Pub Date : 2022-09-08DOI: 10.5604/01.3001.0015.9778
Karolina Goroszkiewicz, G. Lisowska, Natalia Zięba, G. Stryjewska-Makuch, K. Szopińska, M. Misiołek
Introduction: Since the beginning of 2020, the COVID-19 pandemic has been one of the biggest medical challenges. Observations of patients worldwide suggest differences in the severity of the disease depending on demographic and epidemiological factors. Aim: The aim of the study was to identify demographic factors that may affect the course of COVID-19. Material and methods: The study included 337 patients who had been infected with COVID-19 from December 2020 to June 2021. A retrospective survey containing questions about gender, age, BMI, blood group, smoking, comorbidities, and the course of SARS-CoV-2 infection was conducted. Statistical analysis was performed. Results: Older patients declared that the course of the disease was more burdensome. Comorbid oncological diseases contributed to the longer course of COVID-19. On average, women reported one symptom more than men. Patients with type 2 diabetes reported an average of 1.6 symptoms less; olfactory dysfunction and headaches were less frequent in this group. Olfactory dysfunction was more common in younger patients. Conclusion: Particular attention needs to be paid to elderly patients due to the greater
{"title":"The impact of demographic factors on the course\u0000of COVID-19 infection","authors":"Karolina Goroszkiewicz, G. Lisowska, Natalia Zięba, G. Stryjewska-Makuch, K. Szopińska, M. Misiołek","doi":"10.5604/01.3001.0015.9778","DOIUrl":"https://doi.org/10.5604/01.3001.0015.9778","url":null,"abstract":"Introduction: Since the beginning of 2020, the COVID-19 pandemic has been one of the biggest medical challenges. Observations of patients worldwide suggest differences in the severity of the disease depending on demographic and epidemiological factors. Aim: The aim of the study was to identify demographic factors that may affect the course of COVID-19. Material and methods: The study included 337 patients who had been infected with COVID-19 from December 2020 to June 2021. A retrospective survey containing questions about gender, age, BMI, blood group, smoking, comorbidities, and the course of SARS-CoV-2 infection was conducted. Statistical analysis was performed. Results: Older patients declared that the course of the disease was more burdensome. Comorbid oncological diseases contributed to the longer course of COVID-19. On average, women reported one symptom more than men. Patients with type 2 diabetes reported an average of 1.6 symptoms less; olfactory dysfunction and headaches were less frequent in this group. Olfactory dysfunction was more common in younger patients. Conclusion: Particular attention needs to be paid to elderly patients due to the greater\u0000\u0000","PeriodicalId":52362,"journal":{"name":"Polish Otorhinolaryngology Review","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71287136","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-06-30DOI: 10.5604/01.3001.0015.9097
Jan Ziemliński, Alicja Boniukiewicz, Marcin Braun, Dawid Zagacki, D. Kaczmarczyk
Introduction: Adenoid cystic carcinoma (ACC) is a rare malignancy originating from the salivary glands. It accounts for about 1–5% of all malignancies in the head and neck region. It was first described in 1853 and 1854. The main prognostic factors are tumor extension, degree of malignancy, lymph node metastases, infiltration of neural tissue and the margin of healthy tissues. Actinomycosis is a specific inflammation caused by gram-positive anaerobic bacteria Actinomyces israelii. It was first described by Von Hacker in 1885. These bacteria co-create the bacterial flora of the oral cavity, throat, digestive tract and genitourinary system. Infection with this pathogen triggers formation of abscesses and fistulas. Case report: A case of a 75-year-old woman treated for ACC is presented. During the follow-up examination, the patient presented symptoms of a local recurrence of ACC, which was suspected until the second histopathological examination that pointed to actinomycosis of the right maxillary sinus. Conclusion: Due to frequent recurrences of ACC after treatment, follow-up in these patients should be long-term, and any worrying symptoms should be diagnosed for potential recurrence.
