Z. Gholami, M. Dianati, Mahboobeh Maghami, M. Afazel, Ismail Azizi-fini
This study aimed to examine the effect of Zataria multiflora Boiss. mouthwash on the microbial load of the oral cavity in patients under mechanical ventilation. This randomized controlled trial was conducted in 2019 on patients under mechanical ventilation. Sampling was performed using the consecutive method. Using a block randomization method, 90 patients were allocated to three equal groups of 30 to receive mouth care using chlorhexidine, Z. multiflora, or normal saline. Mouthwash was used three times a day for a week. Eight hours before and after the intervention, sterile samples of saliva were collected and cultured in the laboratory. Chi-square, Fisher’s exact test, paired t and McNemar’s tests, and analysis of variance were used to analyze the data. After the interventions, a significant difference in the microbial load was found between the three groups (P < 0.021). The Tukey post hoc test showed a significant difference between the group treated with Z. multiflora and those who received chlorhexidine (P value = 0.016). The frequency of patients with positive cultures was lower in the group treated with Z. multiflora and the differences were statistically significant in terms of Acinetobacter (P = 0.01) and Klebsiella pneumonia (P = 0.02). Z. multiflora mouthwash was effective in decreasing the microbial load of the oral cavity. This mouthwash can be used to reduce the microbial load of the oral cavity in patients under mechanical ventilation and reduce the risk of ventilator-associated pneumonia.
{"title":"The Effect of Zataria multiflora Boiss. Mouthwash on the Oral Microbial Load in Patients under Mechanical Ventilation: A Randomized Controlled Trial","authors":"Z. Gholami, M. Dianati, Mahboobeh Maghami, M. Afazel, Ismail Azizi-fini","doi":"10.18502/tim.v7i2.9919","DOIUrl":"https://doi.org/10.18502/tim.v7i2.9919","url":null,"abstract":"This study aimed to examine the effect of Zataria multiflora Boiss. mouthwash on the microbial load of the oral cavity in patients under mechanical ventilation. This randomized controlled trial was conducted in 2019 on patients under mechanical ventilation. Sampling was performed using the consecutive method. Using a block randomization method, 90 patients were allocated to three equal groups of 30 to receive mouth care using chlorhexidine, Z. multiflora, or normal saline. Mouthwash was used three times a day for a week. Eight hours before and after the intervention, sterile samples of saliva were collected and cultured in the laboratory. Chi-square, Fisher’s exact test, paired t and McNemar’s tests, and analysis of variance were used to analyze the data. After the interventions, a significant difference in the microbial load was found between the three groups (P < 0.021). The Tukey post hoc test showed a significant difference between the group treated with Z. multiflora and those who received chlorhexidine (P value = 0.016). The frequency of patients with positive cultures was lower in the group treated with Z. multiflora and the differences were statistically significant in terms of Acinetobacter (P = 0.01) and Klebsiella pneumonia (P = 0.02). Z. multiflora mouthwash was effective in decreasing the microbial load of the oral cavity. This mouthwash can be used to reduce the microbial load of the oral cavity in patients under mechanical ventilation and reduce the risk of ventilator-associated pneumonia.","PeriodicalId":52659,"journal":{"name":"Traditional and Integrative Medicine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48079283","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Maryam Naseri, Hanieh Delfani, S. Mirzaeei, G. Bahrami, M. Farzaei, Pardis Mohammadi Pour
Dying Various therapeutic activities of Pistacia atlantica var. mutica such as hypoglycemic, antioxidant and anti-inflam matory activity were shown by several studies. Regarding these therapeutic activities, and due to advantages of nanoparticles for drug delivery systems, the anti-colitic effects of P. atlantica var. mutica oleoresin nanoparticles were studied in acetic acid-induced ulcerative colitis in rats. Nanoparticles were synthesized by using ethanol and acetone as solvent. Nano precipitation method was also used for nanoparticles synthesis. P. atlantica oleoresin was orally administered to acetic acid-induced colitis rats at the doses of 50, 100 and 200 mg/kg. Then rats were killed and their colons were dissected away for histopathological and macroscopic tests. Statistical results showed homogeneity and uniformity in size and size distribution of fabricated nanoparticles. Proposed models for size and size distribution of nanoparticles were also adequate (P value < 0.05). All doses of nanoparticles of P. atlantica oleoresin significantly reduced macroscopic damage score. The microscopic study also showed anti-colitic activities of P. atlantica oleoresin nanoparticles. Administration of 200 mg/kg of fabricated nanoparticles showed better anti-inflammatory and healing effects compared to other doses. Our results showed that nanoparticles of P. atlantica var. mutica oleoresin might be an effective agent to treat ulcerative colitis disease, due to the therapeutic activities of the plant and desirable properties of fabricated nanoparticles. Therefore, nanoparticles of P. atlantica var. mutica oleoresin might provide an alternative drug for colonic inflammation.
