Saeed Ebrahimi Fana, Fathollah Ahmadpour, H. Rasouli, M. Maniati
Many Earthworm (EW) related effects have been introduced so far including, wound healing effects as well as anti-microbial, anti-inflammatory and anti-thrombosis effects. EW biomaterials could also be a therapeutic agent for various neuroinflammatory conditions. Besides, indigenous people traditionally have practiced the extraction of medicinal compounds from EW. Therefore, the present study aimed to investigate the EW capacities in nerve regeneration. An exhaustive literature search was performed using databases including PubMed, Scopus, Web of Science and Google. A total of 13 studies were included. All of them included an animal model or were cell culture studies between 2009 and 2018. The description of these findings is given in table 1. Despite the limited number of publications and their controversial results, EW can be regarded as a new promising option for nerve repair, given the several pieces of evidence confirming the effects of EW biomaterials on nerve injury and regeneration.
迄今为止，许多与蚯蚓相关的作用已被介绍，包括伤口愈合作用以及抗微生物、抗炎和抗血栓形成作用。EW生物材料也可以作为治疗各种神经炎症的药物。此外，土著居民传统上从EW中提取药用化合物。因此，本研究旨在探讨电刺激对神经再生的影响。利用PubMed、Scopus、Web of Science和b谷歌等数据库进行了详尽的文献检索。共纳入13项研究。所有这些研究都包括动物模型或2009年至2018年间的细胞培养研究。对这些发现的描述见表1。尽管出版物数量有限，结果也存在争议，但考虑到有几项证据证实EW生物材料对神经损伤和再生的影响，EW可以被视为神经修复的一种新的有希望的选择。
{"title":"Earthworm as a Peripheral Nerve Regeneration Biomaterial: A Comprehensive Review","authors":"Saeed Ebrahimi Fana, Fathollah Ahmadpour, H. Rasouli, M. Maniati","doi":"10.18502/tim.v8i1.12405","DOIUrl":"https://doi.org/10.18502/tim.v8i1.12405","url":null,"abstract":"Many Earthworm (EW) related effects have been introduced so far including, wound healing effects as well as anti-microbial, anti-inflammatory and anti-thrombosis effects. EW biomaterials could also be a therapeutic agent for various neuroinflammatory conditions. Besides, indigenous people traditionally have practiced the extraction of medicinal compounds from EW. Therefore, the present study aimed to investigate the EW capacities in nerve regeneration. An exhaustive literature search was performed using databases including PubMed, Scopus, Web of Science and Google. A total of 13 studies were included. All of them included an animal model or were cell culture studies between 2009 and 2018. The description of these findings is given in table 1. Despite the limited number of publications and their controversial results, EW can be regarded as a new promising option for nerve repair, given the several pieces of evidence confirming the effects of EW biomaterials on nerve injury and regeneration.","PeriodicalId":52659,"journal":{"name":"Traditional and Integrative Medicine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46088871","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Seyedeh Zahra Jokar, Tahereh Sadeghieh, M. Shakiba, M. Emtiazy, R. Sadeghmanesh, Monireh Seyed Hashemi, Z. Mousavi
Numerous researchers have examined the effect of diet on Attention Deficit Hyperactivity Disorder (ADHD). The purpose of this study is to compare the symptoms of ADHD in children fed horse milk versus conventionally fed cow's milk. Thirty patients aged 6 to 14 with ADHD were randomly selected and divided into two groups in this randomized double-blind crossover study. All patients completed a 45-day period of consuming 250 mL horse or cow milk, as well as continued Ritalin (1 mg/kg) treatment. The wash out period was considered one week. Symptoms are recorded using the Conners rating scale (CS). The CS of the parents decreased significantly (P value≤0.001) in the group that first received horse milk, but increased (P value=0.007) after consuming cow's milk. After consumption of horse milk, the parent's CS was significantly different from that of cow milk (P value= 0.001). Teachers' CS decreased significantly following horse milk consumption (P=0.001) and increased significantly following cow milk consumption (P=0.028) in this group. The average teacher's CS after cow milk differed significantly from that after horse milk (P value= 0.024). The CS of the parents did not change significantly (P value=0.913) in the group that first consumed cow's milk. However, it was significantly decreased (P value=0.004) after receiving horse milk. The CS of the teachers in this group did not change after the cow's milk (P value=0.282). However, following the administration of horse milk, the mean of CS decreased significantly (P=0.003). The average of the teacher's CS after consuming cow milk differed significantly from that of horse milk (P value= 0.010). In both groups, there was no significant difference in the mean of parents and teachers CS before and after the washout period (P>0.05). According to the study, horse milk consumption was significantly more effective than cow milk at lowering scores.