{"title":"Actinomycosis of the right maxillary sinus mimicking the recurrence of adenoid cystic carcinoma – case presentation","authors":"Jan Ziemliński, Alicja Boniukiewicz, Marcin Braun, Dawid Zagacki, D. Kaczmarczyk","doi":"10.5604/01.3001.0015.9097","DOIUrl":"https://doi.org/10.5604/01.3001.0015.9097","url":null,"abstract":"Introduction: Adenoid cystic carcinoma (ACC) is a rare malignancy originating from the salivary glands. It accounts for about 1–5% of all malignancies in the head and neck region. It was first described in 1853 and 1854. The main prognostic factors are tumor extension, degree of malignancy, lymph node metastases, infiltration of neural tissue and the margin of healthy tissues. Actinomycosis is a specific inflammation caused by gram-positive anaerobic bacteria Actinomyces israelii. It was first described by Von Hacker in 1885. These bacteria co-create the bacterial flora of the oral cavity, throat, digestive tract and genitourinary system. Infection with this pathogen triggers formation of abscesses and fistulas. Case report: A case of a 75-year-old woman treated for ACC is presented. During the follow-up examination, the patient presented symptoms of a local recurrence of ACC, which was suspected until the second histopathological examination that pointed to actinomycosis of the right maxillary sinus. Conclusion: Due to frequent recurrences of ACC after treatment, follow-up in these patients should be long-term, and any worrying symptoms should be diagnosed for potential recurrence.\u0000\u0000","PeriodicalId":52362,"journal":{"name":"Polish Otorhinolaryngology Review","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71286610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-06-30DOI: 10.5604/01.3001.0015.8972
E. Brożek-Mądry, Z. Steć, Z. Burska, W. Wadowski, A. Krzeski
Aim: Development of an effective method of rinsing the nasal cavities and paranasal sinuses using the Zatoxin Rinse kit. Material and methods: In order to develop recommendations for rinsing the nasal cavities, a cadaver head specimen from Poznań Lab was used. The nasal cavities were rinsed with a methylene blue solution - 0.8 ml of 10% methylene blue in 240 ml of water. Rinsing was performed in the standard recommended position - the head tilted slightly forward (approx. 20–30 degrees) and to the side – approx. 45 degrees. After endoscopic examination, endoscopic surgery of the paranasal sinuses was performed and the staining of the mucosa of the paranasal sinuses was assessed. The nasal cavities were rinsed again with a solution of water and methylene blue in the head position as described above. Endoscopic examination was performed with the assessment of the staining of the nasal mucosa and paranasal sinuses, and the rinsing was repeated with the head tilted forward to 60 degrees and laterally to 45 degrees. The staining of the mucosa was recorded during the endoscopic examination. Results: The nasal rinsing performed allowed the fluid to flow along the turbinates into the nasopharyngeal region and then out. After opening the paranasal sinuses, it turned out that only a small amount of methylene blue had penetrated into the maxillary sinuses; There was also no staining of the mucosa within the ethmoid cells, the frontal sinus or the sphenoid sinus. Rinsing the nasal cavities again in the same position, but after the ethmoidectomy, showed poor penetration of methylene blue into the ethmoid region, the frontal sinus ostium and the sphenoid sinus ostium. The re-rinsing of the nasal cavities with the head tilted forward by at least 60 degrees and to the side by 45 degrees resulted in a stronger staining of the rush top and the staining of the entrance to the frontal sinus with methylene blue. Conclusions: The way the head is positioned when using Zatoxin Rinse should be adapted to the disease, and in the case of surgical treatment, to the type of surgery performed and to which sinuses are affected by the disease, so that the solution reaches the required regions.