{"title":"Protective Effect of Nanoparticles of Oleoresin of Pistacia atlantica var. mutica Against Acetic Acid-Induced Ulcerative Colitis in Rats","authors":"Maryam Naseri, Hanieh Delfani, S. Mirzaeei, G. Bahrami, M. Farzaei, Pardis Mohammadi Pour","doi":"10.18502/tim.v7i2.9915","DOIUrl":"https://doi.org/10.18502/tim.v7i2.9915","url":null,"abstract":"Dying Various therapeutic activities of Pistacia atlantica var. mutica such as hypoglycemic, antioxidant and anti-inflam matory activity were shown by several studies. Regarding these therapeutic activities, and due to advantages of nanoparticles for drug delivery systems, the anti-colitic effects of P. atlantica var. mutica oleoresin nanoparticles were studied in acetic acid-induced ulcerative colitis in rats. Nanoparticles were synthesized by using ethanol and acetone as solvent. Nano precipitation method was also used for nanoparticles synthesis. P. atlantica oleoresin was orally administered to acetic acid-induced colitis rats at the doses of 50, 100 and 200 mg/kg. Then rats were killed and their colons were dissected away for histopathological and macroscopic tests. Statistical results showed homogeneity and uniformity in size and size distribution of fabricated nanoparticles. Proposed models for size and size distribution of nanoparticles were also adequate (P value < 0.05). All doses of nanoparticles of P. atlantica oleoresin significantly reduced macroscopic damage score. The microscopic study also showed anti-colitic activities of P. atlantica oleoresin nanoparticles. Administration of 200 mg/kg of fabricated nanoparticles showed better anti-inflammatory and healing effects compared to other doses. Our results showed that nanoparticles of P. atlantica var. mutica oleoresin might be an effective agent to treat ulcerative colitis disease, due to the therapeutic activities of the plant and desirable properties of fabricated nanoparticles. Therefore, nanoparticles of P. atlantica var. mutica oleoresin might provide an alternative drug for colonic inflammation.","PeriodicalId":52659,"journal":{"name":"Traditional and Integrative Medicine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45524037","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
S. Vagharseyyedin, Mojgan Kardan, H. Rahimi, H. B. Bahrami Taghanaki, N. Azdaki
Back pain is a common complaint seen in patients after coronary angiography. This study investigated the efficacy of ear acupressure for reduction of back pain in patients after coronary angiography. In this trial, 120 patients recruited from a post-angiography ward were allocated to an ear acupressure or a control group. Pain assessment in intervention group was performed immediately after participants entered post- coronary angiography ward (T0), twenty minutes after entering the ward (T1), and two, four, and six hours after the intervention (T2–T4). Pain in control group was assessed at the times similar to intervention group. Data were analyzed using the SPSS software (v. 19) by Chi-square, Fisher’s exact, independent t tests, Friedman test, Wilcoxon signed-rank, and Mann-Whitney U test. Final data analysis was done on the data gathered from 58 participants in the control group and 59 in the ear acupressure group. The pain intensity at T1–T4 for patients in the control group was significantly higher than T0 (P < 0.001), while patients in the ear acupressure group reported that pain intensity at T2–T4 was significantly higher than T0 for them (P < 0.001). Only at T1 and T2, pain intensity in the ear acupressure group was significantly less compared to the control group (P < 0.05). Ear acupressure in this study was effective to some extent in reducing back pain after coronary angiography. Future studies can be designed to examine the effects of ear acupressure using different ear acupressure points on the back pain after coronary angiography.
