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Rola asymetrycznego wzmocnienia kontrastowego ucha wewnętrznego w badaniu MRI w diagnostyce choroby Ménière’a - opis przypadku 不对称内耳造影增强在Ménière病诊断中的作用
Q4 Medicine Pub Date : 2023-01-25 DOI: 10.5604/01.3001.0016.2304
Agnieszka Jasińska-Nowacka, Katarzyna Pierchała, Emil Wnuk, K. Niemczyk
Wstęp: Choroba Ménière’a charakteryzuje się występowaniem napadowych zawrotów głowy z towarzyszącym szumem usznym i uczuciem pełności w uchu oraz fluktuacyjnym niedosłuchem odbiorczym. Stanowi istotną przyczynę zawrotów głowy, spotykaną w gabinetach lekarzy otolaryngologów, neurologów i lekarzy podstawowej opieki zdrowotnej. Rozwój technik diagnostyki obrazowej, w tym badanie rezonansu magnetycznego (MRI) ucha wewnętrznego, pozwala obecnie na przyżyciowe stwierdzenie wodniaka endolimfatycznego, uważanego za podłoże choroby. Z uwagi na nieznaną etiologię leczenie choroby Ménière’a jest przede wszystkim objawowe. Aktualne międzynarodowe wytyczne ds. diagnostyki i leczenia choroby Meniere’a, zalecają terapię eskalacyjną, rozpoczynającą się od leczenia zachowawczego, a zwieńczoną metodami chirurgicznymi proponowanymi pacjentom z agresywnym przebiegu choroby. Miarą skuteczności leczenia jest redukcja liczby ataków wirowych zawrotów głowy, uważanych za najbardziej uciążliwy aspekt schorzenia. Opis przypadkuPrzedstawiono przypadek pacjenta z jednostronną zdefiniowaną chorobą Ménière’a o zaawansowanym przebiegu klinicznym, u którego w badaniu MRI nie stwierdzono obecności wodniaka endolimfatycznego, a jedynie wzrost wysycenia kontrastowego ślimaka po stronie występowania objawów. Pacjent został zakwalifikowany do operacji neurektomii przedsionkowej z dostępu przez środkowy dół czaszki. Leczenie operacyjne skutkowało całkowitym ustąpieniem zawrotów głowy. W kontrolnym badaniu, wykonanym osiem miesięcy po operacji przecięcia nerwu przedsionkowego z dostępu przez środkowy dół czaszki, stwierdzono istotne zmniejszenie zakontrastowania ucha operowanego. PodsumowanieBadanie rezonansu magnetycznego stwarza możliwość monitorowania przebiegu choroby w uchu wewnętrznym po zastosowanym leczeniu. Omówiony przypadek oraz przegląd literatury pozwalają sądzić, iż asymetryczne wzmocnienie objawowego ucha jest wczesnym radiologicznym objawem u pacjentów z chorobą Ménière’a, a wcześnie postawiona diagnoza oraz odpowiednio wdrożona terapia dają szansę na poprawę komfortu życia pacjenta, a być może także zatrzymanie patologicznych procesów zachodzących w uchu wewnętrznym.
