradually regained full consciousness.</p><p>The patient's PNES likely stemmed from psychological stressors, such as maternal abuse and school difficulties. Addressing such underlying issues—through sustained psychiatric care, trauma-informed therapy, and social support—may be crucial not only for reducing PNES frequency but also for achieving long-term psychological stabilization.</p><p>PNESs have a prevalence of 2–33 per 100,000, whereas epilepsy affects approximately 0.5%–1% of the population.<span><sup>1</sup></span> Unlike epilepsy, PNES are not caused by neuronal hypersynchrony or cerebral hypoperfusion but rather by complex neuropsychiatric mechanisms.<span><sup>2</sup></span> Nonetheless, their semiology often mimics that of epileptic seizures, leading to misdiagnosis in 20%–30% of cases.<span><sup>3</sup></span> Symptoms such as foaming at the mouth and urinary incontinence—observed in this case—are typically associated with generalized tonic–clonic seizures. In epilepsy, foaming is thought to result from hypersalivation and clonic breathing<span><sup>3</sup></span>; however, the mechanism behind this phenomenon in PNES remains unclear and warrants further investigation. This case contributes to the limited literature on such rare PNES manifestations and may serve as a reference for future research.</p><p>VEEG remains the gold standard for distinguishing PNES from epilepsy, although the likelihood of capturing an event during monitoring is only","PeriodicalId":51861,"journal":{"name":"Journal of General and Family Medicine","volume":"26 6","pages":"650-651"},"PeriodicalIF":2.3,"publicationDate":"2025-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jgf2.70053","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145436440","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}