{"title":"Comparison of Horse and Cow Milk on the Symptoms of Attention Deficit Hyperactivity Disorder in Children: A Cross-Over Clinical Trial Study","authors":"Seyedeh Zahra Jokar, Tahereh Sadeghieh, M. Shakiba, M. Emtiazy, R. Sadeghmanesh, Monireh Seyed Hashemi, Z. Mousavi","doi":"10.18502/tim.v8i1.12403","DOIUrl":"https://doi.org/10.18502/tim.v8i1.12403","url":null,"abstract":"Numerous researchers have examined the effect of diet on Attention Deficit Hyperactivity Disorder (ADHD). The purpose of this study is to compare the symptoms of ADHD in children fed horse milk versus conventionally fed cow's milk. Thirty patients aged 6 to 14 with ADHD were randomly selected and divided into two groups in this randomized double-blind crossover study. All patients completed a 45-day period of consuming 250 mL horse or cow milk, as well as continued Ritalin (1 mg/kg) treatment. The wash out period was considered one week. Symptoms are recorded using the Conners rating scale (CS). The CS of the parents decreased significantly (P value≤0.001) in the group that first received horse milk, but increased (P value=0.007) after consuming cow's milk. After consumption of horse milk, the parent's CS was significantly different from that of cow milk (P value= 0.001). Teachers' CS decreased significantly following horse milk consumption (P=0.001) and increased significantly following cow milk consumption (P=0.028) in this group. The average teacher's CS after cow milk differed significantly from that after horse milk (P value= 0.024). The CS of the parents did not change significantly (P value=0.913) in the group that first consumed cow's milk. However, it was significantly decreased (P value=0.004) after receiving horse milk. The CS of the teachers in this group did not change after the cow's milk (P value=0.282). However, following the administration of horse milk, the mean of CS decreased significantly (P=0.003). The average of the teacher's CS after consuming cow milk differed significantly from that of horse milk (P value= 0.010). In both groups, there was no significant difference in the mean of parents and teachers CS before and after the washout period (P>0.05). According to the study, horse milk consumption was significantly more effective than cow milk at lowering scores.","PeriodicalId":52659,"journal":{"name":"Traditional and Integrative Medicine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48599005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Krishna Purnawan Candra, Sulika, Maulida Rachmawati, A. Rahmadi, M. Rohmah, I. M. Ramdan, Yuliani
Passiflora foetida L. is an endemic herb species located in Kalimantan and is typically administered among the local population to maintain cardiovascular health. Previous studies examining its effectiveness remain limited. This study aimed to examine the effects of the P. foetida L. leaves decoction on adult blood pressure and its correlation with the demographics of hypertensive patients. A quasi-experiment was conducted by assigning the passion leaves decoction to 26 people randomly divided into two groups (13 individuals each) in two stages. The decoction was prepared by boiling 10 fresh cut leaves (6-7 g) in 400 mL water and letting half of the water volume evaporate. The decoction was freshly prepared daily for each respondent. The first group was administered the decoction at the initial stages of the study; while the second group was administered placebo. The treatment dose of 100 mL was administered twice (at 9 AM and 5 PM) for a period of seven days. The second stage was carried out three weeks following completion of the initial stage and placebo and decoction were administered to the first and second groups, respectively. Blood pressure data were analyzed using paired t-tests. The correlation between blood pressure and the demographics of hypertensive patients was analyzed using Kendall's Tau-b and Spearman's test. We demonstrated that the passion leaves decoction significantly reduced blood pressure in hypertensive patients (p<0.01). The decoction was shown to improve the blood pressure profile of hypertensive patients, reducing the number of hypertensive patients with second-degree hypertension prevalence from 57.69% to 7.69% and 30.77% to 7.69% for systolic and diastolic blood pressure, respectively. Our findings also demonstrated that the decoction eliminated the correlation between age, occupation, body weight status, and blood pressure. The P. foetida leaves decoction can potentially be developed as an herbal tea to maintain blood pressure among hypertensive patients across the globe.