引言:梅尼埃病的特点是癫痫发作、头晕伴耳鸣、耳朵饱胀感和波动性听力损失。它是导致头晕的重要原因,常见于耳鼻喉科医生、神经科医生和初级保健医生的办公室。诊断成像技术的发展,包括内耳的磁共振成像(MRI),目前允许对内淋巴疏水性进行存活检测,这被认为是该疾病的根本原因。由于病因不明,Ménière病的治疗主要是症状性的。目前梅尼埃病诊断和治疗的国际指南建议升级治疗,从保守治疗开始,到为侵袭性疾病患者建议的手术方法结束。衡量治疗效果的标准是减少头晕的旋风发作次数,头晕被认为是该疾病最严重的方面。病例描述一例患有单侧定义的Ménière病并有晚期临床病程的患者,其MRI研究未检测到内淋巴疏水性的存在,但仅检测到症状一侧耳蜗造影增强的增加。该患者符合通过中颅腔进行心房神经切除术的条件。手术治疗使头晕完全消失。在一项对照研究中,在从颅骨中部切断心房神经的手术后八个月进行,发现手术耳朵的对比度显著降低。磁共振成像提供了一个监测治疗后内耳疾病进程的机会。所讨论的病例和文献综述表明,有症状的耳朵不对称强化是Ménière病患者的早期放射学症状,早期诊断和适当实施的治疗为改善患者舒适度提供了机会,也可能阻止内耳发生的病理过程。
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引用次数: 0
Treatment of deafness with the use of cochlear implants in children with severe heart defects 使用人工耳蜗治疗严重心脏缺陷儿童耳聋
Q4 Medicine Pub Date : 2023-01-23 DOI: 10.5604/01.3001.0016.1566
Anna Waśniewska-Włodarczyk, W. Konopka, Małgorzata Śmiechura-Gańczarczyk
Objective: To assess the treatment of hearing loss in children with severe heart defects after cardiac surgeries in their early life. The evaluation included the preparation to the surgery, the safety and effectiveness of cochlear implantation. The study design: It was a retrospective study. In our database there are 7 children (age: 2.5-5.5) with congenital heart defect who have had cardiac surgery. All of them were implanted with a Cochlear CI512 device. Late implantation was a result of a necessity to perform life-saving cardiac surgeries. The children are still under the observation of audiologists and speech therapists.Results: Assessment of the four-frequency average of indicative free field audiometry shows that there is an increase of hearing ability within a given time period: without sound processor (SP) the threshold of hearing had been 112.75 dB, with SP (three month after surgery) it was 67.5 dB, 6 months after surgery was 49 dB. After the cochlear implantation, speech development of implanted children was faster than observed prior to cochlear implant (CI) surgery. Conclusion: Pre-operation planning reduces the risk during cochlear implantation. Cochlear implantation is safe for children with heart defects, if they are early diagnosed and treated.
目的:探讨严重心脏缺损儿童早期心脏手术后听力损失的治疗方法。评价内容包括手术准备、人工耳蜗植入术的安全性和有效性。研究设计:回顾性研究。在我们的数据库中,有7名患有先天性心脏缺陷的儿童(年龄:2.5-5.5岁)进行了心脏手术。所有患者均植入人工耳蜗CI512。由于需要进行挽救生命的心脏手术,所以植入较晚。这些孩子仍在听力学家和语言治疗师的观察下。结果:指示性自由场听力学四频平均值评估显示,在给定时间内听力能力有所提高:未使用声音处理器(SP)的听力阈值为112.75 dB,使用SP(术后3个月)的听力阈值为67.5 dB,术后6个月的听力阈值为49 dB。人工耳蜗植入术后患儿的语言发育明显快于人工耳蜗植入术前。结论:术前计划可降低人工耳蜗植入术的风险。如果有心脏缺陷的儿童得到早期诊断和治疗,人工耳蜗植入是安全的。
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引用次数: 0
Cochlear Implantation in Children with Congenital Inner Ear Malformations 先天性内耳畸形儿童人工耳蜗植入术
Q4 Medicine Pub Date : 2023-01-23 DOI: 10.5604/01.3001.0016.1567
Azzam Abbas *, Mustafa Hamed **, Ahmed Ahmed ***
AbstractBackground: Cochlear Implantation has proven beneficial in patients with profound congenital hearing impairments. Performing cochlear implantation in patients with inner ear malformation has always been a matter of dispute as congenital deaf ears may have anatomical malformations and difficulties during operation, it is important to focus on problems and complications that may face the surgeon who is performing this operation.Objective: Evaluate the problems and surgical difficulties encountered in patients with congenital inner ear malformation, who underwent cochlear implantation.Patients and methods: A series of 21 pediatric cochlear implant (CI) patients with known inner ear malformations determined on computed tomography (CT) of the temporal bone who underwent cochlear implantation in the department of otolaryngology in Hospital Martyr Ghazi Al-Hariri and AL-Yarmouk Teaching Hospital, Baghdad, Iraq, during the period from January 2018 to January 2021 were the subjects of the study to determine intraoperative adverse effects of these anomalies regarding electrode array insertion depths, predisposition to cerebrospinal fluid (CSF) leak through the cochleostomy, and associated facial nerve anomalies that can create access problems for scala tympani.Results: The most common inner ear anomalies were wide vestibular aqueduct (15) patients with percentage of (71.4%), incomplete partitions (5) patients with percentage of (23.8%), and common cavity (1) patient with percentage of (4.8%). CSF leak, the most common was CSF ooze (11) patients with percentage of (52.4%), CSF gusher seen in (6) patients (28.6%), and no CSF leak in (4) patients (19%). Facial nerve anomalies, only one case has abnormal position (more superficial and not injured) with a percentage of (4.8%), while in 20 patients (95.2%) no anomaly was detected. Electrode insertion depth, full insertion was achieved in (17) patients with percentage of (81%), while incomplete insertion was occurred in (4) patients (19%).Conclusion: Cochlear implant can be successfully and safely done in patients with selected congenital inner ear anomalies. Surgery can be challenging in certain cases of gusher and facial nerve abnormalities, but proper radiology and good surgical technique will help avoid complications. Keywords: Cochlear Implantation, Congenital inner ear malformation, facial nerve anomalies.
