C. Possas, A. Antunes, A. Oliveira, S. Schumacher, E. Marques, A. Homma
applicants of of different different Methods: From a patent landscape approach, we defined methodological strategies for a hybrid search in two different databases (Derwent Innovation Index and Cortellis Drug Discovery Intelligence) that allowed us to identify the stages of technological development of the vaccines to prevent/treat these four arboviral diseases, making it possible to identify the successful ones that go to clinical trials and the partnerships among private and public institutions, which promote continuity of the development/production process. Results: Our results confirm these gaps for Dengue, Chikungunya, Zika and Yellow Fever vaccines, with only 13% of these vaccines still under active development and prospect to reach the final stages of development. They also indicate that, in spite of this constraint, innovative platforms such as RNA-based vaccines are increasingly being used to prevent/ treat these diseases. Conclusion: We propose urgently strengthening funding and incentive mechanisms in a Global Strategic Plan supported by new business models and community participation to accelerate vaccine development for these four neglected arboviral diseases, a dramatic and concerning global issue in post-COVID-19 era.
{"title":"Vaccine Innovation for Dengue, Chikungunya, Zika and Yellow Fever: Accelerating Global Development Agenda and Partnerships in Post-COVID Era","authors":"C. Possas, A. Antunes, A. Oliveira, S. Schumacher, E. Marques, A. Homma","doi":"10.52547/vacres.9.1.1","DOIUrl":"https://doi.org/10.52547/vacres.9.1.1","url":null,"abstract":"applicants of of different different Methods: From a patent landscape approach, we defined methodological strategies for a hybrid search in two different databases (Derwent Innovation Index and Cortellis Drug Discovery Intelligence) that allowed us to identify the stages of technological development of the vaccines to prevent/treat these four arboviral diseases, making it possible to identify the successful ones that go to clinical trials and the partnerships among private and public institutions, which promote continuity of the development/production process. Results: Our results confirm these gaps for Dengue, Chikungunya, Zika and Yellow Fever vaccines, with only 13% of these vaccines still under active development and prospect to reach the final stages of development. They also indicate that, in spite of this constraint, innovative platforms such as RNA-based vaccines are increasingly being used to prevent/ treat these diseases. Conclusion: We propose urgently strengthening funding and incentive mechanisms in a Global Strategic Plan supported by new business models and community participation to accelerate vaccine development for these four neglected arboviral diseases, a dramatic and concerning global issue in post-COVID-19 era.","PeriodicalId":52727,"journal":{"name":"Vaccine Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42435027","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Toll -like receptors (TLRs) are a class of pattern recognition receptors (PRRs) that detect pathogen associated molecular patterns and activate innate and adaptive immune system. Coronaviruses can be detected via TLRs through their biological materials such as ribonucleic acids, glycoproteins and CpG motifs. During COVID -19 pandemic, different strategies have been used for combating SARS -CoV -2 to initiate a proper and balanced immune response through TLRs or other PRRS. Understanding the trigerred TLR signaling pathways during coronavirus infections would assist to understand the control and defense mechanisms against these viral diseases. In this review, we summarize different studies on the use and function of of TLRs and their signaling pathways as vaccines/adjuvants or therapeutic agents against coronavirus infections. Since the pandemic is ongoing and there still many unknowns with respect to COVID -19 immunology, we highlight the role of TLRs and their agonists/antagonists in previous coronavirus infections, and show their potential role in the current SARS -CoV -2 immunopathology.