{"title":"The Effects of Ear Acupressure on Back Pain after Coronary Angiography: A Randomized Controlled Trial","authors":"S. Vagharseyyedin, Mojgan Kardan, H. Rahimi, H. B. Bahrami Taghanaki, N. Azdaki","doi":"10.18502/tim.v7i2.9917","DOIUrl":"https://doi.org/10.18502/tim.v7i2.9917","url":null,"abstract":"Back pain is a common complaint seen in patients after coronary angiography. This study investigated the efficacy of ear acupressure for reduction of back pain in patients after coronary angiography. In this trial, 120 patients recruited from a post-angiography ward were allocated to an ear acupressure or a control group. Pain assessment in intervention group was performed immediately after participants entered post- coronary angiography ward (T0), twenty minutes after entering the ward (T1), and two, four, and six hours after the intervention (T2–T4). Pain in control group was assessed at the times similar to intervention group. Data were analyzed using the SPSS software (v. 19) by Chi-square, Fisher’s exact, independent t tests, Friedman test, Wilcoxon signed-rank, and Mann-Whitney U test. Final data analysis was done on the data gathered from 58 participants in the control group and 59 in the ear acupressure group. The pain intensity at T1–T4 for patients in the control group was significantly higher than T0 (P < 0.001), while patients in the ear acupressure group reported that pain intensity at T2–T4 was significantly higher than T0 for them (P < 0.001). Only at T1 and T2, pain intensity in the ear acupressure group was significantly less compared to the control group (P < 0.05). Ear acupressure in this study was effective to some extent in reducing back pain after coronary angiography. Future studies can be designed to examine the effects of ear acupressure using different ear acupressure points on the back pain after coronary angiography.","PeriodicalId":52659,"journal":{"name":"Traditional and Integrative Medicine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47245299","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. -, M. Azhar, Sofia Naushin, Mohd Urooj, Gulam Mohammed Husain
The ultra-fine powder of Sang-e-Surma (Surma Stone), also known as Kohl, is used for various eye ailments either alone or in combination with other herbal or mineral ingredients. The earliest use of Surma is reported in Egypt about 3100 BC. Data from a number of studies conducted on Sang-e-Surma using modern analytical techniques have cleared the uncertainty that Surma stone is mainly composed of lead sulphide. Surma is reported to be used for impaired eye-sight, ophthalmia, cataract, itching, redness, irritation, watering of eyes, shedding of eyelashes and in the initial stage of cataract. The use of lead based Surma is discouraged owing to reports of lead toxicity though the sun glare protection and antimicrobial effects of Surma have been established. Reports on lead toxicity by the application of Surma in eyes are conflicting. Appropriately planned studies are warranted to elaborate the toxic effects of lead based Surma/kohl in terms of detoxification of Sang-e-Surma, preclinical toxicity and clinical trial.
{"title":"Overview of Sang-e-Surma (Antimony Sulphide or Lead Sulphide): A Mineral Origin Unani Drug","authors":"M. -, M. Azhar, Sofia Naushin, Mohd Urooj, Gulam Mohammed Husain","doi":"10.18502/tim.v7i1.9069","DOIUrl":"https://doi.org/10.18502/tim.v7i1.9069","url":null,"abstract":"The ultra-fine powder of Sang-e-Surma (Surma Stone), also known as Kohl, is used for various eye ailments either alone or in combination with other herbal or mineral ingredients. The earliest use of Surma is reported in Egypt about 3100 BC. Data from a number of studies conducted on Sang-e-Surma using modern analytical techniques have cleared the uncertainty that Surma stone is mainly composed of lead sulphide. Surma is reported to be used for impaired eye-sight, ophthalmia, cataract, itching, redness, irritation, watering of eyes, shedding of eyelashes and in the initial stage of cataract. The use of lead based Surma is discouraged owing to reports of lead toxicity though the sun glare protection and antimicrobial effects of Surma have been established. Reports on lead toxicity by the application of Surma in eyes are conflicting. Appropriately planned studies are warranted to elaborate the toxic effects of lead based Surma/kohl in terms of detoxification of Sang-e-Surma, preclinical toxicity and clinical trial.","PeriodicalId":52659,"journal":{"name":"Traditional and Integrative Medicine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48793499","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Quadri Olaide Nurudeen, S. S. Salimon, M. Falana, M. Yakubu, M. A. Akanji