摘要背景:人工耳蜗植入术已被证明对重度先天性听力障碍患者有益。先天性耳聋患者在手术中可能存在解剖畸形和手术困难,因此对内耳畸形患者进行人工耳蜗植入术一直是一个有争议的问题,重要的是关注外科医生可能面临的问题和并发症。目的:探讨先天性内耳畸形患者行人工耳蜗植入术的问题及手术难点。患者及方法:本研究选取了2018年1月至2021年1月期间在伊拉克巴格达烈士医院Ghazi Al-Hariri和AL-Yarmouk教学医院耳鼻喉科接受人工耳蜗植入的21例已知内耳畸形的儿童人工耳蜗(CI)患者作为研究对象,以确定这些异常在电极阵列插入深度方面的术中不良影响。脑脊液(CSF)易通过耳蜗造口漏出,并伴有面神经异常,可造成中耳炎的通路问题。结果:最常见的内耳异常为前庭导水管宽15例(占71.4%),隔水不全5例(占23.8%),普通腔1例(占4.8%)。脑脊液渗漏,最常见的是脑脊液渗出(11例),占52.4%,脑脊液喷涌(6例)占28.6%,无脑脊液渗漏(4例)占19%。面神经异常,仅有1例有位置异常(较浅,未损伤),占(4.8%),20例(95.2%)未发现异常。电极插入深度,有17例患者完全插入,占81%,有4例患者不完全插入,占19%。结论:有选择的先天性内耳畸形患者可安全、成功地行人工耳蜗植入术。在某些涌出和面神经异常的情况下,手术可能是具有挑战性的,但适当的放射学和良好的手术技术将有助于避免并发症。关键词:人工耳蜗,先天性内耳畸形,面神经异常。
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引用次数: 0
Exercise-induced laryngeal obstruction: a rarely recognized cause of exercise-induced dyspnea. Two case reports 运动性喉部梗阻:运动性呼吸困难的罕见病因。两例报告
Q4 Medicine Pub Date : 2023-01-23 DOI: 10.5604/01.3001.0016.2237
M. Litwiniuk, Aleksandra Piechuta, Barbara Jamróz
Introduction: Exercise-induced laryngeal obstruction (EILO) is a transient and reversible narrowing of the larynx in response to intense physical effort. The clinical picture of EILO often resembles those of asthma or exercise induced bronchospasm. The gold standard in EILO diagnostics is nasofiberoscopic examination during intense exercise (CLE).Case Description: We present two clinical cases of athletes initially treated for asthma who were diagnosed with EILO after CLE. This allowed the initiation of phoniatric rehabilitation and initial improvement of exercise tolerance.