{"title":"Roles and Functions of Toll-Like Receptors in Coronavirus Infections: Forthcoming Vaccine and Therapeutic Strategies for Confronting COVID-19","authors":"A. Zahmatkesh, M. Bagheri","doi":"10.52547/vacres.8.2.17","DOIUrl":"https://doi.org/10.52547/vacres.8.2.17","url":null,"abstract":"Toll -like receptors (TLRs) are a class of pattern recognition receptors (PRRs) that detect pathogen associated molecular patterns and activate innate and adaptive immune system. Coronaviruses can be detected via TLRs through their biological materials such as ribonucleic acids, glycoproteins and CpG motifs. During COVID -19 pandemic, different strategies have been used for combating SARS -CoV -2 to initiate a proper and balanced immune response through TLRs or other PRRS. Understanding the trigerred TLR signaling pathways during coronavirus infections would assist to understand the control and defense mechanisms against these viral diseases. In this review, we summarize different studies on the use and function of of TLRs and their signaling pathways as vaccines/adjuvants or therapeutic agents against coronavirus infections. Since the pandemic is ongoing and there still many unknowns with respect to COVID -19 immunology, we highlight the role of TLRs and their agonists/antagonists in previous coronavirus infections, and show their potential role in the current SARS -CoV -2 immunopathology.","PeriodicalId":52727,"journal":{"name":"Vaccine Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47794542","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Arezoo Chouhdari, Yasamin Khosravani-Nezhad, Termeh Tarjoman, M. Zangeneh
Introduction: This study aimed to evaluate the baseline characteristics of patients infected with SARS-CoV-2, after receiving first or second doses of COVID-19 vaccine.
本研究旨在评估感染SARS-CoV-2的患者在接受第一剂或第二剂COVID-19疫苗后的基线特征。
{"title":"Basic characteristics of patients with COVID-19 after SARS‐CoV‐2 vaccine: One cross-sectional study in Iran","authors":"Arezoo Chouhdari, Yasamin Khosravani-Nezhad, Termeh Tarjoman, M. Zangeneh","doi":"10.52547/vacres.8.2.88","DOIUrl":"https://doi.org/10.52547/vacres.8.2.88","url":null,"abstract":"Introduction: This study aimed to evaluate the baseline characteristics of patients infected with SARS-CoV-2, after receiving first or second doses of COVID-19 vaccine.","PeriodicalId":52727,"journal":{"name":"Vaccine Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45090018","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Healthcare workers (HCW) are at an increased risk of acquiring vaccine preventable diseases (VPD) due to their higher patient exposure at the workplace. In this context, they form an important target population for vaccination. The authors of this article wanted to explore into the history of vaccination, the risk profile of the health care workers and the current vaccines recommended for the health care workers. Looking forward, vaccine uptake among the healthcare workers can be improved by measures such as conducting periodic annual health check ups and establishing written hospital vaccination policies.
{"title":"The Healthcare Workers’ Vaccination – current Policy and Recommendations","authors":"Merlyn Joseph, B. Joseph","doi":"10.52547/vacres.8.2.62","DOIUrl":"https://doi.org/10.52547/vacres.8.2.62","url":null,"abstract":"Healthcare workers (HCW) are at an increased risk of acquiring vaccine preventable diseases (VPD) due to their higher patient exposure at the workplace. In this context, they form an important target population for vaccination. The authors of this article wanted to explore into the history of vaccination, the risk profile of the health care workers and the current vaccines recommended for the health care workers. Looking forward, vaccine uptake among the healthcare workers can be improved by measures such as conducting periodic annual health check ups and establishing written hospital vaccination policies.","PeriodicalId":52727,"journal":{"name":"Vaccine Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42448894","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
R. Akele, Seyi S. Enitan, E. Adejumo, E. Ezigbo, A. Durosinmi, G. Itodo, Adedeji Abdulsalam, M. Dada, O. Edafetanure-Ibeh, Oyekan Oyedoyin, Polit U. Yelpoji, Abah Idoko, Ogunwola Opeyemi, Ogbuji Nmesomachi, Edwin N. Okafor, A. Oyekale
Introduction: Vaccine hesitancy is a global phenomenon and vaccination efforts against the Coronavirus Disease 2019 (COVID-19) pandemic may be hampered by it. This study assessed the acceptance rate of COVID-19 vaccination at different hypothetical efficacy and safety levels in Nigeria.