{"title":"The Effect of Passiflora foetida L. Leaves Decoction on Blood Pressure Profile and Its Correlation with the Demographics of Hypertensive Patients","authors":"Krishna Purnawan Candra, Sulika, Maulida Rachmawati, A. Rahmadi, M. Rohmah, I. M. Ramdan, Yuliani","doi":"10.18502/tim.v8i1.12401","DOIUrl":"https://doi.org/10.18502/tim.v8i1.12401","url":null,"abstract":"Passiflora foetida L. is an endemic herb species located in Kalimantan and is typically administered among the local population to maintain cardiovascular health. Previous studies examining its effectiveness remain limited. This study aimed to examine the effects of the P. foetida L. leaves decoction on adult blood pressure and its correlation with the demographics of hypertensive patients. A quasi-experiment was conducted by assigning the passion leaves decoction to 26 people randomly divided into two groups (13 individuals each) in two stages. The decoction was prepared by boiling 10 fresh cut leaves (6-7 g) in 400 mL water and letting half of the water volume evaporate. The decoction was freshly prepared daily for each respondent. The first group was administered the decoction at the initial stages of the study; while the second group was administered placebo. The treatment dose of 100 mL was administered twice (at 9 AM and 5 PM) for a period of seven days. The second stage was carried out three weeks following completion of the initial stage and placebo and decoction were administered to the first and second groups, respectively. Blood pressure data were analyzed using paired t-tests. The correlation between blood pressure and the demographics of hypertensive patients was analyzed using Kendall's Tau-b and Spearman's test. We demonstrated that the passion leaves decoction significantly reduced blood pressure in hypertensive patients (p<0.01). The decoction was shown to improve the blood pressure profile of hypertensive patients, reducing the number of hypertensive patients with second-degree hypertension prevalence from 57.69% to 7.69% and 30.77% to 7.69% for systolic and diastolic blood pressure, respectively. Our findings also demonstrated that the decoction eliminated the correlation between age, occupation, body weight status, and blood pressure. The P. foetida leaves decoction can potentially be developed as an herbal tea to maintain blood pressure among hypertensive patients across the globe.","PeriodicalId":52659,"journal":{"name":"Traditional and Integrative Medicine","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41566264","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Masoud Moslemifard Khaledi, Hamed Mehdinezhad Gorji, N. Gorji, Reza Ghadimi, Seyyed Ali Mozaffarpur, H. Shirafkan
This study aimed to evaluate the effectiveness of a Persian Medicine-based dietary protocol (PM diet) in patients infected with COVID-19. A randomized clinical trial was performed from July 2020 to January 2021 in Tehran, Iran. Eighty patients admitted due to pulmonary dysfunction caused by COVID-19 were randomly allocated into two groups: the PM diet or the common hospital (CH) diet. Eight beds in 2 rooms were considered for each group. Patients were randomly hospitalized in these rooms and received these diets up to discharge or death.. Oxygen saturation level and duration of hospitalization, the rate of mortality, duration of fever, and duration of cough were considered as the primary and secondary outcomes, respectively. Oxygen saturation and fever duration were not different between groups (P value= 0.08, 0.312, respectively). But the duration of hospitalization and the duration of cough in the PM diet group were significantly shorter than in the CH diet (P value= 0.002, 0.009, and HR=2.02, 1.86 respectively). The mortality rate was significantly lower in the PM diet group than in the CH diet group (Odds ratio: 0.12, P value=0.026). PM diet caused a lower mortality rate, shorter hospital stay, and better improvement in cough, but did not have a significant effect on O2 saturation and fever.