{"title":"How to rinse the nasal cavities?","authors":"E. Brożek-Mądry, Z. Steć, Z. Burska, W. Wadowski, A. Krzeski","doi":"10.5604/01.3001.0015.8972","DOIUrl":"https://doi.org/10.5604/01.3001.0015.8972","url":null,"abstract":"Aim: Development of an effective method of rinsing the nasal cavities and paranasal sinuses using the Zatoxin Rinse kit.\u0000Material and methods: In order to develop recommendations for rinsing the nasal cavities, a cadaver head specimen from Poznań Lab was used. The nasal cavities were rinsed with a methylene blue solution - 0.8 ml of 10% methylene blue in 240 ml of water. Rinsing was performed in the standard recommended position - the head tilted slightly forward (approx. 20–30 degrees) and to the side – approx. 45 degrees. After endoscopic examination, endoscopic surgery of the paranasal sinuses was performed and the staining of the mucosa of the paranasal sinuses was assessed. The nasal cavities were rinsed again with a solution of water and methylene blue in the head position as described above. Endoscopic examination was performed with the assessment of the staining of the nasal mucosa and paranasal sinuses, and the rinsing was repeated with the head tilted forward to 60 degrees and laterally to 45 degrees. The staining of the mucosa was recorded during the endoscopic examination.\u0000Results: The nasal rinsing performed allowed the fluid to flow along the turbinates into the nasopharyngeal region and then out. After opening the paranasal sinuses, it turned out that only a small amount of methylene blue had penetrated into the maxillary sinuses; There was also no staining of the mucosa within the ethmoid cells, the frontal sinus or the sphenoid sinus. Rinsing the nasal cavities again in the same position, but after the ethmoidectomy, showed poor penetration of methylene blue into the ethmoid region, the frontal sinus ostium and the sphenoid sinus ostium. The re-rinsing of the nasal cavities with the head tilted forward by at least 60 degrees and to the side by 45 degrees resulted in a stronger staining of the rush top and the staining of the entrance to the frontal sinus with methylene blue.\u0000Conclusions: The way the head is positioned when using Zatoxin Rinse should be adapted to the disease, and in the case of surgical treatment, to the type of surgery performed and to which sinuses are affected by the disease, so that the solution reaches the required regions.\u0000\u0000","PeriodicalId":52362,"journal":{"name":"Polish Otorhinolaryngology Review","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71286684","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-06-30DOI: 10.5604/01.3001.0015.8172
W. Wadowski, E. Brożek-Mądry, Adrian Kawecki, A. Krzeski
Tuberculous otitis media is not a common disease, especially in developed countries. Its low incidence and manifestation mimicking other diseases often results with delayed diagnosis and wrong treatment. A 29-year-old women presented to ENT department with history of bilateral acute otitis media not responding to regular treatment. Multiple tympanic membrane perforations noticed in the course of disease suggested tuberculosis. To confirm the diagnosis multiple examinations were performed: Quantiferon Test, traditional culture of Mycobacterium tuberculosis and genetic test. The patient responded well to anti-TBC treatment, however some of the damages done are irreversible and some requires adequate reconstructional treatment. This case emphasize that it is important to remain watchful, as tubercoulous otits media is often misdiagnosed. Proper early diagnosis may prevent further damage as chemotherapy is usually very effective and in most cases complete healing is achieved.
{"title":"Bilateral tuberculous otitis media – case report","authors":"W. Wadowski, E. Brożek-Mądry, Adrian Kawecki, A. Krzeski","doi":"10.5604/01.3001.0015.8172","DOIUrl":"https://doi.org/10.5604/01.3001.0015.8172","url":null,"abstract":"Tuberculous otitis media is not a common disease, especially in developed countries. Its low incidence and manifestation mimicking other diseases often results with delayed diagnosis and wrong treatment. A 29-year-old women presented to ENT department with history of bilateral acute otitis media not responding to regular treatment. Multiple tympanic membrane perforations noticed in the course of disease suggested tuberculosis. To confirm the diagnosis multiple examinations were performed: Quantiferon Test, traditional culture of Mycobacterium tuberculosis and genetic test. The patient responded well to anti-TBC treatment, however some of the damages done are irreversible and some requires adequate reconstructional treatment. This case emphasize that it is important to remain watchful, as tubercoulous otits media is often misdiagnosed. Proper early diagnosis may prevent further damage as chemotherapy is usually very effective and in most cases complete healing is achieved.\u0000\u0000","PeriodicalId":52362,"journal":{"name":"Polish Otorhinolaryngology Review","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47693346","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-06-30DOI: 10.5604/01.3001.0015.8704
D. Kaczmarczyk, Alicja Boniukiewicz, Dawid Zagacki