{"title":"Acceptance of COVID-19 Vaccination at Different Hypothetical Efficacy and Safety Levels in Nigeria: A Cross-Sectional Web-based Survey","authors":"R. Akele, Seyi S. Enitan, E. Adejumo, E. Ezigbo, A. Durosinmi, G. Itodo, Adedeji Abdulsalam, M. Dada, O. Edafetanure-Ibeh, Oyekan Oyedoyin, Polit U. Yelpoji, Abah Idoko, Ogunwola Opeyemi, Ogbuji Nmesomachi, Edwin N. Okafor, A. Oyekale","doi":"10.52547/vacres.8.2.93","DOIUrl":"https://doi.org/10.52547/vacres.8.2.93","url":null,"abstract":"Introduction: Vaccine hesitancy is a global phenomenon and vaccination efforts against the Coronavirus Disease 2019 (COVID-19) pandemic may be hampered by it. This study assessed the acceptance rate of COVID-19 vaccination at different hypothetical efficacy and safety levels in Nigeria.","PeriodicalId":52727,"journal":{"name":"Vaccine Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46099672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Seyedeh Marzieh Moosavi, A. Akhavan Sepahi, Seyed Fazlollah Mousavi, F. Vaziri, S. Siadat
extracellular (EVs) a novel communication between microbiota the are capable of imposing positive effects on the host. Recently, EV-based treatments have been evaluated in different studies, and using EVs derived from microbiota has been recommended in recent studies as post-vaccination adjuvants. Accordingly, in the present study, the effects of various EV concentrations on the mRNA expression of peroxisome proliferator-activated receptor γ ( PPARγ ) and fasting-induced adipose factor (FIAF) genes were evaluated and optimized in the human epithelial colorectal adenocarcinoma (Caco-2) cell line. Methods: The effects of the extracted EVs from F. prausnitzii on the PPARγ and FIAF gene expression were investigated in the Caco-2 cell line via cell culture and quantitative real-time PCR. The obtained outcomes were then compared with those of our previous study (concentrations of 50 and 100 µg/ml). Results: It was shown that F. prausnitzii EVs (150 µg/ml) significantly increased PPARγ and FIAF gene expression in the Caco-2 cell line, relative to previous studies conducted by our team. Conclusion: Considering the positive impact of F. Prausnitzii EVs on the studied genes’ expression in the present study, the EVs of the bacterium will be proposed as new post-vaccination adjuvants in people suffering from intestinal barrier disorders such as inflammatory bowel disease patients. However, more studies should be performed in this respect.
{"title":"The Optimization of Faecalibacterium prausnitzii Extracellular Vesicle Concentrations on PPARγ and FIAF Expression in the Caco-2 Cell Culture Model","authors":"Seyedeh Marzieh Moosavi, A. Akhavan Sepahi, Seyed Fazlollah Mousavi, F. Vaziri, S. Siadat","doi":"10.52547/vacres.8.2.39","DOIUrl":"https://doi.org/10.52547/vacres.8.2.39","url":null,"abstract":"extracellular (EVs) a novel communication between microbiota the are capable of imposing positive effects on the host. Recently, EV-based treatments have been evaluated in different studies, and using EVs derived from microbiota has been recommended in recent studies as post-vaccination adjuvants. Accordingly, in the present study, the effects of various EV concentrations on the mRNA expression of peroxisome proliferator-activated receptor γ ( PPARγ ) and fasting-induced adipose factor (FIAF) genes were evaluated and optimized in the human epithelial colorectal adenocarcinoma (Caco-2) cell line. Methods: The effects of the extracted EVs from F. prausnitzii on the PPARγ and FIAF gene expression were investigated in the Caco-2 cell line via cell culture and quantitative real-time PCR. The obtained outcomes were then compared with those of our previous study (concentrations of 50 and 100 µg/ml). Results: It was shown that F. prausnitzii EVs (150 µg/ml) significantly increased PPARγ and FIAF gene expression in the Caco-2 cell line, relative to previous studies conducted by our team. Conclusion: Considering the positive impact of F. Prausnitzii EVs on the studied genes’ expression in the present study, the EVs of the bacterium will be proposed as new post-vaccination adjuvants in people suffering from intestinal barrier disorders such as inflammatory bowel disease patients. However, more studies should be performed in this respect.","PeriodicalId":52727,"journal":{"name":"Vaccine Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43896789","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Shima Poorghobadi, K. Baesi, S. M. Sadat, A. Abdoli, S. Irani