Over generations, several indigenous knowledge on the use of medicinal plants have been lost due to a lack of interest of the upcoming generation and reluctancy of the older generations to pass on their knowledge. This survey was set about to preserve and share the knowledge of the Ilorin Emirate Clan in the management of female sexual dysfunction and infertility (FSDI). The survey was conducted across three major markets (Shao, Jimba-Oja and Oke-Oyi) and ethnobotanical data on medicinal plants, mode of preparation, route of administration and demographic information were collected from volunteers using a semi-structured questionnaire, oral or virtual interviews. A total of 47 plant species belonging to 28 families were identified from 85 willing respondents. Phyllanthus amarus Schumach. & Thonn. was the most frequently cited plant with a citation frequency of 31.76% and a fidelity level of 57.75% whereas Xylopia aethiopica (Dunal) A.Rich. was the least cited plant with a citation frequency of 1.18% and a fidelity level of 1.12%. The highest informant consensus factor computed for Shao market, Jimba-Oja and Oke-Oyi were 0.93, 0.57 and 0.84 for P. amarus, Sarcocephalus latifolius (Sm.) E.A.Bruce and Cassia fistula L., respectively. This study provides a comprehensive insight into the medicinal plants in our society that are of importance in the management of female sexual dysfunction and infertility. The data collected would promote the conservation of invaluable indigenous knowledge and highlight a broad selection of medicinal plants that could be subjected to further pharmacological and clinical investigation for their potential role in the treatment of FSDI.
几代人以来，由于下一代缺乏兴趣和老一辈不愿传承他们的知识，一些关于药用植物使用的土著知识已经丢失。这项调查旨在保存和分享伊洛林酋长国氏族在管理女性性功能障碍和不孕症(FSDI)方面的知识。该调查在三个主要市场(邵、金巴-欧加和奥克-欧依)进行，并通过半结构化问卷、口头或虚拟访谈从志愿者那里收集了药用植物、制备方式、给药途径和人口统计信息的民族植物学数据。在85名自愿调查对象中，共鉴定出28科47种植物。Phyllanthus amarus Schumach。& Thonn。被引频次最高的植物是埃塞俄比亚木(Xylopia aethiopica (Dunal) a . rich;被引频次为1.18%，保真度为1.12%，是被引最少的植物。邵市场、金巴-奥加和奥克-奥伊的最高信息一致因子分别为0.93、0.57和0.84。e。a。bruce和决明子瘘管L。本研究提供了一个全面的认识，在我们的社会药用植物的重要性，在女性性功能障碍和不孕症的管理。收集到的数据将促进宝贵的本土知识的保护，并突出了广泛的药用植物选择，这些植物可以进行进一步的药理学和临床研究，以确定它们在治疗FSDI中的潜在作用。
{"title":"Ethnopharmacological Survey of Plants Used for the Treatment of Female Sexual Dysfunction and Infertility in Ilorin, Nigeria","authors":"Quadri Olaide Nurudeen, S. S. Salimon, M. Falana, M. Yakubu, M. A. Akanji","doi":"10.18502/tim.v7i1.9068","DOIUrl":"https://doi.org/10.18502/tim.v7i1.9068","url":null,"abstract":"Over generations, several indigenous knowledge on the use of medicinal plants have been lost due to a lack of interest of the upcoming generation and reluctancy of the older generations to pass on their knowledge. This survey was set about to preserve and share the knowledge of the Ilorin Emirate Clan in the management of female sexual dysfunction and infertility (FSDI). The survey was conducted across three major markets (Shao, Jimba-Oja and Oke-Oyi) and ethnobotanical data on medicinal plants, mode of preparation, route of administration and demographic information were collected from volunteers using a semi-structured questionnaire, oral or virtual interviews. A total of 47 plant species belonging to 28 families were identified from 85 willing respondents. Phyllanthus amarus Schumach. & Thonn. was the most frequently cited plant with a citation frequency of 31.76% and a fidelity level of 57.75% whereas Xylopia aethiopica (Dunal) A.Rich. was the least cited plant with a citation frequency of 1.18% and a fidelity level of 1.12%. The highest informant consensus factor computed for Shao market, Jimba-Oja and Oke-Oyi were 0.93, 0.57 and 0.84 for P. amarus, Sarcocephalus latifolius (Sm.) E.A.Bruce and Cassia fistula L., respectively. This study provides a comprehensive insight into the medicinal plants in our society that are of importance in the management of female sexual dysfunction and infertility. The data collected would promote the conservation of invaluable indigenous knowledge and highlight a broad selection of medicinal plants that could be subjected to further pharmacological and clinical investigation for their potential role in the treatment of FSDI.","PeriodicalId":52659,"journal":{"name":"Traditional and Integrative Medicine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46492146","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Hoorieh Mohammadi kenari, Gholamreza Kordafshari, M. Moghimi