{"title":"The Efficacy of a Persian Medicine-Based Dietary Protocol on Hospitalized COVID-19 Patients: A Randomized Controlled Trial","authors":"Masoud Moslemifard Khaledi, Hamed Mehdinezhad Gorji, N. Gorji, Reza Ghadimi, Seyyed Ali Mozaffarpur, H. Shirafkan","doi":"10.18502/tim.v8i1.12397","DOIUrl":"https://doi.org/10.18502/tim.v8i1.12397","url":null,"abstract":"This study aimed to evaluate the effectiveness of a Persian Medicine-based dietary protocol (PM diet) in patients infected with COVID-19. A randomized clinical trial was performed from July 2020 to January 2021 in Tehran, Iran. Eighty patients admitted due to pulmonary dysfunction caused by COVID-19 were randomly allocated into two groups: the PM diet or the common hospital (CH) diet. Eight beds in 2 rooms were considered for each group. Patients were randomly hospitalized in these rooms and received these diets up to discharge or death.. Oxygen saturation level and duration of hospitalization, the rate of mortality, duration of fever, and duration of cough were considered as the primary and secondary outcomes, respectively. Oxygen saturation and fever duration were not different between groups (P value= 0.08, 0.312, respectively). But the duration of hospitalization and the duration of cough in the PM diet group were significantly shorter than in the CH diet (P value= 0.002, 0.009, and HR=2.02, 1.86 respectively). The mortality rate was significantly lower in the PM diet group than in the CH diet group (Odds ratio: 0.12, P value=0.026). PM diet caused a lower mortality rate, shorter hospital stay, and better improvement in cough, but did not have a significant effect on O2 saturation and fever.","PeriodicalId":52659,"journal":{"name":"Traditional and Integrative Medicine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46623159","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Fatima El Kamari, D. Ousaaid, Hassan Laaroussi, Meryem Bakour, Asmae El Ghouizi, Y. E. Atki, B. Lyoussi, Abdelfattah Abdellaoui
Cymbopogon nardus (L.) Rendle is one of the medicinal plants widely used in folk medicine to cure certain diseases. The current work aims to assess the diuretic potential of C. nardus using animal models. Urine electrolytes (sodium and potassium), serum electrolytes (sodium, potassium, and chloride), blood urea, creatinine, creatinine clearance, osmolar clearance, urinary osmolarity, and urine flow were determined. To assess the diuretic effect of the studied plant, four groups of rats were used (n = 6). The control group received 10 mL of water, the second and third groups received two doses of the plant (100 and 150 mg/kg bw), and the last group received furosemide (10 mg/kg bw), the experiment sustained for seven days. Urine flow and electrolytes levels were studied. The single dose of C. nardus extract significantly increased urine flow after oral administration. In addition, daily administration of both doses of C. nardus significantly elevated urine excretion, opposite to the first group. C. nardus enhanced the urine elimination of sodium and potassium. Importantly, both doses have no effect on serum potassium level. Creatinine clearance was significantly elevated in a dose-dependent manner. This information will be considered as a keystone for further studies forward in applying new process to isolate active compounds of C. nardus responsible for its biological properties.