Introduction: The aim of this study was to evaluate the effects of an adenoviral vector vaccine candidate containing HSV-TK gene on tumor reduction and autophagy mechanism in animal model. Methods: Myeloma tumor was created in mouse models using myeloma SP2/0 cell line. Three groups of negative control, positive control and target group of BALB/c mice were formed. Candidates for the Ad-HSV-tk /GCV vaccine at high titer (10 8 ) were then injected three times every 72 hours at target mice and metformin was injected into the control group for 12 consecutive days. Tumor size was measured in all 15 mice studied every three days, and finally, three days after the last dose of the vaccine, the tumors were removed for Western blotting and LC3B expression. Results: Examination of tumor size showed that injection of the vaccine and autophagy-inducing drug reduced tumor size compared to the negative control group. Western blotting indicated that LC3B expression was significantly higher in the target and positive control groups than in the negative control group. (Mean Diff: -0.4921; P value < 0.05; q: 7.911). Conclusion: The results suggest that Ad-HSV-tk/GCV vaccine candidate was able to induce autophagy and reduce the growth of tumor cells in the animal model studied due to the ability of adenovirus to induce the immune system response, the anti-myeloma nature of adenovirus and the function of HSV-tk suicide gene. suicide gene in adenovirus vector to make a viral vaccine, we investigated the effect of this vaccine on tumor cell growth and autophagic cell death.
{"title":"Evaluation of the Effect of HSV-tk/GCV Adenoviral Vector Vaccine Candidate in Inhibiting the Growth of Myeloma Tumors by Inducing Autophagy in BALB/c Mice","authors":"Shima Poorghobadi, K. Baesi, S. M. Sadat, A. Abdoli, S. Irani","doi":"10.52547/vacres.8.2.44","DOIUrl":"https://doi.org/10.52547/vacres.8.2.44","url":null,"abstract":"Introduction: The aim of this study was to evaluate the effects of an adenoviral vector vaccine candidate containing HSV-TK gene on tumor reduction and autophagy mechanism in animal model. Methods: Myeloma tumor was created in mouse models using myeloma SP2/0 cell line. Three groups of negative control, positive control and target group of BALB/c mice were formed. Candidates for the Ad-HSV-tk /GCV vaccine at high titer (10 8 ) were then injected three times every 72 hours at target mice and metformin was injected into the control group for 12 consecutive days. Tumor size was measured in all 15 mice studied every three days, and finally, three days after the last dose of the vaccine, the tumors were removed for Western blotting and LC3B expression. Results: Examination of tumor size showed that injection of the vaccine and autophagy-inducing drug reduced tumor size compared to the negative control group. Western blotting indicated that LC3B expression was significantly higher in the target and positive control groups than in the negative control group. (Mean Diff: -0.4921; P value < 0.05; q: 7.911). Conclusion: The results suggest that Ad-HSV-tk/GCV vaccine candidate was able to induce autophagy and reduce the growth of tumor cells in the animal model studied due to the ability of adenovirus to induce the immune system response, the anti-myeloma nature of adenovirus and the function of HSV-tk suicide gene. suicide gene in adenovirus vector to make a viral vaccine, we investigated the effect of this vaccine on tumor cell growth and autophagic cell death.","PeriodicalId":52727,"journal":{"name":"Vaccine Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46378106","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
is among the most successful organ transplantations in humans due to its immune privilege. This owes to lack of blood and lymph vessels and the absence of major histocompatibility complex antigen presenting cells (MHC-II APCs) in the cornea. However, vaccination may trigger MHC-II response as well as antigenic cross reactivity, resulting in allograft rejection. This has been reported earlier in sporadic cases after influenza and yellow fever vaccines. With the rampant vaccination and booster doses against COVID-19, similar episodes of post-vaccination graft rejection in penetrating and lamellar keratoplasties have been reported. We had reported a case of corneal graft rejection post covid vector vaccine which recovered with steroid medications. Allograft rejection with various subtypes of vaccination opens the door to comprehend immune privilege mechanisms and prophylaxis against organ rejection. Clinicians and patients are advised to be alert to this possibility, for prompt recognition as well as treatment of post-vaccination corneal graft rejection.