Introduction: Diffuse large B-cell lymphoma (DLBCL) is a non-homogenous group of neoplasms of the lymphatic system in terms of morphology, genetics, and clinical aspects. The follow-up of patients treated for lymphoma includes the following examinations: clinical, laboratory, and imaging. According to the recommendation of the National Comprehensive Cancer Network (NCCN) from 2020, the observation of patients with DLBCL is mostly based on the PET/CT examination with 18F-FDG, especially when suspecting the extranodal lymphoma recurrence. Aim: The aim of the study was to define the predictive value of the PET/CT examination in the evaluation of the recurrence of DLBCL in the palatine tonsils. Material and methods: The analysis of the medical documentation of patients treated in our Department was performed. Research material included patients with suspicion of local recurrence of DLBCL in the palatine tonsils. Thirty-three patients were included in the study: 22 women and 11 men. The age range was 23–73 years with a mean of 53 years. Results: The confirmation of the local recurrence of DLBCL in the histological examination was obtained in 11 patients – 7 women and 4 men aged 58–73 years (μ= 65.4). SUVmax in the palatine tonsil in those patients ranged: for the right tonsil 3.6–9.5 (μ=6.0), and for the left tonsil 3.8–9.5 (μ = 6.1). The second group of the patients did not present any local recurrence of DLBCL in the palatine tonsils. The histological diagnosis was chronic tonsillitis. The age of those patients ranged from 23 up to 73 years (μ = 43.1 years). SUVmax ranged: for the right palatine tonsil 2.8-27.7 (μ = 8.62), for the left palatine tonsil 3.8–27.4 (μ = 8.60). The sensitivity of PET/CT in the recurrence assessment in our study was 100%, while the specificity was 33.3%. The additional predictive value was 0.33.
{"title":"PET/CT diagnostic value in suspicion of palatine tonsils’ lymphoma recurrence","authors":"D. Kaczmarczyk, Alicja Boniukiewicz, Dawid Zagacki","doi":"10.5604/01.3001.0015.8704","DOIUrl":"https://doi.org/10.5604/01.3001.0015.8704","url":null,"abstract":"Introduction: Diffuse large B-cell lymphoma (DLBCL) is a non-homogenous group of neoplasms of the lymphatic system in terms of morphology, genetics, and clinical aspects. The follow-up of patients treated for lymphoma includes the following examinations: clinical, laboratory, and imaging. According to the recommendation of the National Comprehensive Cancer Network (NCCN) from 2020, the observation of patients with DLBCL is mostly based on the PET/CT examination with 18F-FDG, especially when suspecting the extranodal lymphoma recurrence. Aim: The aim of the study was to define the predictive value of the PET/CT examination in the evaluation of the recurrence of DLBCL in the palatine tonsils. Material and methods: The analysis of the medical documentation of patients treated in our Department was performed. Research material included patients with suspicion of local recurrence of DLBCL in the palatine tonsils. Thirty-three patients were included in the study: 22 women and 11 men. The age range was 23–73 years with a mean of 53 years. Results: The confirmation of the local recurrence of DLBCL in the histological examination was obtained in 11 patients – 7 women and 4 men aged 58–73 years (μ= 65.4). SUVmax in the palatine tonsil in those patients ranged: for the right tonsil 3.6–9.5 (μ=6.0), and for the left tonsil 3.8–9.5 (μ = 6.1). The second group of the patients did not present any local recurrence of DLBCL in the palatine tonsils. The histological diagnosis was chronic tonsillitis. The age of those patients ranged from 23 up to 73 years (μ = 43.1 years). SUVmax ranged: for the right palatine tonsil 2.8-27.7 (μ = 8.62), for the left palatine tonsil 3.8–27.4 (μ = 8.60). The sensitivity of PET/CT in the recurrence assessment in our study was 100%, while the specificity was 33.3%. The additional predictive value was 0.33.\u0000\u0000","PeriodicalId":52362,"journal":{"name":"Polish Otorhinolaryngology Review","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71286548","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-06-14DOI: 10.5604/01.3001.0015.8769
Michał Kaszak, Thomas Wow, Daria Kaszak, Agnieszka Kolacinska-Wow
Introduction: Liquid biopsy becomes usefulness in many types of cancers. Cell free DNA (CfDNA) contains DNA released physiologically and pathologically from cells to body fluids. Liquid biopsy allows to search and evaluate DNA in blood, saliva, urine etc. Development of this method can provide more precise, personalisation of oncological therapy. Head and neck cancers (HNC) are responsible for 350 000 deaths yearly worldwide. Head and neck squamous cell carcinoma (HNSCC) is most common HNC type-about 90% cases. HNSCC is often diagnosed in advanced disease stages what is associated with poor survival. Aim: The intention of this systematic review was to compare papers which used liquid biopsy of circulating free DNA in detection and therapy of head and neck cancers. Methods: Articles from last 7 years in Pubmed and Google Scholar base were searched. Results: We found 16 articles fulfilling criteria. Discussion: Level of CfDNA depends of cancer occurrence, its advancements. The higher the stage of the disease, the higher the levels of CfDNA and tumor DNA in it. Detectable CfDNA after chemo or radiotherapy may predict recurrence, Heterogeneity of HNC was demonstrated, bigger than other cancers. Alternations in TP53 and PIK3CA were most common through included studies. Human Papillomavirus DNA disclosure in CfDNA have valuable specificity and show similar properties as tumor DNA. Studies showed that saliva is equally good material in liquid biopsy as a blood, especially in oral cancers. Conclusion: Results are promising but showed limitations. Future research should be more standardized, include more cases and compare treatments methods.