引言:运动性喉梗阻(EILO)是一种因剧烈体力劳动而导致的短暂且可逆的喉部狭窄。EILO的临床表现通常类似于哮喘或运动诱发的支气管痉挛。EILO诊断的金标准是在剧烈运动(CLE)期间进行鼻纤维镜检查。病例描述:我们报告了两例最初治疗哮喘的运动员在CLE后被诊断为EILO的临床病例。这使得开始了发音康复和运动耐受性的初步改善。
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引用次数: 0
A pyocele of a frontal sinus as a complication of a chronic sinusitis - a case report 额窦幽门膨出并发慢性鼻窦炎1例
Q4 Medicine Pub Date : 2023-01-23 DOI: 10.5604/01.3001.0016.2235
M. Król, Kacper Dykas, Patryk Hartwich, J. Szaleniec
Introduction: Pyocele is a rare complication of sinusitis that is usually associated with stenosis of the ostium of the sinus caused by inflammation, trauma.Case report: A 68-year-old woman was admitted to the Otolaryngology Clinical Department of the University Hospital in Krakow, Poland because of a tumor of the right frontal bone which was painful during palpation. In anamnesis there were the histories of previous laryngological surgeries associated with the treatment of chronic sinusitis. The conducted medical imaging presented the destruction of the walls of both the right and left frontal sinuses caused by pathological changes penetrating to the orbit and adhering to the dura mater. The clinical and radiological picture suggested the diagnosis of empyema of the paranasal sinus (pyocele). The patient was scheduled for bilateral endoscopic frontoethmoidectomy and the surgery ended without complications. Nowadays, the patient remains under follow-up in the outpatient otolaryngology clinic.Discussion: The main disease entity, which should be included in the differential diagnosis of pyocele is the retention cyst of the sinus. The vast majority of pyocele cases are caused by superinfection of a mucocele by bacteria (in the described case the bacterial culture of the lesion content revealed the presence of Citrobacter koseri). An efficient and sufficient method of treatment of pyocele of paranasal sinuses is their endoscopic drainage.Conclusion: In the diagnosis of pyocele, the most important are data from anamnesis, physical examination and results from computed tomography and magnetic resonance imaging. Treatment is mainly based on properly performed surgery, pharmacotherapy and consecutive rehabilitation. Endoscopic surgery is an effective procedure and its early use often prevents serious complications resulting from the expansion of the lesion.
幽门膨出是一种罕见的鼻窦炎并发症,通常与炎症、创伤引起的鼻窦口狭窄有关。病例报告:一名68岁妇女因右额骨肿瘤触诊时疼痛住进波兰克拉科夫大学医院耳鼻喉科临床部。在记忆中有以前的喉外科手术与慢性鼻窦炎的治疗相关的历史。影像学表现为左、右额窦壁破坏,病理改变穿透眶壁,粘附硬脑膜。临床及影像学表现提示为鼻窦脓肿(幽门膨出)。患者被安排行双侧内镜额筛切除术,手术结束无并发症。目前,患者仍在门诊耳鼻喉科接受随访。讨论:脓幽门囊肿的鉴别诊断应包括的主要疾病是窦内潴留囊肿。绝大多数幽门脓肿病例是由细菌对粘液囊肿的重复感染引起的(在本例中,病变内容物的细菌培养显示存在克塞利柠檬酸杆菌)。鼻窦内腔引流是治疗鼻窦幽门膨出的一种有效而充分的方法。结论:在脓腔膨出的诊断中,最重要的是记忆资料、体格检查以及计算机断层扫描和磁共振成像结果。治疗主要基于适当的手术、药物治疗和连续康复。内窥镜手术是一种有效的手术方法,它的早期使用通常可以防止因病变扩大而引起的严重并发症。
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引用次数: 0
Radiologic anatomy of the middleear and inner ear in computed tomography images 计算机断层扫描图像中耳和内耳的放射学解剖
Q4 Medicine Pub Date : 2023-01-23 DOI: 10.5604/01.3001.0016.2236
T. Wojciechowski
The development of imaging methods in the last twenty years and the increased availability of high-resolution CT of temporal bones make it possible to analyze the complex anatomy of the insides of the temporal bone in detail with greater accuracy than before. At the same time, advances in middle ear surgery require the surgeon to be familiar with the interpretation of imaging examinations. This approach makes it possible to select the treatment method individually for each patient. It may also contribute to reducing the risk of complications.The article presents a description of the CT examination technique along with a historical outline, as well as the interpretation of the CT examination of temporal bones together with the description of anatomical structures, Particular interest was brought on the middle ear structures and those visible in the CT examination. In addition, anatomical variants are presented that a person viewing the images obtained with this method may encounter.