{"title":"Diuretic Effect of the Aqueous Extract of Cymbopogon nardus (L.) Rendle Compared with Furosemide in Wistar Rats","authors":"Fatima El Kamari, D. Ousaaid, Hassan Laaroussi, Meryem Bakour, Asmae El Ghouizi, Y. E. Atki, B. Lyoussi, Abdelfattah Abdellaoui","doi":"10.18502/tim.v8i1.12400","DOIUrl":"https://doi.org/10.18502/tim.v8i1.12400","url":null,"abstract":"Cymbopogon nardus (L.) Rendle is one of the medicinal plants widely used in folk medicine to cure certain diseases. The current work aims to assess the diuretic potential of C. nardus using animal models. Urine electrolytes (sodium and potassium), serum electrolytes (sodium, potassium, and chloride), blood urea, creatinine, creatinine clearance, osmolar clearance, urinary osmolarity, and urine flow were determined. To assess the diuretic effect of the studied plant, four groups of rats were used (n = 6). The control group received 10 mL of water, the second and third groups received two doses of the plant (100 and 150 mg/kg bw), and the last group received furosemide (10 mg/kg bw), the experiment sustained for seven days. Urine flow and electrolytes levels were studied. The single dose of C. nardus extract significantly increased urine flow after oral administration. In addition, daily administration of both doses of C. nardus significantly elevated urine excretion, opposite to the first group. C. nardus enhanced the urine elimination of sodium and potassium. Importantly, both doses have no effect on serum potassium level. Creatinine clearance was significantly elevated in a dose-dependent manner. This information will be considered as a keystone for further studies forward in applying new process to isolate active compounds of C. nardus responsible for its biological properties.","PeriodicalId":52659,"journal":{"name":"Traditional and Integrative Medicine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41776812","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. Falana, Quadri Olaide Nurudeen, S. S. Salimon, I. Abubakar
The abundance of plants with medicinal values has been of great impact on the skincare industry in Nigeria. However, proper documentation of plants with skincare values has not been made. Hence, this study was aimed at surveying the traditional medicinal values of some commonly used plants for the management of skin conditions by herbal practitioners in Ilorin metropolis. Ethnobotanical and demographic information of willing respondents were obtained on the most commonly used medicinal plants via semi-structured questionnaires and oral interviews. The names of the plants were further confirmed in the world flora online (www.worldfloraonline.org). A total of 57 plants species representing 30 families, were reported by 62 respondents including males (40%) and females (60%) designated as herbs sellers (32%), traditional medicine practitioners (16%), farmers (8%), and housewives (11 %). Their knowledge sources include inheritance (40%), training (24 %), and a combination of inheritance and training (36%). Euphorbiaceae was the most cited (11 %) plant family, the leaves were the most cited (48%) plant part used, crush to extract juice was the most widely used (51%) method of preparation, and topical application on the affected spot was the most reported (43%) method of administration. The plants mentioned in this survey were reported to have applications against psoriasis, eczema, boils, acne, measles, dandruff, rashes, and wounds. General skin conditions represented the most commonly mentioned (14%) skin condition; while mastitis was the least mentioned (1%) condition. Also, the highest (0.923) informant consensus factor (ICF) was mentioned for insect bites; while the least (0.263) ICF was mentioned for general skin conditions. This study documented some of the medicinal plants that have been used to treat various skin-related conditions most of which have been mentioned in available scientific pieces of literature.