{"title":"Circulating free DNA in head and neck cancer – a systematic\u0000review","authors":"Michał Kaszak, Thomas Wow, Daria Kaszak, Agnieszka Kolacinska-Wow","doi":"10.5604/01.3001.0015.8769","DOIUrl":"https://doi.org/10.5604/01.3001.0015.8769","url":null,"abstract":"Introduction: Liquid biopsy becomes usefulness in many types of cancers. Cell free DNA (CfDNA) contains DNA released\u0000physiologically and pathologically from cells to body fluids. Liquid biopsy allows to search and evaluate DNA in blood, saliva,\u0000urine etc. Development of this method can provide more precise, personalisation of oncological therapy. Head and neck\u0000cancers (HNC) are responsible for 350 000 deaths yearly worldwide. Head and neck squamous cell carcinoma (HNSCC) is\u0000most common HNC type-about 90% cases. HNSCC is often diagnosed in advanced disease stages what is associated with\u0000poor survival.\u0000Aim: The intention of this systematic review was to compare papers which used liquid biopsy of circulating free DNA in\u0000detection and therapy of head and neck cancers.\u0000Methods: Articles from last 7 years in Pubmed and Google Scholar base were searched.\u0000Results: We found 16 articles fulfilling criteria.\u0000Discussion: Level of CfDNA depends of cancer occurrence, its advancements. The higher the stage of the disease, the higher the\u0000levels of CfDNA and tumor DNA in it. Detectable CfDNA after chemo or radiotherapy may predict recurrence, Heterogeneity\u0000of HNC was demonstrated, bigger than other cancers. Alternations in TP53 and PIK3CA were most common through included\u0000studies. Human Papillomavirus DNA disclosure in CfDNA have valuable specificity and show similar properties as tumor\u0000DNA. Studies showed that saliva is equally good material in liquid biopsy as a blood, especially in oral cancers.\u0000Conclusion: Results are promising but showed limitations. Future research should be more standardized, include more cases\u0000and compare treatments methods.\u0000\u0000","PeriodicalId":52362,"journal":{"name":"Polish Otorhinolaryngology Review","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71286212","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-06-09DOI: 10.5604/01.3001.0015.8738
M. Jeziorny, M. Fraczek
Surgical correction of the nasal septum in childhood remains a controversial issue. Due to concerns that destruction of growth zones in the trapezius cartilage during the procedure may have a significant impact on the later growth of the nose and facial part of cranium, for many years ENT specialists approached the issue of septoplasty in children in a very conservative manner. However, many more recent reports indicate that a conservatively and correctly performed procedure does not pose a threat to the development of the nose and can be safely performed in children with severe septal deviation after 5–6 years of age. In case of the coexistence of deformities in the shape of the external nose, it is recommended to simultaneously correct it, which guarantees an optimal final result. These age restrictions do not apply to urgent cases, such as inter alia: septal hematoma and abscess, tumors and developmental disorders. Most importantly, no or sparing (with preservation of cartilage growth centers) resection of the quadrangular cartilage is essential to avoid nasal growth disorder. Rhinoplasties have been reported to have a higher rate of repair and lower patient aesthetic satisfaction. The decision if to perform surgical treatment and its scope should be made after analyzing the potential benefits and consequences on the one hand and leaving a deviated septum on the other hand. In case of doubt, the operation should be postponed until the end of puberty.