近二十年来成像方法的发展和颞骨高分辨率CT的日益普及,使得对颞骨内部复杂解剖结构的详细分析比以前更加准确成为可能。同时,中耳手术的进步要求外科医生熟悉影像学检查的解释。这种方法可以为每个病人单独选择治疗方法。它还可能有助于降低并发症的风险。本文介绍了颞骨CT检查技术及其历史概况,并对颞骨CT检查及其解剖结构的描述进行了解释,重点介绍了中耳结构和CT检查中可见的结构。此外,解剖变异提出,一个人观看图像获得这种方法可能会遇到。
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引用次数: 0
Anatomical and clinical aspects and outcomes of bilateral cochlear implantation in cochlear hypoplasia type IV - a case report IV型耳蜗发育不全患者双侧人工耳蜗植入术的解剖、临床及疗效1例
Q4 Medicine Pub Date : 2023-01-23 DOI: 10.5604/01.3001.0016.2238
Agata Szleper, Magdalena Lachowska, A. Pastuszka, Zuzanna Łukaszewicz-Moszyńska, T. Wojciechowski, K. Niemczyk
Cochlear hypoplasia is a congenital inner ear malformation (IEM) characterized by a reduced external cochlear dimension, usually accompanied by an abnormal internal architecture. Type IV cochlear hypoplasia is a cochlea with hypoplastic middle and apical turns. It may occur along with dislocation of the facial nerve, associated with semicircular abnormalities, less clearly marked promontory, or stapedial fixation. Such patients can present a broad spectrum of audiological test results, from sensorineural or mixed mild or profound hearing loss. The above anatomical changes may be responsible for intraoperative difficulties during cochlear implantation. In the studied case, a 6-month-old patient was diagnosed with an inner ear malformation - cochlear hypoplasia type IV on both sides. Computed tomography with multiplanar and 3D reconstruction was performed to analyze the middle and inner ear anatomy in detail. Both types of imaging reconstruction helped decide which cochlear implant electrode to choose. Perimodiolar-positioned cochlear implant electrode was found to be the most suitable choice. The patient underwent sequential bilateral cochlear implantation with expected incomplete electrode array insertion on both sides. First repeatable auditory responses were observed two months after the second implant activation. Good parental cooperation with therapists and adequately defined developmental goals in the presented patient allowed the multidisciplinary team to take advantage of the child's intellectual abilities and choose the suitable communication method; however, the patient's auditory responses were obtained slowly. The final auditory results cannot be predicted in inner ear malformations due to abnormal anatomical structure and, thus, heterogeneous innervation within the deformed cochlea. The programming of the sound processor must be individual in each case, based on the child's behavior observation and, if possible, objective test results. Patients with cochlear malformations usually require higher stimulation intensities to obtain sound sensations than patients with a typical cochlear structure.
耳蜗发育不全是一种先天性内耳畸形(IEM),其特征是外耳蜗尺寸缩小,通常伴有内部结构异常。IV型耳蜗发育不全是指耳蜗中、尖转发育不全。它可伴面神经脱位,伴有半圆形畸形、不明显的岬或镫骨固定。此类患者可表现出广泛的听力学检查结果,从感音神经性或混合性轻度或重度听力损失。上述解剖改变可能是造成人工耳蜗植入术中困难的原因。在本病例中,一名6个月大的患儿被诊断为双侧内耳畸形- IV型耳蜗发育不全。采用计算机断层多平面三维重建对中耳和内耳解剖结构进行详细分析。两种类型的成像重建有助于决定选择哪种人工耳蜗电极。耳蜗周定位电极是最合适的选择。患者接受序贯双侧人工耳蜗植入,预计两侧电极阵列置入不完整。第一次可重复的听觉反应在第二次植入激活两个月后被观察到。家长与治疗师的良好合作以及患者明确的发展目标使多学科团队能够利用儿童的智力能力并选择合适的沟通方法;然而,患者的听觉反应获得缓慢。内耳畸形由于解剖结构异常,最终听觉结果无法预测,因此,畸形耳蜗内神经分布不均。声音处理器的编程必须在每种情况下都是单独的,基于儿童的行为观察,如果可能的话,还有客观的测试结果。与耳蜗结构正常的患者相比,耳蜗畸形患者通常需要更高的刺激强度来获得声音感觉。
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引用次数: 0
Striking a balance between invasiveness and effectiveness of snoring treatment 在打鼾治疗的侵袭性和有效性之间取得平衡