{"title":"Ethnopharmacological Survey of Medicinal Plants Used in the Management of Skin-Related Conditions in Ilorin, North-Central, Nigeria","authors":"M. Falana, Quadri Olaide Nurudeen, S. S. Salimon, I. Abubakar","doi":"10.18502/tim.v8i1.12404","DOIUrl":"https://doi.org/10.18502/tim.v8i1.12404","url":null,"abstract":"The abundance of plants with medicinal values has been of great impact on the skincare industry in Nigeria. However, proper documentation of plants with skincare values has not been made. Hence, this study was aimed at surveying the traditional medicinal values of some commonly used plants for the management of skin conditions by herbal practitioners in Ilorin metropolis. Ethnobotanical and demographic information of willing respondents were obtained on the most commonly used medicinal plants via semi-structured questionnaires and oral interviews. The names of the plants were further confirmed in the world flora online (www.worldfloraonline.org). A total of 57 plants species representing 30 families, were reported by 62 respondents including males (40%) and females (60%) designated as herbs sellers (32%), traditional medicine practitioners (16%), farmers (8%), and housewives (11 %). Their knowledge sources include inheritance (40%), training (24 %), and a combination of inheritance and training (36%). Euphorbiaceae was the most cited (11 %) plant family, the leaves were the most cited (48%) plant part used, crush to extract juice was the most widely used (51%) method of preparation, and topical application on the affected spot was the most reported (43%) method of administration. The plants mentioned in this survey were reported to have applications against psoriasis, eczema, boils, acne, measles, dandruff, rashes, and wounds. General skin conditions represented the most commonly mentioned (14%) skin condition; while mastitis was the least mentioned (1%) condition. Also, the highest (0.923) informant consensus factor (ICF) was mentioned for insect bites; while the least (0.263) ICF was mentioned for general skin conditions. This study documented some of the medicinal plants that have been used to treat various skin-related conditions most of which have been mentioned in available scientific pieces of literature.","PeriodicalId":52659,"journal":{"name":"Traditional and Integrative Medicine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49322493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Lawsonia inermis L. (henna) leaves have good antimicrobial, anti-inflammatory and wound healing properties. It is used topically in the form of hamul in gynaecological infections in traditional medicine. However, due to the unpleasant dosage form, it has very low patient compliance. Hence, in this study hydroalcoholic extract-based vaginal suppository of henna leaves was formulated and evaluated for various parameters. Multiple batches of suppository were prepared using poly[1]ethylene glycol (PEG)-4000, PEG-400, Tween-80, Span-60, distilled water and henna hydroalcoholic extract. Based on the organoleptic character and optimization tests, the final batch was selected. The final batch was evaluated for various physicochemical parameters and antimicrobial activities. Batch containing extract 30%, PEG-4000 37.38%, PEG-400 19%, distilled water 4.55%, Tween-80 and Span 60 4.535% each, passed the disintegration time (11.45 min), mucoadhesiveness (90°) and melting point (37 °C) test and selected as an optimized batch. The mean weight of a suppository was 1.56±0.03 g. Secondary plant metabolites in henna leaves and suppository were comparable. Various molecules identified in leaves were also noted in the suppository on GC-MS. Heavy metals and microbial contamination were within the permissible limit. Zone of inhibition (at 50 µg/mL) and minimum inhibitory concentration for E. coli, S. aureus, S. pyogenes, P. aeruginosa and C. albicans were 20 mm, 18 mm, 20 mm, 16 mm, 19 mm and 20 µg/mL, 10 µg/mL, 25 µg/mL, 25 µg/mL, 45 µg/mL, respectively. This study indicated satisfactory physicochemical parameters and antimicrobial potential of the hydroalcoholic extract-based vaginal suppository of henna. Hence, it may be considered as a better alternative to its traditional dosage form.