{"title":"Septoplasty and septorhinoplasty in children","authors":"M. Jeziorny, M. Fraczek","doi":"10.5604/01.3001.0015.8738","DOIUrl":"https://doi.org/10.5604/01.3001.0015.8738","url":null,"abstract":"Surgical correction of the nasal septum in childhood remains a controversial issue. Due to concerns that destruction of growth zones in the trapezius cartilage during the procedure may have a significant impact on the later growth of the nose and facial part of cranium, for many years ENT specialists approached the issue of septoplasty in children in a very conservative manner. However, many more recent reports indicate that a conservatively and correctly performed procedure does not pose a threat to the development of the nose and can be safely performed in children with severe septal deviation after 5–6 years of age. In case of the coexistence of deformities in the shape of the external nose, it is recommended to simultaneously correct it, which guarantees an optimal final result. These age restrictions do not apply to urgent cases, such as inter alia: septal hematoma and abscess, tumors and developmental disorders. Most importantly, no or sparing (with preservation of cartilage growth centers) resection of the quadrangular cartilage is essential to avoid nasal growth disorder. Rhinoplasties have been reported to have a higher rate of repair and lower patient aesthetic satisfaction. The decision if to perform surgical treatment and its scope should be made after analyzing the potential benefits and consequences on the one hand and leaving a deviated septum on the other hand. In case of doubt, the operation should be postponed until the end of puberty.\u0000\u0000","PeriodicalId":52362,"journal":{"name":"Polish Otorhinolaryngology Review","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71286190","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-06-03DOI: 10.5604/01.3001.0015.8690
Małgorzata Bolek-Górska, P. Potocki
Aim: The aim of our study is to describe the case of a patient suffering from squamous cell carcinoma of the basaloid nasal cavity, who achieved complete recurrence remission after palliative radiotherapy. Case report: We present a clinical case of a patient suffering from basaloid squamous cell carcinoma of the nasal cavity who achie-ved a complete remission of local recurrence following a palliative radiotherapy. In November 2011 the patient underwent a radical, block resection of the tumor withing the nasal cavity and right paranasal sinuses, with margin sampling. The recurrence occurred in June 2012. As she did not qualify for rescue therapy, she received 2 courses of radiation, spaced 6 months apart – 20 Gy in 5 fractions each. A complete remission lasting until 2016 was achieved. Progression free survival from the first series of palliative radiotherapy was 45 months. Overall survival since the diagnosis was 69 months (62 months since the recurrence was diagnosed). Discussion: We have conducted a literature review regarding therapeutic options and prognosis and compared it with our case. Basaloid squamous cancer is more aggressive than other squamous cancers. Previous case studies and case series descri-be this type of the disease being treated with surgery, radiation or various multimodality protocols including chemoradiation, surgery followed by radiation and others. Conclusions: A conclusion was drawn that the best results were reported in studies which based their therapeutic strategy on radiotherapy.