Cupping has a long history in Iran which is one of the most widely used methods in prevention and treatment of diseases in Persian medicine. However, it still has many opponents in the Iranian conventional medical community. So, this systematic review study was conducted to survey the scientific and authoritative articles related to wet and dry cupping that have been done in Iran and the diseases for which Iranian researchers have suggested cupping. In general, the effect of wet and dry cupping on various kinds of pain (e.g. headache, musculoskeletal pain, postpartum pain, etc.), as well as the effect of wet cupping on hematological and biochemical factors of blood were among the most common studies. Also, persistence of therapeutic effects of wet and dry cupping on various diseases was satisfactory. The results of this study showed that wet and dry cupping, even alone, are effective in the treatment of many diseases, and if the objections to the use of these two treatments are reduced, more extensive and high-quality researches in this regard will be done.
{"title":"The Effectiveness of Cupping in Iranian Researches: A Systematic Review of Animal and Human Studies","authors":"Hoorieh Mohammadi kenari, Gholamreza Kordafshari, M. Moghimi","doi":"10.18502/tim.v7i1.9070","DOIUrl":"https://doi.org/10.18502/tim.v7i1.9070","url":null,"abstract":"Cupping has a long history in Iran which is one of the most widely used methods in prevention and treatment of diseases in Persian medicine. However, it still has many opponents in the Iranian conventional medical community. So, this systematic review study was conducted to survey the scientific and authoritative articles related to wet and dry cupping that have been done in Iran and the diseases for which Iranian researchers have suggested cupping. In general, the effect of wet and dry cupping on various kinds of pain (e.g. headache, musculoskeletal pain, postpartum pain, etc.), as well as the effect of wet cupping on hematological and biochemical factors of blood were among the most common studies. Also, persistence of therapeutic effects of wet and dry cupping on various diseases was satisfactory. The results of this study showed that wet and dry cupping, even alone, are effective in the treatment of many diseases, and if the objections to the use of these two treatments are reduced, more extensive and high-quality researches in this regard will be done.","PeriodicalId":52659,"journal":{"name":"Traditional and Integrative Medicine","volume":"52 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41305538","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jushanda (decoction), often used in traditional medicine, has many drawbacks like disagreeable taste, bulky dose, cumbersome preparation, and short stability. Therefore, in the present study, jushanda nazla (JN) was modified and optimized into a sugar-based (SBS) and sugar-free (SFS) syrup dosage form and evaluated for various physicochemical parameters, microbial contaminations and antimicrobial activities. JN was concentrated and reduced to minimum quantity by heating and twelve batches of SBS and five batches of SFS were prepared for optimization. Out of these, the best batch of SBS and SFS were selected based on consistency and minimum bulk. The best batches were further evaluated for the physicochemical parameter, microbial and heavy metal contamination. The finished products were also evaluated for antimicrobial activity against selected microbes. SBS was optimized with 170 mL JN reduced to 50 mL, sugar 40% (w/v) and consistency of one wire. SFS was optimized with 170 mL JN reduced to 30 mL, and 96 mg of aspartame. Organoleptic characters, ash value, viscosity, specific gravity and pH of finished products were satisfactory. The concentration of total phenolic, flavonoid, tannin, alkaloid and glycyrrhizin and chlorogenic acid were comparative in JN, SBS and SFS. SBS and SFS passed the WHO guideline for microbial and heavy metal contamination. Finished products showed significant antimicrobial activity against Streptococcus pyogenes, Streptococcus pneumoniae, Haemophilus influenzae and Salmonella. Analytical data of SBS and SFS showed significant optimistic results hence, generated data can be used for future reference. However, developed formulations should be further evaluated for their stability, safety and clinical efficacy.