{"title":"Development, Characterization, and In Vitro Antimicrobial Activity of Lawsonia inermis L. Leaves Hydroalcoholic Extract-Based Vaginal Suppositories","authors":"","doi":"10.18502/tim.v8i1.12399","DOIUrl":"https://doi.org/10.18502/tim.v8i1.12399","url":null,"abstract":"Lawsonia inermis L. (henna) leaves have good antimicrobial, anti-inflammatory and wound healing properties. It is used topically in the form of hamul in gynaecological infections in traditional medicine. However, due to the unpleasant dosage form, it has very low patient compliance. Hence, in this study hydroalcoholic extract-based vaginal suppository of henna leaves was formulated and evaluated for various parameters. Multiple batches of suppository were prepared using poly[1]ethylene glycol (PEG)-4000, PEG-400, Tween-80, Span-60, distilled water and henna hydroalcoholic extract. Based on the organoleptic character and optimization tests, the final batch was selected. The final batch was evaluated for various physicochemical parameters and antimicrobial activities. Batch containing extract 30%, PEG-4000 37.38%, PEG-400 19%, distilled water 4.55%, Tween-80 and Span 60 4.535% each, passed the disintegration time (11.45 min), mucoadhesiveness (90°) and melting point (37 °C) test and selected as an optimized batch. The mean weight of a suppository was 1.56±0.03 g. Secondary plant metabolites in henna leaves and suppository were comparable. Various molecules identified in leaves were also noted in the suppository on GC-MS. Heavy metals and microbial contamination were within the permissible limit. Zone of inhibition (at 50 µg/mL) and minimum inhibitory concentration for E. coli, S. aureus, S. pyogenes, P. aeruginosa and C. albicans were 20 mm, 18 mm, 20 mm, 16 mm, 19 mm and 20 µg/mL, 10 µg/mL, 25 µg/mL, 25 µg/mL, 45 µg/mL, respectively. This study indicated satisfactory physicochemical parameters and antimicrobial potential of the hydroalcoholic extract-based vaginal suppository of henna. Hence, it may be considered as a better alternative to its traditional dosage form.","PeriodicalId":52659,"journal":{"name":"Traditional and Integrative Medicine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41888710","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Tai Chi (TC) has been often provided to older adults by rehabilitation professionals for medical dysfunction and anti-aging healthcare. In last decade, there has been an increase in the number of studies examining the effects of TC on brain as assessed by neuroimaging including near infrared spectroscopy (fNIRS), and structure and functional magnetic resonating imaging (sMRI & fMRI). Thus, the primary purpose of this literature review is to evaluate how TC practice may affect the brain in the elderly as assessed by neuroimaging techniques, and followed by corresponding neurobehavioral changes as the secondary purpose. A comprehensive literature search was conducted using a variety of keywords with different search engines to search from the last ten years until January 15, 2022. Studies were included if they investigated topographic brain responses after TC practice in the elderly population. A total of 12 original studies with 15 articles met the criteria and were included for the review process. The results showed increased volume of cortical grey matter, improved neural activity and homogeneity, and increased neural connectivity in different brain regions, including the frontal, temporal, and occipital lobes, cerebellum, and thalamus. Intriguingly, the longer one practices TC, the more his/her brain regions may be altered. Such neural findings after TC practice are often associated with neurobehavioral improvements in attention, cognitive execution, memory, emotion, and risk-taking behaviors. TC is a promising exercise that is able to improve structural capability and neurofunctional activity in the brain in the elderly. These improvements appear to be associated with the time-length of TC practice.
{"title":"Brain Structural Response and Neurobehavioral Changes in the Elderly after Tai Chi Practice - A Literature Review","authors":"Howe Liu, Yasser Salem, Eric Arguello, Hao Liu","doi":"10.18502/tim.v8i1.12406","DOIUrl":"https://doi.org/10.18502/tim.v8i1.12406","url":null,"abstract":"Tai Chi (TC) has been often provided to older adults by rehabilitation professionals for medical dysfunction and anti-aging healthcare. In last decade, there has been an increase in the number of studies examining the effects of TC on brain as assessed by neuroimaging including near infrared spectroscopy (fNIRS), and structure and functional magnetic resonating imaging (sMRI & fMRI). Thus, the primary purpose of this literature review is to evaluate how TC practice may affect the brain in the elderly as assessed by neuroimaging techniques, and followed by corresponding neurobehavioral changes as the secondary purpose. A comprehensive literature search was conducted using a variety of keywords with different search engines to search from