{"title":"Complete remission after radiotherapy in a patient with basaloid squamous cell cancer of the nasal cavity and maxillary sinus – case report and review of literature","authors":"Małgorzata Bolek-Górska, P. Potocki","doi":"10.5604/01.3001.0015.8690","DOIUrl":"https://doi.org/10.5604/01.3001.0015.8690","url":null,"abstract":"Aim: The aim of our study is to describe the case of a patient suffering from squamous cell carcinoma of the basaloid nasal cavity, who achieved complete recurrence remission after palliative radiotherapy. Case report: We present a clinical case of a patient suffering from basaloid squamous cell carcinoma of the nasal cavity who achie-ved a complete remission of local recurrence following a palliative radiotherapy. In November 2011 the patient underwent a radical, block resection of the tumor withing the nasal cavity and right paranasal sinuses, with margin sampling. The recurrence occurred in June 2012. As she did not qualify for rescue therapy, she received 2 courses of radiation, spaced 6 months apart – 20 Gy in 5 fractions each. A complete remission lasting until 2016 was achieved. Progression free survival from the first series of palliative radiotherapy was 45 months. Overall survival since the diagnosis was 69 months (62 months since the recurrence was diagnosed). Discussion: We have conducted a literature review regarding therapeutic options and prognosis and compared it with our case. Basaloid squamous cancer is more aggressive than other squamous cancers. Previous case studies and case series descri-be this type of the disease being treated with surgery, radiation or various multimodality protocols including chemoradiation, surgery followed by radiation and others. Conclusions: A conclusion was drawn that the best results were reported in studies which based their therapeutic strategy on radiotherapy.\u0000\u0000","PeriodicalId":52362,"journal":{"name":"Polish Otorhinolaryngology Review","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71286536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-06-02DOI: 10.5604/01.3001.0015.8664
Barbara Jamróz, J. Chmielewska-Walczak, Emilia Jarosińska, K. Niemczyk
Introduction: Postoperative paresis of the laryngeal nerves may disrupt the protection function of the larynx during swallowing. Material and method: Stage 1: Retrospective analysis of FEES reports in patients with unilateral laryngeal paralysis (n = 99) in terms of the occurrence of penetration or aspiration of saliva and liquid and solid food. Stage 2: Prospective analysis of the results of the EAT-10 screening questionnaire and reports (n = 12) of FEES examination performed in the early postoperative period (up to 7 days after the surgery) in patients with iatrogenic palsy of the X cranial nerve. Assessment of: sensory of the larynx, effectiveness for cough and pressure tests, presence of "white out", PAS scale for a regular diet according to IDDSI (ST 0; ST 7). Results: Stage 1: Penetration or aspiration was found in 65% of patients, in 29% of patients it were silent symptoms. Salivary penetration or aspiration concerned 60.60% of patients. Among people who developed silent disorders, 20 had isolated n. X paralysis, and 79% - polyneuric palsy. The PAS level between 2-8 was found in 65% of patients. Stage 2: 11/12 patients obtained the result of the EAT 10 questionnaire > = 3. "White out" elongation and sensory loss were found in 75% of patients, ineffective cough in 33%. In oral trials, residue (50% ST0), premature swallowing (8% ST0), penetration (33% ST0, 8% ST7) and aspiration (16% ST0, 8% ST7) were found. Adaptive and compensatory techniques were the most frequently combined (66%), and the dominant technique was turning the head towards the affected side. Conclusions: In every sixth patient with iatrogenic laryngeal paralysis, aspiration of non-condensed fluids occurs early after the surgery, and the penetration of these contents into the larynx occurs in every third patient. It is therefore advisable to improve the comfort associated with the quality of life dependent on swallowing and to prevent complications of dysphagia in the study group. Therefore, it is justified to extend diagnostics to include clinical assessment of swallowing and qualify patients for FEES assessment. Key words: dysphagia, penetration, aspiration, laryngeal paralysis, FEES, vocal fold paresis, oropharyngeal dysphagia
{"title":"Assessment of the effectiveness of laryngeal protection mechanisms in patients with iatrogenic, unilateral laryngeal paralysis","authors":"Barbara Jamróz, J. Chmielewska-Walczak, Emilia Jarosińska, K. Niemczyk","doi":"10.5604/01.3001.0015.8664","DOIUrl":"https://doi.org/10.5604/01.3001.0015.8664","url":null,"abstract":"Introduction:\u0000Postoperative paresis of the laryngeal nerves may disrupt the protection function of the larynx during swallowing.\u0000Material and method:\u0000Stage 1: Retrospective analysis of FEES reports in patients with unilateral laryngeal paralysis (n = 99) in terms of the occurrence of penetration or aspiration of saliva and liquid and solid food. Stage 2: Prospective analysis of the results of the EAT-10 screening questionnaire and reports (n = 12) of FEES examination performed in the early postoperative period (up to 7 days after the surgery) in patients with iatrogenic palsy of the X cranial nerve. Assessment of: sensory of the larynx, effectiveness for cough and pressure tests, presence of \"white out\", PAS scale for a regular diet according to IDDSI (ST 0; ST 7).