Q4 Medicine Pub Date : 2022-12-31 DOI: 10.5604/01.3001.0016.2346
Pawel Scierski, Ścierski Wojciech, Iwona Sybis, Mateusz Frelich
Introduction: Snoring is a common form of breathing disturbances during sleep. Snoring is the most frequent an isolated symptom (called then primary snoring) but sometimes it is one of OSA or UARS symptoms. Primary snoring is not only a social but also a health problem. That is why we should diagnose and treat all the patients complaining of snoring. For many years, methods have been sought that would, on the one hand, ensure adequate effectiveness and, on the other hand, minimize the invasiveness of therapy.Aim: The aim of this study is to review the methods of snoring treatment paying attention to its invasiveness and effectiveness. Material and methods: The scientific publications on the Pubmed between 2005 and 2022 were reviewed using the key words.Results: A large variety of surgical procedures offered to patients who snore is an evidence to the lack of an optimal method of treatment. Methods of therapy are still being sought, which, on the one hand, would give a chance for a significant reduction of snoring and maintain this result for a longer period of time, and on the other hand, would be characterized by low invasiveness. One of the techniques that is characterized by low invasiveness and, at the same time, high efficiency in a selected group of patients snoring with the soft palate hypertrophy is the Er:YAG laser treatment.
引言:打鼾是睡眠中呼吸障碍的一种常见形式。打鼾是最常见的孤立症状(当时称为原发性打鼾),但有时它是OSA或UARS症状之一。原发性打鼾不仅是一个社会问题,也是一个健康问题。这就是为什么我们应该诊断和治疗所有抱怨打鼾的患者。多年来,人们一直在寻找方法,一方面确保足够的有效性,另一方面将治疗的侵入性降至最低。目的:本研究旨在综述打鼾的治疗方法,注意其侵入性和有效性。材料和方法:使用关键词对Pubmed上2005年至2022年的科学出版物进行了综述。结果:为打鼾患者提供的各种手术程序证明了缺乏最佳的治疗方法。治疗方法仍在寻求中,一方面,这些方法将有机会显著减少打鼾,并在更长的时间内保持这种结果,另一方面,其特点是侵袭性低。Er:YAG激光治疗是一种技术,其特点是在选定的一组打鼾伴软腭肥大的患者中具有低侵袭性和高效率。
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引用次数: 0
The role of metalloproteinases in the pathogenesis of Obstructive Sleep Apnea Syndrome 金属蛋白酶在阻塞性睡眠呼吸暂停综合征发病机制中的作用
Q4 Medicine Pub Date : 2022-12-31 DOI: 10.5604/01.3001.0016.2345
Nataliya Vasilenok, N. Olszewska, E. Olszewska
Obstructive Sleep Apnea Syndrome (OSAS) is a common sleep-related breathing disorder. Untreated OSAS leads to significant health consequences, disturbed functioning in society, decreased efficiency in a workplace and increased risk of accidents at work and while driving. The main patomechanisms of OSAS development are hypoxia, oxidative stress and inflammatory process. Intermittent hypoxia in OSAS patients is associated with subsequent episodes of reoxygenation with simultaneous increase of reactive oxygen species and reactive nitrogen species that stimulate secretion of extracellular metalloproteinases (MMPs). These compounds belong to a group of endogenous proteolytic enzymes produced by structural cells of extracellular matrix (ECM) and by cells of inflammatory response as well. ECMs are made of collagen proteins and glycoproteins. They form a scaffold for tissues of the soft palate. MMPs break down collagen molecules, which results in flaccidity of tissues, including tissues of the soft palate. The results of scientific studies have shown that expression, secretion, and activeness of MMPs increase during hypoxia. Thus metalloproteinases may be involved in the process of upper airway tissue damage during the intermittent hypoxia in OSAS.