中药中常用的巨山大汤剂有味不好、用量大、配制繁琐、稳定性差等缺点。因此，在本研究中，jushanda nazla（JN）被改性和优化为基于糖（SBS）和无糖（SFS）的糖浆剂型，并评估了各种物理化学参数、微生物污染和抗菌活性。浓缩JN并通过加热将其减少到最小量，制备12批SBS和5批SFS进行优化。其中，根据一致性和最小体积选择了最佳批次的SBS和SFS。进一步评估了最佳批次的物理化学参数、微生物和重金属污染。还评估了成品对选定微生物的抗菌活性。SBS用170mL JN减少到50mL、糖40%（w/v）和一根丝线的稠度进行优化。SFS用170 mL JN减少到30 mL和96 mg阿斯巴甜进行优化。成品的感官性状、灰分、粘度、比重和pH值均令人满意。比较了JN、SBS和SFS中总酚、黄酮、单宁、生物碱、甘草甜素和绿原酸的浓度。SBS和SFS通过了世界卫生组织微生物和重金属污染指南。成品对化脓性链球菌、肺炎链球菌、流感嗜血杆菌和沙门氏菌具有显著的抗菌活性。SBS和SFS的分析数据显示出显著的乐观结果，因此生成的数据可供未来参考。然而，开发的制剂应进一步评估其稳定性、安全性和临床疗效。
{"title":"Formulation Development, Characterization and Antimicrobial Activity Evaluation of Sugar-Based and Sugar-Free Syrup Prepared with the Ingredients of Jushanda-Nazla","authors":"Syed Zubair Ali, Khaleequr Rahman, A. Sultana","doi":"10.18502/tim.v7i1.9067","DOIUrl":"https://doi.org/10.18502/tim.v7i1.9067","url":null,"abstract":"Jushanda (decoction), often used in traditional medicine, has many drawbacks like disagreeable taste, bulky dose, cumbersome preparation, and short stability. Therefore, in the present study, jushanda nazla (JN) was modified and optimized into a sugar-based (SBS) and sugar-free (SFS) syrup dosage form and evaluated for various physicochemical parameters, microbial contaminations and antimicrobial activities. JN was concentrated and reduced to minimum quantity by heating and twelve batches of SBS and five batches of SFS were prepared for optimization. Out of these, the best batch of SBS and SFS were selected based on consistency and minimum bulk. The best batches were further evaluated for the physicochemical parameter, microbial and heavy metal contamination. The finished products were also evaluated for antimicrobial activity against selected microbes. SBS was optimized with 170 mL JN reduced to 50 mL, sugar 40% (w/v) and consistency of one wire. SFS was optimized with 170 mL JN reduced to 30 mL, and 96 mg of aspartame. Organoleptic characters, ash value, viscosity, specific gravity and pH of finished products were satisfactory. The concentration of total phenolic, flavonoid, tannin, alkaloid and glycyrrhizin and chlorogenic acid were comparative in JN, SBS and SFS. SBS and SFS passed the WHO guideline for microbial and heavy metal contamination. Finished products showed significant antimicrobial activity against Streptococcus pyogenes, Streptococcus pneumoniae, Haemophilus influenzae and Salmonella. Analytical data of SBS and SFS showed significant optimistic results hence, generated data can be used for future reference. However, developed formulations should be further evaluated for their stability, safety and clinical efficacy.","PeriodicalId":52659,"journal":{"name":"Traditional and Integrative Medicine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46948605","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. Abdolahinia, M. Naseri, S. Tahmasbi, P. Adimi, M. Sadr, A. Velayati
Persian medicine introduces six essential principles to maintain health and improve the breathing of the patients with pulmonary diseases. Adherence to each of these principles plays an important role in having healthy lungs. The purpose of this study was to review the scientific evidence of the mentioned recommendations while discussing the Persian medicine recommendations. Accordingly, suggestions related to maintaining lung health were extracted from the main sources of Persian medicine. In addition, similar topics were searched in PubMed, Scopus, Google Scholar, Web of Science, and SID databases. Then, results were expressed separately in each aspect of the six essential principles. These recommendations which are the result of hundreds-of-years-experience of Iranian physicians could be useful; however, future experimental investigations are needed to approve their safety and efficacy along with the possible mechanisms of action.