\u0000Results:\u0000Stage 1: Penetration or aspiration was found in 65% of patients, in 29% of patients it were silent symptoms. Salivary penetration or aspiration concerned 60.60% of patients. Among people who developed silent disorders, 20 had isolated n. X paralysis, and 79% - polyneuric palsy. The PAS level between 2-8 was found in 65% of patients. Stage 2: 11/12 patients obtained the result of the EAT 10 questionnaire > = 3. \"White out\" elongation and sensory loss were found in 75% of patients, ineffective cough in 33%. In oral trials, residue (50% ST0), premature swallowing (8% ST0), penetration (33% ST0, 8% ST7) and aspiration (16% ST0, 8% ST7) were found. Adaptive and compensatory techniques were the most frequently combined (66%), and the dominant technique was turning the head towards the affected side.\u0000Conclusions: \u0000In every sixth patient with iatrogenic laryngeal paralysis, aspiration of non-condensed fluids occurs early after the surgery, and the penetration of these contents into the larynx occurs in every third patient. It is therefore advisable to improve the comfort associated with the quality of life dependent on swallowing and to prevent complications of dysphagia in the study group. Therefore, it is justified to extend diagnostics to include clinical assessment of swallowing and qualify patients for FEES assessment.\u0000Key words: dysphagia, penetration, aspiration, laryngeal paralysis, FEES, vocal fold paresis, oropharyngeal dysphagia\u0000\u0000","PeriodicalId":52362,"journal":{"name":"Polish Otorhinolaryngology Review","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47175331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-06-02DOI: 10.5604/01.3001.0015.8538
Katarzyna Czerwaty, W. Miechowski, Izabella Godlewska, Karolina Dżaman
Biological treatment is a modern method of therapy that has recently found its application in the treatment of type 2 chronic rhinosinusitis (CRS) associated with eosinophilic inflammation and the Th2-dependent inflammatory reaction (involving interleukins 4, 5 and 13). The aim of the article is to present the current state of knowledge regarding the use of biological treatment as a new therapeutic option for patients with treatment-resistant CRS with nasal polyps. Biologics are monoclonal antibodies that help suppress abnormal responses by the immune system. They are widely used in neoplastic, inflammatory and allergic diseases. Currently, biological drugs can also be used in patients with CRS and include monoclonal antibodies directed against interleukin 4 receptors (dupilumab), interleukin 5 (benralizumab) and directly blocking interleukin 5 itself (mepolizumab, reslizumab) or free immunoglobulin E (omalizumab). In 2019, the U.S. Food and Drug Administration (FDA) and the European Medicines Agency (EMA) approved dupilumab for the treatment of CRS with nasal polyps. In Poland, none of the biological drugs has been included in the refunded list in the CRS treatment, and the high costs of treatment limit the possibility of using this therapeutic option by the majority of patients.
{"title":"Biological treatment in chronic rhinosinusitis: the current state of knowledge","authors":"Katarzyna Czerwaty, W. Miechowski, Izabella Godlewska, Karolina Dżaman","doi":"10.5604/01.3001.0015.8538","DOIUrl":"https://doi.org/10.5604/01.3001.0015.8538","url":null,"abstract":"Biological treatment is a modern method of therapy that has recently found its application in the treatment of type 2 chronic rhinosinusitis (CRS) associated with eosinophilic inflammation and the Th2-dependent inflammatory reaction (involving interleukins 4, 5 and 13). The aim of the article is to present the current state of knowledge regarding the use of biological treatment as a new therapeutic option for patients with treatment-resistant CRS with nasal polyps. Biologics are monoclonal antibodies that help suppress abnormal responses by the immune system. They are widely used in neoplastic, inflammatory and allergic diseases. Currently, biological drugs can also be used in patients with CRS and include monoclonal antibodies directed against interleukin 4 receptors (dupilumab), interleukin 5 (benralizumab) and directly blocking interleukin 5 itself (mepolizumab, reslizumab) or free immunoglobulin E (omalizumab). In 2019, the U.S. Food and Drug Administration (FDA) and the European Medicines Agency (EMA) approved dupilumab for the treatment of CRS with nasal polyps. In Poland, none of the biological drugs has been included in the refunded list in the CRS treatment, and the high costs of treatment limit the possibility of using this therapeutic option by the majority of patients.\u0000\u0000","PeriodicalId":52362,"journal":{"name":"Polish Otorhinolaryngology Review","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71286635","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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