the last ten years until January 15, 2022. Studies were included if they investigated topographic brain responses after TC practice in the elderly population. A total of 12 original studies with 15 articles met the criteria and were included for the review process. The results showed increased volume of cortical grey matter, improved neural activity and homogeneity, and increased neural connectivity in different brain regions, including the frontal, temporal, and occipital lobes, cerebellum, and thalamus. Intriguingly, the longer one practices TC, the more his/her brain regions may be altered. Such neural findings after TC practice are often associated with neurobehavioral improvements in attention, cognitive execution, memory, emotion, and risk-taking behaviors. TC is a promising exercise that is able to improve structural capability and neurofunctional activity in the brain in the elderly. These improvements appear to be associated with the time-length of TC practice.","PeriodicalId":52659,"journal":{"name":"Traditional and Integrative Medicine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47633188","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Lavandula angustifolia Mill. (lavender) is known for its antibacterial, muscle relaxant, antispasmodic, sedative, and anesthetic effects, and is also proposed to be used as an analgesic agent. Despite several studies on the analgesic activity of lavender, this is the first experiment in patients with orthodontic pain. This "2-arm parallel" study aims to evaluate the effect of lavender oil inhalation on reducing pain after elastomeric separator placement as a part of orthodontic treatment. Patients who needed elastic separator placement in mesial and distal of first permanent molars of all quadrants prior to their first-ever fixed orthodontic treatment, with the age range of 20 to 24, were randomly assigned to one of the two study groups: lavender oil and sesame oil. Participants had to breathe in their medication for 2 minutes just before separator insertion, as well as 4, 8, 12, 24, 36, and 48 h afterward. A visual analog scale (VAS) was used to measure the level of pain during three oral situations, including rest, fitting posterior teeth, and chewing at the following periods: just before separator placement (T0), immediately after insertion (T1), 3 h post-insertion (T2), 12 h post-(T3), 24 insertion h post-insertion (T4), and 48 h after separator placement (T5). The current study indicated the effectiveness of lavender oil inhalation in reducing pain perception while chewing 48 h after elastic separator placement. The pain level in lavender inhalation was lower from 12 h to 48 h after separator insertion, although not considerable, indicating the probability of its effectiveness on delayed responses to orthodontic pain.
{"title":"The Effect of Lavender Inhalation on the Pain Perception of Orthodontic Separator Placement: An Open-Label Randomized Controlled Trial","authors":"Maryam Tazarvifard Shirazi, Maryam Karandish","doi":"10.18502/tim.v7i4.11485","DOIUrl":"https://doi.org/10.18502/tim.v7i4.11485","url":null,"abstract":"Lavandula angustifolia Mill. (lavender) is known for its antibacterial, muscle relaxant, antispasmodic, sedative, and anesthetic effects, and is also proposed to be used as an analgesic agent. Despite several studies on the analgesic activity of lavender, this is the first experiment in patients with orthodontic pain. This \"2-arm parallel\" study aims to evaluate the effect of lavender oil inhalation on reducing pain after elastomeric separator placement as a part of orthodontic treatment. Patients who needed elastic separator placement in mesial and distal of first permanent molars of all quadrants prior to their first-ever fixed orthodontic treatment, with the age range of 20 to 24, were randomly assigned to one of the two study groups: lavender oil and sesame oil. Participants had to breathe in their medication for 2 minutes just before separator insertion, as well as 4, 8, 12, 24, 36, and 48 h afterward. A visual analog scale (VAS) was used to measure the level of pain during three oral situations, including rest, fitting posterior teeth, and chewing at the following periods: just before separator placement (T0), immediately after insertion (T1), 3 h post-insertion (T2), 12 h post-(T3), 24 insertion h post-insertion (T4), and 48 h after separator placement (T5). The current study indicated the effectiveness of lavender oil inhalation in reducing pain perception while chewing 48 h after elastic separator placement. The pain level in lavender inhalation was lower from 12 h to 48 h after separator insertion, although not considerable, indicating the probability of its effectiveness on delayed responses to orthodontic pain.","PeriodicalId":52659,"journal":{"name":"Traditional and Integrative Medicine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45557323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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