{"title":"Commentary on Corneal Graft Rejection after COVID-19 Vaccination: Our Experience and Concerns","authors":"R. Natarajan, Swetha Ravichandran","doi":"10.52547/vacres.8.2.26","DOIUrl":"https://doi.org/10.52547/vacres.8.2.26","url":null,"abstract":"is among the most successful organ transplantations in humans due to its immune privilege. This owes to lack of blood and lymph vessels and the absence of major histocompatibility complex antigen presenting cells (MHC-II APCs) in the cornea. However, vaccination may trigger MHC-II response as well as antigenic cross reactivity, resulting in allograft rejection. This has been reported earlier in sporadic cases after influenza and yellow fever vaccines. With the rampant vaccination and booster doses against COVID-19, similar episodes of post-vaccination graft rejection in penetrating and lamellar keratoplasties have been reported. We had reported a case of corneal graft rejection post covid vector vaccine which recovered with steroid medications. Allograft rejection with various subtypes of vaccination opens the door to comprehend immune privilege mechanisms and prophylaxis against organ rejection. Clinicians and patients are advised to be alert to this possibility, for prompt recognition as well as treatment of post-vaccination corneal graft rejection.","PeriodicalId":52727,"journal":{"name":"Vaccine Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42144305","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
CoronaVirus Disease 2019 (COVID-19) is a viral infection caused by the Severe Acute Respiratory Syndrome CoronaVirus 2 (SARS-CoV-2), which is globally influential and has killed more than 6 million patients until today. Hyper-secretion of pro-inflammatory cytokines triggered by the viral infection that cannot be eliminated by the immune system and an ongoing hyper-inflammatory state primarily in the lung seem to be the major causes of death. The mechanisms proposed to explain the pathogenesis of the cytokine storm associated with COVID-19 included poor viral clearance and persistent robust cytokine response despite inadequate antiviral immunity. The diagnosis can be made easily by clinical features, imaging techniques, and nasopharyngeal PCR. The diagnosis of this hyper-inflammatory state in a patient with COVID-19 can be made with rapid deterioration in clinical features, and laboratory findings including abnormally high serum CRP, ferritin and D-dimer levels, and rapidly progressive pulmonary radiological findings. In addition to the anti-viral and supportive treatments, corticosteroids, IL-1, or IL-6 receptor blockers are frequently used to suppress the increased cytokine response.
{"title":"An Update on Pathogenesis, Diagnosis and Treatment of COVID-19-Related Cytokine Storm","authors":"M. Soy, P. Atagunduz, G. Keser","doi":"10.52547/vacres.8.2.48","DOIUrl":"https://doi.org/10.52547/vacres.8.2.48","url":null,"abstract":"CoronaVirus Disease 2019 (COVID-19) is a viral infection caused by the Severe Acute Respiratory Syndrome CoronaVirus 2 (SARS-CoV-2), which is globally influential and has killed more than 6 million patients until today. Hyper-secretion of pro-inflammatory cytokines triggered by the viral infection that cannot be eliminated by the immune system and an ongoing hyper-inflammatory state primarily in the lung seem to be the major causes of death. The mechanisms proposed to explain the pathogenesis of the cytokine storm associated with COVID-19 included poor viral clearance and persistent robust cytokine response despite inadequate antiviral immunity. The diagnosis can be made easily by clinical features, imaging techniques, and nasopharyngeal PCR. The diagnosis of this hyper-inflammatory state in a patient with COVID-19 can be made with rapid deterioration in clinical features, and laboratory findings including abnormally high serum CRP, ferritin and D-dimer levels, and rapidly progressive pulmonary radiological findings. In addition to the anti-viral and supportive treatments, corticosteroids, IL-1, or IL-6 receptor blockers are frequently used to suppress the increased cytokine response.","PeriodicalId":52727,"journal":{"name":"Vaccine Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45448784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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