波斯医学介绍了维持肺部疾病患者健康和改善呼吸的六项基本原则。坚持这些原则对拥有健康的肺部起着重要作用。本研究的目的是在讨论波斯医学建议的同时，审查上述建议的科学证据。因此，从波斯医学的主要来源中提取了与保持肺部健康有关的建议。此外，在PubMed、Scopus、Google Scholar、Web of Science和SID数据库中也搜索到了类似的主题。然后，在六个基本原则的每个方面分别表达结果。这些建议是伊朗医生数百年经验的结果，可能是有用的；然而，未来的实验研究还需要验证它们的安全性和有效性以及可能的作用机制。
{"title":"Ideal Lifestyle to Have Healthy Lungs: Persian Medicine Viewpoint","authors":"A. Abdolahinia, M. Naseri, S. Tahmasbi, P. Adimi, M. Sadr, A. Velayati","doi":"10.18502/tim.v7i1.9071","DOIUrl":"https://doi.org/10.18502/tim.v7i1.9071","url":null,"abstract":"Persian medicine introduces six essential principles to maintain health and improve the breathing of the patients with pulmonary diseases. Adherence to each of these principles plays an important role in having healthy lungs. The purpose of this study was to review the scientific evidence of the mentioned recommendations while discussing the Persian medicine recommendations. Accordingly, suggestions related to maintaining lung health were extracted from the main sources of Persian medicine. In addition, similar topics were searched in PubMed, Scopus, Google Scholar, Web of Science, and SID databases. Then, results were expressed separately in each aspect of the six essential principles. These recommendations which are the result of hundreds-of-years-experience of Iranian physicians could be useful; however, future experimental investigations are needed to approve their safety and efficacy along with the possible mechanisms of action.","PeriodicalId":52659,"journal":{"name":"Traditional and Integrative Medicine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47069029","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Corchorus olitorius L. is a medicinal herb with anti-inflammatory, laxative, and tonic properties, which is effective on the treatment of cancer and tumors. In this study, the extraction efficiency of supercritical fluid extraction (SFE) and ultrasound-assisted extraction (UAE) of C. olitorius as well as their antioxidant activities were investigated by 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radical. For this purpose, central composite block cube star and central composite design were employed to determine the optimal conditions. Thereafter, the qualification analysis of the effective ingredients of C. olitorius was done by LC-ESI-MS in negative mode. The results of LC-MS showed that C. olitorius includes phenolic and flavonoid compounds such as caffeic acid, p-coumaric acid, trans-ferulic acid, quercetin, naringenin, cirsiliol, cirsilineol, quercetrin, and naringin. Moreover, the SFE efficiency of extraction and IC50 value was obtained 4.25% and 1208.99 µg/mL, respectively. Also, the UAE efficiency of extraction and IC50 of antioxidant activity was obtained as 15.29% and 994.284 µg/mL, respectively. These results confirmed that the efficiencies of extraction and antioxidant activity of UAE were higher than that of SFE; however, the SFE is an environmentally friendly method and consumed less organic solvent.