阻塞性睡眠呼吸暂停综合征(OSAS)是一种常见的与睡眠有关的呼吸障碍。未经治疗的OSAS会导致严重的健康后果,扰乱社会功能,降低工作场所的效率,增加工作和驾驶时发生事故的风险。缺氧、氧化应激和炎症过程是OSAS发生的主要病理机制。OSAS患者的间歇性缺氧与随后的再氧发作相关,同时增加活性氧和活性氮,刺激细胞外金属蛋白酶(MMPs)的分泌。这些化合物属于一组内源性蛋白水解酶,由细胞外基质结构细胞和炎症反应细胞产生。ecm由胶原蛋白和糖蛋白组成。它们形成软腭组织的支架。MMPs会分解胶原蛋白分子,导致组织松弛,包括软腭组织。科学研究结果表明,缺氧时MMPs的表达、分泌和活性增加。因此,金属蛋白酶可能参与了OSAS患者间歇性缺氧时上气道组织损伤的过程。
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引用次数: 0
Dermatofibrosarcoma protuberans of left temporal area with mass effect causing stenosis of EAM in 66-year-old patient - case report. 66岁左颞区隆起性皮肤纤维肉瘤伴肿块效应致EAM狭窄1例报告。
Q4 Medicine Pub Date : 2022-12-15 DOI: 10.5604/01.3001.0016.1565
Anna Bąk, W. Smółka, J. Markowski
ABSTRACT INTRODUCTION: Dermatofibrosarcoma protuberans (DFSP) is a locally aggressive cutaneous sarcoma with a low metastasis potential, but a high local recurrence rate. It was first described in 1890 [1]. DFSP grows slowly and may take various forms in clinical trials - it presents both as a firm plaque, subcutaneous fat atrophy and a single or polycyclic tumor. Immunohistochemically DFSP, stains positive for CD34. The gold standard for DFSP treatment is a complete surgical excision with a margin of healthy tissue. Adjuvant therapy includes both radiotherapy and imatinib therapy. CASE REPORT: In June 2022, a 66-year-old patient with a tumor of left temporal area located behind the earlobe was admitted to the medical ward. The skin above the lesion remained unchanged. The imaging examination performed before the procedure showed a well-defined lesion and the results of the FNA biopsy np. BC-73765 were as follows: “numerous neoplastic cells, partially fusiform with atypical features, cytological picture does not allow to determine the malignancy of the tumor”. After performing the necessary examination, the patient underwent surgery. Histopathological biopsy report of the specimen came out as DFSP. Therefore, the patient was referred for adjuvant radiotherapy by the decision of the Medical Council.CONCLUSIONS: Due to high risk of recurrence and incidence of unclear margins after surgical excision, adjuvant radiotherapy is often used in the treatment of DFSP as it reduces the recurrence rate. KEY WORDS: DFSP, radiotherapy, Mohs micrographic surgery, surgical treatment.
摘要简介:皮肤纤维肉瘤隆突(DFSP)是一种局部侵袭性皮肤肉瘤,转移潜力低,但局部复发率高。它是在1890年首次被描述的。DFSP生长缓慢,在临床试验中可能表现为多种形式——它既表现为坚硬的斑块、皮下脂肪萎缩,也表现为单环状或多环状肿瘤。免疫组织化学DFSP染色CD34阳性。DFSP治疗的金标准是完全手术切除并保留健康组织。辅助治疗包括放疗和伊马替尼治疗。病例报告:2022年6月,一名66岁的患者因左侧颞区位于耳垂后的肿瘤住进内科病房。病灶上方的皮肤保持不变。术前影像学检查显示病灶清晰,FNA活检结果为np。BC-73765的结论如下:“肿瘤细胞众多,部分梭形,不典型特征,细胞学图像不能确定肿瘤的恶性”。在做了必要的检查后,病人接受了手术。标本的组织病理活检报告为DFSP。因此,根据医务委员会的决定,病人被转介接受辅助放射治疗。结论:由于手术切除后DFSP复发率高、边界不清,辅助放疗可降低复发率,故常用于DFSP的治疗。关键词:DFSP,放疗,莫氏显微摄影手术,手术治疗。
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Polish Otorhinolaryngology Review
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