{"title":"Comparison of Supercritical Fluid Extraction and Ultrasound-Assisted Extraction of Corchorus Olitorius L. and Evaluation of Their Antioxidant Properties and Identification of Compounds Using LC-ESI-MS","authors":"Hanieh Nasrollahi, M. Karimi, F. Raofie","doi":"10.18502/tim.v7i1.9065","DOIUrl":"https://doi.org/10.18502/tim.v7i1.9065","url":null,"abstract":"Corchorus olitorius L. is a medicinal herb with anti-inflammatory, laxative, and tonic properties, which is effective on the treatment of cancer and tumors. In this study, the extraction efficiency of supercritical fluid extraction (SFE) and ultrasound-assisted extraction (UAE) of C. olitorius as well as their antioxidant activities were investigated by 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radical. For this purpose, central composite block cube star and central composite design were employed to determine the optimal conditions. Thereafter, the qualification analysis of the effective ingredients of C. olitorius was done by LC-ESI-MS in negative mode. The results of LC-MS showed that C. olitorius includes phenolic and flavonoid compounds such as caffeic acid, p-coumaric acid, trans-ferulic acid, quercetin, naringenin, cirsiliol, cirsilineol, quercetrin, and naringin. Moreover, the SFE efficiency of extraction and IC50 value was obtained 4.25% and 1208.99 µg/mL, respectively. Also, the UAE efficiency of extraction and IC50 of antioxidant activity was obtained as 15.29% and 994.284 µg/mL, respectively. These results confirmed that the efficiencies of extraction and antioxidant activity of UAE were higher than that of SFE; however, the SFE is an environmentally friendly method and consumed less organic solvent.","PeriodicalId":52659,"journal":{"name":"Traditional and Integrative Medicine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43994205","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Masoud Sadeghi Dinani, J. Rezapour, S. Soleimanifard
Leishmaniasis is one of the infectious diseases in tropical countries that is seen as cutaneous, mucocutaneous and visceral forms. Due to the side effects, costs and effectiveness of anti-leishmaniasis drugs, many clinical trials have been conducted on the importance of plant-based substances against leishmaniasis. Therefore, the following study was performed to evaluate the therapeutic effects of Perovskia abrotanoides Kar. terpenoid fraction on cutaneous leishmaniasis in Balb/c mice. The ethanol: water (80:20) extract of the plant flowers was fractionated by Medium Pressure Liquid Chromatography using RP-18 column. The terpenoid-rich fraction was detected by TLC and HNMR analyses and evaluated for healing effects on cutaneous leishmaniasis in mice with concentrations of 0.8%, 1.6% and 3.2 µg/mL. The effect of that was evaluated using ANOVA statistical tests. The results indicate that terpenoid of P. abrotanoides in 3.2% concentration is effective in treating cutaneous leishmaniasis in mice and also increases the lifespan and decreases the parasite burden of infected mice. According to this result, it is suggested that the effectiveness of this extract on the treatment of cutaneous leishmaniasis to be evaluated as a clinical trial in humans.
{"title":"Treatment Role of Terpenoid Fraction of Perovskia abrotanoides Kar. on Zoonotic Cutaneous Leishmaniasis in Animal Model","authors":"Masoud Sadeghi Dinani, J. Rezapour, S. Soleimanifard","doi":"10.18502/tim.v7i1.9064","DOIUrl":"https://doi.org/10.18502/tim.v7i1.9064","url":null,"abstract":"Leishmaniasis is one of the infectious diseases in tropical countries that is seen as cutaneous, mucocutaneous and visceral forms. Due to the side effects, costs and effectiveness of anti-leishmaniasis drugs, many clinical trials have been conducted on the importance of plant-based substances against leishmaniasis. Therefore, the following study was performed to evaluate the therapeutic effects of Perovskia abrotanoides Kar. terpenoid fraction on cutaneous leishmaniasis in Balb/c mice. The ethanol: water (80:20) extract of the plant flowers was fractionated by Medium Pressure Liquid Chromatography using RP-18 column. The terpenoid-rich fraction was detected by TLC and HNMR analyses and evaluated for healing effects on cutaneous leishmaniasis in mice with concentrations of 0.8%, 1.6% and 3.2 µg/mL. The effect of that was evaluated using ANOVA statistical tests. The results indicate that terpenoid of P. abrotanoides in 3.2% concentration is effective in treating cutaneous leishmaniasis in mice and also increases the lifespan and decreases the parasite burden of infected mice. According to this result, it is suggested that the effectiveness of this extract on the treatment of cutaneous leishmaniasis to be evaluated as a clinical trial in humans.","PeriodicalId":52659,"journal":{"name":"Traditional and Integrative Medicine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41809498","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
京公网安备 11010802042870号
京ICP备2023020795号-1
扫码关注我们
求助内容：
应助结果提醒方式：